TWAS hub - PPP4R1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.2082	0.0485	3.7e-06	0.137	NA	0.120	NA	0.145	7.7e-11	NA	1.2e-09	NA	1.8e-11
2	GTEx	Cells Transformed fibroblasts	0.1660	0.0530	1.1e-03	0.000	NA	0.008	NA	-0.001	3.1e-01	NA	7.6e-02	NA	4.0e-01
3	GTEx	Nerve Tibial	0.1669	0.0451	1.0e-05	0.105	NA	0.132	NA	0.126	7.8e-08	NA	1.3e-09	NA	3.4e-09
4	NTR	Blood	0.0370	0.0112	1.3e-04	0.010	0.013	0.022	0.020	0.023	3.3e-04	4.0e-05	1.1e-07	3.4e-07	4.7e-08
5	ROSMAP	Brain Pre-frontal Cortex	0.0921	0.0317	1.9e-03	0.029	0.035	0.027	0.039	0.029	1.2e-04	2.1e-05	1.6e-04	7.2e-06	1.2e-04
6	YFS	Blood	0.1492	0.0213	0.0e+00	0.036	0.106	0.119	0.118	0.113	6.1e-12	9.3e-33	6.7e-37	2.2e-36	6.2e-35
7	TCGA	Breast Invasive Carcinoma	0.0249	0.0118	2.1e-03	0.015	0.007	0.003	NA	0.008	3.7e-04	1.1e-02	7.5e-02	NA	8.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	7.0	2.2	2.6	2.2	1.9	1.1	0.1	2.1
Mouth/teeth dental problems: Dentures	2.8	4.8	12.6	3.6	2.4	2.2	0.2	0.3	-0.3	3.2
Hand grip strength (right)	2.5	6.9	15.5	2.0	-1.2	3.9	-1.5	3.7	-3.2	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.4	3.1	11.1	-0.3	0.5	-1.3	2.4	-1.6	3.3	0.7
Hair/balding pattern: Pattern 2	2.3	2.9	7.7	-2.8	-0.4	-2.5	-0.5	0.8	0.3	-2.3
Mouth/teeth dental problems	2.3	3.6	11.7	-2.6	-2.1	-1.2	-0.1	0.7	0.7	-3.4
Mood swings	2.3	4.1	17.7	-1.9	-0.8	-2.4	-1.0	-4.2	-0.4	0.7
Emphysema/chronic bronchitis	2.2	2.4	10.6	1.1	3.3	0.1	-0.8	-0.2	-0.9	2.0
Medication: Omeprazole	2.2	2.6	5.5	2.0	2.3	1.2	1.5	1.1	0.4	1.9
Ever had bowel cancer screening	2.2	2.6	6.5	0.4	2.4	-0.3	2.5	-0.4	2.3	0.2
Coronary Artery Disease (CAD)	2.1	2.5	9.1	1.9	1.6	0.7	-0.3	-1.3	-0.3	3.0
Medication: Co-codamol	2.1	2.4	5.9	2.4	2.1	1.7	0.7	0.1	0.0	1.7
Illnesses of father: Heart disease	2.1	2.9	7.2	2.0	-0.2	2.7	-0.6	0.4	-2.5	1.4
Osteoarthritis (self-reported)	2.1	2.7	6.8	1.4	0.8	2.1	2.1	2.6	0.7	-0.4
Supplements: Calcium	2.1	2.3	5.1	2.0	2.2	1.6	0.9	1.3	1.1	0.8
Pack years of smoking	2.1	3.1	7.1	2.3	0.9	1.5	-1.6	0.7	-2.7	1.8
Average weekly spirits intake	2.0	2.5	3.8	2.0	1.7	0.5	-1.9	-0.6	-1.9	1.6
Hearing difficulty/problems with background noise	2.0	3.2	8.7	2.0	3.0	2.4	1.2	1.2	0.8	0.4
Wheeze or whistling in the chest in last year	2.0	3.6	8.0	2.8	2.2	1.9	-0.2	-0.6	-0.6	2.8
Pain type(s) experienced in last month: Hip pain	2.0	2.6	5.0	2.2	1.4	0.9	1.7	-0.9	1.2	2.2
Schizophrenia (2014)	1.9	4.1	6.7	-2.4	-1.8	-2.6	0.8	-1.8	1.6	-2.5
Hand grip strength (left)	1.9	5.0	9.2	1.7	-1.6	3.0	-1.5	2.9	-2.9	-1.2
Hearing difficulty/problems: Yes	1.9	2.9	6.1	2.1	2.5	2.5	0.6	1.8	-0.0	0.3
Supplements: Zinc	1.9	2.0	4.5	2.1	2.1	2.0	0.3	1.0	-0.3	0.1
Severe depression (siblings)	1.9	2.1	8.3	-0.3	1.5	0.3	2.9	-1.3	1.6	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	4.2	2.0	-0.5	1.7	-0.7	1.9	-1.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.9	3.9	10.4	1.3	-2.3	1.5	-2.6	0.6	-3.2	0.8
Eye problems/disorders: Cataract	1.9	2.2	5.3	-0.5	-0.6	-0.4	2.2	-0.1	2.3	-2.1
Mouth/teeth dental problems: Mouth ulcers	1.9	3.0	5.7	1.8	1.9	1.6	2.4	1.3	1.3	1.7
Pack years adult smoking proportion	1.8	2.7	8.2	1.8	0.4	1.3	-1.5	0.6	-2.9	1.7
Qualifications: None of the above	1.8	3.9	10.1	1.5	3.2	-1.4	-0.6	-1.8	0.7	3.0
Intelligence (Savage-Jansen 2018)	1.7	5.2	15.6	-1.1	-2.9	1.0	-0.6	3.1	-0.5	-3.9
Crohns Disease (2012)	1.7	2.7	4.6	1.3	1.6	1.1	-2.1	-0.8	-2.1	1.9
Number of live births	1.7	2.4	4.3	2.0	1.4	0.7	-1.9	-0.5	-2.1	1.5
Alcohol drinker status: Previous	1.7	2.0	4.1	1.7	1.9	0.6	-0.3	0.8	-1.4	2.0
HbA1C	1.6	1.8	6.1	0.7	-0.0	0.9	-2.5	0.3	-2.2	-0.4
Number of treatments/medications taken	1.6	2.8	9.3	1.3	3.1	1.2	2.0	1.2	1.1	0.7
Peak expiratory flow (PEF)	1.6	3.7	9.5	2.1	-0.1	3.1	-0.6	2.1	-2.6	0.8
Shortness of breath walking on level ground	1.6	1.9	3.5	1.4	0.5	1.8	-1.2	-0.0	-1.6	1.9
Medication: Allopurinol	1.6	2.1	7.3	-1.5	-0.8	0.1	1.4	1.3	1.0	-2.7
Miserableness	1.6	2.8	12.9	-0.6	1.2	-1.6	-1.0	-3.6	-0.6	1.0
Basal cell carcinoma (self-reported)	1.6	1.9	3.7	-1.8	-0.4	-0.7	1.9	-0.8	1.9	-1.2
Multivitamins +/- minerals	1.5	1.9	10.0	-1.6	-0.5	0.2	-0.4	0.8	0.1	-3.2
Asthma	1.5	3.0	6.1	2.3	0.9	1.8	-1.3	0.3	-2.5	2.0
Breastfed as a baby	1.5	1.8	5.9	0.8	1.0	1.7	-1.0	1.2	-2.4	0.0
Hearing aid user	1.5	1.7	4.0	-0.7	-0.1	-0.7	2.0	-1.7	2.0	0.2
Financial situation satisfaction	1.5	1.9	5.3	1.0	1.3	1.3	2.3	0.5	1.4	1.1
Schizophrenia (2018)	1.4	2.9	6.4	-2.0	-1.8	-2.0	0.6	-0.9	1.2	-2.5
Alzheimer’s Disease (including proxy)	1.4	2.1	4.0	1.2	2.0	1.7	1.8	1.4	0.1	1.1
LDL Cholesterol	1.4	2.2	4.8	-2.2	-1.8	-2.1	0.2	-1.1	0.1	-1.2
Respiratory disease	1.4	3.2	6.4	2.0	2.0	2.5	0.2	0.5	-2.1	1.8
Qualifications: CSEs or equivalent	1.4	1.9	7.7	-0.7	-2.8	-0.8	-1.7	-0.7	-0.5	1.0
High blood pressure	1.4	3.9	9.5	-1.8	0.4	-2.1	2.6	-1.9	3.1	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	7.5	-0.5	1.7	0.4	2.7	0.4	1.2	-0.4
Depression (self-reported)	1.4	1.6	3.0	-1.4	1.4	-0.4	1.7	1.3	1.1	-1.1
Medication: Lansoprazole	1.4	1.6	5.2	0.9	1.8	0.6	2.3	0.0	1.2	0.6
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.8	0.7	1.4	-0.6	0.1	-2.0	0.5	2.2
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	4.4	-0.4	-0.8	-0.9	-1.9	-1.6	-2.1	0.6
Suffer from ‘nerves’	1.4	2.2	6.4	-1.4	-0.2	-2.4	-1.2	-2.5	0.5	0.3
Chest pain or discomfort	1.4	2.1	5.3	1.6	2.3	0.9	0.6	-0.3	-0.4	2.3
Illnesses of siblings: Diabetes	1.4	1.8	4.7	2.2	0.9	2.1	-0.6	1.2	-0.9	-0.4
Asthma (self-reported)	1.4	2.8	5.7	2.1	0.9	1.9	-1.0	0.1	-2.4	2.0
Blood Platelet Count	1.3	15.3	50.9	1.2	2.4	3.3	7.1	1.3	4.8	3.7
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	3.9	-1.2	-0.1	-0.9	1.9	-0.3	2.0	-1.2
Relative age voice broke	1.3	1.9	4.1	2.0	0.5	2.0	-0.9	1.3	-1.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	5.5	-1.4	-0.6	-1.7	1.3	-2.3	1.2	0.3
Illnesses of siblings	1.3	1.9	5.0	-2.2	-1.6	-1.8	-0.1	-1.3	0.2	-0.8
Time employed in main current job	1.3	1.5	3.7	-1.9	0.2	-0.9	1.1	-0.1	1.2	-1.9
Prospective memory result	1.3	1.5	3.9	-1.2	0.3	-1.8	1.1	-1.0	2.0	0.1
Exposure to tobacco smoke at home	1.3	1.4	4.9	2.2	0.4	0.6	-0.0	-1.0	-0.8	1.8
Tense / ‘highly strung’	1.3	2.2	5.4	-2.0	0.6	-1.7	1.3	-2.3	1.0	-0.5
Long-standing illness, disability or infirmity	1.3	1.9	4.8	-0.2	2.2	-0.7	1.8	-1.1	1.9	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.5	0.6	0.2	-1.2	-1.4	-2.1	-0.2	1.5
Ever depressed for a whole week	1.3	1.6	2.9	-1.6	-1.7	-0.9	1.4	-1.7	0.7	0.1
Alzheimer’s Disease (in mother)	1.2	1.4	3.1	1.8	1.2	1.3	0.6	0.6	-0.9	1.4
Alcohol usually taken with meals	1.2	2.0	4.2	-1.0	-1.4	1.3	1.0	2.1	0.7	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.9	-1.5	-0.0	-0.8	-0.9	-1.3	-0.3	-2.0
Illnesses of mother	1.2	1.5	3.0	-1.6	-1.7	-1.5	-1.3	-0.6	0.0	-0.9
Qualifications: College or University degree	1.2	3.6	13.3	-2.5	-1.9	-0.3	1.2	0.4	0.6	-3.6
Medication: Ibuprofen	1.2	1.5	5.3	-0.8	1.1	0.1	2.3	1.3	1.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.4	0.9	0.0	0.7	-1.5	-1.3	-1.8	1.1
Medication: Lisinopril	1.2	1.6	2.7	-1.6	-0.8	-1.6	-0.5	-1.5	1.2	-1.1
Medication: Atorvastatin	1.2	1.4	3.9	-2.0	-0.2	-1.3	-0.7	-1.0	-0.6	-1.6
Crohns Disease (2017)	1.1	2.5	8.3	0.6	0.6	-0.4	-2.9	-1.6	-1.9	1.3
HDL Cholesterol	1.1	1.9	3.5	-1.7	-1.6	-0.9	1.6	-0.5	1.9	-0.7
Diabetes (father)	1.1	1.4	2.8	-1.5	-1.4	-0.7	0.2	1.4	0.0	-1.7
Townsend deprivation index at recruitment	1.1	1.5	4.2	2.1	0.6	1.3	-0.1	1.3	0.0	1.6
Neuroticism score	1.1	2.3	7.9	-1.9	-0.2	-1.8	-1.0	-2.8	0.1	-0.4
Hypertension (Self-reported)	1.1	3.1	7.9	-1.8	0.0	-1.9	2.2	-1.3	2.8	-0.4
Body Mass Index (BMI) (2010)	1.0	1.4	4.7	1.4	1.3	0.4	-0.3	0.7	-0.8	2.2
Mean Putamen Volume	1.0	1.2	4.8	0.2	-0.5	0.8	-2.2	0.5	-1.3	-0.7
Fasting Glucose	1.0	1.2	2.7	0.9	-0.6	0.6	-1.6	1.1	-1.6	0.5
Lupus	1.0	1.5	4.5	0.3	0.5	-1.5	-1.1	-2.1	-0.9	1.1
Neuroticism	1.0	2.3	8.6	-1.6	0.2	-2.0	-0.9	-2.9	-0.2	0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	3.1	0.9	1.3	-0.8	-0.8	-0.8	-0.3	1.8
Pain all over the body in last month	1.0	1.1	3.0	0.0	1.5	-0.6	0.8	1.7	0.4	-1.1
Alcohol intake versus 10 years previously	1.0	1.5	4.4	2.1	0.8	-0.7	-0.4	0.4	0.1	2.1
Happiness	1.0	1.2	2.8	1.2	0.7	1.5	-0.2	1.2	-1.7	0.7
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	5.6	-0.8	-2.4	-0.3	-0.7	-0.2	0.0	-2.1
Blood clot in the leg (DVT)	1.0	1.3	5.1	-1.0	-1.0	-1.2	0.4	-2.3	0.4	0.5
Medication for pain relief, constipation, heartburn	1.0	1.6	6.8	-0.6	-2.6	-0.6	-1.7	0.3	0.1	-1.0
Smoking status: Previous	1.0	1.5	4.2	0.5	1.6	-0.1	0.1	-2.1	-0.4	1.8
Handedness (chirality/laterality): Left-handed	1.0	1.3	3.1	-0.1	-1.8	0.8	-1.2	1.5	-1.1	-0.3
Qualifications: nursing, teaching	1.0	1.5	3.9	-1.7	-1.2	-0.8	0.8	-0.8	0.5	-2.0
Number of self-reported non-cancer illnesses	1.0	1.7	5.1	-0.3	2.3	0.0	1.9	-0.1	1.7	-0.4
Guilty feelings	1.0	1.4	2.6	-1.2	-1.6	-0.5	-1.6	-0.6	-1.5	-0.8
Illnesses of father: High blood pressure	1.0	1.2	3.2	0.3	0.4	-1.1	-1.0	-1.4	-1.1	1.8
Age started oral contraceptive pill	1.0	1.3	4.4	0.4	-0.3	-0.6	2.0	0.0	2.1	-0.1
Bipolar Disorder or Schizophrenia	0.9	2.3	6.1	-1.7	-1.0	-2.0	0.2	-1.4	0.5	-2.5
Irritable Bowel Disease (IBD)	0.9	2.2	6.1	1.4	0.4	0.2	-2.5	-1.2	-1.8	1.5
Triglycerides	0.9	1.4	2.7	1.5	1.7	1.0	-0.3	1.0	-1.0	1.4
Sensitivity / hurt feelings	0.9	1.6	5.2	-2.0	0.2	-1.2	0.0	-2.3	0.4	-0.7
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	3.1	0.6	0.8	-0.2	1.7	0.1	1.8	0.5
Qualifications: A levels/AS levels or equivalent	0.9	2.0	8.5	-1.3	-1.3	0.8	0.6	1.0	-0.1	-2.9
Pulse wave reflection index	0.9	1.1	2.0	-1.0	-1.4	0.4	-0.6	1.4	-0.9	-1.2
Medication: Amlodipine	0.9	1.2	2.9	-1.0	-1.6	-0.1	0.9	0.3	1.0	-1.7
Forced vital capacity (FVC), Best measure	0.9	3.2	10.0	-0.5	-2.4	1.6	-1.7	0.7	-3.2	-0.7
Age at first live birth	0.9	1.7	3.3	-1.1	-1.3	1.3	1.5	1.8	0.3	-1.2
Medication: Seretide 50 evohaler	0.9	1.0	3.9	0.7	-0.6	0.1	-1.0	-2.0	-0.6	1.0
Illnesses of father: None of the above (group 1)	0.9	1.1	2.6	-0.9	-0.5	-1.6	0.1	-1.2	1.4	-0.6
Wears glasses or contact lenses	0.9	1.0	5.2	1.1	2.3	0.6	-0.2	-0.4	0.2	0.2
Ever taken oral contraceptive pill	0.9	1.0	3.9	-1.6	-2.0	-0.7	0.0	-0.2	0.1	-0.2
Commuting to job workplace: Cycle	0.9	1.0	2.7	0.8	-0.1	0.4	1.6	1.0	1.6	0.4
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.9	1.2	-0.9	1.7	-2.0	1.7	-2.2	0.0
Depressed Affect (Nagel 2018)	0.8	1.6	6.2	-0.4	1.0	-1.5	-0.7	-2.5	-0.5	1.0
Neuroticism (Nagel 2018)	0.8	1.8	6.1	-0.2	1.0	-0.8	-1.2	-2.5	-1.1	1.3
Alzheimer’s Disease (in father)	0.8	0.9	2.3	-0.6	0.6	-0.0	1.5	0.9	1.0	-1.2
Verbal and Numeric Reasoning (VNR)	0.8	1.9	4.9	0.2	-2.2	1.2	-0.0	1.8	-0.3	-1.9
Cardiovascular Disease	0.8	2.5	8.1	-1.1	0.2	-1.7	2.1	-0.9	2.8	0.4
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.3	1.1	1.1	1.0	-0.5	0.8	-1.1	1.0
Vitamin and mineral supplements	0.8	1.1	5.7	0.9	0.9	-0.1	0.1	-0.5	-0.6	2.4
Trunk fat percentage	0.8	3.1	7.1	2.7	1.7	2.1	0.2	0.6	-0.7	2.5
Stomach or abdominal pain in last month	0.8	1.0	2.3	1.0	-0.1	1.0	-0.3	-1.5	-1.0	1.2
High blood pressure (mother)	0.8	1.2	4.3	1.6	0.4	0.8	0.8	0.1	0.2	2.1
Trunk fat mass	0.8	3.2	7.0	2.6	1.1	2.5	0.1	1.4	-1.0	2.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.4	-0.2	-0.3	-0.4	1.9	-0.7	1.4	0.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.6	0.8	1.9	1.0	0.1	-0.4	-0.9	1.1
Fluid intelligence score	0.8	1.6	4.4	0.2	-2.1	1.6	-0.6	0.2	-1.2	-1.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	6.6	0.5	-2.1	2.0	-1.3	1.4	-2.6	0.0
Lung cancer (father)	0.8	1.0	2.6	1.0	1.6	0.0	0.3	0.7	0.5	1.6
Headache pain in last month	0.8	1.4	2.6	1.2	1.2	1.6	1.6	-0.8	0.2	1.2
Gout (self-reported)	0.8	1.1	3.3	-0.7	0.8	0.3	1.8	0.4	0.7	-1.7
Knee pain experienced in last month	0.8	1.2	3.4	1.3	0.4	1.8	-1.1	0.4	-1.3	0.3
Loneliness, isolation	0.8	1.1	2.3	1.4	-0.0	1.5	-0.4	-0.2	-1.2	1.5
Average weekly beer plus cider intake	0.8	1.2	2.7	1.6	0.6	0.4	-1.1	0.0	-1.3	1.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	4.5	-0.6	-0.7	-0.9	0.3	-2.1	0.1	0.9
Schizophrenia vs Biploar Disorder	0.7	0.9	2.0	-1.2	-1.4	-1.1	0.1	0.4	0.2	-1.1
Ulcerative Colitis (UC)	0.7	1.2	3.4	1.8	0.4	0.6	-1.2	-0.5	-1.1	1.4
Major Depression (MDD)	0.7	0.9	2.0	-0.9	0.3	-0.3	1.4	-1.4	1.1	0.1
Neuroticism (2016)	0.7	1.0	4.8	-0.0	1.0	-0.5	-0.3	-2.2	0.2	0.9
Chronotype (morning person)	0.7	1.7	8.7	1.0	0.7	-0.4	-0.4	-1.1	-0.5	2.9
Relative age of first facial hair	0.7	1.4	2.7	1.6	1.1	0.6	-1.6	-0.2	-1.6	0.3
Taking other prescription medications	0.7	1.2	3.0	0.6	1.7	0.8	1.4	0.2	1.4	0.6
Serious illness, injury or assault to yourself	0.7	0.9	1.9	-0.8	-0.4	-0.9	0.9	-1.3	1.4	0.0
Number of incorrect matches in round	0.7	1.2	2.5	0.3	0.7	-0.8	1.5	-1.6	1.3	0.8
Forced vital capacity (FVC)	0.7	2.7	8.8	0.4	-2.0	1.7	-1.5	0.8	-3.0	0.0
Financial difficulties in last 2 years	0.7	0.9	2.3	0.9	1.5	0.2	0.6	-0.8	-0.3	1.5
Pulse rate	0.7	1.3	4.7	0.1	0.6	-0.8	1.6	-0.5	2.2	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	6.0	-0.4	-2.5	1.6	-0.9	1.0	-2.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.3	-0.7	0.4	-0.7	0.1	-2.1	-0.3	1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.8	2.6	0.8	0.7	0.8	-0.5	-0.0	-1.6	1.2
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.6	0.0	-1.1	0.2	-0.1	1.9	0.5	-1.1
Ever smoked	0.7	1.2	2.6	0.4	0.6	0.5	-1.1	-1.2	-1.6	1.6
Irritability	0.7	1.2	4.3	-1.4	-0.1	-1.1	-0.8	-2.1	-0.2	0.7
Heart disease (siblings)	0.7	0.9	2.6	0.7	1.0	1.6	0.6	1.1	0.5	-0.1
Reaction Time	0.6	1.1	1.8	1.4	1.3	1.1	-0.6	-0.0	-1.1	1.2
Age at First Birth	0.6	0.8	2.3	1.1	0.2	1.5	-0.4	0.0	-0.7	1.2
Rheumatoid Arthritis	0.6	0.9	1.4	-1.2	-0.7	-1.2	-0.1	-0.9	1.0	-1.0
Medication for hormone replacement therapy	0.6	0.6	1.7	1.3	0.4	0.8	0.1	-0.8	-0.3	1.1
Diabetes (mother)	0.6	0.8	2.3	-0.0	1.0	0.6	1.5	0.4	0.9	0.9
Maternal smoking around birth	0.6	0.8	2.3	-0.2	0.3	-1.3	-1.1	-1.5	0.2	0.6
Had menopause	0.6	0.7	2.0	0.4	1.2	-0.3	0.9	0.5	1.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.1	-0.3	-0.8	-1.0	-2.0	-0.4	-1.6	-0.8
Arm fat percentage (right)	0.6	2.2	6.6	2.0	1.4	1.3	0.8	0.5	-0.2	2.6
Arm fat mass (right)	0.6	2.5	5.2	2.1	1.2	1.9	0.9	1.3	-0.3	2.3
Birth weight	0.6	1.2	5.2	1.0	0.3	1.5	-0.2	2.3	-0.2	0.0
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.1	0.8	1.4	1.0	-0.4	1.2	0.0	0.1
Body fat percentage	0.6	2.6	5.5	2.3	1.6	1.9	0.4	0.7	-0.6	2.3
Eye problems/disorders: None of the above	0.6	0.7	1.7	-1.3	-0.8	-0.7	-1.2	0.1	-0.2	-0.7
Neck or shoulder pain in last month	0.6	0.9	4.1	-0.3	2.0	-0.5	0.8	-0.9	0.5	-0.0
Migraine (self-reported)	0.6	0.8	2.0	0.7	1.1	1.2	1.4	0.0	0.4	0.4
Alcohol intake frequency.	0.6	1.4	3.9	2.0	0.9	1.0	0.2	0.9	-0.2	1.8
Number of full sisters	0.6	0.8	2.3	1.5	0.3	1.4	0.5	0.9	0.0	0.2
Age at last live birth	0.6	0.8	2.9	0.1	-0.6	1.7	0.3	1.3	-0.6	0.1
Family relationship satisfaction	0.6	0.8	1.7	0.6	0.9	0.7	1.3	-0.9	0.6	0.9
Medication: Aspirin	0.6	0.8	2.4	0.3	1.4	0.7	-0.9	-0.5	-1.5	-0.1
Arm fat percentage (left)	0.6	2.5	7.3	2.2	1.4	1.6	0.5	0.5	-0.5	2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.1	-0.7	0.1	-0.8	-1.0	0.7	-0.5	-1.1
Medication for cholesterol	0.6	0.9	2.6	-0.0	-0.6	1.0	-0.7	1.6	-1.1	-0.8
Medication: Gliclazide	0.6	0.7	1.8	-1.2	0.4	-0.9	0.2	-0.5	0.6	-1.3
Arm fat mass (left)	0.6	2.4	5.5	2.2	1.1	1.9	0.6	1.1	-0.5	2.3
Medication: Blood pressure	0.6	1.2	4.1	-0.6	0.9	-0.8	2.0	-0.3	1.5	-0.0
Medication: Paracetamol	0.6	1.0	3.1	-0.9	-0.4	-0.9	1.8	-0.6	1.1	0.3
Risk taking	0.6	0.8	2.0	-1.4	-0.6	-1.0	1.0	-1.0	0.5	-0.1
Cholesterol lowering medication	0.6	0.8	3.6	-0.1	0.4	-1.1	0.9	0.2	1.9	-0.2
Depression (Nagel 2018)	0.5	0.7	1.6	-0.5	0.7	-1.3	-0.1	-1.3	-0.6	0.7
Breast Cancer	0.5	1.2	4.9	0.6	0.6	0.9	0.3	2.2	-0.9	-0.7
Ovarian Cancer	0.5	0.6	1.7	-0.6	-1.1	0.7	0.7	0.4	0.1	-1.3
BMI	0.5	3.1	6.5	2.5	2.0	1.6	-0.1	1.3	-1.0	2.5
Smoking Status	0.5	1.3	5.3	-0.5	0.2	-0.8	-1.2	-2.3	-0.4	1.1
Angina	0.5	0.7	2.4	0.7	1.5	0.5	0.8	-0.6	-0.6	0.8
Leg fat-free mass (left)	0.5	2.7	7.2	1.7	-0.4	2.7	0.6	2.5	-0.9	1.0
Average weekly fortified wine intake	0.5	0.6	2.3	-0.6	-0.4	0.9	0.5	1.5	-0.5	-0.5
Body mass index (BMI)	0.5	2.1	4.6	1.9	1.6	1.2	1.3	0.9	0.3	2.1
Leg predicted mass (left)	0.5	2.7	7.2	1.8	-0.4	2.7	0.5	2.4	-1.0	1.0
Waist circumference	0.5	2.0	5.5	1.5	0.7	2.2	0.8	2.3	-0.4	0.4
Had other major operations	0.5	0.6	1.1	-0.9	0.7	-0.6	0.4	-1.1	0.8	-0.9
Weight	0.5	2.6	5.8	2.1	0.5	2.4	0.6	2.0	-0.7	1.6
Hip circumference	0.5	2.1	4.4	1.6	1.0	2.1	0.7	2.1	-0.4	1.2
Worrier / anxious feelings	0.5	1.0	2.5	1.1	0.5	0.1	-1.6	-0.3	-1.4	1.0
Noisy workplace	0.5	0.6	1.1	1.0	0.5	0.2	0.8	-0.4	0.9	1.1
Pulse wave Arterial Stiffness index	0.5	0.5	2.4	-0.7	-1.6	-0.2	-0.3	0.5	-0.2	-0.7
Medication: Paracetamol	0.5	0.8	1.7	0.3	0.8	-0.7	1.2	-1.1	0.6	1.3
Arm fat-free mass (right)	0.5	2.3	6.0	1.5	-0.4	2.4	0.0	2.4	-1.3	0.3
Comparative body size at age 10	0.5	1.3	2.7	1.7	1.0	0.9	-0.3	1.5	-0.7	1.3
Pulse wave peak to peak time	0.5	0.5	1.9	0.8	1.4	0.2	0.0	-0.5	0.0	0.9
Mean time to correctly identify matches	0.5	1.0	4.9	1.1	2.2	0.2	-0.3	-0.2	-0.2	1.0
Whole body fat mass	0.5	2.3	4.5	2.1	0.9	2.1	0.5	1.3	-0.6	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.5	1.2	0.4	1.2	0.4	0.4	-0.4	0.7
Leg fat-free mass (right)	0.5	2.8	7.7	1.8	-0.3	2.8	0.5	2.6	-1.0	0.9
Back pain experienced in last month	0.5	0.7	2.0	0.3	-1.3	0.8	-0.0	-1.4	-0.0	0.5
Mineral and other dietary supplements	0.5	0.7	3.3	0.3	-0.7	-0.6	-0.1	-0.8	-0.4	1.8
Osteoporosis (self-reported)	0.5	0.7	1.2	0.6	0.8	0.0	1.0	-0.7	1.1	1.0
Medication: Aspirin	0.5	0.6	1.9	-0.1	1.2	0.8	-0.7	-0.1	-1.4	-0.4
Leg predicted mass (right)	0.5	2.8	7.8	1.8	-0.4	2.8	0.6	2.5	-0.9	0.9
Mother’s age at death	0.5	0.6	2.0	-0.5	-0.2	-0.2	1.4	-0.8	0.8	-0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.6	-1.0	-0.2	0.2	0.8	-0.4	0.8	-1.3
High cholesterol (Self-reported)	0.5	0.8	2.7	-0.7	-0.6	-0.7	1.1	0.1	1.6	-0.8
Fractured/broken bones in last 5 years	0.5	0.7	1.8	-0.1	-1.3	-1.2	-0.6	-0.7	-0.5	0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	0.5	0.1	0.3	0.5	-1.0	0.8	1.2
Blood White Count	0.4	2.7	7.6	0.5	1.9	1.2	2.8	0.2	2.0	1.2
Waist Hip Ratio (WHR)	0.4	1.6	5.0	-1.8	-1.4	-0.6	-0.7	0.2	-0.4	-2.2
Hypothyroidism (self reported)	0.4	1.0	3.2	0.1	1.0	1.3	0.8	1.8	0.4	-0.4
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.8	-1.3	-0.2	-0.9	0.1	-0.9	-0.5	0.3
Ever had hysterectomy (womb removed)	0.4	0.5	1.4	-0.5	0.3	-1.2	0.1	-0.9	0.9	0.4
Systolic blood pressure, automated reading	0.4	1.2	2.7	-1.6	-0.1	-1.0	1.5	-0.0	1.2	-0.9
Impedance of leg (right)	0.4	2.0	3.8	-1.4	-1.1	-1.4	-1.9	-1.5	-1.0	-1.3
Current tobacco smoking	0.4	0.6	2.1	0.3	-0.7	0.4	-1.4	-0.1	-1.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	-0.5	0.6	-1.2	0.4	-1.3	-0.1	0.5
Age when periods started (menarche)	0.4	1.0	2.4	0.2	-0.7	-0.7	-1.2	-1.4	-1.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.7	0.0	-0.8	-0.0	-1.6	0.0	-1.5	-0.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.8	1.4	0.1	1.7	0.5	0.4	-0.3	0.7
Supplements: Glucosamine	0.4	0.6	1.9	-1.1	-0.3	0.7	-0.4	0.3	-0.3	-1.4
Medication: Atenolol	0.4	0.5	1.3	-0.0	-0.1	0.9	1.1	0.2	-1.0	0.2
Sitting height	0.4	2.9	9.6	2.0	-0.1	3.1	-0.9	0.4	-2.2	1.1
Impedance of leg (left)	0.4	1.9	3.2	-1.5	-1.0	-1.4	-1.8	-1.4	-0.9	-1.5
Past tobacco smoking	0.4	0.7	2.2	-0.2	-0.9	-0.0	-0.1	1.4	0.2	-1.5
Allergy	0.4	1.0	2.2	-1.5	-0.9	-1.3	0.2	-0.2	0.9	-1.2
Diabetes (self-reported)	0.4	0.7	2.9	0.4	0.7	-0.3	-1.7	-0.4	-0.7	0.6
Medication: Simvastatin	0.4	0.6	2.1	0.2	0.3	-1.1	0.9	-0.0	1.4	0.2
Trunk fat-free mass	0.4	2.1	7.2	0.7	-1.2	2.1	0.2	2.7	-0.9	-0.2
Father’s age at death	0.4	0.6	1.3	0.2	1.1	0.9	-0.4	0.6	-1.1	-0.1
Trunk predicted mass	0.4	2.1	7.0	0.7	-1.3	2.1	0.3	2.6	-0.9	-0.2
Standing height	0.4	4.4	7.8	0.8	-2.5	2.8	-1.6	2.6	-2.5	-1.1
Loud music exposure frequency	0.4	0.4	0.8	-0.9	-0.6	-0.5	-0.7	-0.2	-0.6	-0.7
High blood pressure (siblings)	0.4	0.5	1.0	0.7	1.0	0.8	0.9	0.3	0.8	0.2
Leg fat percentage (right)	0.4	1.3	2.8	1.5	1.7	1.0	0.2	0.6	-0.3	1.6
Number of full brothers	0.4	0.5	1.8	-0.6	-0.8	-0.2	1.3	-0.0	0.4	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.0	-1.4	0.1	0.3	0.3	-0.4	0.5	-0.7
Angina (self-reported)	0.4	0.6	1.5	0.3	1.2	0.1	1.0	-1.1	-0.2	0.4
Leg fat mass (right)	0.4	1.7	3.4	1.7	0.9	1.6	0.2	1.0	-0.8	1.8
Arm predicted mass (right)	0.4	2.1	6.4	1.2	-0.8	2.3	0.1	2.5	-1.1	0.2
Comparative height size at age 10	0.4	2.3	4.5	-1.0	-2.0	0.8	1.2	2.1	0.7	-1.9
Leg pain on walking	0.4	0.5	1.2	1.1	0.2	0.3	0.3	1.1	-0.1	0.7
Whole body fat-free mass	0.4	2.5	7.5	1.3	-0.8	2.5	0.3	2.7	-1.0	0.4
Commuting to job workplace: Walk	0.4	0.5	1.9	0.4	-0.5	-0.7	-1.4	0.5	0.2	0.4
Breast cancer (self-reported)	0.4	0.5	1.6	0.2	-0.2	-1.3	0.0	-0.6	1.1	0.2
Whole body water mass	0.4	2.4	6.9	1.2	-0.9	2.5	0.4	2.6	-0.9	0.3
Supplements: Fish oil (including cod liver oil)	0.4	0.6	2.3	-0.1	-0.5	0.1	-1.2	-0.1	-0.3	-1.5
Medication: Bendroflumethiazide	0.4	0.6	1.4	-0.5	1.0	-0.9	0.7	-0.2	1.2	0.0
Basal metabolic rate	0.4	2.5	7.3	1.4	-0.6	2.5	0.5	2.7	-0.9	0.6
Arm fat-free mass (left)	0.4	1.8	6.4	1.1	-0.4	2.0	0.9	2.5	-0.2	0.2
Leg fat mass (left)	0.4	1.6	3.0	1.7	0.9	1.7	0.3	0.9	-0.8	1.7
Arm predicted mass (left)	0.4	2.0	6.4	1.2	-0.5	2.2	0.8	2.5	-0.3	0.4
Bipolar Disorder (2018)	0.3	0.5	1.2	-0.3	0.6	-0.7	-0.4	-1.1	-0.7	-0.8
Worry (Nagel 2018)	0.3	0.7	2.9	-0.6	0.4	-0.7	-0.7	-1.7	-0.4	0.3
Heel T-Score	0.3	2.0	7.3	-1.2	-0.2	-0.1	-0.7	1.9	-1.1	-2.7
Allergy or Eczema	0.3	0.9	2.6	1.1	-0.5	1.6	1.2	0.8	0.0	0.1
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.1	0.1	0.7	0.6	1.1	0.1	0.5	-0.3
Fed-up feelings	0.3	0.6	2.3	0.2	0.6	0.0	-1.5	-0.5	-1.0	0.2
Nervous feelings	0.3	0.5	1.7	-0.6	-0.5	-0.5	-1.1	-1.3	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-0.2	-1.1	0.4	0.3	-0.6	0.2	-1.2
Length of working week for main job	0.3	0.3	0.6	0.8	0.6	-0.1	0.2	0.7	0.5	0.7
Birth weight of first child	0.3	0.6	3.4	0.2	-1.8	-0.2	-0.6	-0.5	-0.3	-0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.6	-0.6	1.0	0.5	0.3	1.1	0.5	-1.2
Worry too long after embarrassment	0.3	0.5	2.0	-0.3	-0.4	-0.1	-1.4	-0.6	-0.7	-0.4
Number of children fathered	0.3	0.4	1.3	0.4	-0.0	1.0	1.1	0.2	-0.0	0.1
Pulse rate, automated reading	0.3	1.1	1.8	1.1	1.3	-0.3	0.9	-0.4	1.4	1.2
Average weekly red wine intake	0.3	0.5	1.0	-0.6	1.0	0.1	0.9	-0.9	0.4	-0.5
Diabetes diagnosed by doctor	0.3	0.5	1.1	0.5	0.8	-0.4	-1.0	-0.5	-0.4	0.8
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	0.1	1.0	-0.3	0.2	-0.7	-0.3	0.7
Leg fat percentage (left)	0.3	1.2	2.8	1.4	1.7	1.0	0.3	0.5	-0.5	1.5
Diastolic blood pressure, automated reading	0.3	0.8	3.9	-0.4	0.4	0.2	2.0	-0.1	1.2	-0.0
Unable to work because of sickness or disability	0.3	0.3	1.0	0.5	0.7	-0.1	0.0	0.8	0.0	1.0
Pain experienced in last month	0.3	0.5	1.9	-0.7	-1.4	-0.4	0.7	0.4	0.6	-0.4
Prostate Cancer	0.2	0.3	0.9	-0.6	-0.2	-0.3	-0.7	0.1	-1.0	-0.4
Bipolar Disorder (2011)	0.2	0.2	0.5	0.3	0.7	0.3	0.5	0.4	0.1	-0.4
Primary Biliary Cirrhosis	0.2	0.3	1.0	-0.1	-0.9	0.1	0.6	-0.1	1.0	0.3
Ulcerative Colitis	0.2	0.3	0.9	0.4	0.4	0.2	-0.9	-0.8	-0.1	0.6
Systolic Blood Pressure	0.2	1.1	2.7	-1.7	-1.1	-0.7	0.9	0.9	0.8	-0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.0	0.1	0.9	-0.8	-0.3	-1.0	-0.2	0.8
Medication: Metformin	0.2	0.3	0.9	0.1	1.0	-0.3	-0.6	-0.4	0.5	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.7	0.3	0.1	0.2	0.6	-0.9	-0.0	0.6
Medication: Levothyroxine sodium	0.2	0.4	0.7	-0.7	0.8	-0.9	-0.0	-0.3	0.6	-0.4
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.3	0.9	-0.1	-0.3	0.9	-0.2	0.2
Heart attack	0.2	0.2	1.2	-0.1	1.1	-0.3	0.0	0.2	-0.5	-0.4
Medication: Ramipril	0.2	0.3	0.8	-0.5	-0.2	-0.9	0.6	-0.1	0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	-0.0	1.0	-0.1	0.6	-0.6	-0.1	0.4
Falls in the last year	0.2	0.3	0.8	-0.1	0.7	0.5	0.9	-0.7	-0.1	0.3
Impedance of arm (left)	0.2	1.0	3.9	0.3	-0.6	0.2	-2.0	-0.8	-1.4	0.1
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	0.5	1.0	0.8	0.4	0.7	0.1	1.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.3	-0.6	-1.1	-0.3	-0.4	0.4	-0.5	-0.5
Glaucoma (self-reported)	0.2	0.2	0.4	-0.2	0.3	-0.4	0.2	0.5	-0.7	0.6
Exposure to tobacco smoke outside home	0.2	0.2	0.5	-0.4	-0.3	0.4	-0.7	-0.3	-0.6	-0.4
Health satisfaction	0.2	0.3	0.8	0.9	0.5	0.5	-0.3	0.1	-0.5	0.8
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	-0.0	-0.2	-0.3	-0.5	0.5	-0.8	-0.2
Heart disease (mother)	0.2	0.2	0.6	-0.5	0.3	0.1	0.5	-0.7	0.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.9	-0.1	0.2	-0.3	0.9	-0.5	-0.3	-0.4
Friendships satisfaction	0.2	0.3	0.9	-0.1	0.4	0.0	0.5	-1.0	0.4	-0.6
Smoking status: Current	0.2	0.3	1.0	-0.4	-0.9	-0.1	-1.0	-0.2	-0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.2	-0.1	-1.1	0.7	-0.4	-0.2	-0.9	0.0
Commuting to job workplace: Public transport	0.2	0.2	0.4	-0.6	-0.5	-0.4	-0.1	-0.5	0.6	-0.3
Number of operations (self-reported)	0.2	0.3	1.2	-0.7	1.1	-0.3	0.5	-0.3	0.5	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.7	0.0	-0.2	0.8	-0.1	0.4	0.3	-0.6
Myopia	0.2	0.3	0.8	0.2	0.6	0.4	0.9	0.3	0.5	0.7
Impedance of whole body	0.2	1.2	4.2	-0.1	-0.6	-0.3	-2.0	-1.2	-1.5	-0.3
Blood Eosinophil Count	0.1	0.7	2.8	-0.9	-0.1	-0.6	0.6	-1.7	0.4	0.2
Blood Red Count	0.1	0.6	2.4	0.8	-0.1	1.0	0.5	1.6	-0.0	0.1
Height	0.1	2.5	4.7	0.9	-1.2	2.2	-1.6	1.9	-2.0	-0.2
Lung FEV1/FVC ratio	0.1	0.6	1.5	-0.5	-1.2	-1.0	0.2	0.7	0.3	-0.9
Lung FVC	0.1	0.7	2.1	-0.7	-0.9	1.0	-0.2	0.5	-1.5	-0.5
Hair Pigment	0.1	3.8	7.7	-2.1	0.5	-2.3	2.1	-2.1	2.8	0.0
Tanning	0.1	1.8	3.6	1.4	-0.1	1.4	-0.7	1.0	-1.8	1.9
Impedance of arm (right)	0.1	0.4	1.4	0.1	-0.5	0.1	-1.2	-0.8	-0.8	0.1
Medication: Cholesterol lowering	0.1	0.1	0.2	0.5	0.4	-0.2	-0.2	-0.5	-0.1	-0.1
Medication: Blood pressure	0.1	0.2	1.4	0.0	0.2	-0.1	0.5	-0.0	1.2	-0.1
Overall health rating	0.1	0.2	0.8	0.4	0.9	-0.2	0.1	-0.4	0.4	-0.2
Had major operations	0.1	0.2	0.4	0.2	0.7	0.4	0.5	-0.0	-0.2	0.4
Supplements: Vitamin C	0.1	0.2	0.3	0.5	-0.3	0.5	0.6	-0.3	0.3	0.1
Average weekly champagne plus white wine intake	0.1	0.2	0.9	0.1	-0.3	0.9	0.3	-0.1	-0.2	0.1
Alcohol drinker status: Never	0.1	0.1	0.3	-0.1	0.5	0.0	-0.5	0.2	0.3	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.1	0.8	-0.4	-0.2	0.0	-0.6	-0.4

Hub : Genes

PPP4R1

Models

Trait associations