Hub : Genes

PQLC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1070	0.0330	4.4e-07	0.015	0.067	0.065	0.074	0.065	5.1e-03	1.3e-08	2.4e-08	2.8e-09	2.3e-08
2	GTEx	Artery Tibial	0.0780	0.0362	6.6e-03	0.022	NA	0.022	NA	0.027	7.3e-03	NA	6.9e-03	NA	3.1e-03
3	GTEx	Brain Cerebellar Hemisphere	0.3130	0.0870	2.2e-04	0.006	NA	0.058	NA	0.135	2.1e-01	NA	1.4e-02	NA	2.5e-04
4	GTEx	Brain Cerebellum	0.2460	0.1070	5.9e-03	0.007	NA	0.013	NA	0.004	1.9e-01	NA	1.3e-01	NA	2.5e-01
5	GTEx	Brain Frontal Cortex BA9	0.2947	0.1055	2.0e-03	-0.001	NA	0.002	NA	0.003	3.5e-01	NA	2.9e-01	NA	2.6e-01
6	GTEx	Brain Putamen basal ganglia	0.1680	0.0760	8.1e-03	0.086	NA	0.006	NA	0.009	4.5e-03	NA	2.3e-01	NA	1.9e-01
7	GTEx	Cells Transformed fibroblasts	0.1310	0.0550	4.6e-03	0.018	NA	0.033	NA	0.019	1.5e-02	NA	1.7e-03	NA	1.4e-02
8	GTEx	Lung	0.2158	0.0512	4.4e-10	0.136	NA	0.148	NA	0.155	1.4e-10	NA	2.2e-11	NA	6.2e-12
9	GTEx	Nerve Tibial	0.0994	0.0501	9.1e-03	-0.001	NA	0.025	NA	0.003	4.0e-01	NA	6.9e-03	NA	1.8e-01
10	GTEx	Thyroid	0.1100	0.0400	3.3e-04	0.068	NA	0.051	NA	0.059	6.3e-06	NA	9.0e-05	NA	2.6e-05
11	GTEx	Whole Blood	0.0550	0.0250	9.2e-03	0.008	NA	0.022	NA	0.013	5.0e-02	NA	3.9e-03	NA	1.9e-02
12	YFS	Blood	0.3162	0.0340	0.0e+00	0.241	0.282	0.285	0.276	0.273	6.9e-78	4.2e-93	2.9e-94	1.2e-90	1.2e-89

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.6	2.5	13.9	0.4	-3.7	-1.1	0.4	-0.1	-1.1	-0.1	-2.1	-0.7	-2.7	-0.8	0.5
Bipolar Disorder or Schizophrenia	2.2	5.5	16.4	1.7	-3.9	2.5	4.0	2.2	0.5	-1.3	-1.9	0.9	-0.9	0.3	3.6
Depressed Affect (Nagel 2018)	1.2	2.5	11.2	1.6	-0.9	3.3	1.6	2.0	1.2	-1.8	-0.4	0.7	0.5	-1.7	0.9
Depression (Nagel 2018)	0.8	1.2	4.2	0.2	-0.4	1.1	0.6	1.0	0.5	-1.6	1.1	0.6	1.8	-0.2	2.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.5	-2.1	1.2	-1.5	-1.1	-1.5	-1.5	1.5	1.0	1.0	-1.2	0.4	-1.4
Neuroticism (Nagel 2018)	2.5	5.9	18.8	2.8	-2.1	4.3	1.7	3.5	1.9	-3.0	-1.8	0.0	-0.2	-2.4	1.8
Schizophrenia (2018)	3.4	7.0	23.5	1.8	-2.0	4.1	4.8	2.9	1.7	-1.6	-0.7	1.7	1.1	1.0	4.2
Schizophrenia vs Biploar Disorder	1.8	2.4	6.3	2.1	-0.3	2.5	2.4	1.7	2.5	-0.8	-1.2	0.3	0.7	-0.6	-0.2
Worry (Nagel 2018)	2.8	5.8	18.0	2.5	-2.0	4.2	1.9	2.8	2.9	-3.6	-1.8	-0.7	0.3	-1.2	2.1
Alzheimer’s Disease (in mother)	1.2	1.3	2.9	0.2	-1.6	-1.1	-0.1	-1.6	-0.5	1.1	-1.7	-0.9	-1.6	-0.8	-1.1
Alzheimer’s Disease (in father)	1.6	1.7	7.6	-0.8	-0.1	0.5	0.4	-0.8	2.8	-2.1	0.4	-0.2	1.0	1.6	1.6
Alzheimer’s Disease (including proxy)	0.8	1.2	4.1	-0.3	-1.8	-1.2	-0.2	-2.0	1.0	-0.6	-1.5	-1.0	-1.1	0.1	-0.3
Crohns Disease (2017)	2.4	5.2	14.7	2.2	-1.9	-3.8	-1.2	0.9	-0.5	1.1	-3.5	-0.7	-3.5	-0.7	-3.1
Irritable Bowel Disease (IBD)	2.4	5.6	16.3	2.2	-3.3	-3.2	-1.2	1.0	-0.1	0.6	-4.0	-1.0	-4.0	-0.3	-2.3
Ulcerative Colitis (UC)	1.2	2.3	8.7	1.3	-2.9	-1.3	-0.8	0.9	0.3	-0.4	-2.6	-1.0	-2.5	0.4	-0.6
Major Depression (MDD)	1.5	1.8	13.5	0.0	0.1	0.6	-0.8	0.4	0.0	-3.7	0.2	0.0	2.3	-0.0	1.3
Reaction Time	1.2	2.3	8.1	0.4	-2.0	2.8	2.4	0.8	1.1	0.1	-1.2	-0.6	-0.8	-2.4	0.2
Verbal and Numeric Reasoning (VNR)	0.5	1.1	6.6	0.2	1.1	-2.6	-0.8	0.8	0.7	1.0	-0.2	-0.2	-1.4	0.2	-0.8
Breast Cancer	0.6	1.4	2.9	0.3	1.1	1.2	0.8	1.4	1.0	0.3	1.5	1.7	1.2	1.5	1.3
Ovarian Cancer	0.4	0.5	1.6	0.5	-0.5	-0.0	1.0	-1.0	1.2	-0.8	-0.4	-0.8	0.2	0.9	-0.5
Prostate Cancer	0.5	0.7	2.0	-0.7	0.7	-1.0	-1.0	-0.6	-1.0	0.9	1.0	-0.1	0.6	-0.6	-1.4
Age at First Birth	0.8	1.1	7.2	-0.4	-1.2	-0.6	0.5	0.6	-0.2	1.0	-1.4	0.2	-2.7	0.4	-0.5
Bipolar Disorder (2011)	2.4	2.3	9.0	0.8	-3.0	-0.0	2.2	0.2	0.5	-0.2	-2.5	-0.3	-2.4	-0.3	0.8
Body Mass Index (BMI) (2010)	0.7	0.9	4.2	2.0	-0.6	-0.1	0.5	1.6	1.3	-0.6	-1.0	-0.6	-0.1	-0.6	-0.2
Coronary Artery Disease (CAD)	0.8	1.0	3.0	0.2	0.9	-0.5	-1.5	0.7	-1.7	1.0	-0.5	-0.7	-0.4	-1.4	-0.9
Crohns Disease (2012)	2.2	3.5	12.1	2.1	-0.7	-2.9	-1.1	-0.3	-0.4	1.2	-2.3	0.3	-2.1	-2.1	-3.5
Mean Putamen Volume	0.8	1.0	3.3	-1.5	0.2	-0.7	-1.3	-1.7	-0.5	1.8	0.2	0.2	-0.6	0.4	-0.4
Fasting Glucose	0.3	0.3	1.0	-0.8	0.5	0.9	0.7	-1.0	-0.0	0.5	-0.1	0.5	0.3	-0.3	-0.2
HbA1C	1.2	1.3	5.4	0.7	-0.9	-1.9	-2.3	0.2	-0.2	1.5	-0.5	0.3	-0.8	1.4	0.0
HDL Cholesterol	0.3	0.5	3.2	0.6	-0.2	-0.1	0.7	-0.4	0.7	-1.0	-0.4	-0.4	-0.0	1.8	0.6
LDL Cholesterol	1.9	3.0	15.1	-0.8	-2.5	-2.3	-0.3	-1.3	-1.1	-1.6	-1.5	-3.9	-0.2	-0.1	0.3
Lupus	2.0	3.0	9.7	-0.4	2.0	-2.5	-3.1	-1.2	-1.7	2.5	1.4	0.8	0.8	0.8	-0.9
Neuroticism (2016)	1.6	2.3	11.2	0.1	-0.5	1.9	1.4	0.4	1.7	-3.3	0.5	-0.2	1.8	-0.9	1.6
Primary Biliary Cirrhosis	0.6	0.9	2.0	-0.2	-1.3	-0.1	-0.4	0.8	-1.3	1.3	-1.0	1.4	-1.1	-0.5	-0.5
Rheumatoid Arthritis	0.6	0.9	3.3	-0.1	0.4	0.4	-0.1	1.8	1.1	-1.8	0.4	1.0	0.8	-0.8	0.2
Schizophrenia (2014)	1.8	4.1	12.1	1.3	-2.7	3.1	3.5	1.8	0.8	-0.7	-1.7	0.9	-0.1	0.5	3.1
Triglycerides	0.5	0.9	2.8	0.0	-1.1	-1.7	-0.9	-0.6	0.1	0.0	-1.6	-1.2	-0.6	-0.8	-0.5
Type 2 Diabetes (T2D) (2012)	1.7	1.9	6.2	-1.8	1.5	-2.5	-1.0	-2.4	-1.5	0.0	1.0	0.2	1.0	0.5	-0.8
Ulcerative Colitis	0.8	1.1	3.6	0.9	-0.9	-1.9	-0.8	0.6	-0.3	0.6	-1.0	-0.2	-1.7	-1.1	-1.4
Blood Eosinophil Count	0.3	2.5	7.5	-1.1	2.7	0.7	-0.4	-1.4	1.0	0.9	2.7	2.6	1.6	0.4	0.0
Blood Platelet Count	0.4	5.2	15.2	1.2	-2.7	-0.9	-0.0	-0.1	3.8	0.6	-3.9	0.1	-2.6	3.8	1.1
Blood Red Count	0.1	1.3	6.8	0.2	-0.4	-2.6	-0.4	-1.7	1.1	1.0	-1.2	-0.8	-0.4	0.7	-0.6
Blood White Count	1.0	7.4	28.5	3.2	-0.3	5.3	2.5	1.9	3.3	-2.1	0.4	3.4	3.3	-1.0	1.5
Heel T-Score	0.3	2.6	7.4	-1.3	2.5	0.1	0.2	0.4	0.9	-1.9	2.0	-1.9	2.7	-1.7	1.1
BMI	0.2	1.4	4.5	1.0	-0.7	0.1	0.9	-2.1	0.8	0.6	-1.7	0.0	-0.1	-2.1	-1.6
Height	0.2	4.1	13.8	-0.4	1.9	-2.0	-0.8	0.3	0.5	3.7	1.9	2.9	-0.4	3.7	-0.9
Waist Hip Ratio (WHR)	0.3	1.5	5.2	1.9	-0.9	0.5	-0.1	0.8	1.0	-1.4	-1.5	0.4	0.3	2.3	1.5
Systolic Blood Pressure	0.3	1.3	5.2	1.6	-1.3	-0.1	-0.4	-1.1	0.7	0.4	-2.3	-0.9	-1.6	-0.1	-0.9
Smoking Status	1.4	3.3	15.0	3.9	1.2	2.6	0.8	0.3	2.0	-1.6	-0.4	1.4	2.0	-1.6	-0.6
Allergy or Eczema	0.8	2.2	7.8	-2.2	0.5	-2.1	-0.5	-1.8	-0.8	-0.8	0.8	-1.4	0.6	2.8	1.2
Cardiovascular Disease	0.6	1.8	4.5	2.1	-1.0	-0.4	-2.1	-1.2	1.5	-1.1	-1.4	0.3	-0.0	-1.6	-1.4
Hypothyroidism (self reported)	0.4	1.0	3.3	0.9	-0.1	1.8	1.2	-0.2	1.1	-1.1	-1.0	1.3	-0.0	-0.7	-1.0
Respiratory disease	0.8	1.8	8.9	-0.1	1.8	-0.6	-1.0	-1.0	-0.0	0.3	2.3	1.1	3.0	-0.7	-0.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	6.5	1.8	-0.8	-2.6	-0.8	-0.8	-0.5	-0.3	-1.1	-0.7	-0.1	1.2	-0.4
Lung FEV1/FVC ratio	0.1	0.7	1.6	0.9	-0.3	0.5	0.6	1.3	1.1	0.5	-1.1	-0.5	-0.9	-1.0	0.3
Lung FVC	0.5	2.4	9.5	0.4	1.1	3.1	1.0	1.3	-1.4	1.9	1.0	2.1	-0.3	-1.5	-1.5
Neuroticism	1.6	3.8	11.9	2.0	-1.2	3.4	1.2	3.1	1.4	-2.3	-1.2	-0.3	-0.2	-2.0	2.0
Chronotype (morning person)	0.9	2.0	8.5	-2.3	-1.0	-0.5	0.1	-0.2	-1.4	0.0	-1.7	-2.9	-1.8	0.9	0.7
Hair Pigment	0.0	0.9	4.3	0.8	0.3	-0.1	-0.6	0.2	0.5	0.8	-0.7	-0.6	-0.3	-2.1	-2.0
Tanning	0.1	1.6	8.4	-0.9	0.9	-2.9	-1.3	-1.0	0.9	0.9	0.3	0.5	0.2	0.7	-2.0
Hand grip strength (left)	0.8	2.0	7.5	-0.7	2.7	1.2	0.4	-0.2	-0.1	1.6	2.2	1.8	1.5	-0.9	-0.4
Number of treatments/medications taken	0.5	0.9	4.6	2.2	0.4	1.1	-0.3	0.0	-0.8	-0.5	0.3	-0.0	1.3	-1.5	-0.5
Average weekly spirits intake	0.4	0.5	1.8	1.2	-0.8	-0.3	0.7	-0.3	1.1	-1.3	-0.3	0.6	0.2	0.1	-0.4
Sensitivity / hurt feelings	2.1	3.6	13.5	1.9	-0.9	2.6	1.8	3.7	0.5	-1.1	-1.5	-0.8	-0.5	-1.6	2.8
Frequency of depressed mood in last 2 weeks	1.5	2.1	8.8	-0.1	0.5	1.7	0.7	1.7	0.8	-1.8	1.2	0.8	1.7	0.7	3.0
Hearing difficulty/problems: Yes	0.3	0.5	1.7	-0.5	0.9	0.5	-0.6	0.1	0.0	-0.7	1.1	-0.4	1.3	0.1	0.5
Relative age of first facial hair	0.7	1.5	6.6	2.6	0.6	0.4	1.1	1.6	1.1	0.7	1.0	0.4	1.8	-1.1	0.2
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.5	1.5	0.8	-0.1	-1.7	1.9	-1.0	0.8	-0.0	-1.8	-0.2	-1.1	-0.4
Ever used hormone-replacement therapy (HRT)	1.3	1.6	6.6	-1.0	1.4	0.5	-0.1	-0.7	-2.6	2.2	1.5	0.3	0.9	-1.3	-0.2
Ever had hysterectomy (womb removed)	0.8	1.0	3.4	1.8	0.6	1.1	0.2	1.2	-0.8	1.4	0.1	-0.6	0.2	-1.3	-0.4
Systolic blood pressure, automated reading	0.3	0.9	3.1	0.9	-0.5	-0.1	-1.2	-0.6	-0.7	1.3	-1.2	-0.1	-1.8	-0.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	4.0	-0.2	-0.7	-0.6	-1.1	-0.9	-2.0	0.8	0.4	0.3	-0.1	0.1	0.1
Angina	0.4	0.6	1.9	1.4	0.2	1.3	-0.2	0.8	-0.3	-0.0	0.3	-0.3	0.9	-1.1	-0.3
Medication for hormone replacement therapy	1.6	1.8	7.7	-0.5	0.5	0.6	-0.9	0.1	-2.8	1.2	1.3	-1.5	1.2	-2.2	0.5
Vitamin and mineral supplements	1.0	1.4	4.5	-1.4	0.3	-2.1	-0.8	-1.1	-2.1	0.8	0.1	-0.0	-1.3	1.0	-0.4
Supplements: Zinc	0.4	0.4	1.7	-1.2	-0.4	-0.0	0.4	-0.4	-0.7	0.1	-0.1	1.3	-0.3	0.5	0.7
Medication: Co-codamol	1.0	1.1	5.0	0.8	-0.7	1.2	0.6	0.7	0.9	-1.4	-0.1	2.2	0.6	0.6	1.3
Medication: Metformin	1.6	2.2	8.3	0.7	-1.1	-2.9	-1.9	-2.0	-1.4	0.8	-0.9	-1.5	-0.1	1.9	0.1
Diabetes (father)	0.3	0.4	1.7	-0.5	0.0	0.6	0.4	0.7	1.1	0.2	0.5	1.3	0.3	0.6	-0.1
Diabetes (mother)	0.7	0.9	5.5	2.4	0.2	-0.2	0.7	0.0	0.8	0.7	-0.0	0.9	0.5	-0.8	-1.4
Severe depression (siblings)	0.7	0.8	2.9	1.0	-0.7	0.5	-0.2	1.2	-0.7	0.7	-0.1	-1.7	-0.2	-1.1	0.8
Pack years adult smoking proportion	0.6	0.9	2.6	1.5	-1.1	0.3	0.7	-0.1	0.8	-0.8	-1.4	-1.6	0.2	0.1	0.4
Impedance of leg (right)	1.0	4.9	15.7	3.3	-2.3	2.2	0.5	2.5	4.0	-3.1	-1.4	2.0	0.3	0.2	0.8
Leg fat-free mass (left)	0.3	1.7	7.1	-1.3	1.3	-1.1	0.2	-2.2	-0.8	2.7	0.4	0.6	-0.3	0.6	-1.5
Trunk fat percentage	0.3	1.1	3.9	0.9	-0.3	0.9	0.4	-2.0	0.8	-0.2	-1.0	1.3	0.1	-1.5	-1.5
Hand grip strength (right)	1.1	3.0	10.1	-0.1	3.2	0.9	-0.3	0.3	-0.7	1.7	3.1	2.0	2.0	-1.7	-1.3
Townsend deprivation index at recruitment	0.7	1.0	5.8	-0.8	1.3	2.4	0.8	-0.1	0.2	-0.7	0.2	0.8	0.9	-0.1	0.8
Current tobacco smoking	0.7	1.2	3.8	1.8	-0.5	2.0	0.8	0.6	0.9	-1.3	-1.1	0.4	0.2	-0.0	1.3
Average weekly fortified wine intake	0.8	0.9	3.8	-0.1	-1.9	-0.3	0.7	0.7	-0.3	0.9	-1.1	0.5	-1.6	1.0	0.4
Maternal smoking around birth	0.8	1.2	3.6	-0.0	0.3	1.5	0.0	-1.6	0.2	-0.2	0.7	1.9	1.4	-1.5	-1.0
Fed-up feelings	0.9	1.6	7.9	0.5	0.1	2.8	1.3	1.2	0.4	-1.9	0.4	-0.6	0.9	-1.1	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	8.2	-0.2	-0.9	1.4	1.4	0.7	1.0	-1.7	-0.1	-1.2	0.3	0.3	2.9
Relative age voice broke	0.5	0.7	2.7	1.4	0.7	-1.1	0.1	-0.8	1.0	-0.4	0.8	-0.2	1.6	0.1	-0.5
Taking other prescription medications	0.8	1.3	4.7	1.5	1.0	2.0	0.3	-0.4	0.2	-0.6	0.9	0.9	2.2	-0.8	-0.5
Age when periods started (menarche)	0.8	1.9	8.6	0.1	0.1	2.9	1.8	0.7	2.1	-1.9	0.2	-0.1	1.4	0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.3	0.5	1.8	0.2	0.4	-0.2	-0.9	0.3	0.5	0.1	0.5	-1.5	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.8	-1.9	1.1	-1.6	-1.6	-1.4	-0.4	-1.0	1.6	0.7	1.3	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	4.8	0.8	-0.7	-0.7	-1.0	-0.9	0.6	-2.2	-0.7	-0.6	0.2	1.1	-0.4
Qualifications: CSEs or equivalent	0.7	0.9	2.8	1.2	0.7	1.2	1.4	0.4	0.1	-0.0	1.3	-0.0	1.7	-0.1	0.9
Serious illness, injury or assault to yourself	1.4	1.6	5.7	0.8	0.6	-0.2	-1.2	-0.7	-1.6	0.7	-1.0	-0.9	-0.8	-2.4	-2.3
High blood pressure	0.4	1.2	4.7	1.2	0.2	-0.8	-1.6	-1.4	0.1	-0.2	-0.7	-0.3	-0.2	-2.2	-1.6
Hayfever, allergic rhinitis or eczema	1.1	2.3	8.2	-2.0	1.3	-2.3	-1.0	-2.1	0.2	-0.6	0.7	-1.4	0.2	2.9	0.5
Multivitamins +/- minerals	0.4	0.5	1.7	-0.1	0.3	1.0	0.1	0.6	0.8	-0.4	0.9	-0.8	1.3	-0.4	0.7
Stomach or abdominal pain in last month	0.3	0.4	1.5	0.7	-0.7	1.2	0.1	0.4	0.0	-0.8	0.4	0.2	0.5	-0.5	1.0
Supplements: Glucosamine	0.2	0.3	0.9	0.4	-0.4	-0.7	0.2	-0.0	0.6	0.9	-0.1	0.3	0.2	-0.3	-0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	1.0	0.7	0.9	-0.2	-0.6	0.1	-1.0	0.2	0.5	1.3	-0.9	-0.8
Medication: Atenolol	0.7	0.9	5.5	-0.2	-0.6	-0.2	-1.0	-0.3	-2.3	0.4	-0.7	-1.5	-0.9	-0.1	-0.0
Medication: Levothyroxine sodium	1.4	2.5	6.1	1.6	1.0	2.3	1.2	-0.1	1.8	-1.0	-0.1	2.5	0.9	-1.5	-2.3
Sitting height	0.1	0.8	2.8	1.3	0.3	-0.1	0.5	-0.1	1.7	0.8	0.1	1.4	0.0	0.7	-1.3
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	0.7	0.7	0.9	0.3	0.6	0.8	0.1	0.7	1.4	1.0	-0.5	0.1
High blood pressure (mother)	0.7	1.0	2.9	-0.3	1.1	-0.2	0.1	-1.0	-1.2	0.1	1.7	1.7	0.8	-0.9	-1.2
Body mass index (BMI)	0.3	1.4	8.3	-0.5	0.2	-0.4	-0.0	-2.9	-0.7	1.4	-1.0	-0.2	-0.2	-1.4	-1.6
Impedance of leg (left)	1.1	5.2	14.0	3.3	-2.3	2.8	0.9	2.4	3.7	-3.2	-1.8	1.5	-0.0	-0.0	1.1
Leg predicted mass (left)	0.3	1.7	6.8	-1.3	1.3	-1.0	0.3	-2.2	-0.7	2.6	0.4	0.7	-0.2	0.6	-1.5
Trunk fat mass	0.2	1.1	6.4	0.4	0.1	0.3	0.4	-2.5	0.5	0.6	-0.9	1.2	0.1	-0.8	-1.6
Waist circumference	0.2	0.8	5.0	0.2	0.3	-0.4	0.0	-2.2	-0.5	1.2	-0.9	0.2	0.2	-0.2	-1.2
Number of incorrect matches in round	1.9	3.1	7.1	-1.5	-1.3	-0.4	-2.2	-1.6	-0.9	-2.7	0.9	-2.3	1.0	2.5	2.3
Past tobacco smoking	0.9	1.6	5.9	-1.5	-1.3	-1.5	-0.5	0.3	-0.4	2.0	-0.9	-1.1	-2.4	0.6	0.2
Alcohol usually taken with meals	0.6	1.0	4.4	0.1	0.8	-2.1	-0.9	0.9	-0.2	1.6	0.8	0.4	-0.4	-0.5	-1.1
Nervous feelings	1.8	3.4	16.4	-0.5	-1.4	2.2	0.9	1.3	0.6	-2.6	-0.8	-2.2	-0.1	1.5	4.0
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	9.3	0.1	-0.8	3.0	1.6	1.8	0.7	-0.4	-0.4	-0.6	0.0	-0.1	3.1
Hearing difficulty/problems with background noise	0.4	0.6	2.6	-1.3	-0.0	0.2	0.4	-1.4	0.3	-0.2	0.2	0.4	0.1	1.6	0.6
Hair/balding pattern: Pattern 2	1.1	1.4	3.6	1.3	0.9	1.9	0.2	1.6	-0.8	1.1	0.2	1.8	0.1	-1.7	0.2
Had menopause	3.0	3.7	13.9	-1.4	-3.0	-1.4	0.8	-2.0	-0.9	1.7	-2.8	-0.8	-3.7	-0.5	-0.3
Had other major operations	1.3	1.6	4.6	2.2	0.9	-0.2	-1.0	0.9	-0.2	2.0	0.4	0.2	0.3	-1.9	-2.0
Forced vital capacity (FVC)	0.4	1.4	4.1	0.7	1.4	1.4	1.2	1.3	-0.4	2.0	1.2	1.6	0.1	0.8	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.1	-0.9	2.0	-1.3	-0.8	-0.7	-0.5	0.4	2.0	1.4	1.6	-0.9	-1.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	3.2	0.8	0.0	1.6	0.3	1.4	-0.2	-0.9	0.0	-0.8	0.3	-1.8	0.6
Qualifications: None of the above	0.9	1.8	9.7	0.2	0.5	1.7	0.2	-2.0	0.8	-2.0	0.6	0.4	3.1	-0.3	0.1
Financial difficulties in last 2 years	0.7	0.9	4.1	-0.3	1.2	-0.3	-0.4	-1.7	-0.2	-0.9	0.6	-0.6	2.0	0.9	0.1
Mouth/teeth dental problems	1.5	2.3	9.0	-0.1	-1.1	-3.0	-2.0	-0.2	-0.5	1.2	-1.6	-1.4	-2.4	0.3	-0.9
Heart attack	0.7	0.9	2.9	-0.6	1.0	0.2	-0.4	-1.2	-0.2	-1.1	1.1	-1.7	1.4	0.4	0.1
Allergy	0.6	1.3	3.8	1.2	-1.8	1.2	0.6	1.9	-0.2	-0.1	-1.3	-0.3	-1.1	-1.5	-0.0
Pain all over the body in last month	0.2	0.2	1.0	1.0	-0.3	-0.5	-1.0	-0.3	-0.4	0.2	-0.5	0.2	0.1	0.0	-0.2
Diabetes (self-reported)	0.8	1.2	3.8	0.4	0.5	-2.0	-1.3	-1.3	-1.7	0.3	0.2	-1.6	1.0	0.5	0.1
Hayfever/allergic rhinitis (self-reported)	2.4	3.2	8.5	-1.6	1.6	-2.9	-1.9	-2.6	0.2	-1.5	0.9	-1.7	0.7	2.5	0.8
Medication: Ramipril	1.3	1.7	4.0	1.3	-1.6	0.5	0.4	1.4	1.3	0.4	-2.0	0.2	-1.8	-1.8	-1.1
Medication: Simvastatin	1.6	2.3	6.6	1.0	-1.0	-2.4	-1.6	1.0	-1.0	1.0	-1.7	-2.6	-2.1	0.2	0.3
Fluid intelligence score	0.5	1.0	5.7	-0.7	1.7	-2.4	-0.5	0.3	0.4	0.9	0.8	0.4	-0.4	0.4	-0.7
Illnesses of siblings	0.2	0.3	0.9	0.3	-0.9	-1.0	-0.6	0.1	0.1	-0.8	-0.1	-0.2	-0.3	0.1	-0.4
Neuroticism score	1.2	2.5	8.5	0.9	-0.5	2.9	1.0	2.1	0.8	-2.2	-0.7	-0.9	0.2	0.1	2.9
Weight	0.2	1.1	6.1	-0.5	0.7	-0.1	0.5	-2.5	-0.1	1.9	-0.5	0.8	-0.1	-0.0	-1.5
Impedance of arm (right)	0.5	2.3	6.7	0.8	0.0	1.6	1.3	2.6	1.3	-2.2	1.3	1.8	1.0	-0.3	1.6
Arm fat percentage (right)	0.3	1.0	5.9	0.0	0.1	-0.2	0.1	-2.4	-0.2	0.4	-0.8	0.4	0.0	-1.7	-1.4
Trunk fat-free mass	0.3	1.8	9.1	-1.4	1.4	-0.9	-0.0	-1.8	-0.8	3.0	0.5	0.5	-0.1	1.3	-1.2
Hip circumference	0.4	1.5	5.8	-0.1	0.2	0.0	1.0	-1.9	-0.2	2.4	-0.6	0.8	-0.7	-1.1	-2.3
Time employed in main current job	0.7	0.8	4.0	-1.1	-0.1	0.2	0.4	0.5	-0.6	-1.0	-0.1	-1.5	-0.5	0.4	2.0
Alcohol intake versus 10 years previously	1.8	2.7	10.5	1.6	-1.3	3.2	2.9	0.2	1.7	-0.2	-1.2	-0.4	0.1	-2.0	-0.4
Father’s age at death	0.9	1.3	3.0	-0.3	-1.5	0.6	1.7	-0.7	1.0	-0.2	-0.9	1.3	-1.2	1.7	1.1
Worrier / anxious feelings	1.6	3.0	8.3	1.5	-1.4	2.4	1.3	1.7	1.6	-2.9	-1.8	-1.9	-0.0	-1.3	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	8.9	0.5	0.9	1.8	1.0	0.2	0.5	-0.6	0.4	0.6	1.3	-3.0	0.3
Falls in the last year	1.0	1.4	4.4	-0.5	-2.1	-0.4	-0.2	-1.3	-0.1	-1.4	-1.5	-1.2	-1.2	1.0	1.5
Hair/balding pattern: Pattern 3	0.5	0.8	2.2	-0.9	-0.5	-0.8	-0.7	-1.4	0.0	0.6	0.6	-1.5	-0.3	1.2	-1.0
Number of live births	0.5	0.8	3.5	0.8	-0.3	-0.7	-1.9	-0.3	-1.0	-0.4	-0.2	-0.2	0.4	-1.4	-1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	6.5	0.6	1.8	1.6	1.1	1.5	-0.1	2.5	1.7	2.2	0.6	0.2	-0.8
Pulse rate	1.5	2.5	9.1	1.5	-2.0	0.3	0.5	0.7	2.0	-0.9	-3.0	-0.7	-2.2	1.2	1.6
Happiness	1.9	2.3	8.3	-0.5	-2.3	0.5	1.2	1.3	-0.0	-0.5	-1.3	-2.2	-1.5	0.6	2.9
Noisy workplace	1.5	1.8	7.7	1.0	-0.3	2.8	0.2	0.2	0.6	-2.6	0.3	-0.5	1.9	-1.2	0.4
Qualifications: A levels/AS levels or equivalent	0.9	1.9	6.8	-2.5	-0.8	-1.5	0.2	-0.6	-1.2	1.4	-0.4	-0.6	-2.6	1.7	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.3	-0.6	1.2	0.1	-0.1	0.1	0.2	0.1	1.0	-1.0	0.4	1.5	0.8
Mouth/teeth dental problems: Dentures	1.3	2.1	7.2	-1.2	0.8	0.8	1.2	-0.4	0.1	-0.8	2.3	-0.6	2.7	1.9	2.0
Asthma	0.5	1.0	3.3	0.2	1.1	-0.7	-1.6	-1.0	-0.1	0.2	1.1	0.3	1.8	-1.1	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.0	0.5	-0.3	-0.1	0.2	0.5	-0.7	1.4	0.2	0.1	-0.1	-0.8	-0.9
Medication: Cholesterol lowering	1.6	2.5	6.0	1.1	0.6	-2.5	-2.4	0.3	-1.1	1.8	-1.4	-1.7	-1.5	-0.9	-2.2
Depression (self-reported)	1.6	2.0	7.9	0.7	-1.0	2.8	1.6	0.1	1.8	-1.8	-0.8	1.2	1.3	0.2	1.2
Medication: Lansoprazole	1.4	1.6	7.4	-0.0	1.2	0.4	-0.8	-2.3	0.8	-2.7	0.2	-0.7	1.5	1.0	0.6
Prospective memory result	1.0	1.2	4.2	0.7	-0.6	1.3	2.1	1.4	-0.4	-1.0	-1.1	-1.2	0.0	0.3	1.3
Lung cancer (father)	0.8	0.9	5.6	1.2	0.8	0.1	1.0	2.4	0.8	0.1	-0.7	-0.3	-0.9	-0.6	0.5
Illnesses of mother	0.5	0.6	2.5	-0.4	-0.2	-0.8	-0.2	1.0	1.2	-1.6	-0.0	-0.5	0.3	0.7	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	6.6	1.2	2.0	1.9	1.6	2.3	0.4	2.6	1.2	2.3	0.3	0.5	-0.9
Pulse wave Arterial Stiffness index	0.5	0.6	3.1	0.5	-1.8	0.2	0.6	-0.1	0.8	0.1	-1.1	-1.0	-0.5	-0.3	0.2
Impedance of arm (left)	0.5	2.5	8.8	1.5	0.4	1.6	0.7	3.0	1.6	-2.0	1.7	2.2	1.2	-0.3	0.9
Arm fat mass (right)	0.3	1.1	5.9	0.1	0.3	-0.1	0.3	-2.4	0.0	1.2	-0.8	0.6	0.1	-1.2	-1.7
Trunk predicted mass	0.3	1.8	9.4	-1.4	1.4	-0.9	0.1	-1.7	-0.8	3.1	0.5	0.6	-0.1	1.2	-1.2
Standing height	0.2	2.2	7.6	0.4	1.3	0.8	1.2	0.8	1.5	1.8	1.3	2.7	0.3	2.8	-0.3
Length of working week for main job	1.0	1.2	4.8	-0.9	1.1	0.5	2.2	0.4	0.5	-1.7	0.7	0.3	1.1	-0.8	1.1
Exposure to tobacco smoke at home	1.6	1.8	5.8	-0.1	-1.8	2.4	1.9	-0.6	1.4	-1.8	-1.0	-0.4	-0.2	0.0	1.6
Breastfed as a baby	0.3	0.3	2.1	-0.2	-0.4	-0.7	-0.2	-0.1	-0.2	0.1	-0.6	-1.4	-0.8	-0.2	0.2
Tense / ‘highly strung’	1.5	2.5	7.2	0.8	-1.4	2.7	0.8	0.8	0.8	-2.7	-1.5	-2.0	-0.1	-1.6	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.5	8.6	2.6	0.2	2.9	0.4	2.5	0.9	0.0	0.2	1.6	1.5	-1.5	0.4
Hair/balding pattern: Pattern 4	0.4	1.0	5.4	0.0	-1.0	-1.0	-0.2	-0.5	0.0	-2.3	-1.6	-1.1	-0.5	0.4	0.7
Birth weight of first child	0.8	1.4	4.4	-1.1	-0.6	1.8	2.0	-0.5	0.6	0.3	-0.5	-0.0	-0.4	2.1	1.7
Peak expiratory flow (PEF)	1.6	3.8	13.9	-0.9	3.2	0.7	-1.7	-0.3	-1.9	1.5	3.7	1.6	2.6	-0.9	-0.9
Pulse wave reflection index	0.5	0.6	2.0	0.0	0.8	1.0	-0.5	0.5	0.6	0.6	0.8	1.4	0.9	-0.9	-0.4
Ever highly irritable/argumentative for 2 days	1.9	2.3	9.0	0.6	1.2	3.0	1.5	0.7	0.6	-1.5	1.4	0.6	2.6	-0.6	1.2
Loud music exposure frequency	0.6	0.6	1.7	0.9	-0.4	1.0	1.1	-0.1	1.3	-0.9	-1.1	-0.4	-0.3	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	8.0	-1.8	-1.3	-1.9	-1.1	-0.7	-1.4	2.1	-0.8	-0.8	-2.8	-0.2	-0.8
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.3	1.0	-0.3	1.0	-0.6	-0.0	0.7	-0.2	0.0	1.4	0.4	-1.8	-1.2
Blood clot in the leg (DVT)	0.5	0.6	2.0	-1.1	0.4	-0.8	-1.4	-0.6	-1.3	0.0	0.7	0.4	-0.1	0.7	0.4
Medication: Paracetamol	0.2	0.4	0.9	0.6	0.7	-0.4	-0.9	-0.2	-0.3	-0.6	0.7	-0.8	0.9	-0.5	0.1
Headache pain in last month	0.6	1.0	3.1	1.3	-0.3	0.5	1.1	1.8	1.7	-0.3	0.1	0.4	0.4	-0.4	1.4
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.6	-1.3	0.0	1.9	2.1	-0.2	0.5	-2.1	1.6	1.3	1.5	1.3	1.9
Glaucoma (self-reported)	0.6	0.7	2.2	1.1	0.3	-0.0	-0.0	-0.4	0.2	1.0	1.1	0.9	1.5	0.2	-1.2
Gout (self-reported)	1.1	1.5	4.2	0.5	-1.9	1.3	1.4	0.6	0.3	1.1	-1.6	1.0	-2.1	-1.0	-0.5
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	6.8	2.1	-0.7	2.6	1.7	0.5	2.0	-2.1	-1.4	1.9	-0.2	-1.3	-1.2
Medication: Amlodipine	1.0	1.4	5.1	1.0	0.4	-2.3	-0.9	-1.6	-1.0	1.8	-0.4	-0.5	0.0	0.3	-1.6
Medication: Ventolin 100micrograms inhaler	1.5	2.0	5.8	1.7	2.0	0.3	0.4	1.5	0.5	0.7	1.8	1.0	2.4	-1.7	-0.6
Birth weight	0.6	1.2	3.9	-0.8	-0.7	0.3	0.8	1.4	-0.1	2.0	-0.6	-0.3	-1.8	1.1	1.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	7.5	-0.7	0.2	2.0	1.0	-1.5	-0.6	-2.7	0.7	-0.2	1.3	0.4	1.0
High blood pressure (siblings)	0.4	0.5	2.0	-0.7	0.5	1.4	1.2	-0.5	-0.0	0.6	0.2	0.7	-0.1	-0.9	-0.4
Forced vital capacity (FVC), Best measure	0.5	1.9	4.2	1.1	1.4	1.8	1.5	2.1	0.1	2.0	0.7	1.8	-0.1	0.6	-1.1
Body fat percentage	0.3	1.3	4.9	1.2	-0.5	0.3	0.2	-2.2	0.8	-0.2	-1.6	0.7	-0.1	-1.5	-1.6
Leg fat percentage (right)	0.6	2.0	6.5	1.6	-1.1	-0.1	-0.0	-2.5	1.4	-0.1	-2.3	0.7	-0.3	-1.5	-2.0
Arm fat-free mass (right)	0.3	1.5	7.3	-0.4	0.6	-0.7	0.0	-2.0	-0.1	2.7	-0.7	0.8	-0.9	0.7	-1.7
Exposure to tobacco smoke outside home	1.1	1.4	4.5	-0.2	0.8	2.1	-0.4	-0.3	0.3	-1.6	0.9	0.4	2.0	0.8	1.9
Comparative body size at age 10	1.1	3.0	12.4	-1.7	-0.3	-3.5	-0.8	-1.3	-2.0	2.9	-0.4	-1.3	-2.0	-0.2	0.2
Number of full brothers	1.0	1.3	7.3	1.5	-0.3	-0.7	-0.1	2.7	0.2	1.2	-0.6	-1.2	-0.3	-1.3	-0.1
Worry too long after embarrassment	0.3	0.5	1.9	-0.4	-0.6	0.7	0.8	0.4	-0.3	-1.4	-0.4	-0.2	-0.7	-0.5	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	7.2	0.5	-0.1	1.8	1.0	1.1	0.5	-0.4	0.3	0.5	1.4	0.6	2.7
Wheeze or whistling in the chest in last year	0.6	1.0	3.9	-0.0	0.6	-0.3	-0.8	-2.0	-0.2	-1.4	0.5	-0.8	1.8	-0.7	0.9
Number of children fathered	0.4	0.5	1.5	-0.1	1.2	-0.9	-0.7	-0.3	0.2	0.2	0.9	-0.7	0.9	0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.8	-0.4	-0.2	-0.8	-0.3	-0.5	0.2	0.2	0.6	0.3	-0.0	0.2
Age at first live birth	2.6	4.6	16.1	-0.6	-1.1	-4.0	-1.8	-0.8	0.3	2.2	-2.3	-3.1	-3.2	1.8	-0.8
Pulse wave peak to peak time	0.7	0.8	4.5	-0.4	2.1	-0.2	-0.4	0.1	-0.4	-0.1	1.4	1.3	0.8	0.4	-0.3
Health satisfaction	0.2	0.2	0.6	0.5	-0.8	0.6	0.4	0.1	0.4	-0.5	-0.6	-0.4	-0.1	-0.7	-0.1
Shortness of breath walking on level ground	0.8	1.0	3.2	0.5	-0.4	-1.7	-0.5	-1.4	0.1	-0.1	-1.8	-1.3	-0.5	-0.1	-0.9
Qualifications: College or University degree	1.5	4.8	16.0	-3.4	1.4	-4.0	-0.4	0.4	-2.3	2.9	1.7	-1.1	-1.8	2.4	1.1
Eye problems/disorders: None of the above	0.7	0.8	2.6	-1.4	0.6	-1.2	-0.7	0.5	-0.3	-0.6	-0.3	-1.0	-1.6	0.5	0.6
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.0	-0.7	1.4	1.7	0.9	-1.5	-0.1	0.2	-0.1	1.7	-0.1	0.6	0.1
Emphysema/chronic bronchitis	3.1	3.5	15.6	0.6	1.8	1.6	1.2	0.3	0.7	-0.8	2.8	2.8	4.0	0.6	1.4
Medication for pain relief, constipation, heartburn	0.8	1.4	6.2	-2.5	-0.4	-1.0	0.8	-0.5	1.0	0.2	-1.1	0.5	-2.1	1.1	0.9
Neck or shoulder pain in last month	1.5	2.1	8.4	1.3	2.2	-1.3	-1.2	0.1	-0.7	0.4	2.9	1.3	2.2	-0.7	-0.3
Medication: Blood pressure	1.2	2.1	5.5	0.8	-0.9	-1.9	-1.9	-1.0	-0.2	1.0	-2.3	-2.0	-1.7	-1.0	-1.2
Angina (self-reported)	0.4	0.5	2.1	1.4	0.1	1.0	-0.4	0.6	-0.1	-0.0	0.1	-0.4	1.0	-1.0	-0.4
Migraine (self-reported)	0.7	0.8	3.2	0.2	-0.3	1.8	1.0	1.5	0.3	0.0	0.1	-0.5	0.3	0.1	1.7
Medication: Ibuprofen	0.3	0.3	0.8	0.7	-0.0	0.4	0.5	0.1	-0.4	0.4	0.6	0.3	0.6	-0.9	-0.9
Medication: Allopurinol	0.4	0.6	1.8	0.0	-1.0	0.1	0.9	0.3	0.4	0.6	-1.0	1.2	-1.3	0.1	-0.5
Medication: Omeprazole	1.7	2.1	5.4	2.0	1.7	1.0	-0.3	1.0	0.7	1.6	1.0	1.4	2.0	-0.8	-2.3
Medication: Seretide 50 evohaler	0.8	0.9	1.8	-1.2	0.5	-0.1	-0.9	-1.3	-0.4	1.0	1.3	1.0	1.0	-0.7	-1.0
Mean time to correctly identify matches	1.7	3.2	14.3	0.2	-1.9	3.8	2.9	0.9	0.6	-0.5	-0.9	-0.7	-0.6	-3.0	0.5
Heart disease (mother)	0.5	0.6	1.9	0.4	0.7	1.4	1.0	0.3	-0.3	-0.1	0.7	-0.3	1.0	1.0	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.8	1.1	1.3	-0.5	-0.6	0.6	-1.4	1.3	1.2	0.3	0.9	-0.1	-0.1
Whole body fat mass	0.3	1.2	5.8	0.6	-0.1	-0.0	0.3	-2.4	0.5	0.8	-1.3	0.8	-0.2	-1.1	-1.9
Leg fat mass (right)	0.4	1.6	7.2	0.9	-0.3	-0.2	0.2	-2.7	0.9	1.0	-1.7	0.8	-0.3	-1.2	-2.1
Arm predicted mass (right)	0.3	1.3	6.6	-0.1	0.7	-0.6	0.1	-1.7	0.2	2.6	-0.7	0.6	-0.5	0.6	-1.8
Pulse rate, automated reading	0.7	2.2	6.6	2.6	-1.9	1.5	0.8	-0.2	2.4	-0.8	-2.1	1.2	-0.4	-0.8	0.1
Alcohol intake frequency.	1.2	2.9	9.9	1.5	-3.1	1.8	1.7	-0.0	1.3	-2.3	-1.7	-0.2	0.2	-2.5	-0.2
Comparative height size at age 10	0.2	0.9	2.9	-0.9	1.5	1.1	1.3	-0.1	0.3	0.6	1.7	0.8	0.8	0.4	0.0
Number of full sisters	1.3	1.5	4.7	2.2	0.6	1.2	0.1	1.0	1.3	-0.6	-0.1	2.0	0.6	-1.8	-1.2
Suffer from ‘nerves’	1.5	2.4	10.9	0.7	-1.4	1.8	0.5	1.7	0.7	-2.3	-1.0	-1.3	0.1	0.9	3.3
Overall health rating	1.0	2.1	8.1	1.5	-0.8	2.1	1.0	-0.5	1.0	-2.8	-0.6	-0.6	1.9	-0.0	1.9
Chest pain or discomfort	1.5	2.2	8.7	-0.0	1.0	0.7	-1.4	-0.6	-1.6	-1.4	2.9	-0.1	2.9	-0.9	0.6
Had major operations	0.1	0.2	0.4	0.3	0.2	0.3	-0.0	0.6	-0.6	0.5	0.2	-0.1	0.4	0.5	0.7
Age at last live birth	1.7	2.5	8.5	-1.4	-1.5	-2.9	-0.8	-0.5	-0.2	0.8	-1.1	-2.5	-1.7	2.0	1.0
Family relationship satisfaction	1.0	1.2	5.1	-1.1	-1.9	0.4	0.7	-0.1	-0.8	1.2	-0.5	-0.9	-0.9	0.1	2.3
Leg pain on walking	0.5	0.6	3.0	0.9	0.5	1.7	0.2	-0.3	-0.2	-1.2	-0.0	0.6	0.2	-0.4	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.1	0.3	1.2	1.2	0.9	0.7	-0.1	0.6	1.3	1.4	1.5	-0.3	0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.8	0.6	0.4	0.5	0.0	-1.0	1.1	-0.3	0.1	0.6	1.4	-1.1	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.5	-0.5	-1.2	0.4	0.8	-0.6	0.7	-0.6	-0.4	0.3	-0.3	0.1	0.9
Medication: Aspirin	0.7	0.9	4.7	1.7	-0.6	2.2	0.5	0.2	-0.4	-1.3	0.1	0.8	0.7	-0.5	0.1
Supplements: Vitamin C	1.7	2.1	5.7	2.1	-1.1	1.9	1.4	-0.1	2.4	-1.1	-1.3	1.8	0.6	-1.1	-0.3
Knee pain experienced in last month	0.2	0.4	1.9	-0.1	0.7	-0.8	-0.1	-0.6	-1.4	0.4	0.6	-0.3	0.4	-0.3	0.5
Hypertension (Self-reported)	0.4	1.0	3.1	1.0	0.2	-0.5	-1.3	-1.7	0.2	-0.5	-0.5	-0.3	0.1	-1.8	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	4.5	2.0	0.9	1.5	0.5	-0.5	1.5	0.0	0.2	0.9	1.8	-1.8	-2.1
Illnesses of father: Heart disease	0.4	0.6	2.3	0.9	-0.2	-1.0	-1.3	1.0	-0.2	1.5	0.4	0.1	0.0	0.2	-0.0
Illnesses of siblings: Diabetes	1.2	1.5	5.5	1.3	-1.6	0.2	1.3	0.8	1.3	-0.3	-2.3	-1.7	-0.9	-0.7	0.4
Smoking status: Previous	0.8	1.2	4.6	1.5	1.7	0.8	0.0	0.1	0.1	-0.7	1.0	0.9	2.1	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	7.0	-0.2	1.0	0.2	0.9	0.9	1.6	0.1	0.7	0.9	0.7	2.7	1.4
Whole body fat-free mass	0.3	1.7	8.7	-1.3	1.3	-0.8	0.1	-2.0	-0.8	3.0	0.2	0.5	-0.3	1.0	-1.4
Leg fat-free mass (right)	0.3	1.6	6.9	-1.3	1.4	-0.8	0.4	-2.1	-1.0	2.6	0.4	0.4	-0.3	0.4	-1.4
Arm fat percentage (left)	0.3	1.0	4.9	0.2	0.1	-0.3	0.1	-2.2	-0.1	0.7	-0.9	0.4	-0.2	-1.7	-1.7
Average weekly red wine intake	0.8	1.2	5.1	-0.2	-0.7	-2.3	-0.8	-0.7	-1.0	1.9	-0.3	0.6	-1.3	0.7	-0.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	3.0	0.7	-0.9	0.6	1.3	0.6	0.0	-1.1	-1.1	-1.7	-0.1	-0.6	0.3
Mood swings	1.9	3.5	8.7	2.2	-1.2	2.2	1.9	3.0	2.0	-2.0	-1.7	-0.4	-0.4	0.3	2.8
Loneliness, isolation	1.0	1.4	4.4	-2.1	-0.1	1.9	0.9	-0.2	-0.5	-0.4	-0.1	-1.4	-0.7	0.5	2.1
Long-standing illness, disability or infirmity	0.3	0.5	1.6	1.3	0.3	0.8	0.3	0.7	-0.6	-0.4	-0.1	-1.1	0.8	-0.9	0.4
Ever had bowel cancer screening	0.6	0.6	2.0	-0.2	-0.0	0.9	-0.2	-0.6	-1.2	-1.4	0.7	-0.4	1.4	-0.2	0.5
Diabetes diagnosed by doctor	1.0	1.6	6.2	0.3	-0.1	-2.5	-1.2	-2.0	-1.6	0.5	-0.2	-1.6	0.8	1.4	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	2.7	-0.1	1.3	0.7	1.2	1.2	0.9	-0.2	0.3	1.7	1.4	-0.1	0.6
Friendships satisfaction	1.4	1.7	6.6	-1.1	-2.3	0.7	0.7	0.6	-0.2	-1.1	-0.5	-1.6	-1.3	0.9	2.6
Qualifications: nursing, teaching	1.2	1.9	12.0	-1.3	-1.3	-1.7	-0.2	0.0	-0.4	0.7	-1.5	-0.0	-3.5	0.4	-1.3
Commuting to job workplace: Walk	0.7	0.7	2.0	-1.1	-0.1	-1.4	0.5	-0.6	-0.1	0.2	-0.7	-0.7	-1.1	1.2	1.0
Eye problems/disorders: Cataract	0.8	1.0	3.6	1.6	-0.9	1.5	1.9	0.4	0.4	0.9	-0.8	0.3	0.3	-0.6	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.7	1.1	0.7	1.1	-0.0	1.0	0.6	0.2	0.4	1.3	1.0	-0.3	0.4
Medication for cholesterol	1.1	1.6	5.8	0.0	-0.6	-1.2	0.4	0.6	2.2	0.7	-0.7	2.3	-0.7	2.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	5.6	0.7	2.4	0.9	0.8	0.2	-0.0	-0.7	1.4	-0.1	2.3	0.7	0.3
Back pain experienced in last month	1.4	2.0	9.7	1.4	1.4	0.3	-0.9	-0.4	-0.8	-1.0	2.3	1.3	3.1	-0.6	-0.3
Mineral and other dietary supplements	0.3	0.4	2.2	-0.1	1.5	-0.1	-0.3	-0.6	-0.9	0.1	1.0	0.5	-0.1	0.3	-0.0
Breast cancer (self-reported)	1.5	1.8	7.8	0.4	0.1	-1.8	-2.4	0.5	0.8	-0.2	-1.4	-2.8	-1.2	-0.3	-0.7
Asthma (self-reported)	0.6	1.1	3.8	0.1	1.1	-0.8	-1.7	-1.1	-0.1	0.1	1.3	0.3	1.9	-1.2	-0.7
Osteoporosis (self-reported)	0.8	1.0	4.5	1.2	-0.8	-0.5	-0.0	0.5	0.0	2.1	-1.0	0.8	-1.4	-0.7	-1.0
Osteoarthritis (self-reported)	0.5	0.6	1.5	0.6	0.6	-1.2	-0.9	-0.7	-1.1	0.9	0.0	-0.8	-0.1	0.7	-1.0
Medication: Aspirin	0.7	1.0	5.8	1.3	-0.1	2.4	0.6	-0.1	-0.5	-1.2	0.6	0.6	1.2	0.1	0.3
Medication: Gliclazide	1.8	2.1	10.6	0.3	-3.3	0.4	1.0	-2.6	-0.1	-0.6	-2.0	0.9	-1.0	0.0	-0.6
Illnesses of father: None of the above (group 1)	0.7	0.8	3.6	-0.3	1.2	0.1	-0.5	-0.6	-1.2	-0.2	0.5	0.4	0.3	-1.9	-1.4
Smoking status: Current	0.7	1.1	4.2	1.6	-0.2	2.0	0.7	0.6	0.7	-1.4	-1.0	0.1	0.3	0.1	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	6.1	0.3	1.7	1.7	0.1	1.2	-1.4	2.5	1.6	1.5	0.4	-0.9	-1.1
Whole body water mass	0.3	1.7	8.0	-1.3	1.4	-0.8	0.1	-2.1	-0.8	2.8	0.3	0.5	-0.2	1.0	-1.4
Leg predicted mass (right)	0.3	1.5	6.3	-1.2	1.5	-0.6	0.5	-2.1	-0.9	2.5	0.4	0.4	-0.2	0.4	-1.3
Arm fat mass (left)	0.2	1.0	5.6	-0.1	0.3	-0.4	0.1	-2.4	-0.2	1.5	-0.9	0.4	-0.2	-0.9	-1.5
Number of self-reported non-cancer illnesses	1.0	1.8	5.3	0.8	0.9	1.9	-0.4	-2.1	0.4	-1.8	0.7	1.2	2.3	-0.8	-0.5
Average weekly champagne plus white wine intake	0.8	1.1	4.7	1.5	-0.9	-0.3	0.9	2.2	0.1	0.3	-0.6	0.4	-1.4	-1.1	-1.3
Miserableness	0.9	1.5	4.9	0.9	0.3	2.2	0.8	1.9	1.1	-2.0	0.1	0.9	0.9	-0.3	1.1
Guilty feelings	0.8	1.2	4.2	0.7	-0.5	2.1	-0.1	1.8	0.2	-0.1	-1.0	0.6	-0.3	-1.9	0.7
Wears glasses or contact lenses	1.2	1.3	3.6	-0.6	1.6	0.0	-0.0	-0.8	-1.9	0.4	1.8	1.6	1.1	-0.6	-1.2
Ever taken oral contraceptive pill	1.4	1.6	4.7	0.8	-1.3	1.6	2.2	-0.9	1.3	-1.7	-1.7	0.6	-0.2	-1.0	0.4
Hearing aid user	0.4	0.5	1.2	-0.5	1.1	-0.6	-0.5	-0.5	0.5	0.8	0.7	-0.5	0.9	0.4	-0.8
Mother’s age at death	1.7	2.1	7.5	-1.2	0.9	-1.7	-1.9	0.2	-2.7	2.3	0.5	-1.6	-0.6	0.1	-0.4
Financial situation satisfaction	0.3	0.4	2.8	-0.0	-0.5	0.4	0.5	-0.3	-0.2	-0.4	-0.8	-1.7	-0.0	-0.5	0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.5	-0.1	-1.0	-0.5	-0.5	0.6	-0.5	-0.1	-1.0	-0.7	-1.6	-1.5	-0.2
Commuting to job workplace: Public transport	0.8	0.9	2.9	-0.6	-1.1	0.4	1.3	0.0	0.3	-1.3	0.3	0.8	0.1	1.7	1.4
Eye problems/disorders: Glaucoma	0.4	0.4	1.4	0.7	-0.4	0.1	0.4	-0.7	0.5	0.2	0.5	1.1	1.2	0.6	-0.7
Medication: Blood pressure	0.6	1.1	2.9	0.3	0.8	1.1	0.7	-0.9	-0.8	-1.6	0.8	-1.7	1.0	-1.4	-0.5
Pain type(s) experienced in last month: Hip pain	0.9	1.1	5.1	0.6	0.9	-0.6	0.0	-0.4	-1.7	0.9	0.4	-2.3	1.4	0.9	0.5
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.8	-0.8	-0.9	-0.1	0.1	-0.8	0.3	-0.3	-0.3	-0.2	0.0	-0.1	-0.2
High cholesterol (Self-reported)	1.0	1.9	6.5	0.0	-0.2	-2.0	-2.5	0.1	-1.3	1.1	-1.3	-1.4	-1.6	-1.5	-0.7
Medication: Bendroflumethiazide	0.2	0.3	1.6	1.3	-0.3	-0.4	0.4	0.5	0.7	-0.4	-0.7	-0.2	-0.1	-0.0	-0.3
Medication: Paracetamol	0.4	0.6	2.0	1.4	0.5	0.1	-0.2	-0.1	0.4	-1.4	0.6	0.5	0.9	-0.8	-0.3
Medication: Lisinopril	0.3	0.4	1.3	0.4	-0.5	1.0	0.7	-0.7	0.3	-1.2	-0.2	-0.8	0.3	0.0	0.2
Medication: Atorvastatin	0.7	0.9	4.1	1.2	0.4	1.1	-0.5	0.8	0.3	0.6	-0.4	-0.3	-0.2	-2.0	-1.3
Illnesses of father: High blood pressure	0.7	0.8	4.3	-1.1	-0.3	-0.4	0.3	0.1	-0.1	-0.4	0.6	0.5	0.5	2.1	1.7
Alcohol drinker status: Never	1.8	2.2	5.9	-1.7	1.5	-2.4	-1.0	-1.0	-2.4	0.8	1.8	0.6	0.6	-0.6	-1.7
Ever smoked	0.9	1.6	5.2	1.6	0.4	1.8	1.1	0.1	1.2	-2.3	0.4	0.9	2.1	-0.4	0.3
Basal metabolic rate	0.3	1.5	6.9	-1.1	1.2	-0.7	0.2	-2.1	-0.6	2.6	0.2	0.6	-0.1	0.8	-1.3
Leg fat percentage (left)	0.6	2.0	8.8	1.3	-1.0	0.2	0.1	-3.0	1.1	-0.3	-2.4	0.3	-0.4	-1.4	-1.7
Arm fat-free mass (left)	0.2	1.1	5.4	-0.7	0.8	-0.1	0.3	-2.1	-0.4	2.3	-0.5	0.5	-0.3	0.5	-1.2
Number of operations (self-reported)	1.4	2.0	6.8	2.6	1.6	0.1	-0.4	1.5	-0.4	1.5	1.0	-0.0	1.4	-1.8	-2.0
Average weekly beer plus cider intake	0.4	0.6	3.0	-0.0	0.3	-0.5	-1.3	-1.7	0.6	-0.4	-0.1	0.8	0.1	-0.7	-0.6
Irritability	0.6	1.0	2.5	1.2	-1.1	1.2	0.6	0.2	0.3	-1.6	-1.5	-0.5	-0.6	-0.3	1.4
Risk taking	0.9	1.3	3.6	-0.1	-1.3	0.4	1.3	1.7	0.4	0.4	-1.0	0.8	-1.9	-0.2	1.9
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.2	0.1	0.4	-0.9	-0.3	1.5	0.4	0.0	1.1	0.9	0.3	1.3	0.7
Fractured/broken bones in last 5 years	1.2	1.5	4.5	0.3	-1.0	1.2	0.4	0.2	-0.6	2.1	-0.8	1.8	-1.0	-1.5	-1.9
Age started oral contraceptive pill	3.5	4.4	20.7	0.3	-3.6	-1.5	0.0	-0.0	0.5	0.6	-3.5	-1.5	-4.6	-0.3	-1.5
Diastolic blood pressure, automated reading	0.4	1.2	3.4	0.0	0.2	-1.1	-1.8	-1.3	-0.3	1.0	-0.8	1.6	-1.5	0.1	-1.0
Ever depressed for a whole week	1.7	2.0	8.8	3.0	-1.9	1.5	0.2	1.5	0.4	-1.4	-1.3	-1.3	-0.6	-0.9	0.8
Unable to work because of sickness or disability	1.3	1.7	5.6	1.2	-1.2	2.4	1.7	-0.6	1.2	-1.3	-1.8	-0.3	-0.1	0.1	1.4
Commuting to job workplace: Cycle	0.9	1.1	3.5	-1.7	-0.5	0.3	0.7	1.9	0.2	-0.2	-0.2	-0.2	-1.6	1.2	1.5
Myopia	0.4	0.6	1.9	-0.7	-0.3	0.1	1.1	0.8	0.6	1.0	-0.5	0.8	-1.4	-0.5	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.0	-1.2	-0.6	-0.0	1.4	1.3	0.3	0.3	0.1	0.2	-0.4	2.0	1.5
Cholesterol lowering medication	0.8	1.2	4.2	0.7	-0.6	-0.9	-1.4	-0.1	-1.1	0.1	-0.8	-1.4	-1.0	-2.1	-1.5
Medication: Omeprazole (e.g. Zanprol)	1.8	2.1	4.9	1.9	2.0	1.0	-0.4	1.2	0.2	0.8	1.4	1.6	2.2	-0.6	-2.2
Pain experienced in last month	0.6	1.0	4.4	-1.8	-0.4	0.1	-0.1	-0.2	0.3	0.7	-0.9	-1.4	-2.1	0.3	-0.9
Supplements: Calcium	1.0	1.1	4.8	1.5	0.1	0.0	0.7	0.7	0.9	2.2	-0.7	1.2	-0.6	-0.7	-1.2
Basal cell carcinoma (self-reported)	1.1	1.3	5.8	-0.9	0.5	-2.4	-1.7	-0.2	-1.8	0.8	-0.2	-0.5	-1.0	0.2	-0.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	4.4	-0.8	0.8	-0.2	-0.6	-1.5	-0.2	-1.3	1.0	-2.1	1.4	0.6	0.3
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.8	-1.1	0.4	-0.8	-1.7	-0.6	-1.3	0.0	0.6	0.0	-0.0	0.6	0.4
Heart disease (siblings)	1.3	1.6	6.5	0.4	2.5	-0.4	-1.7	1.0	0.2	0.9	1.8	0.3	1.9	0.5	0.4
Alcohol drinker status: Previous	2.3	2.6	6.9	0.2	-2.6	1.1	1.9	-0.5	0.7	-2.1	-2.4	-0.5	-1.2	1.0	2.5
Pack years of smoking	0.5	0.8	3.9	1.0	-1.1	0.0	0.5	-0.4	0.5	-0.7	-1.4	-2.0	-0.0	0.3	0.5
Impedance of whole body	0.9	4.7	10.6	3.0	-1.2	2.5	1.1	3.1	3.2	-3.2	-0.1	2.3	0.8	0.0	1.3
Leg fat mass (left)	0.4	1.5	7.8	0.7	-0.3	-0.0	0.2	-2.8	0.7	0.7	-1.8	0.5	-0.2	-1.0	-1.9
Arm predicted mass (left)	0.2	1.1	5.0	-0.6	0.6	-0.2	0.5	-2.1	-0.1	2.2	-0.6	0.6	-0.3	0.8	-1.1