TWAS hub - PREX2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1430	0.0490	2.3e-03	0.104	NA	0.101	NA	0.107	2.4e-06	NA	3.5e-06	NA	1.7e-06
2	GTEx	Artery Tibial	0.1950	0.0420	3.1e-07	0.144	NA	0.145	NA	0.168	2.4e-11	NA	1.8e-11	NA	4.0e-13
3	GTEx	Brain Cerebellum	0.3480	0.0990	2.8e-03	0.006	NA	0.007	NA	0.004	2.0e-01	NA	1.9e-01	NA	2.4e-01
4	GTEx	Brain Cortex	0.3940	0.1130	4.1e-03	0.072	NA	0.055	NA	0.095	4.9e-03	NA	1.3e-02	NA	1.4e-03
5	GTEx	Nerve Tibial	0.1272	0.0439	2.8e-03	-0.003	NA	-0.003	NA	-0.002	7.2e-01	NA	5.9e-01	NA	4.4e-01
6	ROSMAP	Brain Pre-frontal Cortex	0.0876	0.0331	1.9e-03	0.058	0.018	0.018	0.032	0.043	5.4e-08	0.0018	2.0e-03	4.3e-05	2.8e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Medication for hormone replacement therapy	4.2	4.7	11.2	1.6	1.6	0.7	2.5	2.2	3.3
Age when periods started (menarche)	3.9	9.4	18.2	2.9	3.2	2.4	2.9	2.3	4.3
Average weekly spirits intake	3.8	4.7	6.5	2.4	2.3	-2.1	-1.4	2.1	-2.5
Handedness (chirality/laterality): Left-handed	3.7	4.5	7.3	2.4	2.5	1.5	1.0	2.7	2.1
Multivitamins +/- minerals	3.4	4.3	9.7	2.6	2.6	-0.1	1.7	3.1	0.0
Blood White Count	3.2	23.9	49.7	6.7	6.6	0.2	-0.3	7.0	2.2
Forced expiratory volume in 1-second (FEV1), predicted	3.2	6.7	13.2	-3.6	-3.6	-1.1	-1.6	-3.1	-0.5
Financial difficulties in last 2 years	2.8	3.8	7.7	2.6	2.8	0.5	0.9	2.5	1.0
Loud music exposure frequency	2.8	3.1	5.9	-1.9	-1.8	-0.4	-1.9	-2.4	-1.3
Nervous feelings	2.6	4.8	9.3	-2.6	-2.7	-1.7	-1.6	-3.1	-0.7
Qualifications: CSEs or equivalent	2.5	3.3	7.8	-2.6	-2.8	-1.0	-0.1	-2.0	0.6
Serious illness, injury or assault of a close relative in last 2 years	2.5	2.9	5.7	-2.4	-2.0	0.9	1.6	-2.1	0.4
Breastfed as a baby	2.4	2.9	5.9	-2.3	-2.4	-1.2	-0.9	-2.0	-0.3
Vitamin and mineral supplements	2.2	2.9	5.1	-2.1	-2.1	0.2	-1.6	-2.3	-1.0
Number of full brothers	2.0	2.5	4.3	1.2	1.2	1.3	2.1	1.5	2.0
Friendships satisfaction	2.0	2.5	4.1	-1.1	-1.2	-2.0	-2.0	-1.7	-1.1
Relative age voice broke	1.8	2.8	5.0	1.8	2.0	0.0	1.1	1.8	2.2
Time employed in main current job	1.7	2.0	5.0	-1.7	-1.4	0.6	2.2	-0.9	1.1
Pulse rate	1.7	2.8	5.2	-1.3	-1.4	-2.0	-1.6	-1.2	-2.3
Medication: Seretide 50 evohaler	1.7	1.9	5.7	0.2	0.1	0.8	2.4	-0.4	2.2
Medication: Ramipril	1.6	2.0	4.3	-1.9	-1.9	-0.2	0.5	-2.1	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.9	-2.0	-1.9	0.8	-0.5	-1.6	0.5
Pain experienced in last month	1.6	2.7	8.7	0.3	0.4	1.7	2.9	1.0	1.8
Alcohol drinker status: Previous	1.6	1.8	3.0	-1.4	-1.3	1.7	0.9	-0.7	1.7
Blood clot in the leg (DVT)	1.5	1.9	7.3	-0.1	-0.3	-2.7	-1.2	-0.3	-1.7
Emphysema/chronic bronchitis	1.5	1.7	3.2	1.0	1.1	1.1	1.7	0.8	1.8
Commuting to job workplace: Public transport	1.5	1.7	3.7	1.5	1.3	-1.9	-1.2	1.2	0.2
Bipolar Disorder (2018)	1.4	2.2	9.1	0.5	0.6	1.0	1.2	1.0	3.0
Bipolar Disorder (2011)	1.4	1.4	4.4	-0.8	-0.5	0.2	1.7	-0.0	2.1
Body Mass Index (BMI) (2010)	1.4	2.0	5.5	0.8	0.9	0.0	2.4	2.1	-0.5
Schizophrenia (2014)	1.4	3.2	6.4	2.1	2.5	0.3	1.1	1.8	1.8
Other serious medical condition/disability diagnosed by doctor	1.4	1.9	4.8	2.1	2.2	-0.2	-0.1	1.3	0.4
Glaucoma (self-reported)	1.4	1.6	2.9	1.5	1.5	-0.6	0.7	1.1	1.7
Worry too long after embarrassment	1.4	2.3	9.6	-0.1	-0.2	-0.1	2.1	-0.0	3.1
Breast cancer (self-reported)	1.4	1.7	7.0	0.1	0.2	0.9	1.5	-0.0	2.6
Illnesses of father: None of the above (group 1)	1.4	1.8	3.3	1.5	1.8	1.8	-0.5	1.0	-0.7
Medication: Lisinopril	1.4	1.7	4.1	-1.9	-2.0	-0.7	-0.8	-0.6	-1.1
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	7.5	-0.0	-0.2	-2.7	-1.1	-0.3	-1.4
Bipolar Disorder or Schizophrenia	1.3	3.2	11.3	1.0	1.4	0.8	1.7	1.1	3.4
Fasting Glucose	1.3	1.5	4.3	-1.1	-1.0	1.4	0.0	-0.7	-2.1
Hand grip strength (left)	1.3	3.4	7.0	2.4	2.3	-0.4	1.0	2.7	1.1
Ever used hormone-replacement therapy (HRT)	1.3	1.7	6.6	0.6	0.5	-0.0	2.6	0.5	1.7
Frequency of tenseness / restlessness in last 2 weeks	1.3	1.9	3.9	1.5	1.2	-0.8	1.0	2.0	1.5
Prospective memory result	1.3	1.6	5.1	1.1	1.2	2.3	1.2	0.4	0.5
Exposure to tobacco smoke outside home	1.3	1.7	3.4	1.8	1.9	-0.0	-0.4	1.6	1.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.4	-1.2	-0.7	2.1	1.2	-1.0	0.6
Medication: Bendroflumethiazide	1.3	2.0	3.0	-1.5	-1.6	-1.0	-1.6	-1.7	-0.9
Systolic Blood Pressure	1.2	5.8	14.7	-3.2	-2.9	-1.0	-0.0	-3.8	0.8
Alcohol intake versus 10 years previously	1.2	1.8	4.2	-2.1	-1.9	0.3	-0.3	-1.6	-0.3
Happiness	1.2	1.4	2.6	-0.7	-0.6	-1.6	-1.4	-1.2	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.8	-1.0	-0.8	-1.1	1.7	-0.5	1.7
Neck or shoulder pain in last month	1.2	1.7	3.5	-0.5	-0.7	-1.2	-1.9	-1.3	-1.6
Migraine (self-reported)	1.2	1.5	3.3	-1.3	-1.1	0.8	1.2	-1.0	1.8
Medication: Omeprazole	1.2	1.4	4.0	0.7	0.6	-1.9	-0.1	0.2	-2.0
Comparative height size at age 10	1.2	6.6	11.4	-3.0	-3.4	-3.1	-0.8	-2.9	-0.8
Illnesses of siblings: Diabetes	1.2	1.4	3.4	-1.0	-1.0	-0.9	-1.4	-0.6	-1.8
Financial situation satisfaction	1.2	1.5	2.6	1.4	1.6	-0.8	-1.1	0.8	-1.5
Lupus	1.1	1.6	4.5	1.2	1.0	-0.7	-2.1	0.4	-1.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.1	-1.2	-1.0	1.8	0.8	-1.2	0.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.1	1.5	1.4	-0.4	-0.2	1.8	-1.1
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.4	-0.0	0.3	1.8	1.4	0.3	1.6
Alcohol intake frequency.	1.1	2.6	5.8	-2.4	-2.2	0.6	-0.0	-1.5	-1.4
Medication: Aspirin	1.1	1.5	2.9	1.7	1.7	-1.2	-0.1	1.2	-0.7
Medication: Aspirin	1.1	1.5	2.2	1.5	1.5	-1.2	-0.5	1.2	-1.2
Medication: Paracetamol	1.1	1.6	3.2	1.2	1.5	0.3	-1.7	0.3	-1.8
Risk taking	1.1	1.6	3.2	-1.4	-1.2	1.8	-0.7	-0.9	1.3
Prostate Cancer	1.0	1.5	3.2	-1.8	-1.7	0.6	0.1	-1.5	0.0
Relative age of first facial hair	1.0	2.1	4.7	0.5	0.5	-0.0	2.2	1.7	2.2
Diabetes (father)	1.0	1.3	3.2	-1.7	-1.8	1.0	-0.1	-0.5	-0.2
Ever taken oral contraceptive pill	1.0	1.1	2.5	-1.3	-1.0	-0.1	0.9	-0.8	1.6
Mother’s age at death	1.0	1.3	2.2	-1.4	-1.5	-0.2	1.3	-1.3	-0.1
Pain type(s) experienced in last month: Hip pain	1.0	1.2	3.0	-1.3	-1.2	-0.6	0.9	-1.7	0.3
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.2	1.8	1.7	-0.2	0.6	0.9	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	3.7	0.6	0.4	-1.9	-0.2	0.4	-1.7
Schizophrenia vs Biploar Disorder	0.9	1.2	2.8	0.8	0.8	-0.9	-1.7	0.6	-1.4
Medication: Metformin	0.9	1.2	5.9	-0.6	-0.4	2.4	-0.3	0.1	-0.9
Taking other prescription medications	0.9	1.4	3.8	1.0	1.0	-1.9	0.9	1.1	-0.9
Gout (self-reported)	0.9	1.3	2.2	1.1	0.5	-1.5	1.1	1.5	0.8
Pulse rate, automated reading	0.9	2.9	6.6	-1.3	-1.2	-1.3	-2.6	-1.1	-2.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.0	1.7	1.2	0.9	0.9	0.8	1.3	0.8
Average weekly beer plus cider intake	0.9	1.2	4.0	0.1	0.3	1.4	1.2	0.1	2.0
Ever depressed for a whole week	0.9	1.1	2.0	-1.4	-1.3	1.4	0.4	-0.9	0.2
Crohns Disease (2017)	0.8	1.7	9.1	0.4	0.1	-3.0	-0.2	-0.2	-1.1
Mean Putamen Volume	0.8	0.9	2.7	1.1	1.1	-0.3	0.2	1.6	-0.4
Sensitivity / hurt feelings	0.8	1.3	4.2	0.7	0.7	0.0	2.0	0.9	1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.7	0.1	0.2	-0.5	-1.2	0.1	-1.9
Hand grip strength (right)	0.8	2.3	5.0	1.8	1.9	-0.8	0.9	2.2	0.8
Mouth/teeth dental problems	0.8	1.2	5.1	0.7	0.9	0.2	-2.3	0.5	-0.7
Illnesses of siblings	0.8	1.1	2.1	0.8	1.1	1.4	-1.4	0.7	0.1
Father’s age at death	0.8	1.1	2.2	-1.3	-1.1	-0.2	1.5	-0.6	0.9
Lung cancer (father)	0.8	0.9	3.1	-0.4	-0.4	-0.4	-1.3	-0.5	-1.8
Number of children fathered	0.8	0.9	1.7	-0.8	-0.9	-0.8	0.3	-1.3	1.3
Medication: Allopurinol	0.8	1.0	2.0	0.9	0.6	-1.4	1.3	1.0	0.6
Overall health rating	0.8	1.7	3.1	1.1	1.3	-1.3	-1.5	0.3	-1.8
Knee pain experienced in last month	0.8	1.2	2.9	1.1	1.1	-1.3	-0.5	0.4	-1.7
Average weekly red wine intake	0.8	1.2	2.2	-1.4	-1.3	-0.6	-1.0	-1.5	0.4
Back pain experienced in last month	0.8	1.1	2.7	-0.9	-1.0	-1.6	-0.5	-1.4	-0.4
Medication: Gliclazide	0.8	1.0	3.7	-0.1	0.0	0.7	-1.2	0.0	-1.9
Miserableness	0.8	1.4	3.1	1.0	1.1	1.8	0.4	1.4	0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.4	-0.8	-0.8	-0.5	-1.6	-1.1	-0.3
Illnesses of father: High blood pressure	0.8	1.0	2.0	-1.1	-1.4	-1.0	0.3	-1.3	0.6
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	-0.4	-0.3	1.2	1.5	0.3	1.2
Schizophrenia (2018)	0.7	1.4	3.6	0.9	1.3	0.6	1.2	0.6	1.9
Irritable Bowel Disease (IBD)	0.7	1.6	7.1	0.3	0.1	-2.7	-0.8	-0.5	-1.3
Cardiovascular Disease	0.7	2.4	5.9	-1.9	-2.0	-1.0	-0.2	-2.4	-0.1
Ever had hysterectomy (womb removed)	0.7	0.8	3.4	0.5	0.6	0.1	1.8	-0.1	0.9
Diabetes (mother)	0.7	0.9	2.1	0.1	0.2	-1.1	-1.4	0.3	-1.4
High blood pressure (mother)	0.7	0.9	3.4	-0.9	-1.0	-0.7	-0.3	-1.8	-0.1
Alcohol usually taken with meals	0.7	1.2	2.9	-1.4	-1.4	-0.3	-0.3	-1.7	-0.5
Worrier / anxious feelings	0.7	1.4	2.8	-1.1	-1.2	-1.7	-0.4	-1.2	-1.1
Illnesses of mother	0.7	0.9	3.3	0.7	0.8	1.8	-0.4	0.7	-0.2
Chest pain or discomfort	0.7	1.1	2.0	0.9	1.0	-0.8	1.4	1.1	-0.8
Had major operations	0.7	0.8	1.7	0.7	0.7	1.0	1.3	1.0	-0.3
Supplements: Vitamin C	0.7	0.8	1.5	1.0	0.7	-1.2	0.5	0.6	1.0
Commuting to job workplace: Walk	0.7	0.7	2.3	-0.1	-0.3	-0.5	-1.5	-0.6	-1.2
Guilty feelings	0.7	1.0	4.5	0.8	0.4	-0.3	0.9	2.1	0.4
Ever had prostate specific antigen (PSA) test	0.7	0.9	2.2	0.4	0.5	-0.4	1.4	0.8	1.5
Diastolic blood pressure, automated reading	0.7	2.1	4.2	-1.8	-1.7	-1.3	0.8	-2.0	0.3
Alzheimer’s Disease (in mother)	0.6	0.6	2.6	-0.4	-0.3	-0.2	1.6	0.2	1.0
Alzheimer’s Disease (in father)	0.6	0.6	2.2	0.2	0.1	-1.5	-0.0	0.6	-1.0
Breast Cancer	0.6	1.3	2.2	1.3	1.4	0.3	-0.5	1.3	-1.5
Age at First Birth	0.6	0.9	1.5	1.0	0.9	-0.8	0.9	0.9	1.2
Coronary Artery Disease (CAD)	0.6	0.7	2.0	0.3	0.5	1.4	-0.1	1.2	-0.4
LDL Cholesterol	0.6	1.0	2.1	1.0	0.9	-1.5	1.2	0.7	-0.3
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.4	0.8	0.8	-0.6	-0.5	1.5	-0.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.3	-0.5	-0.4	1.4	-1.5	-0.4	-1.2
Lung FVC	0.6	3.0	7.2	0.0	-0.0	2.6	2.0	0.3	2.7
Neuroticism	0.6	1.4	6.2	0.1	0.1	0.7	1.2	0.4	2.5
Severe depression (siblings)	0.6	0.7	2.7	-0.1	-0.2	-0.9	1.6	-0.1	0.8
Maternal smoking around birth	0.6	0.9	2.7	0.2	0.2	-0.9	-0.9	0.9	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.2	1.1	1.1	0.6	-0.4	1.1	0.7
Stomach or abdominal pain in last month	0.6	0.7	1.7	0.3	0.5	1.3	1.2	0.9	-0.0
Diabetes (self-reported)	0.6	0.9	1.5	0.5	0.6	0.8	-1.2	0.9	-1.2
Mouth/teeth dental problems: Dentures	0.6	1.0	5.9	-0.2	-0.2	0.1	2.4	-0.2	0.4
Medication: Lansoprazole	0.6	0.7	2.5	0.4	0.6	0.3	1.6	1.0	0.0
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.2	1.1	1.2	0.3	0.1	1.8	0.1
Age at first live birth	0.6	1.0	3.4	-0.8	-0.6	1.9	-0.3	-1.0	0.7
Health satisfaction	0.6	0.7	1.8	-0.1	0.1	-1.2	-0.6	-0.8	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.5	-0.8	-0.6	1.1	-0.6	0.1	-1.2
Suffer from ‘nerves’	0.6	0.9	2.8	-0.9	-0.7	0.4	0.2	-0.9	1.7
Qualifications: nursing, teaching	0.6	1.0	1.9	0.9	1.0	-0.1	1.1	1.4	1.0
Medication for cholesterol	0.6	0.8	2.2	-0.8	-1.0	0.4	-0.8	-0.6	-1.5
Smoking status: Current	0.6	0.9	1.4	-1.0	-0.6	0.9	-1.1	-0.8	-1.2
Eye problems/disorders: Glaucoma	0.6	0.7	1.8	0.7	0.8	-0.7	0.7	0.1	1.4
Alcohol drinker status: Never	0.6	0.7	1.2	-0.9	-1.0	0.3	1.0	-1.1	-0.1
Irritability	0.6	1.0	4.4	0.1	-0.2	0.8	0.9	0.3	2.1
Fractured/broken bones in last 5 years	0.6	0.7	1.6	1.0	1.0	0.4	-0.7	1.3	0.3
Commuting to job workplace: Cycle	0.6	0.7	2.0	-1.2	-1.4	-0.1	0.4	-0.8	0.2
Myopia	0.6	0.9	2.8	0.4	0.9	0.9	-1.7	0.6	-0.6
Cholesterol lowering medication	0.6	0.9	1.9	0.6	0.5	-1.0	-1.2	0.6	-1.4
Worry (Nagel 2018)	0.5	1.1	3.1	-1.1	-1.1	-0.3	-1.1	-1.8	0.2
Ovarian Cancer	0.5	0.7	1.2	0.9	0.8	-1.1	0.5	1.0	-0.5
Hypothyroidism (self reported)	0.5	1.1	4.3	0.8	0.4	-2.1	1.1	0.4	0.6
Impedance of leg (right)	0.5	2.6	6.8	-0.3	-0.3	2.5	1.5	0.2	2.6
Townsend deprivation index at recruitment	0.5	0.7	1.6	-0.1	-0.4	-1.3	-1.0	0.5	-1.1
Current tobacco smoking	0.5	0.8	1.4	-1.2	-0.8	0.8	-0.7	-1.1	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	2.1	-0.9	-0.9	-1.1	-1.2	-0.9	-1.5
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.2	0.8	0.8	-0.3	0.6	0.6	-1.1
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.7	-0.8	-0.7	1.3	-0.7	-0.4	0.1
Number of incorrect matches in round	0.5	0.8	3.0	0.9	0.9	-0.3	1.7	-0.0	0.5
Number of live births	0.5	0.7	2.0	-0.4	-0.5	-1.0	-1.0	-0.3	-1.4
Noisy workplace	0.5	0.6	1.4	1.2	1.0	-0.2	-0.4	0.5	-0.8
Asthma	0.5	1.0	3.5	0.2	0.4	0.5	1.9	0.1	1.3
Tense / ‘highly strung’	0.5	0.9	4.9	0.3	-0.0	-2.2	-0.3	0.3	-0.3
Birth weight of first child	0.5	1.0	2.7	-0.0	-0.4	-1.6	-1.2	-1.1	-0.5
Peak expiratory flow (PEF)	0.5	1.1	1.8	-1.4	-1.2	1.4	-0.4	-0.7	1.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	0.0	0.3	1.3	0.6	-0.1	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	-1.1	-1.2	0.1	0.1	-0.9	0.6
Mean time to correctly identify matches	0.5	0.9	2.3	1.1	1.0	0.7	0.4	0.7	1.5
Leg pain on walking	0.5	0.6	3.1	0.2	0.2	-1.8	0.5	0.2	-0.4
Diabetes diagnosed by doctor	0.5	0.8	2.6	0.2	0.3	1.6	-1.1	0.5	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.7	-0.1	-0.0	-0.6	1.3	0.4	1.0
Osteoarthritis (self-reported)	0.5	0.7	2.5	0.6	0.6	-0.7	0.0	0.4	-1.6
High cholesterol (Self-reported)	0.5	0.9	2.4	0.6	0.4	-0.8	-1.1	0.7	-1.5
Reaction Time	0.4	0.7	1.9	0.8	0.7	0.6	-0.1	0.8	1.4
Serious illness, injury or assault to yourself	0.4	0.5	2.1	0.2	0.2	-1.5	0.6	0.3	-0.1
High blood pressure	0.4	1.0	2.4	-0.8	-0.8	-1.4	0.1	-1.6	-0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	0.6	0.5	-0.9	0.6	0.5	1.0
Impedance of leg (left)	0.4	2.0	6.4	-0.1	0.1	2.5	0.9	0.7	2.0
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	1.0	1.1	-0.5	0.9	0.3	0.2
Had menopause	0.4	0.5	1.5	0.2	0.2	-0.7	1.2	-0.3	-0.8
Had other major operations	0.4	0.5	1.0	-1.0	-1.0	-0.0	0.1	-0.8	0.7
Heart attack	0.4	0.5	1.5	0.3	0.1	-1.2	-0.5	-0.2	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.9	0.8	0.7	-0.5	0.9	0.3	1.4
Depression (self-reported)	0.4	0.5	0.9	-0.8	-0.7	0.4	1.0	-0.6	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	2.7	-1.5	-1.7	0.4	-0.1	-1.2	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	1.5	-0.8	-1.0	-1.2	0.6	-0.5	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.9	0.8	0.4	-1.7	0.8	0.4	0.3
Medication: Amlodipine	0.4	0.6	1.5	0.8	0.7	-0.4	-1.2	0.6	-0.6
High blood pressure (siblings)	0.4	0.5	1.6	-0.4	-0.4	-1.0	1.3	-0.5	0.3
Pulse wave peak to peak time	0.4	0.4	0.8	-0.8	-0.9	0.5	0.7	-0.1	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	1.0	1.2	0.6	-0.3	-0.2	0.3
Hypertension (Self-reported)	0.4	1.1	2.8	-0.8	-0.9	-1.4	-0.1	-1.7	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.6	-0.6	-0.3	0.7	1.3	-0.2	0.2
Illnesses of father: Heart disease	0.4	0.6	1.4	-0.1	-0.3	-1.2	0.7	1.1	0.8
Arm fat percentage (left)	0.4	1.5	4.8	0.0	0.0	-1.7	-0.9	0.3	-2.2
Asthma (self-reported)	0.4	0.8	3.3	0.2	0.4	0.3	1.8	0.0	1.1
Average weekly champagne plus white wine intake	0.4	0.5	1.4	0.6	0.9	1.2	-0.2	0.7	0.0
Medication: Blood pressure	0.4	0.7	1.3	-0.8	-0.8	-1.1	0.7	-1.1	0.1
Number of operations (self-reported)	0.4	0.6	1.6	0.0	0.1	1.2	1.3	0.5	0.3
Age started oral contraceptive pill	0.4	0.5	1.2	1.1	1.1	0.1	0.3	0.9	0.3
Heart disease (siblings)	0.4	0.5	1.7	0.7	0.6	0.1	1.3	0.8	0.0
Pack years of smoking	0.4	0.6	2.1	0.5	0.5	-0.7	-0.7	0.1	-1.4
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	-0.3	-0.2	1.5	0.9	0.2	0.7
Depression (Nagel 2018)	0.3	0.4	0.9	0.4	0.4	1.0	-0.7	0.7	0.7
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.7	-0.5	-0.4	1.3	-1.9	-0.2	0.2
Neuroticism (Nagel 2018)	0.3	0.7	1.3	-1.1	-1.1	0.3	0.2	-1.1	0.8
Alzheimer’s Disease (including proxy)	0.3	0.5	1.1	0.2	0.2	-0.8	1.0	1.0	0.5
BMI	0.3	1.5	3.1	1.3	1.3	-0.9	0.0	1.8	-1.3
Respiratory disease	0.3	0.6	2.4	-0.1	0.1	1.5	1.1	0.0	0.4
Number of treatments/medications taken	0.3	0.5	1.7	0.5	0.7	-1.3	0.6	-0.2	-0.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.5	0.3	0.3	0.2	0.0	0.4	1.6
Systolic blood pressure, automated reading	0.3	0.8	2.1	-0.6	-0.6	-1.4	0.3	-1.3	0.1
Angina	0.3	0.4	1.8	0.3	0.4	-0.0	0.8	0.1	1.3
Supplements: Zinc	0.3	0.3	1.3	0.3	0.2	1.1	0.4	0.1	0.3
Medication: Co-codamol	0.3	0.3	1.2	-0.2	0.1	-0.8	0.0	0.1	-1.1
Pack years adult smoking proportion	0.3	0.5	1.6	0.4	0.5	-0.4	-0.7	-0.0	-1.3
Leg fat-free mass (left)	0.3	1.4	4.0	-0.2	-0.3	-2.0	-0.9	-0.3	-1.9
Fed-up feelings	0.3	0.5	1.8	0.2	-0.0	-1.3	-0.5	0.4	-0.8
Medication: Levothyroxine sodium	0.3	0.6	0.9	0.8	0.6	-0.2	0.9	0.8	1.0
Sitting height	0.3	2.3	4.4	-2.0	-2.1	-0.7	-0.5	-2.1	0.1
Body mass index (BMI)	0.3	1.3	3.7	0.8	0.8	-1.1	-0.4	1.1	-1.9
Leg predicted mass (left)	0.3	1.6	4.2	-0.2	-0.3	-2.0	-1.0	-0.3	-2.0
Fluid intelligence score	0.3	0.7	2.6	-0.8	-0.7	-0.4	-1.6	-0.3	-0.1
Neuroticism score	0.3	0.6	2.4	0.4	0.2	-0.3	0.9	0.6	1.6
Weight	0.3	1.3	3.9	-0.2	-0.2	-2.0	-0.6	0.0	-1.9
Arm fat percentage (right)	0.3	1.4	4.2	0.2	0.1	-1.9	-0.6	0.3	-2.1
Hip circumference	0.3	1.2	3.2	-1.1	-1.1	-1.1	0.4	-0.6	-1.8
Falls in the last year	0.3	0.4	0.8	0.9	0.8	-0.7	-0.1	0.7	0.0
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	3.2	-0.8	-0.7	1.0	-0.0	-0.6	1.8
Medication: Cholesterol lowering	0.3	0.5	1.2	-0.6	-0.4	1.1	-0.5	-0.8	-0.4
Pulse wave Arterial Stiffness index	0.3	0.4	0.6	0.4	0.6	-0.8	-0.8	-0.3	-0.6
Impedance of arm (left)	0.3	1.2	2.8	-1.4	-1.3	0.1	-0.4	-1.7	0.8
Arm fat mass (right)	0.3	1.1	3.4	0.2	0.1	-1.7	-0.5	0.3	-1.8
Standing height	0.3	2.8	4.7	-2.1	-2.1	-1.7	-0.3	-2.2	0.3
Pulse wave reflection index	0.3	0.3	0.5	0.6	0.7	0.3	-0.4	0.7	0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.9	-0.7	-0.9	-0.6	0.5	-0.4	0.3
Medication: Paracetamol	0.3	0.6	1.4	0.7	0.8	0.4	-1.2	-0.2	-0.9
Headache pain in last month	0.3	0.5	1.1	-0.2	0.2	1.1	0.8	-0.0	1.0
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.8	0.8	0.9	-0.6	-0.0	0.9	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.4	0.9	0.3	0.1	-1.0	-0.9	-0.2	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	2.8	-1.5	-1.7	0.1	-0.2	-1.1	0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.5	-0.0	0.2	-1.2	0.1	-0.2	-1.1
Medication: Blood pressure	0.3	0.5	1.1	-0.9	-1.0	0.5	0.1	-1.0	-0.0
Medication: Ibuprofen	0.3	0.3	0.7	0.6	0.5	0.8	-0.3	0.0	0.8
Heart disease (mother)	0.3	0.3	0.7	-0.6	-0.7	-0.8	0.4	-0.2	0.5
Number of full sisters	0.3	0.4	1.3	-0.3	-0.6	-0.7	1.1	-0.4	0.2
Smoking status: Previous	0.3	0.4	1.5	0.4	0.3	-0.1	1.2	0.2	0.7
Leg fat-free mass (right)	0.3	1.7	4.5	-0.3	-0.3	-2.0	-1.2	-0.2	-2.1
Ever had bowel cancer screening	0.3	0.4	0.6	0.8	0.6	-0.7	0.8	0.4	0.2
Eye problems/disorders: Cataract	0.3	0.3	0.8	0.8	0.9	0.2	0.3	0.7	-0.1
Mineral and other dietary supplements	0.3	0.5	0.9	-0.7	-0.7	1.0	0.0	-0.2	0.9
Osteoporosis (self-reported)	0.3	0.3	1.6	-0.2	-0.2	0.4	1.3	0.1	0.5
Leg predicted mass (right)	0.3	1.6	4.1	-0.4	-0.4	-2.0	-1.1	-0.3	-2.0
Arm fat mass (left)	0.3	1.3	4.1	-0.0	-0.0	-1.8	-0.7	0.2	-2.0
Hearing aid user	0.3	0.4	0.8	0.3	0.3	-0.9	-0.7	-0.4	-0.9
Medication: Atorvastatin	0.3	0.3	1.4	0.6	0.3	-1.2	0.2	0.3	-0.1
Supplements: Calcium	0.3	0.3	1.0	0.5	0.4	-1.0	0.1	0.5	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.3	0.3	0.2	-1.1	-0.3	-0.1	-0.9
Crohns Disease (2012)	0.2	0.3	0.9	-0.3	-0.3	-0.6	-0.4	-0.6	-0.9
HbA1C	0.2	0.2	0.6	-0.4	-0.5	0.3	-0.4	-0.2	-0.8
HDL Cholesterol	0.2	0.3	0.8	0.6	0.6	0.9	-0.2	0.5	0.2
Neuroticism (2016)	0.2	0.2	0.5	-0.4	-0.4	-0.1	0.7	-0.1	0.7
Rheumatoid Arthritis	0.2	0.3	0.8	-0.5	-0.1	0.4	-0.3	-0.9	0.5
Ulcerative Colitis	0.2	0.3	0.8	-0.3	0.1	0.9	0.6	-0.5	0.6
Blood Eosinophil Count	0.2	1.2	2.6	1.3	1.2	-0.4	-0.4	1.2	1.6
Blood Platelet Count	0.2	1.7	3.1	-1.4	-0.9	1.3	0.7	-1.8	1.5
Heel T-Score	0.2	1.9	4.3	1.5	1.9	-0.2	0.6	2.1	-1.0
Chronotype (morning person)	0.2	0.4	0.8	-0.8	-0.9	-0.7	-0.0	-0.7	-0.4
Trunk fat percentage	0.2	0.6	1.9	0.5	0.6	-0.9	-0.0	0.7	-1.4
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.3	-0.2	-0.5	0.8	-0.4	-0.2
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	0.5	0.0	-1.1	0.5	0.6	0.8
Medication: Atenolol	0.2	0.3	0.8	-0.3	-0.3	0.4	0.9	-0.5	-0.4
Trunk fat mass	0.2	0.8	2.7	0.1	0.1	-1.4	-0.3	0.4	-1.6
Waist circumference	0.2	0.8	2.5	0.2	0.3	-1.5	-0.0	0.3	-1.6
Forced vital capacity (FVC)	0.2	0.8	2.1	-0.9	-0.8	0.7	-0.1	-0.7	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.7	-0.0	0.0	-0.5	-0.4	0.3	-1.3
Qualifications: None of the above	0.2	0.5	2.1	-0.3	-0.4	-0.6	0.2	-0.5	-1.4
Pain all over the body in last month	0.2	0.2	0.6	-0.2	-0.1	-0.3	0.6	0.0	0.8
Medication: Simvastatin	0.2	0.3	0.5	-0.7	-0.4	0.7	-0.1	-0.7	-0.5
Impedance of arm (right)	0.2	1.1	2.5	-1.2	-1.1	0.2	0.3	-1.6	1.2
Trunk fat-free mass	0.2	1.4	3.2	-1.1	-1.2	-1.8	-0.7	-1.0	-0.9
Hair/balding pattern: Pattern 3	0.2	0.2	0.7	-0.4	-0.3	0.8	-0.6	0.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.3	0.3	0.8	0.4	-0.2	0.7
Trunk predicted mass	0.2	1.2	2.9	-1.1	-1.2	-1.7	-0.6	-0.9	-1.0
Length of working week for main job	0.2	0.3	0.7	-0.7	-0.5	0.2	0.2	-0.8	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.7	-0.6	-0.1	0.2	-0.2	0.3
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-1.0	-1.0	0.5	-0.3	-0.9	-0.2
Birth weight	0.2	0.4	0.7	0.8	0.8	-0.7	0.6	0.5	0.2
Body fat percentage	0.2	0.8	2.2	0.5	0.6	-1.2	-0.1	0.8	-1.5
Comparative body size at age 10	0.2	0.6	0.9	1.0	0.9	0.3	0.5	0.9	-0.8
Shortness of breath walking on level ground	0.2	0.2	0.5	0.5	0.7	-0.3	0.5	-0.3	-0.5
Qualifications: College or University degree	0.2	0.7	3.6	-0.2	-0.3	0.5	0.6	-0.4	1.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.0	0.2	0.1	0.1	1.0	0.4	-0.4
Angina (self-reported)	0.2	0.3	1.2	0.3	0.4	-0.0	0.6	0.1	1.1
Whole body fat mass	0.2	0.9	2.9	0.1	0.0	-1.5	-0.4	0.3	-1.7
Leg fat mass (right)	0.2	0.8	2.5	0.4	0.3	-1.1	-0.1	0.9	-1.6
Age at last live birth	0.2	0.3	1.2	-0.1	0.0	1.1	0.5	0.1	0.8
Family relationship satisfaction	0.2	0.3	0.8	0.6	0.7	-0.2	-0.9	0.3	0.1
Whole body fat-free mass	0.2	1.2	3.2	-0.7	-0.8	-1.8	-0.8	-0.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.3	-0.5	-0.8	-1.2	-0.2	-0.0	0.0
Whole body water mass	0.2	1.2	3.0	-0.7	-0.8	-1.7	-0.9	-0.5	-1.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.7	0.1	0.2	-0.7	1.3	0.4	0.4
Wears glasses or contact lenses	0.2	0.2	0.6	-0.2	-0.0	-0.4	0.7	-0.8	0.2
Basal metabolic rate	0.2	1.2	3.3	-0.6	-0.7	-1.8	-0.8	-0.4	-1.5
Leg fat percentage (left)	0.2	0.8	2.0	0.7	0.7	-0.4	0.4	1.3	-1.4
Unable to work because of sickness or disability	0.2	0.2	0.4	0.4	0.4	-0.6	0.6	0.5	0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.7	0.4	0.4	1.2	-0.2	1.3	0.3
Impedance of whole body	0.2	1.0	2.3	-0.8	-0.6	1.3	0.2	-0.8	1.5
Leg fat mass (left)	0.2	1.0	3.0	0.5	0.4	-1.0	-0.1	1.2	-1.7
Ulcerative Colitis (UC)	0.1	0.1	0.3	-0.0	0.1	-0.5	-0.5	-0.1	-0.4
Major Depression (MDD)	0.1	0.1	0.6	-0.2	0.1	-0.2	0.8	0.1	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.4	-0.4	-0.2	0.5	-0.6	0.0	0.3
Primary Biliary Cirrhosis	0.1	0.1	0.2	-0.3	-0.2	0.2	0.0	-0.5	0.3
Blood Red Count	0.1	1.2	4.4	0.2	0.1	0.2	1.6	-0.3	2.1
Height	0.1	1.5	5.4	-0.6	-0.5	-2.3	-0.7	-0.4	-1.6
Waist Hip Ratio (WHR)	0.1	0.5	1.2	1.0	1.1	-0.8	-0.1	0.1	0.3
Smoking Status	0.1	0.2	0.7	-0.1	0.2	0.7	-0.3	-0.0	-0.9
Allergy or Eczema	0.1	0.3	0.8	0.2	-0.1	-0.9	0.4	0.1	0.9
Hair Pigment	0.1	2.1	3.2	1.7	1.4	-1.8	1.7	1.1	0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.4	-0.4	-0.6	-0.2	0.2	-0.7
Supplements: Glucosamine	0.1	0.1	0.2	0.2	0.4	-0.1	-0.3	0.5	-0.4
Past tobacco smoking	0.1	0.2	0.3	-0.5	-0.6	-0.3	-0.3	-0.5	-0.4
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4	0.4	0.4
Allergy	0.1	0.3	1.4	-0.4	-0.1	1.2	-0.1	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.4	0.5	0.6	0.1	-0.1	0.4	-0.4
Leg fat percentage (right)	0.1	0.4	1.0	0.3	0.4	-0.4	0.6	0.7	-1.0
Arm fat-free mass (right)	0.1	0.5	1.3	-0.2	-0.3	-1.0	-0.8	0.2	-1.1
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.1	0.0	0.3	0.1	0.5	0.6
Medication for pain relief, constipation, heartburn	0.1	0.3	0.5	-0.5	-0.7	0.2	-0.0	0.5	0.7
Arm predicted mass (right)	0.1	0.5	1.1	0.0	0.0	-0.9	-0.8	0.4	-1.0
Mood swings	0.1	0.1	0.3	-0.5	-0.5	0.5	0.1	0.2	0.0
Loneliness, isolation	0.1	0.2	0.3	-0.1	-0.1	0.5	-0.4	0.6	0.6
Long-standing illness, disability or infirmity	0.1	0.2	0.3	0.3	0.4	-0.2	0.4	0.4	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.8	-0.6	-0.9	-0.1	0.4	-0.5	0.0
Ever smoked	0.1	0.2	0.8	-0.2	-0.1	0.9	0.1	0.2	0.6
Arm fat-free mass (left)	0.1	0.7	2.0	-0.2	-0.3	-1.4	-0.6	0.1	-1.3
Arm predicted mass (left)	0.1	0.5	1.4	-0.0	-0.0	-1.1	-0.6	0.1	-1.2
Triglycerides	0.0	0.0	0.1	-0.0	0.1	0.3	0.2	0.2	-0.1
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.2	-0.2	0.5	0.3	-0.3	0.5
Tanning	0.0	0.4	0.7	0.8	0.3	-0.7	-0.8	0.6	-0.6
Average weekly fortified wine intake	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.1	-0.3	0.2

Hub : Genes

PREX2

Models

Trait associations