Hub : Genes

PRKAR1A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1190	0.0460	9.5e-03	0.055	NA	0.084	NA	0.079	5.3e-04	NA	2.1e-05	NA	3.9e-05
2	GTEx	Artery Tibial	0.2489	0.0452	4.4e-10	0.219	NA	0.234	NA	0.230	4.5e-17	NA	2.9e-18	NA	5.9e-18
3	GTEx	Testis	0.2720	0.0740	1.7e-04	0.118	NA	0.118	NA	0.146	6.4e-06	NA	6.7e-06	NA	5.3e-07
4	NTR	Blood	0.0198	0.0083	7.3e-03	0.000	0.005	0.001	0.005	0.000	3.8e-01	0.0081	1.5e-01	0.0087	2.3e-01
5	TCGA	Brain Lower Grade Glioma	0.0455	0.0258	7.6e-03	0.007	0.019	0.022	NA	0.017	5.0e-02	0.0029	1.5e-03	NA	4.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.6	6.9	-0.6	-0.7	-0.2	0.3	-2.6
Bipolar Disorder or Schizophrenia	0.7	1.7	7.3	0.1	-0.2	-1.1	-0.2	-2.7
Depressed Affect (Nagel 2018)	0.1	0.3	0.9	-0.3	-0.2	-0.9	0.6	0.1
Depression (Nagel 2018)	0.3	0.4	1.9	0.0	-0.1	-0.1	1.4	0.3
Intelligence (Savage-Jansen 2018)	0.9	2.7	6.2	0.9	1.5	1.7	1.2	2.5
Neuroticism (Nagel 2018)	0.1	0.1	0.3	0.5	0.6	0.0	-0.0	0.3
Schizophrenia (2018)	0.4	0.8	1.9	0.6	0.3	-1.2	-0.5	-1.4
Schizophrenia vs Biploar Disorder	1.6	2.1	4.5	2.1	1.6	-0.9	0.2	1.7
Worry (Nagel 2018)	0.5	1.0	1.5	1.1	1.2	1.2	-1.0	0.2
Alzheimer’s Disease (in mother)	0.7	0.8	2.8	-0.5	-0.6	-0.6	-0.4	-1.7
Alzheimer’s Disease (in father)	0.4	0.5	1.3	-0.6	-0.2	0.3	-0.8	1.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.3	-1.1	-1.1	-0.5	-1.0	-0.8
Crohns Disease (2017)	0.3	0.7	1.7	1.0	1.3	-0.5	-0.7	-0.3
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.0	0.0	0.0	-0.3	0.3
Ulcerative Colitis (UC)	0.4	0.7	1.2	-1.0	-1.1	0.7	-0.2	1.0
Major Depression (MDD)	0.8	1.0	3.5	0.6	0.8	1.9	-0.2	-0.6
Reaction Time	0.7	1.4	5.5	-0.5	-0.6	2.3	-0.2	0.9
Verbal and Numeric Reasoning (VNR)	1.0	2.5	4.1	1.2	2.0	1.6	0.7	1.9
Breast Cancer	2.9	7.1	11.9	-2.9	-1.9	-2.7	3.5	-2.0
Ovarian Cancer	0.5	0.6	2.4	-0.5	0.6	-0.1	-1.6	-0.4
Prostate Cancer	3.0	4.2	9.8	-2.7	-3.1	-1.8	0.2	-0.5
Age at First Birth	0.5	0.7	2.1	-0.2	-0.4	1.4	-1.0	0.7
Bipolar Disorder (2011)	0.1	0.1	0.1	0.3	-0.3	0.3	0.4	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.7	-0.7	-1.0	-1.3	-0.0	-0.5
Coronary Artery Disease (CAD)	6.3	7.6	13.0	-3.6	-3.5	-0.5	2.1	-2.7
Crohns Disease (2012)	0.2	0.3	1.3	0.3	0.4	0.1	-0.2	-1.1
Mean Putamen Volume	0.4	0.4	1.0	-0.3	-0.5	0.7	-1.0	0.6
Fasting Glucose	1.3	1.5	4.6	1.5	2.1	0.4	-0.4	0.6
HbA1C	2.3	2.5	10.5	-0.9	-0.3	-1.0	-0.3	-3.2
HDL Cholesterol	2.3	3.8	6.9	1.9	1.4	0.3	-2.6	2.5
LDL Cholesterol	1.2	1.9	5.2	-2.0	-2.3	-0.5	0.2	-0.4
Lupus	0.7	1.0	3.5	-1.1	-1.9	0.1	-0.3	-0.5
Neuroticism (2016)	0.1	0.1	0.4	-0.5	0.2	-0.1	-0.0	-0.6
Primary Biliary Cirrhosis	0.3	0.4	1.9	0.2	0.2	-0.0	-1.4	0.4
Rheumatoid Arthritis	0.1	0.2	0.3	-0.6	-0.6	0.3	0.2	-0.5
Schizophrenia (2014)	0.5	1.0	2.8	0.9	0.5	-1.1	0.1	-1.7
Triglycerides	1.1	1.8	4.6	1.3	2.2	1.6	-0.2	0.2
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.4	-0.4	-0.1	-1.2	-0.1	0.1
Ulcerative Colitis	0.6	0.9	1.7	-0.4	-0.9	1.3	-0.7	1.2
Blood Eosinophil Count	0.1	0.5	1.3	-0.4	0.1	-1.1	0.0	-1.1
Blood Platelet Count	0.8	8.7	20.0	1.3	1.5	4.5	-4.0	-1.9
Blood Red Count	0.2	1.9	4.8	2.2	2.0	-0.6	0.3	-0.3
Blood White Count	0.3	2.2	3.4	1.5	1.4	1.2	-1.5	-1.8
Heel T-Score	0.3	2.2	8.0	0.3	1.1	-2.8	-1.3	0.2
BMI	0.7	3.9	10.9	-1.1	-0.6	-3.3	2.4	-1.2
Height	0.3	6.5	13.4	-3.5	-3.7	-1.1	-1.8	1.4
Waist Hip Ratio (WHR)	0.7	3.2	8.0	1.2	1.5	0.5	2.8	2.0
Systolic Blood Pressure	0.2	0.9	1.4	-0.8	-0.7	0.7	1.2	-1.2
Smoking Status	0.7	1.8	3.4	1.4	1.8	1.8	0.4	0.5
Allergy or Eczema	0.8	2.1	4.3	2.1	2.1	0.5	-0.7	1.2
Cardiovascular Disease	0.4	1.2	3.1	-1.5	-1.8	-0.4	0.2	-0.6
Hypothyroidism (self reported)	0.3	0.7	1.2	0.1	-0.3	-0.9	1.1	1.1
Respiratory disease	0.5	1.0	2.6	1.6	1.6	-0.1	0.2	0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.9	0.3	0.3	-1.7	1.0	0.8
Lung FEV1/FVC ratio	0.4	1.9	7.7	-0.8	-1.0	-0.3	-2.8	-0.1
Lung FVC	0.1	0.6	1.3	0.3	0.5	1.0	-0.5	-1.1
Neuroticism	0.1	0.1	0.3	0.2	0.2	-0.5	0.5	-0.0
Chronotype (morning person)	0.6	1.3	3.0	-0.6	-0.4	-1.4	-0.9	-1.7
Hair Pigment	0.0	0.2	0.6	-0.3	-0.5	-0.4	0.7	0.5
Tanning	0.1	1.1	2.4	-1.1	-1.4	0.3	0.1	-1.5
Hand grip strength (left)	0.9	2.4	6.5	-1.6	-2.6	-0.7	-0.0	-1.6
Number of treatments/medications taken	0.5	0.9	1.9	-0.8	-1.2	0.1	-0.6	-1.4
Average weekly spirits intake	0.9	1.2	2.2	-1.4	-1.5	0.5	-0.2	1.2
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.4	-1.0	-0.7	-0.0	0.3
Frequency of depressed mood in last 2 weeks	0.7	1.0	3.1	-0.3	-0.4	-0.1	1.3	1.8
Hearing difficulty/problems: Yes	1.7	2.5	6.9	0.4	0.0	2.4	-0.1	2.6
Relative age of first facial hair	0.4	0.9	2.4	-1.0	-0.7	0.7	-1.6	0.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.6	-1.0	-1.3	0.3	0.2	-0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.2	-0.5	0.2	-0.9	-0.9
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	-0.9	-1.1	-0.2	-1.3	-0.5
Systolic blood pressure, automated reading	2.1	6.2	10.6	-2.2	-2.4	-2.6	3.3	-1.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	4.1	-0.7	-0.4	1.5	0.6	2.0
Angina	0.8	1.1	2.2	-1.3	-0.8	-0.2	-0.9	-1.5
Medication for hormone replacement therapy	1.1	1.2	4.6	0.6	0.5	-0.8	-0.2	-2.2
Vitamin and mineral supplements	0.9	1.2	3.2	-1.6	-1.8	0.0	-0.3	-0.3
Supplements: Zinc	0.7	0.8	1.9	0.8	0.7	0.4	-0.8	1.4
Medication: Co-codamol	2.4	2.7	5.8	-2.3	-2.4	-0.7	1.4	0.2
Medication: Metformin	0.6	0.8	2.1	-0.9	-0.4	-0.5	1.5	-1.0
Diabetes (father)	0.8	1.0	2.6	0.9	0.7	-1.6	1.0	0.4
Diabetes (mother)	1.5	1.9	3.5	1.9	1.7	-1.3	-0.8	1.0
Severe depression (siblings)	1.7	1.9	3.6	1.7	1.9	1.2	-1.1	0.6
Pack years adult smoking proportion	0.3	0.4	1.5	0.6	1.2	-0.3	-0.3	0.2
Impedance of leg (right)	1.3	6.2	10.3	3.1	3.2	1.8	-2.7	0.5
Leg fat-free mass (left)	1.1	5.7	11.0	-2.7	-2.6	-3.3	1.9	0.2
Trunk fat percentage	0.2	0.9	2.1	0.8	1.3	-1.4	0.0	-0.3
Hand grip strength (right)	0.8	2.3	6.6	-1.4	-2.6	-0.9	0.7	-1.2
Townsend deprivation index at recruitment	0.4	0.5	1.0	0.2	0.6	0.6	-1.0	-0.8
Current tobacco smoking	0.7	1.2	2.2	1.0	1.5	1.4	-0.7	0.6
Average weekly fortified wine intake	0.1	0.2	0.4	0.2	0.5	0.2	-0.7	-0.1
Maternal smoking around birth	1.0	1.4	3.4	-1.9	-0.7	-0.9	1.1	-1.0
Fed-up feelings	0.6	1.2	4.5	-0.3	-0.5	-2.1	0.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.8	-0.6	-0.4	-1.2	1.9	-0.7
Relative age voice broke	1.0	1.6	2.7	-1.4	-1.2	-0.2	-1.3	-1.7
Taking other prescription medications	0.4	0.7	2.2	-0.2	-0.4	1.5	-0.7	0.7
Age when periods started (menarche)	0.8	1.9	8.8	-0.3	0.3	-0.1	-3.0	-0.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.7	-0.9	0.0	-0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	1.6	0.4	1.2	-1.2	-1.1	-0.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	-0.7	-0.9	-1.2	0.1	1.3
Qualifications: CSEs or equivalent	1.1	1.5	2.8	1.3	1.5	-1.7	-0.1	-1.0
Serious illness, injury or assault to yourself	0.3	0.4	1.8	0.2	-0.0	1.4	-0.4	-0.2
High blood pressure	1.1	3.1	7.7	-2.5	-2.8	-0.8	0.8	-0.5
Hayfever, allergic rhinitis or eczema	1.6	3.5	6.5	2.4	2.5	0.7	-1.0	2.0
Multivitamins +/- minerals	0.6	0.7	1.5	0.7	0.9	-1.2	0.6	0.6
Stomach or abdominal pain in last month	1.9	2.4	4.0	0.7	1.5	1.8	-2.0	1.4
Supplements: Glucosamine	0.6	0.8	2.8	0.2	0.7	0.5	-1.7	-0.6
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	3.5	0.7	0.9	0.7	-1.9	0.4
Medication: Atenolol	1.0	1.3	2.2	-1.4	-1.5	0.2	-1.0	1.2
Medication: Levothyroxine sodium	0.2	0.4	1.3	0.1	-0.1	-0.2	1.2	0.8
Sitting height	0.6	4.6	9.5	-3.1	-2.7	-2.5	0.1	0.2
Chronic bronchitis/emphysema (father)	1.0	1.2	4.5	0.7	0.8	0.5	0.1	2.1
High blood pressure (mother)	1.0	1.4	5.6	-0.8	-0.8	-0.6	-0.0	-2.4
Body mass index (BMI)	1.0	4.5	12.3	-1.7	-1.2	-3.5	1.9	-1.4
Impedance of leg (left)	1.2	5.8	8.4	2.8	2.9	2.4	-2.6	0.7
Leg predicted mass (left)	1.0	5.6	11.0	-2.7	-2.5	-3.3	1.8	0.2
Trunk fat mass	0.3	1.3	6.0	-0.4	0.0	-2.4	0.5	-0.4
Waist circumference	0.8	2.8	8.2	-1.1	-0.5	-2.9	2.1	-0.2
Number of incorrect matches in round	0.2	0.3	1.0	-0.5	-0.4	0.2	0.0	-1.0
Past tobacco smoking	0.2	0.5	0.8	-0.8	-0.8	-0.9	0.4	0.1
Alcohol usually taken with meals	0.8	1.3	3.9	-1.3	-2.0	0.1	0.8	-0.5
Nervous feelings	0.2	0.5	1.9	0.3	0.4	0.3	-1.4	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	1.8	-1.0	-1.1	-0.5	1.1	1.4
Hearing difficulty/problems with background noise	0.2	0.3	1.0	-0.5	-0.5	1.0	-0.1	0.2
Hair/balding pattern: Pattern 2	1.3	1.7	3.4	-1.1	-1.9	-0.9	0.1	-1.7
Had menopause	0.3	0.4	0.7	-0.3	-0.8	-0.6	0.8	-0.0
Had other major operations	0.5	0.6	1.9	0.5	0.5	1.4	-0.6	-0.3
Forced vital capacity (FVC)	0.1	0.5	1.3	-1.1	-1.0	0.6	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.4	0.8	-0.3	-1.0	0.2
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.6	0.0	-0.5	-0.2	0.0
Qualifications: None of the above	0.4	0.8	2.1	0.2	-0.4	-0.9	-1.0	-1.4
Financial difficulties in last 2 years	0.6	0.8	3.0	0.4	-0.2	-1.7	0.8	0.4
Mouth/teeth dental problems	2.9	4.4	10.0	3.2	2.3	-0.1	-2.0	1.8
Heart attack	2.1	2.6	5.9	-2.2	-2.4	0.6	0.8	-1.2
Allergy	1.3	3.0	5.2	-2.3	-2.2	-1.1	0.5	-1.8
Pain all over the body in last month	0.3	0.3	0.7	0.1	-0.0	-0.8	0.8	-0.6
Diabetes (self-reported)	0.7	1.0	3.1	0.8	0.9	-0.2	0.7	1.8
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	3.8	1.4	2.0	0.8	-0.9	0.7
Medication: Ramipril	2.5	3.2	7.4	-2.7	-2.7	0.7	-0.3	-1.0
Medication: Simvastatin	0.4	0.6	1.6	0.1	-0.2	1.2	-0.4	1.2
Fluid intelligence score	0.5	1.0	3.8	-0.5	-0.3	0.1	1.9	0.9
Illnesses of siblings	0.4	0.6	1.8	0.3	0.1	-0.4	1.3	0.9
Neuroticism score	0.3	0.6	1.2	-0.9	-0.5	-1.1	0.8	-0.6
Weight	1.1	5.2	13.0	-2.4	-2.2	-3.6	1.5	-0.5
Impedance of arm (right)	3.6	17.0	26.4	5.0	5.1	4.1	-3.4	2.2
Arm fat percentage (right)	0.3	1.2	4.7	0.2	0.9	-2.2	0.6	-0.5
Trunk fat-free mass	2.3	13.2	20.8	-4.6	-4.6	-4.5	2.1	-0.4
Hip circumference	0.8	3.6	12.3	-1.8	-1.2	-3.5	0.6	-0.8
Time employed in main current job	2.8	3.2	5.7	1.3	1.7	2.2	-2.4	0.7
Alcohol intake versus 10 years previously	0.7	1.1	2.2	1.2	1.5	-0.8	0.4	-1.1
Father’s age at death	0.5	0.7	2.2	-0.8	-0.3	-0.0	-1.5	-0.6
Worrier / anxious feelings	0.3	0.5	1.9	0.3	0.2	1.4	-0.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.9	0.4	0.7	0.5	1.0	0.7
Falls in the last year	0.6	0.8	1.7	-0.9	-1.3	-0.7	-0.1	-0.9
Hair/balding pattern: Pattern 3	0.7	1.1	4.9	-0.3	-0.3	0.5	-0.3	2.2
Number of live births	2.0	2.8	6.5	-1.6	-1.6	-1.4	2.5	0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.0	-0.8	-0.9	0.2	-1.4	-0.6
Pulse rate	0.7	1.2	1.7	1.1	1.3	0.8	-0.8	1.3
Happiness	1.5	1.9	3.8	1.3	1.9	1.4	0.3	1.4
Noisy workplace	0.9	1.2	2.6	1.6	0.7	0.1	-1.5	0.7
Qualifications: A levels/AS levels or equivalent	1.0	2.1	3.9	1.1	1.3	2.0	2.0	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	-0.9	-0.2	-0.3	0.2	0.6
Mouth/teeth dental problems: Dentures	2.0	3.3	6.0	-2.4	-2.1	-1.4	0.9	-1.8
Asthma	0.2	0.4	0.8	0.5	0.4	-0.7	0.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.3	0.2	0.1	-0.1	-1.5	-1.1
Medication: Cholesterol lowering	1.8	2.7	6.2	-2.2	-2.5	-0.2	1.1	-1.0
Depression (self-reported)	0.7	0.8	2.1	1.0	0.5	0.6	0.6	1.4
Medication: Lansoprazole	1.1	1.2	2.4	0.4	1.0	0.7	-1.4	1.5
Prospective memory result	0.4	0.5	1.6	0.6	0.3	0.4	-1.3	-0.5
Lung cancer (father)	0.8	0.9	1.7	0.6	1.3	0.9	-0.9	0.8
Illnesses of mother	0.7	0.9	2.3	0.8	0.7	0.6	0.9	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.4	3.1	-1.7	-1.8	-0.3	-1.0	-0.5
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	-0.8	-0.8	-0.9	-0.3	0.5
Impedance of arm (left)	3.5	16.2	23.6	4.9	4.8	4.1	-3.5	2.4
Arm fat mass (right)	0.6	2.6	9.2	-1.2	-0.5	-3.0	1.3	-0.7
Trunk predicted mass	2.3	13.1	20.6	-4.5	-4.5	-4.5	2.1	-0.4
Standing height	0.3	3.0	5.8	-2.1	-2.4	-0.7	-0.7	1.9
Length of working week for main job	1.0	1.1	2.3	1.2	1.2	0.3	0.1	1.5
Exposure to tobacco smoke at home	0.7	0.8	1.3	1.1	1.0	-0.5	-0.8	-0.7
Breastfed as a baby	2.8	3.5	7.2	1.2	0.8	2.3	-1.8	2.7
Tense / ‘highly strung’	0.4	0.7	1.7	-0.5	-0.6	0.2	1.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.2	-1.5	-0.9	-1.3	0.1	-1.2
Hair/balding pattern: Pattern 4	1.0	2.4	4.8	1.6	2.2	1.4	-1.1	1.2
Birth weight of first child	0.3	0.6	1.5	0.8	1.2	-0.5	-0.4	-0.7
Peak expiratory flow (PEF)	0.8	1.9	4.1	-2.0	-1.9	-0.5	-0.6	-1.1
Pulse wave reflection index	1.1	1.4	2.1	-1.4	-1.5	-1.3	0.4	-0.9
Ever highly irritable/argumentative for 2 days	1.9	2.2	4.6	-1.8	-1.4	-2.1	1.0	-0.6
Loud music exposure frequency	0.8	0.9	1.8	0.9	1.4	-0.4	-1.3	-0.0
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.3	-0.0	0.3	1.1	0.2	0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.5	0.9	1.0	1.2	-0.3	1.1
Blood clot in the leg (DVT)	0.9	1.1	4.8	-0.2	-0.4	2.2	-0.2	0.7
Medication: Paracetamol	0.8	1.3	5.3	-0.0	0.1	-0.9	-0.7	-2.3
Headache pain in last month	1.0	1.8	4.2	1.5	1.5	-0.2	-2.1	-0.3
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.3	1.7	2.1	0.2	-0.1	0.8
Glaucoma (self-reported)	1.8	2.1	3.0	-1.7	-1.7	1.1	-1.0	-1.5
Gout (self-reported)	0.4	0.5	0.9	-0.8	-0.4	0.9	0.8	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	0.3	-0.3	-0.7	0.8	1.2
Medication: Amlodipine	0.4	0.5	0.9	0.2	0.8	-0.9	-0.6	-0.7
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	0.3	0.0	-0.8	1.3	-0.5
Birth weight	0.8	1.7	4.8	-0.0	1.0	-2.2	-0.8	-1.4
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.1	-1.3	-0.5	-1.4	0.5	0.1
High blood pressure (siblings)	0.3	0.4	0.9	0.6	0.7	-0.5	-0.4	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.9	2.0	-1.4	-1.4	0.1	-0.5	0.2
Body fat percentage	0.2	0.9	3.3	0.5	1.0	-1.8	0.2	-0.3
Leg fat percentage (right)	0.6	2.2	7.3	-0.6	0.1	-2.7	0.9	-1.6
Arm fat-free mass (right)	2.5	12.9	22.0	-4.2	-4.3	-4.7	2.4	-0.8
Exposure to tobacco smoke outside home	1.2	1.6	3.2	-1.3	-1.0	-1.4	0.4	-1.8
Comparative body size at age 10	2.4	6.6	11.9	-2.7	-2.3	-3.4	2.9	-0.3
Number of full brothers	1.8	2.2	6.6	1.8	2.6	0.1	-0.5	0.9
Worry too long after embarrassment	0.2	0.3	0.9	0.3	0.5	-0.3	0.1	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	3.8	-1.9	-1.6	1.0	0.7	1.0
Wheeze or whistling in the chest in last year	0.7	1.3	3.9	2.0	1.6	-0.0	0.4	0.1
Number of children fathered	0.4	0.5	2.1	0.3	0.4	0.3	-0.2	1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	0.5	-0.0	0.3	-0.1	0.7
Age at first live birth	0.2	0.3	0.6	0.7	0.6	0.8	-0.1	-0.3
Pulse wave peak to peak time	0.2	0.3	0.6	0.4	0.3	0.8	0.6	-0.4
Health satisfaction	0.3	0.4	1.0	-1.0	-0.7	-0.3	0.5	-0.4
Shortness of breath walking on level ground	0.4	0.4	2.1	-0.3	-0.1	-0.3	-0.0	-1.4
Qualifications: College or University degree	0.7	2.3	7.7	0.1	-0.3	0.4	2.8	1.9
Eye problems/disorders: None of the above	1.5	1.7	5.5	2.3	1.3	-0.4	0.7	0.8
Mouth/teeth dental problems: Loose teeth	1.3	1.5	5.4	-1.1	-0.8	-0.4	0.5	-2.3
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.1	-0.3	-0.5	0.3	-0.5
Medication for pain relief, constipation, heartburn	1.7	3.0	4.8	2.2	2.1	0.2	0.9	2.2
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.6	-0.6	-0.6	-0.4	-0.7
Medication: Blood pressure	2.5	4.5	9.6	-2.8	-3.1	-1.3	0.3	-1.8
Angina (self-reported)	0.8	1.0	2.6	-1.1	-0.4	-0.3	-1.0	-1.6
Migraine (self-reported)	0.6	0.7	1.7	1.3	1.0	0.8	-0.2	-0.1
Medication: Ibuprofen	0.5	0.6	1.5	0.2	0.3	0.7	-1.2	-0.8
Medication: Allopurinol	0.9	1.3	2.9	-1.3	-0.9	0.1	1.7	-0.9
Medication: Omeprazole	0.5	0.7	1.4	-0.1	0.5	1.2	-1.0	-0.8
Medication: Seretide 50 evohaler	2.0	2.3	3.3	-1.3	-1.7	-1.6	1.8	-1.0
Mean time to correctly identify matches	1.1	2.2	8.1	-0.7	-1.3	2.8	-0.8	0.1
Heart disease (mother)	0.5	0.7	1.4	-1.2	-1.1	-0.8	-0.1	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.3	0.6	0.3	0.5	-1.8	-0.3
Whole body fat mass	0.5	2.1	8.3	-0.9	-0.3	-2.9	0.9	-0.6
Leg fat mass (right)	1.0	3.7	12.4	-1.4	-0.8	-3.5	1.4	-1.3
Arm predicted mass (right)	2.8	14.1	22.8	-4.5	-4.6	-4.8	2.5	-0.8
Pulse rate, automated reading	2.1	6.8	16.9	4.1	3.4	0.4	-0.6	2.2
Alcohol intake frequency.	0.4	0.9	1.8	1.2	1.3	-1.0	0.4	0.4
Comparative height size at age 10	0.5	2.7	6.5	-1.8	-1.9	0.0	0.4	2.5
Number of full sisters	1.2	1.4	2.9	1.6	1.7	0.6	-0.9	0.6
Suffer from ‘nerves’	0.4	0.6	1.6	-0.9	-0.3	-1.3	0.2	-0.5
Overall health rating	1.4	2.9	5.8	-1.8	-1.6	-0.9	2.4	-1.5
Chest pain or discomfort	2.7	3.8	7.8	-1.6	-2.0	-1.9	2.8	-1.1
Had major operations	0.6	0.7	2.0	0.6	0.8	-0.7	1.4	-0.0
Age at last live birth	0.9	1.3	2.0	1.4	1.3	1.3	0.6	0.9
Family relationship satisfaction	0.1	0.2	0.4	0.4	0.4	-0.4	0.6	-0.0
Leg pain on walking	1.0	1.2	3.3	-1.1	-0.9	-0.6	-0.6	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	3.8	-1.9	-0.6	-0.4	-0.3	-1.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.2	0.4	-0.3	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.2	0.2	0.1	0.8	-0.2	1.1
Medication: Aspirin	2.6	3.4	8.3	-2.9	-2.8	0.5	-1.0	-0.0
Supplements: Vitamin C	3.4	4.0	7.3	2.5	2.7	1.9	-0.6	1.6
Knee pain experienced in last month	0.6	0.9	2.6	-0.4	0.1	-0.6	-1.6	1.2
Hypertension (Self-reported)	1.4	3.8	9.5	-2.8	-3.1	-0.9	0.5	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.1	0.8	0.7	1.7	-1.8	-0.2
Illnesses of father: Heart disease	2.3	3.2	6.5	-2.2	-2.5	-0.6	1.8	-1.0
Illnesses of siblings: Diabetes	0.2	0.3	0.9	0.2	0.5	-0.9	0.0	-0.4
Smoking status: Previous	0.1	0.1	0.3	0.1	0.1	0.4	0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	6.7	-2.6	-2.4	-1.9	2.6	0.1
Whole body fat-free mass	1.8	10.3	16.8	-3.9	-3.9	-4.1	2.0	-0.1
Leg fat-free mass (right)	1.1	5.6	8.5	-2.9	-2.8	-2.9	1.8	0.2
Arm fat percentage (left)	0.3	1.4	5.5	0.0	0.7	-2.4	0.6	-0.6
Average weekly red wine intake	0.7	1.1	2.3	-1.1	-1.4	1.5	-0.0	-0.1
Handedness (chirality/laterality): Left-handed	1.1	1.4	1.9	-1.4	-1.3	1.1	-1.1	0.9
Mood swings	0.9	1.6	3.2	-1.8	-1.6	-0.1	0.5	-1.3
Loneliness, isolation	0.3	0.3	1.0	0.3	0.6	-0.5	-0.1	1.0
Long-standing illness, disability or infirmity	0.1	0.2	0.4	0.6	0.6	0.1	0.4	0.0
Ever had bowel cancer screening	1.8	2.1	6.8	1.0	0.3	-0.7	-1.4	2.6
Diabetes diagnosed by doctor	0.5	0.8	1.5	0.6	0.8	-0.4	1.2	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.9	-1.3	-1.3	0.1	0.2	-1.7
Friendships satisfaction	0.5	0.6	2.5	-0.3	0.5	-0.6	1.6	0.1
Qualifications: nursing, teaching	0.6	1.0	1.7	0.7	1.1	0.7	-1.3	-1.0
Commuting to job workplace: Walk	1.0	1.0	2.7	0.3	-0.0	1.5	-0.4	1.6
Eye problems/disorders: Cataract	2.1	2.4	6.9	-2.6	-1.9	-0.2	1.3	-0.4
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	4.8	-2.2	-2.0	-0.1	1.4	-1.2
Medication for cholesterol	0.3	0.5	0.9	-0.7	-0.9	-0.6	0.7	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.7	-1.2	-1.7	-0.1	1.2	-0.5
Back pain experienced in last month	0.8	1.1	1.8	-1.2	-1.4	-0.6	-0.9	-1.1
Mineral and other dietary supplements	0.4	0.6	1.4	-1.2	-0.9	0.2	0.8	0.0
Breast cancer (self-reported)	1.5	1.8	5.4	1.5	0.5	2.3	-0.7	0.9
Asthma (self-reported)	0.2	0.5	0.8	0.4	0.2	-0.8	0.9	-0.8
Osteoporosis (self-reported)	0.3	0.4	0.7	0.9	0.6	0.5	0.8	-0.4
Osteoarthritis (self-reported)	0.1	0.2	0.5	-0.1	0.0	-0.7	0.4	0.5
Medication: Aspirin	2.8	3.6	8.8	-2.9	-3.0	0.5	-0.7	-0.2
Medication: Gliclazide	1.0	1.1	2.0	1.4	1.3	1.3	-0.4	0.4
Illnesses of father: None of the above (group 1)	1.1	1.4	2.1	1.3	1.5	1.2	-1.2	-0.4
Smoking status: Current	0.8	1.3	2.9	0.9	1.4	1.7	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.7	-1.4	-1.1	-0.3	-1.6	-0.5
Whole body water mass	1.7	9.9	16.4	-3.9	-3.8	-4.0	1.9	0.0
Leg predicted mass (right)	1.1	5.7	8.5	-2.9	-2.9	-2.9	1.9	0.2
Arm fat mass (left)	0.6	2.6	9.4	-1.1	-0.5	-3.1	1.2	-0.8
Number of self-reported non-cancer illnesses	0.5	0.8	2.1	-0.5	-1.0	1.4	0.0	0.9
Average weekly champagne plus white wine intake	0.6	0.9	2.0	0.5	-0.1	1.0	1.4	1.0
Miserableness	0.6	1.1	2.7	-1.4	-0.8	-1.6	0.1	-0.5
Guilty feelings	0.9	1.4	2.3	-1.5	-1.5	-0.6	1.4	0.4
Wears glasses or contact lenses	1.3	1.5	5.4	-0.0	0.1	2.3	-1.3	0.6
Ever taken oral contraceptive pill	1.4	1.6	2.9	1.4	1.7	1.2	-0.1	1.4
Hearing aid user	0.3	0.3	0.9	1.0	0.3	0.1	0.7	-0.2
Mother’s age at death	0.9	1.1	2.2	-1.3	-1.5	0.6	-0.4	-1.0
Financial situation satisfaction	1.9	2.4	6.3	2.5	2.2	-0.4	0.3	0.8
Tinnitus: Yes, now most or all of the time	1.5	1.8	4.0	-1.8	-2.0	-0.6	-1.2	0.4
Commuting to job workplace: Public transport	1.0	1.2	3.9	-1.2	-2.0	0.3	0.6	-0.3
Eye problems/disorders: Glaucoma	0.8	1.0	2.3	-1.5	-1.3	0.4	-0.2	-0.9
Medication: Blood pressure	0.4	0.8	1.9	0.0	0.2	1.4	-0.5	1.3
Pain type(s) experienced in last month: Hip pain	0.7	0.8	1.7	-1.3	-1.3	-0.0	0.6	-0.6
Supplements: Fish oil (including cod liver oil)	2.6	3.4	5.1	2.0	1.6	1.4	-1.8	2.2
High cholesterol (Self-reported)	0.7	1.2	2.6	-1.5	-1.6	0.8	0.1	0.6
Medication: Bendroflumethiazide	0.6	0.9	2.5	0.5	0.9	0.5	-1.6	0.7
Medication: Paracetamol	0.7	1.0	4.0	0.5	0.7	-0.2	-0.6	-2.0
Medication: Lisinopril	0.2	0.3	0.7	-0.6	-0.2	-0.5	-0.2	-0.9
Medication: Atorvastatin	2.6	3.2	6.5	-2.5	-2.5	-0.9	0.7	-1.4
Illnesses of father: High blood pressure	0.8	1.0	1.6	-1.3	-0.9	-1.0	1.2	0.5
Alcohol drinker status: Never	1.1	1.4	3.8	1.9	1.2	1.2	0.4	0.4
Ever smoked	0.4	0.7	1.5	1.2	1.2	0.2	-0.7	-0.0
Basal metabolic rate	1.7	9.1	16.8	-3.6	-3.4	-4.1	2.0	-0.3
Leg fat percentage (left)	0.5	1.7	5.2	-0.7	0.1	-2.3	1.0	-1.4
Arm fat-free mass (left)	2.3	11.8	21.2	-4.1	-3.9	-4.6	2.3	-0.9
Number of operations (self-reported)	0.1	0.1	0.3	0.1	0.0	0.6	0.5	0.2
Average weekly beer plus cider intake	0.1	0.2	0.5	0.1	0.3	-0.7	0.5	-0.1
Irritability	0.5	0.8	2.7	-0.7	-0.4	-0.9	1.7	0.1
Risk taking	2.0	3.0	5.4	1.4	1.5	1.9	-2.3	1.2
Ever had prostate specific antigen (PSA) test	3.0	3.4	8.6	1.2	1.5	1.2	-1.9	2.9
Fractured/broken bones in last 5 years	1.0	1.2	4.5	0.7	0.7	-0.8	-2.1	0.2
Age started oral contraceptive pill	0.3	0.4	0.7	-0.5	-0.8	-0.6	0.8	0.4
Diastolic blood pressure, automated reading	3.3	10.1	13.1	-3.5	-3.6	-3.2	3.3	-2.0
Ever depressed for a whole week	0.3	0.3	1.0	-0.5	-0.1	-1.0	0.6	0.1
Unable to work because of sickness or disability	0.2	0.3	0.6	0.2	0.0	-0.8	0.5	0.7
Commuting to job workplace: Cycle	1.3	1.5	3.5	-0.5	-1.5	-1.2	1.9	0.3
Myopia	0.7	1.0	3.0	-0.5	0.1	-0.6	1.7	-1.1
Vascular/heart problems diagnosed by doctor	1.5	4.2	11.1	3.0	3.3	0.4	-0.6	0.6
Cholesterol lowering medication	0.5	0.8	1.3	-0.7	-0.6	1.1	-0.7	1.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	0.3	1.1	1.0	-1.0	-0.5
Pain experienced in last month	0.5	0.8	2.7	0.7	0.5	0.7	1.6	0.2
Supplements: Calcium	1.7	1.8	3.3	1.8	1.8	1.0	-0.8	1.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.4	-0.2	-0.1	-0.1	0.4	0.7
Heart attack/myocardial infarction (self-reported)	2.1	2.7	6.0	-2.4	-2.5	1.0	0.5	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	5.0	-0.0	-0.3	2.2	-0.1	0.9
Heart disease (siblings)	2.0	2.4	5.5	-2.4	-1.8	1.7	-0.3	-0.6
Alcohol drinker status: Previous	1.4	1.6	3.0	-1.1	-1.7	-1.7	0.9	0.5
Pack years of smoking	0.4	0.6	1.8	0.7	1.3	0.2	-0.4	0.6
Impedance of whole body	2.2	11.3	16.9	4.1	4.0	3.5	-3.0	1.4
Leg fat mass (left)	0.8	3.2	9.7	-1.5	-0.9	-3.1	1.4	-1.1
Arm predicted mass (left)	1.9	9.8	17.8	-3.7	-3.6	-4.2	2.0	-0.6