Hub : Genes

PRKAR1A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1190 0.0460 9.5e-03 0.055 NA 0.084 NA 0.079 5.3e-04 NA 2.1e-05 NA 3.9e-05
2 GTEx Artery Tibial 0.2489 0.0452 4.4e-10 0.219 NA 0.234 NA 0.230 4.5e-17 NA 2.9e-18 NA 5.9e-18
3 GTEx Testis 0.2720 0.0740 1.7e-04 0.118 NA 0.118 NA 0.146 6.4e-06 NA 6.7e-06 NA 5.3e-07
4 NTR Blood 0.0198 0.0083 7.3e-03 0.000 0.005 0.001 0.005 0.000 3.8e-01 0.0081 1.5e-01 0.0087 2.3e-01
5 TCGA Brain Lower Grade Glioma 0.0455 0.0258 7.6e-03 0.007 0.019 0.022 NA 0.017 5.0e-02 0.0029 1.5e-03 NA 4.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.0 1.6 6.9 -0.6 -0.7 -0.2 0.3 -2.6
Bipolar Disorder or Schizophrenia 0.7 1.7 7.3 0.1 -0.2 -1.1 -0.2 -2.7
Depressed Affect (Nagel 2018) 0.1 0.3 0.9 -0.3 -0.2 -0.9 0.6 0.1
Depression (Nagel 2018) 0.3 0.4 1.9 0.0 -0.1 -0.1 1.4 0.3
Intelligence (Savage-Jansen 2018) 0.9 2.7 6.2 0.9 1.5 1.7 1.2 2.5
Neuroticism (Nagel 2018) 0.1 0.1 0.3 0.5 0.6 0.0 -0.0 0.3
Schizophrenia (2018) 0.4 0.8 1.9 0.6 0.3 -1.2 -0.5 -1.4
Schizophrenia vs Biploar Disorder 1.6 2.1 4.5 2.1 1.6 -0.9 0.2 1.7
Worry (Nagel 2018) 0.5 1.0 1.5 1.1 1.2 1.2 -1.0 0.2
Alzheimer’s Disease (in mother) 0.7 0.8 2.8 -0.5 -0.6 -0.6 -0.4 -1.7
Alzheimer’s Disease (in father) 0.4 0.5 1.3 -0.6 -0.2 0.3 -0.8 1.1
Alzheimer’s Disease (including proxy) 0.6 0.9 1.3 -1.1 -1.1 -0.5 -1.0 -0.8
Crohns Disease (2017) 0.3 0.7 1.7 1.0 1.3 -0.5 -0.7 -0.3
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.0 0.0 0.0 -0.3 0.3
Ulcerative Colitis (UC) 0.4 0.7 1.2 -1.0 -1.1 0.7 -0.2 1.0
Major Depression (MDD) 0.8 1.0 3.5 0.6 0.8 1.9 -0.2 -0.6
Reaction Time 0.7 1.4 5.5 -0.5 -0.6 2.3 -0.2 0.9
Verbal and Numeric Reasoning (VNR) 1.0 2.5 4.1 1.2 2.0 1.6 0.7 1.9
Breast Cancer 2.9 7.1 11.9 -2.9 -1.9 -2.7 3.5 -2.0
Ovarian Cancer 0.5 0.6 2.4 -0.5 0.6 -0.1 -1.6 -0.4
Prostate Cancer 3.0 4.2 9.8 -2.7 -3.1 -1.8 0.2 -0.5
Age at First Birth 0.5 0.7 2.1 -0.2 -0.4 1.4 -1.0 0.7
Bipolar Disorder (2011) 0.1 0.1 0.1 0.3 -0.3 0.3 0.4 0.0
Body Mass Index (BMI) (2010) 0.5 0.7 1.7 -0.7 -1.0 -1.3 -0.0 -0.5
Coronary Artery Disease (CAD) 6.3 7.6 13.0 -3.6 -3.5 -0.5 2.1 -2.7
Crohns Disease (2012) 0.2 0.3 1.3 0.3 0.4 0.1 -0.2 -1.1
Mean Putamen Volume 0.4 0.4 1.0 -0.3 -0.5 0.7 -1.0 0.6
Fasting Glucose 1.3 1.5 4.6 1.5 2.1 0.4 -0.4 0.6
HbA1C 2.3 2.5 10.5 -0.9 -0.3 -1.0 -0.3 -3.2
HDL Cholesterol 2.3 3.8 6.9 1.9 1.4 0.3 -2.6 2.5
LDL Cholesterol 1.2 1.9 5.2 -2.0 -2.3 -0.5 0.2 -0.4
Lupus 0.7 1.0 3.5 -1.1 -1.9 0.1 -0.3 -0.5
Neuroticism (2016) 0.1 0.1 0.4 -0.5 0.2 -0.1 -0.0 -0.6
Primary Biliary Cirrhosis 0.3 0.4 1.9 0.2 0.2 -0.0 -1.4 0.4
Rheumatoid Arthritis 0.1 0.2 0.3 -0.6 -0.6 0.3 0.2 -0.5
Schizophrenia (2014) 0.5 1.0 2.8 0.9 0.5 -1.1 0.1 -1.7
Triglycerides 1.1 1.8 4.6 1.3 2.2 1.6 -0.2 0.2
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.4 -0.4 -0.1 -1.2 -0.1 0.1
Ulcerative Colitis 0.6 0.9 1.7 -0.4 -0.9 1.3 -0.7 1.2
Blood Eosinophil Count 0.1 0.5 1.3 -0.4 0.1 -1.1 0.0 -1.1
Blood Platelet Count 0.8 8.7 20.0 1.3 1.5 4.5 -4.0 -1.9
Blood Red Count 0.2 1.9 4.8 2.2 2.0 -0.6 0.3 -0.3
Blood White Count 0.3 2.2 3.4 1.5 1.4 1.2 -1.5 -1.8
Heel T-Score 0.3 2.2 8.0 0.3 1.1 -2.8 -1.3 0.2
BMI 0.7 3.9 10.9 -1.1 -0.6 -3.3 2.4 -1.2
Height 0.3 6.5 13.4 -3.5 -3.7 -1.1 -1.8 1.4
Waist Hip Ratio (WHR) 0.7 3.2 8.0 1.2 1.5 0.5 2.8 2.0
Systolic Blood Pressure 0.2 0.9 1.4 -0.8 -0.7 0.7 1.2 -1.2
Smoking Status 0.7 1.8 3.4 1.4 1.8 1.8 0.4 0.5
Allergy or Eczema 0.8 2.1 4.3 2.1 2.1 0.5 -0.7 1.2
Cardiovascular Disease 0.4 1.2 3.1 -1.5 -1.8 -0.4 0.2 -0.6
Hypothyroidism (self reported) 0.3 0.7 1.2 0.1 -0.3 -0.9 1.1 1.1
Respiratory disease 0.5 1.0 2.6 1.6 1.6 -0.1 0.2 0.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.9 0.3 0.3 -1.7 1.0 0.8
Lung FEV1/FVC ratio 0.4 1.9 7.7 -0.8 -1.0 -0.3 -2.8 -0.1
Lung FVC 0.1 0.6 1.3 0.3 0.5 1.0 -0.5 -1.1
Neuroticism 0.1 0.1 0.3 0.2 0.2 -0.5 0.5 -0.0
Chronotype (morning person) 0.6 1.3 3.0 -0.6 -0.4 -1.4 -0.9 -1.7
Hair Pigment 0.0 0.2 0.6 -0.3 -0.5 -0.4 0.7 0.5
Tanning 0.1 1.1 2.4 -1.1 -1.4 0.3 0.1 -1.5
Hand grip strength (left) 0.9 2.4 6.5 -1.6 -2.6 -0.7 -0.0 -1.6
Number of treatments/medications taken 0.5 0.9 1.9 -0.8 -1.2 0.1 -0.6 -1.4
Average weekly spirits intake 0.9 1.2 2.2 -1.4 -1.5 0.5 -0.2 1.2
Sensitivity / hurt feelings 0.2 0.3 0.9 -0.4 -1.0 -0.7 -0.0 0.3
Frequency of depressed mood in last 2 weeks 0.7 1.0 3.1 -0.3 -0.4 -0.1 1.3 1.8
Hearing difficulty/problems: Yes 1.7 2.5 6.9 0.4 0.0 2.4 -0.1 2.6
Relative age of first facial hair 0.4 0.9 2.4 -1.0 -0.7 0.7 -1.6 0.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.6 1.6 -1.0 -1.3 0.3 0.2 -0.3
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.8 -0.2 -0.5 0.2 -0.9 -0.9
Ever had hysterectomy (womb removed) 0.7 0.8 1.6 -0.9 -1.1 -0.2 -1.3 -0.5
Systolic blood pressure, automated reading 2.1 6.2 10.6 -2.2 -2.4 -2.6 3.3 -1.8
Eye problems/disorders: Diabetes related eye disease 1.4 1.5 4.1 -0.7 -0.4 1.5 0.6 2.0
Angina 0.8 1.1 2.2 -1.3 -0.8 -0.2 -0.9 -1.5
Medication for hormone replacement therapy 1.1 1.2 4.6 0.6 0.5 -0.8 -0.2 -2.2
Vitamin and mineral supplements 0.9 1.2 3.2 -1.6 -1.8 0.0 -0.3 -0.3
Supplements: Zinc 0.7 0.8 1.9 0.8 0.7 0.4 -0.8 1.4
Medication: Co-codamol 2.4 2.7 5.8 -2.3 -2.4 -0.7 1.4 0.2
Medication: Metformin 0.6 0.8 2.1 -0.9 -0.4 -0.5 1.5 -1.0
Diabetes (father) 0.8 1.0 2.6 0.9 0.7 -1.6 1.0 0.4
Diabetes (mother) 1.5 1.9 3.5 1.9 1.7 -1.3 -0.8 1.0
Severe depression (siblings) 1.7 1.9 3.6 1.7 1.9 1.2 -1.1 0.6
Pack years adult smoking proportion 0.3 0.4 1.5 0.6 1.2 -0.3 -0.3 0.2
Impedance of leg (right) 1.3 6.2 10.3 3.1 3.2 1.8 -2.7 0.5
Leg fat-free mass (left) 1.1 5.7 11.0 -2.7 -2.6 -3.3 1.9 0.2
Trunk fat percentage 0.2 0.9 2.1 0.8 1.3 -1.4 0.0 -0.3
Hand grip strength (right) 0.8 2.3 6.6 -1.4 -2.6 -0.9 0.7 -1.2
Townsend deprivation index at recruitment 0.4 0.5 1.0 0.2 0.6 0.6 -1.0 -0.8
Current tobacco smoking 0.7 1.2 2.2 1.0 1.5 1.4 -0.7 0.6
Average weekly fortified wine intake 0.1 0.2 0.4 0.2 0.5 0.2 -0.7 -0.1
Maternal smoking around birth 1.0 1.4 3.4 -1.9 -0.7 -0.9 1.1 -1.0
Fed-up feelings 0.6 1.2 4.5 -0.3 -0.5 -2.1 0.9 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.8 -0.6 -0.4 -1.2 1.9 -0.7
Relative age voice broke 1.0 1.6 2.7 -1.4 -1.2 -0.2 -1.3 -1.7
Taking other prescription medications 0.4 0.7 2.2 -0.2 -0.4 1.5 -0.7 0.7
Age when periods started (menarche) 0.8 1.9 8.8 -0.3 0.3 -0.1 -3.0 -0.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.8 -0.7 -0.9 0.0 -0.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.9 1.6 0.4 1.2 -1.2 -1.1 -0.1
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 1.8 -0.7 -0.9 -1.2 0.1 1.3
Qualifications: CSEs or equivalent 1.1 1.5 2.8 1.3 1.5 -1.7 -0.1 -1.0
Serious illness, injury or assault to yourself 0.3 0.4 1.8 0.2 -0.0 1.4 -0.4 -0.2
High blood pressure 1.1 3.1 7.7 -2.5 -2.8 -0.8 0.8 -0.5
Hayfever, allergic rhinitis or eczema 1.6 3.5 6.5 2.4 2.5 0.7 -1.0 2.0
Multivitamins +/- minerals 0.6 0.7 1.5 0.7 0.9 -1.2 0.6 0.6
Stomach or abdominal pain in last month 1.9 2.4 4.0 0.7 1.5 1.8 -2.0 1.4
Supplements: Glucosamine 0.6 0.8 2.8 0.2 0.7 0.5 -1.7 -0.6
Diverticular disease/diverticulitis (self-reported) 0.9 1.1 3.5 0.7 0.9 0.7 -1.9 0.4
Medication: Atenolol 1.0 1.3 2.2 -1.4 -1.5 0.2 -1.0 1.2
Medication: Levothyroxine sodium 0.2 0.4 1.3 0.1 -0.1 -0.2 1.2 0.8
Sitting height 0.6 4.6 9.5 -3.1 -2.7 -2.5 0.1 0.2
Chronic bronchitis/emphysema (father) 1.0 1.2 4.5 0.7 0.8 0.5 0.1 2.1
High blood pressure (mother) 1.0 1.4 5.6 -0.8 -0.8 -0.6 -0.0 -2.4
Body mass index (BMI) 1.0 4.5 12.3 -1.7 -1.2 -3.5 1.9 -1.4
Impedance of leg (left) 1.2 5.8 8.4 2.8 2.9 2.4 -2.6 0.7
Leg predicted mass (left) 1.0 5.6 11.0 -2.7 -2.5 -3.3 1.8 0.2
Trunk fat mass 0.3 1.3 6.0 -0.4 0.0 -2.4 0.5 -0.4
Waist circumference 0.8 2.8 8.2 -1.1 -0.5 -2.9 2.1 -0.2
Number of incorrect matches in round 0.2 0.3 1.0 -0.5 -0.4 0.2 0.0 -1.0
Past tobacco smoking 0.2 0.5 0.8 -0.8 -0.8 -0.9 0.4 0.1
Alcohol usually taken with meals 0.8 1.3 3.9 -1.3 -2.0 0.1 0.8 -0.5
Nervous feelings 0.2 0.5 1.9 0.3 0.4 0.3 -1.4 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 1.8 -1.0 -1.1 -0.5 1.1 1.4
Hearing difficulty/problems with background noise 0.2 0.3 1.0 -0.5 -0.5 1.0 -0.1 0.2
Hair/balding pattern: Pattern 2 1.3 1.7 3.4 -1.1 -1.9 -0.9 0.1 -1.7
Had menopause 0.3 0.4 0.7 -0.3 -0.8 -0.6 0.8 -0.0
Had other major operations 0.5 0.6 1.9 0.5 0.5 1.4 -0.6 -0.3
Forced vital capacity (FVC) 0.1 0.5 1.3 -1.1 -1.0 0.6 -0.4 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 0.9 0.4 0.8 -0.3 -1.0 0.2
Ever unenthusiastic/disinterested for a whole week 0.1 0.1 0.4 -0.6 0.0 -0.5 -0.2 0.0
Qualifications: None of the above 0.4 0.8 2.1 0.2 -0.4 -0.9 -1.0 -1.4
Financial difficulties in last 2 years 0.6 0.8 3.0 0.4 -0.2 -1.7 0.8 0.4
Mouth/teeth dental problems 2.9 4.4 10.0 3.2 2.3 -0.1 -2.0 1.8
Heart attack 2.1 2.6 5.9 -2.2 -2.4 0.6 0.8 -1.2
Allergy 1.3 3.0 5.2 -2.3 -2.2 -1.1 0.5 -1.8
Pain all over the body in last month 0.3 0.3 0.7 0.1 -0.0 -0.8 0.8 -0.6
Diabetes (self-reported) 0.7 1.0 3.1 0.8 0.9 -0.2 0.7 1.8
Hayfever/allergic rhinitis (self-reported) 1.1 1.5 3.8 1.4 2.0 0.8 -0.9 0.7
Medication: Ramipril 2.5 3.2 7.4 -2.7 -2.7 0.7 -0.3 -1.0
Medication: Simvastatin 0.4 0.6 1.6 0.1 -0.2 1.2 -0.4 1.2
Fluid intelligence score 0.5 1.0 3.8 -0.5 -0.3 0.1 1.9 0.9
Illnesses of siblings 0.4 0.6 1.8 0.3 0.1 -0.4 1.3 0.9
Neuroticism score 0.3 0.6 1.2 -0.9 -0.5 -1.1 0.8 -0.6
Weight 1.1 5.2 13.0 -2.4 -2.2 -3.6 1.5 -0.5
Impedance of arm (right) 3.6 17.0 26.4 5.0 5.1 4.1 -3.4 2.2
Arm fat percentage (right) 0.3 1.2 4.7 0.2 0.9 -2.2 0.6 -0.5
Trunk fat-free mass 2.3 13.2 20.8 -4.6 -4.6 -4.5 2.1 -0.4
Hip circumference 0.8 3.6 12.3 -1.8 -1.2 -3.5 0.6 -0.8
Time employed in main current job 2.8 3.2 5.7 1.3 1.7 2.2 -2.4 0.7
Alcohol intake versus 10 years previously 0.7 1.1 2.2 1.2 1.5 -0.8 0.4 -1.1
Father’s age at death 0.5 0.7 2.2 -0.8 -0.3 -0.0 -1.5 -0.6
Worrier / anxious feelings 0.3 0.5 1.9 0.3 0.2 1.4 -0.8 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 0.9 0.4 0.7 0.5 1.0 0.7
Falls in the last year 0.6 0.8 1.7 -0.9 -1.3 -0.7 -0.1 -0.9
Hair/balding pattern: Pattern 3 0.7 1.1 4.9 -0.3 -0.3 0.5 -0.3 2.2
Number of live births 2.0 2.8 6.5 -1.6 -1.6 -1.4 2.5 0.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.0 -0.8 -0.9 0.2 -1.4 -0.6
Pulse rate 0.7 1.2 1.7 1.1 1.3 0.8 -0.8 1.3
Happiness 1.5 1.9 3.8 1.3 1.9 1.4 0.3 1.4
Noisy workplace 0.9 1.2 2.6 1.6 0.7 0.1 -1.5 0.7
Qualifications: A levels/AS levels or equivalent 1.0 2.1 3.9 1.1 1.3 2.0 2.0 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.9 -0.9 -0.2 -0.3 0.2 0.6
Mouth/teeth dental problems: Dentures 2.0 3.3 6.0 -2.4 -2.1 -1.4 0.9 -1.8
Asthma 0.2 0.4 0.8 0.5 0.4 -0.7 0.9 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 2.3 0.2 0.1 -0.1 -1.5 -1.1
Medication: Cholesterol lowering 1.8 2.7 6.2 -2.2 -2.5 -0.2 1.1 -1.0
Depression (self-reported) 0.7 0.8 2.1 1.0 0.5 0.6 0.6 1.4
Medication: Lansoprazole 1.1 1.2 2.4 0.4 1.0 0.7 -1.4 1.5
Prospective memory result 0.4 0.5 1.6 0.6 0.3 0.4 -1.3 -0.5
Lung cancer (father) 0.8 0.9 1.7 0.6 1.3 0.9 -0.9 0.8
Illnesses of mother 0.7 0.9 2.3 0.8 0.7 0.6 0.9 1.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.4 3.1 -1.7 -1.8 -0.3 -1.0 -0.5
Pulse wave Arterial Stiffness index 0.4 0.5 0.9 -0.8 -0.8 -0.9 -0.3 0.5
Impedance of arm (left) 3.5 16.2 23.6 4.9 4.8 4.1 -3.5 2.4
Arm fat mass (right) 0.6 2.6 9.2 -1.2 -0.5 -3.0 1.3 -0.7
Trunk predicted mass 2.3 13.1 20.6 -4.5 -4.5 -4.5 2.1 -0.4
Standing height 0.3 3.0 5.8 -2.1 -2.4 -0.7 -0.7 1.9
Length of working week for main job 1.0 1.1 2.3 1.2 1.2 0.3 0.1 1.5
Exposure to tobacco smoke at home 0.7 0.8 1.3 1.1 1.0 -0.5 -0.8 -0.7
Breastfed as a baby 2.8 3.5 7.2 1.2 0.8 2.3 -1.8 2.7
Tense / ‘highly strung’ 0.4 0.7 1.7 -0.5 -0.6 0.2 1.3 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.2 -1.5 -0.9 -1.3 0.1 -1.2
Hair/balding pattern: Pattern 4 1.0 2.4 4.8 1.6 2.2 1.4 -1.1 1.2
Birth weight of first child 0.3 0.6 1.5 0.8 1.2 -0.5 -0.4 -0.7
Peak expiratory flow (PEF) 0.8 1.9 4.1 -2.0 -1.9 -0.5 -0.6 -1.1
Pulse wave reflection index 1.1 1.4 2.1 -1.4 -1.5 -1.3 0.4 -0.9
Ever highly irritable/argumentative for 2 days 1.9 2.2 4.6 -1.8 -1.4 -2.1 1.0 -0.6
Loud music exposure frequency 0.8 0.9 1.8 0.9 1.4 -0.4 -1.3 -0.0
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.3 -0.0 0.3 1.1 0.2 0.1
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.5 0.9 1.0 1.2 -0.3 1.1
Blood clot in the leg (DVT) 0.9 1.1 4.8 -0.2 -0.4 2.2 -0.2 0.7
Medication: Paracetamol 0.8 1.3 5.3 -0.0 0.1 -0.9 -0.7 -2.3
Headache pain in last month 1.0 1.8 4.2 1.5 1.5 -0.2 -2.1 -0.3
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 4.3 1.7 2.1 0.2 -0.1 0.8
Glaucoma (self-reported) 1.8 2.1 3.0 -1.7 -1.7 1.1 -1.0 -1.5
Gout (self-reported) 0.4 0.5 0.9 -0.8 -0.4 0.9 0.8 0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 1.5 0.3 -0.3 -0.7 0.8 1.2
Medication: Amlodipine 0.4 0.5 0.9 0.2 0.8 -0.9 -0.6 -0.7
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 0.3 0.0 -0.8 1.3 -0.5
Birth weight 0.8 1.7 4.8 -0.0 1.0 -2.2 -0.8 -1.4
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.1 -1.3 -0.5 -1.4 0.5 0.1
High blood pressure (siblings) 0.3 0.4 0.9 0.6 0.7 -0.5 -0.4 -0.9
Forced vital capacity (FVC), Best measure 0.2 0.9 2.0 -1.4 -1.4 0.1 -0.5 0.2
Body fat percentage 0.2 0.9 3.3 0.5 1.0 -1.8 0.2 -0.3
Leg fat percentage (right) 0.6 2.2 7.3 -0.6 0.1 -2.7 0.9 -1.6
Arm fat-free mass (right) 2.5 12.9 22.0 -4.2 -4.3 -4.7 2.4 -0.8
Exposure to tobacco smoke outside home 1.2 1.6 3.2 -1.3 -1.0 -1.4 0.4 -1.8
Comparative body size at age 10 2.4 6.6 11.9 -2.7 -2.3 -3.4 2.9 -0.3
Number of full brothers 1.8 2.2 6.6 1.8 2.6 0.1 -0.5 0.9
Worry too long after embarrassment 0.2 0.3 0.9 0.3 0.5 -0.3 0.1 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 3.8 -1.9 -1.6 1.0 0.7 1.0
Wheeze or whistling in the chest in last year 0.7 1.3 3.9 2.0 1.6 -0.0 0.4 0.1
Number of children fathered 0.4 0.5 2.1 0.3 0.4 0.3 -0.2 1.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.5 0.5 -0.0 0.3 -0.1 0.7
Age at first live birth 0.2 0.3 0.6 0.7 0.6 0.8 -0.1 -0.3
Pulse wave peak to peak time 0.2 0.3 0.6 0.4 0.3 0.8 0.6 -0.4
Health satisfaction 0.3 0.4 1.0 -1.0 -0.7 -0.3 0.5 -0.4
Shortness of breath walking on level ground 0.4 0.4 2.1 -0.3 -0.1 -0.3 -0.0 -1.4
Qualifications: College or University degree 0.7 2.3 7.7 0.1 -0.3 0.4 2.8 1.9
Eye problems/disorders: None of the above 1.5 1.7 5.5 2.3 1.3 -0.4 0.7 0.8
Mouth/teeth dental problems: Loose teeth 1.3 1.5 5.4 -1.1 -0.8 -0.4 0.5 -2.3
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.1 -0.3 -0.5 0.3 -0.5
Medication for pain relief, constipation, heartburn 1.7 3.0 4.8 2.2 2.1 0.2 0.9 2.2
Neck or shoulder pain in last month 0.2 0.3 0.6 -0.6 -0.6 -0.6 -0.4 -0.7
Medication: Blood pressure 2.5 4.5 9.6 -2.8 -3.1 -1.3 0.3 -1.8
Angina (self-reported) 0.8 1.0 2.6 -1.1 -0.4 -0.3 -1.0 -1.6
Migraine (self-reported) 0.6 0.7 1.7 1.3 1.0 0.8 -0.2 -0.1
Medication: Ibuprofen 0.5 0.6 1.5 0.2 0.3 0.7 -1.2 -0.8
Medication: Allopurinol 0.9 1.3 2.9 -1.3 -0.9 0.1 1.7 -0.9
Medication: Omeprazole 0.5 0.7 1.4 -0.1 0.5 1.2 -1.0 -0.8
Medication: Seretide 50 evohaler 2.0 2.3 3.3 -1.3 -1.7 -1.6 1.8 -1.0
Mean time to correctly identify matches 1.1 2.2 8.1 -0.7 -1.3 2.8 -0.8 0.1
Heart disease (mother) 0.5 0.7 1.4 -1.2 -1.1 -0.8 -0.1 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.3 0.6 0.3 0.5 -1.8 -0.3
Whole body fat mass 0.5 2.1 8.3 -0.9 -0.3 -2.9 0.9 -0.6
Leg fat mass (right) 1.0 3.7 12.4 -1.4 -0.8 -3.5 1.4 -1.3
Arm predicted mass (right) 2.8 14.1 22.8 -4.5 -4.6 -4.8 2.5 -0.8
Pulse rate, automated reading 2.1 6.8 16.9 4.1 3.4 0.4 -0.6 2.2
Alcohol intake frequency. 0.4 0.9 1.8 1.2 1.3 -1.0 0.4 0.4
Comparative height size at age 10 0.5 2.7 6.5 -1.8 -1.9 0.0 0.4 2.5
Number of full sisters 1.2 1.4 2.9 1.6 1.7 0.6 -0.9 0.6
Suffer from ‘nerves’ 0.4 0.6 1.6 -0.9 -0.3 -1.3 0.2 -0.5
Overall health rating 1.4 2.9 5.8 -1.8 -1.6 -0.9 2.4 -1.5
Chest pain or discomfort 2.7 3.8 7.8 -1.6 -2.0 -1.9 2.8 -1.1
Had major operations 0.6 0.7 2.0 0.6 0.8 -0.7 1.4 -0.0
Age at last live birth 0.9 1.3 2.0 1.4 1.3 1.3 0.6 0.9
Family relationship satisfaction 0.1 0.2 0.4 0.4 0.4 -0.4 0.6 -0.0
Leg pain on walking 1.0 1.2 3.3 -1.1 -0.9 -0.6 -0.6 -1.8
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 3.8 -1.9 -0.6 -0.4 -0.3 -1.3
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.2 -0.2 0.4 -0.3 0.1 0.1
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 1.2 0.2 0.1 0.8 -0.2 1.1
Medication: Aspirin 2.6 3.4 8.3 -2.9 -2.8 0.5 -1.0 -0.0
Supplements: Vitamin C 3.4 4.0 7.3 2.5 2.7 1.9 -0.6 1.6
Knee pain experienced in last month 0.6 0.9 2.6 -0.4 0.1 -0.6 -1.6 1.2
Hypertension (Self-reported) 1.4 3.8 9.5 -2.8 -3.1 -0.9 0.5 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.2 1.4 3.1 0.8 0.7 1.7 -1.8 -0.2
Illnesses of father: Heart disease 2.3 3.2 6.5 -2.2 -2.5 -0.6 1.8 -1.0
Illnesses of siblings: Diabetes 0.2 0.3 0.9 0.2 0.5 -0.9 0.0 -0.4
Smoking status: Previous 0.1 0.1 0.3 0.1 0.1 0.4 0.5 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.5 6.7 -2.6 -2.4 -1.9 2.6 0.1
Whole body fat-free mass 1.8 10.3 16.8 -3.9 -3.9 -4.1 2.0 -0.1
Leg fat-free mass (right) 1.1 5.6 8.5 -2.9 -2.8 -2.9 1.8 0.2
Arm fat percentage (left) 0.3 1.4 5.5 0.0 0.7 -2.4 0.6 -0.6
Average weekly red wine intake 0.7 1.1 2.3 -1.1 -1.4 1.5 -0.0 -0.1
Handedness (chirality/laterality): Left-handed 1.1 1.4 1.9 -1.4 -1.3 1.1 -1.1 0.9
Mood swings 0.9 1.6 3.2 -1.8 -1.6 -0.1 0.5 -1.3
Loneliness, isolation 0.3 0.3 1.0 0.3 0.6 -0.5 -0.1 1.0
Long-standing illness, disability or infirmity 0.1 0.2 0.4 0.6 0.6 0.1 0.4 0.0
Ever had bowel cancer screening 1.8 2.1 6.8 1.0 0.3 -0.7 -1.4 2.6
Diabetes diagnosed by doctor 0.5 0.8 1.5 0.6 0.8 -0.4 1.2 1.2
Ever had stillbirth, spontaneous miscarriage or termination 1.2 1.3 2.9 -1.3 -1.3 0.1 0.2 -1.7
Friendships satisfaction 0.5 0.6 2.5 -0.3 0.5 -0.6 1.6 0.1
Qualifications: nursing, teaching 0.6 1.0 1.7 0.7 1.1 0.7 -1.3 -1.0
Commuting to job workplace: Walk 1.0 1.0 2.7 0.3 -0.0 1.5 -0.4 1.6
Eye problems/disorders: Cataract 2.1 2.4 6.9 -2.6 -1.9 -0.2 1.3 -0.4
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 4.8 -2.2 -2.0 -0.1 1.4 -1.2
Medication for cholesterol 0.3 0.5 0.9 -0.7 -0.9 -0.6 0.7 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.7 -1.2 -1.7 -0.1 1.2 -0.5
Back pain experienced in last month 0.8 1.1 1.8 -1.2 -1.4 -0.6 -0.9 -1.1
Mineral and other dietary supplements 0.4 0.6 1.4 -1.2 -0.9 0.2 0.8 0.0
Breast cancer (self-reported) 1.5 1.8 5.4 1.5 0.5 2.3 -0.7 0.9
Asthma (self-reported) 0.2 0.5 0.8 0.4 0.2 -0.8 0.9 -0.8
Osteoporosis (self-reported) 0.3 0.4 0.7 0.9 0.6 0.5 0.8 -0.4
Osteoarthritis (self-reported) 0.1 0.2 0.5 -0.1 0.0 -0.7 0.4 0.5
Medication: Aspirin 2.8 3.6 8.8 -2.9 -3.0 0.5 -0.7 -0.2
Medication: Gliclazide 1.0 1.1 2.0 1.4 1.3 1.3 -0.4 0.4
Illnesses of father: None of the above (group 1) 1.1 1.4 2.1 1.3 1.5 1.2 -1.2 -0.4
Smoking status: Current 0.8 1.3 2.9 0.9 1.4 1.7 -0.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.7 -1.4 -1.1 -0.3 -1.6 -0.5
Whole body water mass 1.7 9.9 16.4 -3.9 -3.8 -4.0 1.9 0.0
Leg predicted mass (right) 1.1 5.7 8.5 -2.9 -2.9 -2.9 1.9 0.2
Arm fat mass (left) 0.6 2.6 9.4 -1.1 -0.5 -3.1 1.2 -0.8
Number of self-reported non-cancer illnesses 0.5 0.8 2.1 -0.5 -1.0 1.4 0.0 0.9
Average weekly champagne plus white wine intake 0.6 0.9 2.0 0.5 -0.1 1.0 1.4 1.0
Miserableness 0.6 1.1 2.7 -1.4 -0.8 -1.6 0.1 -0.5
Guilty feelings 0.9 1.4 2.3 -1.5 -1.5 -0.6 1.4 0.4
Wears glasses or contact lenses 1.3 1.5 5.4 -0.0 0.1 2.3 -1.3 0.6
Ever taken oral contraceptive pill 1.4 1.6 2.9 1.4 1.7 1.2 -0.1 1.4
Hearing aid user 0.3 0.3 0.9 1.0 0.3 0.1 0.7 -0.2
Mother’s age at death 0.9 1.1 2.2 -1.3 -1.5 0.6 -0.4 -1.0
Financial situation satisfaction 1.9 2.4 6.3 2.5 2.2 -0.4 0.3 0.8
Tinnitus: Yes, now most or all of the time 1.5 1.8 4.0 -1.8 -2.0 -0.6 -1.2 0.4
Commuting to job workplace: Public transport 1.0 1.2 3.9 -1.2 -2.0 0.3 0.6 -0.3
Eye problems/disorders: Glaucoma 0.8 1.0 2.3 -1.5 -1.3 0.4 -0.2 -0.9
Medication: Blood pressure 0.4 0.8 1.9 0.0 0.2 1.4 -0.5 1.3
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.7 -1.3 -1.3 -0.0 0.6 -0.6
Supplements: Fish oil (including cod liver oil) 2.6 3.4 5.1 2.0 1.6 1.4 -1.8 2.2
High cholesterol (Self-reported) 0.7 1.2 2.6 -1.5 -1.6 0.8 0.1 0.6
Medication: Bendroflumethiazide 0.6 0.9 2.5 0.5 0.9 0.5 -1.6 0.7
Medication: Paracetamol 0.7 1.0 4.0 0.5 0.7 -0.2 -0.6 -2.0
Medication: Lisinopril 0.2 0.3 0.7 -0.6 -0.2 -0.5 -0.2 -0.9
Medication: Atorvastatin 2.6 3.2 6.5 -2.5 -2.5 -0.9 0.7 -1.4
Illnesses of father: High blood pressure 0.8 1.0 1.6 -1.3 -0.9 -1.0 1.2 0.5
Alcohol drinker status: Never 1.1 1.4 3.8 1.9 1.2 1.2 0.4 0.4
Ever smoked 0.4 0.7 1.5 1.2 1.2 0.2 -0.7 -0.0
Basal metabolic rate 1.7 9.1 16.8 -3.6 -3.4 -4.1 2.0 -0.3
Leg fat percentage (left) 0.5 1.7 5.2 -0.7 0.1 -2.3 1.0 -1.4
Arm fat-free mass (left) 2.3 11.8 21.2 -4.1 -3.9 -4.6 2.3 -0.9
Number of operations (self-reported) 0.1 0.1 0.3 0.1 0.0 0.6 0.5 0.2
Average weekly beer plus cider intake 0.1 0.2 0.5 0.1 0.3 -0.7 0.5 -0.1
Irritability 0.5 0.8 2.7 -0.7 -0.4 -0.9 1.7 0.1
Risk taking 2.0 3.0 5.4 1.4 1.5 1.9 -2.3 1.2
Ever had prostate specific antigen (PSA) test 3.0 3.4 8.6 1.2 1.5 1.2 -1.9 2.9
Fractured/broken bones in last 5 years 1.0 1.2 4.5 0.7 0.7 -0.8 -2.1 0.2
Age started oral contraceptive pill 0.3 0.4 0.7 -0.5 -0.8 -0.6 0.8 0.4
Diastolic blood pressure, automated reading 3.3 10.1 13.1 -3.5 -3.6 -3.2 3.3 -2.0
Ever depressed for a whole week 0.3 0.3 1.0 -0.5 -0.1 -1.0 0.6 0.1
Unable to work because of sickness or disability 0.2 0.3 0.6 0.2 0.0 -0.8 0.5 0.7
Commuting to job workplace: Cycle 1.3 1.5 3.5 -0.5 -1.5 -1.2 1.9 0.3
Myopia 0.7 1.0 3.0 -0.5 0.1 -0.6 1.7 -1.1
Vascular/heart problems diagnosed by doctor 1.5 4.2 11.1 3.0 3.3 0.4 -0.6 0.6
Cholesterol lowering medication 0.5 0.8 1.3 -0.7 -0.6 1.1 -0.7 1.1
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.3 0.3 1.1 1.0 -1.0 -0.5
Pain experienced in last month 0.5 0.8 2.7 0.7 0.5 0.7 1.6 0.2
Supplements: Calcium 1.7 1.8 3.3 1.8 1.8 1.0 -0.8 1.0
Basal cell carcinoma (self-reported) 0.1 0.1 0.4 -0.2 -0.1 -0.1 0.4 0.7
Heart attack/myocardial infarction (self-reported) 2.1 2.7 6.0 -2.4 -2.5 1.0 0.5 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 5.0 -0.0 -0.3 2.2 -0.1 0.9
Heart disease (siblings) 2.0 2.4 5.5 -2.4 -1.8 1.7 -0.3 -0.6
Alcohol drinker status: Previous 1.4 1.6 3.0 -1.1 -1.7 -1.7 0.9 0.5
Pack years of smoking 0.4 0.6 1.8 0.7 1.3 0.2 -0.4 0.6
Impedance of whole body 2.2 11.3 16.9 4.1 4.0 3.5 -3.0 1.4
Leg fat mass (left) 0.8 3.2 9.7 -1.5 -0.9 -3.1 1.4 -1.1
Arm predicted mass (left) 1.9 9.8 17.8 -3.7 -3.6 -4.2 2.0 -0.6