TWAS hub - PRKG2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1380	0.0450	0.00013	0.026	0.043	0.043	0.05	0.032	3.8e-04	5.4e-06	5.0e-06	1e-06	8.4e-05
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0351	0.0200	0.00510	0.002	0.028	0.029	NA	0.023	1.9e-01	3.7e-04	2.8e-04	NA	1.2e-03
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0394	0.0186	0.00018	0.042	0.032	0.029	NA	0.039	1.4e-05	1.4e-04	3.0e-04	NA	3.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Friendships satisfaction	4.7	5.8	10.1	-3.2	-1.0	-2.6
Pulse rate	3.5	5.9	13.6	-0.3	-3.7	-2.0
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	6.0	0.4	-2.4	-2.4
Medication for hormone replacement therapy	2.9	3.3	7.8	2.8	0.4	1.4
Medication: Co-codamol	2.6	3.0	6.8	-2.6	1.1	1.1
Noisy workplace	2.6	3.2	8.1	-0.2	-2.9	-1.2
Height	2.5	48.0	130.0	-11.4	3.6	-1.0
Blood clot in the leg (DVT)	2.5	3.2	4.6	-1.0	-2.1	-2.0
Family relationship satisfaction	2.4	3.0	7.3	-2.7	0.6	-1.1
Commuting to job workplace: Car/motor vehicle	2.3	2.7	6.6	1.1	0.3	2.6
Had other major operations	2.2	2.7	4.3	-1.8	-0.8	-2.1
Maternal smoking around birth	2.1	3.0	4.1	-1.6	-2.0	-1.5
Risk taking	2.1	3.1	6.1	0.2	1.8	2.5
Deep venous thrombosis (DVT) (self-reported)	2.1	2.6	3.8	-1.0	-1.8	-1.9
Mouth/teeth dental problems: Dentures	2.0	3.3	9.4	0.7	-3.1	0.2
Standing height	2.0	19.5	48.6	-7.0	3.1	0.6
Supplements: Zinc	1.8	2.0	4.7	-2.2	1.0	0.4
Supplements: Glucosamine	1.8	2.4	3.6	0.1	-1.9	-1.9
Comparative body size at age 10	1.8	5.0	13.2	3.6	0.7	1.1
Health satisfaction	1.8	2.3	3.2	-0.7	1.8	1.8
Heart disease (siblings)	1.8	2.3	3.8	1.5	0.9	1.9
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.5	1.9	0.6	1.6
Illness, injury, bereavement, stress in last 2 years	1.6	1.9	2.6	-0.9	-1.5	-1.6
Mother’s age at death	1.6	2.0	5.7	2.4	-0.5	0.4
Mouth/teeth dental problems	1.5	2.3	5.2	-1.1	2.3	0.6
Osteoarthritis (self-reported)	1.5	2.0	3.3	-0.9	-1.8	-1.4
Diabetes (mother)	1.4	1.8	3.0	0.4	1.5	1.7
Average weekly fortified wine intake	1.4	1.7	4.0	-2.0	0.1	-1.0
Pain all over the body in last month	1.4	1.5	3.0	-0.5	1.1	1.7
Pulse rate, automated reading	1.4	4.5	12.6	0.1	-3.6	-1.0
Comparative height size at age 10	1.4	8.0	20.7	-4.5	1.8	-0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.1	1.1	0.1	1.8
Impedance of leg (left)	1.3	6.1	9.3	-3.0	2.5	1.6
Worry too long after embarrassment	1.3	2.1	3.4	-0.1	-1.7	-1.8
Smoking status: Previous	1.3	2.0	4.7	2.2	0.1	1.1
Basal cell carcinoma (self-reported)	1.3	1.5	3.3	-1.8	-0.4	-1.0
Medication: Levothyroxine sodium	1.2	2.0	4.7	-1.1	-2.2	0.1
Sitting height	1.2	8.4	21.0	-4.6	2.1	-0.2
Body mass index (BMI)	1.2	5.1	11.7	0.7	-3.4	-1.7
Forced vital capacity (FVC)	1.2	4.5	10.8	-0.3	3.3	1.6
Father’s age at death	1.2	1.7	3.4	1.8	0.9	0.9
Hair/balding pattern: Pattern 4	1.2	3.0	4.0	2.0	2.0	1.0
Gout (self-reported)	1.2	1.7	3.8	-0.8	-0.6	2.0
Medication: Amlodipine	1.2	1.7	2.6	-1.6	0.3	-1.5
Overall health rating	1.2	2.5	5.1	-2.2	-0.0	1.5
Age at last live birth	1.2	1.7	2.3	-1.4	1.5	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	2.5	-0.4	-1.2	-1.6
Alcohol drinker status: Never	1.2	1.4	2.4	-0.8	-1.2	-1.5
Age started oral contraceptive pill	1.2	1.5	3.1	1.8	-0.3	1.1
Trunk fat mass	1.1	4.6	8.0	-2.8	-2.0	-1.4
Hair/balding pattern: Pattern 2	1.1	1.4	3.7	-1.9	-0.4	-0.5
Pulse wave Arterial Stiffness index	1.1	1.2	3.1	-0.0	0.8	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.8	2.2	-0.5	-0.0
Forced vital capacity (FVC), Best measure	1.1	4.0	8.9	-0.3	3.0	1.7
Pulse wave peak to peak time	1.1	1.3	3.1	-0.8	-0.5	-1.8
Chest pain or discomfort	1.1	1.5	2.1	-1.4	-0.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	3.8	-1.9	1.5	1.0
Medication for cholesterol	1.1	1.7	3.2	-1.2	-0.7	-1.8
Alcohol drinker status: Previous	1.1	1.3	2.3	-1.2	-0.0	-1.5
Intelligence (Savage-Jansen 2018)	1.0	3.0	5.8	-1.3	-1.2	-2.4
Breast Cancer	1.0	2.5	5.9	-0.6	1.1	2.4
Schizophrenia (2014)	1.0	2.3	3.7	-1.7	1.9	-0.5
Ulcerative Colitis	1.0	1.4	2.2	-0.6	-1.3	-1.5
Cardiovascular Disease	1.0	3.4	7.4	0.2	1.7	2.7
Lung FVC	1.0	5.2	10.2	3.2	1.5	1.7
Trunk fat percentage	1.0	4.1	5.2	-2.3	-2.3	-1.4
Relative age voice broke	1.0	1.5	4.1	2.0	-0.7	-0.2
Alcohol usually taken with meals	1.0	1.5	2.4	1.5	1.3	0.7
Hair/balding pattern: Pattern 3	1.0	1.5	4.0	2.0	0.7	0.4
Medication: Cholesterol lowering	1.0	1.5	1.6	-1.3	1.3	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	8.1	-0.9	2.9	0.9
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.3	1.8	-0.3	-0.8
Leg fat percentage (right)	1.0	3.5	8.2	-0.6	-2.9	-1.4
Mineral and other dietary supplements	1.0	1.4	2.1	1.0	1.4	1.0
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.3	-0.6	-1.3	-2.1
Crohns Disease (2012)	0.9	1.4	2.1	0.5	-1.5	-1.4
Sensitivity / hurt feelings	0.9	1.6	2.5	-0.9	-1.6	-1.2
Impedance of leg (right)	0.9	4.1	7.3	-2.7	1.9	1.2
Number of live births	0.9	1.3	1.9	-1.3	1.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	8.5	-0.8	2.9	0.6
Happiness	0.9	1.0	2.3	-1.5	0.8	0.4
Arm fat mass (right)	0.9	3.6	7.4	-1.0	-2.7	-1.5
Headache pain in last month	0.9	1.6	3.1	1.3	0.2	1.8
Medication: Ventolin 100micrograms inhaler	0.9	1.2	2.2	-0.4	1.1	1.5
Body fat percentage	0.9	3.7	6.6	-1.7	-2.6	-1.3
Medication: Allopurinol	0.9	1.2	3.1	-0.7	0.1	1.8
Whole body fat mass	0.9	3.9	5.0	-2.2	-2.2	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	2.5	-1.6	0.6	-0.6
Breast cancer (self-reported)	0.9	1.1	1.4	-0.9	-1.2	-1.0
Number of operations (self-reported)	0.9	1.4	2.5	-1.6	-0.8	-1.0
Irritability	0.9	1.5	3.2	-0.8	-1.8	-0.8
Diastolic blood pressure, automated reading	0.9	2.7	6.8	2.6	0.2	1.1
Impedance of whole body	0.9	4.4	5.7	-2.4	2.2	1.6
Major Depression (MDD)	0.8	1.0	2.9	-0.2	0.0	-1.7
Lung FEV1/FVC ratio	0.8	4.3	7.3	-2.7	-0.3	-2.3
Hearing difficulty/problems: Yes	0.8	1.2	2.3	-1.0	0.3	1.5
High blood pressure	0.8	2.3	3.0	1.2	1.7	1.6
High blood pressure (mother)	0.8	1.1	1.9	0.2	1.4	1.1
Arm fat percentage (right)	0.8	3.2	8.0	-0.2	-2.8	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.4	1.0	1.2	0.6
Medication: Paracetamol	0.8	1.3	3.3	0.1	0.7	1.8
High blood pressure (siblings)	0.8	1.1	1.9	-0.6	1.1	1.4
Migraine (self-reported)	0.8	1.0	1.2	1.1	0.9	1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-1.4	0.9	-0.2
Leg fat mass (right)	0.8	3.0	6.6	-1.1	-2.6	-1.1
Long-standing illness, disability or infirmity	0.8	1.2	3.1	-1.8	-0.7	0.1
Arm fat mass (left)	0.8	3.3	6.9	-1.0	-2.6	-1.4
Leg fat percentage (left)	0.8	3.0	6.5	-1.0	-2.5	-1.2
Myopia	0.8	1.2	1.6	0.7	-1.3	-1.2
Schizophrenia (2018)	0.7	1.5	2.2	-1.2	1.5	-1.0
Schizophrenia vs Biploar Disorder	0.7	1.0	1.5	-1.2	0.8	-0.9
Prostate Cancer	0.7	1.0	1.6	-1.3	-0.1	1.2
Rheumatoid Arthritis	0.7	0.9	2.8	-0.2	-0.1	1.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.8	1.3	-0.7	0.7
Systolic blood pressure, automated reading	0.7	2.0	4.7	2.2	0.7	0.8
Diabetes (father)	0.7	0.9	1.9	0.9	-0.1	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.2	-0.1	-1.5	-0.8
Multivitamins +/- minerals	0.7	0.9	2.2	-1.5	0.3	-0.7
Waist circumference	0.7	2.4	4.5	-1.4	-2.1	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.0	-1.4	-1.1	0.2
Had menopause	0.7	0.9	1.5	1.0	0.4	1.2
Qualifications: None of the above	0.7	1.6	3.2	-1.8	-1.2	-0.2
Weight	0.7	3.6	6.0	-2.5	-1.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	1.8	-1.4	-0.9	0.8
Length of working week for main job	0.7	0.7	1.7	-1.3	0.2	0.7
Wheeze or whistling in the chest in last year	0.7	1.3	3.3	-1.8	0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	1.6	-0.5	1.3	0.7
Had major operations	0.7	0.8	1.6	-1.3	-0.8	-0.5
Arm fat percentage (left)	0.7	2.7	6.9	0.1	-2.6	-1.1
Wears glasses or contact lenses	0.7	0.8	1.6	0.5	0.7	1.3
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.0	0.3	0.7	1.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	-0.7	-1.4	-0.7
Arm fat-free mass (left)	0.7	3.6	8.5	-2.9	-1.1	-1.1
Fractured/broken bones in last 5 years	0.7	1.0	1.9	-0.5	1.4	0.9
Unable to work because of sickness or disability	0.7	0.9	1.9	-0.7	0.4	1.4
Commuting to job workplace: Cycle	0.7	0.9	1.4	-0.6	1.2	1.0
Leg fat mass (left)	0.7	2.6	5.2	-1.3	-2.3	-0.9
Arm predicted mass (left)	0.7	3.5	8.8	-3.0	-1.0	-0.9
Reaction Time	0.6	1.2	1.7	-0.8	1.3	1.1
Primary Biliary Cirrhosis	0.6	0.8	1.6	0.7	-0.6	-1.3
Systolic Blood Pressure	0.6	2.9	5.4	1.3	2.3	1.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	-0.5	0.3	1.4
Chronic bronchitis/emphysema (father)	0.6	0.7	1.1	-0.9	0.1	-1.1
Past tobacco smoking	0.6	1.2	2.3	-1.5	-0.2	-1.1
Nervous feelings	0.6	1.1	3.1	-1.7	-0.4	-0.3
Time employed in main current job	0.6	0.7	1.5	0.0	-0.7	-1.2
Illnesses of mother	0.6	0.8	1.1	0.6	-1.1	-1.0
Peak expiratory flow (PEF)	0.6	1.5	2.5	-0.9	1.6	-1.1
Pulse wave reflection index	0.6	0.7	1.2	0.2	1.1	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.0	-1.4	0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.9	-0.5	-1.7	0.5
Exposure to tobacco smoke outside home	0.6	0.8	1.7	0.8	-0.1	1.3
Number of children fathered	0.6	0.7	1.1	1.1	-0.9	-0.4
Medication: Ibuprofen	0.6	0.8	1.9	-1.4	-0.6	0.1
Supplements: Vitamin C	0.6	0.7	1.9	-1.4	0.1	0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.3	-0.0	0.9	1.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.3	-0.9	0.3	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.3	-1.2	-0.6	-0.5
Medication: Aspirin	0.6	0.7	1.2	-0.7	-1.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.1	1.4	0.7	1.1
Miserableness	0.6	1.1	2.0	1.1	-0.3	1.4
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	0.2	-0.1	1.5
Bipolar Disorder or Schizophrenia	0.5	1.3	2.7	-0.9	1.6	-0.6
Depressed Affect (Nagel 2018)	0.5	1.0	2.6	0.7	-0.1	1.6
Triglycerides	0.5	0.8	2.0	-0.3	-1.4	-0.5
Hypothyroidism (self reported)	0.5	1.2	3.3	-0.5	-1.8	-0.1
Pack years adult smoking proportion	0.5	0.7	1.1	-0.3	-0.9	-1.1
Hearing difficulty/problems with background noise	0.5	0.8	2.2	-0.5	0.1	1.5
Trunk fat-free mass	0.5	2.7	7.7	-2.8	0.2	-0.6
Hip circumference	0.5	2.3	2.9	-1.5	-1.7	-1.3
Alcohol intake versus 10 years previously	0.5	0.8	2.1	0.4	-1.4	0.3
Lung cancer (father)	0.5	0.6	1.5	-0.5	-1.2	-0.0
Impedance of arm (left)	0.5	2.2	4.0	-1.3	2.0	1.0
Trunk predicted mass	0.5	2.8	8.0	-2.8	0.2	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	-0.2	-0.7	-1.1
Arm fat-free mass (right)	0.5	2.7	7.6	-2.8	-0.5	-0.5
Age at first live birth	0.5	0.9	1.5	-1.0	1.2	-0.6
Shortness of breath walking on level ground	0.5	0.5	0.7	0.6	0.7	0.8
Eye problems/disorders: None of the above	0.5	0.6	1.6	-0.3	-0.0	-1.3
Emphysema/chronic bronchitis	0.5	0.5	1.0	-1.0	-0.8	-0.0
Arm predicted mass (right)	0.5	2.8	7.8	-2.8	-0.5	-0.5
Hypertension (Self-reported)	0.5	1.4	2.1	0.8	1.3	1.4
Ever taken oral contraceptive pill	0.5	0.5	1.6	1.3	-0.0	-0.1
Medication: Blood pressure	0.5	1.0	1.6	-0.2	1.1	1.3
Basal metabolic rate	0.5	2.6	6.9	-2.6	-0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.4	-1.2	0.1	-0.5
Age at First Birth	0.4	0.6	1.4	-1.2	0.7	0.1
HbA1C	0.4	0.4	0.9	0.3	-1.0	0.3
BMI	0.4	2.2	6.2	0.4	-2.5	-0.5
Average weekly spirits intake	0.4	0.5	1.2	-1.1	0.4	-0.0
Angina	0.4	0.6	1.7	-1.3	-0.0	0.2
Qualifications: CSEs or equivalent	0.4	0.6	1.1	1.1	-0.3	0.7
Serious illness, injury or assault to yourself	0.4	0.4	0.9	-0.9	-0.6	0.1
Heart attack	0.4	0.5	1.0	-0.5	-0.5	-1.0
Diabetes (self-reported)	0.4	0.6	1.1	-0.1	0.8	1.0
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.3	-1.1	0.6	0.1
Illnesses of siblings	0.4	0.6	0.9	0.6	-0.8	-0.9
Impedance of arm (right)	0.4	2.1	3.0	-1.6	1.7	0.8
Depression (self-reported)	0.4	0.5	1.3	0.4	0.1	-1.2
Breastfed as a baby	0.4	0.5	1.3	-0.1	-1.2	-0.4
Birth weight of first child	0.4	0.7	1.7	0.0	1.3	0.6
Loud music exposure frequency	0.4	0.4	1.3	-0.0	0.1	1.1
Birth weight	0.4	0.8	1.5	0.9	1.2	0.4
Qualifications: College or University degree	0.4	1.2	3.3	-0.2	-0.4	-1.8
Neck or shoulder pain in last month	0.4	0.5	1.0	-0.8	0.2	1.0
Medication: Aspirin	0.4	0.5	0.5	-0.7	-0.7	-0.7
Whole body fat-free mass	0.4	2.5	6.9	-2.6	-0.2	-0.8
Qualifications: nursing, teaching	0.4	0.7	1.9	1.4	0.0	-0.3
Whole body water mass	0.4	2.5	6.9	-2.6	-0.3	-0.8
High cholesterol (Self-reported)	0.4	0.7	2.0	0.1	0.4	1.4
Medication: Atorvastatin	0.4	0.5	1.1	-0.5	1.0	0.4
Illnesses of father: High blood pressure	0.4	0.4	0.9	0.3	1.0	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.0	1.0	0.4	0.4
Pain experienced in last month	0.4	0.7	1.5	0.4	0.7	-1.2
Supplements: Calcium	0.4	0.4	0.7	-0.9	0.2	0.7
Pack years of smoking	0.4	0.5	0.8	-0.3	-0.9	-0.9
Alzheimer’s Disease (in father)	0.3	0.4	0.6	-0.1	-0.7	-0.8
Fasting Glucose	0.3	0.4	0.6	-0.8	0.4	0.6
HDL Cholesterol	0.3	0.5	0.8	-0.4	0.9	0.8
LDL Cholesterol	0.3	0.5	1.3	-0.3	1.1	0.5
Blood Red Count	0.3	3.0	4.2	1.9	-1.1	-2.0
Neuroticism	0.3	0.7	1.9	-0.5	-1.4	-0.3
Tanning	0.3	3.2	6.9	-0.5	2.6	1.6
Relative age of first facial hair	0.3	0.5	1.1	0.2	-1.0	-0.7
Severe depression (siblings)	0.3	0.4	0.6	0.7	0.4	-0.8
Leg fat-free mass (left)	0.3	1.6	3.2	-1.8	-0.9	-1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.6	-0.5	-0.3	-0.8
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.9	0.9	-0.9	0.1
Stomach or abdominal pain in last month	0.3	0.4	0.6	-0.5	0.5	0.8
Leg predicted mass (left)	0.3	1.6	3.2	-1.8	-0.8	-1.0
Allergy	0.3	0.7	1.8	-0.5	1.4	-0.1
Fluid intelligence score	0.3	0.7	1.1	-0.7	-0.7	-1.0
Neuroticism score	0.3	0.6	1.8	-0.3	-1.3	-0.3
Falls in the last year	0.3	0.4	1.1	-0.3	-1.1	0.0
Asthma	0.3	0.7	2.0	0.1	-0.2	1.4
Prospective memory result	0.3	0.3	0.6	-0.2	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.1	0.1	1.1	0.1
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.7	-0.5	0.5	0.8
Angina (self-reported)	0.3	0.4	1.1	-1.1	0.0	0.0
Medication: Seretide 50 evohaler	0.3	0.4	0.7	0.1	0.8	0.6
Heart disease (mother)	0.3	0.3	0.9	-0.9	0.3	-0.1
Suffer from ‘nerves’	0.3	0.4	0.9	-0.2	-0.9	-0.5
Knee pain experienced in last month	0.3	0.4	0.8	-0.3	-0.9	-0.7
Illnesses of father: Heart disease	0.3	0.4	1.1	-1.0	0.3	0.5
Leg fat-free mass (right)	0.3	1.4	3.3	-1.8	-0.5	-0.8
Loneliness, isolation	0.3	0.5	1.2	-1.1	-0.3	-0.2
Diabetes diagnosed by doctor	0.3	0.5	1.0	-0.2	0.6	1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	0.7	0.8	0.8	0.1
Asthma (self-reported)	0.3	0.7	2.0	0.2	-0.3	1.4
Medication: Gliclazide	0.3	0.3	0.6	-0.8	-0.4	-0.4
Leg predicted mass (right)	0.3	1.5	3.3	-1.8	-0.6	-0.9
Hearing aid user	0.3	0.4	0.6	-0.0	0.7	0.8
Medication: Paracetamol	0.3	0.5	1.3	-0.1	-0.3	1.2
Cholesterol lowering medication	0.3	0.4	0.5	0.7	-0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	-0.6	-0.5	-0.9
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	-0.4	-0.3	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.7	-0.0	-0.8	-0.4
Irritable Bowel Disease (IBD)	0.2	0.4	1.0	0.2	-0.4	-1.0
Ovarian Cancer	0.2	0.3	0.7	-0.9	0.5	0.1
Mean Putamen Volume	0.2	0.2	0.3	-0.1	-0.5	-0.6
Blood Eosinophil Count	0.2	1.3	3.8	1.9	-0.3	0.3
Waist Hip Ratio (WHR)	0.2	0.9	2.4	-1.5	-0.1	0.6
Smoking Status	0.2	0.4	1.0	1.0	0.1	0.3
Allergy or Eczema	0.2	0.6	1.6	1.2	-0.5	0.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	-0.8	0.4	0.5
Hand grip strength (left)	0.2	0.6	1.8	1.3	-0.3	-0.0
Number of treatments/medications taken	0.2	0.4	0.9	-0.1	-0.9	0.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	-0.8	0.1	-0.1
Vitamin and mineral supplements	0.2	0.3	0.6	0.8	-0.4	-0.2
Hand grip strength (right)	0.2	0.5	1.4	1.2	0.2	0.0
Townsend deprivation index at recruitment	0.2	0.2	0.6	-0.8	0.2	0.3
Current tobacco smoking	0.2	0.3	0.9	-1.0	0.0	-0.0
Fed-up feelings	0.2	0.4	0.9	0.2	-0.5	1.0
Taking other prescription medications	0.2	0.4	0.7	0.6	0.2	0.8
Age when periods started (menarche)	0.2	0.5	0.8	-0.5	-0.6	-0.9
Medication: Atenolol	0.2	0.3	0.5	-0.7	-0.5	0.3
Number of incorrect matches in round	0.2	0.4	0.6	-0.8	-0.2	0.7
Medication: Simvastatin	0.2	0.3	0.7	-0.6	-0.1	0.8
Medication: Lansoprazole	0.2	0.2	0.5	-0.7	-0.1	-0.1
Exposure to tobacco smoke at home	0.2	0.3	0.4	-0.6	0.6	0.2
Number of full brothers	0.2	0.2	0.6	-0.8	-0.1	0.0
Medication: Blood pressure	0.2	0.4	0.9	-0.5	0.2	-1.0
Mean time to correctly identify matches	0.2	0.4	0.6	-0.1	0.7	0.8
Alcohol intake frequency.	0.2	0.4	0.7	0.7	-0.8	-0.3
Leg pain on walking	0.2	0.2	0.4	0.4	-0.6	-0.5
Mood swings	0.2	0.4	1.1	-0.4	0.0	1.1
Commuting to job workplace: Walk	0.2	0.2	0.4	-0.1	-0.3	-0.6
Smoking status: Current	0.2	0.3	0.5	-0.7	0.5	0.2
Guilty feelings	0.2	0.3	0.7	0.1	-0.5	0.8
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.0	-0.1	-0.8
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.3	0.8	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.6	0.9	-0.3	-0.9	-1.0
Bipolar Disorder (2018)	0.1	0.2	0.6	0.0	0.8	0.2
Neuroticism (Nagel 2018)	0.1	0.3	0.6	0.1	-0.8	0.5
Worry (Nagel 2018)	0.1	0.1	0.3	-0.2	-0.5	-0.2
Crohns Disease (2017)	0.1	0.2	0.7	0.3	-0.1	-0.8
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.2	-0.4	-0.7
Bipolar Disorder (2011)	0.1	0.1	0.1	-0.4	-0.3	0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.6	0.4	-0.0
Coronary Artery Disease (CAD)	0.1	0.2	0.4	-0.3	-0.6	-0.2
Lupus	0.1	0.2	0.3	-0.6	0.3	-0.5
Neuroticism (2016)	0.1	0.1	0.2	-0.1	-0.5	0.5
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.3	-0.2	0.3	0.5
Blood Platelet Count	0.1	0.7	0.9	-0.9	-0.6	0.9
Blood White Count	0.1	0.8	1.9	-0.6	-1.4	0.0
Heel T-Score	0.1	1.0	2.0	1.4	0.3	0.9
Respiratory disease	0.1	0.3	0.8	-0.4	-0.9	0.1
Hair Pigment	0.1	2.5	4.4	-2.1	1.2	-1.3
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.3	-0.4	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	-0.6	-0.3	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.8	-0.4	-0.0
Financial difficulties in last 2 years	0.1	0.1	0.2	0.3	0.3	0.4
Medication: Ramipril	0.1	0.2	0.6	-0.0	0.1	-0.7
Worrier / anxious feelings	0.1	0.3	0.7	-0.2	-0.8	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.7	-0.2	-0.1	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.3	-0.5	-0.0	0.4
Tense / ‘highly strung’	0.1	0.1	0.4	-0.6	0.1	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	-0.4	0.3	-0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.7	-0.3	0.2
Glaucoma (self-reported)	0.1	0.1	0.1	-0.2	0.4	-0.1
Medication: Omeprazole	0.1	0.1	0.3	-0.5	-0.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	0.3	0.1	0.6
Average weekly red wine intake	0.1	0.2	0.5	0.1	0.4	0.7
Ever had bowel cancer screening	0.1	0.1	0.2	0.2	0.4	-0.5
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.1	0.4	0.5
Back pain experienced in last month	0.1	0.1	0.2	-0.4	0.4	0.3
Osteoporosis (self-reported)	0.1	0.2	0.5	0.0	-0.7	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	-0.3	-0.1	-0.5
Number of self-reported non-cancer illnesses	0.1	0.1	0.3	-0.2	0.1	0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.3	0.3	0.6	-0.1
Financial situation satisfaction	0.1	0.1	0.3	-0.6	0.2	-0.1
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.1	-0.1	-0.5
Medication: Lisinopril	0.1	0.1	0.2	-0.5	0.0	0.3
Ever smoked	0.1	0.2	0.3	0.4	-0.5	0.5
Average weekly beer plus cider intake	0.1	0.2	0.4	-0.5	0.6	0.0
Ever depressed for a whole week	0.1	0.1	0.2	-0.5	-0.3	0.1
Depression (Nagel 2018)	0.0	0.0	0.1	0.3	-0.2	-0.1
Chronotype (morning person)	0.0	0.0	0.1	0.2	-0.3	-0.0
Medication: Metformin	0.0	0.0	0.0	0.2	-0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	0.1	-0.1	0.2
Medication for pain relief, constipation, heartburn	0.0	0.1	0.1	0.2	0.3	-0.3
Number of full sisters	0.0	0.0	0.0	-0.2	-0.0	-0.2

Hub : Genes

PRKG2

Models

Trait associations