Hub : Genes

PRMT5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.064	0.0260	1.0e-02	0.014	0.016	0.023	0.022	0.015	6.2e-03	3.7e-03	6.3e-04	8.8e-04	5.6e-03
2	GTEx	Whole Blood	0.149	0.0360	2.3e-07	0.139	NA	0.115	NA	0.120	8.5e-13	NA	9.2e-11	NA	3.6e-11
3	YFS	Blood	0.216	0.0239	0.0e+00	0.340	0.310	0.348	0.342	0.347	6.3e-116	8.4e-104	1.3e-119	6.1e-117	3.2e-119
4	TCGA	Pancreatic Adenocarcinoma	0.211	0.1290	7.0e-03	0.045	0.027	0.013	NA	0.040	5.8e-03	2.5e-02	8.8e-02	NA	8.8e-03
5	TCGA	Uterine Corpus Endometrial Carcinoma	0.354	0.1350	2.9e-03	0.025	0.008	-0.002	NA	0.019	6.7e-02	1.9e-01	3.7e-01	NA	9.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.0	0.1	0.3	-0.6	0.1
Bipolar Disorder or Schizophrenia	1.9	4.6	5.7	-2.2	-2.4	-2.2	1.6	-2.2
Depressed Affect (Nagel 2018)	0.7	1.4	1.9	1.2	-1.4	-1.3	0.4	-1.3
Depression (Nagel 2018)	0.5	0.7	1.5	1.2	-0.9	-0.9	-0.3	0.7
Intelligence (Savage-Jansen 2018)	1.3	4.1	12.1	0.1	2.0	2.0	-0.2	3.5
Neuroticism (Nagel 2018)	0.8	1.9	4.1	2.0	-1.3	-1.3	0.9	-1.1
Schizophrenia (2018)	4.0	8.4	10.0	-2.7	-3.2	-3.1	2.4	-3.0
Schizophrenia vs Biploar Disorder	0.5	0.6	1.1	-0.1	-0.9	-1.0	0.9	-0.6
Worry (Nagel 2018)	0.8	1.7	2.7	1.6	-1.6	-1.5	0.8	-0.8
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	-0.7	-0.3	-0.5	-1.1	0.4
Alzheimer’s Disease (in father)	1.3	1.4	2.4	0.3	-1.5	-1.4	1.5	-0.7
Alzheimer’s Disease (including proxy)	0.9	1.3	3.2	-0.2	-1.8	-1.8	0.2	-0.3
Crohns Disease (2017)	0.6	1.3	3.0	-0.2	1.6	1.7	-0.9	-0.1
Irritable Bowel Disease (IBD)	0.1	0.3	0.6	-0.4	0.5	0.8	0.3	-0.6
Ulcerative Colitis (UC)	0.2	0.5	1.2	-0.2	-0.5	-0.3	1.1	-0.8
Major Depression (MDD)	1.5	1.9	4.9	-0.2	1.2	1.1	-1.3	2.2
Reaction Time	0.1	0.3	0.9	0.9	-0.0	-0.1	0.6	0.2
Verbal and Numeric Reasoning (VNR)	2.0	4.8	10.7	-1.0	2.3	2.5	-0.8	3.3
Breast Cancer	0.8	1.8	3.1	-0.6	1.8	1.7	-1.6	-0.4
Ovarian Cancer	0.4	0.5	1.8	-1.3	0.5	0.5	0.2	-0.6
Prostate Cancer	2.1	3.0	5.4	-1.1	-2.3	-2.3	1.7	-0.5
Age at First Birth	0.8	1.1	2.5	0.5	1.6	1.5	-0.6	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.4	0.0	0.0	0.0	0.0	0.6
Body Mass Index (BMI) (2010)	0.2	0.2	0.4	0.2	-0.6	-0.7	-0.5	-0.3
Coronary Artery Disease (CAD)	0.6	0.8	3.0	-1.7	-0.4	-0.6	0.0	-0.6
Crohns Disease (2012)	1.7	2.7	4.1	-1.1	1.9	2.0	-2.0	0.5
Mean Putamen Volume	0.8	1.0	1.6	1.1	-1.2	-1.3	0.2	-0.7
Fasting Glucose	0.9	1.1	4.9	2.2	-0.0	-0.0	-0.0	-0.7
HbA1C	1.7	1.9	2.8	1.0	-1.6	-1.7	1.0	-1.5
HDL Cholesterol	0.6	0.9	1.7	-1.1	1.0	0.9	0.0	1.3
LDL Cholesterol	0.5	0.8	1.6	-0.9	0.4	0.6	-1.3	-1.0
Lupus	1.0	1.5	2.3	-1.5	1.3	1.1	-1.5	-0.3
Neuroticism (2016)	0.8	1.2	3.0	0.6	-1.4	-1.7	0.6	0.6
Primary Biliary Cirrhosis	0.3	0.5	2.0	-1.4	0.3	0.4	-0.4	-0.1
Rheumatoid Arthritis	0.3	0.4	1.1	1.1	-0.4	-0.1	0.1	-0.7
Schizophrenia (2014)	2.0	4.5	7.3	-1.6	-2.1	-2.0	2.1	-2.7
Triglycerides	0.6	0.9	1.6	-0.4	-1.1	-1.1	-0.5	-1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.2	-0.6	-0.1	0.4	0.5	-1.1
Ulcerative Colitis	0.3	0.4	0.8	-0.6	0.4	0.6	0.9	-0.6
Blood Eosinophil Count	1.5	11.7	15.8	-3.0	4.0	3.6	-4.0	2.2
Blood Platelet Count	0.3	3.1	6.3	-1.7	2.5	2.3	-0.8	-0.5
Blood Red Count	0.1	1.2	3.2	-1.8	-1.1	-1.1	-0.6	-0.1
Blood White Count	0.4	2.8	10.6	-1.6	0.5	0.7	3.3	-0.4
Heel T-Score	0.3	2.5	4.1	1.0	1.7	1.8	-1.1	2.0
BMI	0.1	0.7	2.4	0.7	0.4	0.5	-1.5	-0.3
Height	0.3	5.5	12.5	3.5	1.1	1.3	-1.9	2.9
Waist Hip Ratio (WHR)	0.9	4.0	9.5	-1.4	-1.7	-1.4	1.9	-3.1
Systolic Blood Pressure	1.9	9.5	19.2	-0.8	-4.4	-4.3	2.7	-1.5
Smoking Status	0.3	0.7	2.1	-1.5	0.3	0.1	-0.7	-0.9
Allergy or Eczema	0.4	1.1	2.8	-0.8	0.6	0.6	-1.2	1.7
Cardiovascular Disease	0.2	0.8	2.1	-0.1	-1.3	-1.5	-0.1	-0.3
Hypothyroidism (self reported)	0.4	0.9	1.6	1.0	-1.1	-1.3	0.6	-0.6
Respiratory disease	0.7	1.5	2.9	-1.2	-1.6	-1.7	-0.5	-0.6
Type 2 Diabetes (T2D) (2018)	0.9	1.6	5.3	0.3	-1.2	-1.2	-0.3	-2.3
Lung FEV1/FVC ratio	4.5	23.0	35.8	-0.0	5.8	6.0	-5.7	3.5
Lung FVC	0.2	1.0	2.1	1.4	0.9	1.0	0.7	0.8
Neuroticism	1.2	2.9	3.6	1.9	-1.9	-1.9	1.0	-1.7
Chronotype (morning person)	1.0	2.4	4.7	0.4	1.6	1.6	-2.2	1.4
Hair Pigment	0.0	0.6	1.9	-0.9	-0.1	-0.1	0.2	-1.4
Tanning	0.1	0.8	1.8	-0.2	1.3	1.3	0.1	-0.7
Hand grip strength (left)	0.5	1.2	1.7	-0.7	1.1	1.3	-1.1	1.3
Number of treatments/medications taken	1.0	1.7	4.2	-0.2	-2.0	-2.1	-0.5	0.5
Average weekly spirits intake	2.3	2.8	9.3	3.0	-0.3	-0.5	2.0	0.6
Sensitivity / hurt feelings	0.3	0.6	1.3	0.8	0.1	0.1	1.0	-1.2
Frequency of depressed mood in last 2 weeks	0.8	1.2	1.6	1.2	-1.1	-1.2	0.3	-1.3
Hearing difficulty/problems: Yes	0.3	0.4	0.9	-0.2	0.9	0.9	-0.4	-0.5
Relative age of first facial hair	0.8	1.6	2.3	-0.8	-1.5	-1.3	1.4	1.0
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.4	0.8	-2.0	-2.1	-0.4	-1.2
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	-1.0	-0.7	-0.7	0.6	0.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.4	-0.2	-0.1	-0.0	-0.5
Systolic blood pressure, automated reading	2.0	5.9	12.1	0.0	-3.5	-3.2	2.6	-0.6
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.4	-0.2	-0.9	-0.8	2.1	-1.7
Angina	2.1	2.7	6.5	-1.9	1.3	1.1	-2.5	0.9
Medication for hormone replacement therapy	0.6	0.7	2.9	-1.7	-0.0	0.1	-0.3	0.5
Vitamin and mineral supplements	0.7	0.9	3.2	-1.0	0.2	0.3	0.6	-1.8
Supplements: Zinc	0.5	0.6	1.5	1.2	-0.1	-0.1	-1.0	-0.6
Medication: Co-codamol	0.7	0.8	1.5	-0.2	-0.9	-0.8	1.2	-0.9
Medication: Metformin	1.3	1.9	2.6	1.6	-1.4	-1.5	0.8	-1.4
Diabetes (father)	1.3	1.6	3.1	0.1	1.5	1.6	-1.8	-0.5
Diabetes (mother)	0.6	0.8	2.9	1.7	-0.8	-0.6	0.5	-0.1
Severe depression (siblings)	0.2	0.2	0.9	-0.2	-0.3	0.0	-0.9	-0.1
Pack years adult smoking proportion	2.9	4.5	8.5	-1.8	-1.6	-1.5	2.5	-2.9
Impedance of leg (right)	0.1	0.4	2.0	-1.4	0.3	0.2	-0.0	0.2
Leg fat-free mass (left)	0.2	1.1	5.1	2.3	0.4	0.5	-0.4	-0.0
Trunk fat percentage	0.3	1.0	2.0	0.4	-1.4	-1.3	0.4	-1.1
Hand grip strength (right)	0.3	0.9	1.6	-0.5	0.8	1.0	-1.3	1.0
Townsend deprivation index at recruitment	5.2	7.3	16.0	-0.4	-4.0	-4.0	0.5	-2.1
Current tobacco smoking	1.0	1.6	4.0	0.1	-0.7	-0.8	1.7	-2.0
Average weekly fortified wine intake	0.6	0.7	1.7	1.3	0.5	0.4	0.9	0.8
Maternal smoking around birth	1.0	1.4	3.3	-0.5	-1.7	-1.8	0.5	-0.7
Fed-up feelings	1.0	1.8	2.2	1.4	-1.5	-1.5	1.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	4.8	1.8	-2.0	-2.2	0.7	-0.2
Relative age voice broke	0.6	0.9	3.6	-1.9	-0.4	-0.4	0.1	0.6
Taking other prescription medications	0.4	0.6	1.4	-0.2	-1.2	-1.1	-0.4	0.1
Age when periods started (menarche)	1.1	2.7	5.8	-1.1	2.4	2.1	-1.1	1.0
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.8	0.9	0.1	0.2	-0.2	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.0	1.2	-0.3	-0.2	0.2	1.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.1	0.4	-0.2	-0.3	1.4	-0.1
Qualifications: CSEs or equivalent	0.8	1.0	2.5	0.2	-0.9	-1.0	1.6	-0.9
Serious illness, injury or assault to yourself	1.2	1.5	2.6	-1.6	-1.5	-1.5	0.2	-0.8
High blood pressure	0.5	1.3	3.2	0.1	-1.8	-1.7	-0.3	-0.5
Hayfever, allergic rhinitis or eczema	0.4	0.8	2.8	0.0	-0.1	-0.2	-1.0	1.7
Multivitamins +/- minerals	0.8	1.0	3.1	1.0	0.5	0.4	-0.7	1.8
Stomach or abdominal pain in last month	0.4	0.5	0.8	0.4	-0.9	-0.9	-0.6	0.6
Supplements: Glucosamine	0.6	0.8	1.0	-1.0	1.0	0.9	-0.8	0.9
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.3	2.1	-0.4	-0.5	0.3	-1.5
Medication: Atenolol	0.3	0.4	1.0	-0.4	-0.6	-0.5	0.4	-1.0
Medication: Levothyroxine sodium	1.4	2.4	5.2	0.3	-2.2	-2.3	1.4	-0.4
Sitting height	0.1	0.4	0.7	0.8	0.4	0.6	-0.1	0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	-0.1	-0.7	-0.6	0.6	-1.4
High blood pressure (mother)	0.5	0.6	1.3	-0.8	-1.1	-0.9	0.2	-0.7
Body mass index (BMI)	0.1	0.5	1.1	1.1	-0.3	-0.2	-0.3	-1.0
Impedance of leg (left)	0.1	0.5	2.2	-1.5	-0.3	-0.4	0.2	-0.4
Leg predicted mass (left)	0.2	1.1	5.2	2.3	0.4	0.5	-0.4	-0.0
Trunk fat mass	0.1	0.5	1.2	1.1	-0.7	-0.6	0.0	-0.7
Waist circumference	0.3	1.2	2.5	0.9	-1.2	-1.1	0.3	-1.6
Number of incorrect matches in round	0.3	0.5	0.9	-1.0	0.7	0.7	0.6	0.5
Past tobacco smoking	0.2	0.4	1.4	0.6	0.1	0.3	1.2	0.3
Alcohol usually taken with meals	1.6	2.6	4.5	-0.1	2.0	2.1	-1.2	1.7
Nervous feelings	0.7	1.3	2.7	1.6	-1.1	-1.1	1.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.9	2.0	-1.4	-1.6	-0.5	-0.2
Hearing difficulty/problems with background noise	0.3	0.4	0.7	-0.8	0.6	0.6	-0.4	0.7
Hair/balding pattern: Pattern 2	0.9	1.1	2.2	0.5	1.5	1.4	-0.2	1.1
Had menopause	1.0	1.2	2.6	-1.5	-0.8	-0.7	1.6	0.2
Had other major operations	0.6	0.8	2.6	-0.1	0.7	0.6	-0.6	1.6
Forced vital capacity (FVC)	0.6	2.4	8.0	2.8	0.6	0.6	-0.9	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	1.4	-1.0	-0.9	0.3	1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	-0.6	-0.8	-0.6	1.4	0.0
Qualifications: None of the above	2.5	5.3	9.9	1.7	-3.0	-3.1	0.6	-2.0
Financial difficulties in last 2 years	0.7	1.0	1.8	-1.1	-1.0	-1.0	-0.1	-1.3
Mouth/teeth dental problems	2.7	4.2	7.0	1.8	2.7	2.3	-0.8	2.1
Heart attack	1.5	1.9	6.3	-2.5	-0.7	-0.7	-1.3	-0.7
Allergy	0.2	0.4	0.7	0.5	0.7	0.8	0.6	-0.3
Pain all over the body in last month	0.5	0.6	1.9	1.4	-0.2	-0.1	-0.6	-0.8
Diabetes (self-reported)	1.0	1.5	3.4	0.5	-1.1	-1.1	-1.3	-1.9
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	12.3	0.1	0.6	0.3	-1.7	3.5
Medication: Ramipril	2.0	2.5	5.0	1.7	-1.8	-2.2	-0.3	-1.2
Medication: Simvastatin	1.4	2.1	4.2	-1.0	-2.0	-2.0	0.1	-1.2
Fluid intelligence score	1.3	2.7	7.8	-0.5	1.6	1.7	-0.3	2.8
Illnesses of siblings	2.9	4.0	7.0	1.2	2.3	2.4	-0.8	2.6
Neuroticism score	1.4	3.0	5.6	2.4	-1.5	-1.5	1.4	-1.7
Weight	0.2	0.9	4.1	2.0	0.2	0.4	-0.6	-0.4
Impedance of arm (right)	0.0	0.2	0.6	0.1	0.3	0.2	-0.7	0.7
Arm fat percentage (right)	0.1	0.4	1.2	1.1	-0.1	-0.1	-0.3	-0.7
Trunk fat-free mass	0.4	2.2	6.5	2.5	1.3	1.3	-0.9	0.8
Hip circumference	0.3	1.4	3.3	1.8	0.9	0.9	-1.2	0.8
Time employed in main current job	2.1	2.4	4.1	0.3	-1.7	-2.0	2.0	-0.9
Alcohol intake versus 10 years previously	0.7	1.0	2.0	0.5	-1.4	-1.3	0.9	-0.5
Father’s age at death	0.3	0.4	0.9	-0.2	0.7	0.7	0.9	-0.6
Worrier / anxious feelings	0.2	0.4	1.2	1.1	-0.4	-0.4	0.3	-0.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	3.9	1.1	-0.8	-0.9	1.1	-2.0
Falls in the last year	0.3	0.4	1.6	0.1	0.1	0.1	-0.4	1.3
Hair/balding pattern: Pattern 3	0.4	0.6	1.0	-0.1	0.9	0.7	-1.0	0.9
Number of live births	3.5	5.0	6.8	-0.1	2.6	2.6	-2.3	2.5
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	7.5	2.7	2.2	2.3	-2.5	2.6
Pulse rate	0.1	0.2	0.8	0.1	0.0	-0.1	0.4	-0.9
Happiness	0.2	0.2	0.4	0.2	0.4	0.2	0.7	0.5
Noisy workplace	1.0	1.3	5.1	-0.4	-0.3	0.1	1.0	-2.3
Qualifications: A levels/AS levels or equivalent	2.3	5.2	13.8	0.1	2.5	2.4	-0.4	3.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.5	-0.3	0.9	1.1	0.6	1.6
Mouth/teeth dental problems: Dentures	2.9	4.8	9.0	0.0	-2.6	-2.6	1.2	-3.0
Asthma	0.7	1.3	2.3	-1.5	-1.4	-1.4	-0.6	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.1	-1.4	0.8	0.6	-1.0	0.7
Medication: Cholesterol lowering	0.9	1.5	3.9	-2.0	-0.9	-1.0	-1.2	0.3
Depression (self-reported)	0.2	0.3	0.9	-0.9	0.4	0.4	-0.2	-0.5
Medication: Lansoprazole	1.7	1.9	4.9	-0.3	-1.0	-1.1	1.6	-2.2
Prospective memory result	5.2	6.4	9.1	-0.3	-2.9	-3.0	2.4	-3.0
Lung cancer (father)	0.5	0.6	2.3	-1.5	0.1	0.2	0.1	-0.9
Illnesses of mother	0.7	0.9	2.6	0.5	0.8	0.7	-0.7	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.2	11.7	2.2	2.5	2.5	-2.6	3.4
Pulse wave Arterial Stiffness index	4.4	5.2	8.7	0.7	2.6	2.7	-2.9	1.6
Impedance of arm (left)	0.0	0.2	0.5	-0.2	-0.6	-0.7	0.3	0.2
Arm fat mass (right)	0.2	0.6	2.5	1.6	0.2	0.3	-0.5	-0.5
Trunk predicted mass	0.4	2.2	6.6	2.6	1.3	1.3	-0.8	0.7
Standing height	0.2	2.4	5.0	2.2	1.5	1.5	-0.9	1.3
Length of working week for main job	0.6	0.7	1.0	-0.9	0.9	0.7	-1.0	-0.5
Exposure to tobacco smoke at home	2.6	2.9	4.6	-0.3	-2.1	-2.1	1.9	-1.3
Breastfed as a baby	0.7	0.9	2.8	0.0	0.9	0.8	0.2	-1.7
Tense / ‘highly strung’	0.7	1.1	2.4	1.2	-0.7	-0.8	-0.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.9	-0.5	-0.3	-0.4	0.1	-1.0
Hair/balding pattern: Pattern 4	0.4	1.1	1.6	-1.1	1.1	1.0	-0.6	1.3
Birth weight of first child	0.2	0.3	0.7	-0.3	0.9	0.8	-0.3	0.4
Peak expiratory flow (PEF)	1.1	2.5	4.5	1.1	1.6	1.6	-2.1	1.3
Pulse wave reflection index	6.5	8.0	13.5	-0.1	3.7	3.6	-2.4	2.8
Ever highly irritable/argumentative for 2 days	1.4	1.7	5.5	-0.0	-1.2	-1.2	0.3	-2.4
Loud music exposure frequency	2.5	2.7	4.2	-0.8	-2.0	-2.1	1.9	-1.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.4	-1.1	1.8	1.8	-0.4	1.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.8	0.8	-0.9	-0.6	-0.2	0.8
Blood clot in the leg (DVT)	1.0	1.3	2.8	-0.1	-1.0	-1.1	1.7	-1.2
Medication: Paracetamol	0.2	0.3	0.5	0.6	-0.6	-0.7	0.3	0.5
Headache pain in last month	0.5	0.8	3.0	0.4	0.1	0.1	-1.7	1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.1	0.8	1.4	1.6	1.8	-0.0
Glaucoma (self-reported)	1.8	2.1	5.3	-2.3	-0.5	-0.5	1.5	-1.5
Gout (self-reported)	1.9	2.6	5.5	1.2	-1.4	-1.4	1.4	-2.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.6	1.2	-1.5	-1.6	0.4	0.1
Medication: Amlodipine	0.1	0.1	0.4	0.1	0.2	0.1	-0.6	-0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.7	-1.6	-0.7	-0.6	-0.6	0.4
Birth weight	1.0	2.2	4.9	0.5	-2.2	-2.0	1.3	-0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.5	-0.2	0.6	0.5	1.5	-1.9
High blood pressure (siblings)	0.7	1.0	2.1	-0.3	-1.4	-1.4	0.4	-0.9
Forced vital capacity (FVC), Best measure	0.7	2.5	5.4	2.1	1.0	1.0	-0.9	2.3
Body fat percentage	0.2	0.8	1.3	0.5	-1.1	-1.0	0.5	-1.1
Leg fat percentage (right)	0.1	0.3	1.3	0.5	-0.2	-0.1	0.2	-1.1
Arm fat-free mass (right)	0.1	0.7	2.8	1.7	0.4	0.6	0.2	-0.3
Exposure to tobacco smoke outside home	2.1	2.8	4.3	1.0	-2.0	-1.9	2.1	-0.9
Comparative body size at age 10	0.4	1.1	2.5	0.9	1.3	1.6	-0.7	-0.1
Number of full brothers	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.6	-0.1
Worry too long after embarrassment	0.9	1.4	4.0	2.0	1.3	1.1	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.0	-0.7	-1.7	-1.7	0.2	-1.5
Wheeze or whistling in the chest in last year	1.0	1.8	3.8	-1.0	-2.0	-1.9	-0.3	-0.7
Number of children fathered	0.5	0.5	1.2	-0.2	0.8	1.1	-0.8	0.2
Reason for reducing amount of alcohol drunk: Health precaution	2.1	2.5	3.9	1.5	1.5	1.5	-2.0	1.5
Age at first live birth	0.6	1.1	2.5	-1.2	1.3	1.6	-0.2	-0.1
Pulse wave peak to peak time	3.7	4.3	8.2	-0.4	-2.3	-2.4	2.9	-1.5
Health satisfaction	3.9	5.1	13.3	-0.5	-2.2	-2.1	3.6	-1.6
Shortness of breath walking on level ground	0.5	0.6	0.9	0.7	-0.9	-0.9	-0.0	0.9
Qualifications: College or University degree	2.5	7.9	14.2	0.3	3.8	3.7	-2.7	2.1
Eye problems/disorders: None of the above	1.5	1.7	3.1	1.1	1.8	1.6	-1.2	0.6
Mouth/teeth dental problems: Loose teeth	2.9	3.4	6.6	0.5	-2.6	-2.5	1.8	-1.0
Emphysema/chronic bronchitis	3.4	3.9	8.2	-0.9	-2.7	-2.9	0.8	-1.6
Medication for pain relief, constipation, heartburn	0.4	0.6	2.0	1.4	0.0	0.2	-0.8	0.6
Neck or shoulder pain in last month	1.3	1.8	3.6	-1.0	-1.7	-1.9	1.2	-0.4
Medication: Blood pressure	0.7	1.2	2.7	0.0	-1.1	-1.2	-1.7	-0.7
Angina (self-reported)	2.0	2.6	5.2	-1.9	1.4	1.2	-2.3	0.8
Migraine (self-reported)	3.0	3.7	6.7	-0.6	2.2	2.2	-1.5	2.6
Medication: Ibuprofen	1.5	1.8	3.4	-1.9	1.2	0.9	-0.9	1.6
Medication: Allopurinol	2.3	3.0	6.2	1.5	-1.3	-1.5	1.6	-2.5
Medication: Omeprazole	0.0	0.1	0.2	-0.4	0.0	0.1	0.2	-0.2
Medication: Seretide 50 evohaler	1.8	2.1	2.9	1.4	-1.4	-1.2	1.7	-1.6
Mean time to correctly identify matches	0.1	0.1	0.3	0.6	0.3	0.1	0.4	0.1
Heart disease (mother)	0.1	0.1	0.2	-0.2	0.3	0.4	0.0	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	-0.3	-0.8	-0.9	0.0	-0.1
Whole body fat mass	0.2	0.6	1.6	1.3	-0.6	-0.5	0.0	-1.0
Leg fat mass (right)	0.1	0.4	1.1	1.0	-0.2	-0.1	0.1	-1.0
Arm predicted mass (right)	0.1	0.7	3.0	1.7	0.1	0.3	0.3	-0.3
Pulse rate, automated reading	1.6	5.3	11.8	1.0	-1.9	-1.5	2.8	-3.4
Alcohol intake frequency.	1.1	2.6	5.0	2.2	-1.3	-1.3	0.7	-2.0
Comparative height size at age 10	0.4	1.9	4.1	1.8	-0.4	-0.1	2.0	-1.5
Number of full sisters	0.5	0.5	1.5	0.3	-0.5	-0.6	0.8	-1.2
Suffer from ‘nerves’	0.8	1.2	1.8	1.3	-1.3	-1.3	0.8	-0.5
Overall health rating	1.7	3.7	7.2	0.6	-2.0	-2.2	1.5	-2.7
Chest pain or discomfort	0.4	0.5	2.0	0.3	-0.4	-0.5	-1.4	-0.2
Had major operations	0.3	0.4	1.8	0.3	0.2	0.2	-1.3	0.3
Age at last live birth	2.1	3.1	5.4	-2.3	2.0	2.1	-1.0	0.5
Family relationship satisfaction	0.2	0.3	0.5	0.7	-0.3	-0.4	-0.3	-0.7
Leg pain on walking	1.0	1.3	3.0	0.0	-1.7	-1.6	0.1	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-1.0	0.6	0.9	0.7	0.0
Commuting to job workplace: Car/motor vehicle	4.3	4.9	7.3	-0.8	2.5	2.7	-1.8	2.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.4	0.9	1.1	1.0	-1.2	0.3
Medication: Aspirin	1.0	1.3	2.5	-1.2	-1.0	-1.2	0.3	-1.6
Supplements: Vitamin C	0.3	0.4	0.7	0.7	-0.6	-0.8	0.4	0.3
Knee pain experienced in last month	0.1	0.1	0.5	0.7	0.1	-0.2	0.3	-0.1
Hypertension (Self-reported)	0.5	1.4	3.2	0.0	-1.8	-1.8	-0.6	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	3.2	-1.8	1.2	1.0	-0.4	1.3
Illnesses of father: Heart disease	1.1	1.5	5.3	-2.3	0.8	0.7	-0.4	-0.9
Illnesses of siblings: Diabetes	1.7	2.1	4.1	-0.5	-1.9	-2.0	0.8	-1.3
Smoking status: Previous	0.2	0.3	1.1	-0.6	-0.0	-0.2	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	1.7	0.7	1.1	1.0	-1.3	-0.0
Whole body fat-free mass	0.3	1.5	5.5	2.4	0.8	0.9	-0.6	0.1
Leg fat-free mass (right)	0.2	1.1	5.1	2.2	0.2	0.3	-0.3	-0.3
Arm fat percentage (left)	0.1	0.5	1.0	0.8	-0.6	-0.6	0.1	-1.0
Average weekly red wine intake	1.4	2.0	3.9	-0.2	2.0	1.7	-1.2	1.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.7	0.8	-0.7	-0.7	-0.8	-0.5
Mood swings	1.8	3.3	5.8	1.2	-2.4	-2.4	0.7	-1.8
Loneliness, isolation	1.7	2.4	3.6	1.8	-1.9	-1.7	0.9	-1.1
Long-standing illness, disability or infirmity	3.1	4.8	9.9	0.6	-3.1	-3.1	1.2	-1.7
Ever had bowel cancer screening	0.3	0.3	0.9	1.0	0.3	0.5	-0.5	-0.5
Diabetes diagnosed by doctor	1.0	1.7	4.7	0.9	-1.2	-1.2	-0.5	-2.2
Ever had stillbirth, spontaneous miscarriage or termination	3.1	3.3	5.5	0.5	1.9	1.7	-2.3	2.0
Friendships satisfaction	1.5	1.9	3.2	1.1	-1.6	-1.5	0.5	-1.8
Qualifications: nursing, teaching	2.4	3.7	6.9	-1.2	2.6	2.6	-1.3	1.5
Commuting to job workplace: Walk	1.1	1.2	4.4	-1.1	-0.5	-0.4	0.4	-2.1
Eye problems/disorders: Cataract	0.5	0.6	1.0	0.4	-1.0	-0.6	1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.9	1.5	4.4	-2.1	0.2	0.6	-1.6	0.4
Medication for cholesterol	0.8	1.2	2.8	-0.3	1.7	1.6	-0.5	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	5.9	-0.9	2.4	2.4	0.7	0.4
Back pain experienced in last month	1.3	1.9	2.9	-0.9	-1.6	-1.7	1.6	-0.5
Mineral and other dietary supplements	0.5	0.7	1.3	-0.8	-0.7	-0.7	1.2	-0.8
Breast cancer (self-reported)	1.5	1.8	2.4	1.5	1.1	1.3	-1.1	1.6
Asthma (self-reported)	0.6	1.2	2.5	-1.6	-1.3	-1.2	-0.5	0.1
Osteoporosis (self-reported)	1.0	1.2	2.2	0.5	-1.4	-1.5	0.9	-0.8
Osteoarthritis (self-reported)	0.4	0.5	1.0	0.2	1.0	0.9	0.4	0.5
Medication: Aspirin	0.9	1.1	2.5	-1.2	-0.9	-1.0	0.1	-1.6
Medication: Gliclazide	0.7	0.8	2.5	0.8	-0.7	-0.8	0.0	-1.6
Illnesses of father: None of the above (group 1)	0.9	1.1	3.5	0.5	0.9	0.8	-0.1	1.9
Smoking status: Current	0.9	1.4	3.2	0.2	-0.8	-0.9	1.5	-1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.9	1.4	0.9	1.0	0.2	0.8
Whole body water mass	0.3	1.5	5.9	2.4	0.8	0.9	-0.6	0.3
Leg predicted mass (right)	0.2	1.0	4.9	2.2	0.1	0.2	-0.3	-0.3
Arm fat mass (left)	0.1	0.6	2.3	1.5	-0.0	0.0	-0.3	-0.8
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	-0.1	-1.1	-1.2	-0.5	-0.3
Average weekly champagne plus white wine intake	1.4	1.9	4.1	-2.0	1.3	1.4	-0.3	1.3
Miserableness	0.2	0.4	0.8	0.4	-0.8	-0.9	0.5	-0.2
Guilty feelings	0.3	0.4	1.3	1.1	0.1	0.1	0.7	-0.2
Wears glasses or contact lenses	0.5	0.6	2.3	-0.2	0.6	0.5	0.3	-1.5
Ever taken oral contraceptive pill	1.0	1.1	4.0	-1.0	0.1	0.0	-2.0	0.8
Hearing aid user	0.4	0.5	0.9	-0.8	0.9	1.0	0.3	-0.1
Mother’s age at death	1.3	1.6	2.3	-1.4	1.4	1.5	-1.3	-0.4
Financial situation satisfaction	0.8	1.0	2.7	-0.5	-0.9	-1.1	-0.3	-1.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.2	0.5	-0.5	-0.4	0.3	-1.1
Commuting to job workplace: Public transport	1.7	2.0	3.7	0.5	-1.8	-1.9	1.6	-0.4
Eye problems/disorders: Glaucoma	1.0	1.2	2.2	-1.4	-0.5	-0.6	1.5	-1.2
Medication: Blood pressure	0.1	0.3	0.5	0.5	-0.6	-0.7	0.5	-0.2
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.5	0.1	-0.2	-0.2	1.9	-1.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	1.3	1.0	0.6	0.5	-1.0	1.2
High cholesterol (Self-reported)	1.2	2.1	4.9	-0.5	-2.2	-2.1	0.8	-0.5
Medication: Bendroflumethiazide	0.4	0.7	1.5	-0.1	-0.8	-0.8	-1.2	0.8
Medication: Paracetamol	0.3	0.5	1.0	-0.2	-1.0	-1.0	0.5	0.4
Medication: Lisinopril	0.7	0.9	1.2	1.1	-1.0	-0.9	0.7	-0.9
Medication: Atorvastatin	0.2	0.3	1.0	0.2	-0.4	-0.5	-1.0	0.0
Illnesses of father: High blood pressure	0.4	0.5	1.2	0.7	-0.3	-0.4	1.1	-0.7
Alcohol drinker status: Never	0.9	1.1	2.3	1.1	-0.5	-0.6	1.2	-1.5
Ever smoked	0.2	0.4	1.2	-0.1	0.6	0.4	-1.1	0.7
Basal metabolic rate	0.3	1.4	5.7	2.4	0.6	0.7	-0.5	0.0
Leg fat percentage (left)	0.2	0.7	2.5	0.6	-0.7	-0.6	0.4	-1.6
Arm fat-free mass (left)	0.2	1.0	3.3	1.8	0.8	0.9	-0.7	0.1
Number of operations (self-reported)	2.4	3.5	7.0	0.1	2.7	2.6	-1.3	1.4
Average weekly beer plus cider intake	2.5	3.6	10.6	-0.3	-1.8	-1.7	3.2	-1.2
Irritability	0.4	0.6	1.1	0.5	-0.9	-1.0	-0.7	-0.6
Risk taking	0.6	0.8	1.9	1.0	0.5	0.4	-1.4	0.9
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.9	1.2	2.0	1.7	-1.3	0.4
Fractured/broken bones in last 5 years	0.3	0.4	1.1	0.3	-0.5	-0.6	0.1	1.0
Age started oral contraceptive pill	0.3	0.4	1.7	1.3	0.4	0.4	0.3	0.3
Diastolic blood pressure, automated reading	0.6	1.9	4.7	0.2	-2.2	-1.9	1.0	0.2
Ever depressed for a whole week	0.1	0.2	0.6	-0.1	0.2	0.1	0.5	-0.8
Unable to work because of sickness or disability	1.3	1.7	3.7	0.5	-1.2	-1.1	1.4	-1.9
Commuting to job workplace: Cycle	0.4	0.5	2.3	-0.3	0.2	0.1	-0.2	1.5
Myopia	0.4	0.6	1.1	0.3	-0.9	-1.0	-0.1	-0.9
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.7	0.7	1.6	1.6	0.7	0.5
Cholesterol lowering medication	2.2	3.3	4.4	1.0	-2.0	-2.0	1.8	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.7	-0.9	0.1	0.2	0.5	-0.5
Pain experienced in last month	1.3	2.1	4.3	0.7	2.1	2.1	-1.0	0.7
Supplements: Calcium	0.3	0.3	0.6	0.8	-0.5	-0.4	-0.3	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.9	0.8	0.7	0.7	-0.1
Heart attack/myocardial infarction (self-reported)	1.4	1.8	6.0	-2.5	-0.8	-0.7	-1.1	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	3.1	0.0	-1.3	-1.4	1.8	-1.2
Heart disease (siblings)	2.5	3.1	7.6	-2.8	1.0	1.1	-1.6	-1.7
Alcohol drinker status: Previous	0.8	0.9	1.7	1.3	-0.9	-0.8	-0.1	-1.1
Pack years of smoking	2.6	3.8	7.6	-1.9	-1.2	-1.2	2.2	-2.8
Impedance of whole body	0.0	0.2	0.6	-0.8	-0.3	-0.3	0.2	-0.0
Leg fat mass (left)	0.1	0.5	1.2	1.1	-0.3	-0.2	0.0	-1.0
Arm predicted mass (left)	0.2	1.0	2.9	1.7	0.9	1.0	-0.6	0.1