Hub : Genes

PRR16

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0240	0.00082	0.057	0.010	0.027	0.038	0.047	1.7e-07	0.02000	0.00025	1.8e-05	1.8e-06
2	GTEx	Cells Transformed fibroblasts	0.0990	0.0400	0.00470	0.008	NA	0.023	NA	0.015	7.8e-02	NA	0.00730	NA	2.5e-02
3	GTEx	Muscle Skeletal	0.0858	0.0292	0.00055	0.027	NA	0.047	NA	0.041	9.7e-04	NA	0.00002	NA	6.3e-05
4	GTEx	Testis	0.1940	0.0660	0.00180	0.154	NA	0.101	NA	0.136	2.4e-07	NA	0.00003	NA	1.3e-06
5	YFS	Blood	0.0252	0.0115	0.00350	0.015	0.008	0.009	0.013	0.012	5.8e-06	0.00067	0.00040	3.4e-05	6.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.3	0.5	-0.1	-1.1	-0.9	0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	3.6	0.4	-0.8	-0.9	-1.9	0.4
Depressed Affect (Nagel 2018)	3.7	7.8	33.4	5.8	-0.9	0.4	2.1	-0.2
Depression (Nagel 2018)	1.8	2.8	5.0	2.2	-1.8	0.2	2.2	0.8
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.4	-1.5	0.5	-1.4	0.9	-0.8
Neuroticism (Nagel 2018)	2.8	6.7	23.2	4.8	-1.0	0.1	3.0	-0.6
Schizophrenia (2018)	0.4	0.7	2.8	0.1	-0.9	-0.2	-1.7	0.0
Schizophrenia vs Biploar Disorder	0.4	0.5	1.4	1.2	0.9	-0.0	0.3	-0.6
Worry (Nagel 2018)	2.3	4.9	15.0	3.9	-0.9	0.6	2.8	-0.5
Alzheimer’s Disease (in mother)	0.9	1.0	3.3	1.8	0.4	0.4	1.0	-0.7
Alzheimer’s Disease (in father)	0.5	0.6	1.9	0.7	-0.4	1.4	0.6	-0.0
Alzheimer’s Disease (including proxy)	1.1	1.7	4.7	2.2	-0.6	1.4	1.1	0.3
Crohns Disease (2017)	0.8	1.7	2.8	1.7	-1.5	-0.5	-0.9	1.6
Irritable Bowel Disease (IBD)	1.0	2.4	5.3	1.6	-1.7	0.5	-0.8	2.3
Ulcerative Colitis (UC)	0.8	1.5	3.4	1.3	-1.4	0.5	-0.3	1.9
Major Depression (MDD)	1.2	1.5	3.2	1.1	1.4	-0.5	1.8	-0.9
Reaction Time	2.0	3.7	6.9	-2.6	-0.9	2.1	-1.7	1.8
Verbal and Numeric Reasoning (VNR)	1.1	2.6	5.9	-2.4	1.1	-1.6	1.9	-0.1
Breast Cancer	0.6	1.6	3.1	-1.1	-1.0	1.8	1.3	0.8
Ovarian Cancer	0.7	1.0	2.6	0.4	0.6	-1.2	-1.6	0.6
Prostate Cancer	1.2	1.7	3.2	-1.8	1.0	1.1	-0.1	-1.7
Age at First Birth	1.2	1.8	3.3	-1.4	0.5	-1.8	-1.8	0.1
Bipolar Disorder (2011)	0.8	0.8	2.6	0.0	0.2	-1.6	-1.1	-0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.2	-0.5	0.5	0.4	1.1
Coronary Artery Disease (CAD)	0.9	1.0	1.9	1.4	0.4	-1.4	-0.8	-0.8
Crohns Disease (2012)	1.4	2.2	3.6	0.7	-1.7	0.9	-1.8	1.9
Mean Putamen Volume	0.2	0.2	0.3	0.1	-0.5	0.5	-0.4	0.5
Fasting Glucose	0.4	0.5	0.8	-0.8	0.2	0.9	-0.8	0.5
HbA1C	0.9	1.0	2.0	-1.4	1.0	0.2	0.5	-1.3
HDL Cholesterol	0.5	0.8	2.0	1.4	-1.3	-0.0	-0.5	-0.6
LDL Cholesterol	0.4	0.6	0.8	-0.9	0.6	-0.9	-0.8	0.7
Lupus	0.9	1.4	2.6	-1.6	0.6	-1.6	-0.5	-1.0
Neuroticism (2016)	0.8	1.1	4.5	2.1	-0.2	-0.6	0.1	-0.9
Primary Biliary Cirrhosis	0.3	0.5	0.9	0.8	-0.6	-0.1	-0.6	1.0
Rheumatoid Arthritis	0.9	1.3	2.5	-1.4	-0.7	-1.1	-0.2	1.6
Schizophrenia (2014)	0.3	0.7	1.9	0.7	-0.6	-0.7	-1.4	-0.4
Triglycerides	0.8	1.3	4.6	0.2	-1.0	-0.1	0.9	2.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.4	0.0	-1.8	0.7	-0.0	1.0
Ulcerative Colitis	1.6	2.4	4.7	1.6	-0.8	2.2	-0.7	1.8
Blood Eosinophil Count	0.1	1.1	2.7	-0.1	0.8	-1.4	-0.4	-1.6
Blood Platelet Count	0.3	3.9	8.8	-0.3	1.6	-3.0	-2.6	-1.1
Blood Red Count	0.0	0.3	0.9	-0.4	-0.2	0.4	1.0	-0.6
Blood White Count	0.3	2.1	5.1	1.3	0.3	-2.3	0.8	-1.8
Heel T-Score	0.5	4.0	9.9	-1.6	-0.9	0.9	-3.1	2.5
BMI	0.3	1.6	5.1	1.1	-1.3	-0.2	-0.2	2.2
Height	0.3	5.0	18.4	0.3	-1.5	4.3	1.5	-1.4
Waist Hip Ratio (WHR)	0.3	1.3	3.3	1.3	-0.2	-1.8	0.9	-0.7
Systolic Blood Pressure	1.2	5.8	12.4	-1.3	3.5	-3.1	1.5	-1.7
Smoking Status	0.6	1.3	2.8	1.5	0.6	0.4	1.1	-1.7
Allergy or Eczema	0.5	1.4	3.1	0.9	0.1	-1.8	1.7	-0.1
Cardiovascular Disease	0.9	3.1	8.0	2.1	1.3	-1.0	2.8	-0.8
Hypothyroidism (self reported)	0.2	0.5	1.6	-0.1	-0.3	-1.3	0.3	-0.8
Respiratory disease	1.0	2.2	7.5	1.6	0.4	-2.7	-0.4	-0.8
Type 2 Diabetes (T2D) (2018)	1.8	3.3	10.5	1.6	-3.2	0.2	-1.2	1.5
Lung FEV1/FVC ratio	1.5	7.6	20.5	-4.5	3.4	-0.5	-1.3	2.1
Lung FVC	0.6	2.8	9.7	1.4	0.8	-0.2	1.3	-3.1
Neuroticism	2.1	4.9	19.8	4.4	-0.6	-0.8	1.9	-0.7
Chronotype (morning person)	0.6	1.4	3.2	0.6	0.5	-1.8	1.2	1.4
Hair Pigment	0.0	0.8	2.3	-0.6	-1.5	-0.9	-0.2	0.6
Tanning	0.1	1.4	4.7	-1.1	2.2	0.6	0.7	0.2
Hand grip strength (left)	0.6	1.6	2.8	1.2	1.7	1.2	-1.0	-1.2
Number of treatments/medications taken	1.5	2.8	5.6	2.4	0.7	-2.2	1.7	0.1
Average weekly spirits intake	1.0	1.2	3.9	-0.3	-2.0	-0.7	-0.2	1.3
Sensitivity / hurt feelings	0.5	0.8	2.4	0.9	-0.4	-0.5	1.6	-0.6
Frequency of depressed mood in last 2 weeks	3.9	5.4	11.2	3.3	-2.5	0.5	2.7	1.6
Hearing difficulty/problems: Yes	1.2	1.8	4.8	1.0	-2.2	-0.1	0.4	1.7
Relative age of first facial hair	0.6	1.3	2.7	1.7	0.9	1.6	0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	0.4	-0.7	-0.9	1.0	0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.6	-0.2	1.6	0.7	-0.1	-0.9
Ever had hysterectomy (womb removed)	0.3	0.3	1.0	-1.0	-0.6	0.1	-0.2	0.5
Systolic blood pressure, automated reading	1.0	2.9	8.3	-0.8	2.2	-2.9	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.1	0.1	-1.1	1.0	0.2	0.6
Angina	2.3	3.0	8.4	-0.3	-2.2	-0.2	1.4	2.9
Medication for hormone replacement therapy	1.8	2.0	3.6	1.8	1.9	-1.3	-0.5	-1.2
Vitamin and mineral supplements	1.5	2.0	3.8	-1.5	-1.4	0.6	-1.9	1.3
Supplements: Zinc	0.4	0.4	0.8	0.9	-0.4	0.6	0.6	0.5
Medication: Co-codamol	1.4	1.6	4.5	2.1	-1.7	-0.3	-0.2	0.5
Medication: Metformin	0.4	0.5	1.7	0.8	-0.3	1.3	-0.3	-0.3
Diabetes (father)	0.6	0.7	1.5	1.2	-1.0	0.4	0.9	0.3
Diabetes (mother)	2.0	2.6	6.4	-0.6	-2.5	0.4	2.1	1.2
Severe depression (siblings)	0.8	0.9	1.9	0.8	-0.5	-0.6	1.4	1.2
Pack years adult smoking proportion	0.8	1.2	2.6	-1.6	0.8	1.5	-0.4	0.2
Impedance of leg (right)	0.5	2.5	6.4	-1.0	2.1	-0.5	-0.7	-2.5
Leg fat-free mass (left)	0.3	1.7	3.6	1.2	-1.6	1.9	0.4	0.9
Trunk fat percentage	0.3	1.3	3.0	1.0	-1.7	0.1	0.1	1.6
Hand grip strength (right)	0.3	0.9	2.6	1.6	0.2	0.9	-1.0	-0.5
Townsend deprivation index at recruitment	0.9	1.2	3.8	0.4	0.2	-1.4	1.9	0.1
Current tobacco smoking	1.6	2.7	8.1	1.1	1.4	-0.9	1.1	-2.9
Average weekly fortified wine intake	0.9	1.0	1.9	1.4	-1.1	-1.4	0.2	0.2
Maternal smoking around birth	0.5	0.8	1.2	0.9	-0.2	1.1	1.1	-0.9
Fed-up feelings	3.1	5.6	20.3	4.5	-1.3	2.0	1.1	-0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	3.3	0.9	-0.8	0.7	1.8	0.2
Relative age voice broke	0.2	0.2	0.7	0.7	-0.3	0.1	0.8	-0.1
Taking other prescription medications	1.4	2.1	7.3	2.7	0.8	-0.5	1.5	-0.3
Age when periods started (menarche)	1.5	3.7	4.8	2.2	1.8	2.0	1.7	-1.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.1	-0.1	-0.6	0.2	0.7	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.0	-1.5	-1.9	2.2	-1.2	1.2
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	5.8	0.3	-0.7	-2.4	-1.1	1.2
Qualifications: CSEs or equivalent	0.6	0.8	3.5	1.9	-0.1	0.7	0.3	-0.1
Serious illness, injury or assault to yourself	1.1	1.4	3.0	1.0	-0.2	-1.6	1.7	0.3
High blood pressure	0.9	2.4	7.1	2.0	0.6	0.3	2.7	0.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.3	1.1	-0.1	-1.8	1.0	-0.1
Multivitamins +/- minerals	1.1	1.4	3.8	0.8	1.1	-0.5	1.2	-2.0
Stomach or abdominal pain in last month	2.3	2.9	11.7	3.4	-0.3	-1.1	1.0	-0.7
Supplements: Glucosamine	1.4	1.9	3.7	1.9	1.8	0.2	1.2	-1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	4.0	1.0	0.8	0.1	2.0	-1.0
Medication: Atenolol	0.8	1.0	2.9	0.7	-0.3	-1.2	0.4	1.7
Medication: Levothyroxine sodium	0.4	0.6	1.5	1.2	-0.2	-0.8	-0.8	-0.5
Sitting height	0.4	3.1	9.7	1.1	-2.2	3.1	0.1	-0.2
Chronic bronchitis/emphysema (father)	1.5	1.8	5.5	0.8	-1.7	0.4	2.3	0.1
High blood pressure (mother)	1.0	1.4	3.3	-0.0	1.3	-0.7	1.3	-1.8
Body mass index (BMI)	0.5	2.1	4.2	2.0	-1.2	-0.9	0.3	2.1
Impedance of leg (left)	0.7	3.6	9.9	-1.1	2.4	-0.6	-1.1	-3.1
Leg predicted mass (left)	0.3	1.8	3.6	1.4	-1.6	1.9	0.4	0.9
Trunk fat mass	0.4	1.6	3.7	1.1	-1.9	0.7	0.2	1.6
Waist circumference	0.4	1.5	2.3	1.5	-1.0	-1.2	0.7	1.4
Number of incorrect matches in round	0.2	0.3	1.1	-0.3	1.0	0.2	0.3	-0.4
Past tobacco smoking	0.8	1.4	3.9	-0.1	0.2	-2.0	-1.6	-0.7
Alcohol usually taken with meals	1.5	2.4	5.2	1.5	-1.3	-1.7	-2.3	-0.4
Nervous feelings	0.8	1.6	4.4	2.1	-0.7	0.5	1.6	-0.4
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	10.8	3.3	-1.9	0.1	2.6	-0.3
Hearing difficulty/problems with background noise	0.6	0.9	3.7	0.7	-0.5	0.0	1.9	-0.4
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-1.1	-0.1	0.0	-0.8	0.7
Had menopause	0.2	0.2	0.9	-0.2	0.4	0.0	-0.3	-1.0
Had other major operations	0.7	0.8	1.4	1.1	-0.2	-1.2	0.4	1.2
Forced vital capacity (FVC)	0.7	2.7	7.7	0.8	0.0	2.8	0.7	-2.2
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	5.5	-1.8	-2.1	2.4	-1.2	1.1
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	9.3	0.5	-1.2	-0.7	3.0	2.2
Qualifications: None of the above	1.8	3.8	11.3	1.4	-1.1	3.4	1.9	0.7
Financial difficulties in last 2 years	2.4	3.2	5.7	2.4	-1.5	-2.0	1.9	-0.6
Mouth/teeth dental problems	3.1	4.7	9.0	-2.5	3.0	1.7	-1.9	-1.2
Heart attack	1.3	1.6	3.6	-0.0	-1.5	-1.9	0.6	1.3
Allergy	0.7	1.7	3.5	-1.6	-0.4	1.9	-1.3	0.5
Pain all over the body in last month	1.5	1.6	2.8	1.2	-1.6	-0.5	0.7	1.7
Diabetes (self-reported)	1.2	1.9	3.5	1.7	-1.9	-0.6	-1.6	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.4	0.4	-1.2	-0.6	-0.3	1.1
Medication: Ramipril	1.0	1.3	4.1	1.3	0.5	-0.1	2.0	0.7
Medication: Simvastatin	1.3	1.9	5.4	0.6	-2.3	0.2	0.6	1.9
Fluid intelligence score	0.9	1.8	7.5	-2.7	0.8	-0.2	1.0	0.5
Illnesses of siblings	0.9	1.2	4.1	-0.5	-0.4	-0.0	-2.0	-1.3
Neuroticism score	1.6	3.3	12.5	3.5	-0.9	0.4	1.6	-0.6
Weight	0.2	1.1	1.9	1.4	-1.2	0.9	0.4	1.0
Impedance of arm (right)	0.2	0.7	2.8	-1.7	-0.4	0.3	0.1	-0.8
Arm fat percentage (right)	0.6	2.5	6.8	1.2	-2.0	-0.5	0.2	2.6
Trunk fat-free mass	0.2	1.0	4.2	0.6	-0.5	2.0	0.6	0.1
Hip circumference	0.2	0.9	1.9	1.1	-1.2	0.2	0.0	1.4
Time employed in main current job	1.5	1.8	5.4	-0.3	0.1	2.3	0.8	1.6
Alcohol intake versus 10 years previously	0.6	0.8	1.8	1.4	-1.0	-1.1	0.3	0.2
Father’s age at death	0.9	1.1	3.1	-0.7	0.3	-1.2	-1.8	-0.7
Worrier / anxious feelings	2.0	3.8	9.9	3.1	-0.8	-0.4	2.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	2.1	3.5	7.8	2.8	-2.7	0.4	1.0	0.9
Falls in the last year	0.6	0.8	1.8	-0.2	1.3	-0.1	1.2	-0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.8	0.5	0.3	0.8	-1.2
Number of live births	0.6	0.9	1.5	0.8	-1.2	0.9	0.3	1.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	5.8	-0.4	0.5	2.4	0.3	-1.2
Pulse rate	1.6	2.6	6.0	-0.6	-1.1	2.1	-2.5	-1.1
Happiness	0.2	0.2	0.8	0.9	-0.3	-0.1	0.0	0.1
Noisy workplace	0.8	0.9	3.9	0.3	-0.8	-0.0	-2.0	0.2
Qualifications: A levels/AS levels or equivalent	1.0	2.1	3.8	-1.9	1.7	-1.7	-1.0	-0.2
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.1	0.9	0.2	-0.8	-1.4	-1.8
Mouth/teeth dental problems: Dentures	0.6	1.1	3.3	-0.1	-0.7	-1.8	0.6	1.1
Asthma	0.8	1.5	5.3	0.3	1.4	-2.3	-0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	5.2	2.3	0.3	-0.1	0.8	-0.7
Medication: Cholesterol lowering	0.6	1.0	3.2	0.1	-1.3	-0.1	0.2	1.8
Depression (self-reported)	1.2	1.4	2.9	1.2	-0.9	-0.8	1.7	1.1
Medication: Lansoprazole	1.5	1.7	3.3	1.8	-1.7	-1.1	0.6	0.8
Prospective memory result	1.3	1.6	4.0	2.0	-0.4	1.2	-1.1	-1.1
Lung cancer (father)	0.8	0.9	2.6	-0.4	0.9	0.9	-0.1	-1.6
Illnesses of mother	1.2	1.4	3.3	-1.7	-0.1	0.6	-1.8	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.4	-0.3	0.4	2.1	0.6	-1.0
Pulse wave Arterial Stiffness index	0.7	0.8	2.4	-0.6	1.6	0.0	0.3	-1.2
Impedance of arm (left)	0.1	0.5	1.3	-1.1	-0.6	0.0	0.4	-0.7
Arm fat mass (right)	0.4	1.6	3.3	1.3	-1.7	-0.1	0.4	1.8
Trunk predicted mass	0.2	1.0	3.9	0.5	-0.6	2.0	0.6	0.1
Standing height	0.4	4.1	15.6	-1.1	-0.2	4.0	0.5	-1.9
Length of working week for main job	0.3	0.4	0.9	1.0	-0.2	0.3	0.9	-0.2
Exposure to tobacco smoke at home	0.8	0.9	1.7	0.7	-0.7	-1.3	-0.8	1.2
Breastfed as a baby	0.4	0.5	1.3	-0.5	-0.4	-0.8	-0.3	1.2
Tense / ‘highly strung’	0.6	1.0	3.0	1.7	-0.6	0.3	0.9	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	9.1	2.8	-0.8	0.1	3.0	1.0
Hair/balding pattern: Pattern 4	0.8	2.0	7.5	0.1	-2.7	0.7	0.6	1.2
Birth weight of first child	1.0	1.8	6.1	-2.5	0.5	0.8	-1.5	0.3
Peak expiratory flow (PEF)	0.9	2.2	3.6	-1.9	1.6	1.9	0.5	-1.0
Pulse wave reflection index	1.1	1.3	3.2	-0.9	1.8	-0.0	1.6	0.1
Ever highly irritable/argumentative for 2 days	1.7	2.0	5.0	2.2	-1.6	-0.1	1.1	1.1
Loud music exposure frequency	1.8	1.9	3.9	-0.7	-2.0	1.8	-0.5	1.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.9	1.0	0.1	-0.6	1.4	0.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.7	1.9	-0.7	-1.4	0.1	-1.1
Blood clot in the leg (DVT)	0.6	0.8	3.2	1.8	-0.5	0.1	0.3	-0.6
Medication: Paracetamol	1.2	1.9	4.9	1.5	-0.9	-2.2	1.3	0.3
Headache pain in last month	1.1	1.9	4.6	2.1	-0.6	-2.1	-0.6	0.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.7	-0.5	1.0	0.0	-1.4	-2.2
Glaucoma (self-reported)	0.6	0.7	1.7	-0.8	0.6	-1.3	-0.8	-0.5
Gout (self-reported)	0.6	0.8	2.4	0.8	-0.2	0.6	1.5	0.5
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.9	-0.2	-0.4	-1.4	-0.7	-0.5
Medication: Amlodipine	0.7	1.0	1.9	1.1	-0.7	-0.8	0.7	1.4
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.1	0.4	1.1	-1.8	-0.1	-0.2
Birth weight	1.1	2.5	6.8	-2.6	-0.4	0.6	-2.1	0.6
Chronic bronchitis/emphysema (mother)	2.3	2.6	3.8	1.9	1.4	-1.3	1.4	-1.9
High blood pressure (siblings)	0.5	0.7	2.0	0.5	0.9	-0.6	1.4	0.4
Forced vital capacity (FVC), Best measure	0.6	2.3	7.1	0.7	-0.2	2.7	0.9	-1.7
Body fat percentage	0.3	1.1	2.6	1.1	-1.3	-0.3	-0.1	1.6
Leg fat percentage (right)	0.2	0.9	1.9	1.4	-0.3	-1.0	-0.8	0.8
Arm fat-free mass (right)	0.1	0.7	2.6	0.9	-0.2	1.6	0.0	0.1
Exposure to tobacco smoke outside home	1.0	1.3	2.9	1.3	-1.7	-0.5	1.0	-0.6
Comparative body size at age 10	1.2	3.3	7.0	-1.6	-1.8	-0.5	-2.6	1.9
Number of full brothers	0.7	0.8	1.7	0.4	0.9	1.1	1.3	-0.5
Worry too long after embarrassment	0.9	1.6	3.9	0.9	-0.4	-1.6	2.0	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	6.7	2.6	-1.3	-0.5	1.7	-0.3
Wheeze or whistling in the chest in last year	1.0	1.7	3.1	1.8	-0.3	-0.7	1.6	-1.5
Number of children fathered	1.5	1.7	2.9	1.5	-1.7	-1.1	-0.9	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	0.5	0.0	-0.9	-0.7	-1.2
Age at first live birth	0.8	1.4	3.1	-1.2	0.3	-1.5	-1.8	-0.3
Pulse wave peak to peak time	0.7	0.9	2.9	0.5	-1.7	0.3	-0.2	1.0
Health satisfaction	1.2	1.6	7.4	2.7	-0.2	-0.0	0.7	-0.0
Shortness of breath walking on level ground	1.7	2.0	4.6	2.1	-2.1	0.6	0.6	0.2
Qualifications: College or University degree	2.5	7.9	20.2	-2.3	2.4	-4.5	-2.7	-1.0
Eye problems/disorders: None of the above	0.5	0.6	2.3	-0.2	0.6	1.5	0.2	-0.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	0.1	0.1	0.5	1.3	-1.1
Emphysema/chronic bronchitis	1.0	1.1	2.6	1.6	0.9	-1.1	-0.4	-0.9
Medication for pain relief, constipation, heartburn	1.7	2.9	7.1	-2.7	0.1	1.4	-2.2	0.7
Neck or shoulder pain in last month	2.4	3.4	9.8	3.1	-2.1	-1.2	1.2	0.5
Medication: Blood pressure	1.4	2.4	7.2	1.4	-0.3	-0.3	2.7	1.7
Angina (self-reported)	2.3	3.1	8.2	-0.3	-2.2	-0.3	1.5	2.9
Migraine (self-reported)	0.5	0.7	1.9	0.3	-1.1	-1.4	-0.0	0.4
Medication: Ibuprofen	1.4	1.7	6.4	2.5	0.7	-0.5	1.0	-0.7
Medication: Allopurinol	0.3	0.4	0.9	0.7	-0.3	0.2	1.0	0.7
Medication: Omeprazole	1.7	2.0	6.1	1.1	0.4	0.4	2.5	-1.6
Medication: Seretide 50 evohaler	0.5	0.6	1.3	0.6	0.8	-0.8	1.1	-0.4
Mean time to correctly identify matches	1.7	3.2	6.1	-2.5	-1.3	1.7	-1.5	1.8
Heart disease (mother)	0.2	0.2	0.7	-0.2	0.2	-0.6	0.8	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.7	0.8	-0.7	-0.8	-0.3	0.2
Whole body fat mass	0.3	1.2	2.2	1.3	-1.5	0.4	0.2	1.4
Leg fat mass (right)	0.2	0.7	2.0	1.4	-0.7	0.1	-0.5	0.9
Arm predicted mass (right)	0.1	0.7	2.4	1.0	-0.4	1.6	-0.1	0.1
Pulse rate, automated reading	0.7	2.2	7.7	0.2	-1.2	1.0	-2.8	-0.9
Alcohol intake frequency.	1.4	3.2	7.9	2.2	-2.8	-0.4	0.8	1.5
Comparative height size at age 10	0.4	1.9	4.5	-2.1	-0.9	1.6	-0.8	-1.1
Number of full sisters	0.4	0.5	1.2	0.6	0.7	0.4	1.1	-0.4
Suffer from ‘nerves’	2.8	4.3	13.5	3.7	-1.4	1.0	2.3	-0.3
Overall health rating	2.4	5.2	13.4	3.7	-1.1	0.1	3.3	0.5
Chest pain or discomfort	0.4	0.6	1.6	1.3	-1.1	0.0	-0.1	-0.2
Had major operations	0.8	1.0	1.6	1.2	0.7	-0.3	1.3	-1.2
Age at last live birth	0.9	1.3	5.0	0.8	0.1	-2.2	-0.7	-0.6
Family relationship satisfaction	1.5	1.9	4.6	2.1	-1.4	-1.3	-0.8	-0.8
Leg pain on walking	1.0	1.2	2.9	1.1	-1.7	0.0	0.1	1.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.3	0.5	-0.7	0.2	-0.0	1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.4	1.2	-1.6	0.1	0.1	0.3
Illness, injury, bereavement, stress in last 2 years	1.7	2.1	5.2	-2.3	-0.1	1.4	-0.8	1.7
Medication: Aspirin	0.4	0.5	1.5	-0.1	-0.6	-0.2	0.8	1.2
Supplements: Vitamin C	1.8	2.1	4.5	2.1	0.9	-0.8	2.0	-0.6
Knee pain experienced in last month	1.7	2.7	5.9	2.2	-2.4	-0.0	1.1	1.2
Hypertension (Self-reported)	1.1	3.0	9.0	2.4	0.5	0.3	3.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.1	0.0	-0.1	0.5	-0.5	-1.1
Illnesses of father: Heart disease	2.8	3.9	18.1	0.3	0.0	-4.3	1.1	0.5
Illnesses of siblings: Diabetes	0.9	1.1	3.4	0.4	-0.1	1.3	1.8	0.1
Smoking status: Previous	1.0	1.4	4.3	-0.0	0.1	2.1	1.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	4.3	-0.2	-0.8	2.1	-0.6	-0.2
Whole body fat-free mass	0.2	1.3	4.1	0.8	-1.1	2.0	0.5	0.5
Leg fat-free mass (right)	0.3	1.6	4.0	1.0	-1.6	2.0	0.2	0.6
Arm fat percentage (left)	0.7	2.9	7.2	1.5	-2.1	-0.7	0.3	2.7
Average weekly red wine intake	0.4	0.6	1.0	0.7	-0.4	-1.0	-1.0	-0.3
Handedness (chirality/laterality): Left-handed	1.8	2.1	8.0	-2.8	-0.5	-0.5	-1.1	0.9
Mood swings	2.2	3.9	17.1	4.1	-1.1	0.2	1.0	-0.1
Loneliness, isolation	4.3	5.9	15.6	3.9	-1.9	2.0	2.6	0.0
Long-standing illness, disability or infirmity	3.2	4.9	10.0	3.2	-2.3	-1.3	2.1	1.8
Ever had bowel cancer screening	0.4	0.5	1.6	-0.7	1.3	0.0	-0.3	0.4
Diabetes diagnosed by doctor	2.0	3.4	9.1	2.2	-3.0	0.3	-0.9	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.4	1.4	0.2	-0.1	1.5	-0.6
Friendships satisfaction	0.3	0.4	1.0	0.2	-0.4	-1.0	0.4	-0.7
Qualifications: nursing, teaching	1.4	2.2	4.8	-1.9	1.1	-2.2	-1.1	-0.5
Commuting to job workplace: Walk	1.0	1.1	2.4	-1.0	1.5	0.8	-0.9	-0.8
Eye problems/disorders: Cataract	0.2	0.2	0.4	0.4	-0.2	-0.6	0.6	-0.0
Mouth/teeth dental problems: Mouth ulcers	3.6	5.7	9.8	3.1	-2.6	-0.6	2.8	1.9
Medication for cholesterol	1.3	2.0	5.6	-2.4	-0.8	1.0	-1.3	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.2	0.6	0.6	0.7	1.5	-0.8
Back pain experienced in last month	1.6	2.4	6.0	2.4	-2.1	-0.7	-0.6	-0.8
Mineral and other dietary supplements	2.2	2.9	10.0	-0.4	-3.2	-0.1	-1.4	1.6
Breast cancer (self-reported)	0.5	0.5	1.6	-0.4	0.5	0.1	0.8	-1.2
Asthma (self-reported)	0.8	1.6	4.6	0.1	1.5	-2.1	-0.3	-1.1
Osteoporosis (self-reported)	0.4	0.5	1.8	-0.7	0.3	-1.3	-0.1	-0.3
Osteoarthritis (self-reported)	3.8	4.9	8.7	2.6	-2.4	-0.3	1.8	3.0
Medication: Aspirin	0.6	0.8	1.9	-0.0	-0.8	-0.4	1.1	1.4
Medication: Gliclazide	2.4	2.7	7.4	2.2	-2.7	-0.2	0.0	1.1
Illnesses of father: None of the above (group 1)	1.9	2.4	6.3	-1.0	0.4	2.5	-2.0	0.5
Smoking status: Current	1.7	2.7	7.4	1.6	0.9	-0.8	1.4	-2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	1.1	-0.0	-0.5	1.1	0.4	-0.2
Whole body water mass	0.2	1.2	3.8	0.7	-1.0	1.9	0.5	0.6
Leg predicted mass (right)	0.3	1.5	4.0	0.9	-1.5	2.0	0.1	0.6
Arm fat mass (left)	0.5	1.9	3.9	1.4	-1.8	0.0	0.6	2.0
Number of self-reported non-cancer illnesses	2.2	3.8	14.0	3.7	-0.8	-1.2	1.5	0.6
Average weekly champagne plus white wine intake	0.2	0.2	0.7	0.4	-0.8	0.2	-0.6	-0.2
Miserableness	1.1	1.9	8.1	2.9	0.5	-0.7	0.7	-0.2
Guilty feelings	1.0	1.5	2.6	1.5	-0.7	-1.5	1.6	-0.1
Wears glasses or contact lenses	0.5	0.6	1.4	-0.1	-0.7	-0.1	1.0	1.2
Ever taken oral contraceptive pill	1.0	1.1	3.2	-0.3	-1.8	-0.1	-0.2	1.5
Hearing aid user	1.2	1.4	3.5	1.0	1.3	-1.9	-0.5	-0.6
Mother’s age at death	0.7	0.9	2.4	-0.3	-0.8	-1.6	-1.2	-0.1
Financial situation satisfaction	3.4	4.3	8.3	2.9	-1.7	0.7	2.9	1.2
Tinnitus: Yes, now most or all of the time	0.8	0.9	1.6	0.6	0.2	-1.2	-1.3	-1.1
Commuting to job workplace: Public transport	0.9	1.1	4.2	-2.0	0.6	0.3	-0.3	0.9
Eye problems/disorders: Glaucoma	0.4	0.5	1.1	-0.7	0.2	-1.0	-0.9	-0.0
Medication: Blood pressure	0.7	1.3	4.8	1.0	0.8	-0.4	2.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.6	1.0	-1.3	-0.6	0.4	0.6
Supplements: Fish oil (including cod liver oil)	3.6	4.7	13.5	-1.2	3.7	0.5	0.6	-2.8
High cholesterol (Self-reported)	0.3	0.5	1.2	0.0	-0.8	1.1	0.9	-0.3
Medication: Bendroflumethiazide	0.3	0.5	1.0	-0.8	0.1	1.0	0.3	0.7
Medication: Paracetamol	0.8	1.2	4.3	0.7	0.0	-2.1	1.1	0.4
Medication: Lisinopril	0.9	1.2	3.0	0.5	1.7	0.2	1.7	0.3
Medication: Atorvastatin	1.0	1.2	2.7	1.0	1.3	-0.1	1.6	-0.8
Illnesses of father: High blood pressure	1.6	2.0	8.9	-0.2	-0.7	-3.0	0.3	-0.6
Alcohol drinker status: Never	1.1	1.3	2.6	-0.4	-0.7	-1.6	-0.9	1.5
Ever smoked	0.7	1.2	3.6	-0.7	0.5	1.9	1.3	0.2
Basal metabolic rate	0.2	1.1	2.8	1.0	-1.1	1.7	0.4	0.5
Leg fat percentage (left)	0.2	0.6	1.6	1.2	-0.0	-0.8	-0.9	0.3
Arm fat-free mass (left)	0.1	0.5	2.1	0.7	-0.4	1.4	0.2	0.1
Number of operations (self-reported)	1.7	2.6	5.5	1.4	0.4	-2.1	2.3	0.9
Average weekly beer plus cider intake	1.3	1.8	5.0	-0.9	1.4	0.6	2.2	1.1
Irritability	0.7	1.2	2.0	0.8	1.0	1.3	-0.8	-1.4
Risk taking	0.5	0.8	1.9	0.2	0.7	-0.8	0.9	-1.4
Ever had prostate specific antigen (PSA) test	2.3	2.7	5.6	-2.3	0.3	1.2	-2.4	-0.9
Fractured/broken bones in last 5 years	0.3	0.4	1.3	-0.1	-0.7	0.3	1.1	0.3
Age started oral contraceptive pill	0.6	0.8	2.2	0.4	-0.2	-1.5	0.4	1.1
Diastolic blood pressure, automated reading	0.6	1.8	4.3	-0.6	2.1	-0.8	0.2	-2.0
Ever depressed for a whole week	2.6	3.3	9.2	1.4	-1.7	-1.1	3.0	1.1
Unable to work because of sickness or disability	0.8	1.0	3.2	1.2	-0.1	-0.5	1.8	-0.4
Commuting to job workplace: Cycle	1.1	1.4	5.5	-2.3	0.5	0.8	0.4	-0.7
Myopia	0.1	0.2	0.7	-0.8	-0.6	0.1	-0.1	-0.0
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.3	-1.9	-0.3	0.2	-2.5	-1.1
Cholesterol lowering medication	1.2	1.8	5.3	2.3	-0.4	0.5	1.5	-1.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	3.5	1.2	-0.2	0.3	1.9	-1.4
Pain experienced in last month	1.2	2.0	7.5	-2.7	1.4	0.7	-0.3	0.2
Supplements: Calcium	0.5	0.5	1.6	0.1	1.3	-0.2	0.4	-0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.5	-0.9	-0.7	-0.1	0.7
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.9	0.2	-1.5	-2.2	0.6	1.6
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	5.2	2.3	-0.7	-0.0	0.4	-0.6
Heart disease (siblings)	0.6	0.7	1.5	0.3	-0.1	-1.2	0.9	1.0
Alcohol drinker status: Previous	2.2	2.6	10.0	3.2	-0.8	-0.7	1.0	0.8
Pack years of smoking	1.1	1.6	3.3	-1.8	0.4	1.8	-0.5	1.0
Impedance of whole body	0.3	1.4	3.8	-1.5	0.8	0.0	-0.5	-2.0
Leg fat mass (left)	0.2	0.7	2.0	1.4	-0.7	0.3	-0.5	0.7
Arm predicted mass (left)	0.1	0.5	2.4	0.5	-0.3	1.6	-0.1	0.0