Hub : Genes

PRSS23

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1360 0.0300 2.8e-10 0.127 0.089 0.131 0.108 0.134 3.4e-15 5.5e-11 1.0e-15 5.0e-13 4.7e-16
2 GTEx Adipose Visceral Omentum 0.1700 0.0570 1.5e-03 0.023 NA 0.034 NA 0.046 2.1e-02 NA 7.0e-03 NA 2.1e-03
3 GTEx Artery Aorta 0.2330 0.0650 7.2e-05 0.145 NA 0.102 NA 0.128 2.3e-08 NA 3.1e-06 NA 1.5e-07
4 GTEx Breast Mammary Tissue (Female) 0.0821 0.0746 1.8e-01 0.004 NA -0.007 NA -0.001 2.3e-01 NA 6.0e-01 NA 3.4e-01
5 GTEx Cells Transformed fibroblasts 0.1280 0.0440 1.6e-03 -0.003 NA 0.008 NA -0.002 7.8e-01 NA 7.3e-02 NA 5.2e-01
6 GTEx Pancreas 0.2020 0.0820 6.8e-03 0.023 NA -0.005 NA -0.002 3.8e-02 NA 6.2e-01 NA 4.1e-01
7 GTEx Thyroid 0.1780 0.0390 5.0e-08 0.086 NA 0.126 NA 0.137 4.3e-07 NA 7.2e-10 NA 1.2e-10
8 METSIM Adipose 0.0711 0.0216 6.7e-06 0.058 0.047 0.042 0.048 0.050 4.1e-09 1.4e-07 5.1e-07 8.9e-08 4.7e-08
9 ROSMAP Brain Pre-frontal Cortex 0.1713 0.0360 4.3e-12 0.131 0.128 0.142 0.161 0.141 1.7e-16 3.4e-16 7.5e-18 3.8e-20 1.0e-17
10 YFS Blood 0.0196 0.0088 6.6e-03 0.009 0.002 0.006 0.006 0.010 5.8e-04 4.3e-02 3.4e-03 3.4e-03 2.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 1.8 2.9 5.6 1.9 2.4 -1.4 1.5 1.5 1.4 1.9 1.8 2.1 -0.0
Bipolar Disorder or Schizophrenia 0.4 0.9 2.7 0.7 1.7 -0.8 1.1 -0.0 0.5 1.0 0.8 1.3 0.1
Depressed Affect (Nagel 2018) 2.6 5.4 10.4 2.8 3.0 -1.5 0.7 -0.5 2.6 3.2 2.9 2.8 -0.9
Depression (Nagel 2018) 1.1 1.7 3.7 1.6 1.5 -0.3 0.5 1.0 1.3 1.6 1.9 1.6 0.3
Intelligence (Savage-Jansen 2018) 0.8 2.5 6.5 -2.0 -1.8 0.0 0.1 -0.6 -1.9 -1.6 -1.9 -2.6 -1.1
Neuroticism (Nagel 2018) 4.0 9.4 17.4 4.2 3.7 -1.3 1.5 1.8 3.3 4.0 4.0 3.5 -0.7
Schizophrenia (2018) 0.1 0.3 1.6 -0.7 0.2 0.1 0.3 -1.3 -0.5 -0.3 -0.5 -0.0 0.1
Schizophrenia vs Biploar Disorder 2.0 2.6 9.0 -1.3 -1.7 3.0 1.0 -1.1 -2.0 -1.9 -0.5 -1.4 -0.5
Worry (Nagel 2018) 2.7 5.7 11.2 3.3 3.2 -1.6 0.4 1.5 1.9 2.6 3.2 3.0 0.8
Alzheimer’s Disease (in mother) 0.7 0.8 2.1 -1.2 -1.0 0.5 0.3 0.9 -0.8 -0.7 -1.1 -1.4 -0.3
Alzheimer’s Disease (in father) 0.3 0.3 1.7 0.2 -0.4 0.1 -0.0 -0.8 1.3 0.5 -0.4 -0.1 0.6
Alzheimer’s Disease (including proxy) 0.8 1.2 2.8 -1.2 -1.7 1.2 -0.3 -0.1 -0.2 -0.9 -1.6 -1.6 0.7
Crohns Disease (2017) 0.3 0.6 2.5 -0.4 -0.7 0.1 -0.4 -1.6 -1.5 -0.3 -0.4 -0.1 -0.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.7 -0.4 -1.0 0.8 0.2 -1.0 -0.7 -0.9 -0.7 -0.4 1.3
Ulcerative Colitis (UC) 0.5 0.9 5.2 -0.3 -0.8 0.9 0.4 -0.5 -0.2 -1.1 -0.5 -0.3 2.3
Major Depression (MDD) 0.3 0.4 1.9 -0.3 -0.0 0.2 0.2 0.7 -0.9 -1.4 -0.1 -0.4 -0.3
Reaction Time 0.6 1.1 3.8 0.8 0.4 1.3 -1.3 1.9 0.3 0.5 1.4 1.1 0.7
Verbal and Numeric Reasoning (VNR) 0.1 0.4 0.9 -0.5 -0.9 0.7 -0.4 -0.0 -0.6 -0.5 -0.7 -0.8 -0.1
Breast Cancer 0.6 1.5 4.0 0.5 1.0 -2.0 -1.8 1.6 -0.0 1.0 -0.3 -0.1 -1.8
Ovarian Cancer 0.3 0.4 1.1 -0.2 0.7 -0.8 1.1 0.2 -0.4 0.1 -0.6 -0.7 -0.4
Prostate Cancer 0.3 0.4 3.0 -0.2 0.5 -0.4 -1.7 -0.3 -0.5 0.0 0.2 -0.1 -0.6
Age at First Birth 3.6 5.3 11.7 -2.4 -3.4 2.1 -0.8 1.7 -1.1 -2.6 -2.6 -3.1 1.7
Bipolar Disorder (2011) 1.1 1.1 2.9 0.9 1.0 -1.6 0.8 -0.0 -0.1 1.2 0.9 1.7 -0.7
Body Mass Index (BMI) (2010) 0.9 1.2 3.0 1.7 1.4 -0.3 0.4 0.5 1.2 1.1 1.1 1.5 0.5
Coronary Artery Disease (CAD) 0.9 1.1 2.3 1.4 1.1 -0.5 0.1 0.5 1.1 1.5 1.4 1.3 -0.2
Crohns Disease (2012) 0.2 0.4 1.2 0.4 0.0 -0.4 -1.0 -1.1 -0.7 0.4 0.1 0.3 -0.7
Mean Putamen Volume 0.8 0.9 1.9 1.0 1.4 -1.0 -0.1 -0.6 -0.8 1.1 1.0 1.3 0.4
Fasting Glucose 1.4 1.7 4.9 2.2 1.0 0.7 -0.0 -0.3 0.4 1.2 2.0 2.1 0.4
HbA1C 0.3 0.4 0.8 0.5 0.6 -0.3 0.8 -0.2 0.4 0.4 0.9 0.6 -0.9
HDL Cholesterol 0.4 0.7 3.6 0.0 -0.6 1.9 1.6 0.4 0.5 -0.4 -0.1 -0.0 -0.0
LDL Cholesterol 1.5 2.4 5.0 2.2 1.4 -1.9 0.5 -0.5 1.1 2.2 0.9 2.0 1.5
Lupus 1.3 2.0 4.0 1.7 2.0 -0.0 0.6 0.1 1.6 1.6 1.7 1.3 -1.8
Neuroticism (2016) 0.7 1.0 2.3 1.5 0.8 -0.1 0.5 0.7 1.4 1.5 1.2 0.5 -0.3
Primary Biliary Cirrhosis 1.3 1.9 7.9 -0.9 -1.5 1.1 0.5 0.6 0.1 -1.3 -1.7 -1.3 2.8
Rheumatoid Arthritis 1.5 2.0 3.6 1.9 1.7 -1.1 1.3 0.3 1.6 1.3 1.7 1.6 1.2
Schizophrenia (2014) 0.1 0.3 1.1 -0.3 0.6 0.1 0.5 -1.1 -0.7 -0.0 -0.1 0.7 0.1
Triglycerides 0.9 1.5 4.5 1.1 1.8 -2.1 -1.1 0.8 0.6 1.6 0.8 0.7 -0.7
Type 2 Diabetes (T2D) (2012) 0.4 0.4 1.9 -0.3 0.1 -0.5 0.7 1.4 -0.3 -0.4 -0.8 -0.7 0.6
Ulcerative Colitis 0.4 0.6 1.8 -0.8 -0.4 0.2 -0.1 -0.8 -0.6 -1.2 -1.0 -0.3 1.3
Blood Eosinophil Count 0.2 1.2 2.6 -0.6 -1.0 1.6 -1.4 -0.8 -0.8 -1.6 -0.4 -0.3 1.2
Blood Platelet Count 0.3 3.6 13.1 -0.5 -2.5 3.6 -0.3 1.5 1.2 -2.1 -1.1 -0.9 2.5
Blood Red Count 0.6 5.7 34.6 -0.8 -2.4 5.9 1.4 -0.1 1.1 -2.9 -0.9 -0.9 1.6
Blood White Count 1.0 7.2 25.6 -2.1 -3.1 5.1 0.9 -2.3 -1.1 -3.7 -1.9 -1.7 2.2
Heel T-Score 1.1 8.9 16.6 3.6 3.9 -0.2 2.2 3.7 2.7 3.4 4.1 2.4 -0.9
BMI 0.9 5.0 9.7 2.8 2.3 -1.4 -0.3 -1.9 2.4 3.0 2.3 3.1 1.0
Height 0.2 3.8 8.8 -2.0 -0.4 -1.4 -3.0 0.9 -2.9 -1.2 -1.5 -2.1 -2.4
Waist Hip Ratio (WHR) 0.9 3.9 19.8 -0.9 -2.2 4.5 1.0 -1.9 0.6 -2.3 -0.7 -1.0 1.4
Systolic Blood Pressure 0.2 0.9 2.0 1.2 1.3 -0.4 -1.1 0.0 1.4 0.7 0.7 1.4 -0.0
Smoking Status 1.3 3.1 6.8 1.5 2.6 -0.5 0.6 -2.4 -0.4 1.2 2.4 1.8 -2.0
Allergy or Eczema 0.5 1.2 3.0 0.1 1.5 -1.4 -0.8 -1.7 -1.5 0.1 1.2 -0.4 -0.7
Cardiovascular Disease 0.5 1.5 3.7 1.5 1.9 -0.8 0.6 0.6 0.9 1.0 1.7 1.4 -1.1
Hypothyroidism (self reported) 0.1 0.3 0.7 -0.4 -0.6 -0.6 -0.5 0.6 0.3 0.2 -0.7 -0.8 0.8
Respiratory disease 0.6 1.4 3.2 1.4 1.8 -1.6 1.0 -0.7 0.9 1.3 1.2 0.8 0.2
Type 2 Diabetes (T2D) (2018) 1.0 1.9 4.0 1.3 1.6 0.0 -1.1 -1.5 1.4 1.2 1.5 1.4 2.0
Lung FEV1/FVC ratio 0.3 1.5 5.7 -1.0 -1.8 2.4 -0.1 0.2 -0.1 -1.2 -0.9 0.1 1.7
Lung FVC 0.1 0.5 1.7 -0.0 -0.4 -0.1 0.9 0.7 1.3 -0.2 -0.8 -0.3 1.0
Neuroticism 2.8 6.9 13.0 3.6 3.4 -1.1 -0.2 1.7 2.7 3.1 3.6 3.2 -0.3
Chronotype (morning person) 1.2 2.8 6.7 1.9 1.2 0.1 1.9 -1.2 2.6 2.4 1.8 1.4 -0.7
Hair Pigment 0.0 1.0 2.9 1.2 0.3 -0.0 0.2 1.0 1.7 0.8 0.7 1.7 0.9
Tanning 0.1 0.9 2.4 1.2 0.1 0.8 -1.0 -1.2 0.5 1.2 1.6 0.4 -0.7
Hand grip strength (left) 0.3 0.8 3.1 0.3 0.0 -1.1 1.8 -0.9 1.2 0.6 -0.9 0.5 -0.6
Number of treatments/medications taken 0.6 1.0 5.5 0.7 1.1 -1.2 -0.6 2.3 0.2 0.3 0.2 0.8 0.4
Average weekly spirits intake 0.7 0.9 2.8 0.6 1.7 -1.6 -0.0 0.1 -0.8 0.5 0.8 1.2 -0.5
Sensitivity / hurt feelings 4.2 7.1 15.3 3.9 3.0 -0.7 0.4 2.1 2.8 3.5 3.5 3.1 0.0
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.2 0.3 0.3 -0.2 -1.1 0.5 -0.2 0.1 0.7 0.3 0.8
Hearing difficulty/problems: Yes 0.2 0.4 0.9 -0.9 -0.3 0.2 0.4 -0.4 -0.8 -0.5 -0.9 -0.8 -0.2
Relative age of first facial hair 0.9 1.8 4.0 0.9 1.7 -2.0 1.2 0.6 -0.1 1.5 1.1 1.1 -1.8
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 4.5 -0.5 -1.1 2.1 -0.1 -0.7 -0.9 -1.5 -0.6 -1.1 0.7
Ever used hormone-replacement therapy (HRT) 1.7 2.2 5.1 1.9 2.3 -0.6 -0.3 1.0 1.0 1.7 1.9 1.8 -0.9
Ever had hysterectomy (womb removed) 0.4 0.5 2.6 0.2 0.1 -0.2 -0.6 0.9 0.1 -0.4 -0.2 0.8 1.6
Systolic blood pressure, automated reading 0.5 1.5 3.0 1.5 1.7 -1.1 -0.6 0.7 1.7 1.4 0.5 1.5 0.0
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 7.7 1.3 0.9 1.0 -2.8 -0.8 0.7 0.8 1.6 0.8 -0.8
Angina 0.7 1.0 3.2 0.9 1.8 -0.9 0.6 1.1 0.6 0.8 0.6 1.1 0.9
Medication for hormone replacement therapy 3.8 4.2 8.7 2.7 2.6 0.9 0.6 0.8 3.0 2.4 2.5 2.0 -1.3
Vitamin and mineral supplements 1.6 2.2 7.8 -0.7 0.2 -0.1 2.5 -2.8 -1.1 -0.2 -0.0 -0.9 -2.4
Supplements: Zinc 1.9 2.1 4.4 -1.4 -2.0 1.1 0.8 0.1 -0.2 -2.1 -1.6 -1.5 2.1
Medication: Co-codamol 0.3 0.3 1.1 0.2 0.8 -0.8 0.4 -0.6 0.1 1.1 0.5 -0.2 -0.4
Medication: Metformin 0.9 1.3 2.2 1.3 1.5 -0.3 -0.2 -1.4 1.3 1.0 1.4 1.4 0.4
Diabetes (father) 1.0 1.2 2.6 1.2 1.0 -1.6 -0.6 -0.2 1.3 1.6 0.7 1.4 -0.2
Diabetes (mother) 0.9 1.2 5.1 -0.0 -0.2 1.0 0.7 1.6 0.4 -1.0 -0.4 -0.9 2.3
Severe depression (siblings) 0.5 0.6 2.8 0.5 0.7 0.1 0.1 1.3 -0.3 0.1 0.6 0.2 -1.7
Pack years adult smoking proportion 0.3 0.5 1.5 0.7 0.6 -0.3 -0.3 -0.5 0.2 1.0 0.8 0.8 -1.2
Impedance of leg (right) 1.9 9.3 24.3 -4.0 -2.5 2.2 -0.7 -1.2 -4.9 -4.1 -2.4 -3.8 -1.3
Leg fat-free mass (left) 0.8 4.1 8.3 2.4 2.3 -2.3 -0.1 0.3 2.5 2.9 1.6 2.6 -0.4
Trunk fat percentage 0.2 0.9 6.8 -0.6 -0.4 0.5 -0.7 -2.6 -0.2 -0.2 -0.8 0.1 -0.0
Hand grip strength (right) 0.6 1.5 6.0 0.8 1.2 -2.5 1.0 -1.1 0.6 1.3 0.2 0.8 -1.5
Townsend deprivation index at recruitment 1.2 1.7 9.2 -1.6 -0.1 -1.4 -0.9 0.0 -3.0 -1.0 -0.2 -0.5 -1.2
Current tobacco smoking 0.5 0.8 3.3 -0.6 0.1 -0.8 0.1 -0.9 -1.7 -0.1 -0.0 -0.5 -1.8
Average weekly fortified wine intake 1.6 1.9 5.1 -1.3 -1.3 -0.9 -2.1 -0.1 -0.0 -1.0 -2.2 -1.6 1.2
Maternal smoking around birth 0.4 0.6 3.3 0.5 0.9 0.4 -0.5 -1.8 0.1 0.0 0.5 0.5 -0.7
Fed-up feelings 1.1 2.0 4.2 1.4 2.0 -1.3 0.7 -1.6 1.0 1.6 1.9 1.5 -0.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.4 0.9 1.8 -1.0 -0.6 -0.1 -0.0 1.2 1.8 1.2 -0.3
Relative age voice broke 0.4 0.6 3.0 -0.1 0.8 -1.7 1.2 -0.2 -0.1 0.4 -0.0 0.6 -0.4
Taking other prescription medications 0.8 1.3 3.0 -1.3 -0.0 -0.6 0.8 1.2 -1.7 -1.5 -1.3 -1.3 0.3
Age when periods started (menarche) 0.7 1.7 6.2 1.0 1.5 0.4 1.7 -0.3 -0.5 1.1 1.6 0.6 -2.5
Bilateral oophorectomy (both ovaries removed) 0.4 0.5 1.2 0.6 0.8 -0.6 1.1 0.1 0.9 0.5 0.2 1.0 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.4 6.0 1.9 1.3 1.1 1.0 1.6 1.9 1.4 2.5 1.1 0.3
Tinnitus: Yes, but not now, but have in the past 2.8 3.0 8.3 2.2 1.8 0.6 -1.9 -0.9 -0.0 1.6 2.9 2.1 -1.2
Qualifications: CSEs or equivalent 0.3 0.4 2.1 0.2 0.5 0.4 1.0 1.5 0.4 0.5 0.6 -0.1 -0.1
Serious illness, injury or assault to yourself 0.4 0.5 1.2 0.8 0.6 0.3 1.0 0.3 1.1 0.6 1.0 0.4 -0.1
High blood pressure 0.3 0.9 2.2 1.5 1.0 0.3 -0.2 0.6 1.4 0.6 1.3 1.1 0.3
Hayfever, allergic rhinitis or eczema 0.4 1.0 3.9 -0.2 1.1 -0.5 0.1 -1.1 -2.0 -0.7 1.0 -0.8 -1.0
Multivitamins +/- minerals 1.5 1.9 8.0 0.3 -0.5 0.9 -2.1 2.8 1.0 -0.1 -0.1 0.1 2.1
Stomach or abdominal pain in last month 2.4 3.0 7.2 1.7 2.2 -2.4 0.2 -0.7 0.8 2.7 1.8 1.4 -1.4
Supplements: Glucosamine 2.8 3.6 7.6 2.5 2.2 -1.5 0.2 1.4 1.6 2.8 2.2 2.4 -0.7
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 4.1 -0.2 -0.4 1.4 2.0 -1.6 0.5 -0.2 -0.1 -0.0 -0.0
Medication: Atenolol 2.9 3.7 6.7 2.2 2.4 -1.6 2.1 -0.8 0.8 2.6 1.9 1.8 -1.9
Medication: Levothyroxine sodium 0.4 0.6 2.1 -0.8 -0.6 -0.6 1.5 0.3 -0.0 -0.1 -1.3 -0.8 0.6
Sitting height 0.3 2.2 9.2 -1.4 0.4 -3.0 -1.9 0.1 -1.6 -0.8 -1.1 -1.2 -0.8
Chronic bronchitis/emphysema (father) 0.5 0.6 1.6 -0.4 -0.2 -0.1 -1.3 -0.3 -1.3 -0.3 -0.5 -1.1 -0.8
High blood pressure (mother) 0.0 0.1 0.3 -0.0 0.2 0.1 0.3 0.4 0.5 -0.1 -0.0 -0.0 0.2
Body mass index (BMI) 1.1 4.7 10.9 3.0 1.9 -1.0 0.4 -0.7 3.3 3.1 1.8 2.9 0.3
Impedance of leg (left) 2.3 11.0 29.3 -4.6 -2.9 1.6 -1.1 -1.7 -5.4 -4.3 -3.0 -4.0 -1.5
Leg predicted mass (left) 0.7 3.8 7.7 2.3 2.2 -2.3 -0.0 0.4 2.5 2.8 1.5 2.5 -0.4
Trunk fat mass 0.1 0.6 3.5 0.3 0.5 -0.5 -0.7 -1.9 0.5 0.8 -0.1 0.9 -0.2
Waist circumference 0.3 1.0 2.7 1.1 0.5 0.6 -0.3 -1.3 1.6 0.8 0.6 1.5 0.6
Number of incorrect matches in round 0.2 0.3 1.6 0.2 0.1 0.6 -0.4 -0.1 0.1 -0.2 0.0 0.8 1.3
Past tobacco smoking 1.5 2.8 11.8 -1.4 -2.2 -0.2 0.6 3.4 0.4 -1.1 -2.2 -1.2 1.4
Alcohol usually taken with meals 0.2 0.4 1.2 -0.5 -0.7 -0.6 -0.2 -0.5 0.9 0.2 -1.1 -0.1 0.5
Nervous feelings 2.4 4.5 9.8 3.1 3.0 -0.9 -0.7 1.0 1.6 2.2 3.0 2.5 1.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 2.1 0.6 0.7 -0.3 -0.2 0.8 -0.3 0.0 0.8 0.3 1.4
Hearing difficulty/problems with background noise 2.1 3.3 7.7 -2.5 -1.6 0.3 -0.7 -1.9 -2.3 -2.1 -1.7 -2.8 -0.2
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 -0.3 -0.7 0.5 0.1 0.2 -0.8 -0.6 0.1 -0.7 -0.2
Had menopause 0.7 0.9 2.1 0.6 1.2 -1.0 -1.5 0.3 -0.3 1.1 0.5 0.6 -1.4
Had other major operations 0.8 1.0 6.5 -0.5 -0.2 0.1 0.0 2.5 0.3 -0.2 -0.9 -0.9 1.1
Forced vital capacity (FVC) 0.3 1.2 2.8 -1.7 -0.7 -1.3 0.7 -0.2 -1.5 -1.2 -1.4 -1.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 1.5 3.5 8.2 2.6 1.0 2.0 1.4 1.3 2.5 1.4 2.9 1.6 1.0
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.1 0.7 0.6 0.2 -0.4 0.4 1.1 0.8 0.7 0.3 -0.3
Qualifications: None of the above 1.5 3.2 7.7 2.5 2.2 -0.5 0.2 -0.3 1.8 2.2 2.8 2.1 -0.7
Financial difficulties in last 2 years 0.7 0.9 4.0 -0.8 -0.3 -0.8 -0.7 -2.0 -1.4 -0.4 0.2 -0.5 -0.9
Mouth/teeth dental problems 2.0 3.1 6.8 -1.8 -2.6 2.2 -0.8 0.1 -0.9 -2.5 -2.1 -1.4 1.1
Heart attack 0.2 0.2 1.3 -0.1 0.4 -0.1 0.5 1.1 0.3 -0.4 -0.3 -0.0 0.6
Allergy 0.5 1.0 3.1 -0.4 -1.7 0.7 0.0 0.5 1.8 -0.4 -1.2 0.4 1.4
Pain all over the body in last month 0.4 0.4 1.7 -0.2 -0.6 0.7 -0.7 1.3 -0.7 -0.5 -0.4 -0.2 0.6
Diabetes (self-reported) 0.8 1.3 3.2 1.1 1.0 0.5 -1.6 -0.9 1.2 0.5 1.0 1.2 1.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.7 -0.3 -0.0 -0.0 0.5 0.6 -0.9 -0.7 -0.2 -0.0 0.5
Medication: Ramipril 0.6 0.7 4.4 0.1 0.5 0.1 -0.7 -1.4 0.1 0.4 0.2 -0.2 -2.1
Medication: Simvastatin 0.4 0.6 1.6 1.0 0.9 -0.2 -1.3 0.2 0.6 0.9 0.5 1.2 -0.1
Fluid intelligence score 0.8 1.7 3.2 -1.7 -1.4 0.4 0.9 0.1 -1.7 -1.4 -1.8 -1.7 -0.8
Illnesses of siblings 2.1 2.9 6.2 -2.5 -1.7 0.9 0.4 -0.1 -2.4 -2.2 -1.8 -2.4 0.2
Neuroticism score 2.4 5.0 11.7 3.0 3.4 -1.0 -0.0 0.6 1.7 2.5 3.4 2.7 -0.4
Weight 0.6 2.9 6.4 2.0 2.0 -1.8 -0.4 -0.5 1.8 2.5 1.3 2.3 -0.9
Impedance of arm (right) 3.3 15.6 32.2 -5.2 -4.5 3.8 -1.1 -1.1 -4.9 -5.7 -3.9 -4.6 0.4
Arm fat percentage (right) 0.2 0.8 2.7 0.6 -0.1 1.0 -0.4 -1.6 1.6 0.4 0.0 1.0 0.7
Trunk fat-free mass 1.1 6.1 10.4 2.9 3.2 -3.2 -0.3 1.4 2.0 3.2 2.4 2.9 -1.3
Hip circumference 0.6 2.8 5.6 1.6 2.1 -2.2 -0.5 -0.6 1.1 2.4 1.3 2.4 -0.9
Time employed in main current job 1.0 1.2 5.5 1.3 0.3 0.8 -0.3 1.3 1.1 0.4 1.0 0.4 2.4
Alcohol intake versus 10 years previously 0.4 0.6 1.8 0.5 1.1 -1.3 0.4 1.3 -0.5 0.4 0.6 -0.5 0.3
Father’s age at death 1.7 2.2 3.9 -1.7 -1.8 0.9 0.9 -0.9 -1.8 -2.0 -1.7 -1.9 0.6
Worrier / anxious feelings 2.1 3.9 7.7 2.8 2.6 -1.2 1.3 1.4 1.3 2.2 2.6 2.4 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.4 0.2 0.2 -0.3 -1.0 0.3 -0.1 -0.3 -0.1 -0.1 1.2
Falls in the last year 0.2 0.3 1.1 -0.2 -1.0 0.8 0.5 0.2 -0.3 -0.2 -0.6 -0.5 0.5
Hair/balding pattern: Pattern 3 0.6 0.9 3.0 -0.9 -0.6 -1.7 0.5 -1.0 -0.6 -0.3 -1.6 -0.6 0.6
Number of live births 0.5 0.8 1.6 -1.3 -1.2 0.7 -0.4 -1.0 -0.5 -1.1 -0.7 -1.1 -0.0
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 3.4 -1.9 -1.2 -0.7 0.9 -0.2 -1.1 -1.2 -1.6 -1.1 0.6
Pulse rate 0.5 0.8 2.7 -0.8 -0.6 0.8 -0.9 0.1 -1.6 -1.3 -0.5 -0.9 0.2
Happiness 0.5 0.7 2.1 -0.9 0.1 -1.4 1.2 0.1 -0.6 -0.4 -1.2 -0.4 -0.4
Noisy workplace 1.4 1.8 5.0 1.1 2.2 -1.4 1.7 -0.0 0.5 1.3 1.2 1.3 -1.2
Qualifications: A levels/AS levels or equivalent 3.1 6.8 12.5 -2.9 -3.5 2.9 0.6 -2.4 -1.4 -3.5 -3.0 -2.6 1.8
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.7 0.0 0.7 0.3 -0.5 0.4 0.5 0.6 0.2 -0.1
Mouth/teeth dental problems: Dentures 4.4 7.5 17.3 3.4 3.5 -2.0 1.8 -0.2 3.2 4.2 2.9 2.7 -0.6
Asthma 0.3 0.6 2.5 0.7 1.2 -0.3 0.7 -0.5 -0.4 0.6 0.7 0.4 -1.6
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 2.8 -0.1 0.7 -1.7 1.4 1.2 -0.6 0.0 -0.2 -0.1 -0.1
Medication: Cholesterol lowering 2.4 3.7 8.4 2.9 2.5 -0.8 -0.7 0.6 1.7 2.6 2.6 2.2 -0.3
Depression (self-reported) 0.7 0.8 2.7 -0.8 -0.5 0.4 0.2 1.2 -0.0 -1.6 -1.0 -0.8 1.2
Medication: Lansoprazole 1.7 2.0 4.1 -2.0 -0.8 0.6 -0.1 0.6 -1.9 -1.9 -1.9 -1.8 0.3
Prospective memory result 2.4 3.0 7.7 2.3 2.0 0.1 -0.4 -0.5 1.4 1.9 2.8 2.5 -0.8
Lung cancer (father) 1.4 1.6 4.8 1.2 2.2 -0.9 -1.6 1.2 -0.2 1.0 1.4 1.0 -1.0
Illnesses of mother 0.7 0.9 1.6 -1.1 -1.2 -0.1 -1.0 -0.9 -0.9 -1.0 -1.3 -0.8 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.7 -0.9 -0.6 -0.9 1.2 -0.3 -0.4 -0.7 -0.8 -0.1 1.3
Pulse wave Arterial Stiffness index 4.5 5.3 13.0 2.9 3.0 -1.6 -0.3 0.5 1.8 3.6 2.6 2.4 -1.8
Impedance of arm (left) 4.0 18.4 36.2 -5.6 -5.0 4.1 -0.6 -1.9 -5.1 -6.0 -4.4 -5.0 0.8
Arm fat mass (right) 0.3 1.2 4.0 1.4 0.8 -0.1 -0.1 -0.9 2.0 1.3 0.6 1.6 0.1
Trunk predicted mass 1.0 5.6 9.7 2.8 3.0 -3.1 -0.2 1.5 2.0 3.1 2.3 2.7 -1.1
Standing height 0.3 2.8 10.4 -1.7 0.3 -1.8 -1.5 0.5 -3.2 -1.0 -0.9 -1.0 -2.4
Length of working week for main job 1.4 1.6 4.3 1.1 1.4 -0.7 2.1 0.0 -0.0 1.3 1.9 0.6 -1.3
Exposure to tobacco smoke at home 0.4 0.5 3.7 -0.2 -0.6 1.9 -0.2 -0.3 -0.2 -0.7 -0.0 -0.4 0.1
Breastfed as a baby 0.2 0.2 1.5 -0.3 -0.1 -0.2 -1.2 -0.3 -0.2 -0.3 -0.3 0.3 -0.4
Tense / ‘highly strung’ 0.9 1.6 3.9 1.8 2.0 -0.6 -0.8 1.0 0.6 0.9 1.6 1.6 0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 3.0 -0.8 -0.1 0.1 -1.1 -0.2 -1.7 -1.3 -0.1 -0.6 -0.8
Hair/balding pattern: Pattern 4 0.5 1.1 6.6 -0.7 0.5 -2.6 1.4 -0.7 -0.8 0.5 -0.2 -0.6 -0.3
Birth weight of first child 0.6 1.1 2.9 -1.5 -1.3 -0.1 -0.1 0.2 -1.7 -1.2 -1.4 -0.6 0.6
Peak expiratory flow (PEF) 2.7 6.3 14.6 -3.2 -3.8 2.1 0.9 -0.7 -1.8 -2.9 -3.2 -3.2 0.7
Pulse wave reflection index 2.6 3.2 6.9 1.7 2.3 -1.7 1.3 -0.4 1.2 2.6 1.9 1.5 -2.3
Ever highly irritable/argumentative for 2 days 3.6 4.4 9.2 3.0 2.1 -0.7 0.7 -1.4 1.8 2.7 2.8 2.9 -1.0
Loud music exposure frequency 1.0 1.1 4.3 -0.8 -0.4 1.6 2.1 -0.9 -0.4 -1.2 0.0 -1.0 0.6
Qualifications: O levels/GCSEs or equivalent 4.9 7.8 13.9 -3.7 -3.2 1.3 -0.3 -1.5 -3.1 -3.6 -3.7 -3.7 -0.7
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.2 -0.3 -0.1 -0.0 -1.0 -1.2 -0.6 -0.3 0.1 0.2 -1.5
Blood clot in the leg (DVT) 0.6 0.7 2.1 -0.6 -0.9 0.3 0.4 1.4 -0.2 -0.3 -1.0 -0.9 1.4
Medication: Paracetamol 0.7 1.2 7.3 -0.6 0.4 -1.0 1.3 0.2 -2.7 -1.0 0.1 -0.5 -0.4
Headache pain in last month 0.2 0.4 1.3 0.8 0.9 -0.2 0.1 0.7 -0.0 0.3 1.2 0.6 0.7
Medication for cholesterol, blood pressure or diabetes 1.4 2.3 5.3 -2.3 -1.9 0.5 1.0 -0.1 -1.5 -1.9 -1.9 -1.8 -0.0
Glaucoma (self-reported) 3.5 4.1 7.4 -2.1 -2.6 2.2 -0.5 -0.8 -2.0 -2.7 -1.9 -2.7 1.4
Gout (self-reported) 0.2 0.3 1.3 0.7 -0.3 0.6 1.1 0.7 -0.1 0.2 0.2 0.5 -0.2
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.2 -0.7 -0.7 -0.8 -0.2 1.0 0.1 -0.0 -1.1 -1.0 1.0
Medication: Amlodipine 0.2 0.3 1.4 0.3 0.6 -0.8 0.1 0.7 -0.3 0.0 -0.2 0.3 -1.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.3 0.1 0.6 -0.6 1.1 -0.3 -0.7 0.8 0.2 -0.1 -1.1
Birth weight 0.1 0.3 1.0 -0.7 0.3 -0.6 -1.0 0.3 -0.6 -0.3 -0.5 -0.2 -0.5
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.6 0.5 0.5 -0.8 0.2 -0.7 -0.2 0.6 0.6 0.8 -0.8
High blood pressure (siblings) 1.0 1.5 4.0 1.9 1.1 0.1 -0.7 0.3 2.0 1.2 1.4 1.4 -0.3
Forced vital capacity (FVC), Best measure 0.3 1.1 1.8 -1.4 -0.7 -1.2 0.9 -0.4 -1.1 -1.3 -1.2 -0.7 1.0
Body fat percentage 0.2 0.7 5.3 0.0 -0.1 0.5 -0.6 -2.3 0.5 0.2 -0.4 0.5 -0.0
Leg fat percentage (right) 0.4 1.3 2.5 1.5 1.1 0.1 -0.3 -1.5 1.5 1.3 0.9 1.6 -0.1
Arm fat-free mass (right) 1.0 5.0 10.7 2.4 2.9 -3.3 0.2 0.3 1.7 3.1 1.9 2.5 -1.6
Exposure to tobacco smoke outside home 0.3 0.4 2.3 0.0 0.4 -0.4 0.6 -1.5 0.0 0.1 0.4 0.6 0.1
Comparative body size at age 10 0.7 2.0 10.1 0.5 -1.4 1.8 -3.2 -0.2 1.6 0.1 -0.4 1.0 1.0
Number of full brothers 0.6 0.7 2.0 -0.8 -1.3 1.4 0.5 -0.3 -0.7 -0.9 -0.4 -0.5 -1.1
Worry too long after embarrassment 0.2 0.3 1.6 0.1 -0.0 -0.3 -1.3 0.5 -0.8 -0.3 0.3 -0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.6 -1.0 -1.0 1.1 -1.3 0.2 -1.5 -1.6 -0.8 -0.7 0.2
Wheeze or whistling in the chest in last year 0.5 0.9 4.2 0.1 1.0 -1.1 0.4 2.0 -0.7 0.4 -0.1 -0.6 -1.2
Number of children fathered 2.3 2.6 5.5 1.8 1.6 1.2 1.8 -1.8 2.3 1.0 1.2 2.0 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 6.2 -0.6 -0.9 0.9 -2.5 0.9 -0.5 -1.2 -0.9 -0.5 1.0
Age at first live birth 0.5 0.8 1.7 -0.8 -1.2 0.8 -0.5 0.7 -0.2 -1.1 -1.3 -1.0 0.9
Pulse wave peak to peak time 3.9 4.6 11.6 -2.9 -2.7 1.1 0.3 -0.5 -2.1 -3.4 -2.4 -2.3 1.5
Health satisfaction 1.0 1.3 4.6 1.2 2.1 -0.8 0.7 0.6 -0.3 1.2 1.5 0.9 -0.7
Shortness of breath walking on level ground 1.1 1.3 3.5 1.1 1.9 -1.8 1.2 0.1 -0.1 0.7 1.1 1.2 -0.1
Qualifications: College or University degree 0.8 2.4 5.7 -1.7 -2.4 1.0 1.4 0.3 -0.8 -2.0 -2.1 -1.1 1.3
Eye problems/disorders: None of the above 0.6 0.7 1.9 0.3 1.0 -1.4 0.4 -0.4 0.8 0.8 0.1 0.7 -1.3
Mouth/teeth dental problems: Loose teeth 0.5 0.6 3.9 -0.2 0.1 -1.1 -2.0 -0.1 -0.6 -0.2 0.2 0.1 0.7
Emphysema/chronic bronchitis 0.1 0.1 0.2 0.1 0.2 0.1 -0.3 0.1 -0.3 -0.4 0.3 -0.4 0.4
Medication for pain relief, constipation, heartburn 0.5 0.9 3.4 -0.7 -1.8 1.4 -1.1 -0.6 0.3 -0.2 -0.5 -0.9 0.7
Neck or shoulder pain in last month 0.3 0.4 1.2 0.8 1.0 -0.1 -0.7 -0.2 -0.2 0.6 1.1 0.7 0.2
Medication: Blood pressure 0.4 0.7 1.5 1.2 0.7 0.2 -1.2 -1.0 0.8 0.7 0.8 1.1 0.3
Angina (self-reported) 0.8 1.0 3.2 1.0 1.8 -0.8 0.7 1.3 0.6 0.7 0.6 1.1 0.8
Migraine (self-reported) 0.7 0.8 3.5 -0.6 0.1 -0.0 1.7 -0.4 -1.9 -0.6 -0.5 0.2 -0.8
Medication: Ibuprofen 0.5 0.6 2.7 0.2 0.6 -1.6 1.4 0.6 0.2 0.4 0.2 0.2 0.1
Medication: Allopurinol 0.7 1.0 3.2 -0.4 -1.3 1.8 1.5 0.0 0.1 -1.1 -1.1 -0.5 -0.0
Medication: Omeprazole 0.3 0.3 1.4 0.5 0.7 0.6 -0.6 -0.4 -0.1 0.1 1.2 -0.0 0.5
Medication: Seretide 50 evohaler 0.5 0.6 3.5 -0.4 -0.9 0.5 1.9 -0.0 -0.2 -0.6 -0.6 -0.4 0.6
Mean time to correctly identify matches 0.9 1.7 6.5 1.1 0.3 1.4 -1.8 2.6 0.8 0.4 1.2 0.8 1.0
Heart disease (mother) 1.1 1.3 4.3 0.4 1.4 -2.1 1.3 1.3 -0.5 0.5 0.5 0.0 -1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.1 -0.8 -0.8 -0.1 0.6 1.2 -1.4 -0.1 -1.0 -1.1 -0.6
Whole body fat mass 0.2 0.9 2.8 0.8 0.8 -0.5 -0.6 -1.7 1.0 1.0 0.3 1.2 -0.3
Leg fat mass (right) 0.5 2.0 3.8 1.8 1.6 -1.1 -0.2 -1.2 1.7 2.0 1.0 1.9 -0.6
Arm predicted mass (right) 1.1 5.4 12.6 2.5 3.0 -3.5 0.2 0.5 1.7 3.3 2.0 2.5 -1.4
Pulse rate, automated reading 1.6 5.1 9.3 -2.7 -2.9 1.8 -1.8 -0.0 -2.7 -3.0 -2.4 -2.6 -0.1
Alcohol intake frequency. 0.3 0.6 4.0 0.6 0.7 -0.5 -0.3 2.0 0.3 0.7 0.3 0.7 -0.0
Comparative height size at age 10 0.2 1.3 4.5 0.6 1.3 -1.2 -1.7 0.5 -0.3 0.9 1.0 0.4 -2.1
Number of full sisters 0.3 0.4 1.4 -0.4 -0.1 0.2 0.3 0.6 -1.2 -0.8 0.0 -0.2 -1.1
Suffer from ‘nerves’ 0.6 1.0 3.2 1.0 1.4 -0.7 0.5 1.0 0.0 0.4 1.2 0.6 1.8
Overall health rating 0.3 0.6 1.8 1.0 1.3 -0.2 0.2 1.3 0.3 0.4 1.0 0.6 0.0
Chest pain or discomfort 0.6 0.8 4.1 0.3 1.2 -1.4 -0.1 2.0 0.1 0.3 -0.2 0.3 0.5
Had major operations 0.4 0.4 1.7 -0.7 -0.2 -0.4 0.4 -0.2 -1.3 -0.6 -0.5 -1.1 0.3
Age at last live birth 0.2 0.3 0.7 -0.4 -0.8 0.1 -0.0 0.7 0.3 -0.2 -0.5 -0.7 -0.6
Family relationship satisfaction 0.2 0.3 1.4 0.2 0.3 -0.4 0.1 -0.8 0.1 0.2 0.2 -0.2 -1.2
Leg pain on walking 2.6 3.2 6.9 2.3 2.0 -1.0 1.1 1.4 1.4 2.1 2.4 2.6 -0.2
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.7 0.6 0.4 0.6 0.1 0.9 -0.2 0.1 0.2 -0.9 0.2
Commuting to job workplace: Car/motor vehicle 3.0 3.5 7.0 2.6 2.2 -0.6 -0.0 1.7 0.9 2.2 2.4 1.8 -2.2
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 3.6 -0.0 -1.1 1.9 -1.3 0.5 0.9 -0.8 -0.8 0.3 1.4
Medication: Aspirin 1.0 1.3 3.1 1.6 1.8 -0.3 -0.2 1.5 0.8 0.8 0.8 1.8 -0.4
Supplements: Vitamin C 0.5 0.5 3.7 0.2 -0.3 0.6 -0.8 1.9 0.6 0.2 0.3 0.0 0.3
Knee pain experienced in last month 0.5 0.7 5.4 0.4 0.4 0.2 -0.7 -2.3 -0.0 0.1 0.9 0.1 -0.4
Hypertension (Self-reported) 0.3 0.8 2.1 1.4 0.9 0.2 -0.2 0.6 1.4 0.5 1.2 1.1 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 3.1 -0.6 -0.6 1.8 1.0 -1.0 -0.3 -1.3 0.2 -0.5 1.3
Illnesses of father: Heart disease 0.7 1.0 3.6 0.7 -0.4 0.4 -1.5 -0.6 1.9 0.3 -0.2 0.8 1.4
Illnesses of siblings: Diabetes 0.5 0.6 2.1 0.1 -0.8 0.7 -1.0 -1.5 1.2 -0.4 -0.5 0.1 0.3
Smoking status: Previous 1.8 2.6 9.2 1.3 2.3 -0.5 -0.5 -3.0 0.1 1.4 1.8 1.5 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.7 -1.5 -0.4 -1.0 0.0 -1.9 -1.9 -0.8 -0.9 -0.6 -1.2
Whole body fat-free mass 1.0 5.5 10.4 2.7 2.9 -3.1 -0.2 0.8 2.2 3.2 2.1 2.8 -1.1
Leg fat-free mass (right) 0.7 3.7 7.5 2.1 2.1 -2.7 -0.0 0.1 2.3 2.7 1.3 2.5 -0.5
Arm fat percentage (left) 0.2 0.9 4.0 0.4 -0.3 1.2 0.1 -2.0 1.5 0.2 -0.2 0.7 0.8
Average weekly red wine intake 1.0 1.5 4.4 -1.3 -1.1 -0.1 -0.9 -2.1 -0.2 -1.5 -1.6 -1.4 0.4
Handedness (chirality/laterality): Left-handed 0.7 0.8 2.6 1.4 0.9 -0.5 -0.2 -0.1 1.6 1.0 0.6 1.1 0.5
Mood swings 2.5 4.5 8.8 2.9 2.8 0.2 -0.1 -0.6 2.2 2.5 3.0 2.5 -1.4
Loneliness, isolation 0.9 1.2 3.4 1.1 1.8 -0.9 -0.1 0.4 0.8 1.4 1.5 1.3 0.5
Long-standing illness, disability or infirmity 0.3 0.4 1.3 -0.2 -0.0 0.2 -0.7 0.2 -0.3 -1.1 -0.8 -0.8 1.2
Ever had bowel cancer screening 0.5 0.6 1.5 1.2 0.7 0.1 0.9 0.5 -0.4 0.5 1.0 0.9 -0.7
Diabetes diagnosed by doctor 1.2 1.9 3.3 1.3 1.4 0.7 -1.7 -1.8 1.3 1.0 1.6 1.5 1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.6 0.4 0.4 -0.2 1.3 -1.2 0.6 0.7 0.6 -0.1 -0.3
Friendships satisfaction 0.8 0.9 1.6 1.1 0.9 -1.2 -0.8 0.2 1.1 1.3 0.8 0.8 -0.9
Qualifications: nursing, teaching 0.3 0.4 0.9 -0.6 -0.7 0.4 -0.3 -1.0 -0.7 -0.5 -0.9 -0.4 0.2
Commuting to job workplace: Walk 1.0 1.1 2.0 -1.4 -1.2 -0.4 -1.0 -1.3 -0.4 -0.9 -1.4 -0.9 1.0
Eye problems/disorders: Cataract 0.7 0.8 2.7 1.0 0.1 0.7 0.2 1.0 0.6 0.0 0.8 1.1 1.6
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 3.9 -1.5 -0.6 -0.4 -0.3 -0.4 -2.0 -0.7 -0.9 -1.5 -0.4
Medication for cholesterol 0.7 1.1 5.2 -1.0 -0.8 -1.2 0.7 -2.3 -0.9 0.1 -0.6 -0.8 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.8 2.2 5.1 1.5 0.9 -0.3 -1.8 -0.9 2.3 1.8 0.9 1.5 -1.7
Back pain experienced in last month 0.5 0.7 2.7 0.4 0.8 0.3 -1.6 -1.0 -0.8 -0.1 1.1 0.4 -0.3
Mineral and other dietary supplements 1.8 2.4 4.0 -2.0 -1.6 1.8 0.5 -1.2 -1.6 -1.9 -1.4 -2.0 -0.7
Breast cancer (self-reported) 2.1 2.5 8.3 -1.6 -1.1 -0.2 -1.6 2.9 -1.2 -1.5 -1.6 -1.4 1.2
Asthma (self-reported) 0.3 0.6 1.6 0.9 1.3 -0.1 0.5 -0.3 -0.1 0.6 0.8 0.4 -1.2
Osteoporosis (self-reported) 1.2 1.4 5.9 -0.6 0.1 -0.9 -0.6 2.0 -1.5 -0.3 -0.6 -0.7 -2.4
Osteoarthritis (self-reported) 0.7 0.9 2.2 0.4 1.0 -1.4 1.1 0.5 -0.5 1.1 0.4 -0.1 -1.5
Medication: Aspirin 1.6 2.0 5.1 2.1 2.1 -0.2 0.4 0.8 1.5 1.1 1.4 2.2 -0.3
Medication: Gliclazide 1.6 1.9 5.5 1.6 1.4 0.5 0.5 -0.1 2.0 0.4 1.4 1.4 2.3
Illnesses of father: None of the above (group 1) 0.3 0.4 1.5 -0.1 0.0 0.8 1.2 0.5 -0.3 -0.2 0.7 -0.7 0.6
Smoking status: Current 0.4 0.7 2.7 -0.3 0.5 -0.6 0.0 -0.6 -1.6 0.1 0.3 -0.4 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 4.0 0.2 -1.0 0.5 2.0 0.7 1.8 0.0 -0.2 0.6 1.8
Whole body water mass 0.9 5.4 10.2 2.7 2.9 -3.0 -0.1 0.7 2.1 3.2 2.2 2.8 -1.2
Leg predicted mass (right) 0.7 3.8 7.7 2.1 2.1 -2.7 -0.1 0.2 2.2 2.8 1.3 2.5 -0.5
Arm fat mass (left) 0.2 1.0 3.1 1.2 0.5 0.0 -0.1 -1.2 1.8 1.1 0.5 1.3 0.2
Number of self-reported non-cancer illnesses 0.6 1.0 8.2 0.5 1.0 -0.5 0.4 2.9 0.2 0.0 -0.0 -0.3 0.3
Average weekly champagne plus white wine intake 0.3 0.4 1.7 -0.4 0.5 -0.6 -0.1 1.3 -0.5 0.4 -0.1 0.1 -1.2
Miserableness 1.4 2.4 4.5 1.5 2.0 -1.7 1.2 0.9 1.6 2.1 1.6 1.4 -1.3
Guilty feelings 1.4 2.1 5.5 2.0 1.7 -0.5 0.2 2.3 1.1 1.2 1.7 1.6 0.3
Wears glasses or contact lenses 4.5 5.2 11.8 3.4 2.7 -1.0 -0.7 1.4 2.5 2.9 2.4 3.0 0.0
Ever taken oral contraceptive pill 0.7 0.8 2.0 -1.4 -1.1 -0.1 -0.2 -0.3 -0.8 -0.9 -1.2 -0.9 0.7
Hearing aid user 1.4 1.6 3.4 1.4 1.6 -1.1 0.5 -1.8 0.9 1.7 1.0 1.3 0.4
Mother’s age at death 0.3 0.3 1.0 -0.3 -0.2 -0.5 0.4 1.0 -1.0 0.3 -0.7 -0.4 0.3
Financial situation satisfaction 0.5 0.6 1.9 -0.6 0.4 -1.2 0.9 -0.6 -0.4 0.2 -0.1 -0.6 -1.4
Tinnitus: Yes, now most or all of the time 2.3 2.7 8.3 -2.1 -2.2 -0.4 -0.5 -0.6 -0.7 -1.5 -2.9 -2.0 1.2
Commuting to job workplace: Public transport 2.5 3.0 8.2 -2.3 -1.5 0.7 -0.2 -1.2 -2.9 -2.3 -1.6 -2.1 0.4
Eye problems/disorders: Glaucoma 2.5 2.9 5.7 -1.6 -1.9 1.7 -0.6 -1.9 -2.4 -1.9 -1.3 -2.3 0.2
Medication: Blood pressure 0.2 0.4 1.5 0.2 -0.0 1.2 -0.4 1.0 0.6 -0.7 0.5 0.4 -0.1
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.4 0.1 0.8 -1.0 -0.1 -0.4 -0.3 0.8 0.4 0.6 -1.2
Supplements: Fish oil (including cod liver oil) 3.2 4.1 7.5 2.7 2.2 -2.2 -0.4 1.5 2.5 2.7 2.0 2.1 0.3
High cholesterol (Self-reported) 1.1 2.0 4.2 1.4 2.0 -1.9 -0.3 1.6 0.9 1.8 0.8 1.4 -0.5
Medication: Bendroflumethiazide 0.5 0.8 2.5 -0.4 -1.1 1.4 -0.0 1.6 0.1 -1.3 -0.7 -0.1 0.6
Medication: Paracetamol 0.9 1.4 3.9 0.7 1.6 -2.0 1.6 0.1 -1.3 0.5 1.2 0.8 0.1
Medication: Lisinopril 1.1 1.4 4.1 -0.8 -1.3 1.9 -0.4 0.0 -0.5 -1.5 -0.2 -1.0 2.0
Medication: Atorvastatin 1.1 1.4 3.9 1.3 2.0 -1.0 -0.4 1.2 1.5 1.4 0.8 0.8 -0.1
Illnesses of father: High blood pressure 0.9 1.1 5.4 0.9 0.3 2.3 0.4 -0.8 0.4 0.0 1.0 0.7 -1.4
Alcohol drinker status: Never 0.7 0.8 1.7 -0.9 -1.1 0.4 -0.2 1.1 0.6 -0.9 -1.3 -0.7 1.3
Ever smoked 1.2 2.0 15.8 0.3 0.9 0.2 -0.2 -4.0 -0.9 -0.0 1.2 0.3 -1.0
Basal metabolic rate 0.9 4.9 9.3 2.6 2.8 -2.7 -0.1 0.4 2.2 3.0 2.0 2.8 -1.0
Leg fat percentage (left) 0.4 1.4 3.0 1.3 1.0 -0.5 -0.6 -1.7 1.5 1.5 0.7 1.7 -0.4
Arm fat-free mass (left) 1.2 6.2 11.8 2.7 3.1 -3.4 -0.4 0.7 2.1 3.4 2.3 2.9 -1.7
Number of operations (self-reported) 0.5 0.7 1.7 -0.8 -0.7 0.5 0.4 0.6 -1.1 -0.7 -1.3 -0.9 1.0
Average weekly beer plus cider intake 1.5 2.1 6.5 -1.6 -0.8 0.7 -0.2 1.0 -2.6 -1.9 -1.0 -2.1 -0.9
Irritability 1.2 2.1 5.8 2.1 1.7 0.3 0.2 0.1 1.3 1.8 2.4 1.6 -0.6
Risk taking 0.1 0.2 1.3 -0.0 0.5 -0.2 0.1 -0.4 -0.0 0.5 0.4 0.2 -1.2
Ever had prostate specific antigen (PSA) test 0.4 0.4 1.9 0.4 0.3 -0.2 0.0 -1.1 0.2 0.6 0.3 0.6 -1.4
Fractured/broken bones in last 5 years 0.4 0.6 1.8 0.6 0.4 0.9 -0.6 -1.4 0.3 0.3 1.3 0.5 -0.3
Age started oral contraceptive pill 1.0 1.2 3.1 -1.6 -0.9 -1.1 0.1 0.3 -1.1 -1.3 -1.8 -1.0 0.5
Diastolic blood pressure, automated reading 0.2 0.5 2.1 -0.6 -0.8 -0.1 -0.0 0.7 0.9 -0.7 -1.4 -0.3 0.8
Ever depressed for a whole week 0.8 1.0 5.4 -0.7 0.1 -0.2 0.2 -0.3 -1.6 -0.8 -0.2 -0.9 -2.3
Unable to work because of sickness or disability 0.6 0.7 4.8 0.1 0.0 -0.4 -0.7 2.2 -0.2 -0.1 -0.4 -0.1 1.2
Commuting to job workplace: Cycle 0.4 0.4 1.7 0.3 0.1 -1.3 1.1 -0.7 0.2 0.7 -0.4 0.2 -0.1
Myopia 2.8 4.1 9.4 -1.5 -3.1 2.3 -1.3 0.7 0.4 -2.1 -2.7 -1.3 2.9
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.4 -1.6 -1.2 -0.4 0.5 -0.9 -1.5 -0.7 -1.4 -1.1 -0.2
Cholesterol lowering medication 0.6 0.9 5.8 -0.2 0.1 -0.4 -1.1 2.4 -0.1 -0.6 -0.9 0.1 0.8
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 2.7 1.1 1.5 -0.3 -0.6 0.1 0.4 0.7 1.7 0.5 -0.2
Pain experienced in last month 0.8 1.3 3.4 -1.2 -1.8 0.9 1.1 -0.0 0.9 -0.9 -1.8 -1.0 0.2
Supplements: Calcium 2.3 2.6 4.4 -2.0 -1.8 0.9 -1.1 1.1 -1.4 -2.1 -1.8 -1.9 1.4
Basal cell carcinoma (self-reported) 7.0 8.3 17.2 3.2 4.1 -3.3 0.2 -0.9 2.1 3.6 2.8 4.1 -1.3
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.6 0.1 0.4 0.1 0.4 1.3 0.2 -0.4 -0.1 0.0 0.7
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 2.9 -0.9 -1.0 0.5 0.0 1.5 -0.5 -0.7 -1.1 -1.2 1.7
Heart disease (siblings) 0.9 1.2 2.6 1.4 1.4 -0.7 0.4 0.6 0.8 1.4 1.0 1.6 0.6
Alcohol drinker status: Previous 0.6 0.7 2.7 0.4 0.3 0.2 -1.5 1.1 -0.0 0.4 0.5 0.4 -1.6
Pack years of smoking 0.2 0.3 0.7 0.6 0.2 0.2 -0.6 -0.1 0.3 0.8 0.6 0.6 -0.7
Impedance of whole body 3.3 16.9 33.2 -5.5 -4.4 3.1 -0.8 -1.9 -5.8 -5.6 -4.1 -4.9 -0.2
Leg fat mass (left) 0.5 2.0 4.0 1.6 1.5 -1.2 -0.3 -1.4 1.8 2.0 0.9 2.0 -0.6
Arm predicted mass (left) 1.1 5.6 11.0 2.6 3.0 -3.1 -0.5 0.7 1.9 3.3 2.2 2.8 -1.7