Hub : Genes

PRSS23

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1360	0.0300	2.8e-10	0.127	0.089	0.131	0.108	0.134	3.4e-15	5.5e-11	1.0e-15	5.0e-13	4.7e-16
2	GTEx	Adipose Visceral Omentum	0.1700	0.0570	1.5e-03	0.023	NA	0.034	NA	0.046	2.1e-02	NA	7.0e-03	NA	2.1e-03
3	GTEx	Artery Aorta	0.2330	0.0650	7.2e-05	0.145	NA	0.102	NA	0.128	2.3e-08	NA	3.1e-06	NA	1.5e-07
4	GTEx	Breast Mammary Tissue (Female)	0.0821	0.0746	1.8e-01	0.004	NA	-0.007	NA	-0.001	2.3e-01	NA	6.0e-01	NA	3.4e-01
5	GTEx	Cells Transformed fibroblasts	0.1280	0.0440	1.6e-03	-0.003	NA	0.008	NA	-0.002	7.8e-01	NA	7.3e-02	NA	5.2e-01
6	GTEx	Pancreas	0.2020	0.0820	6.8e-03	0.023	NA	-0.005	NA	-0.002	3.8e-02	NA	6.2e-01	NA	4.1e-01
7	GTEx	Thyroid	0.1780	0.0390	5.0e-08	0.086	NA	0.126	NA	0.137	4.3e-07	NA	7.2e-10	NA	1.2e-10
8	METSIM	Adipose	0.0711	0.0216	6.7e-06	0.058	0.047	0.042	0.048	0.050	4.1e-09	1.4e-07	5.1e-07	8.9e-08	4.7e-08
9	ROSMAP	Brain Pre-frontal Cortex	0.1713	0.0360	4.3e-12	0.131	0.128	0.142	0.161	0.141	1.7e-16	3.4e-16	7.5e-18	3.8e-20	1.0e-17
10	YFS	Blood	0.0196	0.0088	6.6e-03	0.009	0.002	0.006	0.006	0.010	5.8e-04	4.3e-02	3.4e-03	3.4e-03	2.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.8	2.9	5.6	1.9	2.4	-1.4	1.5	1.5	1.4	1.9	1.8	2.1	-0.0
Bipolar Disorder or Schizophrenia	0.4	0.9	2.7	0.7	1.7	-0.8	1.1	-0.0	0.5	1.0	0.8	1.3	0.1
Depressed Affect (Nagel 2018)	2.6	5.4	10.4	2.8	3.0	-1.5	0.7	-0.5	2.6	3.2	2.9	2.8	-0.9
Depression (Nagel 2018)	1.1	1.7	3.7	1.6	1.5	-0.3	0.5	1.0	1.3	1.6	1.9	1.6	0.3
Intelligence (Savage-Jansen 2018)	0.8	2.5	6.5	-2.0	-1.8	0.0	0.1	-0.6	-1.9	-1.6	-1.9	-2.6	-1.1
Neuroticism (Nagel 2018)	4.0	9.4	17.4	4.2	3.7	-1.3	1.5	1.8	3.3	4.0	4.0	3.5	-0.7
Schizophrenia (2018)	0.1	0.3	1.6	-0.7	0.2	0.1	0.3	-1.3	-0.5	-0.3	-0.5	-0.0	0.1
Schizophrenia vs Biploar Disorder	2.0	2.6	9.0	-1.3	-1.7	3.0	1.0	-1.1	-2.0	-1.9	-0.5	-1.4	-0.5
Worry (Nagel 2018)	2.7	5.7	11.2	3.3	3.2	-1.6	0.4	1.5	1.9	2.6	3.2	3.0	0.8
Alzheimer’s Disease (in mother)	0.7	0.8	2.1	-1.2	-1.0	0.5	0.3	0.9	-0.8	-0.7	-1.1	-1.4	-0.3
Alzheimer’s Disease (in father)	0.3	0.3	1.7	0.2	-0.4	0.1	-0.0	-0.8	1.3	0.5	-0.4	-0.1	0.6
Alzheimer’s Disease (including proxy)	0.8	1.2	2.8	-1.2	-1.7	1.2	-0.3	-0.1	-0.2	-0.9	-1.6	-1.6	0.7
Crohns Disease (2017)	0.3	0.6	2.5	-0.4	-0.7	0.1	-0.4	-1.6	-1.5	-0.3	-0.4	-0.1	-0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.7	-0.4	-1.0	0.8	0.2	-1.0	-0.7	-0.9	-0.7	-0.4	1.3
Ulcerative Colitis (UC)	0.5	0.9	5.2	-0.3	-0.8	0.9	0.4	-0.5	-0.2	-1.1	-0.5	-0.3	2.3
Major Depression (MDD)	0.3	0.4	1.9	-0.3	-0.0	0.2	0.2	0.7	-0.9	-1.4	-0.1	-0.4	-0.3
Reaction Time	0.6	1.1	3.8	0.8	0.4	1.3	-1.3	1.9	0.3	0.5	1.4	1.1	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.4	0.9	-0.5	-0.9	0.7	-0.4	-0.0	-0.6	-0.5	-0.7	-0.8	-0.1
Breast Cancer	0.6	1.5	4.0	0.5	1.0	-2.0	-1.8	1.6	-0.0	1.0	-0.3	-0.1	-1.8
Ovarian Cancer	0.3	0.4	1.1	-0.2	0.7	-0.8	1.1	0.2	-0.4	0.1	-0.6	-0.7	-0.4
Prostate Cancer	0.3	0.4	3.0	-0.2	0.5	-0.4	-1.7	-0.3	-0.5	0.0	0.2	-0.1	-0.6
Age at First Birth	3.6	5.3	11.7	-2.4	-3.4	2.1	-0.8	1.7	-1.1	-2.6	-2.6	-3.1	1.7
Bipolar Disorder (2011)	1.1	1.1	2.9	0.9	1.0	-1.6	0.8	-0.0	-0.1	1.2	0.9	1.7	-0.7
Body Mass Index (BMI) (2010)	0.9	1.2	3.0	1.7	1.4	-0.3	0.4	0.5	1.2	1.1	1.1	1.5	0.5
Coronary Artery Disease (CAD)	0.9	1.1	2.3	1.4	1.1	-0.5	0.1	0.5	1.1	1.5	1.4	1.3	-0.2
Crohns Disease (2012)	0.2	0.4	1.2	0.4	0.0	-0.4	-1.0	-1.1	-0.7	0.4	0.1	0.3	-0.7
Mean Putamen Volume	0.8	0.9	1.9	1.0	1.4	-1.0	-0.1	-0.6	-0.8	1.1	1.0	1.3	0.4
Fasting Glucose	1.4	1.7	4.9	2.2	1.0	0.7	-0.0	-0.3	0.4	1.2	2.0	2.1	0.4
HbA1C	0.3	0.4	0.8	0.5	0.6	-0.3	0.8	-0.2	0.4	0.4	0.9	0.6	-0.9
HDL Cholesterol	0.4	0.7	3.6	0.0	-0.6	1.9	1.6	0.4	0.5	-0.4	-0.1	-0.0	-0.0
LDL Cholesterol	1.5	2.4	5.0	2.2	1.4	-1.9	0.5	-0.5	1.1	2.2	0.9	2.0	1.5
Lupus	1.3	2.0	4.0	1.7	2.0	-0.0	0.6	0.1	1.6	1.6	1.7	1.3	-1.8
Neuroticism (2016)	0.7	1.0	2.3	1.5	0.8	-0.1	0.5	0.7	1.4	1.5	1.2	0.5	-0.3
Primary Biliary Cirrhosis	1.3	1.9	7.9	-0.9	-1.5	1.1	0.5	0.6	0.1	-1.3	-1.7	-1.3	2.8
Rheumatoid Arthritis	1.5	2.0	3.6	1.9	1.7	-1.1	1.3	0.3	1.6	1.3	1.7	1.6	1.2
Schizophrenia (2014)	0.1	0.3	1.1	-0.3	0.6	0.1	0.5	-1.1	-0.7	-0.0	-0.1	0.7	0.1
Triglycerides	0.9	1.5	4.5	1.1	1.8	-2.1	-1.1	0.8	0.6	1.6	0.8	0.7	-0.7
Type 2 Diabetes (T2D) (2012)	0.4	0.4	1.9	-0.3	0.1	-0.5	0.7	1.4	-0.3	-0.4	-0.8	-0.7	0.6
Ulcerative Colitis	0.4	0.6	1.8	-0.8	-0.4	0.2	-0.1	-0.8	-0.6	-1.2	-1.0	-0.3	1.3
Blood Eosinophil Count	0.2	1.2	2.6	-0.6	-1.0	1.6	-1.4	-0.8	-0.8	-1.6	-0.4	-0.3	1.2
Blood Platelet Count	0.3	3.6	13.1	-0.5	-2.5	3.6	-0.3	1.5	1.2	-2.1	-1.1	-0.9	2.5
Blood Red Count	0.6	5.7	34.6	-0.8	-2.4	5.9	1.4	-0.1	1.1	-2.9	-0.9	-0.9	1.6
Blood White Count	1.0	7.2	25.6	-2.1	-3.1	5.1	0.9	-2.3	-1.1	-3.7	-1.9	-1.7	2.2
Heel T-Score	1.1	8.9	16.6	3.6	3.9	-0.2	2.2	3.7	2.7	3.4	4.1	2.4	-0.9
BMI	0.9	5.0	9.7	2.8	2.3	-1.4	-0.3	-1.9	2.4	3.0	2.3	3.1	1.0
Height	0.2	3.8	8.8	-2.0	-0.4	-1.4	-3.0	0.9	-2.9	-1.2	-1.5	-2.1	-2.4
Waist Hip Ratio (WHR)	0.9	3.9	19.8	-0.9	-2.2	4.5	1.0	-1.9	0.6	-2.3	-0.7	-1.0	1.4
Systolic Blood Pressure	0.2	0.9	2.0	1.2	1.3	-0.4	-1.1	0.0	1.4	0.7	0.7	1.4	-0.0
Smoking Status	1.3	3.1	6.8	1.5	2.6	-0.5	0.6	-2.4	-0.4	1.2	2.4	1.8	-2.0
Allergy or Eczema	0.5	1.2	3.0	0.1	1.5	-1.4	-0.8	-1.7	-1.5	0.1	1.2	-0.4	-0.7
Cardiovascular Disease	0.5	1.5	3.7	1.5	1.9	-0.8	0.6	0.6	0.9	1.0	1.7	1.4	-1.1
Hypothyroidism (self reported)	0.1	0.3	0.7	-0.4	-0.6	-0.6	-0.5	0.6	0.3	0.2	-0.7	-0.8	0.8
Respiratory disease	0.6	1.4	3.2	1.4	1.8	-1.6	1.0	-0.7	0.9	1.3	1.2	0.8	0.2
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.0	1.3	1.6	0.0	-1.1	-1.5	1.4	1.2	1.5	1.4	2.0
Lung FEV1/FVC ratio	0.3	1.5	5.7	-1.0	-1.8	2.4	-0.1	0.2	-0.1	-1.2	-0.9	0.1	1.7
Lung FVC	0.1	0.5	1.7	-0.0	-0.4	-0.1	0.9	0.7	1.3	-0.2	-0.8	-0.3	1.0
Neuroticism	2.8	6.9	13.0	3.6	3.4	-1.1	-0.2	1.7	2.7	3.1	3.6	3.2	-0.3
Chronotype (morning person)	1.2	2.8	6.7	1.9	1.2	0.1	1.9	-1.2	2.6	2.4	1.8	1.4	-0.7
Hair Pigment	0.0	1.0	2.9	1.2	0.3	-0.0	0.2	1.0	1.7	0.8	0.7	1.7	0.9
Tanning	0.1	0.9	2.4	1.2	0.1	0.8	-1.0	-1.2	0.5	1.2	1.6	0.4	-0.7
Hand grip strength (left)	0.3	0.8	3.1	0.3	0.0	-1.1	1.8	-0.9	1.2	0.6	-0.9	0.5	-0.6
Number of treatments/medications taken	0.6	1.0	5.5	0.7	1.1	-1.2	-0.6	2.3	0.2	0.3	0.2	0.8	0.4
Average weekly spirits intake	0.7	0.9	2.8	0.6	1.7	-1.6	-0.0	0.1	-0.8	0.5	0.8	1.2	-0.5
Sensitivity / hurt feelings	4.2	7.1	15.3	3.9	3.0	-0.7	0.4	2.1	2.8	3.5	3.5	3.1	0.0
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.2	0.3	0.3	-0.2	-1.1	0.5	-0.2	0.1	0.7	0.3	0.8
Hearing difficulty/problems: Yes	0.2	0.4	0.9	-0.9	-0.3	0.2	0.4	-0.4	-0.8	-0.5	-0.9	-0.8	-0.2
Relative age of first facial hair	0.9	1.8	4.0	0.9	1.7	-2.0	1.2	0.6	-0.1	1.5	1.1	1.1	-1.8
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.5	-0.5	-1.1	2.1	-0.1	-0.7	-0.9	-1.5	-0.6	-1.1	0.7
Ever used hormone-replacement therapy (HRT)	1.7	2.2	5.1	1.9	2.3	-0.6	-0.3	1.0	1.0	1.7	1.9	1.8	-0.9
Ever had hysterectomy (womb removed)	0.4	0.5	2.6	0.2	0.1	-0.2	-0.6	0.9	0.1	-0.4	-0.2	0.8	1.6
Systolic blood pressure, automated reading	0.5	1.5	3.0	1.5	1.7	-1.1	-0.6	0.7	1.7	1.4	0.5	1.5	0.0
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	7.7	1.3	0.9	1.0	-2.8	-0.8	0.7	0.8	1.6	0.8	-0.8
Angina	0.7	1.0	3.2	0.9	1.8	-0.9	0.6	1.1	0.6	0.8	0.6	1.1	0.9
Medication for hormone replacement therapy	3.8	4.2	8.7	2.7	2.6	0.9	0.6	0.8	3.0	2.4	2.5	2.0	-1.3
Vitamin and mineral supplements	1.6	2.2	7.8	-0.7	0.2	-0.1	2.5	-2.8	-1.1	-0.2	-0.0	-0.9	-2.4
Supplements: Zinc	1.9	2.1	4.4	-1.4	-2.0	1.1	0.8	0.1	-0.2	-2.1	-1.6	-1.5	2.1
Medication: Co-codamol	0.3	0.3	1.1	0.2	0.8	-0.8	0.4	-0.6	0.1	1.1	0.5	-0.2	-0.4
Medication: Metformin	0.9	1.3	2.2	1.3	1.5	-0.3	-0.2	-1.4	1.3	1.0	1.4	1.4	0.4
Diabetes (father)	1.0	1.2	2.6	1.2	1.0	-1.6	-0.6	-0.2	1.3	1.6	0.7	1.4	-0.2
Diabetes (mother)	0.9	1.2	5.1	-0.0	-0.2	1.0	0.7	1.6	0.4	-1.0	-0.4	-0.9	2.3
Severe depression (siblings)	0.5	0.6	2.8	0.5	0.7	0.1	0.1	1.3	-0.3	0.1	0.6	0.2	-1.7
Pack years adult smoking proportion	0.3	0.5	1.5	0.7	0.6	-0.3	-0.3	-0.5	0.2	1.0	0.8	0.8	-1.2
Impedance of leg (right)	1.9	9.3	24.3	-4.0	-2.5	2.2	-0.7	-1.2	-4.9	-4.1	-2.4	-3.8	-1.3
Leg fat-free mass (left)	0.8	4.1	8.3	2.4	2.3	-2.3	-0.1	0.3	2.5	2.9	1.6	2.6	-0.4
Trunk fat percentage	0.2	0.9	6.8	-0.6	-0.4	0.5	-0.7	-2.6	-0.2	-0.2	-0.8	0.1	-0.0
Hand grip strength (right)	0.6	1.5	6.0	0.8	1.2	-2.5	1.0	-1.1	0.6	1.3	0.2	0.8	-1.5
Townsend deprivation index at recruitment	1.2	1.7	9.2	-1.6	-0.1	-1.4	-0.9	0.0	-3.0	-1.0	-0.2	-0.5	-1.2
Current tobacco smoking	0.5	0.8	3.3	-0.6	0.1	-0.8	0.1	-0.9	-1.7	-0.1	-0.0	-0.5	-1.8
Average weekly fortified wine intake	1.6	1.9	5.1	-1.3	-1.3	-0.9	-2.1	-0.1	-0.0	-1.0	-2.2	-1.6	1.2
Maternal smoking around birth	0.4	0.6	3.3	0.5	0.9	0.4	-0.5	-1.8	0.1	0.0	0.5	0.5	-0.7
Fed-up feelings	1.1	2.0	4.2	1.4	2.0	-1.3	0.7	-1.6	1.0	1.6	1.9	1.5	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.4	0.9	1.8	-1.0	-0.6	-0.1	-0.0	1.2	1.8	1.2	-0.3
Relative age voice broke	0.4	0.6	3.0	-0.1	0.8	-1.7	1.2	-0.2	-0.1	0.4	-0.0	0.6	-0.4
Taking other prescription medications	0.8	1.3	3.0	-1.3	-0.0	-0.6	0.8	1.2	-1.7	-1.5	-1.3	-1.3	0.3
Age when periods started (menarche)	0.7	1.7	6.2	1.0	1.5	0.4	1.7	-0.3	-0.5	1.1	1.6	0.6	-2.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.2	0.6	0.8	-0.6	1.1	0.1	0.9	0.5	0.2	1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	6.0	1.9	1.3	1.1	1.0	1.6	1.9	1.4	2.5	1.1	0.3
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	8.3	2.2	1.8	0.6	-1.9	-0.9	-0.0	1.6	2.9	2.1	-1.2
Qualifications: CSEs or equivalent	0.3	0.4	2.1	0.2	0.5	0.4	1.0	1.5	0.4	0.5	0.6	-0.1	-0.1
Serious illness, injury or assault to yourself	0.4	0.5	1.2	0.8	0.6	0.3	1.0	0.3	1.1	0.6	1.0	0.4	-0.1
High blood pressure	0.3	0.9	2.2	1.5	1.0	0.3	-0.2	0.6	1.4	0.6	1.3	1.1	0.3
Hayfever, allergic rhinitis or eczema	0.4	1.0	3.9	-0.2	1.1	-0.5	0.1	-1.1	-2.0	-0.7	1.0	-0.8	-1.0
Multivitamins +/- minerals	1.5	1.9	8.0	0.3	-0.5	0.9	-2.1	2.8	1.0	-0.1	-0.1	0.1	2.1
Stomach or abdominal pain in last month	2.4	3.0	7.2	1.7	2.2	-2.4	0.2	-0.7	0.8	2.7	1.8	1.4	-1.4
Supplements: Glucosamine	2.8	3.6	7.6	2.5	2.2	-1.5	0.2	1.4	1.6	2.8	2.2	2.4	-0.7
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	4.1	-0.2	-0.4	1.4	2.0	-1.6	0.5	-0.2	-0.1	-0.0	-0.0
Medication: Atenolol	2.9	3.7	6.7	2.2	2.4	-1.6	2.1	-0.8	0.8	2.6	1.9	1.8	-1.9
Medication: Levothyroxine sodium	0.4	0.6	2.1	-0.8	-0.6	-0.6	1.5	0.3	-0.0	-0.1	-1.3	-0.8	0.6
Sitting height	0.3	2.2	9.2	-1.4	0.4	-3.0	-1.9	0.1	-1.6	-0.8	-1.1	-1.2	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.6	-0.4	-0.2	-0.1	-1.3	-0.3	-1.3	-0.3	-0.5	-1.1	-0.8
High blood pressure (mother)	0.0	0.1	0.3	-0.0	0.2	0.1	0.3	0.4	0.5	-0.1	-0.0	-0.0	0.2
Body mass index (BMI)	1.1	4.7	10.9	3.0	1.9	-1.0	0.4	-0.7	3.3	3.1	1.8	2.9	0.3
Impedance of leg (left)	2.3	11.0	29.3	-4.6	-2.9	1.6	-1.1	-1.7	-5.4	-4.3	-3.0	-4.0	-1.5
Leg predicted mass (left)	0.7	3.8	7.7	2.3	2.2	-2.3	-0.0	0.4	2.5	2.8	1.5	2.5	-0.4
Trunk fat mass	0.1	0.6	3.5	0.3	0.5	-0.5	-0.7	-1.9	0.5	0.8	-0.1	0.9	-0.2
Waist circumference	0.3	1.0	2.7	1.1	0.5	0.6	-0.3	-1.3	1.6	0.8	0.6	1.5	0.6
Number of incorrect matches in round	0.2	0.3	1.6	0.2	0.1	0.6	-0.4	-0.1	0.1	-0.2	0.0	0.8	1.3
Past tobacco smoking	1.5	2.8	11.8	-1.4	-2.2	-0.2	0.6	3.4	0.4	-1.1	-2.2	-1.2	1.4
Alcohol usually taken with meals	0.2	0.4	1.2	-0.5	-0.7	-0.6	-0.2	-0.5	0.9	0.2	-1.1	-0.1	0.5
Nervous feelings	2.4	4.5	9.8	3.1	3.0	-0.9	-0.7	1.0	1.6	2.2	3.0	2.5	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	2.1	0.6	0.7	-0.3	-0.2	0.8	-0.3	0.0	0.8	0.3	1.4
Hearing difficulty/problems with background noise	2.1	3.3	7.7	-2.5	-1.6	0.3	-0.7	-1.9	-2.3	-2.1	-1.7	-2.8	-0.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.3	-0.7	0.5	0.1	0.2	-0.8	-0.6	0.1	-0.7	-0.2
Had menopause	0.7	0.9	2.1	0.6	1.2	-1.0	-1.5	0.3	-0.3	1.1	0.5	0.6	-1.4
Had other major operations	0.8	1.0	6.5	-0.5	-0.2	0.1	0.0	2.5	0.3	-0.2	-0.9	-0.9	1.1
Forced vital capacity (FVC)	0.3	1.2	2.8	-1.7	-0.7	-1.3	0.7	-0.2	-1.5	-1.2	-1.4	-1.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	8.2	2.6	1.0	2.0	1.4	1.3	2.5	1.4	2.9	1.6	1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	0.7	0.6	0.2	-0.4	0.4	1.1	0.8	0.7	0.3	-0.3
Qualifications: None of the above	1.5	3.2	7.7	2.5	2.2	-0.5	0.2	-0.3	1.8	2.2	2.8	2.1	-0.7
Financial difficulties in last 2 years	0.7	0.9	4.0	-0.8	-0.3	-0.8	-0.7	-2.0	-1.4	-0.4	0.2	-0.5	-0.9
Mouth/teeth dental problems	2.0	3.1	6.8	-1.8	-2.6	2.2	-0.8	0.1	-0.9	-2.5	-2.1	-1.4	1.1
Heart attack	0.2	0.2	1.3	-0.1	0.4	-0.1	0.5	1.1	0.3	-0.4	-0.3	-0.0	0.6
Allergy	0.5	1.0	3.1	-0.4	-1.7	0.7	0.0	0.5	1.8	-0.4	-1.2	0.4	1.4
Pain all over the body in last month	0.4	0.4	1.7	-0.2	-0.6	0.7	-0.7	1.3	-0.7	-0.5	-0.4	-0.2	0.6
Diabetes (self-reported)	0.8	1.3	3.2	1.1	1.0	0.5	-1.6	-0.9	1.2	0.5	1.0	1.2	1.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.3	-0.0	-0.0	0.5	0.6	-0.9	-0.7	-0.2	-0.0	0.5
Medication: Ramipril	0.6	0.7	4.4	0.1	0.5	0.1	-0.7	-1.4	0.1	0.4	0.2	-0.2	-2.1
Medication: Simvastatin	0.4	0.6	1.6	1.0	0.9	-0.2	-1.3	0.2	0.6	0.9	0.5	1.2	-0.1
Fluid intelligence score	0.8	1.7	3.2	-1.7	-1.4	0.4	0.9	0.1	-1.7	-1.4	-1.8	-1.7	-0.8
Illnesses of siblings	2.1	2.9	6.2	-2.5	-1.7	0.9	0.4	-0.1	-2.4	-2.2	-1.8	-2.4	0.2
Neuroticism score	2.4	5.0	11.7	3.0	3.4	-1.0	-0.0	0.6	1.7	2.5	3.4	2.7	-0.4
Weight	0.6	2.9	6.4	2.0	2.0	-1.8	-0.4	-0.5	1.8	2.5	1.3	2.3	-0.9
Impedance of arm (right)	3.3	15.6	32.2	-5.2	-4.5	3.8	-1.1	-1.1	-4.9	-5.7	-3.9	-4.6	0.4
Arm fat percentage (right)	0.2	0.8	2.7	0.6	-0.1	1.0	-0.4	-1.6	1.6	0.4	0.0	1.0	0.7
Trunk fat-free mass	1.1	6.1	10.4	2.9	3.2	-3.2	-0.3	1.4	2.0	3.2	2.4	2.9	-1.3
Hip circumference	0.6	2.8	5.6	1.6	2.1	-2.2	-0.5	-0.6	1.1	2.4	1.3	2.4	-0.9
Time employed in main current job	1.0	1.2	5.5	1.3	0.3	0.8	-0.3	1.3	1.1	0.4	1.0	0.4	2.4
Alcohol intake versus 10 years previously	0.4	0.6	1.8	0.5	1.1	-1.3	0.4	1.3	-0.5	0.4	0.6	-0.5	0.3
Father’s age at death	1.7	2.2	3.9	-1.7	-1.8	0.9	0.9	-0.9	-1.8	-2.0	-1.7	-1.9	0.6
Worrier / anxious feelings	2.1	3.9	7.7	2.8	2.6	-1.2	1.3	1.4	1.3	2.2	2.6	2.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.4	0.2	0.2	-0.3	-1.0	0.3	-0.1	-0.3	-0.1	-0.1	1.2
Falls in the last year	0.2	0.3	1.1	-0.2	-1.0	0.8	0.5	0.2	-0.3	-0.2	-0.6	-0.5	0.5
Hair/balding pattern: Pattern 3	0.6	0.9	3.0	-0.9	-0.6	-1.7	0.5	-1.0	-0.6	-0.3	-1.6	-0.6	0.6
Number of live births	0.5	0.8	1.6	-1.3	-1.2	0.7	-0.4	-1.0	-0.5	-1.1	-0.7	-1.1	-0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.4	-1.9	-1.2	-0.7	0.9	-0.2	-1.1	-1.2	-1.6	-1.1	0.6
Pulse rate	0.5	0.8	2.7	-0.8	-0.6	0.8	-0.9	0.1	-1.6	-1.3	-0.5	-0.9	0.2
Happiness	0.5	0.7	2.1	-0.9	0.1	-1.4	1.2	0.1	-0.6	-0.4	-1.2	-0.4	-0.4
Noisy workplace	1.4	1.8	5.0	1.1	2.2	-1.4	1.7	-0.0	0.5	1.3	1.2	1.3	-1.2
Qualifications: A levels/AS levels or equivalent	3.1	6.8	12.5	-2.9	-3.5	2.9	0.6	-2.4	-1.4	-3.5	-3.0	-2.6	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.7	0.0	0.7	0.3	-0.5	0.4	0.5	0.6	0.2	-0.1
Mouth/teeth dental problems: Dentures	4.4	7.5	17.3	3.4	3.5	-2.0	1.8	-0.2	3.2	4.2	2.9	2.7	-0.6
Asthma	0.3	0.6	2.5	0.7	1.2	-0.3	0.7	-0.5	-0.4	0.6	0.7	0.4	-1.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.8	-0.1	0.7	-1.7	1.4	1.2	-0.6	0.0	-0.2	-0.1	-0.1
Medication: Cholesterol lowering	2.4	3.7	8.4	2.9	2.5	-0.8	-0.7	0.6	1.7	2.6	2.6	2.2	-0.3
Depression (self-reported)	0.7	0.8	2.7	-0.8	-0.5	0.4	0.2	1.2	-0.0	-1.6	-1.0	-0.8	1.2
Medication: Lansoprazole	1.7	2.0	4.1	-2.0	-0.8	0.6	-0.1	0.6	-1.9	-1.9	-1.9	-1.8	0.3
Prospective memory result	2.4	3.0	7.7	2.3	2.0	0.1	-0.4	-0.5	1.4	1.9	2.8	2.5	-0.8
Lung cancer (father)	1.4	1.6	4.8	1.2	2.2	-0.9	-1.6	1.2	-0.2	1.0	1.4	1.0	-1.0
Illnesses of mother	0.7	0.9	1.6	-1.1	-1.2	-0.1	-1.0	-0.9	-0.9	-1.0	-1.3	-0.8	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	-0.9	-0.6	-0.9	1.2	-0.3	-0.4	-0.7	-0.8	-0.1	1.3
Pulse wave Arterial Stiffness index	4.5	5.3	13.0	2.9	3.0	-1.6	-0.3	0.5	1.8	3.6	2.6	2.4	-1.8
Impedance of arm (left)	4.0	18.4	36.2	-5.6	-5.0	4.1	-0.6	-1.9	-5.1	-6.0	-4.4	-5.0	0.8
Arm fat mass (right)	0.3	1.2	4.0	1.4	0.8	-0.1	-0.1	-0.9	2.0	1.3	0.6	1.6	0.1
Trunk predicted mass	1.0	5.6	9.7	2.8	3.0	-3.1	-0.2	1.5	2.0	3.1	2.3	2.7	-1.1
Standing height	0.3	2.8	10.4	-1.7	0.3	-1.8	-1.5	0.5	-3.2	-1.0	-0.9	-1.0	-2.4
Length of working week for main job	1.4	1.6	4.3	1.1	1.4	-0.7	2.1	0.0	-0.0	1.3	1.9	0.6	-1.3
Exposure to tobacco smoke at home	0.4	0.5	3.7	-0.2	-0.6	1.9	-0.2	-0.3	-0.2	-0.7	-0.0	-0.4	0.1
Breastfed as a baby	0.2	0.2	1.5	-0.3	-0.1	-0.2	-1.2	-0.3	-0.2	-0.3	-0.3	0.3	-0.4
Tense / ‘highly strung’	0.9	1.6	3.9	1.8	2.0	-0.6	-0.8	1.0	0.6	0.9	1.6	1.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	3.0	-0.8	-0.1	0.1	-1.1	-0.2	-1.7	-1.3	-0.1	-0.6	-0.8
Hair/balding pattern: Pattern 4	0.5	1.1	6.6	-0.7	0.5	-2.6	1.4	-0.7	-0.8	0.5	-0.2	-0.6	-0.3
Birth weight of first child	0.6	1.1	2.9	-1.5	-1.3	-0.1	-0.1	0.2	-1.7	-1.2	-1.4	-0.6	0.6
Peak expiratory flow (PEF)	2.7	6.3	14.6	-3.2	-3.8	2.1	0.9	-0.7	-1.8	-2.9	-3.2	-3.2	0.7
Pulse wave reflection index	2.6	3.2	6.9	1.7	2.3	-1.7	1.3	-0.4	1.2	2.6	1.9	1.5	-2.3
Ever highly irritable/argumentative for 2 days	3.6	4.4	9.2	3.0	2.1	-0.7	0.7	-1.4	1.8	2.7	2.8	2.9	-1.0
Loud music exposure frequency	1.0	1.1	4.3	-0.8	-0.4	1.6	2.1	-0.9	-0.4	-1.2	0.0	-1.0	0.6
Qualifications: O levels/GCSEs or equivalent	4.9	7.8	13.9	-3.7	-3.2	1.3	-0.3	-1.5	-3.1	-3.6	-3.7	-3.7	-0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.2	-0.3	-0.1	-0.0	-1.0	-1.2	-0.6	-0.3	0.1	0.2	-1.5
Blood clot in the leg (DVT)	0.6	0.7	2.1	-0.6	-0.9	0.3	0.4	1.4	-0.2	-0.3	-1.0	-0.9	1.4
Medication: Paracetamol	0.7	1.2	7.3	-0.6	0.4	-1.0	1.3	0.2	-2.7	-1.0	0.1	-0.5	-0.4
Headache pain in last month	0.2	0.4	1.3	0.8	0.9	-0.2	0.1	0.7	-0.0	0.3	1.2	0.6	0.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	5.3	-2.3	-1.9	0.5	1.0	-0.1	-1.5	-1.9	-1.9	-1.8	-0.0
Glaucoma (self-reported)	3.5	4.1	7.4	-2.1	-2.6	2.2	-0.5	-0.8	-2.0	-2.7	-1.9	-2.7	1.4
Gout (self-reported)	0.2	0.3	1.3	0.7	-0.3	0.6	1.1	0.7	-0.1	0.2	0.2	0.5	-0.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.2	-0.7	-0.7	-0.8	-0.2	1.0	0.1	-0.0	-1.1	-1.0	1.0
Medication: Amlodipine	0.2	0.3	1.4	0.3	0.6	-0.8	0.1	0.7	-0.3	0.0	-0.2	0.3	-1.2
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.3	0.1	0.6	-0.6	1.1	-0.3	-0.7	0.8	0.2	-0.1	-1.1
Birth weight	0.1	0.3	1.0	-0.7	0.3	-0.6	-1.0	0.3	-0.6	-0.3	-0.5	-0.2	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.5	0.5	-0.8	0.2	-0.7	-0.2	0.6	0.6	0.8	-0.8
High blood pressure (siblings)	1.0	1.5	4.0	1.9	1.1	0.1	-0.7	0.3	2.0	1.2	1.4	1.4	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	1.8	-1.4	-0.7	-1.2	0.9	-0.4	-1.1	-1.3	-1.2	-0.7	1.0
Body fat percentage	0.2	0.7	5.3	0.0	-0.1	0.5	-0.6	-2.3	0.5	0.2	-0.4	0.5	-0.0
Leg fat percentage (right)	0.4	1.3	2.5	1.5	1.1	0.1	-0.3	-1.5	1.5	1.3	0.9	1.6	-0.1
Arm fat-free mass (right)	1.0	5.0	10.7	2.4	2.9	-3.3	0.2	0.3	1.7	3.1	1.9	2.5	-1.6
Exposure to tobacco smoke outside home	0.3	0.4	2.3	0.0	0.4	-0.4	0.6	-1.5	0.0	0.1	0.4	0.6	0.1
Comparative body size at age 10	0.7	2.0	10.1	0.5	-1.4	1.8	-3.2	-0.2	1.6	0.1	-0.4	1.0	1.0
Number of full brothers	0.6	0.7	2.0	-0.8	-1.3	1.4	0.5	-0.3	-0.7	-0.9	-0.4	-0.5	-1.1
Worry too long after embarrassment	0.2	0.3	1.6	0.1	-0.0	-0.3	-1.3	0.5	-0.8	-0.3	0.3	-0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.6	-1.0	-1.0	1.1	-1.3	0.2	-1.5	-1.6	-0.8	-0.7	0.2
Wheeze or whistling in the chest in last year	0.5	0.9	4.2	0.1	1.0	-1.1	0.4	2.0	-0.7	0.4	-0.1	-0.6	-1.2
Number of children fathered	2.3	2.6	5.5	1.8	1.6	1.2	1.8	-1.8	2.3	1.0	1.2	2.0	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	6.2	-0.6	-0.9	0.9	-2.5	0.9	-0.5	-1.2	-0.9	-0.5	1.0
Age at first live birth	0.5	0.8	1.7	-0.8	-1.2	0.8	-0.5	0.7	-0.2	-1.1	-1.3	-1.0	0.9
Pulse wave peak to peak time	3.9	4.6	11.6	-2.9	-2.7	1.1	0.3	-0.5	-2.1	-3.4	-2.4	-2.3	1.5
Health satisfaction	1.0	1.3	4.6	1.2	2.1	-0.8	0.7	0.6	-0.3	1.2	1.5	0.9	-0.7
Shortness of breath walking on level ground	1.1	1.3	3.5	1.1	1.9	-1.8	1.2	0.1	-0.1	0.7	1.1	1.2	-0.1
Qualifications: College or University degree	0.8	2.4	5.7	-1.7	-2.4	1.0	1.4	0.3	-0.8	-2.0	-2.1	-1.1	1.3
Eye problems/disorders: None of the above	0.6	0.7	1.9	0.3	1.0	-1.4	0.4	-0.4	0.8	0.8	0.1	0.7	-1.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.9	-0.2	0.1	-1.1	-2.0	-0.1	-0.6	-0.2	0.2	0.1	0.7
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.1	0.2	0.1	-0.3	0.1	-0.3	-0.4	0.3	-0.4	0.4
Medication for pain relief, constipation, heartburn	0.5	0.9	3.4	-0.7	-1.8	1.4	-1.1	-0.6	0.3	-0.2	-0.5	-0.9	0.7
Neck or shoulder pain in last month	0.3	0.4	1.2	0.8	1.0	-0.1	-0.7	-0.2	-0.2	0.6	1.1	0.7	0.2
Medication: Blood pressure	0.4	0.7	1.5	1.2	0.7	0.2	-1.2	-1.0	0.8	0.7	0.8	1.1	0.3
Angina (self-reported)	0.8	1.0	3.2	1.0	1.8	-0.8	0.7	1.3	0.6	0.7	0.6	1.1	0.8
Migraine (self-reported)	0.7	0.8	3.5	-0.6	0.1	-0.0	1.7	-0.4	-1.9	-0.6	-0.5	0.2	-0.8
Medication: Ibuprofen	0.5	0.6	2.7	0.2	0.6	-1.6	1.4	0.6	0.2	0.4	0.2	0.2	0.1
Medication: Allopurinol	0.7	1.0	3.2	-0.4	-1.3	1.8	1.5	0.0	0.1	-1.1	-1.1	-0.5	-0.0
Medication: Omeprazole	0.3	0.3	1.4	0.5	0.7	0.6	-0.6	-0.4	-0.1	0.1	1.2	-0.0	0.5
Medication: Seretide 50 evohaler	0.5	0.6	3.5	-0.4	-0.9	0.5	1.9	-0.0	-0.2	-0.6	-0.6	-0.4	0.6
Mean time to correctly identify matches	0.9	1.7	6.5	1.1	0.3	1.4	-1.8	2.6	0.8	0.4	1.2	0.8	1.0
Heart disease (mother)	1.1	1.3	4.3	0.4	1.4	-2.1	1.3	1.3	-0.5	0.5	0.5	0.0	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	-0.8	-0.8	-0.1	0.6	1.2	-1.4	-0.1	-1.0	-1.1	-0.6
Whole body fat mass	0.2	0.9	2.8	0.8	0.8	-0.5	-0.6	-1.7	1.0	1.0	0.3	1.2	-0.3
Leg fat mass (right)	0.5	2.0	3.8	1.8	1.6	-1.1	-0.2	-1.2	1.7	2.0	1.0	1.9	-0.6
Arm predicted mass (right)	1.1	5.4	12.6	2.5	3.0	-3.5	0.2	0.5	1.7	3.3	2.0	2.5	-1.4
Pulse rate, automated reading	1.6	5.1	9.3	-2.7	-2.9	1.8	-1.8	-0.0	-2.7	-3.0	-2.4	-2.6	-0.1
Alcohol intake frequency.	0.3	0.6	4.0	0.6	0.7	-0.5	-0.3	2.0	0.3	0.7	0.3	0.7	-0.0
Comparative height size at age 10	0.2	1.3	4.5	0.6	1.3	-1.2	-1.7	0.5	-0.3	0.9	1.0	0.4	-2.1
Number of full sisters	0.3	0.4	1.4	-0.4	-0.1	0.2	0.3	0.6	-1.2	-0.8	0.0	-0.2	-1.1
Suffer from ‘nerves’	0.6	1.0	3.2	1.0	1.4	-0.7	0.5	1.0	0.0	0.4	1.2	0.6	1.8
Overall health rating	0.3	0.6	1.8	1.0	1.3	-0.2	0.2	1.3	0.3	0.4	1.0	0.6	0.0
Chest pain or discomfort	0.6	0.8	4.1	0.3	1.2	-1.4	-0.1	2.0	0.1	0.3	-0.2	0.3	0.5
Had major operations	0.4	0.4	1.7	-0.7	-0.2	-0.4	0.4	-0.2	-1.3	-0.6	-0.5	-1.1	0.3
Age at last live birth	0.2	0.3	0.7	-0.4	-0.8	0.1	-0.0	0.7	0.3	-0.2	-0.5	-0.7	-0.6
Family relationship satisfaction	0.2	0.3	1.4	0.2	0.3	-0.4	0.1	-0.8	0.1	0.2	0.2	-0.2	-1.2
Leg pain on walking	2.6	3.2	6.9	2.3	2.0	-1.0	1.1	1.4	1.4	2.1	2.4	2.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.7	0.6	0.4	0.6	0.1	0.9	-0.2	0.1	0.2	-0.9	0.2
Commuting to job workplace: Car/motor vehicle	3.0	3.5	7.0	2.6	2.2	-0.6	-0.0	1.7	0.9	2.2	2.4	1.8	-2.2
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.6	-0.0	-1.1	1.9	-1.3	0.5	0.9	-0.8	-0.8	0.3	1.4
Medication: Aspirin	1.0	1.3	3.1	1.6	1.8	-0.3	-0.2	1.5	0.8	0.8	0.8	1.8	-0.4
Supplements: Vitamin C	0.5	0.5	3.7	0.2	-0.3	0.6	-0.8	1.9	0.6	0.2	0.3	0.0	0.3
Knee pain experienced in last month	0.5	0.7	5.4	0.4	0.4	0.2	-0.7	-2.3	-0.0	0.1	0.9	0.1	-0.4
Hypertension (Self-reported)	0.3	0.8	2.1	1.4	0.9	0.2	-0.2	0.6	1.4	0.5	1.2	1.1	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	3.1	-0.6	-0.6	1.8	1.0	-1.0	-0.3	-1.3	0.2	-0.5	1.3
Illnesses of father: Heart disease	0.7	1.0	3.6	0.7	-0.4	0.4	-1.5	-0.6	1.9	0.3	-0.2	0.8	1.4
Illnesses of siblings: Diabetes	0.5	0.6	2.1	0.1	-0.8	0.7	-1.0	-1.5	1.2	-0.4	-0.5	0.1	0.3
Smoking status: Previous	1.8	2.6	9.2	1.3	2.3	-0.5	-0.5	-3.0	0.1	1.4	1.8	1.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.7	-1.5	-0.4	-1.0	0.0	-1.9	-1.9	-0.8	-0.9	-0.6	-1.2
Whole body fat-free mass	1.0	5.5	10.4	2.7	2.9	-3.1	-0.2	0.8	2.2	3.2	2.1	2.8	-1.1
Leg fat-free mass (right)	0.7	3.7	7.5	2.1	2.1	-2.7	-0.0	0.1	2.3	2.7	1.3	2.5	-0.5
Arm fat percentage (left)	0.2	0.9	4.0	0.4	-0.3	1.2	0.1	-2.0	1.5	0.2	-0.2	0.7	0.8
Average weekly red wine intake	1.0	1.5	4.4	-1.3	-1.1	-0.1	-0.9	-2.1	-0.2	-1.5	-1.6	-1.4	0.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.6	1.4	0.9	-0.5	-0.2	-0.1	1.6	1.0	0.6	1.1	0.5
Mood swings	2.5	4.5	8.8	2.9	2.8	0.2	-0.1	-0.6	2.2	2.5	3.0	2.5	-1.4
Loneliness, isolation	0.9	1.2	3.4	1.1	1.8	-0.9	-0.1	0.4	0.8	1.4	1.5	1.3	0.5
Long-standing illness, disability or infirmity	0.3	0.4	1.3	-0.2	-0.0	0.2	-0.7	0.2	-0.3	-1.1	-0.8	-0.8	1.2
Ever had bowel cancer screening	0.5	0.6	1.5	1.2	0.7	0.1	0.9	0.5	-0.4	0.5	1.0	0.9	-0.7
Diabetes diagnosed by doctor	1.2	1.9	3.3	1.3	1.4	0.7	-1.7	-1.8	1.3	1.0	1.6	1.5	1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.6	0.4	0.4	-0.2	1.3	-1.2	0.6	0.7	0.6	-0.1	-0.3
Friendships satisfaction	0.8	0.9	1.6	1.1	0.9	-1.2	-0.8	0.2	1.1	1.3	0.8	0.8	-0.9
Qualifications: nursing, teaching	0.3	0.4	0.9	-0.6	-0.7	0.4	-0.3	-1.0	-0.7	-0.5	-0.9	-0.4	0.2
Commuting to job workplace: Walk	1.0	1.1	2.0	-1.4	-1.2	-0.4	-1.0	-1.3	-0.4	-0.9	-1.4	-0.9	1.0
Eye problems/disorders: Cataract	0.7	0.8	2.7	1.0	0.1	0.7	0.2	1.0	0.6	0.0	0.8	1.1	1.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.9	-1.5	-0.6	-0.4	-0.3	-0.4	-2.0	-0.7	-0.9	-1.5	-0.4
Medication for cholesterol	0.7	1.1	5.2	-1.0	-0.8	-1.2	0.7	-2.3	-0.9	0.1	-0.6	-0.8	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.2	5.1	1.5	0.9	-0.3	-1.8	-0.9	2.3	1.8	0.9	1.5	-1.7
Back pain experienced in last month	0.5	0.7	2.7	0.4	0.8	0.3	-1.6	-1.0	-0.8	-0.1	1.1	0.4	-0.3
Mineral and other dietary supplements	1.8	2.4	4.0	-2.0	-1.6	1.8	0.5	-1.2	-1.6	-1.9	-1.4	-2.0	-0.7
Breast cancer (self-reported)	2.1	2.5	8.3	-1.6	-1.1	-0.2	-1.6	2.9	-1.2	-1.5	-1.6	-1.4	1.2
Asthma (self-reported)	0.3	0.6	1.6	0.9	1.3	-0.1	0.5	-0.3	-0.1	0.6	0.8	0.4	-1.2
Osteoporosis (self-reported)	1.2	1.4	5.9	-0.6	0.1	-0.9	-0.6	2.0	-1.5	-0.3	-0.6	-0.7	-2.4
Osteoarthritis (self-reported)	0.7	0.9	2.2	0.4	1.0	-1.4	1.1	0.5	-0.5	1.1	0.4	-0.1	-1.5
Medication: Aspirin	1.6	2.0	5.1	2.1	2.1	-0.2	0.4	0.8	1.5	1.1	1.4	2.2	-0.3
Medication: Gliclazide	1.6	1.9	5.5	1.6	1.4	0.5	0.5	-0.1	2.0	0.4	1.4	1.4	2.3
Illnesses of father: None of the above (group 1)	0.3	0.4	1.5	-0.1	0.0	0.8	1.2	0.5	-0.3	-0.2	0.7	-0.7	0.6
Smoking status: Current	0.4	0.7	2.7	-0.3	0.5	-0.6	0.0	-0.6	-1.6	0.1	0.3	-0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.0	0.2	-1.0	0.5	2.0	0.7	1.8	0.0	-0.2	0.6	1.8
Whole body water mass	0.9	5.4	10.2	2.7	2.9	-3.0	-0.1	0.7	2.1	3.2	2.2	2.8	-1.2
Leg predicted mass (right)	0.7	3.8	7.7	2.1	2.1	-2.7	-0.1	0.2	2.2	2.8	1.3	2.5	-0.5
Arm fat mass (left)	0.2	1.0	3.1	1.2	0.5	0.0	-0.1	-1.2	1.8	1.1	0.5	1.3	0.2
Number of self-reported non-cancer illnesses	0.6	1.0	8.2	0.5	1.0	-0.5	0.4	2.9	0.2	0.0	-0.0	-0.3	0.3
Average weekly champagne plus white wine intake	0.3	0.4	1.7	-0.4	0.5	-0.6	-0.1	1.3	-0.5	0.4	-0.1	0.1	-1.2
Miserableness	1.4	2.4	4.5	1.5	2.0	-1.7	1.2	0.9	1.6	2.1	1.6	1.4	-1.3
Guilty feelings	1.4	2.1	5.5	2.0	1.7	-0.5	0.2	2.3	1.1	1.2	1.7	1.6	0.3
Wears glasses or contact lenses	4.5	5.2	11.8	3.4	2.7	-1.0	-0.7	1.4	2.5	2.9	2.4	3.0	0.0
Ever taken oral contraceptive pill	0.7	0.8	2.0	-1.4	-1.1	-0.1	-0.2	-0.3	-0.8	-0.9	-1.2	-0.9	0.7
Hearing aid user	1.4	1.6	3.4	1.4	1.6	-1.1	0.5	-1.8	0.9	1.7	1.0	1.3	0.4
Mother’s age at death	0.3	0.3	1.0	-0.3	-0.2	-0.5	0.4	1.0	-1.0	0.3	-0.7	-0.4	0.3
Financial situation satisfaction	0.5	0.6	1.9	-0.6	0.4	-1.2	0.9	-0.6	-0.4	0.2	-0.1	-0.6	-1.4
Tinnitus: Yes, now most or all of the time	2.3	2.7	8.3	-2.1	-2.2	-0.4	-0.5	-0.6	-0.7	-1.5	-2.9	-2.0	1.2
Commuting to job workplace: Public transport	2.5	3.0	8.2	-2.3	-1.5	0.7	-0.2	-1.2	-2.9	-2.3	-1.6	-2.1	0.4
Eye problems/disorders: Glaucoma	2.5	2.9	5.7	-1.6	-1.9	1.7	-0.6	-1.9	-2.4	-1.9	-1.3	-2.3	0.2
Medication: Blood pressure	0.2	0.4	1.5	0.2	-0.0	1.2	-0.4	1.0	0.6	-0.7	0.5	0.4	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.4	0.1	0.8	-1.0	-0.1	-0.4	-0.3	0.8	0.4	0.6	-1.2
Supplements: Fish oil (including cod liver oil)	3.2	4.1	7.5	2.7	2.2	-2.2	-0.4	1.5	2.5	2.7	2.0	2.1	0.3
High cholesterol (Self-reported)	1.1	2.0	4.2	1.4	2.0	-1.9	-0.3	1.6	0.9	1.8	0.8	1.4	-0.5
Medication: Bendroflumethiazide	0.5	0.8	2.5	-0.4	-1.1	1.4	-0.0	1.6	0.1	-1.3	-0.7	-0.1	0.6
Medication: Paracetamol	0.9	1.4	3.9	0.7	1.6	-2.0	1.6	0.1	-1.3	0.5	1.2	0.8	0.1
Medication: Lisinopril	1.1	1.4	4.1	-0.8	-1.3	1.9	-0.4	0.0	-0.5	-1.5	-0.2	-1.0	2.0
Medication: Atorvastatin	1.1	1.4	3.9	1.3	2.0	-1.0	-0.4	1.2	1.5	1.4	0.8	0.8	-0.1
Illnesses of father: High blood pressure	0.9	1.1	5.4	0.9	0.3	2.3	0.4	-0.8	0.4	0.0	1.0	0.7	-1.4
Alcohol drinker status: Never	0.7	0.8	1.7	-0.9	-1.1	0.4	-0.2	1.1	0.6	-0.9	-1.3	-0.7	1.3
Ever smoked	1.2	2.0	15.8	0.3	0.9	0.2	-0.2	-4.0	-0.9	-0.0	1.2	0.3	-1.0
Basal metabolic rate	0.9	4.9	9.3	2.6	2.8	-2.7	-0.1	0.4	2.2	3.0	2.0	2.8	-1.0
Leg fat percentage (left)	0.4	1.4	3.0	1.3	1.0	-0.5	-0.6	-1.7	1.5	1.5	0.7	1.7	-0.4
Arm fat-free mass (left)	1.2	6.2	11.8	2.7	3.1	-3.4	-0.4	0.7	2.1	3.4	2.3	2.9	-1.7
Number of operations (self-reported)	0.5	0.7	1.7	-0.8	-0.7	0.5	0.4	0.6	-1.1	-0.7	-1.3	-0.9	1.0
Average weekly beer plus cider intake	1.5	2.1	6.5	-1.6	-0.8	0.7	-0.2	1.0	-2.6	-1.9	-1.0	-2.1	-0.9
Irritability	1.2	2.1	5.8	2.1	1.7	0.3	0.2	0.1	1.3	1.8	2.4	1.6	-0.6
Risk taking	0.1	0.2	1.3	-0.0	0.5	-0.2	0.1	-0.4	-0.0	0.5	0.4	0.2	-1.2
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.9	0.4	0.3	-0.2	0.0	-1.1	0.2	0.6	0.3	0.6	-1.4
Fractured/broken bones in last 5 years	0.4	0.6	1.8	0.6	0.4	0.9	-0.6	-1.4	0.3	0.3	1.3	0.5	-0.3
Age started oral contraceptive pill	1.0	1.2	3.1	-1.6	-0.9	-1.1	0.1	0.3	-1.1	-1.3	-1.8	-1.0	0.5
Diastolic blood pressure, automated reading	0.2	0.5	2.1	-0.6	-0.8	-0.1	-0.0	0.7	0.9	-0.7	-1.4	-0.3	0.8
Ever depressed for a whole week	0.8	1.0	5.4	-0.7	0.1	-0.2	0.2	-0.3	-1.6	-0.8	-0.2	-0.9	-2.3
Unable to work because of sickness or disability	0.6	0.7	4.8	0.1	0.0	-0.4	-0.7	2.2	-0.2	-0.1	-0.4	-0.1	1.2
Commuting to job workplace: Cycle	0.4	0.4	1.7	0.3	0.1	-1.3	1.1	-0.7	0.2	0.7	-0.4	0.2	-0.1
Myopia	2.8	4.1	9.4	-1.5	-3.1	2.3	-1.3	0.7	0.4	-2.1	-2.7	-1.3	2.9
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.4	-1.6	-1.2	-0.4	0.5	-0.9	-1.5	-0.7	-1.4	-1.1	-0.2
Cholesterol lowering medication	0.6	0.9	5.8	-0.2	0.1	-0.4	-1.1	2.4	-0.1	-0.6	-0.9	0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.7	1.1	1.5	-0.3	-0.6	0.1	0.4	0.7	1.7	0.5	-0.2
Pain experienced in last month	0.8	1.3	3.4	-1.2	-1.8	0.9	1.1	-0.0	0.9	-0.9	-1.8	-1.0	0.2
Supplements: Calcium	2.3	2.6	4.4	-2.0	-1.8	0.9	-1.1	1.1	-1.4	-2.1	-1.8	-1.9	1.4
Basal cell carcinoma (self-reported)	7.0	8.3	17.2	3.2	4.1	-3.3	0.2	-0.9	2.1	3.6	2.8	4.1	-1.3
Heart attack/myocardial infarction (self-reported)	0.2	0.3	1.6	0.1	0.4	0.1	0.4	1.3	0.2	-0.4	-0.1	0.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.9	-0.9	-1.0	0.5	0.0	1.5	-0.5	-0.7	-1.1	-1.2	1.7
Heart disease (siblings)	0.9	1.2	2.6	1.4	1.4	-0.7	0.4	0.6	0.8	1.4	1.0	1.6	0.6
Alcohol drinker status: Previous	0.6	0.7	2.7	0.4	0.3	0.2	-1.5	1.1	-0.0	0.4	0.5	0.4	-1.6
Pack years of smoking	0.2	0.3	0.7	0.6	0.2	0.2	-0.6	-0.1	0.3	0.8	0.6	0.6	-0.7
Impedance of whole body	3.3	16.9	33.2	-5.5	-4.4	3.1	-0.8	-1.9	-5.8	-5.6	-4.1	-4.9	-0.2
Leg fat mass (left)	0.5	2.0	4.0	1.6	1.5	-1.2	-0.3	-1.4	1.8	2.0	0.9	2.0	-0.6
Arm predicted mass (left)	1.1	5.6	11.0	2.6	3.0	-3.1	-0.5	0.7	1.9	3.3	2.2	2.8	-1.7