TWAS hub - PSPC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.110	0.0513	4.7e-04	0.015	NA	0.001	NA	0.017	2.3e-02	NA	2.4e-01	NA	1.6e-02
2	GTEx	Cells EBV-transformed lymphocytes	0.280	0.1110	5.5e-03	-0.009	NA	0.013	NA	-0.008	9.8e-01	NA	1.2e-01	NA	7.9e-01
3	GTEx	Cells Transformed fibroblasts	0.059	0.0290	7.6e-03	0.043	NA	0.040	NA	0.025	3.5e-04	NA	5.2e-04	NA	5.4e-03
4	GTEx	Nerve Tibial	0.106	0.0306	6.9e-08	0.084	NA	0.083	NA	0.125	1.5e-06	NA	1.7e-06	NA	3.8e-09
5	GTEx	Testis	0.273	0.1040	2.1e-04	0.093	NA	0.217	NA	0.222	6.6e-05	NA	5.3e-10	NA	3.3e-10
6	GTEx	Thyroid	0.112	0.0400	1.1e-04	0.044	NA	0.017	NA	0.022	2.4e-04	NA	1.8e-02	NA	7.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Headache pain in last month	4.5	7.7	13.4	-3.2	-0.7	-2.8	-3.7	-1.6	-3.4
Stomach or abdominal pain in last month	4.3	5.4	7.6	-1.9	-1.8	-2.7	-2.4	-2.3	-2.8
Worry too long after embarrassment	4.3	7.2	16.5	-4.1	-1.6	-2.9	-2.8	-2.1	-2.0
Leg fat percentage (left)	4.3	15.4	41.5	-2.1	-1.3	-4.2	-4.9	-1.9	-6.4
Pain experienced in last month	4.2	7.0	13.2	3.5	-1.1	2.5	3.6	1.2	2.8
Leg fat percentage (right)	4.0	14.3	37.6	-2.1	-1.3	-4.0	-4.8	-1.7	-6.1
Body fat percentage	3.8	15.0	40.3	-2.3	-1.0	-4.6	-4.4	-1.7	-6.3
Ever used hormone-replacement therapy (HRT)	3.6	4.5	7.3	2.5	0.9	2.7	2.5	1.6	2.0
Trunk fat percentage	3.3	13.3	35.5	-2.3	-0.7	-4.3	-4.1	-1.7	-6.0
Age at First Birth	3.2	4.7	7.7	1.6	0.7	2.0	2.6	2.6	2.8
Suffer from ‘nerves’	3.2	5.0	8.4	-2.1	-0.2	-2.9	-1.8	-2.8	-2.4
Primary Biliary Cirrhosis	3.0	4.2	12.3	-1.7	0.1	-1.8	-3.5	-1.1	-2.5
Medication: Ramipril	3.0	3.9	8.2	-2.1	-0.9	-2.9	-1.7	-0.9	-2.5
Average weekly beer plus cider intake	3.0	4.4	6.3	-2.0	-1.8	-2.1	-2.5	-2.0	-2.0
Mouth/teeth dental problems	2.8	4.3	9.0	1.1	0.1	2.1	2.9	1.6	3.0
Lung FEV1/FVC ratio	2.7	13.8	20.2	4.4	1.6	3.7	4.5	3.3	4.0
Arm fat percentage (right)	2.7	10.6	27.9	-1.8	-0.8	-3.8	-3.9	-1.4	-5.3
Hayfever/allergic rhinitis (self-reported)	2.6	3.5	5.9	1.0	2.0	1.8	1.9	2.4	1.8
Illnesses of mother	2.5	3.1	5.3	1.8	0.7	2.3	1.4	1.5	2.3
Arm fat percentage (left)	2.5	9.9	26.9	-1.8	-0.8	-3.6	-3.7	-1.1	-5.2
Ever taken oral contraceptive pill	2.5	2.8	5.2	1.9	0.6	1.7	1.5	2.3	1.6
High blood pressure (mother)	2.4	3.4	4.7	-2.2	-0.1	-2.1	-2.1	-1.6	-2.1
Father’s age at death	2.4	3.2	11.3	1.3	-0.8	1.8	3.4	0.9	1.3
Health satisfaction	2.4	3.1	9.7	1.9	-0.7	1.8	0.7	3.1	1.0
Ever had bowel cancer screening	2.4	2.8	6.9	-0.4	0.6	-1.6	-2.1	-1.6	-2.6
Commuting to job workplace: Public transport	2.4	2.9	7.3	0.4	-0.5	1.8	2.1	1.5	2.7
Cholesterol lowering medication	2.4	3.6	6.5	-1.7	0.3	-2.3	-1.3	-2.2	-2.5
Tinnitus: Yes, now most or all of the time	2.3	2.7	5.3	1.0	1.1	1.5	2.3	1.2	2.3
Heel T-Score	2.2	17.8	27.4	-3.9	-3.0	-5.2	-4.1	-4.2	-4.6
High blood pressure	2.2	6.2	15.3	-1.5	0.2	-3.3	-2.8	-0.9	-3.9
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	5.1	-1.5	-0.7	-2.3	-1.8	-1.8	-1.3
Worrier / anxious feelings	2.2	4.2	9.7	-3.1	-1.5	-2.3	-1.9	-1.6	-1.1
Leg fat mass (right)	2.2	8.7	24.4	-1.2	-1.6	-3.1	-3.7	-0.4	-4.9
Chest pain or discomfort	2.2	3.2	5.0	-1.6	0.7	-1.6	-2.2	-2.1	-2.0
Leg fat mass (left)	2.2	8.7	25.1	-1.2	-1.6	-3.1	-3.7	-0.4	-5.0
Trunk fat mass	2.1	8.9	26.0	-1.7	-1.1	-3.4	-3.3	-0.8	-5.1
Medication: Blood pressure	2.1	3.8	6.8	-1.8	-0.0	-2.6	-2.6	-1.2	-2.2
Body Mass Index (BMI) (2010)	1.9	2.5	4.5	-1.3	-2.1	-1.8	-0.9	-1.4	-1.7
Medication for hormone replacement therapy	1.9	2.1	6.2	2.3	0.4	0.7	2.5	0.7	0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.2	8.5	-2.4	-2.1	-2.9	-1.7	-0.6	-2.0
Mouth/teeth dental problems: Bleeding gums	1.9	2.5	7.0	-1.0	-0.4	-1.4	-1.3	-2.6	-1.8
Wheeze or whistling in the chest in last year	1.9	3.3	6.7	-1.8	-1.3	-1.2	-2.6	-1.9	-1.9
Mouth/teeth dental problems: Loose teeth	1.9	2.3	7.6	-0.9	-1.0	-1.4	-1.5	-0.3	-2.8
Pain type(s) experienced in last month: Hip pain	1.9	2.4	3.7	-1.9	1.6	-1.2	-1.9	-0.9	-1.5
Vascular/heart problems diagnosed by doctor	1.9	5.2	12.5	1.3	-0.1	3.3	2.4	0.9	3.5
Worry (Nagel 2018)	1.8	3.8	6.9	-2.3	-1.0	-2.6	-1.4	-1.8	-2.1
Respiratory disease	1.8	4.0	8.7	-1.6	-2.0	-2.2	-1.9	-0.8	-3.0
Sensitivity / hurt feelings	1.8	3.2	6.2	-2.5	-1.8	-2.0	-1.0	-1.7	-1.1
Commuting to job workplace: Car/motor vehicle	1.8	2.0	3.7	-0.5	-0.3	-1.8	-1.7	-1.5	-1.9
Severe depression (siblings)	1.7	1.9	2.6	-1.6	1.2	-1.3	-1.3	-1.5	-1.2
Hearing difficulty/problems with background noise	1.7	2.7	5.1	-1.7	-0.1	-2.3	-1.8	-1.0	-2.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	4.1	-1.9	-1.1	-0.8	-2.0	-1.2	-0.9
Whole body fat mass	1.7	7.2	21.3	-1.3	-1.2	-3.1	-3.1	-0.3	-4.6
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	4.5	1.6	0.4	1.5	1.2	2.1	0.9
Had menopause	1.6	2.0	4.1	2.0	-0.9	1.9	0.7	1.6	0.3
Medication: Simvastatin	1.6	2.3	5.3	-1.3	0.3	-1.8	-0.7	-1.8	-2.3
Pulse wave reflection index	1.6	2.0	4.3	-1.4	-0.7	-1.2	-1.5	-2.1	-1.2
Shortness of breath walking on level ground	1.6	2.0	4.6	1.3	-0.7	2.1	0.2	1.5	1.6
Hypertension (Self-reported)	1.6	4.4	11.1	-1.0	0.2	-2.9	-2.4	-0.5	-3.3
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.1	1.7	0.9	1.4	1.6	-0.3	1.8
Cardiovascular Disease	1.5	4.8	11.3	-1.2	-0.6	-3.1	-2.3	-1.2	-3.4
Diabetes (mother)	1.5	1.9	3.8	-2.0	0.6	-1.7	-1.5	0.1	-1.5
Waist circumference	1.5	5.4	15.1	-1.2	-1.7	-2.4	-2.6	-0.3	-3.9
Medication: Bendroflumethiazide	1.5	2.2	4.7	-1.2	1.2	-2.2	-0.6	-1.4	-1.8
Ever depressed for a whole week	1.5	1.8	3.4	0.7	1.4	1.5	1.2	1.2	1.8
Ovarian Cancer	1.4	1.9	5.5	-2.3	-0.8	-0.8	-1.4	-1.6	-0.5
Pack years adult smoking proportion	1.4	2.1	5.6	-0.9	1.5	-0.5	-2.4	-0.7	-1.9
Number of incorrect matches in round	1.4	2.3	3.5	1.7	1.5	1.6	1.6	1.9	0.4
Asthma	1.4	2.8	3.7	-1.7	-1.9	-1.9	-1.3	-1.5	-1.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.8	1.4	0.0	2.2	1.9	0.9	1.6
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.8	-1.2	-0.4	-0.9	-1.8	-0.2	-2.2
Birth weight	1.4	3.0	4.2	1.2	1.7	2.0	1.5	1.8	2.0
Leg pain on walking	1.4	1.8	3.8	2.0	-1.2	1.1	0.9	1.7	0.6
High cholesterol (Self-reported)	1.4	2.4	4.8	-1.3	-1.2	-2.1	-1.1	-0.9	-2.2
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.0	-1.5	-1.7	-2.2	-1.5	-1.1	-1.9
Mouth/teeth dental problems: Dentures	1.3	2.2	4.5	-0.6	0.1	-1.8	-2.0	-1.0	-2.1
Arm fat mass (right)	1.3	5.2	15.3	-1.0	-0.9	-2.5	-2.8	-0.1	-3.9
Peak expiratory flow (PEF)	1.3	3.0	10.3	1.5	0.6	0.7	3.2	1.4	1.6
Qualifications: College or University degree	1.3	4.2	14.3	-1.7	-1.8	1.6	1.1	1.0	3.8
Comparative height size at age 10	1.3	7.2	13.9	1.9	0.1	2.9	2.9	3.7	3.0
Diabetes diagnosed by doctor	1.3	2.1	4.1	-1.2	-1.8	-2.0	-1.1	-0.1	-1.7
Asthma (self-reported)	1.3	2.7	3.7	-1.6	-1.9	-1.7	-1.3	-1.5	-1.6
Mother’s age at death	1.3	1.7	4.6	0.9	0.0	1.5	2.1	1.1	1.1
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.4	-1.8	1.6	-1.1	-0.6	-1.2	0.0
Neuroticism (Nagel 2018)	1.2	2.9	4.4	-2.0	-1.2	-2.1	-1.6	-1.0	-1.9
Alzheimer’s Disease (in father)	1.2	1.3	5.0	0.8	-2.2	1.1	0.9	0.4	0.3
Coronary Artery Disease (CAD)	1.2	1.5	3.9	-0.4	-0.6	-1.3	-0.7	-1.5	-2.0
Mean Putamen Volume	1.2	1.4	4.1	-2.0	-0.5	-1.0	-1.7	-0.0	-0.2
Chronic bronchitis/emphysema (father)	1.2	1.4	3.6	0.4	1.1	-1.4	-0.9	-0.8	-1.9
Body mass index (BMI)	1.2	5.1	15.2	-0.7	-1.1	-2.3	-2.9	0.3	-3.9
Qualifications: None of the above	1.2	2.5	8.1	0.2	-0.3	-0.8	-2.1	-1.2	-2.8
Age at first live birth	1.2	2.2	4.0	0.8	-0.0	1.7	1.7	1.6	2.0
Medication: Ibuprofen	1.2	1.5	2.3	0.2	-1.5	1.3	0.8	1.4	1.5
Knee pain experienced in last month	1.2	1.8	4.4	-0.9	-0.4	-1.7	-1.5	0.5	-2.1
Arm fat mass (left)	1.2	5.0	15.3	-0.9	-1.0	-2.4	-2.7	0.1	-3.9
Risk taking	1.2	1.7	4.2	0.2	-0.6	1.6	0.7	2.0	1.6
Age started oral contraceptive pill	1.2	1.5	3.9	-0.6	-1.7	-0.8	-0.6	-2.0	-1.0
Fasting Glucose	1.1	1.3	4.0	-0.8	-2.0	-0.8	-0.3	-1.4	-0.6
Medication: Metformin	1.1	1.5	3.7	-0.6	-1.2	-1.9	-0.7	0.1	-1.7
Maternal smoking around birth	1.1	1.6	5.5	-0.6	-2.3	-1.0	-1.5	0.1	-0.9
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.2	-1.3	-0.2	-1.0	-1.5	-1.2	-1.2
Pain all over the body in last month	1.1	1.2	4.3	0.3	0.6	-0.0	-2.1	0.9	-1.3
Alcohol drinker status: Never	1.1	1.3	3.6	1.3	-0.7	1.0	1.9	0.5	1.0
Pack years of smoking	1.1	1.6	4.5	-0.6	1.4	-0.1	-2.1	-0.4	-1.7
Relative age of first facial hair	1.0	2.0	4.2	-2.0	0.9	-1.7	-0.9	-1.7	-0.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.0	0.5	0.6	1.1	0.4	2.0	1.0
Hip circumference	1.0	4.5	11.1	-1.1	-1.5	-2.5	-2.4	-0.4	-3.3
Hair/balding pattern: Pattern 3	1.0	1.5	3.1	1.8	0.6	0.5	1.6	1.6	-0.0
Medication: Lansoprazole	1.0	1.2	3.7	-0.8	-0.6	-1.1	-0.6	-0.7	-1.9
Medication: Seretide 50 evohaler	1.0	1.1	2.2	-1.2	-1.5	-0.8	-0.9	-1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	3.0	0.1	0.6	1.7	0.5	1.1	1.5
Medication: Lisinopril	1.0	1.3	2.2	0.1	0.8	-0.8	-1.4	-1.4	-1.5
Fractured/broken bones in last 5 years	1.0	1.2	5.1	-2.3	0.7	-1.0	-0.8	-0.4	0.2
Diastolic blood pressure, automated reading	1.0	3.0	6.2	-1.4	-1.2	-2.2	-1.6	-1.0	-2.5
Ever had hysterectomy (womb removed)	0.9	1.0	3.0	0.0	0.1	-0.7	-0.9	-1.4	-1.7
Vitamin and mineral supplements	0.9	1.3	3.4	-0.0	-0.9	-0.9	-1.2	-1.8	-1.1
Had other major operations	0.9	1.2	2.8	0.9	-0.1	1.7	0.6	1.6	0.8
Lung cancer (father)	0.9	1.1	2.6	1.1	0.7	1.3	-0.5	1.6	-0.6
Migraine (self-reported)	0.9	1.1	2.4	-0.5	-1.0	-0.7	1.6	0.9	1.3
Overall health rating	0.9	2.0	4.6	-0.5	-1.3	-1.0	-1.9	0.8	-2.1
Commuting to job workplace: Walk	0.9	1.0	2.7	-0.1	0.2	0.8	1.0	1.6	1.3
Osteoporosis (self-reported)	0.9	1.1	3.6	0.3	-0.2	0.9	1.5	-0.1	1.9
Miserableness	0.9	1.6	4.0	-0.4	-0.5	-1.9	-0.8	-1.0	-2.0
Medication: Blood pressure	0.9	1.8	5.0	-0.5	1.5	-1.2	-1.2	0.2	-2.2
Schizophrenia vs Biploar Disorder	0.8	1.0	3.3	-1.8	0.4	-1.0	-0.0	-1.2	0.4
Verbal and Numeric Reasoning (VNR)	0.8	1.9	3.5	1.2	-0.6	1.6	1.3	1.4	1.9
Bipolar Disorder (2011)	0.8	0.8	2.0	1.1	0.0	0.9	0.8	1.4	0.4
HbA1C	0.8	0.9	1.8	-0.5	-0.6	1.1	0.7	1.2	1.3
HDL Cholesterol	0.8	1.3	3.2	1.6	1.1	0.2	-0.6	-0.6	-1.8
Chronotype (morning person)	0.8	1.8	4.0	-0.3	-2.0	-1.6	-0.8	-0.7	-1.7
Systolic blood pressure, automated reading	0.8	2.3	4.8	-1.0	-1.1	-1.9	-0.7	-1.7	-2.2
Taking other prescription medications	0.8	1.3	3.1	-1.4	1.3	-0.5	-1.8	0.4	-0.6
Hair/balding pattern: Pattern 2	0.8	1.1	2.0	-1.3	-1.3	-0.3	-1.4	-1.0	0.0
Neuroticism score	0.8	1.6	2.3	-1.5	-0.7	-1.5	-1.2	-1.1	-1.3
Impedance of arm (right)	0.8	3.8	10.9	-1.6	1.9	-1.9	-1.3	-3.3	-0.8
Length of working week for main job	0.8	0.9	2.4	0.2	-0.8	0.9	0.2	1.2	1.6
High blood pressure (siblings)	0.8	1.1	2.2	1.2	-1.4	0.8	0.3	1.5	-0.5
Exposure to tobacco smoke outside home	0.8	1.1	2.4	-0.4	-1.4	-0.1	-1.5	-0.7	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	1.5	-0.8	0.4	-1.2	-1.1	-1.2	-1.2
Friendships satisfaction	0.8	1.0	2.3	-1.2	-1.5	-1.3	0.2	-0.3	0.5
Qualifications: nursing, teaching	0.8	1.3	3.4	0.6	-0.9	0.8	1.8	0.2	1.6
Hearing aid user	0.8	0.9	2.7	0.1	-1.6	0.2	0.7	0.4	1.4
Supplements: Calcium	0.8	0.9	2.2	0.1	-0.2	1.4	0.9	0.4	1.5
Alcohol drinker status: Previous	0.8	0.9	2.3	1.1	0.7	0.4	1.5	0.8	0.7
Ulcerative Colitis (UC)	0.7	1.3	4.3	0.5	-0.6	0.6	1.2	2.1	1.1
Reaction Time	0.7	1.4	4.7	0.2	-0.6	-1.1	-0.9	-1.0	-2.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	3.0	0.3	-0.7	0.3	-0.3	1.0	-1.7
BMI	0.7	4.3	12.4	-0.1	-1.7	-1.7	-2.4	1.6	-3.5
Systolic Blood Pressure	0.7	3.4	6.7	-1.0	-0.7	-2.6	-1.0	-2.5	-2.3
Townsend deprivation index at recruitment	0.7	0.9	2.5	0.4	1.0	-0.0	-1.6	0.2	-1.3
Age when periods started (menarche)	0.7	1.7	4.7	1.0	-2.2	0.6	1.4	-0.8	1.1
Diabetes (self-reported)	0.7	1.0	2.6	-0.3	-1.6	-1.5	-0.0	-0.0	-1.1
Time employed in main current job	0.7	0.8	2.8	-0.9	-0.5	0.3	0.2	1.7	1.0
Falls in the last year	0.7	0.9	2.8	1.7	0.3	-0.1	-0.1	1.1	-1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	7.2	0.5	1.1	0.3	2.7	0.1	2.1
Impedance of arm (left)	0.7	3.2	7.3	-2.0	1.9	-1.8	-1.0	-2.7	-0.6
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.7	-1.3	0.7	-0.6	-0.2	-1.9	-0.4
Mean time to correctly identify matches	0.7	1.3	4.8	0.7	-0.6	-1.0	-0.7	-0.8	-2.2
Medication for cholesterol	0.7	1.0	3.5	-0.5	-1.2	0.7	-0.3	0.4	1.9
Medication: Gliclazide	0.7	0.8	2.2	0.1	-1.5	-1.0	-0.3	-0.2	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.9	1.0	0.6	0.3	1.6	-1.1	2.0
Medication: Atorvastatin	0.7	0.8	1.5	0.8	0.6	0.8	0.7	1.1	1.2
Illnesses of father: High blood pressure	0.7	0.8	1.7	-0.9	0.8	-1.3	-0.8	0.8	-0.7
Commuting to job workplace: Cycle	0.7	0.8	2.7	-0.1	-0.6	0.7	0.9	-0.6	1.6
Depressed Affect (Nagel 2018)	0.6	1.2	3.0	-0.6	-1.2	-1.1	-1.2	0.2	-1.7
Intelligence (Savage-Jansen 2018)	0.6	1.9	3.5	1.3	-0.2	1.9	1.0	1.9	1.2
Alzheimer’s Disease (including proxy)	0.6	0.8	2.8	0.0	-1.7	0.6	0.9	-0.0	1.0
Major Depression (MDD)	0.6	0.8	1.2	-0.9	0.6	-0.9	-1.0	-1.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.7	-0.4	-1.9	-1.0	-0.6	0.8	-0.7
Neuroticism	0.6	1.5	2.5	-1.6	-0.7	-1.3	-1.1	-0.8	-1.5
Hand grip strength (left)	0.6	1.5	4.4	-0.5	1.1	0.3	1.3	-1.2	2.1
Number of treatments/medications taken	0.6	1.1	2.3	-1.2	0.9	-0.9	-1.1	-0.1	-1.5
Financial difficulties in last 2 years	0.6	0.7	1.9	1.1	0.8	-0.3	-0.2	-0.8	-1.4
Trunk fat-free mass	0.6	3.2	8.0	1.2	-1.3	1.5	1.9	2.8	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	3.7	-0.0	-0.0	0.1	-1.0	1.9	-1.1
Number of live births	0.6	0.9	3.4	-0.3	0.5	-0.7	0.1	-1.8	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	2.1	-0.9	-1.5	0.2	-0.0	0.7	1.1
Trunk predicted mass	0.6	3.5	8.4	1.3	-1.3	1.7	2.0	2.9	1.6
Arm fat-free mass (right)	0.6	3.0	10.4	1.0	-1.8	1.3	1.2	3.2	0.7
Emphysema/chronic bronchitis	0.6	0.6	1.8	0.3	0.1	0.5	-1.4	-0.3	-1.2
Medication: Omeprazole	0.6	0.7	1.4	0.1	1.2	1.2	-0.2	1.0	0.5
Number of full sisters	0.6	0.7	1.7	0.7	-1.3	0.5	1.1	-0.5	0.3
Illnesses of father: Heart disease	0.6	0.8	1.4	-1.2	-0.8	-0.1	-0.8	1.2	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.0	-1.0	0.1	-0.6	-1.4	0.3	-0.8
Wears glasses or contact lenses	0.6	0.7	1.5	1.2	0.8	1.2	-0.1	0.8	0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.7	0.2	1.3	1.1	-0.8	0.9	0.2
Basal cell carcinoma (self-reported)	0.6	0.7	3.6	-0.4	-1.9	-0.2	-0.4	-0.0	-0.4
LDL Cholesterol	0.5	0.8	3.3	-0.1	0.1	-0.8	0.0	-1.8	-0.8
Neuroticism (2016)	0.5	0.7	2.0	-1.0	-0.5	-1.4	-0.6	-0.1	-0.9
Blood White Count	0.5	3.8	11.7	1.9	1.6	2.2	0.4	3.4	0.5
Hypothyroidism (self reported)	0.5	1.2	2.0	-1.1	1.4	-0.7	0.5	-1.3	1.2
Average weekly fortified wine intake	0.5	0.6	2.4	-0.2	1.6	0.2	0.1	-1.0	0.1
Multivitamins +/- minerals	0.5	0.6	1.3	0.1	0.7	0.9	0.5	1.0	1.1
Supplements: Glucosamine	0.5	0.6	2.3	-0.4	1.5	0.4	-0.8	0.0	0.8
Impedance of leg (left)	0.5	2.5	9.1	-1.0	0.2	-1.4	-1.1	-3.0	-1.3
Nervous feelings	0.5	1.0	2.0	-1.1	0.2	-1.4	-0.4	-1.3	-0.8
Weight	0.5	2.7	7.8	-0.7	-1.0	-1.7	-1.8	0.9	-2.8
Depression (self-reported)	0.5	0.6	1.2	-1.1	0.5	-1.0	-0.1	-0.6	-0.7
Exposure to tobacco smoke at home	0.5	0.5	1.1	-0.9	-1.0	-0.4	-0.6	0.0	-0.8
Tense / ‘highly strung’	0.5	0.8	1.9	-1.3	-0.9	-1.4	-0.1	0.4	-0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	-0.7	-0.7	-0.3	-1.1	-0.5	-1.0
Loud music exposure frequency	0.5	0.6	1.6	1.2	-1.0	0.0	0.4	-0.8	-0.5
Number of children fathered	0.5	0.6	2.6	-0.1	-1.6	-0.6	0.0	-0.6	-0.6
Neck or shoulder pain in last month	0.5	0.7	2.0	-1.4	0.4	-0.7	-1.1	-0.8	-0.1
Arm predicted mass (right)	0.5	2.5	9.1	0.9	-1.5	1.2	1.2	3.0	0.6
Alcohol intake frequency.	0.5	1.1	2.8	0.9	1.2	0.2	1.1	1.7	0.2
Had major operations	0.5	0.6	1.7	-0.6	0.2	-1.1	-0.4	-0.5	-1.3
Age at last live birth	0.5	0.8	3.2	-0.6	-0.2	0.7	0.6	0.0	1.8
Loneliness, isolation	0.5	0.8	2.2	-0.7	-0.1	-0.4	-1.5	-0.3	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.7	-1.2	-0.4	-0.2	-1.3	-1.0	-0.4
Breast cancer (self-reported)	0.5	0.6	1.3	-0.4	1.2	-0.4	-1.0	-0.8	-0.4
Osteoarthritis (self-reported)	0.5	0.6	2.5	-0.5	0.9	-0.3	-0.1	1.6	-0.4
Illnesses of father: None of the above (group 1)	0.5	0.7	2.8	0.2	0.9	0.5	0.3	-1.7	0.3
Financial situation satisfaction	0.5	0.6	1.5	0.5	-1.0	-0.9	-0.1	-0.5	-1.2
Ever smoked	0.5	0.9	2.1	1.4	0.6	0.5	1.1	1.3	0.3
Impedance of whole body	0.5	2.6	8.0	-1.6	1.0	-1.5	-1.0	-2.8	-0.8
Waist Hip Ratio (WHR)	0.4	1.9	3.3	-1.2	-0.6	-0.9	-1.7	-1.6	-1.8
Lung FVC	0.4	2.1	5.2	-1.0	1.6	-1.8	0.5	-2.3	-0.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.6	-0.2	-1.2	-0.5	0.5	0.7	-0.6
Medication: Co-codamol	0.4	0.5	1.7	0.2	0.6	0.7	-0.5	1.3	-0.2
Fed-up feelings	0.4	0.8	2.6	-0.4	-0.1	-0.9	-0.9	0.6	-1.6
Hayfever, allergic rhinitis or eczema	0.4	0.8	3.4	0.3	1.8	0.3	0.8	0.5	0.8
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.4	1.3	-0.4	-1.0	0.7	-0.6
Noisy workplace	0.4	0.5	2.0	0.5	-1.4	-0.1	0.1	0.7	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.9	-1.4	0.3	-0.2	-0.5	0.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.8	0.3	1.7	-0.2	1.9	-0.5	1.2
Medication: Paracetamol	0.4	0.6	1.2	-1.1	0.6	-0.0	-0.9	-1.1	0.3
Medication: Amlodipine	0.4	0.6	1.6	0.8	1.1	-0.5	-0.2	0.1	-1.3
Heart disease (mother)	0.4	0.5	1.7	0.0	0.3	-0.3	-0.3	-0.9	-1.3
Medication: Aspirin	0.4	0.6	1.4	1.2	0.5	0.1	0.7	1.0	-0.5
Supplements: Vitamin C	0.4	0.5	1.4	-1.2	-0.4	-0.4	-1.0	0.5	-0.4
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-0.6	0.6	-0.5	-1.1	-0.7	0.4
Whole body fat-free mass	0.4	2.0	7.2	0.8	-1.2	0.9	1.2	2.7	0.8
Long-standing illness, disability or infirmity	0.4	0.7	1.4	-1.2	-0.2	-1.0	-0.8	0.8	-0.6
Whole body water mass	0.4	2.2	8.1	0.8	-1.2	0.9	1.2	2.8	0.8
Number of self-reported non-cancer illnesses	0.4	0.6	2.6	-0.3	0.8	-0.6	-0.0	1.6	-0.5
Guilty feelings	0.4	0.6	2.6	-0.6	-0.5	-0.3	-0.3	-1.6	-0.1
Eye problems/disorders: Glaucoma	0.4	0.5	1.5	0.4	0.3	0.4	-0.5	1.2	-0.9
Number of operations (self-reported)	0.4	0.6	2.0	0.0	1.4	0.6	-0.7	0.7	-0.4
Irritability	0.4	0.6	1.3	0.2	1.1	-0.6	-0.6	-0.8	-1.0
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.9	0.7	0.9	0.8	1.0	-0.0	0.3
Depression (Nagel 2018)	0.3	0.4	1.1	-0.4	-1.0	-0.3	-0.3	-0.6	-0.8
Schizophrenia (2018)	0.3	0.6	2.2	-1.5	-0.4	-0.6	-0.9	0.1	-0.5
Alzheimer’s Disease (in mother)	0.3	0.3	1.2	0.0	-0.4	0.3	0.5	0.2	1.1
Prostate Cancer	0.3	0.4	0.8	-0.9	-0.1	-0.6	-0.8	0.6	-0.3
Triglycerides	0.3	0.5	1.5	-0.9	0.1	-0.6	0.2	-1.2	-0.3
Supplements: Zinc	0.3	0.4	1.6	0.0	1.2	0.4	-0.3	0.4	0.5
Impedance of leg (right)	0.3	1.7	6.7	-1.1	-0.2	-1.0	-0.8	-2.6	-0.7
Current tobacco smoking	0.3	0.5	1.8	-0.2	0.5	-0.2	-1.3	-0.2	-0.9
Qualifications: CSEs or equivalent	0.3	0.4	1.2	0.3	1.1	-0.7	0.0	0.0	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.2	-0.0	0.9	0.2	0.9	0.8
Medication: Levothyroxine sodium	0.3	0.6	1.8	-0.7	0.9	-0.5	0.2	-1.3	0.2
Sitting height	0.3	2.2	7.1	1.0	-1.1	0.6	2.7	1.1	1.5
Past tobacco smoking	0.3	0.6	2.5	-1.6	-0.1	-0.2	-0.4	-0.6	0.5
Heart attack	0.3	0.3	0.7	0.6	0.8	0.6	0.8	-0.0	0.1
Fluid intelligence score	0.3	0.7	2.5	0.4	0.0	0.7	-0.0	1.6	0.9
Illnesses of siblings	0.3	0.4	0.8	-0.6	0.7	-0.2	0.8	-0.5	0.9
Standing height	0.3	2.9	6.7	0.4	-0.0	1.5	2.6	1.8	2.3
Birth weight of first child	0.3	0.6	1.8	-0.1	-1.3	0.5	-0.4	1.0	0.4
Blood clot in the leg (DVT)	0.3	0.3	0.7	0.2	0.8	-0.5	0.6	0.3	-0.7
Gout (self-reported)	0.3	0.4	1.7	0.0	1.3	0.1	-0.6	0.5	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.4	-0.4	0.7	-0.1	1.2	-0.7	1.1
Number of full brothers	0.3	0.3	1.4	0.7	0.1	-0.2	0.3	0.1	-1.2
Eye problems/disorders: None of the above	0.3	0.3	0.9	0.9	0.5	0.8	0.4	-0.3	0.1
Medication: Allopurinol	0.3	0.4	1.0	0.3	0.8	0.5	-1.0	-0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.9	-0.4	-0.1	0.1	1.2	0.6	1.4
Mood swings	0.3	0.6	1.3	-0.6	-0.0	-1.2	-0.7	-0.4	-1.0
Back pain experienced in last month	0.3	0.5	2.0	-0.6	1.4	-0.2	-0.1	-0.7	-0.1
Medication: Aspirin	0.3	0.4	1.1	1.0	0.5	0.0	0.4	0.8	-0.4
Arm fat-free mass (left)	0.3	1.7	6.1	0.7	-1.8	0.5	0.5	2.5	-0.2
Unable to work because of sickness or disability	0.3	0.4	0.8	0.9	-0.3	0.8	0.4	0.9	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.2	0.9	-0.6	0.4	0.2	-0.8
Arm predicted mass (left)	0.3	1.5	6.0	0.6	-1.4	0.6	0.5	2.5	-0.0
Bipolar Disorder (2018)	0.2	0.3	1.4	0.3	0.6	0.2	-0.3	1.2	0.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	-1.0	0.0	-0.2	-0.9	0.6	-0.4
Crohns Disease (2017)	0.2	0.5	1.7	-0.2	-1.3	-0.2	0.4	-0.7	0.7
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	-0.3	-1.3	-0.3	0.3	0.5	0.8
Breast Cancer	0.2	0.6	1.7	0.3	0.3	1.2	-0.3	1.3	0.2
Lupus	0.2	0.3	0.8	-0.6	-0.9	-0.1	0.1	-0.8	-0.3
Rheumatoid Arthritis	0.2	0.3	1.3	-0.2	-0.6	0.0	-0.2	-1.1	-0.3
Ulcerative Colitis	0.2	0.3	0.9	-0.3	-1.0	-0.0	0.0	-0.3	0.7
Blood Eosinophil Count	0.2	1.6	4.2	2.0	1.0	0.1	1.3	1.6	-0.0
Smoking Status	0.2	0.6	1.4	1.0	0.5	-0.0	-0.8	-0.2	-1.2
Allergy or Eczema	0.2	0.5	2.2	-0.1	1.5	-0.7	-0.1	-0.3	-0.1
Average weekly spirits intake	0.2	0.3	0.7	0.7	0.3	0.9	-0.1	0.4	0.4
Angina	0.2	0.3	1.2	0.3	-0.1	-0.5	-0.1	-1.1	-0.4
Leg fat-free mass (left)	0.2	1.1	5.5	0.2	-0.9	-0.1	0.2	2.3	-0.1
Hand grip strength (right)	0.2	0.6	1.9	-0.6	0.9	0.2	0.3	-0.6	1.4
Relative age voice broke	0.2	0.3	0.8	-0.9	-0.5	0.6	0.2	-0.4	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.5	-0.3	0.4	-0.3	0.1	-0.7
Medication: Atenolol	0.2	0.2	0.6	0.3	0.4	-0.4	-0.5	-0.2	-0.8
Leg predicted mass (left)	0.2	1.0	5.2	0.2	-0.8	-0.1	0.1	2.3	-0.1
Forced vital capacity (FVC)	0.2	0.8	2.1	-0.3	1.0	-0.4	1.4	-0.6	1.2
Pulse rate	0.2	0.3	1.3	0.0	-0.5	0.4	0.3	1.2	0.0
Happiness	0.2	0.2	1.0	-0.1	-0.2	-0.6	0.0	-0.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	-1.1	-0.4	0.1	0.3	-0.7	0.9
Medication: Cholesterol lowering	0.2	0.3	0.6	-0.6	-0.2	-0.6	-0.8	0.2	-0.6
Prospective memory result	0.2	0.2	0.6	0.3	-0.8	0.2	0.3	0.6	0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.7	-0.3	0.6	-0.4	0.3	0.5
Breastfed as a baby	0.2	0.2	0.8	0.4	0.9	0.3	0.5	0.0	-0.3
Hair/balding pattern: Pattern 4	0.2	0.5	2.0	-0.6	1.4	0.2	0.2	-0.7	0.3
Glaucoma (self-reported)	0.2	0.3	0.5	0.7	-0.1	0.6	0.2	0.6	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.8	1.9	-0.6	1.4	-1.1	0.7	-1.0	0.0
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.3	0.6	0.9	0.1	0.7	0.1
Pulse wave peak to peak time	0.2	0.2	0.6	0.8	0.4	-0.5	0.6	-0.2	-0.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	0.6	0.1	-0.4	1.0	-0.8	-0.4
Pulse rate, automated reading	0.2	0.8	2.2	0.4	-1.3	0.6	0.5	1.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.8	0.0	-0.6	-0.1	0.7	0.1	0.9
Smoking status: Previous	0.2	0.4	1.7	1.3	-0.0	0.4	0.3	0.4	-0.2
Leg fat-free mass (right)	0.2	1.1	6.0	0.4	-0.6	-0.0	0.4	2.4	-0.0
Average weekly red wine intake	0.2	0.2	0.5	0.3	0.5	0.5	0.3	0.4	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.5	-0.7	-0.2	0.1	-0.5	0.7	0.5
Smoking status: Current	0.2	0.4	1.3	0.0	0.1	-0.2	-1.1	-0.1	-1.0
Leg predicted mass (right)	0.2	1.0	5.7	0.4	-0.5	-0.0	0.3	2.4	-0.1
Average weekly champagne plus white wine intake	0.2	0.2	0.4	0.7	0.3	-0.0	0.6	-0.3	-0.7
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.7	0.8	-0.3	0.4	0.4	0.4	-0.2
Medication: Paracetamol	0.2	0.3	0.6	-0.8	0.4	0.5	-0.3	-0.3	0.6
Basal metabolic rate	0.2	1.2	5.7	0.4	-1.1	0.2	0.5	2.4	-0.1
Myopia	0.2	0.3	0.7	-0.6	0.7	-0.2	-0.2	-0.9	0.6
Heart disease (siblings)	0.2	0.2	0.6	0.1	-0.3	0.8	-0.4	0.6	0.1
Crohns Disease (2012)	0.1	0.2	0.4	0.1	-0.6	0.4	-0.0	0.6	0.2
Schizophrenia (2014)	0.1	0.3	1.1	-0.2	-0.3	0.3	-1.0	0.6	-0.2
Blood Red Count	0.1	1.2	5.6	0.5	0.1	-0.7	-0.7	0.8	-2.4
Tanning	0.1	1.5	3.0	-0.4	1.3	-0.9	-1.5	-1.0	-1.7
Hearing difficulty/problems: Yes	0.1	0.2	0.3	-0.1	-0.5	-0.1	-0.5	0.6	-0.1
Diabetes (father)	0.1	0.2	0.6	0.4	0.4	-0.1	0.4	0.8	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.7	0.0	-0.2	0.8	0.1	-0.0	0.7
Alcohol usually taken with meals	0.1	0.2	0.7	-0.1	0.8	-0.2	-0.0	0.1	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.8	-0.2	0.0	-0.2	0.5	0.9	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.5	0.5	0.3	-0.0	-0.5	0.1
Comparative body size at age 10	0.1	0.3	1.0	-0.5	0.6	-0.7	-1.0	-0.1	-0.3
Angina (self-reported)	0.1	0.2	0.6	0.6	0.1	-0.2	0.2	-0.8	-0.1
Family relationship satisfaction	0.1	0.1	0.3	-0.1	0.0	0.3	-0.1	0.6	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.5	0.0	0.7	-0.4	-0.2	0.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.6	0.0	0.2	0.3	-0.2	0.8	-0.1
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	0.5	-0.2	-0.2	0.5	0.3
Mineral and other dietary supplements	0.1	0.2	0.6	-0.3	-0.8	-0.1	0.1	0.3	-0.4
Blood Platelet Count	0.0	0.6	1.1	1.0	-0.6	0.7	1.0	0.4	0.6
Height	0.0	0.8	3.8	-0.3	0.4	-0.3	1.9	1.0	-0.2
Hair Pigment	0.0	0.4	1.7	0.4	-1.3	0.4	-0.1	-0.4	0.5
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.2	-0.4	-0.3	-0.1	0.0	0.2	-0.1
Allergy	0.0	0.1	0.2	0.3	-0.4	0.2	0.2	-0.3	-0.1

Hub : Genes

PSPC1

Models

Trait associations