TWAS hub - PTGDR

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.1262	0.0305	1.0e-08	0.099	0.079	0.111	0.112	0.119	1.4e-14	7.2e-12	2.5e-16	2.1e-16	2.3e-17
2	NTR	Blood	0.0191	0.0079	5.1e-03	0.019	0.003	0.013	0.008	0.014	8.1e-07	3.6e-02	3.7e-05	7.5e-04	1.3e-05
3	YFS	Blood	0.2540	0.0324	0.0e+00	0.246	0.269	0.282	0.283	0.271	1.0e-79	3.5e-88	7.6e-93	2.6e-93	7.0e-89
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.1645	0.0817	1.3e-04	0.049	0.021	0.006	NA	0.025	2.8e-06	1.9e-03	6.4e-02	NA	7.9e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0844	0.0411	3.5e-04	0.004	0.030	0.031	NA	0.018	1.0e-01	2.4e-04	1.7e-04	NA	3.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Tinnitus: Yes, but not now, but have in the past	3.1	3.4	9.0	1.7	2.1	3.0	0.5	0.4
Allergy or Eczema	2.9	7.6	16.4	-2.7	-4.0	-3.1	0.4	-2.1
Hayfever, allergic rhinitis or eczema	2.9	6.3	11.1	-3.0	-3.3	-2.5	0.5	-2.2
Breastfed as a baby	2.6	3.2	8.6	-1.9	-0.6	-1.2	2.9	-1.5
Illnesses of father: None of the above (group 1)	2.6	3.2	5.2	1.7	2.0	2.0	-2.3	-0.6
Hayfever/allergic rhinitis (self-reported)	2.5	3.4	6.5	-1.8	-2.6	-2.5	-0.1	-0.9
Exposure to tobacco smoke at home	2.5	2.8	8.4	-0.5	-2.2	-2.9	0.6	-0.3
Knee pain experienced in last month	2.5	3.9	8.6	-1.8	-2.9	-2.7	0.0	-0.4
Tinnitus: Yes, now most or all of the time	2.5	2.9	5.4	-2.3	-2.0	-2.3	-0.1	-0.2
Angina (self-reported)	2.3	3.0	5.4	-1.0	-2.3	-2.0	1.5	-1.5
Rheumatoid Arthritis	2.1	2.9	7.2	-1.6	-1.9	-1.1	2.7	0.4
Angina	2.0	2.6	4.8	-1.0	-2.2	-1.8	1.5	-1.3
Leg fat percentage (right)	2.0	7.2	12.7	-1.6	-2.9	-2.7	3.6	2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.3	3.5	-1.8	-1.7	-0.7	1.2	1.9
Number of self-reported non-cancer illnesses	2.0	3.4	5.2	-2.1	-2.3	-2.1	1.7	-0.0
Blood Eosinophil Count	1.9	15.0	31.7	-2.4	-5.6	-5.2	1.3	-2.9
Pack years adult smoking proportion	1.9	3.0	5.6	1.7	1.7	2.4	1.8	0.5
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	3.9	-0.5	-1.4	-1.1	2.0	1.9
Qualifications: nursing, teaching	1.9	2.9	6.7	-1.1	-1.7	-1.9	-0.5	-2.6
Medication: Gliclazide	1.9	2.2	4.5	-0.9	-2.1	-2.1	0.7	0.9
Allergy	1.8	4.0	7.4	2.4	2.7	1.6	-0.3	2.1
Prospective memory result	1.8	2.2	3.2	-1.6	1.6	1.6	-0.4	-1.8
Loud music exposure frequency	1.8	1.9	2.4	1.0	1.5	1.5	-1.4	-1.4
Health satisfaction	1.8	2.3	6.6	-2.6	-1.1	-0.7	0.7	-1.7
Long-standing illness, disability or infirmity	1.8	2.7	5.4	-1.6	-2.1	-2.3	0.8	-0.9
Illnesses of father: High blood pressure	1.8	2.3	4.3	-0.7	-1.8	-2.1	0.7	-1.7
Alzheimer’s Disease (in father)	1.7	1.9	2.7	-1.5	-1.6	-1.4	-0.1	-1.6
Alzheimer’s Disease (including proxy)	1.7	2.5	4.9	-1.5	-1.5	-1.2	1.3	-2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.6	16.8	0.4	1.0	0.9	-4.1	-3.0
Length of working week for main job	1.7	1.9	3.7	-1.3	0.9	0.8	-1.6	-1.9
Neuroticism (2016)	1.6	2.3	7.7	-2.8	-0.9	-1.6	-0.4	-0.7
BMI	1.6	9.1	14.7	-2.4	-3.8	-3.4	3.3	1.6
Shortness of breath walking on level ground	1.6	1.9	4.2	-2.0	-1.2	-0.8	1.8	0.2
Ever had bowel cancer screening	1.6	1.8	4.0	-1.4	-0.8	-0.9	2.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	4.7	-0.5	-2.1	-2.2	-0.4	0.2
Leg fat percentage (left)	1.6	5.7	9.7	-1.7	-2.7	-2.5	3.1	1.6
Pack years of smoking	1.6	2.3	3.9	1.5	1.4	2.0	1.7	0.7
Chronic bronchitis/emphysema (father)	1.5	1.7	2.5	0.8	1.4	1.6	1.1	1.5
Body fat percentage	1.5	6.1	16.1	-2.1	-1.7	-1.7	4.0	2.1
Leg fat mass (right)	1.5	5.7	10.6	-1.3	-2.6	-2.5	3.2	1.8
Irritability	1.5	2.6	6.5	-1.2	-0.5	0.2	-2.2	-2.5
Average weekly fortified wine intake	1.4	1.6	3.0	-0.8	-1.7	-1.4	1.0	1.2
Headache pain in last month	1.4	2.4	10.1	-3.2	0.2	0.2	1.3	0.2
Forced vital capacity (FVC), Best measure	1.4	5.0	15.3	0.8	1.0	0.9	-3.9	-2.7
Had other major operations	1.3	1.6	3.9	-1.3	2.0	1.5	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1)	1.3	4.5	11.0	0.8	1.6	1.5	-3.3	-2.5
Qualifications: A levels/AS levels or equivalent	1.3	2.9	4.8	0.0	2.1	1.4	-2.2	-1.7
Hypothyroidism/myxoedema (self-reported)	1.3	2.5	5.5	0.3	-2.3	-2.2	1.1	-0.9
Exposure to tobacco smoke outside home	1.3	1.7	3.8	1.7	0.8	0.5	1.0	1.9
Wheeze or whistling in the chest in last year	1.3	2.2	5.7	-1.0	-2.4	-1.6	1.1	-0.9
Family relationship satisfaction	1.3	1.6	2.9	-1.5	-1.4	-1.7	-0.8	-0.7
Arm fat percentage (left)	1.3	5.0	13.3	-1.7	-1.5	-1.5	3.7	2.1
Loneliness, isolation	1.3	1.8	6.9	-1.1	-0.5	-0.0	0.7	-2.6
Leg fat mass (left)	1.3	5.0	9.2	-1.3	-2.5	-2.4	3.0	1.4
HbA1C	1.2	1.3	2.9	0.6	1.1	1.7	0.4	1.4
Type 2 Diabetes (T2D) (2012)	1.2	1.3	4.3	-0.4	-0.4	-0.7	-2.1	-1.3
Trunk fat percentage	1.2	4.9	15.0	-2.1	-0.6	-0.6	3.9	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.5	0.7	1.1	1.9	-0.9	-1.4
Body mass index (BMI)	1.2	5.2	8.4	-0.7	-2.9	-2.5	2.9	1.7
Waist circumference	1.2	4.3	7.9	-1.6	-2.8	-2.6	2.1	0.3
Alcohol usually taken with meals	1.2	1.9	3.8	-1.9	-0.9	-0.8	1.0	-1.7
Arm fat percentage (right)	1.2	4.8	12.6	-1.4	-1.8	-1.7	3.5	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.9	5.4	0.3	1.9	2.3	-0.0	-0.4
Medication for pain relief, constipation, heartburn	1.2	2.1	3.6	1.9	1.9	1.2	-1.4	0.2
Smoking status: Previous	1.2	1.8	3.5	0.3	1.3	1.6	-1.0	1.9
Wears glasses or contact lenses	1.2	1.4	4.2	-1.4	-0.3	-0.2	0.8	2.0
Ever taken oral contraceptive pill	1.2	1.3	2.5	0.7	1.4	1.6	-0.9	-0.9
Frequency of depressed mood in last 2 weeks	1.1	1.6	3.4	0.3	1.2	1.6	-0.6	-1.9
Medication for hormone replacement therapy	1.1	1.3	2.9	-1.0	-1.4	-1.7	0.4	-0.6
Pulse rate	1.1	1.9	4.0	2.0	-1.8	-1.4	-0.1	0.7
Medication: Lansoprazole	1.1	1.3	4.8	-0.9	-0.3	-0.0	2.2	0.9
Impedance of arm (left)	1.1	5.1	12.5	-1.9	3.5	2.9	0.9	0.3
Diabetes diagnosed by doctor	1.1	1.8	2.9	-1.5	-1.6	-1.7	1.2	0.1
Depression (Nagel 2018)	1.0	1.6	4.0	0.1	0.6	1.8	-0.5	-2.0
Type 2 Diabetes (T2D) (2018)	1.0	1.9	3.0	-1.7	-1.5	-1.7	0.9	-0.6
Fed-up feelings	1.0	1.8	5.6	-1.5	0.0	0.4	-1.0	-2.4
Number of incorrect matches in round	1.0	1.6	6.2	-0.4	0.2	-0.1	-1.3	-2.5
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.1	0.6	1.4	2.0	-0.6	-0.7
Hair/balding pattern: Pattern 3	1.0	1.5	3.1	-1.8	1.1	1.1	1.4	-0.2
Lung cancer (father)	1.0	1.2	2.2	-1.2	-0.5	-0.1	-1.4	-1.5
Arm fat mass (right)	1.0	3.9	8.5	-1.0	-2.1	-1.9	2.9	1.4
Blood clot in the leg (DVT)	1.0	1.3	3.0	0.8	1.3	0.9	-1.7	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	4.2	-0.1	-2.0	-1.0	1.1	0.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	4.2	0.0	0.2	0.2	1.2	2.0
Migraine (self-reported)	1.0	1.3	4.2	-2.1	0.6	-0.1	0.6	-1.2
Whole body fat mass	1.0	4.2	11.0	-1.5	-1.6	-1.5	3.3	1.7
Pulse rate, automated reading	1.0	3.1	8.1	1.1	-2.9	-2.2	-0.5	-1.0
Suffer from ‘nerves’	1.0	1.5	4.0	1.6	0.1	0.2	-2.0	-1.1
Medication: Aspirin	1.0	1.3	2.5	-1.6	-1.5	-1.0	0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.1	-1.6	1.1	0.3	-1.6	-2.0
Arm fat mass (left)	1.0	4.1	10.1	-1.2	-1.9	-1.7	3.2	1.6
Hearing aid user	1.0	1.2	2.8	-0.9	-0.9	-1.0	-1.7	-0.6
Medication: Lisinopril	1.0	1.3	3.4	-0.8	1.5	1.8	-0.2	0.5
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	4.1	-2.0	0.1	0.5	1.0	1.0
Supplements: Calcium	1.0	1.1	3.0	-0.7	-1.7	-1.3	-0.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.1	1.0	-1.5	-0.7	0.9	0.8
Forced vital capacity (FVC)	0.9	3.6	10.2	0.9	1.1	0.9	-3.2	-2.2
Impedance of arm (right)	0.9	4.2	10.9	-1.1	3.3	2.9	1.0	-0.1
Depression (self-reported)	0.9	1.1	3.2	-0.5	1.8	1.3	0.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.7	-0.3	-1.6	-1.6	-0.2	-0.3
Number of full sisters	0.9	1.1	3.3	-1.8	-0.2	-1.2	0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.6	0.8	0.2	0.6	-1.9	-1.4
Medication: Aspirin	0.9	1.2	2.5	-1.6	-1.5	-1.1	0.1	-0.2
Eye problems/disorders: Glaucoma	0.9	1.1	3.0	-1.7	-0.7	-0.3	1.2	0.5
Pain experienced in last month	0.9	1.5	4.4	2.1	0.7	0.1	1.0	1.4
Alcohol drinker status: Previous	0.9	1.1	2.3	-0.7	-1.2	-1.5	0.7	0.7
Waist Hip Ratio (WHR)	0.8	3.4	6.6	1.3	-1.5	-1.1	-2.6	-2.3
Respiratory disease	0.8	1.7	3.2	-0.6	-1.8	-1.4	-0.5	-1.7
Number of treatments/medications taken	0.8	1.4	3.1	-1.6	-1.8	-0.9	0.6	-0.4
Systolic blood pressure, automated reading	0.8	2.2	3.6	1.1	1.7	1.4	1.1	1.9
Vitamin and mineral supplements	0.8	1.1	3.6	0.1	1.1	0.3	1.9	0.6
Medication: Metformin	0.8	1.2	1.8	-1.3	-0.8	-1.2	1.3	0.6
Severe depression (siblings)	0.8	0.9	1.9	0.3	1.4	1.0	-0.6	-0.9
Relative age voice broke	0.8	1.2	3.4	-1.2	0.3	0.3	-0.9	-1.8
Trunk fat mass	0.8	3.6	10.5	-1.7	-1.0	-1.0	3.2	1.6
Illnesses of siblings	0.8	1.1	3.9	-0.7	0.6	0.7	0.6	-2.0
Hip circumference	0.8	3.4	9.5	-1.1	-1.3	-1.3	3.1	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	-0.6	-1.1	-0.5	-0.8	-1.5
Medication: Cholesterol lowering	0.8	1.2	4.0	-2.0	-0.9	-0.7	0.0	-0.9
Medication: Paracetamol	0.8	1.3	2.8	-1.7	-0.8	-1.0	1.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	4.3	0.2	0.3	0.3	0.5	2.1
Overall health rating	0.8	1.7	2.3	-1.5	-1.4	-1.5	0.4	-1.4
Leg pain on walking	0.8	1.0	1.8	-1.3	-0.8	-1.0	-0.5	-1.1
Supplements: Vitamin C	0.8	0.9	1.4	0.7	-1.2	-1.1	-1.2	-0.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.3	-0.1	0.0	-0.3	1.2	1.8
Number of operations (self-reported)	0.8	1.2	3.4	-0.4	1.8	1.4	0.1	-0.4
Fractured/broken bones in last 5 years	0.8	1.0	2.0	1.2	-0.4	-0.5	-1.0	1.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.6	-0.4	0.6	0.6	1.2	-1.3
Body Mass Index (BMI) (2010)	0.7	1.0	2.3	-0.5	-1.3	-1.5	-0.7	0.6
Smoking Status	0.7	1.8	5.0	-1.1	1.0	0.9	-2.2	-0.9
Supplements: Zinc	0.7	0.8	1.5	0.5	-1.2	-1.2	0.6	0.6
Taking other prescription medications	0.7	1.1	1.9	-1.4	-1.2	-0.2	1.4	0.0
Past tobacco smoking	0.7	1.3	2.9	-0.1	-0.8	-1.4	0.9	-1.7
Had menopause	0.7	0.9	1.7	0.3	-1.3	-1.2	-0.2	1.2
Heart attack	0.7	0.9	2.7	-0.2	-1.3	-0.2	-0.2	-1.6
Medication: Ramipril	0.7	0.9	3.2	-0.4	-0.3	-1.0	-0.3	-1.8
Father’s age at death	0.7	1.0	1.9	-1.4	-1.1	-1.1	0.8	-0.0
Pulse wave peak to peak time	0.7	0.9	2.2	-0.2	1.5	1.0	-0.7	0.7
Medication: Ibuprofen	0.7	0.9	2.2	0.2	-1.0	-0.9	-0.6	-1.5
Medication: Omeprazole	0.7	0.8	2.0	-1.2	-0.1	0.4	0.4	1.4
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.7	-1.3	-0.5	-0.9	1.3	0.0
Average weekly red wine intake	0.7	1.0	2.4	-0.3	-1.5	-1.3	-0.1	-1.0
Friendships satisfaction	0.7	0.8	1.6	-0.2	-1.2	-1.1	-1.2	0.2
Commuting to job workplace: Walk	0.7	0.7	1.6	0.5	1.3	1.1	-0.8	0.2
Asthma (self-reported)	0.7	1.5	2.8	-1.3	-1.7	-1.2	0.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.7	-1.6	0.0	-0.2	0.5	1.4
Medication: Paracetamol	0.7	1.1	2.4	-1.5	-0.7	-1.1	1.1	-0.2
Ever smoked	0.7	1.2	2.4	0.4	0.4	1.0	-1.5	1.5
Age started oral contraceptive pill	0.7	0.8	2.9	0.0	-0.4	-0.6	0.9	1.7
Basal cell carcinoma (self-reported)	0.7	0.8	1.4	0.0	-0.9	-1.0	1.2	0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.8	0.4	1.0	0.6	-1.7	-0.5
Impedance of whole body	0.7	3.7	9.9	-1.3	3.1	2.6	0.3	0.2
Depressed Affect (Nagel 2018)	0.6	1.2	3.4	-1.3	-0.9	-0.3	-0.3	-1.9
Ovarian Cancer	0.6	0.8	2.1	1.3	-0.2	0.1	0.5	1.4
Lupus	0.6	1.0	2.6	0.2	-1.6	-1.4	-0.4	0.1
Systolic Blood Pressure	0.6	3.2	8.3	1.3	2.9	2.2	-0.8	0.7
Diabetes (father)	0.6	0.7	1.6	1.0	-1.3	-0.8	0.2	-0.7
Diabetes (mother)	0.6	0.7	2.0	-0.5	-0.1	-0.6	1.4	1.1
Hand grip strength (right)	0.6	1.5	6.3	0.7	-0.6	-0.3	-2.5	-0.5
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.6	-1.3	0.2	-0.2	-0.5	1.2
Qualifications: CSEs or equivalent	0.6	0.8	2.1	0.6	-1.4	-0.9	0.2	-0.9
Multivitamins +/- minerals	0.6	0.8	2.6	-0.5	-1.6	-0.5	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.1	-1.3	0.8	1.8	1.2	0.1
Mouth/teeth dental problems	0.6	0.9	2.7	0.1	1.6	1.1	0.9	-0.1
Neuroticism score	0.6	1.2	3.3	-1.4	-0.2	0.1	-0.9	-1.8
Asthma	0.6	1.2	1.8	-1.3	-1.3	-0.8	0.3	-1.3
Pulse wave Arterial Stiffness index	0.6	0.7	1.9	0.3	-1.4	-0.9	0.3	-0.9
Tense / ‘highly strung’	0.6	0.9	2.7	-1.6	0.1	0.3	0.0	-1.4
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	2.3	1.5	0.7	0.5	-1.1	-0.6
Comparative body size at age 10	0.6	1.8	3.2	-1.7	-1.4	-1.8	-0.7	-0.4
Neck or shoulder pain in last month	0.6	0.9	1.7	-0.6	0.9	0.8	-1.3	-1.1
Medication: Allopurinol	0.6	0.8	2.7	-0.8	-0.8	-0.5	0.2	-1.6
Mean time to correctly identify matches	0.6	1.1	2.6	-0.4	-0.5	-0.5	1.6	1.5
Mood swings	0.6	1.0	3.6	-0.2	0.3	0.8	-0.8	-1.9
Breast cancer (self-reported)	0.6	0.7	1.1	-0.6	-0.7	-1.0	0.7	1.1
Smoking status: Current	0.6	1.0	2.1	-0.8	-0.4	-0.5	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.0	0.3	-1.0	-1.2	-1.4	-1.3
Medication: Bendroflumethiazide	0.6	0.9	2.2	-0.7	-0.4	-1.5	-1.0	-0.7
Medication: Atorvastatin	0.6	0.8	1.9	-0.6	-1.4	-1.2	0.5	0.3
Alcohol drinker status: Never	0.6	0.7	2.3	0.4	0.5	0.6	0.6	-1.5
Myopia	0.6	0.8	1.4	1.2	1.1	0.4	0.6	-0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.2	0.1	-1.3	-0.2	-0.2	-1.5
Neuroticism (Nagel 2018)	0.5	1.1	2.3	-0.9	-1.2	-0.7	-0.6	-1.5
LDL Cholesterol	0.5	0.8	1.6	-0.5	-1.3	-1.2	-0.2	0.8
Ulcerative Colitis	0.5	0.7	2.6	0.2	-0.6	-0.6	-0.1	1.6
Blood White Count	0.5	3.5	8.0	-2.8	-1.8	-1.9	0.2	-1.6
Hand grip strength (left)	0.5	1.3	4.0	0.5	-0.4	-0.1	-2.0	-1.4
Hearing difficulty/problems: Yes	0.5	0.7	1.6	-0.8	-1.3	-0.6	-0.5	-0.8
Ever used hormone-replacement therapy (HRT)	0.5	0.7	3.0	-1.7	0.1	-0.0	0.5	-0.1
Medication: Co-codamol	0.5	0.6	1.3	0.6	-0.2	-0.6	1.0	1.1
Townsend deprivation index at recruitment	0.5	0.7	1.1	1.0	0.7	0.9	0.7	0.9
High blood pressure (mother)	0.5	0.7	1.4	-1.2	-0.2	-0.4	-1.2	-0.7
Qualifications: None of the above	0.5	1.0	2.6	-0.5	0.7	0.7	1.1	1.6
Alcohol intake versus 10 years previously	0.5	0.7	1.7	-0.8	0.8	1.3	0.8	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	1.5	0.3	0.7	-0.4	-1.0
Falls in the last year	0.5	0.6	1.2	1.1	0.3	0.7	0.9	-0.8
Birth weight of first child	0.5	0.9	3.4	-1.8	0.5	0.5	0.9	0.2
Birth weight	0.5	1.0	2.2	-1.2	-0.4	-0.0	-1.5	-1.2
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	-0.6	1.0	0.8	1.0	0.1
Comparative height size at age 10	0.5	2.9	6.6	-0.1	1.9	1.8	-2.6	-1.2
Chest pain or discomfort	0.5	0.7	1.0	1.0	-1.0	-0.3	-0.4	-1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-0.6	-0.6	-1.1	0.5	0.9
Miserableness	0.5	0.9	3.2	-1.0	0.0	0.3	-0.1	-1.8
Mother’s age at death	0.5	0.7	1.5	-1.2	0.9	0.6	-0.3	-0.9
Unable to work because of sickness or disability	0.5	0.7	1.8	-0.2	1.4	1.2	0.1	-0.3
Heart disease (siblings)	0.5	0.6	1.1	0.6	-0.8	-1.1	0.5	0.8
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	-0.4	-0.9	-1.2	1.5	0.6
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.8	0.6	-1.4	-1.7	0.6	0.2
Worry (Nagel 2018)	0.4	0.9	2.0	-0.0	-0.7	-0.3	-1.4	-1.4
Bipolar Disorder (2011)	0.4	0.4	1.6	-1.3	0.1	0.3	0.4	-0.1
Schizophrenia (2014)	0.4	0.9	2.4	-0.9	-0.4	-1.2	1.6	0.1
Triglycerides	0.4	0.6	0.8	-0.9	-0.8	-0.9	-0.4	-0.7
Lung FVC	0.4	2.2	6.8	1.3	0.8	0.8	-2.6	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.8	-0.0	0.5	0.1	-1.3	-0.5
Age when periods started (menarche)	0.4	1.0	3.3	0.4	-0.6	0.2	1.1	1.8
Stomach or abdominal pain in last month	0.4	0.4	1.7	-1.3	0.1	0.6	0.2	-0.5
Medication: Levothyroxine sodium	0.4	0.6	1.5	-0.2	-1.1	-0.6	1.2	-0.2
Impedance of leg (left)	0.4	1.9	4.1	-0.8	2.0	1.6	-1.2	-1.0
Nervous feelings	0.4	0.8	2.0	-0.7	-0.2	0.3	-1.4	-1.2
Diabetes (self-reported)	0.4	0.6	1.3	-0.1	-1.1	-1.1	0.8	0.3
Fluid intelligence score	0.4	0.9	2.1	-0.4	-1.2	-1.4	0.2	-0.8
Weight	0.4	2.1	4.2	-0.6	-1.7	-1.5	2.1	0.8
Worrier / anxious feelings	0.4	0.7	1.7	-0.4	-1.1	-0.2	-0.8	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.0	-0.4	-1.0	-0.8	-0.4	-1.0
Peak expiratory flow (PEF)	0.4	1.0	1.8	0.5	0.8	0.7	-1.2	-1.4
Glaucoma (self-reported)	0.4	0.5	1.4	-1.2	0.3	0.1	0.2	1.0
High blood pressure (siblings)	0.4	0.6	1.2	-0.1	-0.9	-0.9	-1.1	0.2
Number of full brothers	0.4	0.6	1.1	1.1	0.7	0.6	-0.8	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.9	0.9	-0.1	0.4	0.8	1.0
Age at first live birth	0.4	0.6	1.1	0.4	0.7	0.7	1.0	0.9
Medication: Seretide 50 evohaler	0.4	0.5	1.3	-1.1	-0.8	-0.5	0.4	0.1
Financial situation satisfaction	0.4	0.5	1.3	1.1	0.2	0.1	-0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	2.2	-1.5	-0.1	-0.0	0.3	0.1
Schizophrenia (2018)	0.3	0.7	2.0	-0.1	-0.4	-1.1	1.4	0.5
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.9	-0.0	-1.1	-1.4	0.3	-0.4
Prostate Cancer	0.3	0.4	1.3	0.6	0.2	0.1	-0.3	1.2
Age at First Birth	0.3	0.4	1.1	1.0	0.8	0.1	-0.1	0.7
Crohns Disease (2012)	0.3	0.5	1.8	-0.1	0.4	0.5	0.2	1.3
Blood Platelet Count	0.3	3.6	11.6	-3.4	-1.1	-2.0	0.4	-1.1
Hypothyroidism (self reported)	0.3	0.6	1.7	0.2	-0.7	-1.3	0.7	-0.5
Lung FEV1/FVC ratio	0.3	1.3	2.9	-1.1	0.5	0.2	-1.5	-1.7
Neuroticism	0.3	0.8	2.3	-1.2	-0.5	-0.3	-0.3	-1.5
Chronotype (morning person)	0.3	0.8	2.4	1.5	0.5	1.0	-0.5	0.0
Average weekly spirits intake	0.3	0.4	0.7	-0.8	-0.4	0.1	0.8	0.9
Current tobacco smoking	0.3	0.6	1.8	-0.3	-0.2	-0.4	-1.3	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.2	0.1	1.2	1.0	0.7
Serious illness, injury or assault to yourself	0.3	0.3	0.9	0.9	-0.7	-0.4	0.2	0.1
Medication: Atenolol	0.3	0.3	1.1	-0.5	0.2	0.5	1.0	0.1
Noisy workplace	0.3	0.4	1.3	-0.4	0.5	1.1	0.4	0.0
Mouth/teeth dental problems: Dentures	0.3	0.5	1.2	-1.1	-0.7	-0.6	-0.7	0.1
Pulse wave reflection index	0.3	0.4	1.1	-0.8	-0.2	0.3	-0.2	-1.1
Gout (self-reported)	0.3	0.5	1.3	-0.7	-0.2	-0.2	1.2	-0.6
Worry too long after embarrassment	0.3	0.6	2.1	-1.4	0.2	0.4	0.7	-0.0
Eye problems/disorders: None of the above	0.3	0.3	1.2	1.1	-0.5	-0.2	0.0	0.4
Heart disease (mother)	0.3	0.4	0.9	0.4	-0.9	-0.4	0.3	1.0
Illnesses of father: Heart disease	0.3	0.4	1.2	-0.8	0.1	-0.4	1.1	0.4
Illnesses of siblings: Diabetes	0.3	0.4	1.1	0.7	-0.4	-0.1	-1.1	0.5
Eye problems/disorders: Cataract	0.3	0.3	1.3	-0.4	0.0	-0.2	0.2	-1.1
Back pain experienced in last month	0.3	0.4	0.9	-0.9	-0.2	0.8	-0.3	-0.3
Average weekly champagne plus white wine intake	0.3	0.4	1.5	-1.2	0.2	-0.0	0.5	0.3
Arm fat-free mass (left)	0.3	1.7	4.0	0.8	-2.0	-1.9	0.1	-0.5
Average weekly beer plus cider intake	0.3	0.5	1.6	-0.8	-0.5	0.3	1.3	0.1
Risk taking	0.3	0.4	1.2	-1.1	-0.2	-0.2	-0.7	0.3
Cholesterol lowering medication	0.3	0.4	1.0	1.0	-0.8	-0.0	-0.2	-0.6
Arm predicted mass (left)	0.3	1.3	3.1	1.0	-1.7	-1.5	-0.2	-0.5
Bipolar Disorder (2018)	0.2	0.4	0.8	-0.6	-0.9	-0.6	0.5	0.3
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	-0.6	0.4	-0.1	-0.5	-0.5
Irritable Bowel Disease (IBD)	0.2	0.4	1.7	0.2	-0.3	0.3	0.4	1.3
Ulcerative Colitis (UC)	0.2	0.3	1.1	-0.1	-0.3	-0.2	0.4	1.0
Major Depression (MDD)	0.2	0.3	0.7	-0.8	0.2	0.5	0.5	0.4
Reaction Time	0.2	0.4	1.0	0.4	0.2	0.3	1.0	0.8
Breast Cancer	0.2	0.4	1.0	0.6	-0.6	-1.0	-0.2	0.3
Mean Putamen Volume	0.2	0.2	0.6	-0.0	-0.7	-0.6	-0.0	0.3
Fasting Glucose	0.2	0.2	0.6	0.3	-0.8	-0.2	-0.1	-0.7
Cardiovascular Disease	0.2	0.5	1.8	-1.3	-0.4	-0.5	0.5	-0.3
Sensitivity / hurt feelings	0.2	0.4	1.6	-1.3	0.1	-0.3	0.4	-0.0
Impedance of leg (right)	0.2	1.1	2.8	-0.4	1.7	1.5	-0.6	0.1
Maternal smoking around birth	0.2	0.3	1.4	1.2	0.1	0.5	0.3	0.0
Supplements: Glucosamine	0.2	0.3	0.5	0.4	-0.4	-0.4	0.7	0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.7	0.2	0.8	-0.0	-0.6
Financial difficulties in last 2 years	0.2	0.3	1.1	0.3	0.2	0.3	-1.1	0.0
Pain all over the body in last month	0.2	0.2	0.5	-0.3	-0.1	-0.3	-0.7	-0.7
Medication: Simvastatin	0.2	0.3	1.2	-1.1	-0.2	0.5	0.2	-0.3
Trunk fat-free mass	0.2	1.1	3.2	1.8	-0.9	-0.7	-1.0	-0.5
Time employed in main current job	0.2	0.3	1.1	1.1	-0.1	-0.4	0.3	-0.1
Happiness	0.2	0.2	0.5	0.1	-0.4	0.4	-0.5	-0.7
Trunk predicted mass	0.2	1.1	2.7	1.6	-1.0	-0.7	-1.0	-0.6
Standing height	0.2	2.5	4.3	0.4	2.1	1.6	-1.7	-1.6
Ever highly irritable/argumentative for 2 days	0.2	0.3	0.5	0.2	0.2	0.5	0.6	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.1	-0.7	-0.7	0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	1.7	1.3	0.4	0.4	-0.1	-0.2
Medication: Amlodipine	0.2	0.3	1.1	-0.1	-0.3	-0.7	-1.0	0.3
Arm fat-free mass (right)	0.2	0.8	1.9	0.7	-1.4	-1.3	0.0	-0.2
Number of children fathered	0.2	0.2	0.5	-0.3	0.4	0.7	0.2	0.4
Medication: Blood pressure	0.2	0.3	1.0	-1.0	-0.0	-0.0	-0.1	-0.7
Alcohol intake frequency.	0.2	0.5	2.2	-0.3	-0.4	-0.3	0.1	-1.5
Had major operations	0.2	0.2	0.4	-0.1	0.4	0.4	0.6	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.2	-0.6	-0.4	0.6	-0.6
Mineral and other dietary supplements	0.2	0.3	0.6	0.8	0.4	0.1	-0.5	-0.8
Osteoporosis (self-reported)	0.2	0.2	0.5	0.5	-0.0	-0.7	-0.6	0.2
Osteoarthritis (self-reported)	0.2	0.2	0.6	-0.3	0.5	-0.2	-0.8	0.4
Guilty feelings	0.2	0.3	0.9	-0.6	-0.3	0.3	1.0	-0.5
Commuting to job workplace: Public transport	0.2	0.3	0.9	-1.0	0.0	-0.2	-0.7	0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.8	-0.6	-0.4	-0.3	0.3
Diastolic blood pressure, automated reading	0.2	0.6	2.2	0.8	-0.3	-0.3	0.5	1.5
Ever depressed for a whole week	0.2	0.3	0.9	-0.4	-0.2	0.4	0.2	-1.0
Crohns Disease (2017)	0.1	0.3	0.6	-0.2	-0.5	0.5	0.5	0.8
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.3	-0.3	0.3	-0.2	0.5
Primary Biliary Cirrhosis	0.1	0.2	0.5	-0.7	0.2	0.3	0.4	0.2
Heel T-Score	0.1	0.8	1.7	-0.4	0.6	1.3	0.7	1.1
Height	0.1	2.1	3.7	-0.8	1.9	1.9	-0.5	-1.5
Tanning	0.1	1.3	3.4	-0.4	-1.4	-1.8	-1.1	-0.2
Relative age of first facial hair	0.1	0.1	0.3	-0.2	0.3	0.5	-0.2	-0.5
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.4	-0.1	-0.2	-0.2	-0.6
Leg fat-free mass (left)	0.1	0.3	0.7	0.4	-0.6	-0.5	0.9	0.0
High blood pressure	0.1	0.4	1.4	-1.2	0.7	-0.1	0.2	0.0
Leg predicted mass (left)	0.1	0.3	0.8	0.4	-0.6	-0.5	0.9	0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.4	-0.1	0.4	-0.6	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.3	0.1	0.4	0.2	0.4
Number of live births	0.1	0.2	0.5	-0.3	-0.0	-0.7	0.3	-0.4
Illnesses of mother	0.1	0.2	0.4	0.2	-0.4	-0.1	-0.5	-0.7
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	1.0	0.3	-0.3	-0.4	0.2
Qualifications: College or University degree	0.1	0.2	0.9	0.2	-0.2	-0.2	-1.0	-0.1
Emphysema/chronic bronchitis	0.1	0.2	0.3	-0.5	0.3	0.4	-0.1	-0.5
Arm predicted mass (right)	0.1	0.6	1.2	0.7	-1.1	-1.1	-0.1	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.2	0.4	-0.1	-0.5	-0.7	-0.4	-0.1
Hypertension (Self-reported)	0.1	0.2	0.8	-0.9	0.4	-0.2	0.1	0.0
Whole body fat-free mass	0.1	0.6	1.4	1.2	-1.0	-0.7	-0.1	-0.5
Whole body water mass	0.1	0.6	1.4	1.2	-1.0	-0.8	-0.1	-0.5
Medication: Blood pressure	0.1	0.1	0.4	-0.4	0.0	-0.0	-0.3	0.6
High cholesterol (Self-reported)	0.1	0.2	0.7	0.0	0.3	0.8	0.4	-0.0
Basal metabolic rate	0.1	0.5	1.0	0.7	-1.0	-0.8	0.3	-0.1
Commuting to job workplace: Cycle	0.1	0.1	0.1	0.3	0.3	-0.4	-0.0	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	1.0	1.0	-0.5	-0.0	-0.2	-0.2
HDL Cholesterol	0.0	0.1	0.3	0.6	-0.1	-0.0	0.0	0.1
Blood Red Count	0.0	0.3	0.7	-0.1	-0.1	0.3	0.8	0.7
Hair Pigment	0.0	0.9	1.6	1.3	-0.7	-0.5	-1.0	-0.9
Sitting height	0.0	0.2	0.5	0.7	0.6	0.3	-0.1	-0.1
Age at last live birth	0.0	0.0	0.1	-0.0	0.3	0.0	-0.1	-0.1
Leg fat-free mass (right)	0.0	0.2	0.4	0.3	-0.4	-0.4	0.4	-0.7
Medication for cholesterol	0.0	0.0	0.1	-0.0	0.3	0.3	-0.1	0.0
Leg predicted mass (right)	0.0	0.2	0.4	0.3	-0.5	-0.5	0.5	-0.7

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Trait associations