TWAS hub - PTPRM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.3610	0.1060	4.4e-03	0.008	NA	0.165	NA	0.101	1.8e-01	NA	1.3e-05	NA	6.6e-04
2	GTEx	Cells Transformed fibroblasts	0.1970	0.0610	3.7e-03	0.019	NA	0.015	NA	0.029	1.3e-02	NA	2.5e-02	NA	3.1e-03
3	NTR	Blood	0.0890	0.0177	3.4e-10	0.021	0.037	0.059	0.043	0.043	1.7e-07	3.7e-12	2.0e-18	1.1e-13	7.1e-14
4	YFS	Blood	0.1426	0.0216	0.0e+00	0.039	0.082	0.102	0.110	0.091	1.1e-12	1.3e-25	2.1e-31	3.9e-34	2.4e-28
5	TCGA	Brain Lower Grade Glioma	0.0634	0.0222	1.3e-03	0.053	0.029	0.018	NA	0.037	1.2e-06	2.5e-04	3.0e-03	NA	4.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Diabetes (father)	2.8	3.5	11.8	-1.4	0.0	-1.3	-1.4	3.4
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.3	7.7	-0.6	1.1	2.8	2.7	0.5
Tinnitus: Yes, now most or all of the time	2.8	3.3	11.0	0.8	0.4	0.9	2.0	3.3
Schizophrenia vs Biploar Disorder	2.5	3.3	6.2	2.5	-1.2	-1.5	-0.9	-2.4
Illnesses of father: None of the above (group 1)	2.5	3.1	8.0	1.7	0.4	1.8	1.1	-2.8
Diabetes diagnosed by doctor	2.3	3.8	8.4	-0.7	-2.1	-2.9	-1.0	2.1
Medication: Gliclazide	2.2	2.4	6.2	0.5	-2.2	-0.8	0.7	2.5
Wears glasses or contact lenses	2.1	2.4	7.4	2.7	-1.1	0.5	1.5	-0.8
Noisy workplace	2.0	2.5	6.3	2.5	0.1	1.6	1.8	-0.7
Blood clot in the leg (DVT)	2.0	2.6	7.9	0.8	0.7	2.0	2.8	0.1
Mean Putamen Volume	1.9	2.2	5.4	-0.3	-0.5	-2.3	-2.2	-0.7
Type 2 Diabetes (T2D) (2018)	1.9	3.5	6.9	-1.3	-1.2	-2.4	-1.3	2.6
Comparative body size at age 10	1.9	5.3	17.6	0.6	0.5	1.7	2.3	4.2
Emphysema/chronic bronchitis	1.9	2.1	7.2	-1.5	-2.7	-0.9	0.1	0.3
Eye problems/disorders: Cataract	1.9	2.2	3.3	1.4	-1.4	1.6	1.8	-1.0
Asthma (self-reported)	1.9	3.9	15.1	-3.9	0.9	0.7	-1.0	-1.4
Medication: Aspirin	1.9	2.5	9.6	-0.4	-3.1	-0.2	1.0	1.2
Medication for hormone replacement therapy	1.8	2.0	3.7	-0.9	-1.4	0.6	1.9	1.7
Shortness of breath walking on level ground	1.8	2.2	5.4	-0.8	-0.9	-2.3	-1.9	0.2
Number of self-reported non-cancer illnesses	1.8	3.2	10.0	-3.2	-1.3	-0.9	0.5	1.8
Body Mass Index (BMI) (2010)	1.7	2.4	5.2	-0.4	-1.0	1.6	2.3	1.8
Fasting Glucose	1.7	2.0	3.5	0.2	1.2	1.6	1.6	-1.9
Medication: Metformin	1.7	2.4	6.0	-0.7	-0.6	-2.4	-1.8	1.5
Nervous feelings	1.7	3.2	6.3	-1.0	-2.0	-2.5	-2.0	-0.7
Heart attack	1.7	2.2	5.8	-1.0	-2.4	0.6	0.7	1.8
Chronic bronchitis/emphysema (mother)	1.7	1.9	4.0	-0.9	1.1	1.7	2.0	-1.0
Medication: Aspirin	1.7	2.2	7.0	-0.5	-2.6	-0.1	1.3	1.4
Illnesses of father: Heart disease	1.7	2.4	6.4	0.9	-0.2	-2.5	-1.4	1.6
Osteoarthritis (self-reported)	1.7	2.2	6.8	-0.5	-1.6	0.7	1.0	2.6
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	6.7	0.7	0.4	2.0	2.6	0.2
Primary Biliary Cirrhosis	1.6	2.3	6.5	0.2	-0.8	-2.1	-2.5	0.1
Respiratory disease	1.6	3.5	13.9	-3.7	0.8	0.5	-0.7	-1.5
Diabetes (self-reported)	1.6	2.5	7.3	-0.4	-1.7	-2.7	-1.0	1.1
Hair/balding pattern: Pattern 4	1.6	3.8	9.7	-1.4	0.0	-2.4	-1.4	3.1
Medication: Amlodipine	1.6	2.2	4.1	-1.8	-1.0	-2.0	-1.5	0.7
Rheumatoid Arthritis	1.5	2.1	5.7	0.7	-0.7	-2.4	-1.8	0.4
BMI	1.5	8.8	30.7	-1.4	-2.2	0.7	2.4	5.5
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.1	-1.3	-2.0	1.0	1.0	-0.8
Asthma	1.5	3.0	11.3	-3.4	0.8	0.7	-0.9	-1.4
Medication: Cholesterol lowering	1.5	2.4	7.0	-0.1	-1.8	-1.2	-0.1	2.6
Lung FEV1/FVC ratio	1.4	7.0	26.4	1.7	0.1	0.8	2.2	5.1
Medication for cholesterol	1.4	2.2	4.2	2.0	1.6	-0.1	-1.3	-1.6
Commuting to job workplace: Cycle	1.4	1.7	7.0	-2.6	0.5	0.2	-0.8	0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	5.0	-0.9	-2.2	0.5	0.5	1.7
Lupus	1.3	2.0	5.4	0.9	0.3	1.7	2.3	0.9
Schizophrenia (2014)	1.3	2.9	8.5	1.9	-0.2	-2.9	-1.5	-0.1
Number of treatments/medications taken	1.3	2.3	5.8	-2.2	-2.4	-0.2	0.9	0.1
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.6	1.2	1.6	1.2	1.3	-0.7
Body mass index (BMI)	1.3	5.7	20.7	-0.3	-1.3	1.3	2.0	4.5
Average weekly champagne plus white wine intake	1.3	1.8	3.5	-1.3	0.8	-1.4	-1.9	-1.2
Alzheimer’s Disease (in mother)	1.2	1.4	3.4	-0.2	-0.6	1.9	1.3	-1.2
HDL Cholesterol	1.2	2.1	3.4	-0.9	-1.0	-1.5	-1.7	-1.9
Smoking Status	1.2	2.9	5.5	1.8	0.5	1.5	2.4	-1.8
Supplements: Glucosamine	1.2	1.6	5.3	0.7	1.1	-2.3	-0.9	-0.1
Allergy	1.2	2.9	12.8	3.6	1.0	-0.5	0.5	-0.3
Time employed in main current job	1.2	1.4	5.5	-0.3	-0.6	-2.3	-0.9	0.2
Medication: Paracetamol	1.2	1.9	5.0	-2.2	-1.0	-0.5	-0.7	-1.7
Number of children fathered	1.2	1.3	3.3	0.1	-0.7	1.8	1.6	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.3	-0.7	2.1	1.1	0.9	0.2
Average weekly beer plus cider intake	1.2	1.7	4.7	0.1	0.5	2.2	1.9	-0.3
Major Depression (MDD)	1.1	1.3	5.0	-1.0	-0.7	-0.1	-0.3	2.2
Reaction Time	1.1	2.1	8.3	-1.0	-0.7	-0.1	-0.8	2.9
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	11.3	0.7	-0.2	0.7	0.6	3.4
Hayfever, allergic rhinitis or eczema	1.1	2.5	9.8	-3.1	-1.3	0.5	0.1	0.9
Father’s age at death	1.1	1.5	4.9	0.1	-2.2	-1.3	0.2	0.9
Glaucoma (self-reported)	1.1	1.3	3.6	-0.7	1.5	-0.0	-0.4	1.9
Mean time to correctly identify matches	1.1	2.1	8.4	-0.5	-1.4	-0.3	-0.2	2.9
Alcohol intake frequency.	1.1	2.6	5.5	-1.8	-1.4	0.2	1.6	2.3
Long-standing illness, disability or infirmity	1.1	1.7	3.9	-2.0	-0.0	-1.6	-0.1	1.5
Eye problems/disorders: Glaucoma	1.1	1.4	5.3	0.3	2.3	0.6	-0.3	0.9
Medication: Paracetamol	1.1	1.8	4.0	-1.7	-1.2	-0.4	-0.5	-2.0
Medication: Lisinopril	1.1	1.4	2.3	1.5	0.3	-1.5	-1.1	-1.0
Basal cell carcinoma (self-reported)	1.1	1.3	5.7	-0.2	-2.4	-0.2	0.0	-0.7
Alcohol drinker status: Previous	1.1	1.3	3.0	-1.6	0.3	0.6	0.5	1.7
Number of incorrect matches in round	1.0	1.7	5.9	0.8	-1.0	-0.6	-0.7	-2.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	10.8	-0.6	-0.0	0.2	0.2	3.3
Medication: Simvastatin	1.0	1.5	4.8	-0.8	-0.6	0.2	1.2	2.2
Arm fat percentage (right)	1.0	3.9	15.4	0.5	-1.1	0.9	1.3	3.9
Mouth/teeth dental problems: Dentures	1.0	1.8	4.1	2.0	-0.9	-0.3	1.9	0.4
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	4.5	-0.6	0.8	-0.7	-0.8	-2.1
Number of full sisters	1.0	1.2	2.2	-0.6	-1.5	1.1	1.1	-1.0
Arm fat percentage (left)	1.0	4.1	15.5	0.6	-1.1	1.1	1.4	3.9
Guilty feelings	1.0	1.5	3.3	-0.9	0.0	-1.6	-1.8	-0.8
Unable to work because of sickness or disability	1.0	1.3	3.3	-1.3	-0.4	0.8	0.7	-1.8
Cholesterol lowering medication	1.0	1.5	3.4	-1.8	-1.0	-1.0	0.2	1.4
Ovarian Cancer	0.9	1.2	5.5	-2.4	-0.0	0.4	-0.6	-0.3
Heel T-Score	0.9	7.1	33.8	-1.0	-0.3	-0.0	0.9	5.8
Medication: Co-codamol	0.9	1.0	2.7	-0.8	0.9	1.6	0.6	0.8
Number of live births	0.9	1.3	4.2	-0.4	0.4	1.1	2.0	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	1.9	0.2	1.2	1.4	1.0	0.9
Prospective memory result	0.9	1.1	2.4	1.0	-1.1	-1.5	-0.7	-0.5
Arm fat mass (right)	0.9	3.7	13.6	-0.1	-1.0	1.2	1.6	3.7
Exposure to tobacco smoke at home	0.9	1.1	2.0	-1.4	-0.7	-1.1	-1.1	0.7
Breastfed as a baby	0.9	1.1	2.8	-0.0	-1.7	-1.4	0.0	0.9
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.3	0.5	-0.1	-1.8	-1.1	1.4
Gout (self-reported)	0.9	1.3	2.8	1.0	-1.7	-1.1	0.2	1.1
Medication: Blood pressure	0.9	1.5	2.9	0.1	-1.2	-1.7	-0.9	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	2.5	0.8	-0.9	-1.1	-0.2	1.6
Had major operations	0.9	1.1	2.9	-0.0	-0.6	1.4	1.7	0.4
Commuting to job workplace: Car/motor vehicle	0.9	1.1	1.9	1.3	1.4	-0.1	-0.1	-1.3
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	3.1	-0.3	1.0	-0.8	-1.8	-1.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	3.0	-0.4	-1.0	-1.7	-0.8	-0.8
Loneliness, isolation	0.9	1.2	4.2	-2.1	-0.7	-0.8	-0.2	0.9
Qualifications: nursing, teaching	0.9	1.4	6.2	0.2	0.8	-0.2	-0.2	2.5
Breast cancer (self-reported)	0.9	1.1	2.8	0.9	0.9	0.7	1.7	-0.8
Ever smoked	0.9	1.6	4.3	0.3	0.5	1.4	2.1	-1.1
Heart disease (siblings)	0.9	1.1	3.4	1.3	0.5	-0.3	-0.2	1.8
Leg fat mass (left)	0.9	3.4	10.8	0.1	-1.2	1.5	1.6	3.3
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	-1.1	1.4	0.3	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.8	1.1	3.1	0.4	-0.6	-1.3	-1.8	-0.1
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.1	1.8	-0.8	-0.1	0.9	-0.0
Severe depression (siblings)	0.8	0.9	2.5	-0.2	-0.0	1.5	1.6	-0.1
Pack years adult smoking proportion	0.8	1.2	2.2	0.0	-1.2	1.1	1.5	1.2
Impedance of leg (right)	0.8	3.7	14.1	0.6	1.2	-0.2	-1.6	-3.8
Current tobacco smoking	0.8	1.3	3.7	1.4	-0.0	0.2	0.7	-1.9
Medication: Atenolol	0.8	1.0	2.3	-1.1	-0.2	-0.9	-1.5	0.6
Impedance of leg (left)	0.8	4.0	13.1	1.0	1.1	-0.7	-2.0	-3.6
Waist circumference	0.8	2.9	9.0	-0.9	-1.7	0.6	1.3	3.0
Past tobacco smoking	0.8	1.5	3.3	-0.1	-0.7	-1.7	-1.8	0.9
Financial difficulties in last 2 years	0.8	1.1	2.8	0.6	-1.5	0.4	1.7	0.4
Happiness	0.8	0.9	1.7	-1.3	1.1	0.5	-1.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	3.3	-1.8	0.4	-0.9	-1.2	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.3	-0.3	0.8	1.8	0.9	-0.3
Loud music exposure frequency	0.8	0.9	3.1	-1.8	1.0	-0.0	-0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.2	-1.1	1.8	0.8	0.4	-0.6
Wheeze or whistling in the chest in last year	0.8	1.5	5.0	-2.2	-0.8	0.4	1.2	0.3
Angina (self-reported)	0.8	1.1	2.0	1.0	-1.1	1.4	1.1	-0.2
Overall health rating	0.8	1.7	4.1	0.1	-2.0	-0.8	1.4	1.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.7	-1.1	0.6	-1.0	-1.3	0.2
Mineral and other dietary supplements	0.8	1.1	2.2	-0.5	-0.9	1.2	0.8	1.5
Arm fat mass (left)	0.8	3.5	12.7	0.1	-0.9	1.3	1.5	3.6
Medication: Atorvastatin	0.8	1.0	2.7	-1.3	-1.6	-0.3	-0.7	-0.4
Leg fat percentage (left)	0.8	2.8	9.4	0.2	-1.2	1.1	1.4	3.1
Ever depressed for a whole week	0.8	1.0	2.6	-1.6	-0.6	-1.0	-0.8	-0.7
Myopia	0.8	1.2	2.2	-1.4	-1.0	-1.5	-0.4	0.8
Pack years of smoking	0.8	1.2	1.9	0.5	-1.4	0.9	1.4	1.0
Schizophrenia (2018)	0.7	1.4	4.5	1.0	-0.0	-2.1	-1.0	-0.7
LDL Cholesterol	0.7	1.1	2.6	0.5	-1.6	-0.7	-1.3	0.5
Allergy or Eczema	0.7	1.8	7.0	-2.6	-0.9	0.1	-0.1	1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.3	-1.5	-0.7	-1.0	-0.8	0.2
Supplements: Zinc	0.7	0.8	2.2	-0.9	0.1	0.7	0.5	-1.5
Hair/balding pattern: Pattern 2	0.7	0.9	2.3	-1.5	0.1	1.1	0.7	-0.4
Had menopause	0.7	0.9	2.6	0.2	0.9	0.2	0.9	-1.6
Forced vital capacity (FVC)	0.7	2.6	9.5	0.9	1.2	1.1	0.4	-3.1
Pain all over the body in last month	0.7	0.7	2.3	0.5	1.5	0.9	0.5	-0.4
Impedance of arm (right)	0.7	3.1	7.4	0.9	0.7	-1.7	-2.7	-1.9
Qualifications: A levels/AS levels or equivalent	0.7	1.5	3.8	0.6	-2.0	-1.8	-0.4	-0.2
Depression (self-reported)	0.7	0.9	2.6	-0.5	1.6	0.0	-0.9	-0.7
Tense / ‘highly strung’	0.7	1.2	3.0	-0.3	0.8	-0.8	-1.7	-1.2
Headache pain in last month	0.7	1.2	4.5	-0.4	2.1	-0.7	-0.4	-0.9
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.8	-0.1	1.3	1.2	0.1	-1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.2	-1.8	0.8	0.9	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.7	2.5	8.1	0.7	0.7	1.9	0.2	-2.8
Body fat percentage	0.7	2.8	10.0	0.7	-1.2	0.9	1.2	3.2
Leg fat percentage (right)	0.7	2.4	8.0	0.0	-1.0	1.2	1.3	2.8
Exposure to tobacco smoke outside home	0.7	0.9	2.9	0.1	1.2	0.4	1.7	0.4
Medication for pain relief, constipation, heartburn	0.7	1.2	2.9	1.4	1.7	0.2	-0.7	0.9
Migraine (self-reported)	0.7	0.8	2.3	-1.5	0.3	-1.1	-0.5	0.5
Medication: Allopurinol	0.7	1.0	2.0	1.4	-1.4	-0.8	0.4	0.3
Medication: Omeprazole	0.7	0.8	1.6	-0.5	-1.2	1.2	0.8	0.6
Heart disease (mother)	0.7	0.8	2.2	1.5	0.6	-0.4	0.3	1.1
Whole body fat mass	0.7	2.8	9.4	0.3	-1.1	1.1	1.3	3.1
Leg fat mass (right)	0.7	2.9	9.1	0.1	-1.1	1.4	1.5	3.0
Supplements: Vitamin C	0.7	0.8	1.5	1.1	0.6	-0.8	-0.7	-1.2
Hearing aid user	0.7	0.8	1.7	-0.6	0.4	0.5	1.3	1.3
Risk taking	0.7	1.1	4.5	0.3	-0.4	0.3	2.1	0.8
Impedance of whole body	0.7	3.5	9.2	0.9	1.1	-1.0	-2.3	-3.0
Ulcerative Colitis (UC)	0.6	1.1	3.1	-1.2	1.1	0.0	-1.8	-0.1
Age at First Birth	0.6	0.9	3.3	0.3	0.8	-0.4	-1.8	-0.4
Neuroticism (2016)	0.6	0.9	3.7	0.9	-0.1	-1.9	-0.3	0.0
Relative age of first facial hair	0.6	1.1	3.2	0.6	1.3	0.3	0.6	1.8
Angina	0.6	0.8	1.4	0.8	-1.0	1.2	0.7	-0.3
Trunk fat percentage	0.6	2.3	8.7	0.7	-1.1	0.7	0.8	3.0
Average weekly fortified wine intake	0.6	0.7	1.0	-1.0	-0.3	1.0	0.9	-0.8
Maternal smoking around birth	0.6	0.9	2.6	1.6	-0.5	0.0	1.0	-0.6
Qualifications: CSEs or equivalent	0.6	0.8	2.1	-0.8	-0.2	1.5	0.9	0.5
Serious illness, injury or assault to yourself	0.6	0.8	2.4	-0.4	-0.7	0.0	1.6	0.9
Trunk fat mass	0.6	2.5	8.4	0.5	-1.1	1.2	1.2	2.9
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	-1.2	-0.7	-0.5	-0.8	-0.8
Medication: Ramipril	0.6	0.8	2.6	-0.6	-1.6	-0.1	0.1	0.9
Illnesses of siblings	0.6	0.8	2.0	-1.4	-1.2	-0.5	-0.3	-0.6
Hip circumference	0.6	2.7	8.4	-1.1	-0.1	1.3	1.4	2.9
Pulse rate	0.6	1.1	2.9	-0.8	-0.7	-1.0	0.4	1.7
Impedance of arm (left)	0.6	2.6	5.2	0.9	0.8	-1.2	-2.3	-2.3
Birth weight of first child	0.6	1.0	2.9	-0.7	0.2	-1.0	-1.7	-0.9
Pulse wave reflection index	0.6	0.7	1.3	-0.5	-0.2	-0.9	-1.0	-1.1
Worry too long after embarrassment	0.6	1.0	2.6	0.2	0.6	-1.3	-1.6	0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.5	0.8	-0.3	1.0	1.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.2	-1.2	1.1	-0.2	-1.5	-1.2
Friendships satisfaction	0.6	0.7	2.1	1.0	1.5	-0.4	-0.0	0.6
Financial situation satisfaction	0.6	0.8	3.0	1.7	0.5	0.3	0.1	-0.7
Supplements: Calcium	0.6	0.6	1.6	0.4	-0.8	-0.9	0.0	-1.2
Intelligence (Savage-Jansen 2018)	0.5	1.7	3.5	0.8	0.4	-1.5	-1.3	1.9
Verbal and Numeric Reasoning (VNR)	0.5	1.3	2.7	0.8	0.2	-1.6	-1.6	0.7
Prostate Cancer	0.5	0.7	1.7	-0.3	0.8	-0.1	-1.3	1.0
Chronotype (morning person)	0.5	1.2	3.3	-0.6	-1.3	-0.2	-0.6	1.8
Sensitivity / hurt feelings	0.5	0.9	2.2	-0.1	-0.4	-1.5	-1.3	0.7
Ever had hysterectomy (womb removed)	0.5	0.5	2.4	0.2	-0.5	-0.0	0.2	1.5
Townsend deprivation index at recruitment	0.5	0.7	2.3	0.7	-0.4	0.6	1.5	-0.1
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.1	0.8	-0.8	0.1	1.1	0.8
Mouth/teeth dental problems	0.5	0.7	2.4	-0.7	0.5	-0.0	-1.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.0	-1.4	0.4	0.8	0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	2.6	1.2	1.6	1.3	0.9	-1.2
Lung cancer (father)	0.5	0.6	1.7	0.0	-1.3	-0.1	-0.3	-1.0
Illnesses of mother	0.5	0.7	1.9	-0.7	-1.4	-0.7	-0.4	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	4.1	1.3	0.8	2.0	0.4	-0.9
Number of full brothers	0.5	0.6	1.8	-0.7	-1.3	0.5	0.6	0.2
Age at first live birth	0.5	0.9	2.2	1.0	1.5	-0.4	-1.1	0.4
Health satisfaction	0.5	0.7	1.5	-0.7	1.1	-0.3	0.1	-1.2
Qualifications: College or University degree	0.5	1.6	3.7	1.9	0.2	-0.4	-1.5	-1.2
Neck or shoulder pain in last month	0.5	0.7	1.4	-0.5	1.2	-1.1	-0.7	0.5
Medication: Seretide 50 evohaler	0.5	0.6	2.1	-1.4	-0.6	-0.2	-0.7	-0.3
Comparative height size at age 10	0.5	2.7	7.6	-1.1	1.3	1.7	0.6	-2.8
Illnesses of siblings: Diabetes	0.5	0.6	2.4	-0.2	0.3	-0.6	-0.1	1.5
Smoking status: Previous	0.5	0.8	1.5	0.8	0.5	1.2	1.2	-0.5
Ever had bowel cancer screening	0.5	0.6	1.6	0.5	-1.3	-0.9	-0.5	0.2
Back pain experienced in last month	0.5	0.7	1.4	0.3	-1.1	-1.2	-0.7	-0.8
Mother’s age at death	0.5	0.7	2.3	1.5	0.2	0.2	1.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.3	-0.2	-1.5	-0.9	0.2	0.3
Alcohol drinker status: Never	0.5	0.6	1.2	-0.7	0.3	0.9	0.8	1.1
Number of operations (self-reported)	0.5	0.7	1.9	-0.3	-1.4	0.2	0.7	1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.8	0.3	-1.3	-0.8	-0.2	0.3
Medication: Omeprazole (e.g. Zanprol)	0.5	0.7	1.4	0.6	-0.8	1.2	0.8	0.4
Bipolar Disorder (2018)	0.4	0.7	1.6	-1.2	-0.3	-0.6	0.0	1.1
Bipolar Disorder or Schizophrenia	0.4	0.9	3.9	-0.0	-0.2	-2.0	-0.7	0.2
Worry (Nagel 2018)	0.4	0.9	2.3	-1.1	-0.3	-0.5	-1.5	-0.9
Alzheimer’s Disease (including proxy)	0.4	0.6	2.1	-0.7	0.0	1.5	-0.3	-0.7
Irritable Bowel Disease (IBD)	0.4	1.0	1.6	-1.2	1.2	-0.4	-1.3	0.4
HbA1C	0.4	0.4	1.3	1.2	0.2	-0.1	0.8	0.2
Height	0.4	6.9	24.4	1.6	1.1	-1.0	-2.3	-4.9
Waist Hip Ratio (WHR)	0.4	1.8	3.3	1.7	-1.8	-0.1	0.5	-1.5
Cardiovascular Disease	0.4	1.4	5.0	-2.2	1.0	-0.9	-0.4	0.4
Hypothyroidism (self reported)	0.4	0.9	3.1	0.2	-1.1	0.3	0.2	1.8
Vitamin and mineral supplements	0.4	0.6	1.7	0.6	-1.3	0.7	0.4	0.3
Taking other prescription medications	0.4	0.5	2.1	-0.3	-1.4	-0.6	0.3	0.3
Multivitamins +/- minerals	0.4	0.5	1.4	-0.7	1.2	-0.1	0.7	-0.1
Chronic bronchitis/emphysema (father)	0.4	0.5	2.0	-0.4	0.1	-0.0	-0.5	-1.4
Hearing difficulty/problems with background noise	0.4	0.6	1.2	-0.1	-1.1	-0.7	0.9	0.7
Had other major operations	0.4	0.5	1.8	-1.4	0.0	0.0	-0.5	0.6
Qualifications: None of the above	0.4	0.8	2.4	-0.8	-1.5	-1.0	-0.1	0.1
Fluid intelligence score	0.4	0.9	2.5	-0.0	-0.6	-1.1	-0.7	1.6
Weight	0.4	2.0	6.4	-0.5	-0.7	1.2	1.1	2.5
Alcohol intake versus 10 years previously	0.4	0.6	1.6	0.1	-0.1	-0.2	1.2	1.2
Falls in the last year	0.4	0.5	1.0	-0.5	-1.0	0.1	-0.4	-1.0
Hair/balding pattern: Pattern 3	0.4	0.7	1.7	1.3	0.5	0.9	0.7	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	-1.3	0.8	-0.1	-0.1	-0.7
Standing height	0.4	3.8	15.1	-0.1	1.4	0.5	-1.4	-3.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.4	-0.8	-0.1	-1.2	-0.4	-0.4
Pulse wave peak to peak time	0.4	0.4	1.2	0.6	-1.1	0.7	0.2	-0.2
Medication: Ibuprofen	0.4	0.4	1.7	-1.3	0.1	0.6	0.3	-0.1
Average weekly red wine intake	0.4	0.6	1.7	0.0	-0.3	-0.5	-1.1	-1.3
Smoking status: Current	0.4	0.7	2.0	1.0	0.2	0.2	0.7	-1.4
Commuting to job workplace: Public transport	0.4	0.5	1.0	0.6	-0.9	-0.0	1.0	0.0
High cholesterol (Self-reported)	0.4	0.8	2.1	-0.7	-0.6	-0.8	0.4	1.5
Illnesses of father: High blood pressure	0.4	0.5	0.7	0.7	0.8	0.4	0.6	0.8
Fractured/broken bones in last 5 years	0.4	0.5	1.3	0.2	-1.2	-0.2	-0.5	-1.0
Age started oral contraceptive pill	0.4	0.5	1.4	0.9	-0.2	-0.3	0.2	-1.2
Neuroticism (Nagel 2018)	0.3	0.7	1.3	-0.6	0.5	-1.1	-1.1	-0.7
Alzheimer’s Disease (in father)	0.3	0.3	0.9	-0.7	-0.2	0.4	-0.9	0.4
Crohns Disease (2017)	0.3	0.6	0.9	-0.7	0.5	-0.9	-0.9	0.6
Bipolar Disorder (2011)	0.3	0.3	1.6	-0.1	-0.0	-0.2	-0.1	1.3
Triglycerides	0.3	0.5	1.9	-0.1	-0.4	-0.4	-0.2	1.4
Ulcerative Colitis	0.3	0.5	1.1	-1.1	0.7	0.3	-0.5	0.6
Systolic Blood Pressure	0.3	1.6	4.1	-2.0	1.9	0.0	0.3	0.5
Hearing difficulty/problems: Yes	0.3	0.5	1.9	1.4	0.1	-0.5	0.4	-0.1
Leg fat-free mass (left)	0.3	1.4	3.3	-0.7	-0.1	1.4	1.2	1.8
Relative age voice broke	0.3	0.4	1.6	0.2	1.2	-0.4	-0.0	0.6
Age when periods started (menarche)	0.3	0.8	1.5	1.1	0.9	0.7	0.2	-1.2
Stomach or abdominal pain in last month	0.3	0.4	0.9	-0.1	-0.4	-0.9	0.8	0.5
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.5	-1.1	0.3	0.6	-0.5
Sitting height	0.3	2.2	6.3	-0.6	1.0	-0.4	-1.8	-2.5
Leg predicted mass (left)	0.3	1.4	3.5	-0.7	-0.0	1.3	1.1	1.9
Alcohol usually taken with meals	0.3	0.4	1.0	-1.0	0.4	0.1	-1.0	-0.2
Worrier / anxious feelings	0.3	0.6	1.0	-1.0	-0.4	-0.4	-0.9	1.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.3	0.2	-1.1	-1.2	-0.2	0.2
Pulse wave Arterial Stiffness index	0.3	0.4	1.3	-0.5	1.1	-0.6	-0.0	0.3
Peak expiratory flow (PEF)	0.3	0.6	1.8	1.1	1.3	0.0	0.1	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	0.7	-1.2	0.7	0.4	0.2
High blood pressure (siblings)	0.3	0.4	1.6	1.3	0.2	0.5	0.3	-0.4
Arm predicted mass (right)	0.3	1.6	4.3	-0.0	-0.2	2.1	1.8	0.5
Pulse rate, automated reading	0.3	0.9	2.9	-0.2	-0.7	-0.5	1.0	1.7
Chest pain or discomfort	0.3	0.4	0.9	-0.5	-0.4	0.3	0.9	-0.9
Age at last live birth	0.3	0.4	1.5	-0.5	1.2	0.1	0.5	-0.4
Family relationship satisfaction	0.3	0.3	1.1	1.1	0.7	-0.1	-0.2	0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.0	-0.3	0.1	-0.7	-1.0	0.1
Osteoporosis (self-reported)	0.3	0.4	1.3	1.1	-0.3	-0.7	0.0	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	1.2	-0.3	1.1	0.3	0.4
Ever taken oral contraceptive pill	0.3	0.4	1.5	-0.1	-0.2	0.4	-0.4	-1.2
Diastolic blood pressure, automated reading	0.3	1.0	4.1	-0.9	2.0	0.4	-0.5	0.1
Pain experienced in last month	0.3	0.5	1.0	-1.0	-0.7	0.6	-0.8	0.1
Depression (Nagel 2018)	0.2	0.3	1.4	0.0	-1.2	-0.5	0.3	-0.1
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.6	-0.3	-0.1	0.5	-0.4
Crohns Disease (2012)	0.2	0.4	1.5	-0.2	0.2	-1.2	-0.5	0.0
Blood White Count	0.2	1.3	4.8	-0.3	-0.9	-2.2	-1.0	0.1
Lung FVC	0.2	1.3	2.7	1.5	-0.8	0.3	0.7	-1.6
Diabetes (mother)	0.2	0.2	0.4	-0.2	0.4	-0.6	-0.6	-0.4
Fed-up feelings	0.2	0.3	0.9	0.7	-0.2	-0.9	-0.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.9	-0.5	-0.2	-0.0	1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.8	0.2	0.3	-0.5	-0.9	0.2
Neuroticism score	0.2	0.5	1.1	-0.7	0.2	-0.9	-1.0	0.1
Medication: Lansoprazole	0.2	0.2	0.7	-0.2	-0.8	-0.2	-0.3	-0.0
Trunk predicted mass	0.2	0.9	3.0	-0.4	-0.1	1.7	1.2	0.2
Birth weight	0.2	0.5	1.6	-1.3	-0.7	-0.5	-0.4	-0.0
Arm fat-free mass (right)	0.2	1.1	3.2	-0.2	-0.2	1.8	1.4	0.5
Suffer from ‘nerves’	0.2	0.3	0.5	-0.7	-0.5	-0.7	-0.3	-0.3
Hypertension (Self-reported)	0.2	0.5	1.5	-0.7	-0.5	-1.2	-0.1	0.3
Whole body fat-free mass	0.2	1.0	2.7	-0.4	0.1	1.7	1.2	0.9
Leg fat-free mass (right)	0.2	1.0	3.2	-0.5	0.2	1.0	0.8	1.8
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.1	0.1	-1.0	-0.3	0.4	0.4
Whole body water mass	0.2	1.0	2.7	-0.3	-0.0	1.6	1.3	0.9
Leg predicted mass (right)	0.2	1.1	3.3	-0.5	0.2	1.1	0.9	1.8
Miserableness	0.2	0.4	1.0	0.3	0.6	-0.2	0.6	1.0
Medication: Blood pressure	0.2	0.4	1.5	-0.5	-1.2	0.2	0.4	0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.8	-0.0	0.7	0.2	-0.4	-0.9
Medication: Bendroflumethiazide	0.2	0.2	0.7	-0.0	0.0	-0.5	-0.8	0.5
Basal metabolic rate	0.2	1.2	2.4	-0.5	-0.0	1.5	1.2	1.4
Arm fat-free mass (left)	0.2	0.8	1.6	-0.2	-0.4	1.3	1.2	1.0
Irritability	0.2	0.3	0.8	0.9	0.3	-0.7	-0.6	0.2
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.7	0.5	0.8	0.7	-0.5	-0.7
Arm predicted mass (left)	0.2	1.0	2.4	-0.2	-0.1	1.5	1.3	1.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.6	-0.2	0.1	-0.4	0.3	0.8
Breast Cancer	0.1	0.3	0.8	-0.3	0.9	-0.2	0.1	0.6
Blood Eosinophil Count	0.1	0.8	1.5	-1.0	1.2	0.0	-0.9	0.9
Blood Platelet Count	0.1	1.1	2.0	-1.2	-0.5	-1.4	-1.0	-0.7
Blood Red Count	0.1	1.1	3.1	-0.2	1.8	0.9	1.3	0.1
Neuroticism	0.1	0.2	0.3	-0.3	0.5	-0.2	-0.6	-0.2
Tanning	0.1	1.5	2.3	1.4	-1.4	-1.1	-1.5	0.3
Hand grip strength (left)	0.1	0.4	0.9	0.9	0.9	0.2	0.2	0.5
Average weekly spirits intake	0.1	0.1	0.1	0.2	-0.1	0.3	0.3	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.6	-0.4	-0.4	-0.8	0.1	0.3
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.7	0.2	-0.0	0.6	0.6
Hand grip strength (right)	0.1	0.2	0.5	0.6	0.4	0.7	0.4	-0.0
High blood pressure	0.1	0.4	1.0	-0.4	-0.9	-1.0	0.1	0.2
High blood pressure (mother)	0.1	0.1	0.3	-0.6	-0.1	0.4	0.4	0.2
Trunk fat-free mass	0.1	0.9	2.8	-0.4	0.1	1.7	1.1	0.3
Length of working week for main job	0.1	0.1	0.3	-0.6	0.3	-0.3	-0.3	-0.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.0	-0.3	-0.3	-0.4	-0.2
Leg pain on walking	0.1	0.1	0.4	-0.6	0.1	0.0	0.2	-0.3
Knee pain experienced in last month	0.1	0.2	0.8	0.3	-0.9	0.3	0.4	-0.2
Mood swings	0.1	0.2	0.5	-0.7	0.2	-0.4	-0.4	0.6
Commuting to job workplace: Walk	0.1	0.1	0.3	0.2	-0.2	-0.5	0.2	0.3
Hair Pigment	0.0	0.1	0.2	-0.1	0.2	0.3	0.2	-0.5

Hub : Genes

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Trait associations