Hub : Genes

PTPRN

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0510	0.0230	0.0033	0.009	0.016	0.011	0.016	0.013	2.3e-02	0.00440	0.01500	0.0037	0.00810
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0538	0.0335	0.0018	0.041	0.034	0.020	NA	0.035	2.1e-05	0.00009	0.00220	NA	0.00007
3	TCGA	Lung Squamous Cell Carcinoma	0.0769	0.0393	0.0011	0.000	0.027	0.028	NA	0.004	3.7e-01	0.00042	0.00033	NA	0.11000

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.7	1.0	1.0	1.0	-0.2
Bipolar Disorder or Schizophrenia	1.0	2.3	3.8	1.9	1.7	-0.5
Depressed Affect (Nagel 2018)	6.1	12.9	23.0	4.8	0.6	-3.9
Depression (Nagel 2018)	3.0	4.5	8.2	2.9	0.2	-2.3
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.4	0.6	-0.2
Neuroticism (Nagel 2018)	3.2	7.5	12.2	3.5	0.7	-3.1
Schizophrenia (2018)	0.8	1.6	2.6	1.6	1.4	-0.4
Schizophrenia vs Biploar Disorder	1.2	1.6	2.3	-1.0	1.2	1.5
Worry (Nagel 2018)	0.2	0.5	1.4	0.3	0.2	-1.2
Alzheimer’s Disease (in mother)	0.9	1.1	1.8	-1.1	-1.3	0.4
Alzheimer’s Disease (in father)	0.6	0.7	2.0	-0.2	-0.0	-1.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.7	-1.3	-0.5	-0.3
Crohns Disease (2017)	0.1	0.2	0.4	0.6	0.5	0.1
Irritable Bowel Disease (IBD)	0.2	0.6	0.8	0.9	-0.9	-0.4
Ulcerative Colitis (UC)	0.9	1.7	2.4	1.1	-1.6	-1.2
Major Depression (MDD)	2.4	2.9	6.7	2.6	1.1	-1.0
Reaction Time	0.7	1.4	2.3	1.1	1.5	0.8
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.7	0.1	-0.2
Breast Cancer	1.2	2.9	4.6	1.4	-2.1	-1.5
Ovarian Cancer	0.4	0.6	1.7	1.3	-0.3	0.0
Prostate Cancer	0.1	0.1	0.1	-0.3	-0.4	0.1
Age at First Birth	0.1	0.1	0.2	-0.5	0.1	-0.2
Bipolar Disorder (2011)	1.9	1.8	2.6	0.8	-1.6	-1.5
Body Mass Index (BMI) (2010)	1.0	1.4	2.8	1.7	-0.9	-0.9
Coronary Artery Disease (CAD)	0.4	0.5	1.3	-0.4	-1.1	-0.1
Crohns Disease (2012)	0.2	0.4	0.5	0.5	0.7	0.7
Mean Putamen Volume	0.4	0.4	0.8	-0.4	0.6	0.9
Fasting Glucose	1.0	1.1	2.3	1.5	-0.3	-1.0
HbA1C	0.7	0.8	1.0	-0.6	1.0	-1.0
HDL Cholesterol	0.5	0.8	1.6	-0.9	1.2	0.0
LDL Cholesterol	0.2	0.3	0.6	0.6	-0.8	-0.2
Lupus	0.3	0.4	0.8	0.4	0.4	-0.9
Neuroticism (2016)	0.5	0.7	1.4	1.2	-0.5	-0.7
Primary Biliary Cirrhosis	0.8	1.1	1.5	0.9	1.2	-1.0
Rheumatoid Arthritis	2.4	3.3	8.3	2.9	-1.2	-0.6
Schizophrenia (2014)	0.7	1.5	2.3	1.1	1.5	-1.0
Triglycerides	0.4	0.6	1.2	0.2	-1.1	0.8
Type 2 Diabetes (T2D) (2012)	0.1	0.2	0.2	0.4	-0.5	-0.4
Ulcerative Colitis	0.8	1.2	2.2	-0.0	-1.5	-1.1
Blood Eosinophil Count	0.2	1.4	2.5	0.7	-1.6	-1.0
Blood Platelet Count	0.4	4.3	12.0	1.0	-3.5	-0.2
Blood Red Count	0.4	4.2	10.4	-0.9	-3.2	-1.1
Blood White Count	0.5	3.8	6.5	-0.9	-2.5	-2.1
Heel T-Score	0.4	3.1	6.7	2.6	-0.8	-1.4
BMI	1.7	9.6	18.2	3.0	-4.3	-1.3
Height	6.0	116.1	262.4	-16.2	4.3	8.2
Waist Hip Ratio (WHR)	0.8	3.7	6.1	-2.2	-0.1	2.5
Systolic Blood Pressure	0.1	0.7	2.1	1.4	-0.0	0.2
Smoking Status	0.5	1.2	2.3	1.5	0.1	-1.2
Allergy or Eczema	0.5	1.3	3.4	-1.8	0.5	0.5
Cardiovascular Disease	1.4	4.5	10.0	3.2	-1.2	-1.4
Hypothyroidism (self reported)	0.6	1.4	2.7	-1.6	0.5	1.1
Respiratory disease	0.1	0.2	0.3	-0.3	-0.4	-0.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.6	-1.3	-1.1	-0.4
Lung FEV1/FVC ratio	0.7	3.7	10.2	3.2	0.9	-0.0
Lung FVC	0.4	2.0	3.4	1.9	-0.9	-1.3
Neuroticism	1.7	4.2	9.6	3.1	-0.1	-1.7
Chronotype (morning person)	0.0	0.1	0.1	0.2	0.4	0.0
Hair Pigment	0.1	2.0	2.9	-1.7	-1.2	-1.4
Tanning	0.2	2.4	4.2	1.3	-1.1	-2.0
Hand grip strength (left)	1.2	3.2	7.0	-2.6	-1.6	0.5
Number of treatments/medications taken	0.5	0.9	1.7	0.8	-1.3	-0.6
Average weekly spirits intake	1.0	1.3	3.5	0.3	-1.9	-0.5
Sensitivity / hurt feelings	2.2	3.8	7.0	2.6	-0.5	-2.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	3.6	1.9	0.8	-1.6
Hearing difficulty/problems: Yes	0.7	1.1	2.0	-1.4	1.1	0.1
Relative age of first facial hair	1.0	2.0	3.0	-1.0	1.4	1.7
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.3	-1.1	0.5	1.0
Ever used hormone-replacement therapy (HRT)	1.4	1.8	2.6	1.6	0.9	-1.5
Ever had hysterectomy (womb removed)	0.8	1.0	2.1	1.4	-0.4	-0.8
Systolic blood pressure, automated reading	0.2	0.7	1.5	1.2	-0.1	0.8
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.6	1.3	-0.6	-1.2
Angina	0.8	1.0	1.9	0.3	-1.4	-1.1
Medication for hormone replacement therapy	4.1	4.5	13.3	0.3	3.6	0.5
Vitamin and mineral supplements	1.1	1.5	2.9	1.0	1.7	0.8
Supplements: Zinc	0.6	0.6	0.9	-0.8	-1.0	0.5
Medication: Co-codamol	0.4	0.5	0.7	-0.6	-0.8	0.6
Medication: Metformin	2.1	2.9	4.2	-2.1	-2.0	0.8
Diabetes (father)	0.2	0.3	0.8	-0.3	-0.1	0.9
Diabetes (mother)	0.6	0.8	1.9	-1.4	0.3	-0.6
Severe depression (siblings)	0.9	1.0	2.9	-1.7	-0.3	-0.2
Pack years adult smoking proportion	1.3	2.0	3.2	1.8	-1.5	-0.7
Impedance of leg (right)	1.2	5.8	9.7	-1.2	3.1	2.5
Leg fat-free mass (left)	1.0	5.2	10.6	-3.3	-2.1	0.8
Trunk fat percentage	0.6	2.5	4.6	-1.6	-2.1	0.6
Hand grip strength (right)	1.8	4.9	12.4	-3.5	-0.5	1.4
Townsend deprivation index at recruitment	1.0	1.5	2.9	1.7	-0.6	-1.1
Current tobacco smoking	3.6	5.8	10.4	3.2	-1.0	-2.5
Average weekly fortified wine intake	3.8	4.5	6.4	-2.0	1.8	2.5
Maternal smoking around birth	0.5	0.7	1.2	-0.0	0.9	1.1
Fed-up feelings	4.2	7.6	17.3	4.2	-0.1	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	4.4	1.6	-0.9	-2.1
Relative age voice broke	1.5	2.3	3.2	-0.9	1.8	1.7
Taking other prescription medications	0.3	0.4	0.9	-0.5	0.1	1.0
Age when periods started (menarche)	2.1	5.1	7.9	-2.6	0.8	2.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.4	-1.2	-0.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.0	0.3	0.5
Tinnitus: Yes, but not now, but have in the past	2.4	2.5	3.8	1.9	-0.1	-1.9
Qualifications: CSEs or equivalent	2.7	3.6	8.8	3.0	-1.0	-1.1
Serious illness, injury or assault to yourself	0.1	0.1	0.4	0.0	-0.0	0.6
High blood pressure	1.7	4.7	10.4	3.2	-1.2	-1.5
Hayfever, allergic rhinitis or eczema	0.5	1.0	2.2	-1.5	0.7	0.5
Multivitamins +/- minerals	3.7	4.8	8.3	-2.1	-2.9	-1.2
Stomach or abdominal pain in last month	0.9	1.1	2.2	1.0	-1.5	-0.2
Supplements: Glucosamine	0.2	0.2	0.3	0.0	-0.6	-0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.8	-1.4	0.8	0.2
Medication: Atenolol	0.9	1.1	3.2	1.8	0.1	-0.0
Medication: Levothyroxine sodium	0.7	1.3	3.5	-1.9	0.5	0.2
Sitting height	2.6	18.6	44.0	-6.6	1.1	3.3
Chronic bronchitis/emphysema (father)	1.2	1.4	2.6	-0.1	-1.6	-1.3
High blood pressure (mother)	0.6	0.8	1.5	1.2	0.9	0.2
Body mass index (BMI)	1.7	7.3	15.0	2.0	-3.9	-1.7
Impedance of leg (left)	1.4	6.9	11.1	-1.8	3.3	2.5
Leg predicted mass (left)	1.0	5.3	10.8	-3.3	-2.1	0.8
Trunk fat mass	1.1	4.8	7.1	-2.6	-2.7	0.8
Waist circumference	0.8	3.0	8.2	-0.9	-2.9	-0.0
Number of incorrect matches in round	1.5	2.5	6.5	0.2	2.5	1.0
Past tobacco smoking	0.1	0.2	0.4	0.4	-0.6	-0.4
Alcohol usually taken with meals	3.2	5.1	11.0	-2.0	0.6	3.3
Nervous feelings	0.2	0.4	0.8	0.5	-0.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.8	0.7	-0.9	-0.5
Hearing difficulty/problems with background noise	1.8	2.8	8.3	-0.4	2.9	-0.2
Hair/balding pattern: Pattern 2	0.8	1.0	2.0	1.4	0.8	0.5
Had menopause	0.4	0.5	1.3	-0.2	-0.2	-1.1
Had other major operations	2.0	2.5	5.0	2.2	-0.5	-1.5
Forced vital capacity (FVC)	1.0	4.0	5.6	-2.4	1.8	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	-0.7	1.1	0.5
Ever unenthusiastic/disinterested for a whole week	2.3	2.9	5.3	0.3	2.3	1.8
Qualifications: None of the above	0.2	0.5	0.8	0.8	-0.2	-0.9
Financial difficulties in last 2 years	1.1	1.5	2.4	1.5	0.5	-1.4
Mouth/teeth dental problems	0.4	0.6	0.8	-0.9	0.9	-0.4
Heart attack	0.2	0.3	0.5	-0.5	-0.0	0.7
Allergy	0.1	0.1	0.3	0.6	-0.0	-0.3
Pain all over the body in last month	2.3	2.4	3.1	1.2	-1.6	-1.8
Diabetes (self-reported)	2.3	3.6	8.6	0.6	-2.9	-1.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.3	-1.2	0.3	1.8
Medication: Ramipril	0.7	0.9	2.1	0.4	-0.7	-1.4
Medication: Simvastatin	0.6	1.0	1.6	1.3	-1.1	-0.2
Fluid intelligence score	0.3	0.7	1.6	-1.3	0.7	-0.0
Illnesses of siblings	1.0	1.3	2.1	1.3	-1.4	-0.5
Neuroticism score	2.0	4.2	9.2	3.0	0.8	-1.6
Weight	1.1	5.2	8.1	-2.8	-2.6	0.8
Impedance of arm (right)	1.9	9.0	12.7	-2.6	3.6	2.7
Arm fat percentage (right)	0.8	3.1	8.4	0.6	-2.9	-0.6
Trunk fat-free mass	1.3	7.5	17.6	-4.2	-1.6	1.6
Hip circumference	0.7	3.1	7.4	-1.3	-2.7	-0.2
Time employed in main current job	0.3	0.4	0.6	-0.7	0.3	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	0.9	0.6	-0.9	-0.3
Father’s age at death	1.0	1.4	2.1	-1.4	-0.1	1.4
Worrier / anxious feelings	0.2	0.3	0.6	-0.4	0.7	-0.4
Frequency of tiredness / lethargy in last 2 weeks	2.5	4.1	6.2	2.5	-0.3	-2.4
Falls in the last year	1.1	1.4	2.9	1.7	-0.9	-0.8
Hair/balding pattern: Pattern 3	0.4	0.6	1.5	1.2	-0.0	-0.6
Number of live births	0.5	0.7	0.9	0.6	-1.0	-0.9
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	2.9	-1.5	1.7	1.4
Pulse rate	1.0	1.7	2.6	1.3	-1.0	-1.6
Happiness	1.7	2.0	6.0	0.2	-0.1	-2.5
Noisy workplace	0.2	0.3	0.9	0.1	0.9	0.0
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	-0.3	0.1	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.2	0.8	-0.4	-1.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.2	-0.4	-0.5	0.4
Asthma	0.1	0.2	0.7	0.0	-0.8	-0.0
Medication: Ibuprofen (e.g. Nurofen)	1.9	2.5	7.2	-0.1	2.7	0.4
Medication: Cholesterol lowering	1.5	2.4	4.0	0.7	-1.7	-2.0
Depression (self-reported)	1.1	1.4	4.0	0.3	2.0	0.3
Medication: Lansoprazole	0.2	0.2	0.4	0.4	-0.6	-0.2
Prospective memory result	0.3	0.4	1.1	0.1	-1.0	-0.4
Lung cancer (father)	0.3	0.3	0.5	-0.6	0.7	-0.2
Illnesses of mother	0.3	0.4	0.8	-0.9	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	0.9	-0.6	0.9	0.8
Pulse wave Arterial Stiffness index	0.8	0.9	1.7	0.2	-1.3	-1.0
Impedance of arm (left)	2.4	11.1	13.2	-3.3	3.6	3.0
Arm fat mass (right)	0.9	3.7	10.8	-0.6	-3.3	-0.2
Trunk predicted mass	1.3	7.2	16.7	-4.1	-1.6	1.6
Standing height	5.0	49.9	114.5	-10.7	2.1	5.5
Length of working week for main job	0.1	0.1	0.2	0.1	0.5	0.3
Exposure to tobacco smoke at home	0.4	0.5	1.0	1.0	-0.5	-0.3
Breastfed as a baby	1.0	1.3	3.3	-0.6	0.3	1.8
Tense / ‘highly strung’	0.4	0.6	0.9	-0.9	0.7	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	3.0	0.8	1.7	-0.6
Hair/balding pattern: Pattern 4	0.7	1.7	4.3	-0.2	-0.8	-2.1
Birth weight of first child	0.4	0.7	1.5	0.2	1.2	0.8
Peak expiratory flow (PEF)	0.4	0.9	1.7	-1.3	-0.4	0.9
Pulse wave reflection index	1.1	1.4	2.9	1.1	-0.3	-1.7
Ever highly irritable/argumentative for 2 days	0.0	0.0	0.0	0.2	-0.2	-0.0
Loud music exposure frequency	1.0	1.1	1.9	1.4	-0.8	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	-0.5	-1.3	0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.1	0.1	0.3	0.1	0.3
Blood clot in the leg (DVT)	2.1	2.7	4.5	1.7	-2.1	-0.8
Medication: Paracetamol	1.0	1.7	3.2	1.2	0.5	-1.8
Headache pain in last month	2.4	4.0	8.2	2.9	0.5	-1.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	3.5	-0.8	1.7	1.9
Glaucoma (self-reported)	0.1	0.1	0.3	-0.5	-0.2	-0.2
Gout (self-reported)	0.1	0.2	0.4	0.6	0.1	0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-1.0	0.3	0.2
Medication: Amlodipine	1.7	2.3	3.2	1.8	-1.3	-1.4
Medication: Ventolin 100micrograms inhaler	0.0	0.0	0.1	-0.0	0.2	-0.3
Birth weight	0.3	0.6	1.7	0.1	-1.3	-0.3
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.1	-0.2	0.4	1.4
High blood pressure (siblings)	0.4	0.6	1.2	-0.5	1.1	0.6
Forced vital capacity (FVC), Best measure	0.3	1.3	2.3	-1.5	0.8	0.9
Body fat percentage	0.6	2.2	6.1	-0.7	-2.5	0.1
Leg fat percentage (right)	0.8	2.9	7.1	1.1	-2.7	-0.6
Arm fat-free mass (right)	1.0	5.2	10.6	-3.2	-2.0	0.8
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.4	0.2	-0.4
Comparative body size at age 10	0.3	0.9	2.4	-0.2	-1.6	-0.5
Number of full brothers	0.3	0.4	1.0	0.1	1.0	-0.4
Worry too long after embarrassment	1.3	2.3	5.1	2.3	-0.7	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	-0.6	0.4	0.8
Wheeze or whistling in the chest in last year	0.3	0.6	1.3	0.3	-1.2	-0.5
Number of children fathered	0.5	0.5	1.4	-1.2	0.4	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.4	0.1	0.3	0.6
Age at first live birth	1.0	1.7	2.5	-1.6	0.6	1.5
Pulse wave peak to peak time	1.5	1.7	2.5	-1.0	1.6	1.3
Health satisfaction	2.8	3.6	6.1	1.8	-1.2	-2.5
Shortness of breath walking on level ground	1.4	1.7	3.0	-0.8	-1.7	-1.2
Qualifications: College or University degree	0.6	1.9	2.5	-1.5	1.6	1.0
Eye problems/disorders: None of the above	2.5	2.9	5.5	2.3	-0.8	-1.6
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.3	-0.1	-0.5	0.5
Emphysema/chronic bronchitis	1.7	1.9	3.5	1.9	0.2	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.3	1.7	-1.2	-0.9	1.3
Neck or shoulder pain in last month	2.2	3.1	6.4	2.5	1.4	-1.1
Medication: Blood pressure	1.4	2.5	3.3	1.1	-1.7	-1.8
Angina (self-reported)	1.0	1.3	2.1	0.6	-1.5	-1.2
Migraine (self-reported)	0.4	0.4	0.6	0.5	-0.8	-0.7
Medication: Ibuprofen	2.7	3.2	9.1	0.1	3.0	0.8
Medication: Allopurinol	0.2	0.2	0.5	0.0	0.4	0.7
Medication: Omeprazole	0.6	0.7	1.9	1.4	-0.2	0.4
Medication: Seretide 50 evohaler	0.3	0.3	0.5	0.7	0.7	0.3
Mean time to correctly identify matches	0.5	1.0	2.4	0.5	1.6	0.7
Heart disease (mother)	0.9	1.1	1.7	-0.9	-1.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	0.5	-1.3	-0.3
Whole body fat mass	1.0	4.2	8.9	-1.9	-3.0	0.3
Leg fat mass (right)	1.0	3.7	10.6	-0.5	-3.2	-0.5
Arm predicted mass (right)	1.1	5.8	11.6	-3.4	-2.1	1.1
Pulse rate, automated reading	1.6	5.1	8.4	2.9	-0.0	-2.6
Alcohol intake frequency.	3.8	8.9	13.3	2.0	-3.6	-3.0
Comparative height size at age 10	2.9	16.2	41.0	-6.4	-0.6	2.7
Number of full sisters	1.3	1.5	2.5	0.8	-1.2	-1.6
Suffer from ‘nerves’	0.4	0.6	1.0	1.0	0.2	-0.9
Overall health rating	0.3	0.6	1.4	1.2	-0.3	-0.5
Chest pain or discomfort	2.6	3.8	8.3	-0.2	-2.9	-1.7
Had major operations	0.1	0.1	0.2	0.4	-0.4	0.1
Age at last live birth	1.2	1.8	2.7	-1.4	0.8	1.6
Family relationship satisfaction	0.3	0.4	0.6	-0.8	0.6	0.5
Leg pain on walking	1.5	1.9	3.4	-1.8	-1.3	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.2	6.5	2.5	0.3	0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	0.8	0.9	-0.9	-0.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.5	-1.2	-1.0	0.3
Medication: Aspirin	0.8	1.1	2.0	1.0	-1.4	-0.2
Supplements: Vitamin C	0.0	0.0	0.1	-0.1	0.3	0.1
Knee pain experienced in last month	1.2	1.8	2.5	-1.6	1.6	0.6
Hypertension (Self-reported)	1.5	4.1	9.3	3.0	-1.3	-1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.6	-1.2	-1.6	0.2
Illnesses of father: Heart disease	0.8	1.1	3.0	-0.6	-1.7	-0.0
Illnesses of siblings: Diabetes	0.3	0.4	0.8	0.9	0.6	-0.2
Smoking status: Previous	1.4	2.2	3.6	-1.9	1.2	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	6.8	-2.6	1.7	2.2
Whole body fat-free mass	1.2	6.9	15.6	-4.0	-1.9	1.2
Leg fat-free mass (right)	1.1	6.0	13.6	-3.7	-1.9	0.8
Arm fat percentage (left)	0.8	3.3	9.6	0.3	-3.1	-0.5
Average weekly red wine intake	3.9	5.7	13.1	-1.6	1.2	3.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.3	-0.5	0.4
Mood swings	3.0	5.3	9.0	3.0	1.8	-1.9
Loneliness, isolation	5.7	7.9	13.2	3.6	-0.7	-3.1
Long-standing illness, disability or infirmity	0.0	0.0	0.1	-0.2	0.3	-0.0
Ever had bowel cancer screening	1.6	1.9	4.9	-2.2	0.8	-0.5
Diabetes diagnosed by doctor	1.7	2.8	7.0	-0.4	-2.6	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	5.3	2.3	-0.2	-0.2
Friendships satisfaction	0.1	0.2	0.4	-0.2	0.6	0.3
Qualifications: nursing, teaching	1.0	1.5	3.7	-0.4	0.7	1.9
Commuting to job workplace: Walk	0.6	0.6	1.6	-0.4	-1.3	-0.1
Eye problems/disorders: Cataract	0.8	0.9	1.9	-1.4	-0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	1.3	-0.8	-0.8
Medication for cholesterol	1.0	1.5	4.1	-2.0	-0.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.1	4.5	0.9	2.1	-2.0
Back pain experienced in last month	0.2	0.3	0.8	-0.0	-0.3	-0.9
Mineral and other dietary supplements	0.2	0.3	0.6	0.1	0.8	-0.5
Breast cancer (self-reported)	0.0	0.1	0.1	-0.3	-0.0	-0.3
Asthma (self-reported)	0.2	0.4	0.9	0.4	-1.0	-0.2
Osteoporosis (self-reported)	0.3	0.4	1.0	0.4	1.0	-0.1
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.7	0.9	0.5
Medication: Aspirin	1.0	1.3	2.4	1.2	-1.6	-0.5
Medication: Gliclazide	3.1	3.5	7.1	-1.7	-2.7	-0.7
Illnesses of father: None of the above (group 1)	1.0	1.2	2.5	0.1	1.6	1.1
Smoking status: Current	4.8	7.6	12.8	3.6	-1.2	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	4.5	2.1	-0.7	-0.4
Whole body water mass	1.1	6.4	14.1	-3.8	-1.9	1.2
Leg predicted mass (right)	1.1	5.8	13.2	-3.6	-1.9	0.8
Arm fat mass (left)	0.9	3.6	10.4	-0.7	-3.2	-0.3
Number of self-reported non-cancer illnesses	0.6	1.0	2.3	1.5	0.3	-0.8
Average weekly champagne plus white wine intake	1.2	1.7	3.3	-1.8	0.7	1.1
Miserableness	2.6	4.5	7.7	2.8	1.4	-1.9
Guilty feelings	2.1	3.2	9.3	3.1	-0.2	-0.6
Wears glasses or contact lenses	0.3	0.3	0.5	0.7	-0.1	-0.7
Ever taken oral contraceptive pill	0.5	0.5	0.9	0.3	-0.8	-1.0
Hearing aid user	0.1	0.1	0.2	-0.1	-0.5	0.1
Mother’s age at death	1.9	2.4	6.5	-2.6	-0.4	-0.6
Financial situation satisfaction	2.8	3.5	4.8	1.7	-1.6	-2.2
Tinnitus: Yes, now most or all of the time	1.0	1.1	1.3	-1.1	-1.1	0.9
Commuting to job workplace: Public transport	0.6	0.7	1.0	-0.7	1.0	0.7
Eye problems/disorders: Glaucoma	0.3	0.4	0.9	-0.9	-0.4	0.1
Medication: Blood pressure	1.0	1.9	5.4	2.3	-0.1	-0.4
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	-0.5	1.1	0.1
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	-0.5	-1.3	0.9
High cholesterol (Self-reported)	0.8	1.4	3.6	1.9	-0.6	-0.4
Medication: Bendroflumethiazide	1.1	1.6	2.7	0.8	-1.6	-1.2
Medication: Paracetamol	0.5	0.8	1.3	1.1	0.5	-0.8
Medication: Lisinopril	0.5	0.6	1.7	0.4	0.2	1.3
Medication: Atorvastatin	0.3	0.4	0.8	0.3	-0.9	-0.5
Illnesses of father: High blood pressure	1.1	1.4	3.2	1.8	-0.0	-1.0
Alcohol drinker status: Never	1.5	1.7	2.9	1.7	-0.2	-1.5
Ever smoked	0.1	0.2	0.3	0.2	0.6	0.4
Basal metabolic rate	1.2	6.4	13.8	-3.7	-2.1	1.1
Leg fat percentage (left)	0.7	2.5	6.8	0.7	-2.6	-0.6
Arm fat-free mass (left)	0.7	3.8	7.9	-2.8	-1.6	1.0
Number of operations (self-reported)	0.3	0.5	1.0	-0.0	0.6	1.0
Average weekly beer plus cider intake	1.1	1.6	3.2	1.3	-0.0	-1.8
Irritability	3.3	5.6	13.2	1.9	3.6	-0.4
Risk taking	0.3	0.5	1.5	0.1	-1.2	0.1
Ever had prostate specific antigen (PSA) test	2.4	2.7	4.4	-1.8	0.8	2.1
Fractured/broken bones in last 5 years	0.6	0.8	1.8	0.7	0.3	-1.3
Age started oral contraceptive pill	4.0	5.0	6.5	-2.5	1.9	2.3
Diastolic blood pressure, automated reading	0.6	1.9	4.9	2.2	0.9	0.2
Ever depressed for a whole week	1.4	1.7	4.4	0.4	2.1	0.8
Unable to work because of sickness or disability	0.3	0.4	0.9	0.9	0.1	-0.7
Commuting to job workplace: Cycle	0.9	1.0	1.1	-1.0	1.1	1.0
Myopia	0.5	0.7	1.2	1.0	0.0	-1.1
Vascular/heart problems diagnosed by doctor	1.7	4.7	9.4	-3.1	1.4	1.6
Cholesterol lowering medication	0.5	0.7	1.1	1.0	0.1	1.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.0	1.0	-0.7	-0.2
Pain experienced in last month	0.4	0.6	1.7	-0.2	-1.3	0.4
Supplements: Calcium	0.4	0.4	1.2	-1.1	0.1	0.2
Basal cell carcinoma (self-reported)	0.8	1.0	2.3	-1.5	-0.7	-0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.3	-0.6	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	3.5	1.6	-1.9	-0.7
Heart disease (siblings)	0.3	0.3	0.7	-0.4	0.8	-0.3
Alcohol drinker status: Previous	1.3	1.5	2.7	-1.0	-1.6	-0.8
Pack years of smoking	1.0	1.5	2.1	1.3	-1.4	-0.8
Impedance of whole body	2.0	10.3	14.8	-2.6	3.9	3.0
Leg fat mass (left)	1.0	3.8	10.5	-0.7	-3.2	-0.5
Arm predicted mass (left)	0.8	4.1	8.7	-3.0	-1.6	1.0