TWAS hub - PWWP2A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Not Sun Exposed Suprapubic	0.1790	0.0670	9.5e-03	0.131	NA	0.073	NA	0.109	1.2e-07	NA	7.5e-05	NA	1.4e-06
2	TCGA	Breast Invasive Carcinoma	0.0205	0.0150	1.1e-03	0.011	0.014	0.012	NA	0.016	2.0e-03	4.8e-04	1.1e-03	NA	2.0e-04
3	TCGA	Prostate Adenocarcinoma	0.0444	0.0252	5.6e-05	0.045	0.036	0.016	NA	0.040	1.6e-05	9.6e-05	8.0e-03	NA	4.7e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Medication: Paracetamol	8.1	12.6	13.3	3.3	3.6	3.6
Number of live births	7.7	10.9	17.0	2.1	4.1	3.4
Frequency of tiredness / lethargy in last 2 weeks	7.5	12.3	15.5	2.8	3.9	3.7
Current tobacco smoking	7.1	11.7	13.6	2.9	3.6	3.7
Medication: Paracetamol	6.1	10.1	12.6	2.3	3.5	3.5
Smoking status: Current	6.1	9.7	12.2	2.3	3.4	3.5
Fed-up feelings	5.9	10.8	16.4	0.9	3.9	4.1
Supplements: Glucosamine	5.5	7.2	8.6	2.5	2.6	2.9
Qualifications: A levels/AS levels or equivalent	5.4	11.9	14.5	-3.0	-3.8	-3.5
Fasting Glucose	5.3	6.3	12.6	-0.8	-2.4	-3.6
Financial difficulties in last 2 years	5.3	7.1	11.7	1.5	2.7	3.4
Medication: Lansoprazole	5.3	6.0	8.2	1.8	2.5	2.9
Hair/balding pattern: Pattern 2	5.2	6.7	8.7	2.4	2.3	2.9
Age at first live birth	5.0	8.9	10.6	-2.5	-3.1	-3.2
Overall health rating	5.0	10.8	17.8	2.1	4.2	3.1
Lung FEV1/FVC ratio	4.7	23.8	31.4	3.4	5.6	5.4
Illness, injury, bereavement, stress in last 2 years	4.6	5.7	7.6	-2.0	-2.4	-2.8
Loneliness, isolation	4.5	6.2	7.4	2.7	2.1	2.6
Hand grip strength (right)	4.4	12.0	15.9	-2.9	-4.0	-3.4
Knee pain experienced in last month	4.4	6.8	11.0	0.7	3.3	3.0
Pain experienced in last month	4.3	7.2	13.2	-0.7	-3.6	-2.8
Depressed Affect (Nagel 2018)	4.2	8.8	13.2	1.4	3.4	3.6
Medication for pain relief, constipation, heartburn	4.1	6.9	10.1	-0.9	-3.2	-3.2
Unable to work because of sickness or disability	4.1	5.3	7.4	1.7	2.7	2.3
Qualifications: nursing, teaching	4.0	6.2	7.0	-2.5	-2.6	-2.2
Stomach or abdominal pain in last month	3.9	4.9	7.4	1.2	2.4	2.7
Falls in the last year	3.9	5.3	7.7	0.9	2.7	2.8
Health satisfaction	3.9	5.1	8.2	0.6	2.9	2.6
Age at First Birth	3.8	5.5	6.1	-2.1	-2.4	-2.5
Mean Putamen Volume	3.8	4.4	4.9	-2.2	-2.2	-1.8
Frequency of tenseness / restlessness in last 2 weeks	3.7	5.8	8.5	1.5	2.9	2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	3.7	4.8	5.9	1.7	2.4	2.4
Major Depression (MDD)	3.6	4.4	7.1	1.2	2.7	2.2
Multivitamins +/- minerals	3.6	4.6	9.0	3.0	1.1	1.9
Intelligence (Savage-Jansen 2018)	3.5	10.7	13.4	-3.7	-3.2	-2.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.5	4.1	6.9	0.3	2.3	2.6
Fractured/broken bones in last 5 years	3.5	4.6	6.4	1.1	2.5	2.5
Mouth/teeth dental problems	3.3	5.1	9.8	-0.7	-3.1	-2.2
Verbal and Numeric Reasoning (VNR)	3.0	7.3	9.0	-2.6	-2.5	-3.0
Reaction Time	2.9	5.6	7.0	2.0	2.4	2.7
Smoking Status	2.9	6.8	8.9	1.7	3.0	3.0
Hypothyroidism (self reported)	2.9	6.7	7.5	-2.7	-2.5	-2.5
Chronotype (morning person)	2.9	6.7	7.8	2.7	2.8	2.2
Hypothyroidism/myxoedema (self-reported)	2.9	5.6	6.9	-1.8	-2.6	-2.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.9	3.5	4.9	1.6	1.8	2.2
Ever unenthusiastic/disinterested for a whole week	2.8	3.4	4.9	1.2	1.9	2.2
Frequency of depressed mood in last 2 weeks	2.7	3.8	4.9	1.4	2.2	2.1
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	5.6	-2.4	-2.2	-1.6
Guilty feelings	2.7	4.1	5.7	2.0	2.4	1.7
Hearing aid user	2.7	3.1	4.4	0.8	2.0	2.1
High cholesterol (Self-reported)	2.6	4.6	5.9	-2.4	-1.5	-2.4
Average weekly fortified wine intake	2.5	3.0	6.0	-0.8	-2.4	-1.5
Medication: Ramipril	2.5	3.3	6.1	-0.8	-2.5	-1.7
Medication: Ibuprofen	2.5	3.0	4.4	0.9	1.9	2.1
Prostate Cancer	2.4	3.3	4.7	2.2	1.5	1.7
Worrier / anxious feelings	2.4	4.5	7.8	1.6	1.8	2.8
Depression (Nagel 2018)	2.3	3.5	4.7	1.5	1.8	2.2
Type 2 Diabetes (T2D) (2012)	2.3	2.7	5.1	2.3	1.4	1.0
Blood Platelet Count	2.3	26.8	52.0	5.3	0.3	-7.2
Ever used hormone-replacement therapy (HRT)	2.3	3.0	4.4	1.0	2.1	1.9
Pack years adult smoking proportion	2.3	3.6	6.5	1.1	2.5	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	2.3	3.5	5.6	1.0	2.4	2.0
Mean time to correctly identify matches	2.3	4.5	6.9	1.6	2.6	2.0
Long-standing illness, disability or infirmity	2.3	3.4	4.1	1.5	2.0	2.0
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	4.5	0.2	1.9	2.1
Pulse wave Arterial Stiffness index	2.2	2.5	4.7	-2.2	-0.9	-1.4
Age started oral contraceptive pill	2.2	2.8	4.8	-1.4	-1.3	-2.2
Alcohol drinker status: Previous	2.2	2.5	4.9	-0.5	2.2	1.6
Systolic blood pressure, automated reading	2.1	6.0	11.4	-0.5	-2.6	-3.4
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	2.9	1.2	1.7	1.6
Alcohol usually taken with meals	2.1	3.4	6.2	-0.9	-1.8	-2.5
Neuroticism score	2.1	4.5	6.4	1.2	2.5	2.3
Exposure to tobacco smoke outside home	2.1	2.7	4.9	0.8	2.2	1.7
Average weekly champagne plus white wine intake	2.1	2.9	3.3	-1.8	-1.7	-1.5
Diastolic blood pressure, automated reading	2.1	6.6	12.6	-0.6	-2.6	-3.6
Bipolar Disorder (2018)	2.0	3.2	4.2	-1.2	-2.0	-2.0
Neuroticism (Nagel 2018)	2.0	4.7	7.2	1.7	2.0	2.7
Neuroticism	2.0	4.8	6.7	1.1	2.6	2.6
Sensitivity / hurt feelings	2.0	3.4	4.4	1.7	1.7	2.1
Medication: Levothyroxine sodium	2.0	3.4	4.5	-1.4	-2.1	-1.9
Depression (self-reported)	2.0	2.4	3.0	1.5	1.7	1.4
Qualifications: College or University degree	2.0	6.4	11.2	-1.1	-3.3	-2.6
Pack years of smoking	2.0	2.9	5.5	0.9	2.4	1.6
LDL Cholesterol	1.9	3.1	5.5	-1.1	-1.6	-2.4
Relative age of first facial hair	1.9	4.0	6.1	-1.7	-1.7	-2.5
Hypertension (Self-reported)	1.9	5.4	7.0	-2.1	-2.2	-2.6
Neuroticism (2016)	1.8	2.5	3.4	1.4	1.5	1.9
Ever had hysterectomy (womb removed)	1.8	2.0	2.8	1.4	1.2	1.7
Supplements: Zinc	1.8	1.9	3.6	0.5	1.4	1.9
Townsend deprivation index at recruitment	1.8	2.6	4.0	2.0	1.6	1.1
Number of incorrect matches in round	1.8	3.1	4.7	2.2	1.5	1.5
Number of full brothers	1.8	2.3	3.8	1.4	1.9	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	2.9	0.8	1.7	1.7
Wears glasses or contact lenses	1.8	2.1	3.7	-0.0	-1.6	-1.9
High blood pressure	1.7	4.6	6.1	-2.0	-2.0	-2.5
Qualifications: None of the above	1.7	3.6	5.8	1.8	2.4	1.4
Neck or shoulder pain in last month	1.7	2.4	4.8	-0.1	2.2	1.5
Chest pain or discomfort	1.7	2.4	5.2	0.4	2.3	1.4
Miserableness	1.7	3.0	4.5	0.5	2.0	2.1
Commuting to job workplace: Cycle	1.7	2.0	3.4	-0.9	-1.3	-1.8
Medication: Omeprazole (e.g. Zanprol)	1.7	2.0	3.7	0.0	1.9	1.6
Blood Eosinophil Count	1.6	12.3	16.2	-2.5	-4.0	-3.8
Systolic Blood Pressure	1.6	8.2	11.1	-1.7	-3.3	-3.3
Medication: Co-codamol	1.6	1.9	3.0	0.3	1.7	1.6
Pulse wave peak to peak time	1.6	1.9	3.6	1.9	0.7	1.2
Supplements: Vitamin C	1.6	1.9	3.7	-0.3	-1.4	-1.9
Medication: Blood pressure	1.6	3.0	3.5	-1.6	-1.7	-1.9
Cardiovascular Disease	1.5	4.9	6.6	-2.2	-1.8	-2.6
Pain all over the body in last month	1.5	1.6	2.5	1.0	1.6	1.1
Fluid intelligence score	1.5	3.2	3.6	-1.8	-1.9	-1.6
Shortness of breath walking on level ground	1.5	1.7	3.5	0.3	1.9	1.3
Mood swings	1.5	2.6	4.9	0.5	1.7	2.2
Schizophrenia vs Biploar Disorder	1.4	1.9	2.3	1.2	1.5	1.4
Mouth/teeth dental problems: Dentures	1.4	2.4	4.4	1.4	2.1	0.9
Schizophrenia (2018)	1.3	2.7	3.5	1.4	1.6	1.9
Crohns Disease (2017)	1.3	2.8	3.6	1.6	1.9	1.5
Vitamin and mineral supplements	1.3	1.7	4.3	-2.1	-0.5	-0.9
Diabetes (father)	1.3	1.6	3.9	-2.0	-1.0	-0.2
Maternal smoking around birth	1.3	1.9	2.9	1.3	1.7	1.0
Heart attack	1.3	1.7	2.5	0.8	1.6	1.4
Hair/balding pattern: Pattern 3	1.3	2.0	2.9	0.4	-1.7	-1.7
Ever depressed for a whole week	1.3	1.6	3.2	0.6	1.1	1.8
Body Mass Index (BMI) (2010)	1.2	1.6	3.0	-0.2	-1.7	-1.3
Crohns Disease (2012)	1.2	1.9	3.3	1.8	1.0	1.2
Blood clot in the leg (DVT)	1.2	1.5	3.5	-1.9	-0.5	-1.0
Gout (self-reported)	1.2	1.6	2.5	-1.1	-1.6	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.1	0.5	1.5	1.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	3.2	-1.8	-0.4	-1.1
Impedance of whole body	1.2	6.3	10.7	-1.9	-3.3	-2.1
Hand grip strength (left)	1.1	2.8	3.4	-1.6	-1.8	-1.6
Relative age voice broke	1.1	1.7	3.5	-0.0	-1.2	-1.9
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.1	-0.2	-1.4	-1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.3	-1.8	-0.6	-0.6
Impedance of leg (left)	1.1	5.1	9.5	-1.8	-3.1	-1.6
Alcohol intake versus 10 years previously	1.1	1.6	4.4	-2.1	0.3	-0.5
Pulse rate	1.1	1.8	5.0	-2.2	0.3	-0.5
Noisy workplace	1.1	1.3	2.8	-0.3	1.7	1.0
Eye problems/disorders: None of the above	1.1	1.2	2.4	-0.5	-1.0	-1.6
Friendships satisfaction	1.1	1.4	2.7	-0.2	1.2	1.7
Alcohol drinker status: Never	1.1	1.3	1.6	1.0	1.3	1.1
Breast Cancer	1.0	2.3	4.1	0.1	-1.7	-2.0
Height	1.0	18.7	24.4	-4.9	-2.8	-4.9
Waist Hip Ratio (WHR)	1.0	4.6	7.2	-2.0	-1.6	-2.7
Chronic bronchitis/emphysema (father)	1.0	1.1	2.1	-1.5	-1.1	-0.3
Nervous feelings	1.0	1.9	2.3	1.5	1.1	1.5
Standing height	1.0	9.7	14.3	-2.9	-2.5	-3.8
Exposure to tobacco smoke at home	1.0	1.2	2.1	0.3	1.5	1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	2.8	-0.4	0.9	1.7
Medication: Omeprazole	1.0	1.2	1.6	-1.1	1.3	0.8
Suffer from ‘nerves’	1.0	1.5	2.5	0.9	1.6	1.1
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.5	-0.6	-1.6	-0.8
Illnesses of father: None of the above (group 1)	1.0	1.2	2.8	1.7	0.9	0.4
Irritability	1.0	1.6	4.7	-2.2	0.0	-0.3
Risk taking	1.0	1.4	3.1	0.5	1.8	1.0
Vascular/heart problems diagnosed by doctor	1.0	2.6	3.4	1.6	1.4	1.8
Basal cell carcinoma (self-reported)	1.0	1.2	3.4	-1.8	0.1	-0.6
BMI	0.9	5.0	8.3	1.6	2.9	2.0
Impedance of leg (right)	0.9	4.6	7.0	-2.1	-2.6	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	1.7	1.3	1.0	1.0
Taking other prescription medications	0.9	1.4	3.3	0.1	1.8	0.9
Serious illness, injury or assault to yourself	0.9	1.1	2.3	0.7	1.5	0.7
Illnesses of siblings	0.9	1.2	1.7	0.7	1.2	1.3
Impedance of arm (left)	0.9	4.0	6.5	-1.3	-2.5	-2.0
Headache pain in last month	0.9	1.6	2.7	-0.7	1.6	1.3
Leg pain on walking	0.9	1.1	2.4	0.7	1.6	0.7
Back pain experienced in last month	0.9	1.3	2.8	-0.6	1.7	0.9
Medication: Lisinopril	0.9	1.1	1.5	-1.2	-1.1	-0.8
Illnesses of father: High blood pressure	0.9	1.1	1.5	-1.2	-1.0	-0.9
Primary Biliary Cirrhosis	0.8	1.1	1.8	0.2	-1.3	-1.2
Body mass index (BMI)	0.8	3.2	6.6	0.4	2.6	1.7
Had other major operations	0.8	1.0	2.5	-0.2	1.6	0.6
Medication: Simvastatin	0.8	1.2	2.8	-1.7	-0.5	-0.7
Medication: Blood pressure	0.8	1.5	1.8	-1.1	-1.4	-1.2
Family relationship satisfaction	0.8	1.0	1.9	0.3	0.9	1.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.6	0.9	0.6	1.3
Commuting to job workplace: Walk	0.8	0.9	1.3	-1.0	-0.5	-1.1
Alzheimer’s Disease (in father)	0.7	0.8	2.1	1.4	-0.3	-0.3
Lupus	0.7	1.0	1.7	0.7	-1.0	-1.3
Hearing difficulty/problems: Yes	0.7	1.1	1.8	-0.2	1.2	1.3
Medication: Atenolol	0.7	0.9	1.6	-1.3	-0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	2.7	0.1	1.4	1.6
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.5	-1.6	-0.1	0.2
Medication: Aspirin	0.7	1.0	1.6	0.7	1.3	0.9
Illnesses of siblings: Diabetes	0.7	0.9	1.3	0.9	0.8	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.0	-1.4	-1.1	-1.0
Medication for cholesterol	0.7	1.0	2.1	0.4	0.9	1.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	-0.8	-1.1	-0.9
Myopia	0.7	1.0	1.7	-1.3	-1.1	-0.1
Cholesterol lowering medication	0.7	1.1	2.1	-0.9	-0.4	-1.5
Alzheimer’s Disease (including proxy)	0.6	0.8	2.4	1.6	0.2	-0.1
Bipolar Disorder (2011)	0.6	0.5	1.1	0.5	-0.6	-1.0
Schizophrenia (2014)	0.6	1.3	1.7	0.8	1.2	1.3
Impedance of arm (right)	0.6	2.7	4.1	-1.2	-2.0	-1.7
Hip circumference	0.6	2.6	5.6	0.2	2.4	1.5
Leg fat percentage (right)	0.6	2.1	3.5	-0.8	1.9	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	-0.7	-1.2	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.1	-0.2	1.4	0.2
Age at last live birth	0.6	0.9	1.6	-0.4	-1.3	-1.0
Smoking status: Previous	0.6	0.9	1.0	-0.9	-1.0	-1.0
Medication: Aspirin	0.6	0.8	1.3	0.6	1.1	0.9
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.4	0.6	1.2	0.8
Alzheimer’s Disease (in mother)	0.5	0.6	0.9	0.9	1.0	0.3
Ovarian Cancer	0.5	0.7	2.0	1.4	0.2	-0.1
Age when periods started (menarche)	0.5	1.1	2.1	-1.5	-0.9	-0.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.5	0.6	1.2	0.1
Arm fat percentage (right)	0.5	1.9	4.0	-0.0	2.0	1.3
Happiness	0.5	0.6	1.2	0.1	0.8	1.1
Medication: Cholesterol lowering	0.5	0.8	1.4	-1.2	-0.8	-0.5
Length of working week for main job	0.5	0.5	0.9	0.5	0.6	1.0
Tense / ‘highly strung’	0.5	0.9	2.0	1.4	0.4	0.7
Comparative body size at age 10	0.5	1.4	1.9	-1.2	-0.8	-1.4
Arm fat percentage (left)	0.5	1.8	3.8	0.0	1.9	1.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	1.5	-1.2	1.0	0.4
Financial situation satisfaction	0.5	0.6	1.3	0.7	0.2	1.1
Leg fat percentage (left)	0.5	1.9	3.3	-0.5	1.8	1.5
Worry (Nagel 2018)	0.4	0.9	1.5	1.1	0.4	1.2
Medication for hormone replacement therapy	0.4	0.5	1.4	1.2	0.0	-0.1
Illnesses of mother	0.4	0.5	0.6	-0.8	-0.7	-0.7
Loud music exposure frequency	0.4	0.4	0.9	-0.9	0.6	0.4
Heart disease (mother)	0.4	0.5	0.9	0.1	-0.9	-0.7
Leg fat mass (right)	0.4	1.5	2.6	-1.1	1.6	0.9
Illnesses of father: Heart disease	0.4	0.6	1.3	-1.1	-0.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	0.6	0.8	1.2
Ever taken oral contraceptive pill	0.4	0.4	0.6	-0.8	0.7	0.4
Eye problems/disorders: Glaucoma	0.4	0.4	0.8	0.9	-0.1	0.7
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	0.6	1.1	0.0
Average weekly beer plus cider intake	0.4	0.5	1.4	1.2	0.2	0.3
Heart disease (siblings)	0.4	0.5	1.6	-0.1	-0.1	-1.2
Leg fat mass (left)	0.4	1.5	2.6	-1.0	1.6	0.9
HDL Cholesterol	0.3	0.5	0.7	-0.8	-0.8	-0.4
Rheumatoid Arthritis	0.3	0.4	1.1	0.4	0.0	1.1
Blood White Count	0.3	2.1	6.1	2.5	0.5	0.3
Heel T-Score	0.3	2.5	6.4	0.4	-1.0	-2.5
Allergy or Eczema	0.3	0.8	1.6	-0.3	-0.9	-1.3
Tanning	0.3	4.0	6.4	2.5	1.1	2.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.6	-0.8	0.5	-0.5
Diabetes (mother)	0.3	0.4	0.7	0.6	-0.8	-0.3
Sitting height	0.3	1.9	3.8	-1.2	-0.7	-2.0
Waist circumference	0.3	1.3	3.3	-0.5	1.8	0.5
Father’s age at death	0.3	0.4	0.9	0.2	0.5	0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.4	0.7	1.2	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.8	0.4	1.4	1.0
Arm fat mass (right)	0.3	1.4	3.5	-0.2	1.9	0.9
Peak expiratory flow (PEF)	0.3	0.8	1.2	-0.0	1.1	1.1
Glaucoma (self-reported)	0.3	0.3	0.5	0.7	-0.1	0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.7	0.7	0.4	0.8
Birth weight	0.3	0.7	1.8	1.3	0.4	0.5
Worry too long after embarrassment	0.3	0.4	1.3	1.1	-0.1	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.6	-0.8	-0.4	-0.5
Pulse rate, automated reading	0.3	0.9	1.9	-0.5	1.4	0.6
Alcohol intake frequency.	0.3	0.7	1.5	-0.1	1.2	0.7
Eye problems/disorders: Cataract	0.3	0.3	0.5	-0.2	0.6	0.7
Asthma (self-reported)	0.3	0.6	0.9	0.4	0.9	0.9
Arm fat mass (left)	0.3	1.3	3.0	-0.3	1.7	0.8
Mother’s age at death	0.3	0.4	0.6	0.8	0.1	0.8
Supplements: Calcium	0.3	0.3	0.9	0.9	-0.0	-0.3
Irritable Bowel Disease (IBD)	0.2	0.5	1.1	1.1	0.4	0.3
Ulcerative Colitis (UC)	0.2	0.4	0.6	0.1	-0.7	-0.8
Coronary Artery Disease (CAD)	0.2	0.3	0.6	0.3	-0.8	-0.3
Ulcerative Colitis	0.2	0.3	0.6	0.1	-0.8	-0.4
Blood Red Count	0.2	2.2	5.6	2.4	0.9	-0.0
Respiratory disease	0.2	0.4	0.5	0.3	0.7	0.7
Angina	0.2	0.3	0.7	-0.4	0.8	0.2
Medication: Metformin	0.2	0.2	0.4	0.4	0.4	0.7
Leg fat-free mass (left)	0.2	0.8	1.8	-0.8	1.3	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.6	0.7	0.2	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.8	0.1	0.9	0.7
Leg predicted mass (left)	0.2	0.8	1.8	-0.8	1.3	-0.3
Hearing difficulty/problems with background noise	0.2	0.3	0.8	-0.2	0.9	-0.2
Forced vital capacity (FVC)	0.2	0.6	1.1	-0.3	-0.7	-1.1
Weight	0.2	1.0	2.0	-0.9	1.4	0.1
Asthma	0.2	0.5	0.7	0.6	0.9	0.6
Birth weight of first child	0.2	0.5	0.5	0.6	0.7	0.7
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.8	0.9	0.3	0.1
Medication: Amlodipine	0.2	0.3	0.5	-0.1	0.6	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.5	0.5	-0.1
High blood pressure (siblings)	0.2	0.2	0.4	-0.2	-0.6	-0.5
Body fat percentage	0.2	0.6	1.0	-0.8	1.0	0.6
Number of children fathered	0.2	0.3	0.4	-0.6	0.2	-0.6
Angina (self-reported)	0.2	0.3	0.7	-0.4	0.8	0.2
Whole body fat mass	0.2	0.8	1.5	-0.8	1.2	0.3
Comparative height size at age 10	0.2	1.2	1.3	-1.1	-1.0	-1.1
Number of full sisters	0.2	0.2	0.5	0.1	-0.1	-0.7
Ever had bowel cancer screening	0.2	0.2	0.6	-0.2	-0.0	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.3	-0.4	-0.6
Osteoporosis (self-reported)	0.2	0.2	0.4	0.6	-0.2	-0.5
Osteoarthritis (self-reported)	0.2	0.2	0.4	-0.6	0.5	0.0
Number of self-reported non-cancer illnesses	0.2	0.3	0.6	-0.5	0.4	-0.7
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	-0.4	0.7	0.0
Commuting to job workplace: Public transport	0.2	0.2	0.3	0.5	0.3	0.6
Arm predicted mass (left)	0.2	0.8	1.5	-1.2	0.5	-0.8
HbA1C	0.1	0.1	0.1	-0.1	0.3	-0.4
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.1	-0.4	-0.3	0.4
Lung FVC	0.1	0.6	1.7	1.3	0.1	0.2
Hair Pigment	0.1	2.6	4.8	-0.0	-1.8	-2.2
Number of treatments/medications taken	0.1	0.2	0.3	-0.1	0.6	0.6
Severe depression (siblings)	0.1	0.1	0.2	-0.2	0.5	0.3
Trunk fat percentage	0.1	0.5	1.1	-1.0	0.6	-0.0
Qualifications: CSEs or equivalent	0.1	0.1	0.4	-0.2	0.0	0.6
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.5	0.5	-0.5	-0.7
High blood pressure (mother)	0.1	0.2	0.5	-0.1	-0.7	-0.1
Trunk fat mass	0.1	0.6	1.2	-1.1	0.8	-0.2
Past tobacco smoking	0.1	0.2	0.4	0.7	0.5	0.2
Had menopause	0.1	0.1	0.1	-0.0	0.3	-0.3
Trunk fat-free mass	0.1	0.5	0.8	-0.6	0.9	-0.5
Time employed in main current job	0.1	0.1	0.2	-0.5	0.2	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	-0.1	0.0	0.5
Prospective memory result	0.1	0.1	0.2	0.4	0.3	-0.3
Lung cancer (father)	0.1	0.1	0.2	0.5	-0.2	-0.1
Trunk predicted mass	0.1	0.5	0.5	-0.7	0.7	-0.7
Breastfed as a baby	0.1	0.1	0.1	0.3	0.0	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	-0.1	0.8	0.1
Pulse wave reflection index	0.1	0.2	0.3	-0.1	-0.6	-0.4
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-0.7	-0.5	-1.0
Arm fat-free mass (right)	0.1	0.6	1.0	-1.0	0.6	-0.5
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.3	0.7	0.3
Migraine (self-reported)	0.1	0.1	0.3	-0.0	0.5	0.2
Arm predicted mass (right)	0.1	0.5	0.8	-0.9	0.6	-0.6
Had major operations	0.1	0.2	0.4	-0.6	-0.0	-0.4
Whole body fat-free mass	0.1	0.6	1.3	-0.6	1.1	-0.4
Leg fat-free mass (right)	0.1	0.7	1.4	-0.7	1.2	-0.3
Average weekly red wine intake	0.1	0.1	0.3	-0.4	-0.2	-0.5
Breast cancer (self-reported)	0.1	0.1	0.2	0.2	0.4	0.4
Medication: Gliclazide	0.1	0.2	0.3	0.5	0.2	0.4
Whole body water mass	0.1	0.6	1.1	-0.6	1.1	-0.5
Leg predicted mass (right)	0.1	0.6	1.3	-0.7	1.1	-0.4
Medication: Atorvastatin	0.1	0.1	0.3	0.2	0.5	-0.0
Basal metabolic rate	0.1	0.7	1.6	-0.6	1.3	-0.3
Arm fat-free mass (left)	0.1	0.5	1.0	-0.7	1.0	-0.3
Number of operations (self-reported)	0.1	0.2	0.5	0.0	0.7	0.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	0.2	0.5	-0.2
Bipolar Disorder or Schizophrenia	0.0	0.0	0.1	0.3	0.1	0.2
Triglycerides	0.0	0.0	0.0	0.2	0.2	-0.1
Average weekly spirits intake	0.0	0.1	0.1	-0.1	0.4	-0.1
Allergy	0.0	0.1	0.2	-0.4	-0.3	0.2
Diabetes (self-reported)	0.0	0.0	0.1	0.2	-0.3	-0.0
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.0	0.3	-0.1
Medication: Allopurinol	0.0	0.0	0.0	0.2	0.0	-0.1
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.1	-0.1	0.4
Mineral and other dietary supplements	0.0	0.0	0.1	-0.3	-0.0	-0.1
Medication: Bendroflumethiazide	0.0	0.0	0.0	-0.2	-0.2	0.2
Ever smoked	0.0	0.1	0.1	-0.3	0.2	0.3

Hub : Genes

PWWP2A

Models

Trait associations