TWAS hub - PYDC1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.1044	0.0422	7.5e-05	0.043	0.047	0.046	0.052	0.042	2.7e-06	1.0e-06	1.2e-06	2.7e-07	4.0e-06
2	TCGA	Breast Invasive Carcinoma	0.0358	0.0319	2.7e-03	0.010	0.003	0.007	NA	0.007	2.5e-03	8.5e-02	1.3e-02	NA	9.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Tinnitus: Yes, now most or all of the time	10.8	12.7	13.7	3.7	3.4
Hip circumference	8.8	38.0	39.6	6.3	6.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.8	16.5	24.9	-5.0	-2.8
Leg fat mass (right)	7.6	29.3	30.8	5.5	5.3
Leg fat mass (left)	7.5	29.2	30.6	5.5	5.3
Body mass index (BMI)	7.3	31.0	34.0	5.8	5.3
Illnesses of siblings	7.2	10.1	14.1	-2.5	-3.7
Arm fat mass (left)	6.9	28.1	31.4	5.6	5.0
Arm fat mass (right)	6.6	27.2	30.1	5.5	4.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	6.6	7.8	8.7	-2.6	-3.0
Leg fat percentage (left)	6.6	23.9	25.4	5.0	4.7
Arm fat percentage (right)	6.3	24.7	25.6	5.1	4.9
Arm fat percentage (left)	6.3	25.3	26.9	5.2	4.9
Leg fat percentage (right)	6.0	21.8	22.3	4.7	4.6
Whole body fat mass	6.0	25.1	25.9	5.1	4.9
Prospective memory result	5.9	7.3	7.6	-2.8	-2.6
Body fat percentage	5.9	23.4	23.8	4.9	4.8
Comparative body size at age 10	5.8	16.1	18.9	4.3	3.6
Smoking status: Previous	5.8	8.7	11.3	3.4	2.5
Relative age voice broke	5.6	8.6	15.9	1.1	4.0
Waist circumference	5.6	20.6	23.0	4.3	4.8
Weight	5.4	26.6	27.0	5.2	5.1
Wears glasses or contact lenses	5.4	6.2	8.4	2.0	2.9
Trunk fat mass	5.2	22.5	22.6	4.8	4.7
Worry (Nagel 2018)	4.7	9.9	11.7	-3.4	-2.8
BMI	4.7	27.3	30.8	5.5	4.9
Smoking Status	4.7	11.2	11.7	3.3	3.4
Trunk fat percentage	4.7	18.8	19.7	4.2	4.4
Medication: Allopurinol	4.5	5.9	7.3	-2.7	-2.1
Hayfever/allergic rhinitis (self-reported)	4.4	5.8	11.3	-3.4	-0.5
Worrier / anxious feelings	4.3	8.1	11.7	-2.1	-3.4
Hearing aid user	4.3	4.9	6.5	2.5	1.8
Qualifications: nursing, teaching	4.2	6.5	8.3	-2.2	-2.9
Past tobacco smoking	4.1	7.5	7.9	-2.8	-2.6
Forced expiratory volume in 1-second (FEV1), Best measure	4.1	12.9	17.1	-4.1	-3.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.1	4.8	8.9	-3.0	-0.9
Severe depression (siblings)	4.0	4.5	4.6	-2.1	-2.1
Alzheimer’s Disease (including proxy)	3.9	5.6	8.5	-1.6	-2.9
Relative age of first facial hair	3.9	8.1	11.5	2.2	3.4
High blood pressure (siblings)	3.9	5.7	8.6	1.6	2.9
Hand grip strength (left)	3.7	9.7	10.0	3.1	3.2
Leg predicted mass (left)	3.4	17.8	18.7	4.1	4.3
Knee pain experienced in last month	3.4	5.3	6.0	2.4	2.2
Medication: Omeprazole	3.3	3.9	7.5	-2.7	-0.6
Medication: Bendroflumethiazide	3.3	5.0	8.3	2.9	1.3
Arm predicted mass (left)	3.3	16.9	18.8	4.3	3.9
Lung FVC	3.2	16.4	16.8	-4.0	-4.1
Leg fat-free mass (left)	3.2	17.2	17.5	4.1	4.2
Forced vital capacity (FVC)	3.2	12.4	12.8	-3.5	-3.6
Vascular/heart problems diagnosed by doctor	3.2	8.7	13.0	-3.6	-2.1
Illnesses of siblings: Diabetes	3.1	3.8	4.8	2.2	1.7
Arm fat-free mass (left)	3.1	15.9	17.6	4.2	3.8
Stomach or abdominal pain in last month	3.0	3.7	5.1	-1.5	-2.3
Birth weight	3.0	6.4	8.1	2.2	2.9
Forced vital capacity (FVC), Best measure	3.0	11.0	12.6	-3.5	-3.1
Number of full brothers	3.0	3.7	4.7	2.2	1.7
Medication: Ramipril	2.9	3.7	5.8	2.4	1.3
Number of live births	2.9	4.1	5.2	1.7	2.3
Forced expiratory volume in 1-second (FEV1)	2.9	9.7	11.0	-3.3	-2.9
Commuting to job workplace: Walk	2.9	3.1	5.4	-2.3	1.0
Leg predicted mass (right)	2.9	15.4	15.5	3.9	3.9
Basal metabolic rate	2.9	16.2	16.6	4.1	4.0
Lupus	2.8	4.3	7.8	-0.9	-2.8
Arm fat-free mass (right)	2.8	14.5	16.4	4.0	3.6
Arm predicted mass (right)	2.8	14.5	16.8	4.1	3.5
Leg fat-free mass (right)	2.8	14.9	15.1	3.9	3.8
Waist Hip Ratio (WHR)	2.7	12.2	16.7	-4.1	-2.8
Medication: Seretide 50 evohaler	2.7	3.1	3.7	-1.9	-1.6
Irritability	2.7	4.5	5.2	-2.3	-2.0
Number of incorrect matches in round	2.6	4.3	6.0	-1.6	-2.5
Nervous feelings	2.6	4.8	7.1	-2.7	-1.6
Osteoarthritis (self-reported)	2.6	3.4	6.7	-0.4	-2.6
Blood Red Count	2.5	24.0	31.6	-4.0	-5.6
Had menopause	2.5	3.1	4.5	1.3	2.1
Pain all over the body in last month	2.5	2.7	3.8	2.0	1.3
Ever smoked	2.5	4.3	5.3	1.8	2.3
Alzheimer’s Disease (in mother)	2.4	2.8	4.7	-1.0	-2.2
Crohns Disease (2017)	2.4	5.2	7.9	-2.8	-1.6
Hand grip strength (right)	2.4	6.6	6.7	2.6	2.6
Multivitamins +/- minerals	2.4	3.1	3.3	1.8	1.7
Medication: Ibuprofen	2.4	2.9	4.2	1.3	2.1
Medication: Blood pressure	2.4	4.6	6.0	2.4	1.8
Impedance of whole body	2.4	12.4	15.8	-4.0	-3.0
Impedance of arm (right)	2.3	10.7	15.5	-3.9	-2.4
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	4.7	1.0	2.2
Fractured/broken bones in last 5 years	2.3	3.0	5.3	0.8	2.3
Breast Cancer	2.2	5.3	7.2	2.7	1.9
Ever had bowel cancer screening	2.2	2.5	3.8	2.0	1.1
Whole body water mass	2.2	12.4	12.8	3.6	3.5
Hayfever, allergic rhinitis or eczema	2.1	4.5	8.3	-2.9	-0.8
Impedance of arm (left)	2.1	9.7	13.3	-3.6	-2.5
Hypertension (Self-reported)	2.1	5.9	7.4	2.7	2.1
Neuroticism (Nagel 2018)	2.0	4.7	5.2	-2.3	-2.0
Impedance of leg (right)	2.0	9.6	11.9	-3.5	-2.7
High blood pressure	2.0	5.5	7.4	2.7	1.9
Father’s age at death	2.0	2.7	4.6	-2.1	-0.9
Whole body fat-free mass	2.0	11.7	11.8	3.4	3.4
Irritable Bowel Disease (IBD)	1.9	4.5	5.8	-2.4	-1.8
Crohns Disease (2012)	1.9	3.1	6.1	-2.5	0.0
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	4.3	-0.8	-2.1
Qualifications: CSEs or equivalent	1.9	2.5	3.1	1.4	1.8
Serious illness, injury or assault to yourself	1.8	2.2	2.9	-1.2	-1.7
Impedance of leg (left)	1.8	8.9	10.1	-3.2	-2.8
Diastolic blood pressure, automated reading	1.8	5.6	7.0	2.0	2.6
Prostate Cancer	1.7	2.4	2.5	-1.5	-1.6
Cardiovascular Disease	1.7	5.5	5.8	2.4	2.3
Qualifications: A levels/AS levels or equivalent	1.7	3.8	7.6	-2.8	-0.3
Myopia	1.7	2.5	3.2	1.3	1.8
Pack years of smoking	1.7	2.6	4.5	2.1	0.8
Triglycerides	1.6	2.6	5.2	2.3	0.0
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.6	1.9	0.0
Allergy or Eczema	1.6	4.1	7.6	-2.8	-0.8
Hypothyroidism (self reported)	1.6	3.6	7.1	-0.3	-2.7
Vitamin and mineral supplements	1.6	2.1	2.6	-1.3	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	4.1	-0.2	-2.0
Wheeze or whistling in the chest in last year	1.6	2.9	4.6	1.1	2.1
Number of children fathered	1.6	1.8	2.5	1.6	1.1
Alcohol intake frequency.	1.6	3.7	6.4	2.5	1.0
Leg pain on walking	1.6	2.0	3.7	1.9	-0.5
Alcohol drinker status: Previous	1.6	1.8	2.1	1.3	1.4
Hair/balding pattern: Pattern 3	1.5	2.3	3.5	1.9	1.0
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	3.6	1.1	1.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.4	-1.8	-0.6
Hearing difficulty/problems: Yes	1.4	2.2	3.6	0.9	1.9
Ever had hysterectomy (womb removed)	1.4	1.6	3.2	1.8	0.2
Ever unenthusiastic/disinterested for a whole week	1.4	1.7	2.0	-1.4	-1.2
Suffer from ‘nerves’	1.4	2.3	4.1	-2.0	-0.6
Pain experienced in last month	1.4	2.4	3.7	-1.0	-1.9
Chronotype (morning person)	1.3	3.0	6.0	2.5	-0.1
Medication: Metformin	1.3	1.8	1.9	1.3	1.4
Trunk fat-free mass	1.3	7.4	8.2	2.9	2.6
Trunk predicted mass	1.3	7.6	8.4	2.9	2.6
Supplements: Vitamin C	1.3	1.5	3.0	-1.7	0.2
Neuroticism	1.2	2.9	3.2	-1.8	-1.6
Chronic bronchitis/emphysema (father)	1.2	1.4	2.3	0.7	1.5
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	2.3	0.8	1.5
Health satisfaction	1.2	1.6	2.7	1.6	0.8
Ever taken oral contraceptive pill	1.2	1.3	2.3	-0.6	1.5
Unable to work because of sickness or disability	1.2	1.6	3.0	1.7	-0.4
Cholesterol lowering medication	1.2	1.8	3.3	1.8	0.5
Ulcerative Colitis (UC)	1.1	2.1	2.2	-1.4	-1.5
Neuroticism (2016)	1.1	1.7	3.3	-1.8	0.0
Type 2 Diabetes (T2D) (2018)	1.1	2.1	3.6	1.9	0.8
Pack years adult smoking proportion	1.1	1.7	3.1	1.8	0.6
Medication: Simvastatin	1.1	1.6	1.9	1.1	1.4
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	3.4	-1.8	0.1
Medication: Blood pressure	1.1	2.0	3.2	1.8	0.9
Medication for cholesterol	1.1	1.6	2.8	-1.7	-0.7
Miserableness	1.1	1.9	2.7	1.6	1.1
Fasting Glucose	1.0	1.2	2.4	1.6	0.0
Ever used hormone-replacement therapy (HRT)	1.0	1.3	2.6	-0.2	-1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.2	-1.5	0.1
Hair/balding pattern: Pattern 2	1.0	1.3	2.5	-1.6	-0.1
Neuroticism score	1.0	2.0	2.5	-1.3	-1.6
Glaucoma (self-reported)	1.0	1.2	1.7	-0.9	-1.3
Qualifications: College or University degree	1.0	3.0	4.8	-2.2	-1.1
Osteoporosis (self-reported)	1.0	1.3	1.3	1.2	1.1
Commuting to job workplace: Cycle	1.0	1.1	2.3	0.1	1.5
Basal cell carcinoma (self-reported)	1.0	1.2	2.3	-0.4	1.5
Bipolar Disorder or Schizophrenia	0.9	2.3	4.6	-2.1	0.0
Mean Putamen Volume	0.9	1.0	2.1	1.4	0.0
Allergy	0.9	2.0	3.9	2.0	-0.3
Medication: Cholesterol lowering	0.9	1.4	1.8	1.3	1.0
Breastfed as a baby	0.9	1.2	2.2	-0.3	1.5
Blood clot in the leg (DVT)	0.9	1.1	1.7	0.7	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.9	1.4	-0.4
Mean time to correctly identify matches	0.9	1.7	2.5	1.6	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	-1.4	-0.3
Illnesses of father: None of the above (group 1)	0.9	1.1	1.5	-1.2	-0.8
Schizophrenia (2018)	0.8	1.6	3.3	-1.8	0.0
Reaction Time	0.8	1.6	3.0	1.7	-0.5
Heel T-Score	0.8	6.7	10.9	-3.3	-1.6
Medication for hormone replacement therapy	0.8	0.9	1.8	-0.1	-1.3
Mouth/teeth dental problems	0.8	1.2	1.6	-1.3	-0.8
Length of working week for main job	0.8	0.9	1.7	1.3	-0.1
Emphysema/chronic bronchitis	0.8	0.9	1.6	0.4	1.3
Heart disease (mother)	0.8	0.9	1.9	-0.0	-1.4
Medication: Aspirin	0.8	1.0	1.6	1.3	0.6
Illnesses of father: Heart disease	0.8	1.1	1.8	0.6	-1.3
Medication: Aspirin	0.8	1.1	2.1	1.4	0.1
High cholesterol (Self-reported)	0.8	1.5	2.4	1.5	0.8
Heart disease (siblings)	0.8	0.9	1.3	1.1	0.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.1	-1.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.4	1.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.3	-0.2	-1.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.1	-1.1	-0.7
Exposure to tobacco smoke at home	0.7	0.8	1.6	1.3	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.6	-0.7	-1.3
Hair/balding pattern: Pattern 4	0.7	1.7	2.0	-1.2	-1.4
Pulse wave reflection index	0.7	0.8	1.3	1.2	0.6
Age at first live birth	0.7	1.2	1.5	-0.9	-1.2
Shortness of breath walking on level ground	0.7	0.8	1.2	0.7	1.1
Had major operations	0.7	0.8	1.5	-0.3	-1.2
Eye problems/disorders: Cataract	0.7	0.8	1.7	-1.3	0.1
Ever depressed for a whole week	0.7	0.8	1.0	-1.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.3	0.7	1.1
Blood Eosinophil Count	0.6	4.9	8.2	-2.9	-1.2
Angina	0.6	0.8	1.1	1.1	-0.6
Current tobacco smoking	0.6	0.9	1.2	0.8	1.1
Medication: Levothyroxine sodium	0.6	1.0	2.1	0.1	-1.4
Had other major operations	0.6	0.7	1.4	1.2	0.2
Lung cancer (father)	0.6	0.7	1.3	-0.3	-1.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	-1.3	-0.7
Gout (self-reported)	0.6	0.9	0.9	-0.9	-0.9
Worry too long after embarrassment	0.6	0.9	0.9	-1.0	-1.0
Number of full sisters	0.6	0.7	0.8	0.8	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	1.2	0.1
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.2	1.1
Eye problems/disorders: Glaucoma	0.6	0.7	0.8	-0.9	-0.7
Medication: Lisinopril	0.6	0.8	1.5	0.2	1.2
Bipolar Disorder (2011)	0.5	0.5	1.0	-1.0	0.0
HDL Cholesterol	0.5	0.8	1.6	-1.3	0.0
Townsend deprivation index at recruitment	0.5	0.7	1.1	-1.1	0.5
Sitting height	0.5	3.2	5.2	-2.3	-1.1
Alcohol intake versus 10 years previously	0.5	0.7	1.1	-0.5	-1.1
Depression (self-reported)	0.5	0.6	0.9	0.5	-1.0
Illnesses of mother	0.5	0.7	0.9	-1.0	0.6
Medication: Paracetamol	0.5	0.9	1.0	0.9	1.0
Angina (self-reported)	0.5	0.6	1.1	1.0	-0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.8	0.9	0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.6	0.7	-0.8	-0.8
Bipolar Disorder (2018)	0.4	0.6	1.3	-1.1	0.0
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.1	-1.4	0.5
Schizophrenia (2014)	0.4	1.0	1.9	-1.4	0.0
Blood White Count	0.4	2.9	3.9	-2.0	1.4
Number of treatments/medications taken	0.4	0.8	1.1	0.7	1.1
Diabetes (self-reported)	0.4	0.6	0.8	0.9	0.6
Fluid intelligence score	0.4	0.8	1.6	-0.1	1.3
Noisy workplace	0.4	0.5	0.8	-0.4	-0.9
Tense / ‘highly strung’	0.4	0.7	0.8	-0.7	-0.9
Birth weight of first child	0.4	0.8	0.8	0.9	0.9
Headache pain in last month	0.4	0.6	1.2	-0.2	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.5	0.2	-1.2
Eye problems/disorders: None of the above	0.4	0.5	0.8	0.9	0.3
Comparative height size at age 10	0.4	2.3	4.1	-2.0	-0.8
Family relationship satisfaction	0.4	0.5	0.9	-0.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	0.8	-0.8	-0.9
Loneliness, isolation	0.4	0.6	1.1	0.1	-1.1
Average weekly champagne plus white wine intake	0.4	0.6	1.1	0.2	1.1
Guilty feelings	0.4	0.6	1.1	-0.3	-1.1
Mother’s age at death	0.4	0.5	1.0	0.3	-1.0
Supplements: Calcium	0.4	0.5	0.8	-0.4	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	0.9	0.0
Height	0.3	6.3	6.9	2.6	2.4
Lung FEV1/FVC ratio	0.3	1.6	3.3	-1.8	0.0
Sensitivity / hurt feelings	0.3	0.5	0.6	-0.6	-0.8
Supplements: Zinc	0.3	0.4	0.7	-0.8	-0.1
Diabetes (mother)	0.3	0.4	0.7	0.8	-0.2
Maternal smoking around birth	0.3	0.4	0.7	0.2	0.8
Medication: Atenolol	0.3	0.4	0.7	0.8	0.2
Financial difficulties in last 2 years	0.3	0.4	0.7	0.8	0.3
Time employed in main current job	0.3	0.3	0.6	-0.8	-0.0
Happiness	0.3	0.3	0.5	-0.3	-0.7
Asthma	0.3	0.5	1.0	-0.2	1.0
Pulse wave Arterial Stiffness index	0.3	0.3	0.3	0.6	0.5
Exposure to tobacco smoke outside home	0.3	0.4	0.6	-0.8	0.4
Pulse wave peak to peak time	0.3	0.4	0.5	-0.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.8	0.9	0.0
Migraine (self-reported)	0.3	0.4	0.4	-0.6	-0.6
Pulse rate, automated reading	0.3	1.1	1.4	-0.9	1.2
Diabetes diagnosed by doctor	0.3	0.4	0.6	0.5	0.8
Friendships satisfaction	0.3	0.3	0.3	-0.6	0.6
Back pain experienced in last month	0.3	0.4	0.6	-0.8	0.5
Mineral and other dietary supplements	0.3	0.3	0.7	0.8	0.0
Smoking status: Current	0.3	0.4	0.8	0.3	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	0.8	0.9	-0.3
Medication: Paracetamol	0.3	0.5	0.7	0.5	0.8
Medication: Atorvastatin	0.3	0.4	0.7	0.9	-0.2
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.2	0.9
Number of operations (self-reported)	0.3	0.5	0.7	0.6	-0.8
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.6	-0.8	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	0.9	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	0.1	0.9
Primary Biliary Cirrhosis	0.2	0.3	0.6	0.8	0.0
Systolic blood pressure, automated reading	0.2	0.7	1.2	1.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	-0.9	-0.3
Qualifications: None of the above	0.2	0.4	0.5	0.6	0.7
Heart attack	0.2	0.3	0.5	0.7	0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	0.1	-0.7
Peak expiratory flow (PEF)	0.2	0.4	0.5	-0.7	-0.5
Medication: Amlodipine	0.2	0.2	0.3	0.5	0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.4	0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.6	0.8	0.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.3	0.5	-0.5
Asthma (self-reported)	0.2	0.3	0.4	-0.5	0.6
Financial situation satisfaction	0.2	0.2	0.4	0.6	-0.1
Average weekly beer plus cider intake	0.2	0.3	0.5	-0.7	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	0.3	0.4	-0.6
Depression (Nagel 2018)	0.1	0.1	0.2	-0.2	-0.4
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.4	0.0
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.4	-0.4
Major Depression (MDD)	0.1	0.1	0.2	-0.5	0.1
HbA1C	0.1	0.2	0.3	-0.6	0.0
Systolic Blood Pressure	0.1	0.3	0.5	-0.2	-0.7
Tanning	0.1	0.8	1.0	-1.0	-0.8
Average weekly spirits intake	0.1	0.2	0.3	0.1	0.5
Diabetes (father)	0.1	0.1	0.1	-0.3	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.2	0.4	-0.5
Taking other prescription medications	0.1	0.2	0.4	-0.6	-0.1
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.3	-0.6	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.1	0.4
High blood pressure (mother)	0.1	0.2	0.3	0.6	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.2	0.4
Medication: Lansoprazole	0.1	0.1	0.2	0.1	-0.5
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.0	-0.5
Loud music exposure frequency	0.1	0.1	0.1	0.3	0.3
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.2	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.0	-0.5
Neck or shoulder pain in last month	0.1	0.2	0.2	0.5	0.4
Overall health rating	0.1	0.1	0.2	0.5	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.0	0.4
Average weekly red wine intake	0.1	0.1	0.2	0.2	-0.4
Medication: Gliclazide	0.1	0.1	0.3	-0.2	0.5
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.4	-0.3
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.2
Risk taking	0.1	0.2	0.3	0.5	0.3
Ovarian Cancer	0.0	0.1	0.1	-0.1	-0.3
Age at First Birth	0.0	0.0	0.0	-0.1	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.1	-0.3	0.0
Rheumatoid Arthritis	0.0	0.0	0.0	-0.0	0.0
Ulcerative Colitis	0.0	0.0	0.1	0.2	0.0
Blood Platelet Count	0.0	0.1	0.1	-0.3	0.2
Respiratory disease	0.0	0.1	0.1	-0.3	-0.3
Hair Pigment	0.0	0.7	0.9	-0.9	-0.7
Medication: Co-codamol	0.0	0.0	0.1	-0.0	-0.3
Average weekly fortified wine intake	0.0	0.0	0.0	0.0	-0.1
Fed-up feelings	0.0	0.0	0.1	0.1	0.2
Age when periods started (menarche)	0.0	0.0	0.0	-0.2	-0.1
Supplements: Glucosamine	0.0	0.0	0.0	-0.2	-0.1
Alcohol usually taken with meals	0.0	0.0	0.1	-0.3	0.0
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.1	0.2
Falls in the last year	0.0	0.0	0.0	0.2	0.2
Pulse rate	0.0	0.0	0.0	-0.0	-0.0
Standing height	0.0	0.4	0.7	-0.8	-0.1
Chest pain or discomfort	0.0	0.0	0.0	0.2	0.2
Age at last live birth	0.0	0.1	0.1	-0.4	-0.1
Mood swings	0.0	0.1	0.1	0.3	0.2
Long-standing illness, disability or infirmity	0.0	0.0	0.0	0.1	-0.0
Breast cancer (self-reported)	0.0	0.0	0.0	-0.1	0.2
Age started oral contraceptive pill	0.0	0.0	0.0	-0.1	-0.1

Hub : Genes

PYDC1

Models

Trait associations