TWAS hub - QPRT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.4530	0.0540	0.0e+00	0.204	0.277	0.318	0.294	0.296	2.6e-24	8.1e-34	1.8e-39	4.6e-36	2.2e-36
2	ROSMAP	Brain Pre-frontal Cortex	0.3215	0.0517	0.0e+00	0.174	0.230	0.258	0.246	0.265	7.9e-22	3.4e-29	5.0e-33	2.4e-31	5.5e-34
3	YFS	Blood	0.0680	0.0206	2.8e-10	0.039	0.041	0.046	0.046	0.044	1.2e-12	2.8e-13	1.1e-14	7.5e-15	2.6e-14
4	TCGA	Breast Invasive Carcinoma	0.0387	0.0264	8.3e-03	0.000	0.011	0.008	NA	0.004	3.6e-01	2.2e-03	5.9e-03	NA	4.2e-02
5	TCGA	Brain Lower Grade Glioma	0.1332	0.0486	6.9e-11	0.111	0.113	0.107	NA	0.107	1.5e-12	9.9e-13	3.9e-12	NA	3.4e-12

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Friendships satisfaction	4.5	5.6	8.3	-2.9	-2.8	2.0	-1.3	-2.5
Birth weight	3.6	7.9	11.1	-3.0	-3.3	2.2	-1.9	-3.2
Ever had bowel cancer screening	3.6	4.3	6.9	-2.3	-1.9	2.4	-0.1	-2.6
Average weekly beer plus cider intake	3.5	5.1	8.2	2.8	2.4	-1.4	1.4	2.9
Number of full brothers	3.4	4.3	6.2	2.1	2.2	-2.5	-0.1	2.5
Myopia	3.2	4.6	16.1	-1.1	-1.3	1.1	-4.0	-1.6
Basal cell carcinoma (self-reported)	3.1	3.7	9.7	0.5	0.5	-2.7	-3.1	1.0
Comparative body size at age 10	3.0	8.2	20.3	-2.0	-2.2	4.5	1.6	-3.0
Pain all over the body in last month	2.8	3.0	7.1	-1.2	-1.0	2.3	2.7	-0.8
Ever highly irritable/argumentative for 2 days	2.8	3.4	6.9	-2.1	-2.6	1.3	1.2	-1.6
Alcohol usually taken with meals	2.7	4.4	6.9	-2.6	-2.4	1.1	-1.4	-2.5
Blood Platelet Count	2.5	28.4	54.8	4.7	5.5	-7.4	-4.5	3.9
Pack years adult smoking proportion	2.5	3.9	7.2	2.3	1.9	-1.6	0.8	2.7
Average weekly fortified wine intake	2.5	2.9	5.3	-2.0	-1.4	-0.2	-2.3	-1.9
Qualifications: CSEs or equivalent	2.5	3.4	7.7	2.0	1.7	-1.1	1.1	2.8
Mouth/teeth dental problems: Dentures	2.5	4.2	6.8	2.6	2.5	-0.5	1.2	2.5
Ever had hysterectomy (womb removed)	2.4	2.8	6.9	0.1	0.4	2.5	2.6	0.8
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	5.6	1.7	2.4	-2.0	-0.1	1.7
Alzheimer’s Disease (in mother)	2.2	2.6	6.7	0.7	0.9	-2.2	-2.6	-0.2
Stomach or abdominal pain in last month	2.2	2.7	4.7	1.9	2.2	-0.9	-0.1	2.2
Pack years of smoking	2.1	3.1	6.1	2.0	1.6	-1.2	1.0	2.5
Neuroticism (2016)	2.0	2.8	7.6	-1.0	-0.9	2.8	0.8	-2.1
Medication for hormone replacement therapy	2.0	2.2	3.2	-1.5	-1.6	1.7	-0.1	-1.8
Hair/balding pattern: Pattern 3	2.0	2.9	4.6	1.8	2.2	-1.5	-1.3	1.7
Average weekly red wine intake	2.0	2.9	4.4	-2.1	-2.1	1.3	-1.1	-1.7
Medication: Ramipril	1.9	2.5	5.3	1.7	1.8	-0.9	0.4	2.3
Age when periods started (menarche)	1.8	4.4	13.4	0.2	0.8	-3.7	-2.8	0.1
Family relationship satisfaction	1.8	2.2	6.6	-1.9	-2.6	-0.1	-0.5	-0.7
Smoking status: Previous	1.8	2.6	8.4	-1.1	-0.9	2.9	1.5	-0.7
Wears glasses or contact lenses	1.8	2.1	4.9	-1.2	-1.2	2.2	0.4	-1.7
Medication: Gliclazide	1.7	1.9	3.8	-1.2	-1.5	1.9	1.1	-1.0
Alcohol drinker status: Never	1.7	2.0	3.8	-1.7	-2.0	0.7	-0.7	-1.5
Fed-up feelings	1.6	2.9	4.9	2.0	2.2	-0.1	1.6	1.7
Qualifications: None of the above	1.6	3.3	8.7	1.6	1.4	1.2	3.0	1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.8	-1.7	-1.4	1.1	-1.4	-1.2
Loneliness, isolation	1.6	2.2	7.3	-0.2	-0.5	1.8	2.7	0.2
Medication: Bendroflumethiazide	1.6	2.4	4.2	-2.0	-1.9	1.1	1.3	-1.2
Lupus	1.5	2.3	3.5	1.8	1.7	-1.9	0.3	1.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.9	1.0	1.2	-0.2	2.0	1.2
Past tobacco smoking	1.5	2.7	7.8	1.0	0.7	-2.8	-2.1	0.4
Exposure to tobacco smoke outside home	1.5	2.0	2.9	1.7	1.5	-0.5	1.3	1.6
Qualifications: College or University degree	1.5	4.6	17.0	-1.0	-0.9	-1.2	-4.1	-1.7
Qualifications: nursing, teaching	1.5	2.3	6.0	-1.4	-0.8	-0.6	-2.5	-1.6
Commuting to job workplace: Walk	1.5	1.7	3.4	-1.1	-1.2	1.2	-0.9	-1.8
Townsend deprivation index at recruitment	1.4	2.0	3.2	1.8	1.8	-0.8	-0.6	1.6
Waist circumference	1.4	5.0	14.1	-0.2	-0.7	3.2	3.8	-0.2
Health satisfaction	1.4	1.9	3.7	-1.3	-1.4	1.9	1.2	-0.7
Illnesses of father: Heart disease	1.4	1.9	6.3	-0.4	-0.7	1.6	2.5	0.1
Commuting to job workplace: Cycle	1.4	1.6	4.1	-0.9	-0.6	2.0	1.7	0.0
Heart attack	1.3	1.6	3.0	1.4	1.4	-0.9	0.5	1.7
Father’s age at death	1.3	1.8	2.3	-1.5	-1.3	0.6	-1.5	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.4	1.8	1.4	0.0	0.3	1.5
Age at last live birth	1.3	1.9	3.9	-2.0	-1.5	1.2	-0.5	-1.2
Ever depressed for a whole week	1.3	1.5	3.4	-0.7	-0.8	-1.8	-1.8	-0.3
Rheumatoid Arthritis	1.2	1.6	2.5	1.5	1.6	-0.6	1.2	1.3
BMI	1.2	6.8	21.5	0.0	-0.6	3.5	4.6	-0.2
High blood pressure (mother)	1.2	1.6	3.5	1.3	1.4	-0.7	0.7	1.9
Hearing difficulty/problems with background noise	1.2	2.0	5.3	0.6	0.7	1.4	2.3	1.4
Qualifications: A levels/AS levels or equivalent	1.2	2.8	4.3	-1.7	-1.6	-0.1	-2.0	-2.1
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	3.2	1.8	1.2	-1.6	-0.9	1.2
Guilty feelings	1.2	1.9	5.5	-0.2	0.1	2.3	1.9	-0.6
HbA1C	1.1	1.2	2.6	1.3	0.9	-1.6	-0.8	0.6
Diabetes (father)	1.1	1.4	2.6	1.2	1.1	-0.0	1.4	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	4.4	1.1	1.3	0.4	2.1	1.4
Overall health rating	1.1	2.4	3.4	1.8	1.8	-1.0	1.1	1.8
Ever smoked	1.1	1.9	5.2	-0.4	-0.0	2.0	2.3	0.4
Heart disease (siblings)	1.1	1.4	2.0	-1.3	-1.4	0.6	1.0	-1.3
Ulcerative Colitis (UC)	1.0	1.9	3.0	1.7	1.4	-0.3	1.7	1.3
Fasting Glucose	1.0	1.2	1.5	-1.2	-1.0	1.0	-1.2	-1.2
Serious illness, injury or assault to yourself	1.0	1.2	4.6	-0.7	-0.4	2.1	-0.2	-1.0
Multivitamins +/- minerals	1.0	1.2	3.2	-0.9	-0.6	1.8	-0.8	-1.1
Supplements: Glucosamine	1.0	1.3	2.7	-0.9	-1.0	1.6	0.5	-1.3
Mouth/teeth dental problems	1.0	1.5	2.7	-1.6	-1.4	-1.1	-0.7	-1.0
Pulse wave reflection index	1.0	1.3	2.8	-0.8	-0.7	1.4	1.7	-0.6
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.8	-1.7	-1.1	-0.1	-1.6	-1.1
Glaucoma (self-reported)	1.0	1.2	1.8	-1.2	-1.3	0.9	-0.9	-1.0
Eye problems/disorders: Cataract	1.0	1.1	2.8	-0.7	-0.7	-1.0	-1.7	-0.9
Risk taking	1.0	1.4	2.4	1.5	0.8	-0.9	1.1	1.6
Unable to work because of sickness or disability	1.0	1.3	4.3	0.3	-0.0	1.4	2.1	0.2
Neuroticism (Nagel 2018)	0.9	2.0	6.7	0.5	1.1	1.4	2.6	0.3
Neuroticism	0.9	2.1	8.1	0.5	0.8	1.2	2.8	0.1
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.3	-0.9	-0.8	1.5	1.2	-1.0
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.1	0.5	0.5	0.8	1.7	0.8
Body mass index (BMI)	0.9	3.8	9.9	0.4	-0.3	2.9	3.2	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	-1.3	-1.0	-0.6	-1.2	-0.9
Illnesses of siblings	0.9	1.3	3.3	-0.9	-1.2	-0.3	-1.8	-1.1
Number of live births	0.9	1.3	2.3	1.3	1.2	0.7	1.5	0.7
Arm fat mass (right)	0.9	3.6	9.9	0.4	-0.3	2.8	3.1	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	-1.1	-0.7	1.5	0.7	-0.5
Average weekly champagne plus white wine intake	0.9	1.2	1.8	-1.2	-1.3	0.8	-0.7	-1.3
Arm fat-free mass (left)	0.9	4.5	8.0	-1.6	-2.1	2.8	2.7	-0.6
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.5	1.1	1.1	-0.8	0.6	1.6
Alzheimer’s Disease (including proxy)	0.8	1.2	3.3	0.4	0.6	-1.8	-1.5	-0.3
Reaction Time	0.8	1.5	3.4	-1.1	-0.7	1.3	-0.8	-1.8
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.1	0.9	1.3	-1.5	-2.0	0.1
Medication: Atenolol	0.8	1.1	2.3	-1.1	-1.0	1.5	0.5	-0.7
Number of incorrect matches in round	0.8	1.3	3.0	0.7	0.9	-1.4	-1.7	0.0
Weight	0.8	4.0	9.1	-0.7	-1.3	2.9	3.0	-0.5
Hip circumference	0.8	3.2	8.6	0.2	-0.6	2.7	2.9	0.0
Noisy workplace	0.8	1.0	2.4	0.8	0.6	-1.5	0.4	1.2
Trunk predicted mass	0.8	4.3	6.1	-1.9	-2.3	2.5	2.5	-0.7
Peak expiratory flow (PEF)	0.8	1.8	3.5	-1.9	-1.0	0.9	-1.2	-1.5
Arm fat-free mass (right)	0.8	3.9	6.4	-1.6	-2.1	2.5	2.5	-0.7
Age at first live birth	0.8	1.5	3.4	-1.9	-1.6	0.0	-0.8	-0.8
Whole body fat mass	0.8	3.2	7.8	-0.1	-0.6	2.8	2.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.8	1.3	1.5	-1.7	-1.1	0.9
Arm fat mass (left)	0.8	3.4	8.2	0.1	-0.7	2.9	2.9	-0.3
Mother’s age at death	0.8	1.0	1.6	-1.2	-1.2	1.3	0.6	-0.6
Irritability	0.8	1.4	3.4	-0.6	-0.1	1.8	1.8	-0.3
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.5	-1.2	-1.2	0.4	-0.7	-1.0
Cholesterol lowering medication	0.8	1.2	1.7	1.3	1.3	-1.3	-0.6	0.9
Arm predicted mass (left)	0.8	4.0	7.4	-1.4	-1.9	2.7	2.6	-0.5
Depressed Affect (Nagel 2018)	0.7	1.5	6.1	0.4	0.5	0.8	2.5	0.4
Age at First Birth	0.7	1.0	1.6	-1.1	-1.2	0.1	1.2	-0.8
Primary Biliary Cirrhosis	0.7	1.0	2.0	1.0	1.0	0.2	1.4	1.0
Smoking Status	0.7	1.7	4.2	-0.8	-0.8	2.1	1.7	-0.3
Lung FVC	0.7	3.6	7.6	-1.6	-1.3	-1.4	-2.8	-2.1
Diabetes (mother)	0.7	0.9	1.7	-1.0	-0.7	1.3	-0.6	-0.9
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	1.4	0.8	-0.7	0.3	0.7
Arm fat percentage (right)	0.7	2.9	7.6	0.5	-0.1	2.8	2.5	-0.1
Trunk fat-free mass	0.7	4.2	6.0	-1.8	-2.3	2.4	2.5	-0.7
Pulse rate	0.7	1.2	2.5	1.0	1.0	-1.6	-0.7	1.1
Medication: Amlodipine	0.7	1.0	2.0	-1.4	-1.4	0.0	-0.4	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.3	-1.1	-0.9	0.6	0.9	-1.2
Medication: Blood pressure	0.7	1.2	2.6	-0.8	-0.5	1.5	1.6	-0.7
Mean time to correctly identify matches	0.7	1.4	3.0	-1.0	-0.6	1.7	0.0	-1.6
Heart disease (mother)	0.7	0.8	3.4	0.4	0.4	0.1	1.8	0.7
Number of full sisters	0.7	0.9	2.4	-0.8	-0.7	1.6	-0.5	-0.8
Knee pain experienced in last month	0.7	1.1	2.4	1.4	1.6	0.4	0.8	0.6
Whole body fat-free mass	0.7	3.8	6.8	-1.4	-1.9	2.5	2.6	-0.5
Arm fat percentage (left)	0.7	2.7	6.9	0.5	-0.1	2.6	2.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.6	1.0	1.3	-0.5	0.2	1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	0.9	1.3	-1.1	-0.4	1.0
Ever taken oral contraceptive pill	0.7	0.8	3.1	-0.4	-0.2	1.8	0.9	0.2
Basal metabolic rate	0.7	3.8	7.3	-1.2	-1.8	2.6	2.7	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.1	-1.1	-0.6	1.1	-1.0	-1.0
Crohns Disease (2017)	0.6	1.4	3.3	-1.0	-0.7	1.8	1.1	-1.0
Crohns Disease (2012)	0.6	1.0	1.8	-0.6	-0.5	1.3	1.2	-1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.4	0.1	0.6	0.9	1.8	0.9
Number of treatments/medications taken	0.6	1.1	3.3	-0.6	-0.6	1.3	1.8	-0.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.1	1.0	1.0	0.7	0.9	0.7
Hearing difficulty/problems: Yes	0.6	1.0	2.1	0.5	0.8	1.0	1.4	1.0
Impedance of leg (left)	0.6	2.9	7.3	-0.2	0.2	-2.7	-2.6	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.5	0.0	0.2	1.0	1.9	0.3
Had menopause	0.6	0.7	1.8	-0.8	-0.6	1.3	0.8	-0.6
Allergy	0.6	1.4	2.5	-1.2	-1.6	0.8	1.6	-0.1
Neuroticism score	0.6	1.3	3.4	-0.1	0.2	1.6	1.9	-0.5
Depression (self-reported)	0.6	0.8	1.2	-0.9	-0.7	1.1	0.5	-1.1
Tense / ‘highly strung’	0.6	1.0	2.4	-0.4	-0.2	1.5	1.6	-0.2
Leg fat mass (right)	0.6	2.5	6.5	0.2	-0.3	2.4	2.5	0.1
Arm predicted mass (right)	0.6	3.2	6.9	-1.2	-1.7	2.2	2.6	-0.3
Leg pain on walking	0.6	0.7	2.1	0.6	0.4	-1.4	-0.9	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	-0.8	-1.5	0.0	0.2	-0.7
Whole body water mass	0.6	3.6	6.5	-1.3	-1.8	2.5	2.5	-0.5
Leg fat mass (left)	0.6	2.3	6.2	0.2	-0.4	2.3	2.5	0.1
Prostate Cancer	0.5	0.7	1.5	0.7	0.8	-0.3	0.9	1.2
Ulcerative Colitis	0.5	0.8	1.4	1.2	1.0	-1.0	-0.3	0.7
Allergy or Eczema	0.5	1.3	3.9	0.5	0.8	-1.2	-2.0	-0.3
Angina	0.5	0.7	3.0	0.2	0.1	0.6	1.7	0.2
Impedance of leg (right)	0.5	2.5	6.4	0.1	0.5	-2.5	-2.5	0.3
Leg fat-free mass (left)	0.5	2.8	6.3	-0.6	-1.1	2.5	2.5	-0.2
Hand grip strength (right)	0.5	1.4	3.8	0.6	0.4	-2.0	-0.0	1.6
Maternal smoking around birth	0.5	0.7	1.5	1.1	1.2	0.5	-0.2	0.4
Leg predicted mass (left)	0.5	2.8	6.2	-0.6	-1.1	2.5	2.5	-0.2
Trunk fat mass	0.5	2.4	5.7	-0.2	-0.8	2.4	2.3	-0.3
Hair/balding pattern: Pattern 2	0.5	0.7	1.8	0.5	0.8	-1.3	-0.6	0.6
Had other major operations	0.5	0.7	1.6	-1.0	-1.3	-0.6	0.0	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	-1.2	-0.6	0.4	-1.4	-1.4
Diabetes (self-reported)	0.5	0.8	2.3	-0.1	0.1	1.1	1.5	0.6
Happiness	0.5	0.5	0.8	-0.9	-0.9	-0.3	-0.8	-0.6
Medication: Cholesterol lowering	0.5	0.8	2.1	-0.7	-0.3	1.4	1.0	-0.4
Medication: Lansoprazole	0.5	0.5	1.6	-0.3	-0.7	1.3	0.4	-0.6
Blood clot in the leg (DVT)	0.5	0.6	1.3	-0.8	-0.4	1.1	-0.6	-0.8
Headache pain in last month	0.5	0.9	2.5	0.2	-0.0	1.6	1.2	-0.6
Leg fat percentage (right)	0.5	1.8	4.4	0.5	0.0	2.1	2.1	0.1
Shortness of breath walking on level ground	0.5	0.6	1.9	0.3	0.3	0.9	1.4	0.2
Neck or shoulder pain in last month	0.5	0.6	2.8	0.2	-0.2	0.5	1.7	0.2
Angina (self-reported)	0.5	0.7	2.9	0.2	0.1	0.5	1.7	0.4
Medication: Seretide 50 evohaler	0.5	0.6	2.3	0.1	-0.0	0.5	1.5	0.5
Alcohol intake frequency.	0.5	1.2	2.9	-0.7	-0.8	1.5	1.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	-0.4	-0.2	-1.6	-1.6	0.1
Leg fat-free mass (right)	0.5	2.5	5.5	-0.8	-1.2	2.2	2.3	-0.2
Leg predicted mass (right)	0.5	2.7	5.6	-0.9	-1.4	2.3	2.4	-0.3
Hearing aid user	0.5	0.6	0.8	0.7	0.8	0.9	0.8	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.6	0.6	1.3	-0.0	0.1	0.9
Commuting to job workplace: Public transport	0.5	0.6	1.2	-1.0	-1.1	-0.1	-0.6	-0.7
High cholesterol (Self-reported)	0.5	0.8	2.1	-0.8	-0.3	0.7	-0.9	-1.4
Leg fat percentage (left)	0.5	1.8	4.5	0.4	-0.1	2.0	2.1	0.1
Pain experienced in last month	0.5	0.8	2.0	-0.3	-0.4	-1.3	-1.4	0.2
Mean Putamen Volume	0.4	0.4	0.7	0.7	0.4	0.4	0.8	0.8
Blood Red Count	0.4	4.3	11.1	-0.4	0.8	-3.3	-2.8	1.3
Blood White Count	0.4	3.2	10.4	1.2	0.7	-3.2	-1.2	1.4
Heel T-Score	0.4	3.1	4.3	-2.1	-1.7	-0.0	-2.0	-2.0
Medication: Metformin	0.4	0.6	1.3	-0.1	-0.0	1.1	1.1	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	0.9	1.0	0.3	0.8	0.1
Nervous feelings	0.4	0.7	2.0	1.2	1.4	-0.5	-0.1	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.9	0.1	-1.0	-0.2	0.7
Prospective memory result	0.4	0.5	2.0	0.3	0.2	0.4	1.4	0.4
Lung cancer (father)	0.4	0.5	1.1	0.6	1.1	-0.4	0.4	0.9
Impedance of arm (left)	0.4	1.7	4.3	0.4	0.7	-1.9	-2.1	0.0
Body fat percentage	0.4	1.8	4.9	0.3	-0.2	2.2	1.9	-0.2
Number of children fathered	0.4	0.5	1.5	0.6	0.5	0.1	1.2	0.5
Emphysema/chronic bronchitis	0.4	0.5	1.7	0.3	0.6	1.3	0.6	0.0
Comparative height size at age 10	0.4	2.3	5.7	-1.1	-1.2	1.7	2.4	-0.5
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	-0.9	-0.6	0.9	-0.4	-0.7
Mood swings	0.4	0.8	1.3	1.0	1.1	-0.5	1.1	0.4
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.4	0.5	1.0	1.3	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.3	0.0	1.0	1.2	-0.2
Medication: Atorvastatin	0.4	0.6	2.3	0.1	0.6	0.3	-1.5	0.0
Illnesses of father: High blood pressure	0.4	0.5	2.4	0.0	-0.4	-0.1	-1.5	-0.2
Impedance of whole body	0.4	2.2	5.9	-0.0	0.4	-2.2	-2.4	-0.0
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	0.0	0.6	0.5	1.3	-0.1
Irritable Bowel Disease (IBD)	0.3	0.8	3.0	0.5	0.4	0.8	1.7	0.2
Blood Eosinophil Count	0.3	2.2	9.7	0.5	0.9	-3.1	-0.5	0.2
Waist Hip Ratio (WHR)	0.3	1.2	2.6	-0.8	-0.5	1.4	1.6	-0.5
Respiratory disease	0.3	0.6	1.3	1.2	1.1	-0.4	0.1	0.2
Tanning	0.3	3.1	10.3	0.8	0.6	-3.2	-1.8	0.9
Supplements: Zinc	0.3	0.3	0.9	-0.4	-0.5	0.2	-1.0	-0.4
Medication: Co-codamol	0.3	0.3	0.8	0.1	0.3	-0.3	0.9	0.9
Trunk fat percentage	0.3	1.4	3.7	0.3	-0.2	1.9	1.8	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.2	0.3	1.0	1.0	0.1
Relative age voice broke	0.3	0.5	1.6	-0.1	-0.3	-0.4	-1.3	-0.6
Financial difficulties in last 2 years	0.3	0.3	1.4	-0.2	-0.3	1.2	-0.0	-0.4
Medication: Simvastatin	0.3	0.5	0.8	0.6	0.8	-0.3	0.9	0.6
Impedance of arm (right)	0.3	1.4	3.4	0.3	0.6	-1.7	-1.9	0.2
Asthma	0.3	0.5	1.3	1.1	1.2	-0.3	-0.3	-0.1
Illnesses of mother	0.3	0.4	0.6	-0.7	-0.7	0.5	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	-1.1	-0.9	-1.4	-1.0	-0.4
Length of working week for main job	0.3	0.4	1.0	0.6	0.5	-0.4	0.3	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.9	-0.3	-0.3	1.0	0.6	-0.4
Breastfed as a baby	0.3	0.4	1.1	-0.7	-0.5	0.1	-1.0	-0.6
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	-0.1	-0.2	1.3	-0.5	-0.5
Medication: Paracetamol	0.3	0.5	1.4	1.0	1.2	-0.2	-0.0	0.2
Gout (self-reported)	0.3	0.4	1.0	-0.2	-0.3	0.3	-1.0	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.0	3.4	-0.5	-0.6	-1.8	-0.9	-0.2
Eye problems/disorders: None of the above	0.3	0.3	0.5	0.7	0.7	-0.0	0.5	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	-0.5	-0.7	0.7	0.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.7	0.7	0.4	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.8	0.3	0.3	-0.1	1.4	0.2
Supplements: Vitamin C	0.3	0.4	0.7	0.1	0.1	-0.8	0.9	0.7
Hypertension (Self-reported)	0.3	0.9	2.2	-1.5	-1.1	0.0	-0.4	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.1	0.1	1.3	0.7	-0.2
Asthma (self-reported)	0.3	0.5	1.0	0.9	1.0	-0.4	-0.8	-0.4
Osteoporosis (self-reported)	0.3	0.4	1.3	0.1	0.2	-0.8	-1.2	-0.2
Financial situation satisfaction	0.3	0.4	1.7	-0.0	-0.2	1.3	0.3	0.1
Medication: Paracetamol	0.3	0.5	0.9	0.6	0.8	-0.9	0.2	0.8
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.8	0.6	-0.6	-0.4	0.5
Age started oral contraceptive pill	0.3	0.3	0.5	-0.7	-0.5	-0.4	0.5	-0.7
Alcohol drinker status: Previous	0.3	0.4	1.2	-0.3	-0.3	1.1	0.7	-0.3
Depression (Nagel 2018)	0.2	0.3	0.8	-0.3	0.1	0.9	0.9	-0.0
Schizophrenia (2018)	0.2	0.4	0.9	0.3	1.0	-0.9	-0.4	0.3
Worry (Nagel 2018)	0.2	0.4	1.3	0.1	0.7	0.3	1.1	0.1
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.2	0.2	-0.2	0.9	0.3
Major Depression (MDD)	0.2	0.3	1.1	0.0	0.1	0.4	1.1	0.1
Breast Cancer	0.2	0.4	0.7	-0.6	-0.8	0.6	-0.2	-0.9
Ovarian Cancer	0.2	0.3	0.5	0.7	0.6	-0.5	-0.5	-0.1
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.4	-0.0	1.0	-0.4	-0.1
HDL Cholesterol	0.2	0.4	1.0	-0.5	-0.7	-0.6	-0.1	-1.0
LDL Cholesterol	0.2	0.3	0.8	0.5	0.7	-0.2	-0.9	0.4
Schizophrenia (2014)	0.2	0.3	0.8	-0.7	-0.4	-0.5	-0.1	-0.9
Height	0.2	3.2	6.5	-2.5	-2.3	1.7	0.7	-0.9
Cardiovascular Disease	0.2	0.6	1.2	-0.8	-0.4	0.8	1.1	-0.6
Hand grip strength (left)	0.2	0.6	2.2	0.2	-0.1	-1.5	-0.4	0.6
Average weekly spirits intake	0.2	0.3	0.6	0.2	0.3	-0.1	-0.8	0.7
Sensitivity / hurt feelings	0.2	0.3	0.7	0.5	0.8	0.7	0.1	0.0
Relative age of first facial hair	0.2	0.4	1.3	0.6	-0.0	-1.1	-0.6	0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.2	-0.3	0.0	-0.1	-1.1	-0.2
Vitamin and mineral supplements	0.2	0.2	0.5	0.1	-0.2	-0.7	0.7	0.1
Severe depression (siblings)	0.2	0.2	0.5	0.2	0.7	-0.1	0.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	-0.7	-0.2	0.9	-0.7	-0.8
High blood pressure	0.2	0.5	1.2	-1.1	-0.9	-0.0	0.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.2	-0.2	0.3	0.3	1.1	0.1
Medication: Levothyroxine sodium	0.2	0.4	1.4	0.0	-0.1	-0.1	-1.2	-0.6
Forced vital capacity (FVC)	0.2	0.8	1.7	-0.9	-0.8	-1.3	-0.9	-0.5
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.5	-0.6	0.5	0.4	-0.8
Falls in the last year	0.2	0.3	0.8	-0.4	-0.6	0.4	0.9	-0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-1.1	-0.7	-1.0	-0.7	-0.3
Standing height	0.2	2.3	5.6	-2.4	-2.2	0.2	-0.1	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	-0.7	-0.8	0.2	0.6	-0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	-1.0	-0.8	0.2	1.1	-0.2
Birth weight of first child	0.2	0.4	0.5	-0.7	-0.6	-0.3	-0.7	-0.6
Loud music exposure frequency	0.2	0.2	0.4	0.1	-0.6	-0.0	-0.5	-0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.7	0.4	-0.0	0.5	-0.1
High blood pressure (siblings)	0.2	0.3	0.6	0.3	0.7	0.5	0.6	0.1
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.0	-0.5	0.8	0.8	-0.2
Pulse wave peak to peak time	0.2	0.2	0.7	0.3	0.3	-0.3	-0.8	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.3	0.4	0.4	0.7	0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	-0.0	0.0	-0.9	-0.8	0.6
Medication: Omeprazole	0.2	0.3	0.5	0.6	0.1	-0.6	0.7	0.4
Suffer from ‘nerves’	0.2	0.4	0.8	0.3	0.9	0.3	0.9	0.1
Medication: Aspirin	0.2	0.3	0.4	-0.5	-0.5	0.6	0.7	-0.0
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.6	0.4	0.8	0.3	0.3
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.3	0.2	0.9	0.9	0.3
Back pain experienced in last month	0.2	0.3	0.4	0.5	0.6	-0.6	-0.2	0.6
Mineral and other dietary supplements	0.2	0.3	0.7	-0.1	0.1	-0.8	-0.7	0.3
Medication: Aspirin	0.2	0.3	1.1	-0.0	-0.1	0.4	1.0	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	0.7	1.0	-0.2	0.3	0.7
Miserableness	0.2	0.3	1.0	-0.3	-0.4	0.4	1.0	-0.3
Medication: Blood pressure	0.2	0.4	1.1	0.3	0.4	-0.1	1.1	0.8
Medication: Lisinopril	0.2	0.2	0.8	-0.9	-0.5	0.2	0.1	-0.4
Number of operations (self-reported)	0.2	0.3	1.1	-0.3	-0.1	0.5	1.1	0.5
Supplements: Calcium	0.2	0.2	0.3	-0.2	-0.2	0.5	-0.5	-0.5
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.6	-0.5	-0.3	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	-0.1	0.3	-0.9	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.3	0.2	0.1	-0.0	-1.2	-0.3
Triglycerides	0.1	0.2	0.3	0.6	0.4	-0.5	-0.4	0.5
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.2	-0.5	-0.2	-0.9	-0.4
Lung FEV1/FVC ratio	0.1	0.5	1.6	-1.3	-0.7	-0.3	-0.6	0.4
Chronotype (morning person)	0.1	0.3	1.0	-0.1	0.2	0.7	0.4	-1.0
Systolic blood pressure, automated reading	0.1	0.2	0.9	-0.2	-0.2	1.0	-0.0	-0.4
Taking other prescription medications	0.1	0.1	0.3	-0.3	-0.5	-0.2	-0.3	-0.5
Sitting height	0.1	0.5	0.7	-0.8	-0.8	-0.9	-0.6	0.5
Fluid intelligence score	0.1	0.3	0.6	0.1	-0.1	-0.8	-0.7	0.3
Time employed in main current job	0.1	0.1	0.3	0.1	0.3	0.5	0.1	-0.2
Worrier / anxious feelings	0.1	0.2	0.5	0.1	0.3	0.2	0.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.2	-0.1	0.6	0.2	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.5	-0.5	-0.4	0.1	0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.4	0.3	-0.3	-0.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.2	0.0	-0.3	-0.7	-0.2
Worry too long after embarrassment	0.1	0.1	0.2	0.4	0.4	-0.0	0.1	0.2
Migraine (self-reported)	0.1	0.1	0.3	0.4	0.2	0.2	-0.5	-0.2
Medication: Ibuprofen	0.1	0.1	0.2	0.3	0.3	-0.4	0.4	0.5
Pulse rate, automated reading	0.1	0.5	1.9	-0.2	-0.1	-1.4	-0.5	0.2
Had major operations	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.2	0.6
Medication for cholesterol	0.1	0.1	0.1	0.3	0.4	-0.2	-0.3	0.3
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.5	0.4	0.2	-0.4	-0.6
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	0.1	0.1	0.1	0.5	0.7
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.3	-0.4	-0.1	-0.5	0.2
Diastolic blood pressure, automated reading	0.1	0.4	0.9	-0.7	-1.0	0.7	-0.2	-0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	0.6	0.5	0.4	-0.6	0.1
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.6	0.2	-0.1	0.6	0.1
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.1	-0.1	-0.4	-0.1	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.0	0.1	0.4	0.3	0.3	0.1	0.0	0.6
Hair Pigment	0.0	1.0	1.7	1.2	1.3	-0.2	0.4	1.2
Current tobacco smoking	0.0	0.1	0.1	0.2	0.2	-0.1	0.4	0.2
Medication: Allopurinol	0.0	0.0	0.1	0.2	0.0	0.1	-0.0	-0.1
Chest pain or discomfort	0.0	0.0	0.1	-0.0	0.0	0.1	-0.0	0.3
Breast cancer (self-reported)	0.0	0.0	0.1	0.1	0.0	0.3	0.1	0.0
Smoking status: Current	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3	-0.1

Hub : Genes

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Trait associations