Hub : Genes

QPRT

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.4530	0.0540	0.0e+00	0.204	0.277	0.318	0.294	0.296	2.6e-24	8.1e-34	1.8e-39	4.6e-36	2.2e-36
2	ROSMAP	Brain Pre-frontal Cortex	0.3215	0.0517	0.0e+00	0.174	0.230	0.258	0.246	0.265	7.9e-22	3.4e-29	5.0e-33	2.4e-31	5.5e-34
3	YFS	Blood	0.0680	0.0206	2.8e-10	0.039	0.041	0.046	0.046	0.044	1.2e-12	2.8e-13	1.1e-14	7.5e-15	2.6e-14
4	TCGA	Breast Invasive Carcinoma	0.0387	0.0264	8.3e-03	0.000	0.011	0.008	NA	0.004	3.6e-01	2.2e-03	5.9e-03	NA	4.2e-02
5	TCGA	Brain Lower Grade Glioma	0.1332	0.0486	6.9e-11	0.111	0.113	0.107	NA	0.107	1.5e-12	9.9e-13	3.9e-12	NA	3.4e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.3	-0.6	-0.5	-0.3	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	-0.1	0.3	-0.9	0.0	0.0
Depressed Affect (Nagel 2018)	0.7	1.5	6.1	0.4	0.5	0.8	2.5	0.4
Depression (Nagel 2018)	0.2	0.3	0.8	-0.3	0.1	0.9	0.9	-0.0
Intelligence (Savage-Jansen 2018)	0.1	0.3	1.3	0.2	0.1	-0.0	-1.2	-0.3
Neuroticism (Nagel 2018)	0.9	2.0	6.7	0.5	1.1	1.4	2.6	0.3
Schizophrenia (2018)	0.2	0.4	0.9	0.3	1.0	-0.9	-0.4	0.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	0.0	0.6	0.5	1.3	-0.1
Worry (Nagel 2018)	0.2	0.4	1.3	0.1	0.7	0.3	1.1	0.1
Alzheimer’s Disease (in mother)	2.2	2.6	6.7	0.7	0.9	-2.2	-2.6	-0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.2	0.2	-0.2	0.9	0.3
Alzheimer’s Disease (including proxy)	0.8	1.2	3.3	0.4	0.6	-1.8	-1.5	-0.3
Crohns Disease (2017)	0.6	1.4	3.3	-1.0	-0.7	1.8	1.1	-1.0
Irritable Bowel Disease (IBD)	0.3	0.8	3.0	0.5	0.4	0.8	1.7	0.2
Ulcerative Colitis (UC)	1.0	1.9	3.0	1.7	1.4	-0.3	1.7	1.3
Major Depression (MDD)	0.2	0.3	1.1	0.0	0.1	0.4	1.1	0.1
Reaction Time	0.8	1.5	3.4	-1.1	-0.7	1.3	-0.8	-1.8
Verbal and Numeric Reasoning (VNR)	0.0	0.0	0.1	-0.1	-0.1	-0.4	-0.1	0.1
Breast Cancer	0.2	0.4	0.7	-0.6	-0.8	0.6	-0.2	-0.9
Ovarian Cancer	0.2	0.3	0.5	0.7	0.6	-0.5	-0.5	-0.1
Prostate Cancer	0.5	0.7	1.5	0.7	0.8	-0.3	0.9	1.2
Age at First Birth	0.7	1.0	1.6	-1.1	-1.2	0.1	1.2	-0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.2	0.3	0.9	-0.4	-0.0	1.0	-0.4	-0.1
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.6	1.0	1.8	-0.6	-0.5	1.3	1.2	-1.0
Mean Putamen Volume	0.4	0.4	0.7	0.7	0.4	0.4	0.8	0.8
Fasting Glucose	1.0	1.2	1.5	-1.2	-1.0	1.0	-1.2	-1.2
HbA1C	1.1	1.2	2.6	1.3	0.9	-1.6	-0.8	0.6
HDL Cholesterol	0.2	0.4	1.0	-0.5	-0.7	-0.6	-0.1	-1.0
LDL Cholesterol	0.2	0.3	0.8	0.5	0.7	-0.2	-0.9	0.4
Lupus	1.5	2.3	3.5	1.8	1.7	-1.9	0.3	1.4
Neuroticism (2016)	2.0	2.8	7.6	-1.0	-0.9	2.8	0.8	-2.1
Primary Biliary Cirrhosis	0.7	1.0	2.0	1.0	1.0	0.2	1.4	1.0
Rheumatoid Arthritis	1.2	1.6	2.5	1.5	1.6	-0.6	1.2	1.3
Schizophrenia (2014)	0.2	0.3	0.8	-0.7	-0.4	-0.5	-0.1	-0.9
Triglycerides	0.1	0.2	0.3	0.6	0.4	-0.5	-0.4	0.5
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.5	0.8	1.4	1.2	1.0	-1.0	-0.3	0.7
Blood Eosinophil Count	0.3	2.2	9.7	0.5	0.9	-3.1	-0.5	0.2
Blood Platelet Count	2.5	28.4	54.8	4.7	5.5	-7.4	-4.5	3.9
Blood Red Count	0.4	4.3	11.1	-0.4	0.8	-3.3	-2.8	1.3
Blood White Count	0.4	3.2	10.4	1.2	0.7	-3.2	-1.2	1.4
Heel T-Score	0.4	3.1	4.3	-2.1	-1.7	-0.0	-2.0	-2.0
BMI	1.2	6.8	21.5	0.0	-0.6	3.5	4.6	-0.2
Height	0.2	3.2	6.5	-2.5	-2.3	1.7	0.7	-0.9
Waist Hip Ratio (WHR)	0.3	1.2	2.6	-0.8	-0.5	1.4	1.6	-0.5
Systolic Blood Pressure	0.0	0.1	0.4	0.3	0.3	0.1	0.0	0.6
Smoking Status	0.7	1.7	4.2	-0.8	-0.8	2.1	1.7	-0.3
Allergy or Eczema	0.5	1.3	3.9	0.5	0.8	-1.2	-2.0	-0.3
Cardiovascular Disease	0.2	0.6	1.2	-0.8	-0.4	0.8	1.1	-0.6
Hypothyroidism (self reported)	0.1	0.2	0.7	-0.2	-0.5	-0.2	-0.9	-0.4
Respiratory disease	0.3	0.6	1.3	1.2	1.1	-0.4	0.1	0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.4	0.1	0.6	0.9	1.8	0.9
Lung FEV1/FVC ratio	0.1	0.5	1.6	-1.3	-0.7	-0.3	-0.6	0.4
Lung FVC	0.7	3.6	7.6	-1.6	-1.3	-1.4	-2.8	-2.1
Neuroticism	0.9	2.1	8.1	0.5	0.8	1.2	2.8	0.1
Chronotype (morning person)	0.1	0.3	1.0	-0.1	0.2	0.7	0.4	-1.0
Hair Pigment	0.0	1.0	1.7	1.2	1.3	-0.2	0.4	1.2
Tanning	0.3	3.1	10.3	0.8	0.6	-3.2	-1.8	0.9
Hand grip strength (left)	0.2	0.6	2.2	0.2	-0.1	-1.5	-0.4	0.6
Number of treatments/medications taken	0.6	1.1	3.3	-0.6	-0.6	1.3	1.8	-0.2
Average weekly spirits intake	0.2	0.3	0.6	0.2	0.3	-0.1	-0.8	0.7
Sensitivity / hurt feelings	0.2	0.3	0.7	0.5	0.8	0.7	0.1	0.0
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.1	1.0	1.0	0.7	0.9	0.7
Hearing difficulty/problems: Yes	0.6	1.0	2.1	0.5	0.8	1.0	1.4	1.0
Relative age of first facial hair	0.2	0.4	1.3	0.6	-0.0	-1.1	-0.6	0.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.2	-0.3	0.0	-0.1	-1.1	-0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.3	-0.9	-0.8	1.5	1.2	-1.0
Ever had hysterectomy (womb removed)	2.4	2.8	6.9	0.1	0.4	2.5	2.6	0.8
Systolic blood pressure, automated reading	0.1	0.2	0.9	-0.2	-0.2	1.0	-0.0	-0.4
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	3.9	1.0	1.2	-0.2	2.0	1.2
Angina	0.5	0.7	3.0	0.2	0.1	0.6	1.7	0.2
Medication for hormone replacement therapy	2.0	2.2	3.2	-1.5	-1.6	1.7	-0.1	-1.8
Vitamin and mineral supplements	0.2	0.2	0.5	0.1	-0.2	-0.7	0.7	0.1
Supplements: Zinc	0.3	0.3	0.9	-0.4	-0.5	0.2	-1.0	-0.4
Medication: Co-codamol	0.3	0.3	0.8	0.1	0.3	-0.3	0.9	0.9
Medication: Metformin	0.4	0.6	1.3	-0.1	-0.0	1.1	1.1	0.5
Diabetes (father)	1.1	1.4	2.6	1.2	1.1	-0.0	1.4	1.6
Diabetes (mother)	0.7	0.9	1.7	-1.0	-0.7	1.3	-0.6	-0.9
Severe depression (siblings)	0.2	0.2	0.5	0.2	0.7	-0.1	0.5	-0.2
Pack years adult smoking proportion	2.5	3.9	7.2	2.3	1.9	-1.6	0.8	2.7
Impedance of leg (right)	0.5	2.5	6.4	0.1	0.5	-2.5	-2.5	0.3
Leg fat-free mass (left)	0.5	2.8	6.3	-0.6	-1.1	2.5	2.5	-0.2
Trunk fat percentage	0.3	1.4	3.7	0.3	-0.2	1.9	1.8	-0.1
Hand grip strength (right)	0.5	1.4	3.8	0.6	0.4	-2.0	-0.0	1.6
Townsend deprivation index at recruitment	1.4	2.0	3.2	1.8	1.8	-0.8	-0.6	1.6
Current tobacco smoking	0.0	0.1	0.1	0.2	0.2	-0.1	0.4	0.2
Average weekly fortified wine intake	2.5	2.9	5.3	-2.0	-1.4	-0.2	-2.3	-1.9
Maternal smoking around birth	0.5	0.7	1.5	1.1	1.2	0.5	-0.2	0.4
Fed-up feelings	1.6	2.9	4.9	2.0	2.2	-0.1	1.6	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.2	0.3	1.0	1.0	0.1
Relative age voice broke	0.3	0.5	1.6	-0.1	-0.3	-0.4	-1.3	-0.6
Taking other prescription medications	0.1	0.1	0.3	-0.3	-0.5	-0.2	-0.3	-0.5
Age when periods started (menarche)	1.8	4.4	13.4	0.2	0.8	-3.7	-2.8	0.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	3.1	0.5	0.5	0.8	1.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.8	-0.7	-0.2	0.9	-0.7	-0.8
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.8	1.4	0.8	-0.7	0.3	0.7
Qualifications: CSEs or equivalent	2.5	3.4	7.7	2.0	1.7	-1.1	1.1	2.8
Serious illness, injury or assault to yourself	1.0	1.2	4.6	-0.7	-0.4	2.1	-0.2	-1.0
High blood pressure	0.2	0.5	1.2	-1.1	-0.9	-0.0	0.1	-0.6
Hayfever, allergic rhinitis or eczema	0.8	1.7	4.1	0.9	1.3	-1.5	-2.0	0.1
Multivitamins +/- minerals	1.0	1.2	3.2	-0.9	-0.6	1.8	-0.8	-1.1
Stomach or abdominal pain in last month	2.2	2.7	4.7	1.9	2.2	-0.9	-0.1	2.2
Supplements: Glucosamine	1.0	1.3	2.7	-0.9	-1.0	1.6	0.5	-1.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.2	-0.2	0.3	0.3	1.1	0.1
Medication: Atenolol	0.8	1.1	2.3	-1.1	-1.0	1.5	0.5	-0.7
Medication: Levothyroxine sodium	0.2	0.4	1.4	0.0	-0.1	-0.1	-1.2	-0.6
Sitting height	0.1	0.5	0.7	-0.8	-0.8	-0.9	-0.6	0.5
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	0.9	1.0	0.3	0.8	0.1
High blood pressure (mother)	1.2	1.6	3.5	1.3	1.4	-0.7	0.7	1.9
Body mass index (BMI)	0.9	3.8	9.9	0.4	-0.3	2.9	3.2	-0.1
Impedance of leg (left)	0.6	2.9	7.3	-0.2	0.2	-2.7	-2.6	0.1
Leg predicted mass (left)	0.5	2.8	6.2	-0.6	-1.1	2.5	2.5	-0.2
Trunk fat mass	0.5	2.4	5.7	-0.2	-0.8	2.4	2.3	-0.3
Waist circumference	1.4	5.0	14.1	-0.2	-0.7	3.2	3.8	-0.2
Number of incorrect matches in round	0.8	1.3	3.0	0.7	0.9	-1.4	-1.7	0.0
Past tobacco smoking	1.5	2.7	7.8	1.0	0.7	-2.8	-2.1	0.4
Alcohol usually taken with meals	2.7	4.4	6.9	-2.6	-2.4	1.1	-1.4	-2.5
Nervous feelings	0.4	0.7	2.0	1.2	1.4	-0.5	-0.1	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.5	0.0	0.2	1.0	1.9	0.3
Hearing difficulty/problems with background noise	1.2	2.0	5.3	0.6	0.7	1.4	2.3	1.4
Hair/balding pattern: Pattern 2	0.5	0.7	1.8	0.5	0.8	-1.3	-0.6	0.6
Had menopause	0.6	0.7	1.8	-0.8	-0.6	1.3	0.8	-0.6
Had other major operations	0.5	0.7	1.6	-1.0	-1.3	-0.6	0.0	-0.6
Forced vital capacity (FVC)	0.2	0.8	1.7	-0.9	-0.8	-1.3	-0.9	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	1.9	-1.2	-0.6	0.4	-1.4	-1.4
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.7	-1.3	-1.0	-0.6	-1.2	-0.9
Qualifications: None of the above	1.6	3.3	8.7	1.6	1.4	1.2	3.0	1.5
Financial difficulties in last 2 years	0.3	0.3	1.4	-0.2	-0.3	1.2	-0.0	-0.4
Mouth/teeth dental problems	1.0	1.5	2.7	-1.6	-1.4	-1.1	-0.7	-1.0
Heart attack	1.3	1.6	3.0	1.4	1.4	-0.9	0.5	1.7
Allergy	0.6	1.4	2.5	-1.2	-1.6	0.8	1.6	-0.1
Pain all over the body in last month	2.8	3.0	7.1	-1.2	-1.0	2.3	2.7	-0.8
Diabetes (self-reported)	0.5	0.8	2.3	-0.1	0.1	1.1	1.5	0.6
Hayfever/allergic rhinitis (self-reported)	2.3	3.1	5.6	1.7	2.4	-2.0	-0.1	1.7
Medication: Ramipril	1.9	2.5	5.3	1.7	1.8	-0.9	0.4	2.3
Medication: Simvastatin	0.3	0.5	0.8	0.6	0.8	-0.3	0.9	0.6
Fluid intelligence score	0.1	0.3	0.6	0.1	-0.1	-0.8	-0.7	0.3
Illnesses of siblings	0.9	1.3	3.3	-0.9	-1.2	-0.3	-1.8	-1.1
Neuroticism score	0.6	1.3	3.4	-0.1	0.2	1.6	1.9	-0.5
Weight	0.8	4.0	9.1	-0.7	-1.3	2.9	3.0	-0.5
Impedance of arm (right)	0.3	1.4	3.4	0.3	0.6	-1.7	-1.9	0.2
Arm fat percentage (right)	0.7	2.9	7.6	0.5	-0.1	2.8	2.5	-0.1
Trunk fat-free mass	0.7	4.2	6.0	-1.8	-2.3	2.4	2.5	-0.7
Hip circumference	0.8	3.2	8.6	0.2	-0.6	2.7	2.9	0.0
Time employed in main current job	0.1	0.1	0.3	0.1	0.3	0.5	0.1	-0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.6	-0.5	-0.6	0.5	0.4	-0.8
Father’s age at death	1.3	1.8	2.3	-1.5	-1.3	0.6	-1.5	-1.5
Worrier / anxious feelings	0.1	0.2	0.5	0.1	0.3	0.2	0.4	-0.7
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.9	4.4	1.1	1.3	0.4	2.1	1.4
Falls in the last year	0.2	0.3	0.8	-0.4	-0.6	0.4	0.9	-0.2
Hair/balding pattern: Pattern 3	2.0	2.9	4.6	1.8	2.2	-1.5	-1.3	1.7
Number of live births	0.9	1.3	2.3	1.3	1.2	0.7	1.5	0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-1.1	-0.7	-1.0	-0.7	-0.3
Pulse rate	0.7	1.2	2.5	1.0	1.0	-1.6	-0.7	1.1
Happiness	0.5	0.5	0.8	-0.9	-0.9	-0.3	-0.8	-0.6
Noisy workplace	0.8	1.0	2.4	0.8	0.6	-1.5	0.4	1.2
Qualifications: A levels/AS levels or equivalent	1.2	2.8	4.3	-1.7	-1.6	-0.1	-2.0	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.9	0.9	0.1	-1.0	-0.2	0.7
Mouth/teeth dental problems: Dentures	2.5	4.2	6.8	2.6	2.5	-0.5	1.2	2.5
Asthma	0.3	0.5	1.3	1.1	1.2	-0.3	-0.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.2	-0.1	0.6	0.2	-0.4
Medication: Cholesterol lowering	0.5	0.8	2.1	-0.7	-0.3	1.4	1.0	-0.4
Depression (self-reported)	0.6	0.8	1.2	-0.9	-0.7	1.1	0.5	-1.1
Medication: Lansoprazole	0.5	0.5	1.6	-0.3	-0.7	1.3	0.4	-0.6
Prospective memory result	0.4	0.5	2.0	0.3	0.2	0.4	1.4	0.4
Lung cancer (father)	0.4	0.5	1.1	0.6	1.1	-0.4	0.4	0.9
Illnesses of mother	0.3	0.4	0.6	-0.7	-0.7	0.5	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.0	-1.1	-0.9	-1.4	-1.0	-0.4
Pulse wave Arterial Stiffness index	0.1	0.2	0.5	-0.5	-0.4	0.1	0.7	0.1
Impedance of arm (left)	0.4	1.7	4.3	0.4	0.7	-1.9	-2.1	0.0
Arm fat mass (right)	0.9	3.6	9.9	0.4	-0.3	2.8	3.1	0.1
Trunk predicted mass	0.8	4.3	6.1	-1.9	-2.3	2.5	2.5	-0.7
Standing height	0.2	2.3	5.6	-2.4	-2.2	0.2	-0.1	-0.9
Length of working week for main job	0.3	0.4	1.0	0.6	0.5	-0.4	0.3	1.0
Exposure to tobacco smoke at home	0.3	0.3	0.9	-0.3	-0.3	1.0	0.6	-0.4
Breastfed as a baby	0.3	0.4	1.1	-0.7	-0.5	0.1	-1.0	-0.6
Tense / ‘highly strung’	0.6	1.0	2.4	-0.4	-0.2	1.5	1.6	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.6	-0.7	-0.8	0.2	0.6	-0.6
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	-1.0	-0.8	0.2	1.1	-0.2
Birth weight of first child	0.2	0.4	0.5	-0.7	-0.6	-0.3	-0.7	-0.6
Peak expiratory flow (PEF)	0.8	1.8	3.5	-1.9	-1.0	0.9	-1.2	-1.5
Pulse wave reflection index	1.0	1.3	2.8	-0.8	-0.7	1.4	1.7	-0.6
Ever highly irritable/argumentative for 2 days	2.8	3.4	6.9	-2.1	-2.6	1.3	1.2	-1.6
Loud music exposure frequency	0.2	0.2	0.4	0.1	-0.6	-0.0	-0.5	-0.7
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	2.8	-1.7	-1.1	-0.1	-1.6	-1.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.6	-0.1	-0.2	1.3	-0.5	-0.5
Blood clot in the leg (DVT)	0.5	0.6	1.3	-0.8	-0.4	1.1	-0.6	-0.8
Medication: Paracetamol	0.3	0.5	1.4	1.0	1.2	-0.2	-0.0	0.2
Headache pain in last month	0.5	0.9	2.5	0.2	-0.0	1.6	1.2	-0.6
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	3.2	1.8	1.2	-1.6	-0.9	1.2
Glaucoma (self-reported)	1.0	1.2	1.8	-1.2	-1.3	0.9	-0.9	-1.0
Gout (self-reported)	0.3	0.4	1.0	-0.2	-0.3	0.3	-1.0	-0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.4	0.3	-0.3	-0.6	-0.1
Medication: Amlodipine	0.7	1.0	2.0	-1.4	-1.4	0.0	-0.4	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.2	0.0	-0.3	-0.7	-0.2
Birth weight	3.6	7.9	11.1	-3.0	-3.3	2.2	-1.9	-3.2
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.7	0.4	-0.0	0.5	-0.1
High blood pressure (siblings)	0.2	0.3	0.6	0.3	0.7	0.5	0.6	0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	3.4	-0.5	-0.6	-1.8	-0.9	-0.2
Body fat percentage	0.4	1.8	4.9	0.3	-0.2	2.2	1.9	-0.2
Leg fat percentage (right)	0.5	1.8	4.4	0.5	0.0	2.1	2.1	0.1
Arm fat-free mass (right)	0.8	3.9	6.4	-1.6	-2.1	2.5	2.5	-0.7
Exposure to tobacco smoke outside home	1.5	2.0	2.9	1.7	1.5	-0.5	1.3	1.6
Comparative body size at age 10	3.0	8.2	20.3	-2.0	-2.2	4.5	1.6	-3.0
Number of full brothers	3.4	4.3	6.2	2.1	2.2	-2.5	-0.1	2.5
Worry too long after embarrassment	0.1	0.1	0.2	0.4	0.4	-0.0	0.1	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.3	-1.1	-0.9	0.6	0.9	-1.2
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	0.0	-0.5	0.8	0.8	-0.2
Number of children fathered	0.4	0.5	1.5	0.6	0.5	0.1	1.2	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.6	1.9	2.8	-1.7	-1.4	1.1	-1.4	-1.2
Age at first live birth	0.8	1.5	3.4	-1.9	-1.6	0.0	-0.8	-0.8
Pulse wave peak to peak time	0.2	0.2	0.7	0.3	0.3	-0.3	-0.8	-0.1
Health satisfaction	1.4	1.9	3.7	-1.3	-1.4	1.9	1.2	-0.7
Shortness of breath walking on level ground	0.5	0.6	1.9	0.3	0.3	0.9	1.4	0.2
Qualifications: College or University degree	1.5	4.6	17.0	-1.0	-0.9	-1.2	-4.1	-1.7
Eye problems/disorders: None of the above	0.3	0.3	0.5	0.7	0.7	-0.0	0.5	0.7
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.3	0.4	0.4	0.7	0.1
Emphysema/chronic bronchitis	0.4	0.5	1.7	0.3	0.6	1.3	0.6	0.0
Medication for pain relief, constipation, heartburn	0.2	0.4	0.8	-0.0	0.0	-0.9	-0.8	0.6
Neck or shoulder pain in last month	0.5	0.6	2.8	0.2	-0.2	0.5	1.7	0.2
Medication: Blood pressure	0.7	1.2	2.6	-0.8	-0.5	1.5	1.6	-0.7
Angina (self-reported)	0.5	0.7	2.9	0.2	0.1	0.5	1.7	0.4
Migraine (self-reported)	0.1	0.1	0.3	0.4	0.2	0.2	-0.5	-0.2
Medication: Ibuprofen	0.1	0.1	0.2	0.3	0.3	-0.4	0.4	0.5
Medication: Allopurinol	0.0	0.0	0.1	0.2	0.0	0.1	-0.0	-0.1
Medication: Omeprazole	0.2	0.3	0.5	0.6	0.1	-0.6	0.7	0.4
Medication: Seretide 50 evohaler	0.5	0.6	2.3	0.1	-0.0	0.5	1.5	0.5
Mean time to correctly identify matches	0.7	1.4	3.0	-1.0	-0.6	1.7	0.0	-1.6
Heart disease (mother)	0.7	0.8	3.4	0.4	0.4	0.1	1.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.4	1.8	1.4	0.0	0.3	1.5
Whole body fat mass	0.8	3.2	7.8	-0.1	-0.6	2.8	2.8	-0.2
Leg fat mass (right)	0.6	2.5	6.5	0.2	-0.3	2.4	2.5	0.1
Arm predicted mass (right)	0.6	3.2	6.9	-1.2	-1.7	2.2	2.6	-0.3
Pulse rate, automated reading	0.1	0.5	1.9	-0.2	-0.1	-1.4	-0.5	0.2
Alcohol intake frequency.	0.5	1.2	2.9	-0.7	-0.8	1.5	1.7	-0.3
Comparative height size at age 10	0.4	2.3	5.7	-1.1	-1.2	1.7	2.4	-0.5
Number of full sisters	0.7	0.9	2.4	-0.8	-0.7	1.6	-0.5	-0.8
Suffer from ‘nerves’	0.2	0.4	0.8	0.3	0.9	0.3	0.9	0.1
Overall health rating	1.1	2.4	3.4	1.8	1.8	-1.0	1.1	1.8
Chest pain or discomfort	0.0	0.0	0.1	-0.0	0.0	0.1	-0.0	0.3
Had major operations	0.1	0.1	0.3	-0.3	-0.3	-0.2	-0.2	0.6
Age at last live birth	1.3	1.9	3.9	-2.0	-1.5	1.2	-0.5	-1.2
Family relationship satisfaction	1.8	2.2	6.6	-1.9	-2.6	-0.1	-0.5	-0.7
Leg pain on walking	0.6	0.7	2.1	0.6	0.4	-1.4	-0.9	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.5	-0.5	-0.7	0.7	0.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	0.7	0.7	0.4	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.8	0.3	0.3	-0.1	1.4	0.2
Medication: Aspirin	0.2	0.3	0.4	-0.5	-0.5	0.6	0.7	-0.0
Supplements: Vitamin C	0.3	0.4	0.7	0.1	0.1	-0.8	0.9	0.7
Knee pain experienced in last month	0.7	1.1	2.4	1.4	1.6	0.4	0.8	0.6
Hypertension (Self-reported)	0.3	0.9	2.2	-1.5	-1.1	0.0	-0.4	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.3	-0.8	-1.5	0.0	0.2	-0.7
Illnesses of father: Heart disease	1.4	1.9	6.3	-0.4	-0.7	1.6	2.5	0.1
Illnesses of siblings: Diabetes	0.2	0.3	0.7	0.6	0.4	0.8	0.3	0.3
Smoking status: Previous	1.8	2.6	8.4	-1.1	-0.9	2.9	1.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.7	-0.4	-0.2	-1.6	-1.6	0.1
Whole body fat-free mass	0.7	3.8	6.8	-1.4	-1.9	2.5	2.6	-0.5
Leg fat-free mass (right)	0.5	2.5	5.5	-0.8	-1.2	2.2	2.3	-0.2
Arm fat percentage (left)	0.7	2.7	6.9	0.5	-0.1	2.6	2.5	-0.2
Average weekly red wine intake	2.0	2.9	4.4	-2.1	-2.1	1.3	-1.1	-1.7
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.8	-0.9	-0.6	0.9	-0.4	-0.7
Mood swings	0.4	0.8	1.3	1.0	1.1	-0.5	1.1	0.4
Loneliness, isolation	1.6	2.2	7.3	-0.2	-0.5	1.8	2.7	0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.4	0.5	1.0	1.3	0.5
Ever had bowel cancer screening	3.6	4.3	6.9	-2.3	-1.9	2.4	-0.1	-2.6
Diabetes diagnosed by doctor	0.2	0.4	0.9	-0.3	0.2	0.9	0.9	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	2.3	-1.1	-0.7	1.5	0.7	-0.5
Friendships satisfaction	4.5	5.6	8.3	-2.9	-2.8	2.0	-1.3	-2.5
Qualifications: nursing, teaching	1.5	2.3	6.0	-1.4	-0.8	-0.6	-2.5	-1.6
Commuting to job workplace: Walk	1.5	1.7	3.4	-1.1	-1.2	1.2	-0.9	-1.8
Eye problems/disorders: Cataract	1.0	1.1	2.8	-0.7	-0.7	-1.0	-1.7	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.7	-0.1	0.1	1.3	0.7	-0.2
Medication for cholesterol	0.1	0.1	0.1	0.3	0.4	-0.2	-0.3	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	1.6	1.0	1.3	-0.5	0.2	1.1
Back pain experienced in last month	0.2	0.3	0.4	0.5	0.6	-0.6	-0.2	0.6
Mineral and other dietary supplements	0.2	0.3	0.7	-0.1	0.1	-0.8	-0.7	0.3
Breast cancer (self-reported)	0.0	0.0	0.1	0.1	0.0	0.3	0.1	0.0
Asthma (self-reported)	0.3	0.5	1.0	0.9	1.0	-0.4	-0.8	-0.4
Osteoporosis (self-reported)	0.3	0.4	1.3	0.1	0.2	-0.8	-1.2	-0.2
Osteoarthritis (self-reported)	0.1	0.2	0.3	0.5	0.4	0.2	-0.4	-0.6
Medication: Aspirin	0.2	0.3	1.1	-0.0	-0.1	0.4	1.0	0.4
Medication: Gliclazide	1.7	1.9	3.8	-1.2	-1.5	1.9	1.1	-1.0
Illnesses of father: None of the above (group 1)	0.7	0.9	1.6	0.9	1.3	-1.1	-0.4	1.0
Smoking status: Current	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	2.8	1.3	1.5	-1.7	-1.1	0.9
Whole body water mass	0.6	3.6	6.5	-1.3	-1.8	2.5	2.5	-0.5
Leg predicted mass (right)	0.5	2.7	5.6	-0.9	-1.4	2.3	2.4	-0.3
Arm fat mass (left)	0.8	3.4	8.2	0.1	-0.7	2.9	2.9	-0.3
Number of self-reported non-cancer illnesses	0.2	0.4	1.0	0.7	1.0	-0.2	0.3	0.7
Average weekly champagne plus white wine intake	0.9	1.2	1.8	-1.2	-1.3	0.8	-0.7	-1.3
Miserableness	0.2	0.3	1.0	-0.3	-0.4	0.4	1.0	-0.3
Guilty feelings	1.2	1.9	5.5	-0.2	0.1	2.3	1.9	-0.6
Wears glasses or contact lenses	1.8	2.1	4.9	-1.2	-1.2	2.2	0.4	-1.7
Ever taken oral contraceptive pill	0.7	0.8	3.1	-0.4	-0.2	1.8	0.9	0.2
Hearing aid user	0.5	0.6	0.8	0.7	0.8	0.9	0.8	0.4
Mother’s age at death	0.8	1.0	1.6	-1.2	-1.2	1.3	0.6	-0.6
Financial situation satisfaction	0.3	0.4	1.7	-0.0	-0.2	1.3	0.3	0.1
Tinnitus: Yes, now most or all of the time	0.5	0.5	1.6	0.6	1.3	-0.0	0.1	0.9
Commuting to job workplace: Public transport	0.5	0.6	1.2	-1.0	-1.1	-0.1	-0.6	-0.7
Eye problems/disorders: Glaucoma	0.1	0.1	0.5	0.1	0.1	0.1	0.5	0.7
Medication: Blood pressure	0.2	0.4	1.1	0.3	0.4	-0.1	1.1	0.8
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.3	-0.4	-0.1	-0.5	0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	0.3	0.0	1.0	1.2	-0.2
High cholesterol (Self-reported)	0.5	0.8	2.1	-0.8	-0.3	0.7	-0.9	-1.4
Medication: Bendroflumethiazide	1.6	2.4	4.2	-2.0	-1.9	1.1	1.3	-1.2
Medication: Paracetamol	0.3	0.5	0.9	0.6	0.8	-0.9	0.2	0.8
Medication: Lisinopril	0.2	0.2	0.8	-0.9	-0.5	0.2	0.1	-0.4
Medication: Atorvastatin	0.4	0.6	2.3	0.1	0.6	0.3	-1.5	0.0
Illnesses of father: High blood pressure	0.4	0.5	2.4	0.0	-0.4	-0.1	-1.5	-0.2
Alcohol drinker status: Never	1.7	2.0	3.8	-1.7	-2.0	0.7	-0.7	-1.5
Ever smoked	1.1	1.9	5.2	-0.4	-0.0	2.0	2.3	0.4
Basal metabolic rate	0.7	3.8	7.3	-1.2	-1.8	2.6	2.7	-0.5
Leg fat percentage (left)	0.5	1.8	4.5	0.4	-0.1	2.0	2.1	0.1
Arm fat-free mass (left)	0.9	4.5	8.0	-1.6	-2.1	2.8	2.7	-0.6
Number of operations (self-reported)	0.2	0.3	1.1	-0.3	-0.1	0.5	1.1	0.5
Average weekly beer plus cider intake	3.5	5.1	8.2	2.8	2.4	-1.4	1.4	2.9
Irritability	0.8	1.4	3.4	-0.6	-0.1	1.8	1.8	-0.3
Risk taking	1.0	1.4	2.4	1.5	0.8	-0.9	1.1	1.6
Ever had prostate specific antigen (PSA) test	0.8	1.0	1.5	-1.2	-1.2	0.4	-0.7	-1.0
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.8	0.6	-0.6	-0.4	0.5
Age started oral contraceptive pill	0.3	0.3	0.5	-0.7	-0.5	-0.4	0.5	-0.7
Diastolic blood pressure, automated reading	0.1	0.4	0.9	-0.7	-1.0	0.7	-0.2	-0.3
Ever depressed for a whole week	1.3	1.5	3.4	-0.7	-0.8	-1.8	-1.8	-0.3
Unable to work because of sickness or disability	1.0	1.3	4.3	0.3	-0.0	1.4	2.1	0.2
Commuting to job workplace: Cycle	1.4	1.6	4.1	-0.9	-0.6	2.0	1.7	0.0
Myopia	3.2	4.6	16.1	-1.1	-1.3	1.1	-4.0	-1.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.3	0.6	0.5	0.4	-0.6	0.1
Cholesterol lowering medication	0.8	1.2	1.7	1.3	1.3	-1.3	-0.6	0.9
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.6	0.2	-0.1	0.6	0.1
Pain experienced in last month	0.5	0.8	2.0	-0.3	-0.4	-1.3	-1.4	0.2
Supplements: Calcium	0.2	0.2	0.3	-0.2	-0.2	0.5	-0.5	-0.5
Basal cell carcinoma (self-reported)	3.1	3.7	9.7	0.5	0.5	-2.7	-3.1	1.0
Heart attack/myocardial infarction (self-reported)	0.9	1.2	2.5	1.1	1.1	-0.8	0.6	1.6
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	1.1	-1.1	-0.6	1.1	-1.0	-1.0
Heart disease (siblings)	1.1	1.4	2.0	-1.3	-1.4	0.6	1.0	-1.3
Alcohol drinker status: Previous	0.3	0.4	1.2	-0.3	-0.3	1.1	0.7	-0.3
Pack years of smoking	2.1	3.1	6.1	2.0	1.6	-1.2	1.0	2.5
Impedance of whole body	0.4	2.2	5.9	-0.0	0.4	-2.2	-2.4	-0.0
Leg fat mass (left)	0.6	2.3	6.2	0.2	-0.4	2.3	2.5	0.1
Arm predicted mass (left)	0.8	4.0	7.4	-1.4	-1.9	2.7	2.6	-0.5