TWAS hub - RABEP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1078	0.0528	2.0e-03	-0.003	NA	0.032	NA	-0.004	7.3e-01	NA	0.00140	NA	9.6e-01
2	ROSMAP	Brain Pre-frontal Cortex	0.0505	0.0251	5.6e-05	0.034	0.032	0.029	0.031	0.031	3.1e-05	4.8e-05	0.00011	5.7e-05	6.7e-05
3	TCGA	Liver Hepatocellular Carcinoma	0.1650	0.1010	1.0e-03	0.049	0.069	0.036	NA	0.043	2.5e-03	3.6e-04	0.00860	NA	4.4e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Trunk fat mass	13.7	59.0	121.0	7.4	11.0	1.4
Trunk fat percentage	13.5	54.3	114.5	6.9	10.7	1.0
Waist circumference	13.3	48.6	98.0	6.9	9.9	0.8
Hip circumference	13.0	56.2	112.4	7.5	10.6	0.8
Arm fat percentage (left)	13.0	51.7	106.1	6.9	10.3	1.0
Whole body fat mass	12.9	53.9	106.1	7.4	10.3	1.1
Arm fat percentage (right)	12.7	50.2	104.0	6.7	10.2	1.4
Arm fat mass (right)	12.6	51.7	100.0	7.3	10.0	1.1
Arm fat mass (left)	12.5	51.3	102.0	7.1	10.1	1.1
Body fat percentage	12.0	47.4	96.8	6.7	9.8	0.9
Leg fat mass (left)	10.5	41.0	76.7	6.8	8.8	0.8
Weight	10.3	50.5	100.0	7.0	10.0	1.4
Leg fat mass (right)	9.9	38.5	70.6	6.7	8.4	0.7
Alcohol intake frequency.	9.7	22.6	48.6	4.3	7.0	1.0
Intelligence (Savage-Jansen 2018)	9.4	29.0	52.0	-5.7	-7.2	1.4
BMI	8.9	51.5	108.2	6.8	10.4	0.8
Body mass index (BMI)	8.6	36.7	69.3	6.4	8.3	0.5
Body Mass Index (BMI) (2010)	7.6	10.5	22.8	2.8	4.8	-0.8
Leg fat percentage (left)	7.5	27.2	52.1	5.4	7.2	0.2
Leg predicted mass (left)	7.2	38.0	70.1	6.5	8.4	1.0
Leg fat-free mass (left)	7.0	37.3	68.1	6.5	8.2	1.1
Leg fat-free mass (right)	6.8	36.4	69.1	6.2	8.3	1.3
Leg predicted mass (right)	6.8	36.2	68.2	6.2	8.3	1.3
Suffer from ‘nerves’	6.7	10.5	16.5	4.1	3.8	-0.5
Leg fat percentage (right)	6.6	24.0	43.5	5.3	6.6	0.3
Comparative body size at age 10	6.0	16.6	42.6	2.6	6.5	0.5
Verbal and Numeric Reasoning (VNR)	5.9	14.2	23.9	-4.3	-4.9	0.8
Crohns Disease (2017)	5.7	12.4	28.0	3.0	5.3	-0.2
Irritable Bowel Disease (IBD)	5.6	13.3	28.9	3.2	5.4	-0.8
Basal metabolic rate	5.3	29.4	52.9	5.8	7.3	1.3
Number of live births	4.8	6.8	12.8	-0.6	-2.7	-3.6
Crohns Disease (2012)	4.5	7.2	21.1	0.0	4.6	0.8
Blood Platelet Count	4.5	52.3	112.4	6.6	1.1	-10.6
Fluid intelligence score	4.2	8.6	14.6	-3.2	-3.8	1.0
Medication: Paracetamol	4.1	6.4	12.6	3.5	2.5	-0.4
Pulse wave peak to peak time	3.9	4.5	12.9	-0.8	3.6	0.3
Qualifications: College or University degree	3.8	11.9	34.2	-0.8	-5.8	-0.9
Whole body fat-free mass	3.7	21.2	36.4	5.1	6.0	1.1
Handedness (chirality/laterality): Left-handed	3.5	4.2	9.0	1.8	3.0	0.6
Whole body water mass	3.5	20.2	34.2	5.0	5.8	1.1
Allergy or Eczema	3.3	8.6	10.9	-2.4	-3.0	-3.3
Pack years adult smoking proportion	3.3	5.1	7.9	2.8	2.3	-1.4
Number of children fathered	3.3	3.8	8.9	0.1	-3.0	-1.5
Arm fat-free mass (left)	3.3	16.8	25.7	4.9	5.1	0.7
Arm predicted mass (right)	3.1	15.7	23.3	4.8	4.8	0.8
Arm predicted mass (left)	3.1	16.0	25.0	4.7	5.0	0.7
Pulse wave Arterial Stiffness index	3.0	3.5	9.5	0.9	-3.1	-0.2
Breastfed as a baby	3.0	3.7	9.8	-1.1	-3.1	0.3
Arm fat-free mass (right)	3.0	15.3	22.7	4.7	4.8	0.9
Commuting to job workplace: Walk	3.0	3.3	5.4	1.8	-1.0	-2.3
Hypothyroidism (self reported)	2.9	6.7	12.7	3.6	2.7	-0.2
Ever had hysterectomy (womb removed)	2.9	3.2	5.0	1.4	-1.7	-2.2
Ulcerative Colitis (UC)	2.8	5.2	8.4	1.9	2.9	-1.9
Happiness	2.8	3.4	6.7	-1.8	-2.6	0.6
Medication: Paracetamol	2.8	4.7	8.3	2.9	2.2	-0.9
Comparative height size at age 10	2.7	14.8	30.8	3.2	5.5	1.9
Ever taken oral contraceptive pill	2.7	3.0	4.5	-1.6	-1.4	-2.1
Alcohol drinker status: Never	2.7	3.2	4.6	2.1	2.1	0.8
Blood Red Count	2.6	25.3	62.9	-3.0	-7.9	1.9
Alcohol usually taken with meals	2.6	4.2	6.4	-2.5	-2.5	-0.0
Lung cancer (father)	2.5	2.9	4.4	1.0	2.1	1.8
Ever smoked	2.5	4.5	10.9	-1.5	-3.3	-0.4
Smoking status: Previous	2.4	3.6	6.4	-1.2	-2.5	1.7
Eye problems/disorders: Glaucoma	2.4	2.9	4.0	1.1	-1.8	-2.0
Qualifications: None of the above	2.3	5.0	12.0	1.7	3.5	0.3
Blood clot in the leg (DVT)	2.3	3.0	6.1	2.5	-1.3	-1.1
Mouth/teeth dental problems: Loose teeth	2.3	2.8	4.1	1.4	2.0	-1.5
Heart disease (mother)	2.3	2.8	5.4	1.2	-1.2	-2.3
Mineral and other dietary supplements	2.3	3.0	6.9	2.6	-0.7	-1.3
Rheumatoid Arthritis	2.2	3.1	9.1	0.0	3.0	-0.3
Lung FVC	2.2	11.1	15.3	-3.9	-2.7	3.3
Medication: Co-codamol	2.2	2.6	4.3	1.7	2.1	-0.8
Hayfever/allergic rhinitis (self-reported)	2.2	3.0	5.6	0.6	-1.7	-2.4
Birth weight of first child	2.2	4.0	6.1	2.3	2.5	0.5
Alzheimer’s Disease (in mother)	2.1	2.5	5.1	-1.6	0.1	2.3
Long-standing illness, disability or infirmity	2.1	3.2	5.5	1.1	2.3	-1.7
Osteoporosis (self-reported)	2.1	2.6	4.8	-2.2	-1.0	1.4
Pack years of smoking	2.1	3.1	4.6	2.1	1.8	-1.2
HbA1C	2.0	2.2	5.3	2.3	0.9	-0.6
Impedance of leg (right)	2.0	9.9	20.5	-3.0	-4.5	-0.7
Eye problems/disorders: None of the above	2.0	2.3	3.6	1.6	1.9	0.9
Mean Putamen Volume	1.9	2.2	6.4	-0.2	-2.5	-0.4
Hand grip strength (right)	1.9	5.3	14.9	-0.3	-3.9	0.9
Fed-up feelings	1.9	3.5	5.8	1.9	2.4	-1.0
Qualifications: CSEs or equivalent	1.9	2.6	6.0	1.2	2.5	-0.4
Trunk fat-free mass	1.9	10.9	16.4	3.9	4.0	1.1
Trunk predicted mass	1.9	10.7	15.8	3.9	4.0	1.0
Worry too long after embarrassment	1.9	3.2	6.2	0.8	-2.5	-1.6
Nervous feelings	1.8	3.4	4.3	2.1	1.6	-1.8
Prospective memory result	1.8	2.2	4.5	0.1	2.1	1.4
Pulse wave reflection index	1.8	2.3	6.0	0.9	-2.4	0.0
Pulse rate, automated reading	1.8	5.8	13.3	1.7	1.0	-3.6
Family relationship satisfaction	1.8	2.2	2.7	-1.0	-1.6	1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	4.6	-0.3	-2.1	1.3
Illnesses of siblings: Diabetes	1.8	2.2	6.3	0.5	2.5	0.4
Primary Biliary Cirrhosis	1.7	2.4	5.3	-2.3	1.1	0.9
Impedance of leg (left)	1.7	8.5	16.3	-3.0	-4.0	-0.5
Mean time to correctly identify matches	1.7	3.2	7.2	-0.3	-1.6	-2.7
HDL Cholesterol	1.6	2.7	4.8	-1.2	-1.3	2.2
Respiratory disease	1.6	3.6	6.6	0.6	-1.9	-2.6
Hayfever, allergic rhinitis or eczema	1.6	3.5	7.1	-0.1	-1.9	-2.7
Father’s age at death	1.6	2.2	3.5	1.9	-1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.4	6.2	1.8	2.5	0.7
Loneliness, isolation	1.6	2.2	5.0	2.2	1.1	0.6
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.3	-2.3	0.2	1.0
Risk taking	1.6	2.3	4.5	-1.0	-2.1	1.3
Multivitamins +/- minerals	1.5	1.9	3.6	-1.9	-1.3	0.6
High blood pressure (mother)	1.5	2.0	5.3	0.8	0.5	-2.3
Past tobacco smoking	1.5	2.8	6.6	0.8	2.6	-1.0
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	5.0	-0.3	-2.2	-0.4
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	4.8	2.2	1.9	-0.1
Medication: Amlodipine	1.5	2.1	5.1	0.1	2.2	1.1
Medication: Ibuprofen	1.5	1.8	4.7	0.6	0.7	-2.2
Chest pain or discomfort	1.5	2.2	5.6	2.4	0.9	-0.2
Commuting to job workplace: Car/motor vehicle	1.5	1.7	3.5	-0.1	1.9	1.3
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	2.6	-1.6	-1.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	7.0	-1.1	-2.7	1.2
Deep venous thrombosis (DVT) (self-reported)	1.5	2.0	4.3	2.1	-1.1	-0.7
Alzheimer’s Disease (including proxy)	1.4	2.0	3.7	-0.6	-1.4	1.9
Reaction Time	1.4	2.7	7.8	0.1	-0.6	-2.8
Ulcerative Colitis	1.4	2.0	6.0	0.0	2.5	-0.2
Blood White Count	1.4	10.3	17.4	4.2	0.1	-3.7
Pain all over the body in last month	1.4	1.5	3.5	-0.6	0.8	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.7	4.7	-0.2	0.7	-2.2
Exposure to tobacco smoke outside home	1.4	1.8	5.0	-0.0	0.7	2.2
Age at first live birth	1.4	2.4	3.5	-1.0	1.9	1.7
Hypertension (Self-reported)	1.4	4.0	10.4	0.1	3.2	1.2
Average weekly red wine intake	1.4	2.1	3.1	-1.8	-1.3	1.2
Friendships satisfaction	1.4	1.7	4.1	-1.0	-2.0	0.2
Illnesses of father: High blood pressure	1.4	1.7	3.4	1.0	-0.8	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.9	0.8	-1.2	1.7
Alzheimer’s Disease (in father)	1.3	1.4	2.2	1.5	-1.4	0.0
Cardiovascular Disease	1.3	4.4	10.9	1.4	3.3	0.6
High blood pressure	1.3	3.7	9.4	0.3	3.1	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.3	2.1	1.4	0.1
Exposure to tobacco smoke at home	1.3	1.5	4.0	0.6	-0.2	-2.0
Peak expiratory flow (PEF)	1.3	3.1	5.6	-0.6	1.8	2.4
Loud music exposure frequency	1.3	1.4	2.2	0.1	1.4	1.5
Hearing aid user	1.3	1.5	2.5	1.6	0.1	-1.4
Mother’s age at death	1.3	1.6	2.9	-1.7	-0.2	1.4
Diastolic blood pressure, automated reading	1.3	4.1	6.8	2.6	2.4	0.3
Unable to work because of sickness or disability	1.3	1.7	2.9	0.6	1.3	1.7
Alcohol drinker status: Previous	1.3	1.5	2.7	1.7	1.3	-0.1
Lupus	1.2	1.8	3.2	1.8	0.5	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	4.2	0.1	2.0	0.7
Supplements: Glucosamine	1.2	1.6	2.4	-1.5	1.5	-0.0
Medication: Levothyroxine sodium	1.2	2.0	4.3	2.1	1.3	-0.3
Overall health rating	1.2	2.6	4.4	1.6	2.1	-0.8
Myopia	1.2	1.7	3.6	-1.0	-1.9	-0.6
Chronotype (morning person)	1.1	2.7	6.9	0.5	2.6	-0.9
Allergy	1.1	2.6	5.2	-0.5	1.5	2.3
Pulse rate	1.1	1.9	4.1	-0.6	-1.2	-2.0
Standing height	1.1	11.0	22.2	2.4	4.7	2.2
Headache pain in last month	1.1	1.8	4.1	1.1	2.0	-0.2
Medication: Blood pressure	1.1	1.9	5.2	0.7	2.3	-0.2
Eye problems/disorders: Cataract	1.1	1.3	1.9	-1.4	-1.4	-0.1
Medication: Gliclazide	1.1	1.3	3.2	-0.3	1.8	-0.8
Illnesses of father: None of the above (group 1)	1.1	1.3	2.6	-0.7	0.9	1.6
Average weekly champagne plus white wine intake	1.1	1.6	3.1	-0.9	-1.8	-0.9
Miserableness	1.1	1.8	4.1	1.1	2.0	0.3
Commuting to job workplace: Public transport	1.1	1.3	3.2	-0.9	-1.8	-0.2
Vascular/heart problems diagnosed by doctor	1.1	3.0	7.0	-0.1	-2.6	-1.4
Bipolar Disorder (2018)	1.0	1.6	4.9	0.0	2.2	-0.1
Bipolar Disorder or Schizophrenia	1.0	2.3	6.7	-0.1	2.6	0.6
Current tobacco smoking	1.0	1.7	2.7	1.7	0.9	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.2	0.8	-1.3	-1.5
Forced vital capacity (FVC)	1.0	3.8	9.6	-1.0	1.0	3.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.4	9.0	-1.1	0.1	3.0
Qualifications: A levels/AS levels or equivalent	1.0	2.3	4.7	-1.4	-2.2	0.2
Gout (self-reported)	1.0	1.4	2.1	-0.8	1.3	1.4
Birth weight	1.0	2.2	3.3	1.8	1.8	-0.1
Medication: Omeprazole	1.0	1.2	1.8	0.7	-1.2	1.3
Diabetes diagnosed by doctor	1.0	1.6	2.3	-0.6	1.5	-1.5
Average weekly beer plus cider intake	1.0	1.4	3.7	1.9	0.7	-0.2
Irritability	1.0	1.8	3.4	-1.8	-1.2	0.7
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.9	-0.5	2.0	-0.9
Relative age of first facial hair	0.9	1.8	4.7	0.6	-2.2	-0.5
Systolic blood pressure, automated reading	0.9	2.7	4.3	1.7	2.1	0.9
Medication for hormone replacement therapy	0.9	1.0	2.3	-0.5	-0.7	-1.5
Medication: Metformin	0.9	1.3	3.7	-0.2	1.9	-0.2
Hair/balding pattern: Pattern 4	0.9	2.2	3.9	-2.0	-1.0	-1.3
Glaucoma (self-reported)	0.9	1.0	1.6	0.1	-1.2	-1.2
Migraine (self-reported)	0.9	1.1	2.8	-1.7	-0.7	0.1
Number of full sisters	0.9	1.1	2.7	-1.6	-0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	1.8	1.0	1.4	0.7
Smoking status: Current	0.9	1.4	2.5	1.6	1.0	-0.9
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.8	0.9	0.0	-1.7
Medication: Atorvastatin	0.9	1.1	2.5	-1.6	-0.7	-0.5
Ever depressed for a whole week	0.9	1.1	2.0	0.8	-1.4	0.8
Cholesterol lowering medication	0.9	1.4	2.4	0.3	-1.5	-1.3
Fasting Glucose	0.8	0.9	1.6	1.3	0.9	-0.6
Neuroticism (2016)	0.8	1.1	2.2	1.0	0.3	-1.5
Triglycerides	0.8	1.3	3.3	1.8	-0.2	-0.9
Hand grip strength (left)	0.8	2.0	3.1	-0.5	-1.6	1.7
Average weekly spirits intake	0.8	1.0	1.5	1.2	-1.2	-0.0
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.0	1.7	-0.2	-0.7
Diabetes (father)	0.8	1.0	1.6	-1.0	0.7	-1.3
Number of incorrect matches in round	0.8	1.3	3.1	-1.8	-0.5	0.8
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	1.5	1.2	-1.1	-0.5
Mouth/teeth dental problems	0.8	1.2	2.9	-0.0	-1.7	-0.8
Diabetes (self-reported)	0.8	1.3	3.3	-0.3	1.8	-0.7
Mouth/teeth dental problems: Dentures	0.8	1.3	2.6	-0.6	0.9	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	6.0	-1.2	-0.2	2.4
Number of full brothers	0.8	1.0	1.2	1.0	-1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.7	0.1	-1.6	-0.5
Emphysema/chronic bronchitis	0.8	0.9	1.5	-0.3	1.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.9	-0.7	0.6	1.4
Knee pain experienced in last month	0.8	1.2	2.1	1.1	0.6	-1.5
Medication for cholesterol	0.8	1.3	2.0	1.3	0.2	1.4
Blood Eosinophil Count	0.7	5.4	9.8	3.1	2.3	-1.1
Number of treatments/medications taken	0.7	1.2	2.8	0.3	1.7	-0.8
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.6	0.3	-1.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.7	0.1	0.8	-1.3
Heart attack	0.7	0.8	1.5	0.7	1.2	0.8
Illnesses of siblings	0.7	1.0	2.9	-0.3	-1.7	0.2
Asthma	0.7	1.4	2.4	0.9	-0.9	-1.5
Medication: Cholesterol lowering	0.7	1.0	2.4	-1.6	0.8	-0.1
High blood pressure (siblings)	0.7	1.0	2.2	0.2	0.8	-1.5
Wheeze or whistling in the chest in last year	0.7	1.3	1.6	1.0	1.3	-1.2
Health satisfaction	0.7	0.8	2.1	-0.1	-1.4	0.7
Shortness of breath walking on level ground	0.7	0.8	1.5	0.9	1.2	-0.5
Neck or shoulder pain in last month	0.7	1.0	2.9	-0.3	-1.7	0.0
Number of self-reported non-cancer illnesses	0.7	1.2	3.0	0.5	1.7	-0.7
Wears glasses or contact lenses	0.7	0.8	1.9	0.2	0.7	-1.4
Number of operations (self-reported)	0.7	1.1	2.2	0.5	-0.9	-1.5
Schizophrenia (2018)	0.6	1.3	2.8	-0.6	1.7	0.8
LDL Cholesterol	0.6	0.9	1.7	0.3	-0.9	-1.3
Schizophrenia (2014)	0.6	1.3	3.5	-0.2	1.9	-0.5
Height	0.6	11.5	17.6	2.3	4.2	3.4
Angina	0.6	0.8	1.1	0.8	-1.0	-0.8
Maternal smoking around birth	0.6	0.8	1.6	0.4	-1.3	-0.8
Had menopause	0.6	0.8	1.8	1.3	0.6	-0.5
Medication: Ramipril	0.6	0.8	2.0	0.5	1.4	0.2
Illnesses of mother	0.6	0.7	1.1	-0.9	0.6	1.1
Length of working week for main job	0.6	0.7	1.3	1.1	0.8	-0.3
Tense / ‘highly strung’	0.6	1.0	2.2	-0.6	-0.5	1.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.7	0.7	1.3	-0.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.8	1.3	-0.5	-0.1
Forced vital capacity (FVC), Best measure	0.6	2.1	5.6	-0.5	0.6	2.4
Medication: Aspirin	0.6	0.7	1.2	-0.8	-1.1	-0.5
Mood swings	0.6	1.2	1.7	0.5	1.2	-1.3
Ever had bowel cancer screening	0.6	0.6	1.1	-1.0	-0.7	-0.6
Asthma (self-reported)	0.6	1.2	2.0	1.1	-0.7	-1.4
Osteoarthritis (self-reported)	0.6	0.8	1.5	0.3	1.2	-0.9
Tinnitus: Yes, now most or all of the time	0.6	0.6	0.9	0.9	0.8	-0.6
Medication: Bendroflumethiazide	0.6	0.9	2.6	0.2	1.6	0.0
Medication: Lisinopril	0.6	0.8	2.0	0.4	1.4	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	0.9	1.1	0.6
Depressed Affect (Nagel 2018)	0.5	1.1	2.2	0.5	1.5	-0.9
Worry (Nagel 2018)	0.5	1.0	2.1	0.8	1.4	-0.3
Smoking Status	0.5	1.2	1.8	-0.6	-1.3	1.3
Vitamin and mineral supplements	0.5	0.7	1.2	1.1	-0.1	-1.0
Supplements: Zinc	0.5	0.5	1.3	0.0	-0.6	-1.2
Relative age voice broke	0.5	0.7	1.3	0.9	-1.1	-0.1
Taking other prescription medications	0.5	0.8	1.4	1.2	-0.4	-0.9
Sitting height	0.5	3.2	8.5	0.9	0.6	2.9
Had other major operations	0.5	0.6	1.0	0.8	-0.1	-1.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	-1.4	-0.7	-0.2
Medication for pain relief, constipation, heartburn	0.5	0.9	1.5	-0.6	-1.2	0.9
Angina (self-reported)	0.5	0.7	0.8	0.9	-0.8	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	0.6	0.0	-1.2
Supplements: Calcium	0.5	0.6	1.5	-0.5	-1.2	-0.1
Breast Cancer	0.4	0.9	1.8	-0.1	-0.9	1.4
Heel T-Score	0.4	3.2	8.2	0.5	-2.9	-1.1
Neuroticism	0.4	1.0	1.9	1.4	0.3	-1.0
Hearing difficulty/problems: Yes	0.4	0.7	1.3	-1.1	0.8	-0.3
Age when periods started (menarche)	0.4	1.0	1.6	-1.2	-1.3	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.2	0.9	1.5	-0.2
Hearing difficulty/problems with background noise	0.4	0.7	1.2	-1.1	-0.8	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	0.9	0.9	-0.5	-0.6
Impedance of arm (right)	0.4	1.7	5.1	-0.0	2.2	0.3
Alcohol intake versus 10 years previously	0.4	0.6	1.8	-0.0	1.3	0.1
Falls in the last year	0.4	0.5	1.2	-1.1	-0.4	0.4
Impedance of arm (left)	0.4	1.9	5.6	-0.2	2.4	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-0.8	0.0	0.9
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.5	0.4	-1.2	0.6
Had major operations	0.4	0.4	1.1	-1.1	-0.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.3	-0.3	1.2	-0.0
Depression (Nagel 2018)	0.3	0.4	1.1	1.1	0.3	-0.3
Waist Hip Ratio (WHR)	0.3	1.3	1.7	0.7	1.2	1.3
Systolic Blood Pressure	0.3	1.6	4.1	0.2	0.7	2.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	-0.9	-0.1	-0.5
Average weekly fortified wine intake	0.3	0.4	0.9	-0.3	0.9	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.4	-0.6	0.6	-0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	0.5	-0.2	0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	1.0	0.9	-0.7
Neuroticism score	0.3	0.6	0.9	0.9	0.8	-0.5
Time employed in main current job	0.3	0.4	0.6	-0.8	0.6	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	-0.3	-0.5	0.9
Medication: Lansoprazole	0.3	0.4	0.4	0.7	0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	1.1	-0.1	0.6
Medication: Ventolin 100micrograms inhaler	0.3	0.3	0.7	0.8	0.5	-0.4
Age at last live birth	0.3	0.4	1.2	0.3	1.1	-0.1
Leg pain on walking	0.3	0.4	1.0	0.2	-1.0	0.2
Supplements: Vitamin C	0.3	0.3	0.7	-0.2	0.8	0.5
Illnesses of father: Heart disease	0.3	0.4	0.6	0.1	-0.8	0.8
Breast cancer (self-reported)	0.3	0.3	0.7	0.2	-0.9	0.3
Medication: Aspirin	0.3	0.4	0.6	-0.6	-0.8	-0.6
Guilty feelings	0.3	0.5	1.2	1.1	0.1	-0.6
Financial situation satisfaction	0.3	0.3	0.8	-0.3	-0.9	-0.3
Medication: Blood pressure	0.3	0.7	1.1	-0.9	1.1	0.2
Fractured/broken bones in last 5 years	0.3	0.4	0.4	0.7	0.6	0.6
Neuroticism (Nagel 2018)	0.2	0.6	0.9	0.7	0.9	-0.6
Age at First Birth	0.2	0.3	0.6	0.8	0.1	-0.4
Lung FEV1/FVC ratio	0.2	0.8	2.3	-0.5	-1.5	0.1
Tanning	0.2	2.1	3.2	-1.7	0.4	1.8
Sensitivity / hurt feelings	0.2	0.3	0.5	0.7	0.6	0.4
Townsend deprivation index at recruitment	0.2	0.2	0.5	-0.3	0.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	0.3	-0.1	-0.9
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.4	-0.8	-0.1
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.2	-0.6	0.7
Depression (self-reported)	0.2	0.2	0.4	0.0	0.6	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.6	-0.0	0.6
Medication: Allopurinol	0.2	0.3	0.5	-0.7	0.6	-0.2
Medication: Seretide 50 evohaler	0.2	0.3	0.8	-0.9	-0.2	-0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	0.3	-0.7	0.0
High cholesterol (Self-reported)	0.2	0.4	0.7	-0.9	0.5	-0.6
Age started oral contraceptive pill	0.2	0.2	0.4	-0.2	0.5	-0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.3	-0.8	0.4
Impedance of whole body	0.2	1.1	2.6	-1.6	-0.9	-0.1
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	0.0	-0.4	0.0
Major Depression (MDD)	0.1	0.2	0.3	0.2	-0.5	0.5
Ovarian Cancer	0.1	0.1	0.2	-0.4	-0.2	-0.1
Hair Pigment	0.1	3.4	6.5	-0.3	-1.9	-2.5
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.2	0.4	-0.1	0.2
Diabetes (mother)	0.1	0.2	0.4	0.2	0.7	-0.2
Severe depression (siblings)	0.1	0.1	0.2	0.5	-0.3	0.3
Stomach or abdominal pain in last month	0.1	0.2	0.5	0.1	-0.7	0.1
Medication: Atenolol	0.1	0.1	0.3	0.2	0.5	-0.3
Medication: Simvastatin	0.1	0.2	0.3	-0.3	0.5	-0.5
Worrier / anxious feelings	0.1	0.1	0.3	0.1	0.6	-0.3
Noisy workplace	0.1	0.1	0.2	-0.2	-0.5	0.2
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.4	-0.6	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	0.1	0.2	0.6
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.1	-0.3	0.4
Pain experienced in last month	0.1	0.1	0.2	-0.4	-0.2	0.3
Heart disease (siblings)	0.1	0.1	0.1	-0.4	0.0	-0.3
Prostate Cancer	0.0	0.1	0.1	-0.3	-0.3	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0
Back pain experienced in last month	0.0	0.1	0.1	0.2	0.1	0.4

Hub : Genes

RABEP2

Models

Trait associations