TWAS hub - RAI14

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1330	0.0380	6.9e-05	-0.002	0.060	0.032	0.058	0.012	6.7e-01	8.5e-08	8.0e-05	1.5e-07	1.2e-02
2	GTEx	Artery Tibial	0.1377	0.0521	1.0e-02	-0.002	NA	0.002	NA	-0.003	5.2e-01	NA	2.0e-01	NA	6.0e-01
3	GTEx	Cells Transformed fibroblasts	0.2250	0.0560	4.3e-05	0.050	NA	0.051	NA	0.041	1.2e-04	NA	9.9e-05	NA	4.5e-04
4	GTEx	Nerve Tibial	0.1974	0.0532	1.2e-04	0.097	NA	0.076	NA	0.083	2.2e-07	NA	4.9e-06	NA	1.9e-06
5	GTEx	Skin Sun Exposed Lower leg	0.2130	0.0520	7.6e-06	0.169	NA	0.158	NA	0.162	5.9e-14	NA	4.7e-13	NA	2.4e-13
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0597	0.0230	6.2e-04	0.008	0.022	0.022	NA	0.015	4.0e-02	1.3e-03	1.5e-03	NA	7.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Qualifications: O levels/GCSEs or equivalent	2.9	4.5	11.1	-0.5	-0.9	2.9	2.2	-3.3	-1.3
Medication: Allopurinol	2.6	3.4	17.9	0.5	0.4	0.6	0.8	4.2	1.2
Bipolar Disorder (2011)	2.4	2.3	7.3	-1.4	0.8	-1.8	-2.7	0.2	-0.7
Relative age voice broke	2.2	3.4	9.9	-1.7	-0.0	-2.4	-0.9	0.8	-3.1
Average weekly spirits intake	2.1	2.6	3.8	0.8	-2.0	-1.7	-1.1	1.9	1.9
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	10.0	0.5	0.9	-2.0	-3.2	-0.2	1.0
Mouth/teeth dental problems	2.1	3.2	11.5	0.1	-2.1	-1.3	0.5	-1.1	-3.4
Lung FEV1/FVC ratio	2.0	9.9	43.2	-0.2	-1.8	-1.2	1.2	6.6	3.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	6.7	0.1	0.5	2.6	2.5	0.7	1.0
Long-standing illness, disability or infirmity	2.0	3.1	10.4	0.5	1.5	-2.0	-3.2	-1.3	0.4
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	4.1	2.0	1.7	-1.6	-2.0	-0.5	0.8
Tinnitus: Yes, but not now, but have in the past	1.9	2.0	8.5	0.1	0.3	0.0	0.8	2.9	1.6
Time employed in main current job	1.8	2.1	8.3	2.9	0.3	-0.6	0.0	1.9	0.5
Medication: Cholesterol lowering	1.8	2.8	6.2	-2.3	1.5	-0.3	0.2	-1.8	-2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	4.0	0.2	2.0	-1.4	-1.8	0.4	1.8
Breast cancer (self-reported)	1.8	2.2	6.4	2.5	0.8	-0.8	-2.3	0.1	0.5
Relative age of first facial hair	1.7	3.5	9.5	-1.6	-0.7	-0.7	-0.3	-2.8	-3.1
Eye problems/disorders: None of the above	1.7	2.0	6.1	-0.0	0.9	1.7	1.0	2.5	0.9
Heart disease (mother)	1.7	2.1	7.3	-0.2	-0.7	2.1	2.7	-0.5	0.0
Chest pain or discomfort	1.7	2.4	8.8	0.8	-0.7	-2.1	-3.0	-0.4	0.4
Knee pain experienced in last month	1.7	2.7	12.6	0.8	-1.1	0.4	0.8	0.9	3.6
Eye problems/disorders: Glaucoma	1.7	2.1	3.7	-1.6	-0.2	1.8	1.9	-1.7	0.1
Medication: Paracetamol	1.7	2.7	8.0	-0.6	0.5	1.7	2.8	1.7	1.3
Medication: Simvastatin	1.6	2.3	6.6	-2.1	0.8	0.9	2.6	-0.4	-1.0
Gout (self-reported)	1.6	2.2	9.0	0.3	0.9	0.9	1.3	3.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.4	12.7	1.2	-0.0	2.5	3.6	0.6	0.2
Bipolar Disorder or Schizophrenia	1.5	3.7	13.8	1.2	-0.9	-3.7	-2.3	0.7	-0.6
Lung cancer (father)	1.5	1.8	6.9	0.3	-0.3	-2.6	-1.8	0.4	-0.1
Glaucoma (self-reported)	1.5	1.8	5.4	-1.0	-0.5	1.3	2.3	-1.5	0.2
Leg pain on walking	1.5	1.8	5.7	0.4	-1.9	1.1	0.1	0.6	2.4
Blood White Count	1.4	10.6	34.3	1.1	-2.0	-3.5	-3.5	5.9	-0.2
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	5.2	1.2	0.4	-1.5	-2.3	-0.6	0.3
Medication: Omeprazole	1.4	1.7	3.7	1.9	1.5	-1.5	-1.2	-0.1	0.4
Diabetes (father)	1.3	1.5	7.0	-0.3	1.2	0.4	-0.6	0.5	2.6
Severe depression (siblings)	1.3	1.5	6.1	0.6	1.0	-0.1	-0.9	0.6	2.5
Pain all over the body in last month	1.3	1.4	6.7	-0.3	-2.6	0.4	0.8	0.9	-0.2
Mouth/teeth dental problems: Dentures	1.3	2.2	7.7	-0.4	1.7	1.1	-0.9	0.5	2.8
Medication: Seretide 50 evohaler	1.3	1.5	7.9	-0.2	2.8	0.1	0.1	-0.1	-1.1
Mineral and other dietary supplements	1.3	1.8	7.2	-2.7	0.9	0.0	1.3	-0.4	-0.9
Illnesses of father: None of the above (group 1)	1.3	1.6	5.5	-0.1	1.2	1.0	0.9	-0.9	-2.3
High cholesterol (Self-reported)	1.3	2.3	6.6	-1.7	2.6	0.5	0.8	-1.6	-0.8
Bipolar Disorder (2018)	1.2	1.9	6.4	0.2	-0.1	-2.5	-1.7	0.7	-1.3
Age at First Birth	1.2	1.7	3.3	0.3	1.8	-1.1	-1.8	-1.2	-1.0
Blood Platelet Count	1.2	13.5	49.3	2.4	-1.2	-4.0	-2.2	7.0	2.0
Blood Red Count	1.2	11.8	38.2	-1.1	1.3	-0.1	-5.2	-6.2	-1.7
Medication: Co-codamol	1.2	1.4	3.7	-0.7	1.1	1.9	-0.4	1.4	0.9
Townsend deprivation index at recruitment	1.2	1.7	3.8	1.6	1.9	0.1	-0.4	2.0	-0.6
Taking other prescription medications	1.2	1.8	6.3	0.1	1.2	-1.3	-2.5	-1.1	0.4
Medication: Levothyroxine sodium	1.2	2.1	9.4	1.7	0.0	0.2	-0.3	-0.3	3.1
Father’s age at death	1.2	1.5	6.2	-2.5	0.1	-0.2	-1.7	0.0	0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	11.3	0.4	-2.1	2.5	3.4	0.5	-0.6
Medication: Paracetamol	1.2	2.0	5.1	-0.5	0.6	1.4	2.3	1.9	0.9
Medication: Aspirin	1.2	1.5	2.6	-1.3	-0.8	-1.4	-1.6	-0.4	-1.5
Guilty feelings	1.2	1.8	6.4	-2.5	1.3	0.2	0.2	-0.8	1.3
Ever depressed for a whole week	1.2	1.5	4.5	-1.6	1.4	-0.1	-2.1	0.1	-0.2
Coronary Artery Disease (CAD)	1.1	1.4	6.1	0.4	1.2	-2.5	-0.6	-0.4	0.3
Type 2 Diabetes (T2D) (2018)	1.1	2.1	6.9	-0.4	0.6	-0.8	-2.6	-1.0	-1.9
Serious illness, injury or assault to yourself	1.1	1.3	5.6	2.4	-0.1	-0.4	-1.0	0.8	0.7
Hayfever, allergic rhinitis or eczema	1.1	2.5	9.7	-0.5	0.7	1.4	0.7	-1.4	-3.1
Stomach or abdominal pain in last month	1.1	1.3	3.5	0.4	1.7	-0.7	-1.9	-0.9	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	8.3	-1.2	0.9	2.9	1.9	0.8	-0.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.3	-0.9	0.7	0.2	-1.8	1.2	1.4
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	3.3	0.6	0.1	1.8	1.2	-0.7	-1.7
Forced expiratory volume in 1-second (FEV1)	1.1	3.8	8.7	0.3	-2.6	2.7	3.0	0.2	-0.4
Pulse wave Arterial Stiffness index	1.1	1.3	5.4	-0.0	-0.2	1.4	2.3	0.4	0.6
Hair/balding pattern: Pattern 4	1.1	2.8	9.9	1.1	-0.9	1.9	0.8	-0.5	-3.2
Had major operations	1.1	1.3	2.7	-0.6	-1.6	-1.4	-1.0	-0.8	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.3	-1.0	1.5	-1.5	-1.3	-0.2	0.5
Illnesses of father: Heart disease	1.1	1.5	4.1	0.4	-1.7	-1.0	0.3	0.8	2.0
Medication: Atorvastatin	1.1	1.4	3.7	-0.2	1.5	-0.4	-1.5	0.3	-1.9
Breast Cancer	1.0	2.4	7.0	0.7	-0.6	0.8	2.6	0.7	2.4
Schizophrenia (2014)	1.0	2.1	6.7	1.7	-0.2	-2.6	-1.7	0.2	-0.5
Chronotype (morning person)	1.0	2.4	5.7	-1.5	2.4	0.1	1.5	1.3	-1.6
Nervous feelings	1.0	1.8	5.6	-2.4	2.2	-0.2	-0.1	-0.8	-0.1
Forced vital capacity (FVC)	1.0	3.9	8.5	0.3	-1.7	2.9	2.5	-2.2	-0.7
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.1	2.7	1.0	-0.4	1.7	-1.2	0.6	-1.0
Illnesses of mother	1.0	1.2	3.4	0.2	0.0	-0.7	-1.8	1.8	0.1
Ever highly irritable/argumentative for 2 days	1.0	1.1	3.6	0.5	-0.3	-0.7	-1.5	1.9	0.4
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.3	-0.4	1.0	0.1	-1.5	-1.3	-1.4
Wheeze or whistling in the chest in last year	1.0	1.8	6.5	1.1	1.0	-1.5	-2.5	0.5	0.0
Pulse wave peak to peak time	1.0	1.2	5.0	-0.1	-0.0	-1.5	-2.2	-0.3	-0.4
Emphysema/chronic bronchitis	1.0	1.2	1.7	-1.3	1.3	0.2	0.5	1.3	1.3
Diabetes diagnosed by doctor	1.0	1.6	4.0	-0.1	-0.7	-0.1	-1.7	-1.4	-2.0
Number of self-reported non-cancer illnesses	1.0	1.8	5.0	-1.1	2.2	-0.9	-1.3	-1.1	-0.7
Average weekly champagne plus white wine intake	1.0	1.3	2.8	-0.1	-1.7	-1.5	-1.2	0.3	1.2
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.2	-0.8	0.2	1.5	1.5	-1.4	0.4
Pain experienced in last month	1.0	1.7	4.2	-0.8	-1.0	1.6	2.1	-0.9	-1.0
Supplements: Calcium	1.0	1.1	2.9	1.4	-0.6	-0.8	-1.7	-0.1	-0.7
Schizophrenia (2018)	0.9	1.8	4.6	1.4	-1.3	-2.1	-1.6	0.4	0.2
Crohns Disease (2017)	0.9	2.0	9.6	-0.1	-0.3	0.3	1.2	3.1	0.7
Irritable Bowel Disease (IBD)	0.9	2.0	10.2	0.3	-0.1	0.1	1.2	3.2	0.5
Major Depression (MDD)	0.9	1.1	5.4	-0.1	2.3	-0.5	0.2	-0.7	-0.7
Crohns Disease (2012)	0.9	1.4	6.3	-1.0	-0.6	-0.2	-0.1	2.5	-0.9
Allergy or Eczema	0.9	2.3	11.6	-0.2	0.8	1.1	0.3	-0.3	-3.4
Angina	0.9	1.2	4.2	-0.7	-0.6	-0.6	-0.6	-2.1	-1.0
Supplements: Zinc	0.9	0.9	2.7	1.7	1.0	0.2	0.9	0.9	-0.6
Medication: Atenolol	0.9	1.1	3.1	-1.1	1.2	0.3	0.6	-1.8	-0.6
Financial difficulties in last 2 years	0.9	1.3	3.3	0.7	1.8	-1.1	0.4	1.2	1.0
Qualifications: A levels/AS levels or equivalent	0.9	2.0	4.7	-0.7	-1.1	-0.0	2.1	-2.2	-1.1
Exposure to tobacco smoke at home	0.9	1.0	2.1	0.4	-0.6	1.0	1.4	1.4	0.6
Birth weight of first child	0.9	1.6	5.8	-0.4	1.3	-1.1	-2.4	0.6	-0.3
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.3	-0.0	1.4	1.5	0.7	0.1	1.5
Blood clot in the leg (DVT)	0.9	1.1	3.1	1.8	-0.6	-1.0	-1.4	0.3	0.4
Mouth/teeth dental problems: Loose teeth	0.9	1.0	2.3	1.1	0.4	1.5	-0.9	1.2	-0.3
Angina (self-reported)	0.9	1.2	3.7	-0.6	-0.8	-0.6	-0.6	-1.9	-1.2
Overall health rating	0.9	2.0	5.8	0.9	-0.6	-2.1	-2.4	-0.7	0.4
Financial situation satisfaction	0.9	1.1	2.6	-0.0	0.5	-1.6	-1.4	1.2	-0.5
Medication: Lisinopril	0.9	1.2	3.5	1.9	0.8	0.1	0.0	-1.7	0.1
Prostate Cancer	0.8	1.2	2.8	-0.7	0.0	1.7	1.2	1.4	-0.1
Neuroticism (2016)	0.8	1.2	3.6	-1.1	1.9	-1.2	0.3	-0.9	0.3
Primary Biliary Cirrhosis	0.8	1.1	3.5	-0.9	1.9	0.1	-1.4	0.4	-0.3
Systolic blood pressure, automated reading	0.8	2.3	6.6	-1.0	2.6	1.9	1.2	1.2	-0.1
Pack years adult smoking proportion	0.8	1.2	2.7	-1.6	-0.9	-1.3	-0.8	0.5	-0.8
Maternal smoking around birth	0.8	1.2	3.9	0.7	0.1	1.1	2.0	-1.1	-0.2
Had menopause	0.8	1.0	3.2	1.8	-0.1	0.4	0.0	0.2	1.6
Length of working week for main job	0.8	0.9	2.7	-0.4	-0.7	0.9	1.0	0.5	-1.6
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.2	1.7	0.7	-0.8	-0.4	-0.7	2.3
Forced vital capacity (FVC), Best measure	0.8	2.8	6.0	0.2	-1.5	2.3	2.4	-1.7	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	3.9	-2.0	-0.5	-0.6	0.8	-0.4	-0.6
Medication: Aspirin	0.8	1.1	2.3	-0.5	-0.8	-1.2	-1.3	0.2	-1.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.6	0.7	-1.6	-0.9	-0.6	-0.2	-1.1
Eye problems/disorders: Cataract	0.8	0.9	2.2	0.4	0.3	-0.5	-0.8	-1.5	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.7	0.6	0.2	0.9	1.3	0.1	1.6
Osteoporosis (self-reported)	0.8	1.0	2.6	-0.5	1.6	-0.5	-1.3	-0.5	-0.9
Supplements: Fish oil (including cod liver oil)	0.8	1.0	3.4	1.4	-1.8	0.6	-0.0	0.5	0.3
Irritability	0.8	1.4	6.9	-0.7	-0.4	-0.4	0.9	-0.1	2.6
Myopia	0.8	1.2	2.2	-0.7	-1.5	-1.3	0.0	1.3	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.8	1.1	3.3	1.8	-0.3	-0.9	-1.4	0.2	0.4
LDL Cholesterol	0.7	1.1	2.4	1.1	1.3	1.1	0.5	-1.6	-0.4
Heel T-Score	0.7	5.6	15.5	-1.7	0.7	3.9	3.8	-0.7	0.1
Cardiovascular Disease	0.7	2.2	8.3	-0.4	2.9	-0.7	0.5	-0.1	-2.0
Lung FVC	0.7	3.5	7.8	-0.1	-1.1	2.4	2.8	-2.3	-1.0
Hearing difficulty/problems: Yes	0.7	1.0	3.0	-1.0	-0.5	0.1	-1.3	0.6	1.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.5	-0.9	1.0	-0.9	-1.2	0.4	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	5.6	0.1	0.5	2.4	1.6	0.8	-0.6
Qualifications: CSEs or equivalent	0.7	1.0	3.1	-1.8	0.6	1.0	-0.0	0.4	-1.1
Number of incorrect matches in round	0.7	1.2	4.0	0.6	2.0	-0.0	-0.2	-1.4	0.9
Hearing difficulty/problems with background noise	0.7	1.1	2.3	0.7	1.3	-0.5	-1.4	-0.1	1.5
Depression (self-reported)	0.7	0.8	1.7	-1.1	0.6	-0.5	-0.9	-1.3	0.5
Tense / ‘highly strung’	0.7	1.1	3.0	0.2	1.2	-0.5	-1.4	-0.1	1.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.3	0.3	-1.5	0.6	-0.1	1.1	1.8
Medication: Ventolin 100micrograms inhaler	0.7	1.0	4.2	0.5	2.0	-0.4	-0.6	-0.9	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	3.7	-0.2	1.9	-0.5	-0.3	-0.9	0.7
Health satisfaction	0.7	0.9	2.3	-0.6	0.1	-1.5	-1.0	-1.1	0.6
Mood swings	0.7	1.3	3.5	-1.9	-0.1	-0.1	1.0	0.3	1.8
Ever had bowel cancer screening	0.7	0.8	3.8	-0.6	-0.5	0.1	-0.2	-1.9	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.1	0.7	0.1	1.4	0.3	-0.0	-1.5
Friendships satisfaction	0.7	0.9	4.6	-0.5	0.0	-2.1	-0.4	-0.4	-0.3
Commuting to job workplace: Walk	0.7	0.7	2.0	0.6	1.1	1.4	0.6	0.4	0.4
Pain type(s) experienced in last month: Hip pain	0.7	0.9	4.7	-0.6	0.0	-0.4	-0.3	2.2	0.6
Number of operations (self-reported)	0.7	1.1	4.0	-0.6	-0.3	-2.0	-1.2	-0.3	0.5
Risk taking	0.7	1.1	2.3	-0.9	-1.3	1.1	1.5	0.6	-0.3
Commuting to job workplace: Cycle	0.7	0.9	2.0	-0.1	-0.3	1.4	-1.1	-1.2	0.7
Ulcerative Colitis (UC)	0.6	1.1	5.2	0.4	0.1	-0.4	0.9	2.3	0.4
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.2	0.0	0.5	-0.7	-1.5	-0.1	-1.0
Systolic Blood Pressure	0.6	3.1	5.3	-0.7	2.3	2.0	1.5	2.1	-1.3
Age when periods started (menarche)	0.6	1.6	3.9	0.0	-1.1	0.4	-2.0	-1.7	-1.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	-0.5	0.3	-1.3	-1.2	0.5	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.9	0.7	1.2	-1.0	-0.8	0.4	1.4
Diabetes (self-reported)	0.6	1.0	3.0	-0.4	-0.3	0.5	-0.9	-1.2	-1.7
Illnesses of siblings	0.6	0.9	3.4	0.1	0.6	-0.8	-0.6	0.7	-1.8
Hair/balding pattern: Pattern 3	0.6	0.9	2.8	-0.8	0.2	-0.2	0.3	-1.7	1.4
Asthma	0.6	1.1	3.8	-0.2	1.5	2.0	0.7	-0.5	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.9	-0.4	-1.0	-0.4	0.9	1.4	0.9
Pulse wave reflection index	0.6	0.7	1.3	1.1	1.1	-0.6	0.8	-1.0	-0.3
Medication: Amlodipine	0.6	0.8	2.5	0.7	0.3	-1.0	0.1	0.9	-1.6
Worry too long after embarrassment	0.6	1.0	1.8	-1.3	-0.0	1.1	0.6	-1.3	0.9
Neck or shoulder pain in last month	0.6	0.9	1.9	0.5	1.1	-1.1	-0.9	0.1	1.4
Alcohol intake frequency.	0.6	1.4	5.3	-1.0	0.1	2.3	1.2	-0.1	-0.8
Age at last live birth	0.6	0.8	2.5	-0.3	-1.2	-0.6	-0.4	0.8	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	1.1	-0.7	-0.5	0.9	-1.0	-0.7
Illnesses of siblings: Diabetes	0.6	0.7	1.7	0.8	-1.1	-0.3	-0.6	-0.2	1.3
Medication for cholesterol	0.6	0.9	2.1	0.8	-1.4	-0.9	-1.1	0.0	0.7
Back pain experienced in last month	0.6	0.9	2.5	0.9	-1.6	-0.1	-1.4	-0.1	0.3
Miserableness	0.6	1.0	2.8	-1.7	0.9	-1.3	0.1	-0.6	0.6
Wears glasses or contact lenses	0.6	0.6	2.2	-0.7	0.1	0.5	0.8	-0.6	1.5
Pack years of smoking	0.6	0.8	2.1	-1.4	-0.9	-0.9	-0.8	0.7	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.8	-0.2	-0.1	-0.8	-1.3	-0.7	-0.1
Lupus	0.5	0.8	2.1	-0.8	0.6	-1.0	0.1	-1.5	-1.0
Waist Hip Ratio (WHR)	0.5	2.4	10.8	-0.2	-1.2	-1.2	-3.3	0.6	0.3
Number of treatments/medications taken	0.5	0.8	1.9	1.0	0.7	-0.9	-1.4	-0.7	0.2
Medication for hormone replacement therapy	0.5	0.5	1.3	-0.0	1.2	0.7	-0.0	-0.7	-1.0
Medication: Metformin	0.5	0.7	3.1	-0.0	-0.4	-0.5	-1.8	-0.8	-0.1
Supplements: Glucosamine	0.5	0.6	1.9	0.7	0.2	0.2	-0.1	1.1	1.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.1	-0.2	0.7	-1.4	-0.9	0.0	0.3
Waist circumference	0.5	1.8	4.5	1.7	-1.0	-1.2	-2.1	0.8	0.5
Past tobacco smoking	0.5	0.9	3.4	-0.7	-0.9	0.6	0.6	0.4	-1.8
Alcohol usually taken with meals	0.5	0.8	1.9	0.9	-1.2	-1.4	-0.2	-0.4	0.3
Allergy	0.5	1.1	3.8	-0.2	-1.1	-0.7	-0.1	1.0	1.9
Alcohol intake versus 10 years previously	0.5	0.8	2.0	0.6	0.7	0.7	1.2	1.4	-0.5
Noisy workplace	0.5	0.6	1.3	-0.6	1.0	0.3	-0.1	1.1	1.0
Medication: Lansoprazole	0.5	0.6	2.4	-0.5	-0.4	-0.3	-1.6	0.5	0.4
Breastfed as a baby	0.5	0.7	2.8	0.7	-0.5	-0.1	-1.7	-0.6	0.1
Family relationship satisfaction	0.5	0.6	1.9	-0.5	-0.3	-0.9	-1.4	0.7	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	3.9	0.8	0.2	-0.5	-0.2	0.4	2.0
Asthma (self-reported)	0.5	1.0	3.2	-0.4	1.3	1.8	0.7	-0.6	0.2
Hearing aid user	0.5	0.6	1.1	-0.4	-1.0	0.3	1.0	0.4	0.9
Medication: Blood pressure	0.5	0.9	2.7	-1.0	1.6	0.4	0.9	-0.4	-0.6
Ever smoked	0.5	0.8	4.0	0.4	-0.1	-0.7	-0.0	-0.2	2.0
Fractured/broken bones in last 5 years	0.5	0.6	1.2	1.0	0.2	-0.8	-1.1	-0.3	-0.9
Age started oral contraceptive pill	0.5	0.7	2.0	-1.4	0.5	-0.5	-1.0	-0.8	0.2
Unable to work because of sickness or disability	0.5	0.6	1.7	-0.3	-1.2	-1.3	-0.2	0.0	-0.4
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.2	0.1	-2.1	0.6	0.2	0.6	1.7
Heart disease (siblings)	0.5	0.7	3.2	0.1	0.7	0.4	1.8	-0.2	0.0
Depression (Nagel 2018)	0.4	0.6	1.4	1.2	0.5	0.1	-0.8	0.0	1.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	2.1	1.0	0.6	-1.4	-1.5	-1.0	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	0.9	-0.4	-0.8	1.0	0.4	-1.0	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.8	-0.5	0.1	-0.2	-0.4	-1.3	1.2
Body Mass Index (BMI) (2010)	0.4	0.5	1.6	-0.6	-0.9	-0.5	-0.2	1.3	0.4
Rheumatoid Arthritis	0.4	0.5	2.2	-0.6	0.6	-0.5	0.1	1.5	0.1
Triglycerides	0.4	0.6	2.1	-1.0	-0.0	1.4	0.4	-0.0	0.7
BMI	0.4	2.4	5.0	1.3	-1.5	-2.2	-1.0	2.1	0.2
Hypothyroidism (self reported)	0.4	1.0	2.5	1.5	0.3	-0.8	-0.1	0.6	1.6
Neuroticism	0.4	0.9	2.9	-1.7	0.1	-0.1	-0.0	-0.8	1.3
Average weekly fortified wine intake	0.4	0.5	1.4	0.5	-0.0	-0.0	0.1	1.1	1.2
Fed-up feelings	0.4	0.7	1.9	-1.4	0.5	-0.6	0.7	-0.7	0.9
High blood pressure	0.4	1.1	4.3	-0.4	2.1	0.1	0.4	-0.2	-1.4
High blood pressure (mother)	0.4	0.6	2.2	-0.4	0.2	0.7	1.5	-0.2	0.8
Fluid intelligence score	0.4	0.8	1.9	-0.1	-0.8	-1.4	-0.1	-1.4	0.5
Neuroticism score	0.4	0.8	2.5	-1.6	0.3	0.1	0.4	-0.9	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	3.4	1.9	0.6	-0.1	0.3	-0.2	-0.6
Falls in the last year	0.4	0.6	1.6	-0.0	0.4	-1.2	-0.4	0.5	1.2
Headache pain in last month	0.4	0.7	1.4	-0.7	0.7	1.2	1.0	0.5	-0.8
Exposure to tobacco smoke outside home	0.4	0.5	1.1	-0.7	0.5	-0.9	0.5	0.5	-1.0
Number of children fathered	0.4	0.5	1.9	-0.9	0.4	0.0	0.2	1.4	0.2
Shortness of breath walking on level ground	0.4	0.5	1.5	-0.6	0.8	0.1	-1.2	-0.6	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.8	0.2	0.7	0.8	0.3	-1.3	-1.1
Medication: Blood pressure	0.4	0.8	2.4	0.7	1.6	-0.3	-0.6	-0.7	-0.9
Medication: Ibuprofen	0.4	0.4	1.1	-0.3	0.1	-0.1	0.7	1.0	0.9
Comparative height size at age 10	0.4	2.3	7.2	2.7	-1.8	1.0	0.8	-0.5	1.3
Suffer from ‘nerves’	0.4	0.6	2.6	-0.2	1.6	0.1	0.8	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	3.2	0.2	-0.1	0.5	-1.0	-0.5	-1.8
Qualifications: nursing, teaching	0.4	0.7	1.8	-0.4	-1.3	-0.5	0.1	-1.4	-0.1
Mother’s age at death	0.4	0.5	1.6	-0.9	-0.1	1.3	-0.1	0.3	0.7
Tinnitus: Yes, now most or all of the time	0.4	0.5	2.2	-0.7	0.2	1.5	0.4	0.1	-0.3
Illnesses of father: High blood pressure	0.4	0.4	2.4	-1.6	-0.4	-0.1	0.2	0.1	-0.1
Alcohol drinker status: Never	0.4	0.5	1.4	-0.5	-1.2	0.5	0.6	-0.8	0.1
Diastolic blood pressure, automated reading	0.4	1.1	2.7	-1.2	0.9	1.0	1.7	0.0	-0.6
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	-0.9	-0.5	-0.4	-0.4	-0.9	-0.9
Depressed Affect (Nagel 2018)	0.3	0.5	2.6	-1.6	0.3	-0.0	0.1	0.1	0.7
Schizophrenia vs Biploar Disorder	0.3	0.5	1.3	0.2	0.6	0.1	1.1	-1.0	0.1
Reaction Time	0.3	0.6	2.2	-1.5	0.4	-0.4	0.4	-0.9	0.0
Mean Putamen Volume	0.3	0.4	1.4	1.2	0.3	0.2	0.4	0.3	0.8
Ulcerative Colitis	0.3	0.5	1.4	-0.8	-0.4	0.4	0.7	1.2	0.3
Respiratory disease	0.3	0.8	1.8	-1.0	1.3	1.1	0.7	-0.3	-0.1
Tanning	0.3	3.1	6.2	2.1	1.5	-1.4	-1.0	2.5	1.7
Hand grip strength (left)	0.3	0.8	1.5	1.2	0.8	-0.1	0.2	-1.2	-1.1
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.6	-0.2	-0.2	-0.8	-1.3	-0.4	0.2
Vitamin and mineral supplements	0.3	0.4	1.1	-1.1	-0.6	0.2	0.2	0.2	-0.8
Diabetes (mother)	0.3	0.3	1.4	-0.1	0.3	0.4	1.2	-0.6	0.2
Current tobacco smoking	0.3	0.5	2.3	0.4	0.1	-0.5	-0.3	1.5	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.6	-0.4	-0.3	-0.3	-0.8	1.0
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.1	-0.6	0.3	0.2	0.6	0.1	1.1
Body mass index (BMI)	0.3	1.2	2.5	1.6	-0.7	-1.3	-0.5	1.4	0.4
Had other major operations	0.3	0.3	0.7	-0.7	-0.4	0.1	0.0	-0.9	-0.8
Qualifications: None of the above	0.3	0.5	1.5	-0.8	1.2	0.5	-0.8	0.4	0.2
Heart attack	0.3	0.4	0.8	-0.8	-0.2	-0.4	-0.3	-0.9	-0.7
Weight	0.3	1.4	4.3	2.1	-1.4	-0.5	-0.1	1.1	0.8
Prospective memory result	0.3	0.4	1.1	-1.1	-0.5	-0.3	0.4	-0.7	0.7
Impedance of arm (left)	0.3	1.3	3.5	-1.9	-0.4	1.9	0.4	-0.0	-0.6
Peak expiratory flow (PEF)	0.3	0.7	2.2	-0.4	-1.5	1.0	0.4	-0.3	-0.9
Loud music exposure frequency	0.3	0.3	1.0	1.0	-0.0	-0.7	0.2	0.3	-0.7
High blood pressure (siblings)	0.3	0.4	1.9	-0.4	0.3	0.0	0.2	0.4	1.4
Leg fat percentage (right)	0.3	1.2	4.2	1.2	-0.3	-0.6	-0.8	2.1	0.5
Age at first live birth	0.3	0.6	2.0	-1.0	-0.6	-0.1	0.5	0.0	-1.4
Mean time to correctly identify matches	0.3	0.6	1.4	-1.2	1.0	0.1	0.4	-0.8	0.6
Leg fat mass (right)	0.3	1.3	3.3	1.7	-0.9	-0.7	-0.3	1.8	0.5
Supplements: Vitamin C	0.3	0.3	0.7	0.8	-0.4	0.6	0.5	-0.3	0.7
Hypertension (Self-reported)	0.3	1.0	4.0	-0.5	2.0	-0.0	0.5	-0.1	-1.1
Smoking status: Previous	0.3	0.4	1.0	0.3	1.0	-0.2	-0.5	-0.4	1.0
Medication: Gliclazide	0.3	0.3	1.1	-0.6	0.3	0.1	0.4	0.4	1.0
Smoking status: Current	0.3	0.5	1.8	0.9	0.1	-0.4	-0.2	1.4	-0.1
Arm fat mass (left)	0.3	1.1	2.3	1.5	-1.4	-0.5	-0.0	1.3	0.6
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.3	-0.8	0.2	-0.5	0.7	-0.6
Commuting to job workplace: Public transport	0.3	0.3	0.9	-0.8	-0.2	-0.2	-0.2	-0.5	1.0
Cholesterol lowering medication	0.3	0.5	1.1	-0.4	0.8	1.0	0.8	0.3	-0.6
Basal cell carcinoma (self-reported)	0.3	0.4	0.6	-0.4	-0.2	-0.8	-0.8	-0.5	0.7
Alcohol drinker status: Previous	0.3	0.4	1.0	-0.5	1.0	0.9	0.4	-0.1	0.4
Leg fat mass (left)	0.3	1.2	2.7	1.6	-1.1	-0.7	-0.4	1.5	0.5
Neuroticism (Nagel 2018)	0.2	0.6	1.5	-1.1	0.8	0.1	0.0	0.0	1.2
Ovarian Cancer	0.2	0.3	0.6	0.6	-0.2	0.2	-0.1	-0.8	-0.7
Fasting Glucose	0.2	0.3	0.7	-0.8	-0.6	0.7	0.1	0.2	-0.4
HbA1C	0.2	0.3	1.1	0.6	0.1	-0.1	1.0	0.1	0.2
HDL Cholesterol	0.2	0.4	0.9	0.3	1.0	-0.9	0.4	0.3	-0.5
Height	0.2	3.0	6.7	2.2	-0.8	2.6	0.5	0.5	2.3
Smoking Status	0.2	0.6	2.3	0.4	0.5	-1.5	-0.9	0.2	-0.2
Hair Pigment	0.2	6.0	19.9	0.2	0.8	1.4	1.0	-3.5	-4.5
Sensitivity / hurt feelings	0.2	0.4	1.2	0.9	0.3	-1.1	0.0	-0.2	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.7	0.6	0.0	-0.1	-0.5	-0.1	0.9
Impedance of leg (right)	0.2	0.7	2.3	-1.5	-0.1	0.7	-1.1	0.1	-0.7
Leg fat-free mass (left)	0.2	1.2	3.6	1.9	-1.5	-0.4	0.6	0.6	0.6
Trunk fat percentage	0.2	0.8	1.7	1.3	-1.1	0.5	-0.2	1.3	0.3
Hand grip strength (right)	0.2	0.4	1.8	-0.0	-0.0	-0.4	0.1	-1.4	-0.7
Multivitamins +/- minerals	0.2	0.2	0.5	0.2	0.6	-0.7	-0.0	-0.2	0.4
Sitting height	0.2	1.1	2.5	1.1	-1.6	0.7	0.5	-0.7	1.2
Impedance of leg (left)	0.2	1.0	3.0	-1.7	0.0	0.9	-1.3	-0.3	-0.8
Leg predicted mass (left)	0.2	1.2	3.4	1.9	-1.5	-0.4	0.7	0.7	0.5
Trunk fat mass	0.2	1.0	2.7	1.6	-1.3	0.3	-0.0	1.2	0.5
Hair/balding pattern: Pattern 2	0.2	0.2	0.8	-0.3	-0.9	-0.1	-0.2	0.6	0.1
Impedance of arm (right)	0.2	1.2	3.7	-1.2	0.2	1.9	-0.0	0.7	-1.1
Arm fat percentage (right)	0.2	0.7	2.4	1.2	-0.6	0.1	-0.1	1.6	0.3
Trunk fat-free mass	0.2	1.1	3.6	1.9	-1.3	-0.4	0.3	-0.2	1.0
Hip circumference	0.2	0.9	2.5	1.6	-0.8	-0.9	-0.6	1.2	0.0
Number of live births	0.2	0.2	0.4	0.3	-0.6	0.3	-0.6	0.5	-0.3
Pulse rate	0.2	0.4	1.8	1.3	-0.5	-0.0	-0.2	0.4	-0.0
Happiness	0.2	0.2	0.7	-0.9	0.2	-0.3	-0.4	0.1	-0.6
Arm fat mass (right)	0.2	1.0	2.2	1.5	-1.3	-0.6	-0.2	1.2	0.6
Trunk predicted mass	0.2	1.1	3.5	1.9	-1.3	-0.3	0.4	-0.2	1.0
Standing height	0.2	1.6	4.2	1.2	-2.1	1.4	0.6	-0.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.5	-0.4	0.6	0.5	0.5	-0.7	0.1
Birth weight	0.2	0.4	0.7	-0.4	0.6	-0.0	-0.6	-0.8	0.7
Body fat percentage	0.2	0.8	2.1	1.3	-1.0	0.3	-0.3	1.5	0.5
Arm fat-free mass (right)	0.2	1.1	2.8	1.7	-1.7	-0.3	0.4	-0.4	0.9
Qualifications: College or University degree	0.2	0.5	1.3	1.1	-0.5	-1.1	-0.1	-0.4	-0.1
Whole body fat mass	0.2	1.0	2.0	1.4	-1.4	-0.2	-0.1	1.3	0.5
Arm predicted mass (right)	0.2	1.1	3.2	1.8	-1.3	-0.5	0.4	-0.1	1.1
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.0	0.7	0.5	0.1	-0.1	0.2	-1.0
Whole body fat-free mass	0.2	1.2	3.7	1.9	-1.5	-0.3	0.5	0.0	0.9
Leg fat-free mass (right)	0.2	1.0	3.1	1.8	-1.3	-0.3	0.7	0.4	0.5
Arm fat percentage (left)	0.2	0.7	1.8	0.9	-1.1	0.0	0.2	1.3	0.4
Average weekly red wine intake	0.2	0.3	0.9	-0.6	-0.2	-0.3	0.0	-0.9	-0.6
Loneliness, isolation	0.2	0.2	1.1	-0.2	0.1	0.2	-0.3	1.1	0.1
Whole body water mass	0.2	1.1	3.5	1.9	-1.4	-0.3	0.5	0.2	0.9
Leg predicted mass (right)	0.2	1.0	3.3	1.8	-1.5	-0.3	0.6	0.5	0.4
Medication: Bendroflumethiazide	0.2	0.3	0.8	0.3	0.7	0.4	-0.9	-0.0	0.3
Basal metabolic rate	0.2	1.2	3.9	2.0	-1.5	-0.4	0.4	0.3	1.0
Leg fat percentage (left)	0.2	0.8	2.6	1.2	-0.4	-0.4	-0.7	1.6	0.3
Arm fat-free mass (left)	0.2	1.2	3.7	1.9	-1.4	-0.8	-0.3	0.3	1.0
Average weekly beer plus cider intake	0.2	0.3	0.6	-0.3	0.8	0.8	0.1	-0.6	-0.1
Impedance of whole body	0.2	1.2	3.6	-1.9	-0.1	1.7	-0.5	-0.2	-0.8
Arm predicted mass (left)	0.2	1.1	4.3	2.1	-1.1	-0.5	0.1	0.2	1.0
Worry (Nagel 2018)	0.1	0.2	0.4	-0.4	0.3	0.1	-0.5	-0.2	0.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.1	0.5	-0.6	-0.6	-0.7	-0.4
Blood Eosinophil Count	0.1	1.1	2.9	1.7	0.8	-0.3	-1.6	0.5	-0.0
Medication: Ramipril	0.1	0.1	0.3	-0.1	0.0	0.0	-0.3	-0.5	-0.3
Worrier / anxious feelings	0.1	0.2	0.4	-0.1	0.6	-0.2	-0.6	0.5	-0.6
Comparative body size at age 10	0.1	0.4	0.7	0.2	0.7	-0.8	0.8	0.8	-0.0
Number of full brothers	0.1	0.1	0.2	-0.4	0.4	-0.2	-0.1	0.3	-0.5
Pulse rate, automated reading	0.1	0.4	0.9	0.5	-0.4	0.5	-0.0	0.8	-1.0
Number of full sisters	0.1	0.2	0.4	0.2	0.6	-0.3	-0.5	-0.2	-0.4
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.3	0.2	0.5	-0.2	-0.1	0.4
Migraine (self-reported)	0.0	0.1	0.1	0.2	-0.2	0.1	0.4	0.1	0.3

Hub : Genes

RAI14

Models

Trait associations