Hub : Genes

RAI14

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1330 0.0380 6.9e-05 -0.002 0.060 0.032 0.058 0.012 6.7e-01 8.5e-08 8.0e-05 1.5e-07 1.2e-02
2 GTEx Artery Tibial 0.1377 0.0521 1.0e-02 -0.002 NA 0.002 NA -0.003 5.2e-01 NA 2.0e-01 NA 6.0e-01
3 GTEx Cells Transformed fibroblasts 0.2250 0.0560 4.3e-05 0.050 NA 0.051 NA 0.041 1.2e-04 NA 9.9e-05 NA 4.5e-04
4 GTEx Nerve Tibial 0.1974 0.0532 1.2e-04 0.097 NA 0.076 NA 0.083 2.2e-07 NA 4.9e-06 NA 1.9e-06
5 GTEx Skin Sun Exposed Lower leg 0.2130 0.0520 7.6e-06 0.169 NA 0.158 NA 0.162 5.9e-14 NA 4.7e-13 NA 2.4e-13
6 TCGA Kidney Renal Clear Cell Carcinoma 0.0597 0.0230 6.2e-04 0.008 0.022 0.022 NA 0.015 4.0e-02 1.3e-03 1.5e-03 NA 7.3e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.2 1.9 6.4 0.2 -0.1 -2.5 -1.7 0.7 -1.3
Bipolar Disorder or Schizophrenia 1.5 3.7 13.8 1.2 -0.9 -3.7 -2.3 0.7 -0.6
Depressed Affect (Nagel 2018) 0.3 0.5 2.6 -1.6 0.3 -0.0 0.1 0.1 0.7
Depression (Nagel 2018) 0.4 0.6 1.4 1.2 0.5 0.1 -0.8 0.0 1.1
Intelligence (Savage-Jansen 2018) 0.4 1.1 2.1 1.0 0.6 -1.4 -1.5 -1.0 -0.5
Neuroticism (Nagel 2018) 0.2 0.6 1.5 -1.1 0.8 0.1 0.0 0.0 1.2
Schizophrenia (2018) 0.9 1.8 4.6 1.4 -1.3 -2.1 -1.6 0.4 0.2
Schizophrenia vs Biploar Disorder 0.3 0.5 1.3 0.2 0.6 0.1 1.1 -1.0 0.1
Worry (Nagel 2018) 0.1 0.2 0.4 -0.4 0.3 0.1 -0.5 -0.2 0.7
Alzheimer’s Disease (in mother) 0.4 0.5 0.9 -0.4 -0.8 1.0 0.4 -1.0 -0.1
Alzheimer’s Disease (in father) 0.5 0.5 1.8 -0.2 -0.1 -0.8 -1.3 -0.7 -0.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.8 -0.5 0.1 -0.2 -0.4 -1.3 1.2
Crohns Disease (2017) 0.9 2.0 9.6 -0.1 -0.3 0.3 1.2 3.1 0.7
Irritable Bowel Disease (IBD) 0.9 2.0 10.2 0.3 -0.1 0.1 1.2 3.2 0.5
Ulcerative Colitis (UC) 0.6 1.1 5.2 0.4 0.1 -0.4 0.9 2.3 0.4
Major Depression (MDD) 0.9 1.1 5.4 -0.1 2.3 -0.5 0.2 -0.7 -0.7
Reaction Time 0.3 0.6 2.2 -1.5 0.4 -0.4 0.4 -0.9 0.0
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.5 -0.1 0.5 -0.6 -0.6 -0.7 -0.4
Breast Cancer 1.0 2.4 7.0 0.7 -0.6 0.8 2.6 0.7 2.4
Ovarian Cancer 0.2 0.3 0.6 0.6 -0.2 0.2 -0.1 -0.8 -0.7
Prostate Cancer 0.8 1.2 2.8 -0.7 0.0 1.7 1.2 1.4 -0.1
Age at First Birth 1.2 1.7 3.3 0.3 1.8 -1.1 -1.8 -1.2 -1.0
Bipolar Disorder (2011) 2.4 2.3 7.3 -1.4 0.8 -1.8 -2.7 0.2 -0.7
Body Mass Index (BMI) (2010) 0.4 0.5 1.6 -0.6 -0.9 -0.5 -0.2 1.3 0.4
Coronary Artery Disease (CAD) 1.1 1.4 6.1 0.4 1.2 -2.5 -0.6 -0.4 0.3
Crohns Disease (2012) 0.9 1.4 6.3 -1.0 -0.6 -0.2 -0.1 2.5 -0.9
Mean Putamen Volume 0.3 0.4 1.4 1.2 0.3 0.2 0.4 0.3 0.8
Fasting Glucose 0.2 0.3 0.7 -0.8 -0.6 0.7 0.1 0.2 -0.4
HbA1C 0.2 0.3 1.1 0.6 0.1 -0.1 1.0 0.1 0.2
HDL Cholesterol 0.2 0.4 0.9 0.3 1.0 -0.9 0.4 0.3 -0.5
LDL Cholesterol 0.7 1.1 2.4 1.1 1.3 1.1 0.5 -1.6 -0.4
Lupus 0.5 0.8 2.1 -0.8 0.6 -1.0 0.1 -1.5 -1.0
Neuroticism (2016) 0.8 1.2 3.6 -1.1 1.9 -1.2 0.3 -0.9 0.3
Primary Biliary Cirrhosis 0.8 1.1 3.5 -0.9 1.9 0.1 -1.4 0.4 -0.3
Rheumatoid Arthritis 0.4 0.5 2.2 -0.6 0.6 -0.5 0.1 1.5 0.1
Schizophrenia (2014) 1.0 2.1 6.7 1.7 -0.2 -2.6 -1.7 0.2 -0.5
Triglycerides 0.4 0.6 2.1 -1.0 -0.0 1.4 0.4 -0.0 0.7
Type 2 Diabetes (T2D) (2012) 0.6 0.6 2.2 0.0 0.5 -0.7 -1.5 -0.1 -1.0
Ulcerative Colitis 0.3 0.5 1.4 -0.8 -0.4 0.4 0.7 1.2 0.3
Blood Eosinophil Count 0.1 1.1 2.9 1.7 0.8 -0.3 -1.6 0.5 -0.0
Blood Platelet Count 1.2 13.5 49.3 2.4 -1.2 -4.0 -2.2 7.0 2.0
Blood Red Count 1.2 11.8 38.2 -1.1 1.3 -0.1 -5.2 -6.2 -1.7
Blood White Count 1.4 10.6 34.3 1.1 -2.0 -3.5 -3.5 5.9 -0.2
Heel T-Score 0.7 5.6 15.5 -1.7 0.7 3.9 3.8 -0.7 0.1
BMI 0.4 2.4 5.0 1.3 -1.5 -2.2 -1.0 2.1 0.2
Height 0.2 3.0 6.7 2.2 -0.8 2.6 0.5 0.5 2.3
Waist Hip Ratio (WHR) 0.5 2.4 10.8 -0.2 -1.2 -1.2 -3.3 0.6 0.3
Systolic Blood Pressure 0.6 3.1 5.3 -0.7 2.3 2.0 1.5 2.1 -1.3
Smoking Status 0.2 0.6 2.3 0.4 0.5 -1.5 -0.9 0.2 -0.2
Allergy or Eczema 0.9 2.3 11.6 -0.2 0.8 1.1 0.3 -0.3 -3.4
Cardiovascular Disease 0.7 2.2 8.3 -0.4 2.9 -0.7 0.5 -0.1 -2.0
Hypothyroidism (self reported) 0.4 1.0 2.5 1.5 0.3 -0.8 -0.1 0.6 1.6
Respiratory disease 0.3 0.8 1.8 -1.0 1.3 1.1 0.7 -0.3 -0.1
Type 2 Diabetes (T2D) (2018) 1.1 2.1 6.9 -0.4 0.6 -0.8 -2.6 -1.0 -1.9
Lung FEV1/FVC ratio 2.0 9.9 43.2 -0.2 -1.8 -1.2 1.2 6.6 3.2
Lung FVC 0.7 3.5 7.8 -0.1 -1.1 2.4 2.8 -2.3 -1.0
Neuroticism 0.4 0.9 2.9 -1.7 0.1 -0.1 -0.0 -0.8 1.3
Chronotype (morning person) 1.0 2.4 5.7 -1.5 2.4 0.1 1.5 1.3 -1.6
Hair Pigment 0.2 6.0 19.9 0.2 0.8 1.4 1.0 -3.5 -4.5
Tanning 0.3 3.1 6.2 2.1 1.5 -1.4 -1.0 2.5 1.7
Hand grip strength (left) 0.3 0.8 1.5 1.2 0.8 -0.1 0.2 -1.2 -1.1
Number of treatments/medications taken 0.5 0.8 1.9 1.0 0.7 -0.9 -1.4 -0.7 0.2
Average weekly spirits intake 2.1 2.6 3.8 0.8 -2.0 -1.7 -1.1 1.9 1.9
Sensitivity / hurt feelings 0.2 0.4 1.2 0.9 0.3 -1.1 0.0 -0.2 0.4
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.7 0.6 0.0 -0.1 -0.5 -0.1 0.9
Hearing difficulty/problems: Yes 0.7 1.0 3.0 -1.0 -0.5 0.1 -1.3 0.6 1.7
Relative age of first facial hair 1.7 3.5 9.5 -1.6 -0.7 -0.7 -0.3 -2.8 -3.1
Other serious medical condition/disability diagnosed by doctor 2.1 2.7 10.0 0.5 0.9 -2.0 -3.2 -0.2 1.0
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.6 -0.2 -0.2 -0.8 -1.3 -0.4 0.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.5 -0.9 1.0 -0.9 -1.2 0.4 -0.3
Systolic blood pressure, automated reading 0.8 2.3 6.6 -1.0 2.6 1.9 1.2 1.2 -0.1
Eye problems/disorders: Diabetes related eye disease 1.4 1.6 5.2 1.2 0.4 -1.5 -2.3 -0.6 0.3
Angina 0.9 1.2 4.2 -0.7 -0.6 -0.6 -0.6 -2.1 -1.0
Medication for hormone replacement therapy 0.5 0.5 1.3 -0.0 1.2 0.7 -0.0 -0.7 -1.0
Vitamin and mineral supplements 0.3 0.4 1.1 -1.1 -0.6 0.2 0.2 0.2 -0.8
Supplements: Zinc 0.9 0.9 2.7 1.7 1.0 0.2 0.9 0.9 -0.6
Medication: Co-codamol 1.2 1.4 3.7 -0.7 1.1 1.9 -0.4 1.4 0.9
Medication: Metformin 0.5 0.7 3.1 -0.0 -0.4 -0.5 -1.8 -0.8 -0.1
Diabetes (father) 1.3 1.5 7.0 -0.3 1.2 0.4 -0.6 0.5 2.6
Diabetes (mother) 0.3 0.3 1.4 -0.1 0.3 0.4 1.2 -0.6 0.2
Severe depression (siblings) 1.3 1.5 6.1 0.6 1.0 -0.1 -0.9 0.6 2.5
Pack years adult smoking proportion 0.8 1.2 2.7 -1.6 -0.9 -1.3 -0.8 0.5 -0.8
Impedance of leg (right) 0.2 0.7 2.3 -1.5 -0.1 0.7 -1.1 0.1 -0.7
Leg fat-free mass (left) 0.2 1.2 3.6 1.9 -1.5 -0.4 0.6 0.6 0.6
Trunk fat percentage 0.2 0.8 1.7 1.3 -1.1 0.5 -0.2 1.3 0.3
Hand grip strength (right) 0.2 0.4 1.8 -0.0 -0.0 -0.4 0.1 -1.4 -0.7
Townsend deprivation index at recruitment 1.2 1.7 3.8 1.6 1.9 0.1 -0.4 2.0 -0.6
Current tobacco smoking 0.3 0.5 2.3 0.4 0.1 -0.5 -0.3 1.5 -0.3
Average weekly fortified wine intake 0.4 0.5 1.4 0.5 -0.0 -0.0 0.1 1.1 1.2
Maternal smoking around birth 0.8 1.2 3.9 0.7 0.1 1.1 2.0 -1.1 -0.2
Fed-up feelings 0.4 0.7 1.9 -1.4 0.5 -0.6 0.7 -0.7 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.1 0.6 -0.4 -0.3 -0.3 -0.8 1.0
Relative age voice broke 2.2 3.4 9.9 -1.7 -0.0 -2.4 -0.9 0.8 -3.1
Taking other prescription medications 1.2 1.8 6.3 0.1 1.2 -1.3 -2.5 -1.1 0.4
Age when periods started (menarche) 0.6 1.6 3.9 0.0 -1.1 0.4 -2.0 -1.7 -1.1
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.1 -0.6 0.3 0.2 0.6 0.1 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 5.6 0.1 0.5 2.4 1.6 0.8 -0.6
Tinnitus: Yes, but not now, but have in the past 1.9 2.0 8.5 0.1 0.3 0.0 0.8 2.9 1.6
Qualifications: CSEs or equivalent 0.7 1.0 3.1 -1.8 0.6 1.0 -0.0 0.4 -1.1
Serious illness, injury or assault to yourself 1.1 1.3 5.6 2.4 -0.1 -0.4 -1.0 0.8 0.7
High blood pressure 0.4 1.1 4.3 -0.4 2.1 0.1 0.4 -0.2 -1.4
Hayfever, allergic rhinitis or eczema 1.1 2.5 9.7 -0.5 0.7 1.4 0.7 -1.4 -3.1
Multivitamins +/- minerals 0.2 0.2 0.5 0.2 0.6 -0.7 -0.0 -0.2 0.4
Stomach or abdominal pain in last month 1.1 1.3 3.5 0.4 1.7 -0.7 -1.9 -0.9 0.4
Supplements: Glucosamine 0.5 0.6 1.9 0.7 0.2 0.2 -0.1 1.1 1.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.1 -0.2 0.7 -1.4 -0.9 0.0 0.3
Medication: Atenolol 0.9 1.1 3.1 -1.1 1.2 0.3 0.6 -1.8 -0.6
Medication: Levothyroxine sodium 1.2 2.1 9.4 1.7 0.0 0.2 -0.3 -0.3 3.1
Sitting height 0.2 1.1 2.5 1.1 -1.6 0.7 0.5 -0.7 1.2
Chronic bronchitis/emphysema (father) 0.6 0.7 1.6 -0.5 0.3 -1.3 -1.2 0.5 0.7
High blood pressure (mother) 0.4 0.6 2.2 -0.4 0.2 0.7 1.5 -0.2 0.8
Body mass index (BMI) 0.3 1.2 2.5 1.6 -0.7 -1.3 -0.5 1.4 0.4
Impedance of leg (left) 0.2 1.0 3.0 -1.7 0.0 0.9 -1.3 -0.3 -0.8
Leg predicted mass (left) 0.2 1.2 3.4 1.9 -1.5 -0.4 0.7 0.7 0.5
Trunk fat mass 0.2 1.0 2.7 1.6 -1.3 0.3 -0.0 1.2 0.5
Waist circumference 0.5 1.8 4.5 1.7 -1.0 -1.2 -2.1 0.8 0.5
Number of incorrect matches in round 0.7 1.2 4.0 0.6 2.0 -0.0 -0.2 -1.4 0.9
Past tobacco smoking 0.5 0.9 3.4 -0.7 -0.9 0.6 0.6 0.4 -1.8
Alcohol usually taken with meals 0.5 0.8 1.9 0.9 -1.2 -1.4 -0.2 -0.4 0.3
Nervous feelings 1.0 1.8 5.6 -2.4 2.2 -0.2 -0.1 -0.8 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.9 0.7 1.2 -1.0 -0.8 0.4 1.4
Hearing difficulty/problems with background noise 0.7 1.1 2.3 0.7 1.3 -0.5 -1.4 -0.1 1.5
Hair/balding pattern: Pattern 2 0.2 0.2 0.8 -0.3 -0.9 -0.1 -0.2 0.6 0.1
Had menopause 0.8 1.0 3.2 1.8 -0.1 0.4 0.0 0.2 1.6
Had other major operations 0.3 0.3 0.7 -0.7 -0.4 0.1 0.0 -0.9 -0.8
Forced vital capacity (FVC) 1.0 3.9 8.5 0.3 -1.7 2.9 2.5 -2.2 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 8.3 -1.2 0.9 2.9 1.9 0.8 -0.4
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 3.3 -0.9 0.7 0.2 -1.8 1.2 1.4
Qualifications: None of the above 0.3 0.5 1.5 -0.8 1.2 0.5 -0.8 0.4 0.2
Financial difficulties in last 2 years 0.9 1.3 3.3 0.7 1.8 -1.1 0.4 1.2 1.0
Mouth/teeth dental problems 2.1 3.2 11.5 0.1 -2.1 -1.3 0.5 -1.1 -3.4
Heart attack 0.3 0.4 0.8 -0.8 -0.2 -0.4 -0.3 -0.9 -0.7
Allergy 0.5 1.1 3.8 -0.2 -1.1 -0.7 -0.1 1.0 1.9
Pain all over the body in last month 1.3 1.4 6.7 -0.3 -2.6 0.4 0.8 0.9 -0.2
Diabetes (self-reported) 0.6 1.0 3.0 -0.4 -0.3 0.5 -0.9 -1.2 -1.7
Hayfever/allergic rhinitis (self-reported) 1.1 1.4 3.3 0.6 0.1 1.8 1.2 -0.7 -1.7
Medication: Ramipril 0.1 0.1 0.3 -0.1 0.0 0.0 -0.3 -0.5 -0.3
Medication: Simvastatin 1.6 2.3 6.6 -2.1 0.8 0.9 2.6 -0.4 -1.0
Fluid intelligence score 0.4 0.8 1.9 -0.1 -0.8 -1.4 -0.1 -1.4 0.5
Illnesses of siblings 0.6 0.9 3.4 0.1 0.6 -0.8 -0.6 0.7 -1.8
Neuroticism score 0.4 0.8 2.5 -1.6 0.3 0.1 0.4 -0.9 1.2
Weight 0.3 1.4 4.3 2.1 -1.4 -0.5 -0.1 1.1 0.8
Impedance of arm (right) 0.2 1.2 3.7 -1.2 0.2 1.9 -0.0 0.7 -1.1
Arm fat percentage (right) 0.2 0.7 2.4 1.2 -0.6 0.1 -0.1 1.6 0.3
Trunk fat-free mass 0.2 1.1 3.6 1.9 -1.3 -0.4 0.3 -0.2 1.0
Hip circumference 0.2 0.9 2.5 1.6 -0.8 -0.9 -0.6 1.2 0.0
Time employed in main current job 1.8 2.1 8.3 2.9 0.3 -0.6 0.0 1.9 0.5
Alcohol intake versus 10 years previously 0.5 0.8 2.0 0.6 0.7 0.7 1.2 1.4 -0.5
Father’s age at death 1.2 1.5 6.2 -2.5 0.1 -0.2 -1.7 0.0 0.0
Worrier / anxious feelings 0.1 0.2 0.4 -0.1 0.6 -0.2 -0.6 0.5 -0.6
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 3.4 1.9 0.6 -0.1 0.3 -0.2 -0.6
Falls in the last year 0.4 0.6 1.6 -0.0 0.4 -1.2 -0.4 0.5 1.2
Hair/balding pattern: Pattern 3 0.6 0.9 2.8 -0.8 0.2 -0.2 0.3 -1.7 1.4
Number of live births 0.2 0.2 0.4 0.3 -0.6 0.3 -0.6 0.5 -0.3
Forced expiratory volume in 1-second (FEV1) 1.1 3.8 8.7 0.3 -2.6 2.7 3.0 0.2 -0.4
Pulse rate 0.2 0.4 1.8 1.3 -0.5 -0.0 -0.2 0.4 -0.0
Happiness 0.2 0.2 0.7 -0.9 0.2 -0.3 -0.4 0.1 -0.6
Noisy workplace 0.5 0.6 1.3 -0.6 1.0 0.3 -0.1 1.1 1.0
Qualifications: A levels/AS levels or equivalent 0.9 2.0 4.7 -0.7 -1.1 -0.0 2.1 -2.2 -1.1
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.1 2.7 1.0 -0.4 1.7 -1.2 0.6 -1.0
Mouth/teeth dental problems: Dentures 1.3 2.2 7.7 -0.4 1.7 1.1 -0.9 0.5 2.8
Asthma 0.6 1.1 3.8 -0.2 1.5 2.0 0.7 -0.5 0.3
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.9 -0.4 -1.0 -0.4 0.9 1.4 0.9
Medication: Cholesterol lowering 1.8 2.8 6.2 -2.3 1.5 -0.3 0.2 -1.8 -2.5
Depression (self-reported) 0.7 0.8 1.7 -1.1 0.6 -0.5 -0.9 -1.3 0.5
Medication: Lansoprazole 0.5 0.6 2.4 -0.5 -0.4 -0.3 -1.6 0.5 0.4
Prospective memory result 0.3 0.4 1.1 -1.1 -0.5 -0.3 0.4 -0.7 0.7
Lung cancer (father) 1.5 1.8 6.9 0.3 -0.3 -2.6 -1.8 0.4 -0.1
Illnesses of mother 1.0 1.2 3.4 0.2 0.0 -0.7 -1.8 1.8 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.2 3.8 11.3 0.4 -2.1 2.5 3.4 0.5 -0.6
Pulse wave Arterial Stiffness index 1.1 1.3 5.4 -0.0 -0.2 1.4 2.3 0.4 0.6
Impedance of arm (left) 0.3 1.3 3.5 -1.9 -0.4 1.9 0.4 -0.0 -0.6
Arm fat mass (right) 0.2 1.0 2.2 1.5 -1.3 -0.6 -0.2 1.2 0.6
Trunk predicted mass 0.2 1.1 3.5 1.9 -1.3 -0.3 0.4 -0.2 1.0
Standing height 0.2 1.6 4.2 1.2 -2.1 1.4 0.6 -0.6 1.1
Length of working week for main job 0.8 0.9 2.7 -0.4 -0.7 0.9 1.0 0.5 -1.6
Exposure to tobacco smoke at home 0.9 1.0 2.1 0.4 -0.6 1.0 1.4 1.4 0.6
Breastfed as a baby 0.5 0.7 2.8 0.7 -0.5 -0.1 -1.7 -0.6 0.1
Tense / ‘highly strung’ 0.7 1.1 3.0 0.2 1.2 -0.5 -1.4 -0.1 1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.5 -0.4 0.6 0.5 0.5 -0.7 0.1
Hair/balding pattern: Pattern 4 1.1 2.8 9.9 1.1 -0.9 1.9 0.8 -0.5 -3.2
Birth weight of first child 0.9 1.6 5.8 -0.4 1.3 -1.1 -2.4 0.6 -0.3
Peak expiratory flow (PEF) 0.3 0.7 2.2 -0.4 -1.5 1.0 0.4 -0.3 -0.9
Pulse wave reflection index 0.6 0.7 1.3 1.1 1.1 -0.6 0.8 -1.0 -0.3
Ever highly irritable/argumentative for 2 days 1.0 1.1 3.6 0.5 -0.3 -0.7 -1.5 1.9 0.4
Loud music exposure frequency 0.3 0.3 1.0 1.0 -0.0 -0.7 0.2 0.3 -0.7
Qualifications: O levels/GCSEs or equivalent 2.9 4.5 11.1 -0.5 -0.9 2.9 2.2 -3.3 -1.3
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 2.3 -0.0 1.4 1.5 0.7 0.1 1.5
Blood clot in the leg (DVT) 0.9 1.1 3.1 1.8 -0.6 -1.0 -1.4 0.3 0.4
Medication: Paracetamol 1.2 2.0 5.1 -0.5 0.6 1.4 2.3 1.9 0.9
Headache pain in last month 0.4 0.7 1.4 -0.7 0.7 1.2 1.0 0.5 -0.8
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 3.3 0.3 -1.5 0.6 -0.1 1.1 1.8
Glaucoma (self-reported) 1.5 1.8 5.4 -1.0 -0.5 1.3 2.3 -1.5 0.2
Gout (self-reported) 1.6 2.2 9.0 0.3 0.9 0.9 1.3 3.0 1.0
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 5.2 1.7 0.7 -0.8 -0.4 -0.7 2.3
Medication: Amlodipine 0.6 0.8 2.5 0.7 0.3 -1.0 0.1 0.9 -1.6
Medication: Ventolin 100micrograms inhaler 0.7 1.0 4.2 0.5 2.0 -0.4 -0.6 -0.9 -0.1
Birth weight 0.2 0.4 0.7 -0.4 0.6 -0.0 -0.6 -0.8 0.7
Chronic bronchitis/emphysema (mother) 1.0 1.2 2.3 -0.4 1.0 0.1 -1.5 -1.3 -1.4
High blood pressure (siblings) 0.3 0.4 1.9 -0.4 0.3 0.0 0.2 0.4 1.4
Forced vital capacity (FVC), Best measure 0.8 2.8 6.0 0.2 -1.5 2.3 2.4 -1.7 -0.7
Body fat percentage 0.2 0.8 2.1 1.3 -1.0 0.3 -0.3 1.5 0.5
Leg fat percentage (right) 0.3 1.2 4.2 1.2 -0.3 -0.6 -0.8 2.1 0.5
Arm fat-free mass (right) 0.2 1.1 2.8 1.7 -1.7 -0.3 0.4 -0.4 0.9
Exposure to tobacco smoke outside home 0.4 0.5 1.1 -0.7 0.5 -0.9 0.5 0.5 -1.0
Comparative body size at age 10 0.1 0.4 0.7 0.2 0.7 -0.8 0.8 0.8 -0.0
Number of full brothers 0.1 0.1 0.2 -0.4 0.4 -0.2 -0.1 0.3 -0.5
Worry too long after embarrassment 0.6 1.0 1.8 -1.3 -0.0 1.1 0.6 -1.3 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 3.7 -0.2 1.9 -0.5 -0.3 -0.9 0.7
Wheeze or whistling in the chest in last year 1.0 1.8 6.5 1.1 1.0 -1.5 -2.5 0.5 0.0
Number of children fathered 0.4 0.5 1.9 -0.9 0.4 0.0 0.2 1.4 0.2
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.4 6.7 0.1 0.5 2.6 2.5 0.7 1.0
Age at first live birth 0.3 0.6 2.0 -1.0 -0.6 -0.1 0.5 0.0 -1.4
Pulse wave peak to peak time 1.0 1.2 5.0 -0.1 -0.0 -1.5 -2.2 -0.3 -0.4
Health satisfaction 0.7 0.9 2.3 -0.6 0.1 -1.5 -1.0 -1.1 0.6
Shortness of breath walking on level ground 0.4 0.5 1.5 -0.6 0.8 0.1 -1.2 -0.6 -0.1
Qualifications: College or University degree 0.2 0.5 1.3 1.1 -0.5 -1.1 -0.1 -0.4 -0.1
Eye problems/disorders: None of the above 1.7 2.0 6.1 -0.0 0.9 1.7 1.0 2.5 0.9
Mouth/teeth dental problems: Loose teeth 0.9 1.0 2.3 1.1 0.4 1.5 -0.9 1.2 -0.3
Emphysema/chronic bronchitis 1.0 1.2 1.7 -1.3 1.3 0.2 0.5 1.3 1.3
Medication for pain relief, constipation, heartburn 0.4 0.7 1.8 0.2 0.7 0.8 0.3 -1.3 -1.1
Neck or shoulder pain in last month 0.6 0.9 1.9 0.5 1.1 -1.1 -0.9 0.1 1.4
Medication: Blood pressure 0.4 0.8 2.4 0.7 1.6 -0.3 -0.6 -0.7 -0.9
Angina (self-reported) 0.9 1.2 3.7 -0.6 -0.8 -0.6 -0.6 -1.9 -1.2
Migraine (self-reported) 0.0 0.1 0.1 0.2 -0.2 0.1 0.4 0.1 0.3
Medication: Ibuprofen 0.4 0.4 1.1 -0.3 0.1 -0.1 0.7 1.0 0.9
Medication: Allopurinol 2.6 3.4 17.9 0.5 0.4 0.6 0.8 4.2 1.2
Medication: Omeprazole 1.4 1.7 3.7 1.9 1.5 -1.5 -1.2 -0.1 0.4
Medication: Seretide 50 evohaler 1.3 1.5 7.9 -0.2 2.8 0.1 0.1 -0.1 -1.1
Mean time to correctly identify matches 0.3 0.6 1.4 -1.2 1.0 0.1 0.4 -0.8 0.6
Heart disease (mother) 1.7 2.1 7.3 -0.2 -0.7 2.1 2.7 -0.5 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.8 2.1 4.0 0.2 2.0 -1.4 -1.8 0.4 1.8
Whole body fat mass 0.2 1.0 2.0 1.4 -1.4 -0.2 -0.1 1.3 0.5
Leg fat mass (right) 0.3 1.3 3.3 1.7 -0.9 -0.7 -0.3 1.8 0.5
Arm predicted mass (right) 0.2 1.1 3.2 1.8 -1.3 -0.5 0.4 -0.1 1.1
Pulse rate, automated reading 0.1 0.4 0.9 0.5 -0.4 0.5 -0.0 0.8 -1.0
Alcohol intake frequency. 0.6 1.4 5.3 -1.0 0.1 2.3 1.2 -0.1 -0.8
Comparative height size at age 10 0.4 2.3 7.2 2.7 -1.8 1.0 0.8 -0.5 1.3
Number of full sisters 0.1 0.2 0.4 0.2 0.6 -0.3 -0.5 -0.2 -0.4
Suffer from ‘nerves’ 0.4 0.6 2.6 -0.2 1.6 0.1 0.8 -0.7 -0.2
Overall health rating 0.9 2.0 5.8 0.9 -0.6 -2.1 -2.4 -0.7 0.4
Chest pain or discomfort 1.7 2.4 8.8 0.8 -0.7 -2.1 -3.0 -0.4 0.4
Had major operations 1.1 1.3 2.7 -0.6 -1.6 -1.4 -1.0 -0.8 1.0
Age at last live birth 0.6 0.8 2.5 -0.3 -1.2 -0.6 -0.4 0.8 -1.6
Family relationship satisfaction 0.5 0.6 1.9 -0.5 -0.3 -0.9 -1.4 0.7 0.2
Leg pain on walking 1.5 1.8 5.7 0.4 -1.9 1.1 0.1 0.6 2.4
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.2 1.1 -0.7 -0.5 0.9 -1.0 -0.7
Commuting to job workplace: Car/motor vehicle 0.2 0.3 1.0 0.7 0.5 0.1 -0.1 0.2 -1.0
Illness, injury, bereavement, stress in last 2 years 0.8 0.9 3.9 -2.0 -0.5 -0.6 0.8 -0.4 -0.6
Medication: Aspirin 0.8 1.1 2.3 -0.5 -0.8 -1.2 -1.3 0.2 -1.5
Supplements: Vitamin C 0.3 0.3 0.7 0.8 -0.4 0.6 0.5 -0.3 0.7
Knee pain experienced in last month 1.7 2.7 12.6 0.8 -1.1 0.4 0.8 0.9 3.6
Hypertension (Self-reported) 0.3 1.0 4.0 -0.5 2.0 -0.0 0.5 -0.1 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.3 -1.0 1.5 -1.5 -1.3 -0.2 0.5
Illnesses of father: Heart disease 1.1 1.5 4.1 0.4 -1.7 -1.0 0.3 0.8 2.0
Illnesses of siblings: Diabetes 0.6 0.7 1.7 0.8 -1.1 -0.3 -0.6 -0.2 1.3
Smoking status: Previous 0.3 0.4 1.0 0.3 1.0 -0.2 -0.5 -0.4 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 3.2 0.2 -0.1 0.5 -1.0 -0.5 -1.8
Whole body fat-free mass 0.2 1.2 3.7 1.9 -1.5 -0.3 0.5 0.0 0.9
Leg fat-free mass (right) 0.2 1.0 3.1 1.8 -1.3 -0.3 0.7 0.4 0.5
Arm fat percentage (left) 0.2 0.7 1.8 0.9 -1.1 0.0 0.2 1.3 0.4
Average weekly red wine intake 0.2 0.3 0.9 -0.6 -0.2 -0.3 0.0 -0.9 -0.6
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.6 0.7 -1.6 -0.9 -0.6 -0.2 -1.1
Mood swings 0.7 1.3 3.5 -1.9 -0.1 -0.1 1.0 0.3 1.8
Loneliness, isolation 0.2 0.2 1.1 -0.2 0.1 0.2 -0.3 1.1 0.1
Long-standing illness, disability or infirmity 2.0 3.1 10.4 0.5 1.5 -2.0 -3.2 -1.3 0.4
Ever had bowel cancer screening 0.7 0.8 3.8 -0.6 -0.5 0.1 -0.2 -1.9 -0.7
Diabetes diagnosed by doctor 1.0 1.6 4.0 -0.1 -0.7 -0.1 -1.7 -1.4 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.1 0.7 0.1 1.4 0.3 -0.0 -1.5
Friendships satisfaction 0.7 0.9 4.6 -0.5 0.0 -2.1 -0.4 -0.4 -0.3
Qualifications: nursing, teaching 0.4 0.7 1.8 -0.4 -1.3 -0.5 0.1 -1.4 -0.1
Commuting to job workplace: Walk 0.7 0.7 2.0 0.6 1.1 1.4 0.6 0.4 0.4
Eye problems/disorders: Cataract 0.8 0.9 2.2 0.4 0.3 -0.5 -0.8 -1.5 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.5 0.9 3.9 0.8 0.2 -0.5 -0.2 0.4 2.0
Medication for cholesterol 0.6 0.9 2.1 0.8 -1.4 -0.9 -1.1 0.0 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 2.7 0.6 0.2 0.9 1.3 0.1 1.6
Back pain experienced in last month 0.6 0.9 2.5 0.9 -1.6 -0.1 -1.4 -0.1 0.3
Mineral and other dietary supplements 1.3 1.8 7.2 -2.7 0.9 0.0 1.3 -0.4 -0.9
Breast cancer (self-reported) 1.8 2.2 6.4 2.5 0.8 -0.8 -2.3 0.1 0.5
Asthma (self-reported) 0.5 1.0 3.2 -0.4 1.3 1.8 0.7 -0.6 0.2
Osteoporosis (self-reported) 0.8 1.0 2.6 -0.5 1.6 -0.5 -1.3 -0.5 -0.9
Osteoarthritis (self-reported) 0.1 0.1 0.2 -0.3 0.2 0.5 -0.2 -0.1 0.4
Medication: Aspirin 1.2 1.5 2.6 -1.3 -0.8 -1.4 -1.6 -0.4 -1.5
Medication: Gliclazide 0.3 0.3 1.1 -0.6 0.3 0.1 0.4 0.4 1.0
Illnesses of father: None of the above (group 1) 1.3 1.6 5.5 -0.1 1.2 1.0 0.9 -0.9 -2.3
Smoking status: Current 0.3 0.5 1.8 0.9 0.1 -0.4 -0.2 1.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.4 12.7 1.2 -0.0 2.5 3.6 0.6 0.2
Whole body water mass 0.2 1.1 3.5 1.9 -1.4 -0.3 0.5 0.2 0.9
Leg predicted mass (right) 0.2 1.0 3.3 1.8 -1.5 -0.3 0.6 0.5 0.4
Arm fat mass (left) 0.3 1.1 2.3 1.5 -1.4 -0.5 -0.0 1.3 0.6
Number of self-reported non-cancer illnesses 1.0 1.8 5.0 -1.1 2.2 -0.9 -1.3 -1.1 -0.7
Average weekly champagne plus white wine intake 1.0 1.3 2.8 -0.1 -1.7 -1.5 -1.2 0.3 1.2
Miserableness 0.6 1.0 2.8 -1.7 0.9 -1.3 0.1 -0.6 0.6
Guilty feelings 1.2 1.8 6.4 -2.5 1.3 0.2 0.2 -0.8 1.3
Wears glasses or contact lenses 0.6 0.6 2.2 -0.7 0.1 0.5 0.8 -0.6 1.5
Ever taken oral contraceptive pill 0.3 0.3 0.6 -0.3 -0.8 0.2 -0.5 0.7 -0.6
Hearing aid user 0.5 0.6 1.1 -0.4 -1.0 0.3 1.0 0.4 0.9
Mother’s age at death 0.4 0.5 1.6 -0.9 -0.1 1.3 -0.1 0.3 0.7
Financial situation satisfaction 0.9 1.1 2.6 -0.0 0.5 -1.6 -1.4 1.2 -0.5
Tinnitus: Yes, now most or all of the time 0.4 0.5 2.2 -0.7 0.2 1.5 0.4 0.1 -0.3
Commuting to job workplace: Public transport 0.3 0.3 0.9 -0.8 -0.2 -0.2 -0.2 -0.5 1.0
Eye problems/disorders: Glaucoma 1.7 2.1 3.7 -1.6 -0.2 1.8 1.9 -1.7 0.1
Medication: Blood pressure 0.5 0.9 2.7 -1.0 1.6 0.4 0.9 -0.4 -0.6
Pain type(s) experienced in last month: Hip pain 0.7 0.9 4.7 -0.6 0.0 -0.4 -0.3 2.2 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 3.4 1.4 -1.8 0.6 -0.0 0.5 0.3
High cholesterol (Self-reported) 1.3 2.3 6.6 -1.7 2.6 0.5 0.8 -1.6 -0.8
Medication: Bendroflumethiazide 0.2 0.3 0.8 0.3 0.7 0.4 -0.9 -0.0 0.3
Medication: Paracetamol 1.7 2.7 8.0 -0.6 0.5 1.7 2.8 1.7 1.3
Medication: Lisinopril 0.9 1.2 3.5 1.9 0.8 0.1 0.0 -1.7 0.1
Medication: Atorvastatin 1.1 1.4 3.7 -0.2 1.5 -0.4 -1.5 0.3 -1.9
Illnesses of father: High blood pressure 0.4 0.4 2.4 -1.6 -0.4 -0.1 0.2 0.1 -0.1
Alcohol drinker status: Never 0.4 0.5 1.4 -0.5 -1.2 0.5 0.6 -0.8 0.1
Ever smoked 0.5 0.8 4.0 0.4 -0.1 -0.7 -0.0 -0.2 2.0
Basal metabolic rate 0.2 1.2 3.9 2.0 -1.5 -0.4 0.4 0.3 1.0
Leg fat percentage (left) 0.2 0.8 2.6 1.2 -0.4 -0.4 -0.7 1.6 0.3
Arm fat-free mass (left) 0.2 1.2 3.7 1.9 -1.4 -0.8 -0.3 0.3 1.0
Number of operations (self-reported) 0.7 1.1 4.0 -0.6 -0.3 -2.0 -1.2 -0.3 0.5
Average weekly beer plus cider intake 0.2 0.3 0.6 -0.3 0.8 0.8 0.1 -0.6 -0.1
Irritability 0.8 1.4 6.9 -0.7 -0.4 -0.4 0.9 -0.1 2.6
Risk taking 0.7 1.1 2.3 -0.9 -1.3 1.1 1.5 0.6 -0.3
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.2 -0.8 0.2 1.5 1.5 -1.4 0.4
Fractured/broken bones in last 5 years 0.5 0.6 1.2 1.0 0.2 -0.8 -1.1 -0.3 -0.9
Age started oral contraceptive pill 0.5 0.7 2.0 -1.4 0.5 -0.5 -1.0 -0.8 0.2
Diastolic blood pressure, automated reading 0.4 1.1 2.7 -1.2 0.9 1.0 1.7 0.0 -0.6
Ever depressed for a whole week 1.2 1.5 4.5 -1.6 1.4 -0.1 -2.1 0.1 -0.2
Unable to work because of sickness or disability 0.5 0.6 1.7 -0.3 -1.2 -1.3 -0.2 0.0 -0.4
Commuting to job workplace: Cycle 0.7 0.9 2.0 -0.1 -0.3 1.4 -1.1 -1.2 0.7
Myopia 0.8 1.2 2.2 -0.7 -1.5 -1.3 0.0 1.3 -1.2
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.2 0.1 -2.1 0.6 0.2 0.6 1.7
Cholesterol lowering medication 0.3 0.5 1.1 -0.4 0.8 1.0 0.8 0.3 -0.6
Medication: Omeprazole (e.g. Zanprol) 2.0 2.4 4.1 2.0 1.7 -1.6 -2.0 -0.5 0.8
Pain experienced in last month 1.0 1.7 4.2 -0.8 -1.0 1.6 2.1 -0.9 -1.0
Supplements: Calcium 1.0 1.1 2.9 1.4 -0.6 -0.8 -1.7 -0.1 -0.7
Basal cell carcinoma (self-reported) 0.3 0.4 0.6 -0.4 -0.2 -0.8 -0.8 -0.5 0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.8 -0.9 -0.5 -0.4 -0.4 -0.9 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.1 3.3 1.8 -0.3 -0.9 -1.4 0.2 0.4
Heart disease (siblings) 0.5 0.7 3.2 0.1 0.7 0.4 1.8 -0.2 0.0
Alcohol drinker status: Previous 0.3 0.4 1.0 -0.5 1.0 0.9 0.4 -0.1 0.4
Pack years of smoking 0.6 0.8 2.1 -1.4 -0.9 -0.9 -0.8 0.7 -0.4
Impedance of whole body 0.2 1.2 3.6 -1.9 -0.1 1.7 -0.5 -0.2 -0.8
Leg fat mass (left) 0.3 1.2 2.7 1.6 -1.1 -0.7 -0.4 1.5 0.5
Arm predicted mass (left) 0.2 1.1 4.3 2.1 -1.1 -0.5 0.1 0.2 1.0