TWAS hub - RALBP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.107	0.0320	2.2e-04	0.012	0.043	0.011	0.035	0.018	1.3e-02	5.6e-06	1.6e-02	4.0e-05	2.8e-03
2	GTEx	Esophagus Mucosa	0.164	0.0520	6.5e-04	0.114	NA	0.100	NA	0.114	4.8e-08	NA	3.2e-07	NA	5.2e-08
3	GTEx	Whole Blood	0.344	0.0500	8.7e-15	0.212	NA	0.188	NA	0.209	2.4e-19	NA	4.1e-17	NA	5.1e-19
4	NTR	Blood	0.117	0.0188	0.0e+00	0.084	0.087	0.087	0.078	0.084	1.1e-25	9.8e-27	1.7e-26	4.5e-24	1.2e-25
5	YFS	Blood	0.238	0.0263	0.0e+00	0.225	0.259	0.286	0.266	0.286	5.2e-72	3.1e-84	1.7e-94	5.1e-87	1.5e-94

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Hair/balding pattern: Pattern 2	4.6	5.8	9.9	1.7	1.1	3.1	2.4	3.1
LDL Cholesterol	3.8	6.0	13.9	3.7	2.9	1.6	1.1	2.0
Schizophrenia vs Biploar Disorder	3.7	4.8	9.5	1.7	0.7	2.5	3.1	2.2
Mouth/teeth dental problems: Dentures	3.4	5.8	8.9	-2.6	-1.5	-3.0	-2.2	-2.5
Medication: Blood pressure	3.4	5.9	9.5	-2.1	-1.8	-2.9	-2.0	-3.1
Supplements: Calcium	3.4	3.7	6.3	-1.5	-1.7	-2.5	-1.4	-2.2
Schizophrenia (2018)	3.2	6.6	10.2	2.5	0.6	2.8	3.2	2.9
Schizophrenia (2014)	3.2	7.1	10.6	2.4	0.5	3.0	3.2	3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	6.2	-1.6	0.0	-2.1	-2.5	-2.4
Pain experienced in last month	3.2	5.4	12.7	3.6	3.5	-0.4	-1.3	0.5
Illnesses of siblings: Diabetes	3.0	3.7	12.7	-2.3	-3.6	0.3	-0.1	0.2
Qualifications: CSEs or equivalent	2.8	3.8	8.0	-0.6	1.4	-2.7	-1.0	-2.8
Number of treatments/medications taken	2.6	4.7	8.9	-2.7	-3.0	-1.8	-1.0	-1.8
Medication for hormone replacement therapy	2.6	2.9	6.9	-0.1	-1.1	1.9	2.6	1.6
Medication for pain relief, constipation, heartburn	2.6	4.4	12.5	3.5	2.8	0.3	0.5	1.2
Illnesses of siblings	2.5	3.5	8.6	2.4	2.9	1.1	1.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	2.5	3.0	10.2	1.7	3.2	0.7	0.3	1.1
Financial situation satisfaction	2.5	3.1	5.2	-2.1	-2.3	-1.4	-0.8	-1.7
Mean Putamen Volume	2.4	2.8	3.9	-0.4	-1.8	1.9	1.6	2.0
Hearing difficulty/problems: Yes	2.4	3.6	10.3	-2.4	-3.2	-0.8	-0.0	-1.2
Taking other prescription medications	2.4	3.7	5.2	-1.7	-1.1	-2.2	-2.3	-2.2
Qualifications: nursing, teaching	2.3	3.5	6.3	1.1	-0.0	2.5	2.3	2.2
Medication: Omeprazole (e.g. Zanprol)	2.3	2.8	4.9	-1.9	-2.0	-0.8	-2.2	-0.9
Osteoarthritis (self-reported)	2.2	2.9	3.9	-1.9	-0.7	-1.8	-2.0	-1.8
Blood Platelet Count	2.1	24.3	56.3	-7.5	-2.2	-4.3	-2.6	-5.8
Medication: Co-codamol	2.1	2.5	6.9	-2.6	-1.6	-1.2	-0.4	-1.1
Medication: Metformin	2.1	3.0	6.3	-1.2	0.0	-2.0	-1.8	-2.5
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	7.7	-2.2	-2.8	0.5	0.5	-0.3
Headache pain in last month	2.1	3.7	8.4	-2.9	-2.5	-1.1	-0.2	-1.7
Shortness of breath walking on level ground	2.1	2.5	3.8	-2.0	-1.3	-1.5	-1.1	-1.9
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	5.7	-1.4	-1.4	-1.8	-1.9	-2.4
Alzheimer’s Disease (including proxy)	2.0	2.9	9.7	-3.1	-1.4	-0.5	-1.1	-1.0
Alzheimer’s Disease (in mother)	1.9	2.2	6.5	-2.5	-2.0	0.1	-0.6	-0.3
Happiness	1.8	2.2	7.1	-2.7	-1.1	-1.0	-0.1	-1.3
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	3.5	0.4	1.6	1.9	1.6	1.6
Qualifications: College or University degree	1.8	5.6	12.8	1.0	-0.2	3.3	1.8	3.6
Age at last live birth	1.8	2.6	5.4	-0.6	-1.1	2.3	1.7	1.7
Illnesses of father: None of the above (group 1)	1.8	2.2	5.5	0.6	0.6	1.7	2.3	1.3
Medication: Ibuprofen	1.7	2.1	4.9	-2.2	-1.4	-1.0	-0.3	-1.5
Bipolar Disorder or Schizophrenia	1.6	3.8	6.5	1.6	0.3	2.1	2.3	2.5
Lupus	1.6	2.5	3.9	1.0	0.9	2.0	1.7	1.9
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	4.3	-1.4	-2.1	-0.6	-1.1	-0.9
Hearing difficulty/problems with background noise	1.6	2.6	8.2	-1.8	-2.9	-0.7	-0.4	-0.8
Comparative body size at age 10	1.6	4.4	6.3	-1.9	0.3	-2.5	-2.5	-2.4
Medication: Aspirin	1.6	2.1	6.3	-2.5	-1.2	-0.9	0.4	-1.4
Medication: Atorvastatin	1.6	1.9	2.9	1.7	0.1	1.7	1.1	1.7
Fasting Glucose	1.5	1.8	4.2	-1.2	-0.5	-1.8	-0.5	-2.0
Sensitivity / hurt feelings	1.5	2.5	8.2	2.9	1.6	-0.7	-1.1	-0.3
Had menopause	1.5	1.9	2.6	-1.1	-1.2	-1.4	-1.4	-1.6
Diabetes (self-reported)	1.5	2.3	5.5	-0.8	-0.4	-2.0	-1.0	-2.4
Loud music exposure frequency	1.5	1.6	2.3	0.7	-1.1	1.4	1.5	1.5
Pulse wave peak to peak time	1.5	1.8	3.0	-1.7	-1.7	-0.8	-1.0	-1.2
Emphysema/chronic bronchitis	1.5	1.7	3.8	-1.1	-2.0	-0.7	-0.0	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	5.6	-2.4	-1.3	-0.8	0.0	-1.0
Medication: Aspirin	1.5	2.0	5.9	-2.4	-1.3	-0.7	0.4	-1.2
Knee pain experienced in last month	1.5	2.3	6.3	-2.5	-1.6	1.2	1.1	0.5
Severe depression (siblings)	1.4	1.6	2.6	-1.6	-1.5	1.4	0.9	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.4	1.6	2.6	1.5	1.0	1.6	0.6	1.5
Migraine (self-reported)	1.4	1.7	4.1	-1.8	-2.0	0.6	0.7	0.5
Family relationship satisfaction	1.4	1.7	3.2	-1.4	-1.5	0.8	1.8	0.4
Ever had bowel cancer screening	1.4	1.7	3.0	-1.2	-1.0	1.7	1.0	1.3
Leg fat-free mass (left)	1.3	7.0	11.6	-2.4	-2.6	-2.7	-1.8	-3.4
Impedance of leg (left)	1.3	6.2	12.2	1.8	2.1	2.6	2.1	3.5
Leg predicted mass (left)	1.3	7.0	11.8	-2.4	-2.7	-2.7	-1.8	-3.4
Pain all over the body in last month	1.3	1.4	4.4	-2.1	-1.4	0.3	0.5	-0.3
Alcohol intake versus 10 years previously	1.3	1.9	3.5	-1.7	0.3	-1.3	-1.2	-1.9
Pulse wave Arterial Stiffness index	1.3	1.5	2.5	1.6	1.3	0.8	1.1	1.1
High blood pressure (siblings)	1.3	1.8	4.0	-2.0	-1.8	-0.6	-0.9	-0.7
Leg fat-free mass (right)	1.3	7.0	10.6	-2.7	-2.7	-2.6	-1.7	-3.3
Loneliness, isolation	1.3	1.7	6.9	-1.3	-2.6	0.2	0.2	0.1
Leg predicted mass (right)	1.3	7.2	11.0	-2.7	-2.7	-2.6	-1.7	-3.3
Irritability	1.3	2.2	3.8	0.5	1.7	-1.9	-0.8	-1.9
Intelligence (Savage-Jansen 2018)	1.2	3.8	8.0	2.4	1.6	-1.6	-2.8	-0.4
Major Depression (MDD)	1.2	1.5	4.0	-2.0	0.5	-0.9	-0.7	-1.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.5	2.1	-0.3	-1.4	1.4	1.3	1.4
Hip circumference	1.2	5.2	9.5	-2.4	-1.5	-2.6	-1.4	-3.1
Qualifications: O levels/GCSEs or equivalent	1.2	1.8	6.6	2.6	0.2	0.5	0.6	1.4
Arm fat-free mass (right)	1.2	6.1	9.7	-2.2	-1.8	-2.6	-2.4	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.5	3.8	-2.0	-0.6	-0.5	1.5	-1.0
Medication: Omeprazole	1.2	1.4	3.3	-1.1	-1.8	-0.0	-1.6	-0.1
Arm predicted mass (right)	1.2	6.2	10.5	-2.0	-1.5	-2.8	-2.5	-3.2
Alcohol intake frequency.	1.2	2.8	4.6	-1.2	-2.1	-2.0	-0.5	-2.0
Average weekly red wine intake	1.2	1.8	3.8	-0.9	-0.2	1.6	1.9	1.2
Medication for cholesterol	1.2	1.8	5.5	-1.0	0.5	-1.2	-2.3	-0.9
Depression (Nagel 2018)	1.1	1.6	3.5	-0.5	-1.0	1.7	1.9	0.9
Alzheimer’s Disease (in father)	1.1	1.1	2.7	-1.6	-1.5	-0.6	-0.5	-0.5
HbA1C	1.1	1.2	3.2	1.8	1.0	-1.0	-0.8	-0.6
Blood White Count	1.1	7.8	13.6	-2.4	-0.9	-3.7	-2.3	-3.7
Ever used hormone-replacement therapy (HRT)	1.1	1.3	2.2	-1.2	-1.2	-1.1	-0.7	-1.5
Impedance of leg (right)	1.1	5.1	9.3	2.0	2.1	2.2	1.7	3.1
Townsend deprivation index at recruitment	1.1	1.6	3.0	-1.7	-1.2	-1.4	-0.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.3	-1.8	-1.2	-0.9	-0.8	-1.5
Noisy workplace	1.1	1.4	2.7	-0.2	0.3	-1.5	-1.6	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	4.8	-2.2	-1.4	0.0	0.8	-1.2
Eye problems/disorders: None of the above	1.1	1.3	3.6	1.2	1.9	0.7	0.5	0.8
Hypertension (Self-reported)	1.1	3.0	4.7	-2.0	-1.8	-1.6	-0.4	-2.2
Whole body fat-free mass	1.1	6.5	10.5	-2.3	-2.3	-2.6	-2.1	-3.2
Whole body water mass	1.1	6.5	11.0	-2.2	-2.2	-2.7	-2.1	-3.3
Basal metabolic rate	1.1	6.2	10.3	-2.3	-2.3	-2.5	-1.9	-3.2
Number of operations (self-reported)	1.1	1.7	6.0	2.5	-0.2	1.0	0.3	1.1
Ulcerative Colitis (UC)	1.0	1.8	5.9	-1.3	-2.4	-0.3	-0.9	-0.7
Respiratory disease	1.0	2.2	3.4	-1.8	-1.8	1.4	1.4	0.8
Diabetes (father)	1.0	1.2	4.4	0.7	0.9	-0.7	-2.1	-0.2
Serious illness, injury or assault to yourself	1.0	1.2	2.0	-0.0	1.1	-1.2	-1.2	-1.4
High blood pressure	1.0	2.7	4.7	-1.9	-1.4	-1.7	-0.8	-2.2
Stomach or abdominal pain in last month	1.0	1.3	4.7	-0.8	-2.2	0.6	0.4	0.7
Number of incorrect matches in round	1.0	1.6	2.9	1.0	1.7	1.4	1.0	1.0
Neuroticism score	1.0	2.0	3.2	0.4	1.3	-1.8	-1.4	-1.7
Weight	1.0	5.0	8.5	-2.3	-2.4	-2.1	-1.0	-2.9
Number of live births	1.0	1.4	2.6	0.1	-0.5	-1.4	-1.5	-1.6
Qualifications: A levels/AS levels or equivalent	1.0	2.3	5.9	0.4	0.7	1.8	1.2	2.4
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	3.6	-1.9	-1.3	-0.6	-0.2	-0.9
Depression (self-reported)	1.0	1.2	4.9	-2.2	0.4	-0.4	0.2	-1.0
Birth weight of first child	1.0	1.8	6.4	2.5	1.2	0.3	0.5	0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.1	1.2	1.8	0.2	-1.1	0.4
Neck or shoulder pain in last month	1.0	1.5	3.2	-1.1	-1.1	1.8	0.7	1.1
Eye problems/disorders: Glaucoma	1.0	1.2	2.3	0.1	-0.6	-1.5	-1.3	-1.3
Ever depressed for a whole week	1.0	1.2	3.0	-1.7	-1.4	0.6	0.5	-0.6
Basal cell carcinoma (self-reported)	1.0	1.1	2.3	0.1	-1.1	1.2	1.5	0.8
Arm predicted mass (left)	1.0	5.1	8.8	-2.2	-2.0	-2.3	-1.7	-3.0
Verbal and Numeric Reasoning (VNR)	0.9	2.1	5.6	1.9	0.5	-1.0	-2.4	0.1
Body Mass Index (BMI) (2010)	0.9	1.2	3.1	-1.1	-0.4	-1.1	-0.5	-1.8
Rheumatoid Arthritis	0.9	1.2	1.7	0.8	0.9	1.3	1.0	1.3
Average weekly fortified wine intake	0.9	1.0	1.5	-0.9	-0.4	-1.2	-1.0	-1.2
Age when periods started (menarche)	0.9	2.1	2.8	-0.3	-1.6	1.7	1.6	1.6
Trunk fat mass	0.9	3.7	6.5	-2.2	-2.0	-1.8	-0.4	-2.5
Waist circumference	0.9	3.3	6.0	-1.7	-2.5	-1.5	-0.6	-2.2
Alcohol usually taken with meals	0.9	1.5	2.7	-0.5	-0.6	-1.6	-1.5	-1.4
Nervous feelings	0.9	1.7	2.7	1.2	1.0	-1.6	-1.7	-0.9
Trunk fat-free mass	0.9	5.3	8.6	-2.0	-1.9	-2.4	-2.1	-2.9
Trunk predicted mass	0.9	4.9	8.0	-1.9	-1.9	-2.2	-2.1	-2.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.2	-1.0	-1.1	-0.7	0.8	-1.5
Number of full brothers	0.9	1.1	1.7	1.0	1.3	1.1	0.3	1.2
Suffer from ‘nerves’	0.9	1.5	4.2	1.2	2.1	-0.8	-0.7	-0.7
Diabetes diagnosed by doctor	0.9	1.5	3.8	-1.1	-0.6	-1.4	-0.1	-2.0
Breast cancer (self-reported)	0.9	1.0	1.3	1.2	1.1	1.1	0.9	0.7
Arm fat-free mass (left)	0.9	4.6	7.7	-2.1	-1.8	-2.1	-1.7	-2.8
Ulcerative Colitis	0.8	1.2	4.2	-0.8	-2.0	0.9	-0.1	0.5
Ever had hysterectomy (womb removed)	0.8	0.9	3.7	1.9	0.8	-0.0	0.3	-0.3
Maternal smoking around birth	0.8	1.2	1.8	0.2	1.3	1.3	1.3	0.8
Chronic bronchitis/emphysema (father)	0.8	0.9	2.1	-0.3	0.0	-1.5	-0.7	-1.4
Had other major operations	0.8	1.0	4.6	2.1	-0.1	0.4	-0.1	0.6
Fluid intelligence score	0.8	1.7	4.0	1.6	-0.4	-1.3	-2.0	-0.1
Prospective memory result	0.8	1.0	1.8	-0.9	-0.9	1.1	1.3	0.3
Glaucoma (self-reported)	0.8	0.9	1.9	0.2	-0.5	-1.2	-1.0	-1.4
Gout (self-reported)	0.8	1.2	3.0	0.7	-0.1	1.5	0.4	1.7
Heart disease (mother)	0.8	1.0	2.2	0.0	1.4	-1.5	-0.0	-1.0
Number of full sisters	0.8	1.0	3.5	-1.9	-0.9	0.4	-0.3	0.6
Medication: Paracetamol	0.8	1.2	4.2	-1.1	-2.0	-0.0	-0.4	-0.8
Diastolic blood pressure, automated reading	0.8	2.4	3.7	-0.9	-1.9	-1.8	-0.9	-1.9
Myopia	0.8	1.2	2.0	-1.3	0.5	-1.1	-1.0	-1.4
Primary Biliary Cirrhosis	0.7	1.0	1.4	1.2	1.1	1.0	0.8	1.0
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.4	0.6	0.4	-1.1	-1.2	-0.8
Diabetes (mother)	0.7	0.9	1.6	-1.3	-1.2	-0.1	0.8	-0.7
Impedance of arm (right)	0.7	3.1	6.4	0.5	-0.8	1.8	2.5	2.2
Father’s age at death	0.7	0.9	2.7	-1.6	-0.9	-0.3	-0.7	-0.5
Worrier / anxious feelings	0.7	1.3	3.4	-0.1	0.1	-1.3	-1.8	-1.2
Asthma	0.7	1.3	2.9	-0.3	-0.0	1.7	0.8	1.7
Medication: Cholesterol lowering	0.7	1.0	2.2	1.5	0.1	0.7	1.2	1.0
Arm fat mass (right)	0.7	2.7	5.3	-1.7	-1.7	-1.5	-0.4	-2.3
Hair/balding pattern: Pattern 4	0.7	1.6	4.4	-1.1	-2.1	-0.6	-0.5	-1.4
Pulse wave reflection index	0.7	0.9	1.3	-0.9	0.9	1.1	1.0	0.8
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.2	0.6	1.0	1.5	0.4	1.4
Number of children fathered	0.7	0.8	2.4	-0.9	-1.6	0.8	0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.9	2.3	-0.0	-0.4	1.1	1.5	0.7
Age at first live birth	0.7	1.3	2.5	-0.6	-0.4	1.5	1.6	1.0
Mean time to correctly identify matches	0.7	1.3	2.7	-1.6	-1.6	0.5	0.9	0.0
Arm fat mass (left)	0.7	2.8	6.2	-1.4	-1.5	-1.8	-0.5	-2.5
Wears glasses or contact lenses	0.7	0.8	1.8	-0.9	-1.3	0.5	1.0	0.3
Fractured/broken bones in last 5 years	0.7	0.8	1.4	-0.0	0.6	-1.2	-1.1	-1.2
Unable to work because of sickness or disability	0.7	0.9	2.6	-0.6	-0.4	0.9	1.6	0.6
Impedance of whole body	0.7	3.7	7.5	1.2	0.7	2.0	2.3	2.7
Coronary Artery Disease (CAD)	0.6	0.7	3.1	-0.4	-0.3	0.5	1.8	0.1
Triglycerides	0.6	0.9	2.4	-0.2	0.9	-0.9	-1.6	-0.7
Allergy or Eczema	0.6	1.6	4.4	0.3	-2.1	1.3	0.5	1.3
Chronotype (morning person)	0.6	1.4	3.7	-1.9	-0.7	-0.1	1.3	-1.0
Frequency of depressed mood in last 2 weeks	0.6	0.9	1.8	-0.8	-1.0	0.9	1.3	0.2
Systolic blood pressure, automated reading	0.6	1.8	2.9	-0.7	-1.2	-1.7	-1.1	-1.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.3	1.1	0.2	-1.0	-0.2	-1.1
Falls in the last year	0.6	0.8	1.5	0.2	-1.2	1.0	0.8	1.0
Illnesses of mother	0.6	0.7	1.4	0.8	0.9	1.2	0.1	0.9
Breastfed as a baby	0.6	0.7	1.7	-0.8	-0.7	-0.6	-1.3	-0.7
Exposure to tobacco smoke outside home	0.6	0.9	1.5	-1.2	0.3	-0.8	-1.1	-0.9
Health satisfaction	0.6	0.7	1.9	-1.4	-1.1	-0.2	0.3	-0.7
Medication: Seretide 50 evohaler	0.6	0.7	1.3	0.4	-0.8	-1.1	-1.1	-0.7
Whole body fat mass	0.6	2.4	5.1	-1.6	-1.4	-1.5	-0.3	-2.3
Leg fat mass (right)	0.6	2.2	5.4	-1.3	-0.9	-1.7	-0.6	-2.3
Comparative height size at age 10	0.6	3.4	6.8	-2.6	-1.9	-1.3	-1.5	-1.7
Smoking status: Previous	0.6	0.9	3.6	-1.9	-0.1	0.1	0.2	-0.8
Eye problems/disorders: Cataract	0.6	0.7	2.7	-0.2	-1.6	0.6	-0.2	0.7
Guilty feelings	0.6	0.9	1.5	0.1	0.7	-1.1	-1.1	-1.2
Commuting to job workplace: Cycle	0.6	0.7	2.3	-1.1	-1.5	-0.1	-0.3	0.0
Vascular/heart problems diagnosed by doctor	0.6	1.7	2.7	1.7	1.6	1.0	0.3	1.5
Alcohol drinker status: Previous	0.6	0.6	1.8	0.2	-0.5	-1.3	-0.3	-1.1
Neuroticism (2016)	0.5	0.7	1.3	0.3	-0.9	-0.7	-0.8	-1.2
Systolic Blood Pressure	0.5	2.6	5.0	-1.4	-1.4	-2.0	-0.4	-2.2
Relative age of first facial hair	0.5	1.0	4.0	-1.0	-2.0	-0.1	-0.4	-0.2
Trunk fat percentage	0.5	1.9	3.0	-1.7	-1.5	-1.1	0.3	-1.7
Fed-up feelings	0.5	0.9	2.7	-1.7	-0.3	-0.8	-0.4	-1.0
Supplements: Glucosamine	0.5	0.6	1.7	-1.3	-0.8	0.5	0.8	-0.1
Medication: Levothyroxine sodium	0.5	0.8	1.3	-0.2	0.6	-1.1	-1.0	-1.1
Body mass index (BMI)	0.5	1.9	4.8	-1.3	-1.0	-1.4	-0.5	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	1.4	-1.1	0.2	1.1	1.2	0.5
Mouth/teeth dental problems	0.5	0.7	2.3	1.5	0.5	0.6	-0.1	0.8
Allergy	0.5	1.2	1.9	-0.6	1.4	-1.3	-1.0	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	3.1	-0.8	-1.3	-1.8	-1.1	-1.4
Medication: Lansoprazole	0.5	0.6	1.2	-0.8	-0.3	-0.7	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.7	3.7	-0.9	-0.8	-1.9	-0.7	-1.7
Medication: Paracetamol	0.5	0.8	2.9	-0.8	-1.7	0.2	-0.5	-0.3
Birth weight	0.5	1.0	2.6	-1.6	-1.4	0.1	0.8	-0.2
Wheeze or whistling in the chest in last year	0.5	0.9	1.2	-1.1	-1.1	-0.9	-0.5	-1.1
Pulse rate, automated reading	0.5	1.5	3.4	0.4	-1.2	-1.8	-0.7	-1.5
Leg pain on walking	0.5	0.6	2.6	-1.6	0.2	0.5	-0.3	-0.1
Supplements: Vitamin C	0.5	0.5	1.4	-0.2	-1.2	-0.6	0.8	-0.5
Medication: Gliclazide	0.5	0.6	1.4	1.2	0.6	-0.7	0.1	-0.8
Number of self-reported non-cancer illnesses	0.5	0.8	1.5	-1.2	-1.2	-0.5	-0.1	-0.9
Hearing aid user	0.5	0.5	0.8	0.7	-0.6	0.5	0.9	0.9
Commuting to job workplace: Public transport	0.5	0.6	1.3	1.1	0.8	-0.0	1.1	-0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.5	-1.2	0.1	-0.7	0.0	-1.1
Medication: Lisinopril	0.5	0.6	1.3	0.6	0.4	-1.1	-0.0	-1.1
Alcohol drinker status: Never	0.5	0.6	1.9	-0.2	-1.4	0.2	0.8	0.4
Cholesterol lowering medication	0.5	0.7	2.7	0.7	-0.0	0.6	1.6	0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.6	0.6	-0.1	-1.0	-0.3	-1.3
Leg fat mass (left)	0.5	1.8	4.6	-1.2	-0.8	-1.5	-0.4	-2.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.4	-1.5	-0.7	0.0	1.0	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	3.8	-0.6	-1.9	0.0	-0.3	-0.6
Reaction Time	0.4	0.7	2.2	-1.0	-1.5	0.3	0.4	0.1
Crohns Disease (2012)	0.4	0.7	1.7	-1.3	-1.1	-0.1	0.1	-0.6
BMI	0.4	2.1	4.9	-1.3	-1.2	-1.4	-0.8	-2.2
Cardiovascular Disease	0.4	1.2	3.1	-1.0	-0.4	-1.3	-0.4	-1.8
Hypothyroidism (self reported)	0.4	1.0	2.9	-1.7	-0.9	-0.7	-0.3	-0.8
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.5	-0.0	-0.9	0.3	1.2	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	1.0	-0.6	-0.2	-1.0	0.3	-1.0
Hand grip strength (right)	0.4	1.1	2.5	-1.1	-1.6	-0.4	-1.3	0.0
Relative age voice broke	0.4	0.6	2.5	-0.3	-1.6	-0.5	-0.5	-0.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	1.7	1.3	-1.1	0.7	0.3	0.9
Sitting height	0.4	2.8	10.1	-1.6	-3.2	-0.7	0.3	-0.9
High blood pressure (mother)	0.4	0.5	0.9	-0.7	-0.6	-0.9	0.1	-1.0
Medication: Simvastatin	0.4	0.5	1.5	1.2	0.2	-0.2	1.0	-0.3
Pulse rate	0.4	0.6	1.2	0.6	-0.4	-0.9	-1.1	-0.8
Standing height	0.4	4.3	8.9	-2.2	-3.0	-1.7	-1.2	-1.9
Blood clot in the leg (DVT)	0.4	0.6	1.5	0.5	0.2	-1.0	-0.1	-1.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.6	-0.6	0.2	-1.3	-0.8	-1.0
Worry too long after embarrassment	0.4	0.6	1.0	0.9	1.0	-0.4	-1.0	0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.2	1.1	0.7	-0.4	0.2	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	0.2	-1.3	0.8	1.0	0.9
Arm fat percentage (left)	0.4	1.5	3.8	-0.8	-1.0	-1.4	-0.1	-1.9
Commuting to job workplace: Walk	0.4	0.4	1.5	1.2	-0.4	0.4	0.5	0.3
Asthma (self-reported)	0.4	0.8	1.8	-0.2	0.0	1.3	0.7	1.3
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.3	-0.2	-1.0	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.9	0.8	0.6	-1.4	-0.9	-0.9
Average weekly champagne plus white wine intake	0.4	0.6	2.0	0.0	-0.6	0.5	1.4	0.5
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	-0.0	-0.5	0.6	0.7	1.1
Illnesses of father: High blood pressure	0.4	0.4	0.7	0.8	-0.2	-0.6	-0.8	-0.7
Age started oral contraceptive pill	0.4	0.6	2.0	0.9	-1.4	0.2	0.1	0.1
Breast Cancer	0.3	0.6	1.5	-0.6	-0.9	-0.5	-1.2	-0.5
Ovarian Cancer	0.3	0.4	1.2	0.5	-0.4	0.2	-1.1	0.6
Blood Red Count	0.3	2.7	4.3	-1.4	-1.3	-2.1	-1.5	-1.9
Heel T-Score	0.3	2.2	5.2	0.2	0.2	2.2	1.0	2.3
Height	0.3	5.2	11.2	-3.3	-2.2	-1.7	-1.0	-2.5
Waist Hip Ratio (WHR)	0.3	1.4	2.9	-0.0	-0.6	1.6	1.7	1.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.3	-0.1	-0.9	-0.6	-0.1	-1.1
Lung FVC	0.3	1.4	2.2	1.4	0.8	-1.5	-1.3	-0.8
Hand grip strength (left)	0.3	0.7	2.1	-0.2	-1.5	0.3	-0.7	0.8
Average weekly spirits intake	0.3	0.4	1.5	-0.2	-1.2	0.5	0.1	0.5
Supplements: Zinc	0.3	0.3	0.6	-0.8	-0.8	-0.5	-0.3	-0.2
Pack years adult smoking proportion	0.3	0.5	1.5	0.5	1.2	-0.6	0.3	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.1	-0.0	0.8	0.9	0.8
Multivitamins +/- minerals	0.3	0.4	1.0	1.0	-0.4	0.4	-0.6	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.7	0.8	0.3	-0.5	0.5
Past tobacco smoking	0.3	0.5	1.8	1.3	-0.2	0.0	-0.2	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.5	1.2	0.9	0.7	0.3	0.9
Financial difficulties in last 2 years	0.3	0.4	1.2	-0.2	-0.7	-0.6	-0.3	-1.1
Arm fat percentage (right)	0.3	1.0	2.3	-0.7	-1.2	-0.8	0.4	-1.5
Impedance of arm (left)	0.3	1.6	3.2	0.6	-0.3	1.1	1.8	1.7
Tense / ‘highly strung’	0.3	0.5	1.0	-0.7	0.2	-0.9	-0.5	-1.0
Peak expiratory flow (PEF)	0.3	0.7	1.2	-0.8	-0.9	-1.1	-0.5	-0.8
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.8	0.1	0.2	0.9	0.5	0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	2.6	-0.3	-0.3	-1.6	-1.3	-1.2
Body fat percentage	0.3	1.1	2.0	-1.2	-1.1	-0.8	0.4	-1.4
Commuting to job workplace: Car/motor vehicle	0.3	0.3	1.2	0.1	0.5	-0.1	-1.1	0.2
Mood swings	0.3	0.5	0.8	-0.4	0.8	-0.6	0.7	-0.9
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-0.8	-1.1	0.3	0.3	0.3
Back pain experienced in last month	0.3	0.4	0.9	-0.7	-1.0	-0.5	0.1	-0.6
Ever taken oral contraceptive pill	0.3	0.4	1.3	-1.2	0.1	-0.3	-0.3	-0.5
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.1	1.0	0.3	-0.5	-0.5	0.0
High cholesterol (Self-reported)	0.3	0.6	1.6	1.3	0.2	0.4	0.9	0.2
Risk taking	0.3	0.4	1.3	-0.5	1.2	0.6	0.3	0.4
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	-1.0	0.0	0.6	0.3	0.2
Heart disease (siblings)	0.3	0.4	0.7	-0.7	-0.4	-0.8	-0.5	-0.5
Pack years of smoking	0.3	0.4	1.4	0.5	1.2	-0.5	0.3	-0.1
Neuroticism (Nagel 2018)	0.2	0.4	0.9	-0.7	-0.2	-0.6	0.2	-1.0
Worry (Nagel 2018)	0.2	0.5	0.9	-0.5	0.2	-1.0	-0.6	-0.9
Prostate Cancer	0.2	0.3	0.6	-0.1	-0.0	0.5	0.6	0.8
HDL Cholesterol	0.2	0.3	0.5	-0.7	0.5	-0.4	0.3	-0.7
Smoking Status	0.2	0.4	0.8	0.2	-0.3	-0.9	0.3	-0.9
Lung FEV1/FVC ratio	0.2	1.2	2.7	-0.4	-0.2	-1.6	-0.7	-1.6
Neuroticism	0.2	0.5	1.5	-0.3	0.4	-0.9	0.1	-1.2
Vitamin and mineral supplements	0.2	0.2	0.9	-0.5	0.9	0.1	-0.1	-0.2
Current tobacco smoking	0.2	0.3	0.7	0.8	0.1	-0.9	-0.1	-0.1
Medication: Atenolol	0.2	0.2	0.4	-0.4	-0.6	-0.4	0.5	-0.3
Forced vital capacity (FVC)	0.2	0.8	1.7	0.0	-0.7	-1.2	-1.3	-0.7
Qualifications: None of the above	0.2	0.5	1.1	-0.6	0.3	-1.0	-0.4	-0.9
Time employed in main current job	0.2	0.3	1.1	0.0	0.1	-0.4	-1.0	-0.4
Lung cancer (father)	0.2	0.3	0.8	-0.9	0.1	-0.4	0.1	-0.7
Length of working week for main job	0.2	0.2	0.6	-0.8	0.4	0.2	-0.2	0.2
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.5	-0.8	-0.2	0.0	-0.2
Medication: Amlodipine	0.2	0.3	0.9	-0.1	-0.5	-0.2	-1.0	0.3
Angina (self-reported)	0.2	0.3	0.5	0.6	0.6	0.4	0.7	0.5
Medication: Allopurinol	0.2	0.2	0.8	0.1	-0.1	0.1	-0.9	0.5
Chest pain or discomfort	0.2	0.3	0.8	-0.9	-0.1	0.1	0.6	-0.5
Had major operations	0.2	0.2	0.5	0.3	-0.1	0.6	-0.2	0.7
Illnesses of father: Heart disease	0.2	0.3	0.6	0.1	-0.7	-0.3	-0.8	0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.6	0.1	-0.6	-0.7	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	0.9	0.3	0.2	-0.1	0.2
Friendships satisfaction	0.2	0.3	0.6	-0.3	-0.7	0.2	0.8	0.3
Smoking status: Current	0.2	0.3	0.9	0.9	0.3	-0.8	-0.1	-0.2
Miserableness	0.2	0.3	1.1	0.3	1.0	0.2	0.7	-0.1
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.0	0.4	-0.7	-0.2	-0.8
Bipolar Disorder (2018)	0.1	0.1	0.3	-0.5	-0.3	-0.2	-0.2	0.4
Crohns Disease (2017)	0.1	0.2	0.4	-0.1	-0.6	0.3	0.6	-0.3
Age at First Birth	0.1	0.2	0.5	-0.1	-0.7	-0.2	0.3	-0.6
Bipolar Disorder (2011)	0.1	0.1	0.3	0.6	0.4	-0.2	-0.3	0.1
Blood Eosinophil Count	0.1	0.9	3.2	-1.1	1.8	-0.0	0.2	0.1
Hair Pigment	0.1	1.7	5.2	0.5	-0.3	1.5	2.3	0.9
Angina	0.1	0.1	0.3	0.4	0.4	0.3	0.5	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.7	0.5	0.1	0.5	0.8	0.5
Heart attack	0.1	0.1	0.2	-0.5	-0.1	0.1	0.4	0.1
Medication: Ramipril	0.1	0.1	0.2	0.4	-0.2	-0.1	0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.5	-0.5	-0.0	-0.1	-0.4
Leg fat percentage (right)	0.1	0.4	1.3	-0.4	-0.2	-0.7	0.1	-1.2
Overall health rating	0.1	0.3	0.6	-0.1	-0.5	-0.5	-0.8	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	-0.1	-0.5	-0.3	-0.5	-0.2
Mineral and other dietary supplements	0.1	0.1	0.3	-0.3	0.6	-0.1	0.3	-0.2
Medication: Blood pressure	0.1	0.1	0.4	0.6	-0.6	0.0	0.2	-0.0
Ever smoked	0.1	0.3	0.9	-0.9	0.2	0.1	0.4	-0.4
Leg fat percentage (left)	0.1	0.3	0.7	-0.5	-0.2	-0.4	0.4	-0.9
Average weekly beer plus cider intake	0.1	0.1	0.2	0.4	0.3	0.2	0.1	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	-0.2	0.2	0.3	0.2
Tanning	0.0	0.5	1.5	-0.7	1.2	0.1	-0.7	-0.4
Hair/balding pattern: Pattern 3	0.0	0.0	0.1	0.1	-0.1	0.1	0.2	0.2
Mother’s age at death	0.0	0.0	0.1	0.1	0.3	-0.2	-0.1	-0.2

Hub : Genes

RALBP1

Models

Trait associations