Hub : Genes

RANBP9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1340	0.0450	4.2e-04	0.144	NA	0.106	NA	0.126	2.4e-08	NA	1.9e-06	NA	1.9e-07
2	GTEx	Artery Tibial	0.1229	0.0426	5.1e-04	0.044	NA	0.047	NA	0.028	2.0e-04	NA	1.5e-04	NA	2.6e-03
3	GTEx	Brain Nucleus accumbens basal ganglia	0.4330	0.1460	7.4e-03	-0.011	NA	-0.010	NA	0.024	9.0e-01	NA	7.8e-01	NA	7.4e-02
4	ROSMAP	Brain Pre-frontal Cortex	0.2416	0.0441	1.5e-13	0.160	0.125	0.159	0.151	0.169	4.9e-20	9.2e-16	5.8e-20	5.7e-19	3.7e-21
5	TCGA	Breast Invasive Carcinoma	0.0304	0.0127	6.8e-05	0.005	0.028	0.018	NA	0.017	3.4e-02	1.7e-06	8.6e-05	NA	1.8e-04
6	TCGA	Soft Tissue Sarcoma	0.1180	0.0680	5.3e-03	0.005	0.016	0.046	NA	0.028	1.6e-01	3.5e-02	9.9e-04	NA	8.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	2.0	3.1	8.0	0.8	0.8	-2.3	-2.8	-1.2	-1.6
Bipolar Disorder or Schizophrenia	2.4	6.0	11.3	2.3	2.9	-2.7	-3.4	-0.9	-1.6
Depressed Affect (Nagel 2018)	0.7	1.4	5.5	-1.0	-1.0	0.4	2.3	0.1	1.1
Depression (Nagel 2018)	0.9	1.3	4.8	-0.8	0.1	-0.0	2.2	-0.6	1.5
Intelligence (Savage-Jansen 2018)	0.5	1.4	4.9	-0.8	0.7	2.2	0.7	1.2	-0.6
Neuroticism (Nagel 2018)	1.0	2.4	6.2	-1.8	-1.2	1.5	2.5	0.6	0.9
Schizophrenia (2018)	1.8	3.7	9.4	2.3	3.1	-1.6	-2.0	-0.3	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.3	0.8	0.9	0.3	-0.9	0.3	0.6	-0.0
Worry (Nagel 2018)	0.9	1.9	5.8	-0.1	0.4	1.4	2.4	0.8	1.6
Alzheimer’s Disease (in mother)	1.3	1.5	7.8	0.6	0.2	-2.8	-0.8	-0.6	0.0
Alzheimer’s Disease (in father)	0.3	0.3	1.2	0.1	0.1	-0.1	-1.1	-0.3	-0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	2.8	0.0	-0.1	-1.7	-0.8	-0.7	-0.3
Crohns Disease (2017)	0.4	1.0	2.5	0.5	-0.4	0.8	-1.6	1.1	-1.1
Irritable Bowel Disease (IBD)	0.2	0.4	1.7	0.8	-0.2	0.1	-1.3	0.2	-0.0
Ulcerative Colitis (UC)	0.4	0.8	1.7	1.3	0.6	-0.7	-0.6	-0.6	1.2
Major Depression (MDD)	3.6	4.4	12.8	0.4	0.9	1.0	3.1	-1.3	3.6
Reaction Time	1.5	2.9	5.0	-1.4	-1.1	0.9	2.2	-1.9	2.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.2	-1.5	-0.2	2.0	0.6	0.3	-1.2
Breast Cancer	8.7	21.0	40.4	-6.4	-5.7	4.6	3.0	-4.6	1.2
Ovarian Cancer	3.2	4.2	7.2	-2.5	-2.7	2.3	1.8	-1.8	-0.1
Prostate Cancer	1.5	2.1	6.3	1.1	0.5	-1.0	2.5	0.9	1.8
Age at First Birth	0.4	0.6	1.9	0.8	0.7	0.6	-0.0	1.4	-0.6
Bipolar Disorder (2011)	0.5	0.5	2.2	0.7	-0.0	-0.6	-1.5	0.0	0.0
Body Mass Index (BMI) (2010)	2.6	3.6	7.0	-0.9	-1.0	2.6	2.6	-0.5	2.5
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.1	-0.3	0.5	0.1	0.3	0.0
Crohns Disease (2012)	0.7	1.1	3.2	0.0	-0.8	1.1	-0.3	1.8	-1.3
Mean Putamen Volume	1.3	1.5	5.9	0.2	1.2	2.4	0.1	0.1	-1.2
Fasting Glucose	0.6	0.7	1.3	1.1	0.5	1.1	-0.8	-0.3	0.7
HbA1C	0.6	0.7	1.9	-1.1	-1.4	-0.6	0.4	-0.4	0.3
HDL Cholesterol	1.5	2.5	9.3	-0.3	-0.5	0.8	-2.2	-0.2	-3.0
LDL Cholesterol	0.5	0.8	1.9	-1.0	-0.8	1.4	1.0	0.0	0.3
Lupus	1.4	2.1	5.7	1.7	2.4	-0.7	0.6	1.3	1.1
Neuroticism (2016)	0.4	0.6	1.4	-0.6	-1.2	-0.7	-0.3	0.6	-0.9
Primary Biliary Cirrhosis	0.8	1.1	3.8	0.9	0.8	2.0	0.1	0.9	0.7
Rheumatoid Arthritis	0.2	0.3	1.5	0.0	-0.1	0.1	0.4	1.2	0.2
Schizophrenia (2014)	1.1	2.4	4.8	1.3	1.6	-1.5	-2.2	-0.7	-1.7
Triglycerides	0.5	0.8	1.4	-1.1	-1.2	0.4	0.5	-0.8	1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.8	-0.4	0.4	0.2	-0.5	-0.4	-0.9
Ulcerative Colitis	0.1	0.1	0.3	0.4	-0.4	0.4	-0.6	0.2	-0.3
Blood Eosinophil Count	0.5	3.8	6.7	-2.6	-1.8	2.2	1.4	-2.2	-1.2
Blood Platelet Count	0.4	4.3	8.0	2.1	1.6	-2.8	-1.0	-2.7	1.6
Blood Red Count	0.7	7.0	21.9	-4.7	-2.9	1.5	-0.5	-2.4	-1.9
Blood White Count	0.1	0.4	0.7	-0.5	-0.4	0.4	0.7	-0.9	0.7
Heel T-Score	0.2	1.5	4.0	0.0	0.6	-1.8	-1.0	-2.0	-0.5
BMI	1.0	5.6	11.0	-2.9	-2.3	3.3	0.6	-2.1	-2.0
Height	0.3	5.0	11.9	2.7	2.7	1.9	0.3	3.5	-0.2
Waist Hip Ratio (WHR)	0.1	0.6	1.2	-0.5	-0.4	0.7	0.6	-1.1	1.1
Systolic Blood Pressure	0.2	0.8	2.0	0.5	0.1	-1.4	-0.6	0.1	-1.4
Smoking Status	0.8	2.0	7.8	0.7	1.1	1.0	1.3	2.8	0.3
Allergy or Eczema	0.3	0.7	3.6	-0.3	-0.4	-1.9	0.0	-0.1	0.4
Cardiovascular Disease	0.3	1.1	4.0	1.1	2.0	-0.9	0.2	0.8	-0.2
Hypothyroidism (self reported)	0.3	0.7	1.8	-0.5	0.2	1.4	1.3	-0.1	-0.6
Respiratory disease	0.9	2.0	4.6	-0.8	-0.3	-1.3	2.1	0.6	2.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	0.4	0.8	0.4	-0.5	-0.2	-0.9
Lung FEV1/FVC ratio	0.2	1.2	4.0	-1.3	-0.1	2.0	-0.4	-1.1	0.0
Lung FVC	0.2	0.9	2.2	-0.7	-1.5	1.3	-0.4	-0.2	-0.9
Neuroticism	1.6	4.0	13.5	-1.4	-1.2	1.2	3.7	0.5	2.3
Chronotype (morning person)	2.5	5.7	15.6	0.3	1.1	-2.1	3.5	-0.2	3.9
Hair Pigment	0.1	1.7	4.1	-1.7	-1.3	2.0	0.4	-0.5	-1.2
Tanning	0.2	2.3	5.7	2.4	1.3	-1.0	0.7	2.1	0.8
Hand grip strength (left)	0.7	1.8	4.5	1.2	2.1	0.0	-0.3	1.9	-1.1
Number of treatments/medications taken	0.2	0.3	0.7	0.6	0.9	-0.8	0.5	0.1	0.3
Average weekly spirits intake	1.6	2.0	6.7	-1.1	-1.0	-0.3	-1.6	-2.6	-0.5
Sensitivity / hurt feelings	0.9	1.6	4.8	-1.8	-2.2	0.7	-0.5	-0.9	-0.4
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.8	0.3	0.6	-0.9	1.7	0.3	1.6
Hearing difficulty/problems: Yes	0.3	0.4	1.9	0.4	-0.1	-1.4	-0.7	0.0	0.1
Relative age of first facial hair	0.3	0.7	1.4	-1.1	-0.2	-0.5	0.7	0.9	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.1	-1.0	-0.0	0.9	-0.5	0.2	-1.0
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.3	-1.5	-1.5	0.4	-0.4	-0.2	-0.3
Ever had hysterectomy (womb removed)	1.2	1.3	3.0	-1.0	-0.5	0.5	1.7	-1.1	1.5
Systolic blood pressure, automated reading	0.5	1.4	4.6	-0.7	-1.3	0.6	-0.9	-0.6	-2.1
Eye problems/disorders: Diabetes related eye disease	2.7	3.0	4.8	-2.0	-2.2	0.1	-1.6	-1.4	-2.1
Angina	0.6	0.8	2.3	1.1	1.5	-0.6	-0.0	0.9	0.6
Medication for hormone replacement therapy	1.2	1.4	3.8	0.5	0.5	0.9	1.5	1.0	1.9
Vitamin and mineral supplements	1.9	2.5	5.6	-0.9	-0.8	1.6	-2.4	-1.2	-2.0
Supplements: Zinc	4.0	4.4	10.1	0.6	0.2	-2.1	3.2	2.5	2.2
Medication: Co-codamol	0.8	0.9	1.8	-0.4	-0.8	-0.7	-1.4	-1.1	-1.1
Medication: Metformin	0.9	1.3	2.0	1.1	1.3	1.4	-1.2	-0.1	-1.1
Diabetes (father)	0.7	0.9	1.9	-0.9	-1.1	-0.4	-1.4	-0.6	-0.9
Diabetes (mother)	0.6	0.8	2.1	0.9	0.5	0.9	0.8	1.4	0.3
Severe depression (siblings)	0.2	0.2	1.0	-0.3	-0.1	-0.3	0.5	-1.0	0.1
Pack years adult smoking proportion	2.5	3.8	13.4	0.6	1.2	-1.0	2.5	0.6	3.7
Impedance of leg (right)	0.9	4.3	11.6	2.4	2.4	-3.4	-1.3	0.9	-0.2
Leg fat-free mass (left)	0.4	1.9	9.0	-0.7	0.2	3.0	0.8	0.9	-0.4
Trunk fat percentage	0.4	1.6	2.7	-1.6	-1.0	1.5	-0.1	-1.3	-1.3
Hand grip strength (right)	0.9	2.5	6.6	1.1	2.6	-0.5	0.4	2.6	0.0
Townsend deprivation index at recruitment	1.1	1.5	4.4	0.8	1.1	-1.1	1.3	-0.4	2.1
Current tobacco smoking	0.5	0.8	1.8	0.2	0.8	0.3	1.2	0.6	1.3
Average weekly fortified wine intake	0.3	0.4	1.0	-0.7	-0.6	0.1	-0.1	-1.0	-0.6
Maternal smoking around birth	0.5	0.7	1.9	-1.0	-1.0	1.4	0.2	-0.1	-0.7
Fed-up feelings	1.3	2.3	5.2	-1.4	-1.5	1.6	2.3	-0.5	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	1.9	-1.0	-0.6	-0.3	1.4	-0.9	1.4
Relative age voice broke	0.1	0.2	0.5	-0.2	0.0	-0.1	-0.7	0.6	0.2
Taking other prescription medications	0.2	0.3	0.8	0.1	0.9	-0.5	0.6	0.5	-0.1
Age when periods started (menarche)	0.2	0.5	1.7	-0.3	0.1	1.0	-0.3	-0.5	-1.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.8	0.1	0.9	-0.1	1.7	1.0	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.2	1.5	1.2	0.2	0.5	0.3	0.7
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	0.9	0.2	-0.2	-0.5	0.8	0.2
Qualifications: CSEs or equivalent	0.9	1.2	4.1	0.3	-0.5	1.4	-0.8	-0.2	-2.0
Serious illness, injury or assault to yourself	0.2	0.3	1.6	-0.1	0.1	-1.3	-0.1	0.3	0.2
High blood pressure	0.2	0.4	1.3	0.4	1.0	-0.3	0.1	1.1	0.0
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.1	-0.4	-0.5	-1.4	0.6	-0.6	0.7
Multivitamins +/- minerals	1.4	1.8	3.7	0.7	0.4	-1.9	1.8	0.9	1.6
Stomach or abdominal pain in last month	0.3	0.4	0.7	-0.2	-0.8	0.2	-0.6	0.6	-0.8
Supplements: Glucosamine	0.8	1.0	3.9	1.0	1.1	-2.0	0.0	-0.1	-0.0
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	1.2	-0.8	-1.1	1.1	0.4	-1.0	-1.1
Medication: Atenolol	0.4	0.5	2.7	0.0	0.1	1.6	-0.2	-0.2	-0.4
Medication: Levothyroxine sodium	0.4	0.6	2.2	-1.0	-0.2	0.7	0.2	-0.1	-1.5
Sitting height	0.5	3.7	8.6	1.6	2.9	-0.0	-0.3	2.9	-1.5
Chronic bronchitis/emphysema (father)	0.4	0.4	1.3	0.9	0.4	-0.4	0.3	0.3	1.1
High blood pressure (mother)	2.2	3.1	4.9	2.2	1.4	-1.1	-1.8	1.9	-2.0
Body mass index (BMI)	1.0	4.4	9.2	-2.8	-2.4	3.0	1.2	-1.5	-0.5
Impedance of leg (left)	0.5	2.3	5.6	1.8	1.8	-2.4	-1.2	0.5	-0.3
Leg predicted mass (left)	0.3	1.8	8.9	-0.7	0.2	3.0	0.9	0.9	-0.5
Trunk fat mass	0.4	1.7	4.5	-1.7	-0.9	2.1	0.2	-0.7	-1.4
Waist circumference	0.8	2.9	8.8	-2.0	-1.1	3.0	1.9	-0.0	0.2
Number of incorrect matches in round	0.4	0.6	1.5	1.2	0.7	-1.2	-0.1	0.5	-0.0
Past tobacco smoking	0.9	1.7	4.2	0.5	0.5	-2.0	-1.1	-2.0	0.4
Alcohol usually taken with meals	1.2	1.9	3.9	1.7	1.7	-0.9	-2.0	0.2	-0.8
Nervous feelings	0.5	1.0	2.0	-0.4	-0.1	-0.4	1.4	1.4	1.3
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	6.2	-0.0	-0.1	0.2	2.5	1.7	1.8
Hearing difficulty/problems with background noise	0.3	0.5	2.1	0.1	0.1	-1.4	0.7	0.3	0.3
Hair/balding pattern: Pattern 2	1.1	1.4	4.2	-1.5	-1.1	2.0	0.9	-0.2	0.4
Had menopause	1.3	1.6	4.3	-1.2	-1.2	-0.8	-1.1	-2.1	-0.9
Had other major operations	0.9	1.1	4.0	2.0	1.2	-0.2	-0.3	1.0	0.4
Forced vital capacity (FVC)	0.2	0.7	1.7	0.6	0.6	0.9	-0.8	0.5	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.7	0.5	0.8	-0.1	-0.1	-0.4
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	3.1	-0.1	0.8	0.2	1.2	-1.6	1.8
Qualifications: None of the above	1.3	2.8	8.3	-2.2	-2.9	0.9	0.2	-1.4	0.6
Financial difficulties in last 2 years	1.8	2.4	8.5	1.3	1.5	-0.1	2.9	0.9	1.3
Mouth/teeth dental problems	0.4	0.5	1.9	1.0	1.4	-0.3	-0.5	0.1	-0.1
Heart attack	1.7	2.2	5.8	-1.1	-1.0	1.5	2.4	0.7	1.6
Allergy	0.5	1.1	2.1	0.8	1.2	1.4	-1.3	0.1	-1.1
Pain all over the body in last month	2.4	2.6	6.3	0.4	1.5	0.0	2.5	0.5	2.5
Diabetes (self-reported)	0.7	1.0	3.2	0.0	0.5	-0.1	-1.6	-0.6	-1.8
Hayfever/allergic rhinitis (self-reported)	0.5	0.7	2.1	-0.6	-0.3	1.1	0.3	-1.5	0.4
Medication: Ramipril	0.8	1.1	2.7	-1.6	-1.3	1.0	0.8	0.1	0.6
Medication: Simvastatin	0.2	0.3	1.4	-0.1	1.2	0.3	0.4	0.2	0.1
Fluid intelligence score	1.4	2.9	6.2	-1.8	-0.3	2.5	2.4	1.2	0.7
Illnesses of siblings	1.0	1.4	3.6	0.1	0.8	0.0	1.9	1.0	1.8
Neuroticism score	1.2	2.5	6.4	-1.5	-1.6	1.2	2.5	-0.0	1.5
Weight	0.5	2.3	8.5	-1.7	-0.7	2.9	1.0	0.1	-0.8
Impedance of arm (right)	1.0	4.8	10.1	2.7	3.2	-2.9	-1.8	0.3	-0.1
Arm fat percentage (right)	0.5	1.8	4.7	-1.6	-1.1	2.2	0.3	-1.2	-0.9
Trunk fat-free mass	0.3	1.7	6.5	-0.4	0.2	2.5	0.7	1.8	-0.3
Hip circumference	0.5	2.2	8.3	-1.5	-0.6	2.9	1.3	0.4	-0.6
Time employed in main current job	1.3	1.5	3.6	-0.4	-0.3	-0.9	-1.8	-1.9	-0.9
Alcohol intake versus 10 years previously	0.4	0.6	1.5	0.3	0.7	0.3	1.2	0.9	0.6
Father’s age at death	0.3	0.4	1.8	-0.3	0.2	-0.5	-1.3	-0.6	0.1
Worrier / anxious feelings	0.4	0.7	3.0	-0.1	-0.1	0.2	1.7	-0.0	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	10.8	1.0	1.1	-3.3	-0.6	-0.8	-0.4
Falls in the last year	0.4	0.6	1.8	-0.6	-0.7	-1.4	-0.4	-0.7	-0.2
Hair/balding pattern: Pattern 3	0.3	0.5	1.5	0.6	0.4	-1.2	0.4	-0.3	0.7
Number of live births	0.2	0.3	1.5	-0.1	-0.3	-1.2	-0.0	-0.3	-0.3
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	2.2	0.1	0.4	1.5	-0.6	0.1	-0.8
Pulse rate	1.0	1.7	3.8	-1.7	-1.3	1.0	1.9	-0.7	0.7
Happiness	0.6	0.7	1.8	-0.2	0.2	-0.2	1.4	0.7	1.3
Noisy workplace	0.7	0.8	2.1	1.1	0.6	-1.0	-1.4	-0.7	0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	4.0	0.4	2.0	-0.7	-1.3	1.3	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	5.5	0.1	0.6	2.4	-0.8	0.8	-0.5
Mouth/teeth dental problems: Dentures	1.3	2.3	3.9	-2.0	-2.0	1.9	1.4	-0.4	0.2
Asthma	1.0	2.0	5.2	-1.0	-0.8	-0.7	2.2	0.3	2.3
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.1	1.2	0.8	-1.8	0.2	0.1	-1.0
Medication: Cholesterol lowering	1.0	1.5	2.8	1.0	1.7	0.7	0.7	1.5	1.5
Depression (self-reported)	1.1	1.4	3.8	-1.0	-0.5	-0.7	2.0	-1.1	1.2
Medication: Lansoprazole	0.6	0.7	2.0	-0.3	-0.2	0.2	-0.8	1.1	-1.4
Prospective memory result	1.5	1.8	6.0	2.5	1.3	-1.2	-1.3	0.2	-0.2
Lung cancer (father)	1.3	1.5	3.0	0.5	-0.1	1.7	1.7	0.7	1.6
Illnesses of mother	2.9	3.6	5.4	-2.3	-0.9	2.1	1.9	-1.6	2.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.6	1.1	1.4	1.6	-0.5	1.3	-1.0
Pulse wave Arterial Stiffness index	1.0	1.2	3.7	-1.2	-0.4	1.0	1.9	0.1	0.8
Impedance of arm (left)	1.2	5.7	11.6	3.0	3.4	-3.1	-1.6	0.8	-0.4
Arm fat mass (right)	0.6	2.3	7.8	-1.7	-1.1	2.8	0.4	-0.9	-0.9
Trunk predicted mass	0.3	1.7	6.5	-0.4	0.2	2.5	0.8	1.7	-0.2
Standing height	0.4	4.2	10.2	1.9	3.2	0.2	-0.7	3.1	-1.2
Length of working week for main job	0.6	0.7	1.9	-1.4	-0.7	0.7	0.7	-0.9	-0.4
Exposure to tobacco smoke at home	1.2	1.3	2.1	-1.4	-1.0	-0.8	1.1	-1.1	1.5
Breastfed as a baby	0.8	0.9	2.9	0.7	0.3	-0.9	-1.7	0.6	-1.0
Tense / ‘highly strung’	0.4	0.6	1.7	0.8	0.5	-1.3	0.7	0.1	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	4.4	-0.4	0.9	-0.1	2.1	0.5	1.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.2	0.1	-0.6	0.1	-0.6	1.0	-1.1
Birth weight of first child	0.2	0.3	0.6	-0.8	0.1	-0.5	0.4	0.6	-0.7
Peak expiratory flow (PEF)	0.3	0.8	3.9	-0.5	-0.1	2.0	-0.1	0.7	-0.4
Pulse wave reflection index	0.3	0.4	0.8	-0.6	-0.4	0.9	0.4	0.7	-0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.0	0.3	-0.7	-0.6	-1.0	-0.6	-0.0
Loud music exposure frequency	0.2	0.2	0.6	0.1	-0.2	0.0	-0.0	0.8	0.7
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	1.0	1.3	-1.2	-0.7	0.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.9	-0.1	-0.4	-0.6	-0.9	-0.1	-0.2
Blood clot in the leg (DVT)	0.6	0.7	3.5	0.7	0.6	-1.9	0.4	0.1	-0.1
Medication: Paracetamol	0.4	0.7	1.4	1.2	0.6	-0.9	-1.1	-0.6	-0.6
Headache pain in last month	2.7	4.7	11.6	2.8	2.3	-3.4	-1.0	1.3	-0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	3.6	-1.1	-1.9	-0.7	-1.0	-1.4	-1.2
Glaucoma (self-reported)	1.7	2.0	4.8	2.2	1.8	-1.0	-1.3	1.0	-0.6
Gout (self-reported)	0.3	0.4	1.4	0.5	0.1	0.2	1.2	0.5	0.8
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.9	-0.3	0.7	0.8	-0.4	-0.6
Medication: Amlodipine	0.5	0.7	1.7	-0.8	-1.1	1.3	0.4	-0.4	0.1
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	0.9	1.2	-1.0	-0.3	-0.1	1.1
Birth weight	0.4	0.8	1.2	0.8	1.0	-0.2	-1.1	1.0	-1.0
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	-0.1	-0.8	-0.5	-0.9	-0.9	-0.7
High blood pressure (siblings)	1.7	2.4	8.4	1.5	0.1	0.0	-2.9	0.7	-1.8
Forced vital capacity (FVC), Best measure	0.3	1.2	1.7	1.2	1.0	1.3	-0.4	1.2	-1.2
Body fat percentage	0.4	1.7	3.7	-1.6	-1.0	1.9	0.2	-1.3	-1.1
Leg fat percentage (right)	0.4	1.3	2.3	-1.5	-0.8	1.5	1.4	-0.9	0.0
Arm fat-free mass (right)	0.4	2.0	7.7	-1.2	-0.9	2.8	0.6	0.8	-0.9
Exposure to tobacco smoke outside home	0.6	0.8	3.0	-0.2	-0.5	0.8	0.7	-0.6	1.7
Comparative body size at age 10	1.1	3.1	7.0	-1.9	-2.6	2.0	0.9	1.1	-1.3
Number of full brothers	2.9	3.7	6.1	1.5	1.5	-0.2	2.4	2.3	2.5
Worry too long after embarrassment	1.4	2.4	5.5	-2.3	-1.7	1.1	1.5	-0.7	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	2.0	-0.4	0.1	-0.8	0.3	-1.2	1.4
Wheeze or whistling in the chest in last year	0.1	0.1	0.3	0.4	0.1	-0.6	0.2	0.2	0.2
Number of children fathered	2.3	2.5	7.2	0.7	0.6	-0.5	-2.7	-1.2	-2.3
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.1	-0.2	-0.5	0.7	-1.2	-1.8	-1.1
Age at first live birth	0.9	1.6	4.2	1.1	2.0	0.2	-0.1	1.9	-0.9
Pulse wave peak to peak time	1.2	1.4	3.9	1.4	0.6	-1.0	-2.0	0.2	-1.0
Health satisfaction	0.3	0.4	1.5	-0.5	-0.3	0.3	0.6	-0.2	1.2
Shortness of breath walking on level ground	1.1	1.3	4.8	-0.7	-0.5	1.1	0.8	-0.9	2.2
Qualifications: College or University degree	0.2	0.7	1.5	0.1	1.2	-1.1	-0.6	-1.0	-0.2
Eye problems/disorders: None of the above	0.5	0.5	2.3	-0.4	-0.8	-0.3	-0.3	-1.5	-0.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	0.4	0.0	-0.5	-0.2	0.7	0.5
Emphysema/chronic bronchitis	2.2	2.5	4.9	-2.0	-2.2	1.0	1.9	-0.4	1.2
Medication for pain relief, constipation, heartburn	0.6	1.0	2.4	-1.6	-1.0	1.0	-0.1	1.1	-0.3
Neck or shoulder pain in last month	0.3	0.4	0.9	-0.8	-0.4	-0.9	0.1	-0.5	-0.6
Medication: Blood pressure	0.7	1.3	2.0	0.8	1.1	1.2	1.4	1.4	0.7
Angina (self-reported)	0.9	1.2	3.5	1.3	1.9	-0.7	0.2	1.0	0.9
Migraine (self-reported)	0.4	0.5	1.7	0.8	1.3	-0.2	0.4	0.4	0.5
Medication: Ibuprofen	0.5	0.6	1.4	1.1	0.6	-1.0	0.1	0.2	-1.2
Medication: Allopurinol	0.5	0.7	1.5	1.2	0.4	-0.4	0.4	1.1	-1.0
Medication: Omeprazole	1.5	1.7	4.1	1.5	1.3	-2.0	0.9	-0.4	1.1
Medication: Seretide 50 evohaler	0.7	0.8	1.2	-0.5	-1.1	-1.0	-0.3	0.9	-1.0
Mean time to correctly identify matches	1.4	2.6	3.7	-1.8	-1.9	1.0	1.6	-1.7	1.5
Heart disease (mother)	0.6	0.7	1.8	0.5	1.2	-0.9	-0.2	0.2	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.2	-0.2	-1.1	-0.5	0.6	2.3	-0.8
Whole body fat mass	0.5	2.0	6.6	-1.6	-0.9	2.6	0.3	-0.7	-1.1
Leg fat mass (right)	0.4	1.7	6.2	-1.4	-0.5	2.5	1.1	-0.4	-0.5
Arm predicted mass (right)	0.5	2.5	8.8	-1.6	-1.1	3.0	0.8	0.7	-1.0
Pulse rate, automated reading	0.4	1.3	3.2	-1.0	-0.5	0.8	1.8	-1.2	1.1
Alcohol intake frequency.	0.5	1.1	3.2	-1.4	-1.0	-0.7	1.8	-0.3	-0.3
Comparative height size at age 10	0.3	1.4	3.6	0.9	1.6	1.1	0.6	1.9	0.1
Number of full sisters	0.2	0.3	1.0	-1.0	-0.2	-0.1	0.1	-0.6	0.7
Suffer from ‘nerves’	0.4	0.6	1.2	-0.0	-0.1	0.8	0.9	1.0	1.1
Overall health rating	0.3	0.7	1.7	-0.5	0.1	-0.3	1.1	-0.7	1.3
Chest pain or discomfort	0.8	1.1	3.5	0.1	0.7	0.4	1.5	0.1	1.9
Had major operations	0.8	1.0	2.4	-1.5	-1.2	0.7	0.1	-1.2	0.5
Age at last live birth	0.5	0.7	1.8	0.7	1.4	-0.1	0.1	1.2	-0.4
Family relationship satisfaction	0.5	0.6	1.4	-0.5	-0.5	0.6	1.2	1.1	0.1
Leg pain on walking	0.2	0.2	0.8	-0.4	-0.0	-0.6	0.4	0.1	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.5	-0.2	-0.1	1.0	0.1	1.2	-0.3
Commuting to job workplace: Car/motor vehicle	1.4	1.6	5.2	0.1	-0.4	0.6	-1.7	-1.0	-2.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.5	-0.3	-0.5	0.7	-0.3	-0.3	-0.6
Medication: Aspirin	0.2	0.3	0.9	-0.5	-0.2	0.4	0.5	-1.0	-0.1
Supplements: Vitamin C	0.5	0.6	2.4	-0.2	-0.5	0.7	1.5	0.7	0.4
Knee pain experienced in last month	0.5	0.8	2.2	1.4	1.5	-0.5	-0.2	0.3	-0.4
Hypertension (Self-reported)	0.2	0.5	1.2	0.4	1.1	-0.7	0.2	1.0	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	6.7	1.6	1.9	-2.6	0.8	0.8	1.0
Illnesses of father: Heart disease	1.7	2.3	5.2	1.0	1.1	-1.6	-1.7	1.0	-2.3
Illnesses of siblings: Diabetes	0.8	0.9	1.3	-0.7	-1.1	0.9	-1.2	-1.0	-0.9
Smoking status: Previous	0.8	1.2	4.0	-0.3	-0.3	1.4	0.8	2.0	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	5.3	1.7	2.3	-1.3	-1.1	1.1	-0.6
Whole body fat-free mass	0.3	1.9	8.5	-0.7	-0.0	2.9	0.8	1.3	-0.5
Leg fat-free mass (right)	0.4	2.3	11.6	-0.9	-0.0	3.4	0.9	0.8	-0.4
Arm fat percentage (left)	0.5	1.9	5.1	-1.7	-1.1	2.2	0.5	-1.1	-0.9
Average weekly red wine intake	0.7	1.0	3.3	-0.2	-0.1	-1.8	-1.1	0.8	-0.9
Handedness (chirality/laterality): Left-handed	2.0	2.4	7.0	-1.8	-2.7	1.1	0.9	-0.6	-1.3
Mood swings	0.3	0.6	1.9	-0.5	-1.4	0.3	0.5	0.6	-0.7
Loneliness, isolation	0.6	0.8	2.5	-1.2	-1.6	0.1	0.1	-0.5	0.8
Long-standing illness, disability or infirmity	0.5	0.8	2.0	-1.1	0.4	-0.2	1.4	0.4	1.1
Ever had bowel cancer screening	0.1	0.2	0.8	-0.3	0.1	0.2	-0.9	-0.1	-0.3
Diabetes diagnosed by doctor	0.6	1.0	2.6	-0.0	0.5	0.2	-1.6	-0.8	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	-0.2	-0.3	1.1	0.5	0.7	0.2
Friendships satisfaction	1.3	1.6	6.1	-0.3	-0.2	0.1	1.6	2.5	0.8
Qualifications: nursing, teaching	2.0	3.2	10.8	0.3	0.3	-0.6	-2.7	-0.5	-3.3
Commuting to job workplace: Walk	0.3	0.3	0.9	0.1	0.7	-0.2	0.6	-0.3	0.9
Eye problems/disorders: Cataract	0.5	0.6	1.6	0.3	1.0	0.2	0.8	1.3	0.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.3	1.5	1.3	-1.3	-0.5	0.8	-0.6
Medication for cholesterol	0.2	0.4	1.0	0.4	-0.2	-0.6	-1.0	-0.7	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.4	1.1	1.2	-0.6	-0.5	0.7	0.7
Back pain experienced in last month	0.8	1.2	3.4	0.6	0.3	-1.8	-0.7	-0.4	-1.6
Mineral and other dietary supplements	0.7	0.9	3.1	-1.2	-0.2	1.8	-0.5	0.6	-0.2
Breast cancer (self-reported)	0.6	0.8	1.4	0.9	0.4	-0.8	-0.9	1.2	-1.0
Asthma (self-reported)	1.3	2.7	7.5	-0.9	-0.8	-1.1	2.4	0.3	2.7
Osteoporosis (self-reported)	0.3	0.4	1.6	-0.4	-0.3	-0.4	1.2	0.6	0.2
Osteoarthritis (self-reported)	0.6	0.7	1.3	-0.9	-0.7	0.6	1.1	-1.1	-0.2
Medication: Aspirin	0.5	0.7	1.6	-1.0	-0.5	0.7	0.7	-1.2	-0.2
Medication: Gliclazide	1.4	1.6	5.5	-0.2	0.1	1.6	-1.3	0.1	-2.3
Illnesses of father: None of the above (group 1)	2.6	3.2	10.0	-0.5	-0.0	1.2	2.7	-0.6	3.2
Smoking status: Current	0.7	1.1	2.4	0.5	1.2	0.2	1.4	0.7	1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	1.5	-0.3	-0.5	1.2	-0.5	-0.6	-0.3
Whole body water mass	0.3	2.0	8.8	-0.8	-0.1	3.0	0.7	1.2	-0.6
Leg predicted mass (right)	0.4	2.3	11.4	-0.8	-0.0	3.4	0.8	0.8	-0.4
Arm fat mass (left)	0.6	2.4	7.3	-1.9	-1.2	2.7	0.3	-0.8	-1.1
Number of self-reported non-cancer illnesses	0.2	0.4	0.9	0.0	1.0	-0.9	0.2	0.2	0.5
Average weekly champagne plus white wine intake	2.6	3.5	8.6	2.4	2.9	-2.1	-0.1	1.0	1.3
Miserableness	0.4	0.7	1.8	-0.1	-1.1	-0.4	1.4	0.6	0.8
Guilty feelings	2.3	3.4	7.7	-2.8	-2.2	2.3	1.4	-0.6	-0.7
Wears glasses or contact lenses	2.2	2.6	7.7	-1.9	-1.4	1.3	0.1	-2.8	0.8
Ever taken oral contraceptive pill	3.0	3.3	7.3	2.7	2.2	-1.8	-0.1	2.0	0.7
Hearing aid user	3.4	3.8	10.2	-0.6	-1.8	-0.4	-2.9	-0.8	-3.2
Mother’s age at death	0.2	0.2	0.9	-0.3	-0.4	-0.5	-0.3	-0.9	0.3
Financial situation satisfaction	1.2	1.4	3.2	1.8	1.6	-1.3	0.0	0.9	-0.4
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.8	-1.3	-0.1	1.1	1.9	-1.6	1.4
Commuting to job workplace: Public transport	0.6	0.7	1.3	-0.8	-0.9	0.0	0.8	-0.7	1.1
Eye problems/disorders: Glaucoma	2.4	2.9	7.4	2.7	1.9	-1.0	-1.3	1.8	-0.4
Medication: Blood pressure	0.3	0.6	1.9	0.0	0.5	-0.6	0.8	1.4	-0.6
Pain type(s) experienced in last month: Hip pain	0.6	0.7	3.0	0.3	0.5	0.4	1.7	0.6	0.7
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.9	0.9	0.1	-1.7	0.9	0.2	-0.1
High cholesterol (Self-reported)	0.3	0.5	1.3	-1.1	-0.3	0.7	1.1	0.1	-0.1
Medication: Bendroflumethiazide	0.4	0.6	0.9	-0.6	0.3	0.9	0.8	0.9	0.8
Medication: Paracetamol	0.4	0.7	1.1	1.0	0.5	-0.7	-1.0	-0.4	-1.1
Medication: Lisinopril	0.7	0.9	3.2	0.9	0.6	-1.8	0.8	0.8	0.1
Medication: Atorvastatin	0.3	0.3	0.7	0.3	0.5	0.5	0.5	0.8	0.6
Illnesses of father: High blood pressure	0.7	0.9	2.1	-1.0	-0.8	0.8	-0.4	0.9	-1.4
Alcohol drinker status: Never	1.4	1.7	5.6	-0.6	0.0	-0.4	2.4	1.0	1.7
Ever smoked	0.9	1.6	5.5	-0.3	-0.5	1.8	0.7	2.3	-0.0
Basal metabolic rate	0.4	2.0	9.2	-0.9	-0.1	3.0	0.8	1.1	-0.6
Leg fat percentage (left)	0.6	2.1	4.1	-1.9	-1.3	2.0	1.3	-1.3	-0.1
Arm fat-free mass (left)	0.5	2.3	8.9	-1.6	-1.0	3.0	0.5	0.6	-0.9
Number of operations (self-reported)	0.3	0.5	1.6	0.0	0.5	1.0	-0.2	-1.3	-0.2
Average weekly beer plus cider intake	0.2	0.2	0.7	0.2	-0.6	0.1	0.4	0.1	0.8
Irritability	1.2	2.0	7.6	-1.6	-2.8	1.0	0.6	-0.0	-0.8
Risk taking	0.7	1.0	2.2	-0.6	-0.9	-0.1	1.4	0.9	1.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.0	0.9	0.8	-0.4	0.2	-0.6	1.0
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.4	0.9	-0.8	0.2	0.2	0.6
Age started oral contraceptive pill	0.8	1.0	3.1	-0.5	-0.6	-0.6	-1.1	0.8	-1.8
Diastolic blood pressure, automated reading	0.5	1.4	4.3	2.1	1.7	-0.8	-0.4	0.8	-0.5
Ever depressed for a whole week	2.3	2.8	7.4	-0.8	-0.4	1.3	2.6	-0.2	2.7
Unable to work because of sickness or disability	0.7	0.9	2.4	-0.8	-0.2	0.2	1.5	0.2	1.5
Commuting to job workplace: Cycle	1.3	1.6	4.5	-0.9	-0.3	-0.1	2.1	0.3	2.0
Myopia	0.3	0.4	1.1	-1.1	-0.2	0.2	-0.5	-1.0	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.1	-0.1	-0.7	-0.2	-0.7	-1.1	-0.4
Cholesterol lowering medication	0.4	0.6	1.1	-1.1	-0.5	0.9	0.5	-0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	2.9	1.7	1.3	-1.4	1.1	-0.7	1.7
Pain experienced in last month	1.3	2.2	4.6	-2.1	-1.8	1.9	0.1	-0.8	0.7
Supplements: Calcium	0.3	0.3	1.2	-0.5	-0.3	-1.1	0.7	0.1	0.1
Basal cell carcinoma (self-reported)	0.8	0.9	3.3	-0.0	0.6	-1.8	1.0	-0.9	0.2
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.8	-1.0	-0.9	1.3	2.4	0.7	1.7
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.8	0.1	0.1	-1.7	0.2	-0.1	-0.2
Heart disease (siblings)	0.2	0.3	0.8	0.0	-0.4	-0.6	0.5	-0.3	0.9
Alcohol drinker status: Previous	1.6	1.8	5.9	-2.4	-1.7	0.2	1.1	-0.0	-0.9
Pack years of smoking	2.1	3.1	11.6	0.1	0.6	-0.8	2.5	0.2	3.4
Impedance of whole body	0.8	4.2	10.1	2.4	2.5	-3.2	-1.7	0.6	-0.5
Leg fat mass (left)	0.6	2.2	8.0	-1.7	-0.9	2.8	0.9	-0.7	-0.6
Arm predicted mass (left)	0.4	2.1	8.5	-1.4	-0.9	2.9	0.7	0.6	-0.6