Hub : Genes

RANBP9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1340 0.0450 4.2e-04 0.144 NA 0.106 NA 0.126 2.4e-08 NA 1.9e-06 NA 1.9e-07
2 GTEx Artery Tibial 0.1229 0.0426 5.1e-04 0.044 NA 0.047 NA 0.028 2.0e-04 NA 1.5e-04 NA 2.6e-03
3 GTEx Brain Nucleus accumbens basal ganglia 0.4330 0.1460 7.4e-03 -0.011 NA -0.010 NA 0.024 9.0e-01 NA 7.8e-01 NA 7.4e-02
4 ROSMAP Brain Pre-frontal Cortex 0.2416 0.0441 1.5e-13 0.160 0.125 0.159 0.151 0.169 4.9e-20 9.2e-16 5.8e-20 5.7e-19 3.7e-21
5 TCGA Breast Invasive Carcinoma 0.0304 0.0127 6.8e-05 0.005 0.028 0.018 NA 0.017 3.4e-02 1.7e-06 8.6e-05 NA 1.8e-04
6 TCGA Soft Tissue Sarcoma 0.1180 0.0680 5.3e-03 0.005 0.016 0.046 NA 0.028 1.6e-01 3.5e-02 9.9e-04 NA 8.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 2.0 3.1 8.0 0.8 0.8 -2.3 -2.8 -1.2 -1.6
Bipolar Disorder or Schizophrenia 2.4 6.0 11.3 2.3 2.9 -2.7 -3.4 -0.9 -1.6
Depressed Affect (Nagel 2018) 0.7 1.4 5.5 -1.0 -1.0 0.4 2.3 0.1 1.1
Depression (Nagel 2018) 0.9 1.3 4.8 -0.8 0.1 -0.0 2.2 -0.6 1.5
Intelligence (Savage-Jansen 2018) 0.5 1.4 4.9 -0.8 0.7 2.2 0.7 1.2 -0.6
Neuroticism (Nagel 2018) 1.0 2.4 6.2 -1.8 -1.2 1.5 2.5 0.6 0.9
Schizophrenia (2018) 1.8 3.7 9.4 2.3 3.1 -1.6 -2.0 -0.3 -0.7
Schizophrenia vs Biploar Disorder 0.3 0.3 0.8 0.9 0.3 -0.9 0.3 0.6 -0.0
Worry (Nagel 2018) 0.9 1.9 5.8 -0.1 0.4 1.4 2.4 0.8 1.6
Alzheimer’s Disease (in mother) 1.3 1.5 7.8 0.6 0.2 -2.8 -0.8 -0.6 0.0
Alzheimer’s Disease (in father) 0.3 0.3 1.2 0.1 0.1 -0.1 -1.1 -0.3 -0.8
Alzheimer’s Disease (including proxy) 0.5 0.7 2.8 0.0 -0.1 -1.7 -0.8 -0.7 -0.3
Crohns Disease (2017) 0.4 1.0 2.5 0.5 -0.4 0.8 -1.6 1.1 -1.1
Irritable Bowel Disease (IBD) 0.2 0.4 1.7 0.8 -0.2 0.1 -1.3 0.2 -0.0
Ulcerative Colitis (UC) 0.4 0.8 1.7 1.3 0.6 -0.7 -0.6 -0.6 1.2
Major Depression (MDD) 3.6 4.4 12.8 0.4 0.9 1.0 3.1 -1.3 3.6
Reaction Time 1.5 2.9 5.0 -1.4 -1.1 0.9 2.2 -1.9 2.2
Verbal and Numeric Reasoning (VNR) 0.6 1.4 4.2 -1.5 -0.2 2.0 0.6 0.3 -1.2
Breast Cancer 8.7 21.0 40.4 -6.4 -5.7 4.6 3.0 -4.6 1.2
Ovarian Cancer 3.2 4.2 7.2 -2.5 -2.7 2.3 1.8 -1.8 -0.1
Prostate Cancer 1.5 2.1 6.3 1.1 0.5 -1.0 2.5 0.9 1.8
Age at First Birth 0.4 0.6 1.9 0.8 0.7 0.6 -0.0 1.4 -0.6
Bipolar Disorder (2011) 0.5 0.5 2.2 0.7 -0.0 -0.6 -1.5 0.0 0.0
Body Mass Index (BMI) (2010) 2.6 3.6 7.0 -0.9 -1.0 2.6 2.6 -0.5 2.5
Coronary Artery Disease (CAD) 0.1 0.1 0.3 0.1 -0.3 0.5 0.1 0.3 0.0
Crohns Disease (2012) 0.7 1.1 3.2 0.0 -0.8 1.1 -0.3 1.8 -1.3
Mean Putamen Volume 1.3 1.5 5.9 0.2 1.2 2.4 0.1 0.1 -1.2
Fasting Glucose 0.6 0.7 1.3 1.1 0.5 1.1 -0.8 -0.3 0.7
HbA1C 0.6 0.7 1.9 -1.1 -1.4 -0.6 0.4 -0.4 0.3
HDL Cholesterol 1.5 2.5 9.3 -0.3 -0.5 0.8 -2.2 -0.2 -3.0
LDL Cholesterol 0.5 0.8 1.9 -1.0 -0.8 1.4 1.0 0.0 0.3
Lupus 1.4 2.1 5.7 1.7 2.4 -0.7 0.6 1.3 1.1
Neuroticism (2016) 0.4 0.6 1.4 -0.6 -1.2 -0.7 -0.3 0.6 -0.9
Primary Biliary Cirrhosis 0.8 1.1 3.8 0.9 0.8 2.0 0.1 0.9 0.7
Rheumatoid Arthritis 0.2 0.3 1.5 0.0 -0.1 0.1 0.4 1.2 0.2
Schizophrenia (2014) 1.1 2.4 4.8 1.3 1.6 -1.5 -2.2 -0.7 -1.7
Triglycerides 0.5 0.8 1.4 -1.1 -1.2 0.4 0.5 -0.8 1.1
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.8 -0.4 0.4 0.2 -0.5 -0.4 -0.9
Ulcerative Colitis 0.1 0.1 0.3 0.4 -0.4 0.4 -0.6 0.2 -0.3
Blood Eosinophil Count 0.5 3.8 6.7 -2.6 -1.8 2.2 1.4 -2.2 -1.2
Blood Platelet Count 0.4 4.3 8.0 2.1 1.6 -2.8 -1.0 -2.7 1.6
Blood Red Count 0.7 7.0 21.9 -4.7 -2.9 1.5 -0.5 -2.4 -1.9
Blood White Count 0.1 0.4 0.7 -0.5 -0.4 0.4 0.7 -0.9 0.7
Heel T-Score 0.2 1.5 4.0 0.0 0.6 -1.8 -1.0 -2.0 -0.5
BMI 1.0 5.6 11.0 -2.9 -2.3 3.3 0.6 -2.1 -2.0
Height 0.3 5.0 11.9 2.7 2.7 1.9 0.3 3.5 -0.2
Waist Hip Ratio (WHR) 0.1 0.6 1.2 -0.5 -0.4 0.7 0.6 -1.1 1.1
Systolic Blood Pressure 0.2 0.8 2.0 0.5 0.1 -1.4 -0.6 0.1 -1.4
Smoking Status 0.8 2.0 7.8 0.7 1.1 1.0 1.3 2.8 0.3
Allergy or Eczema 0.3 0.7 3.6 -0.3 -0.4 -1.9 0.0 -0.1 0.4
Cardiovascular Disease 0.3 1.1 4.0 1.1 2.0 -0.9 0.2 0.8 -0.2
Hypothyroidism (self reported) 0.3 0.7 1.8 -0.5 0.2 1.4 1.3 -0.1 -0.6
Respiratory disease 0.9 2.0 4.6 -0.8 -0.3 -1.3 2.1 0.6 2.1
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.9 0.4 0.8 0.4 -0.5 -0.2 -0.9
Lung FEV1/FVC ratio 0.2 1.2 4.0 -1.3 -0.1 2.0 -0.4 -1.1 0.0
Lung FVC 0.2 0.9 2.2 -0.7 -1.5 1.3 -0.4 -0.2 -0.9
Neuroticism 1.6 4.0 13.5 -1.4 -1.2 1.2 3.7 0.5 2.3
Chronotype (morning person) 2.5 5.7 15.6 0.3 1.1 -2.1 3.5 -0.2 3.9
Hair Pigment 0.1 1.7 4.1 -1.7 -1.3 2.0 0.4 -0.5 -1.2
Tanning 0.2 2.3 5.7 2.4 1.3 -1.0 0.7 2.1 0.8
Hand grip strength (left) 0.7 1.8 4.5 1.2 2.1 0.0 -0.3 1.9 -1.1
Number of treatments/medications taken 0.2 0.3 0.7 0.6 0.9 -0.8 0.5 0.1 0.3
Average weekly spirits intake 1.6 2.0 6.7 -1.1 -1.0 -0.3 -1.6 -2.6 -0.5
Sensitivity / hurt feelings 0.9 1.6 4.8 -1.8 -2.2 0.7 -0.5 -0.9 -0.4
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.8 0.3 0.6 -0.9 1.7 0.3 1.6
Hearing difficulty/problems: Yes 0.3 0.4 1.9 0.4 -0.1 -1.4 -0.7 0.0 0.1
Relative age of first facial hair 0.3 0.7 1.4 -1.1 -0.2 -0.5 0.7 0.9 1.2
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.1 -1.0 -0.0 0.9 -0.5 0.2 -1.0
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.3 -1.5 -1.5 0.4 -0.4 -0.2 -0.3
Ever had hysterectomy (womb removed) 1.2 1.3 3.0 -1.0 -0.5 0.5 1.7 -1.1 1.5
Systolic blood pressure, automated reading 0.5 1.4 4.6 -0.7 -1.3 0.6 -0.9 -0.6 -2.1
Eye problems/disorders: Diabetes related eye disease 2.7 3.0 4.8 -2.0 -2.2 0.1 -1.6 -1.4 -2.1
Angina 0.6 0.8 2.3 1.1 1.5 -0.6 -0.0 0.9 0.6
Medication for hormone replacement therapy 1.2 1.4 3.8 0.5 0.5 0.9 1.5 1.0 1.9
Vitamin and mineral supplements 1.9 2.5 5.6 -0.9 -0.8 1.6 -2.4 -1.2 -2.0
Supplements: Zinc 4.0 4.4 10.1 0.6 0.2 -2.1 3.2 2.5 2.2
Medication: Co-codamol 0.8 0.9 1.8 -0.4 -0.8 -0.7 -1.4 -1.1 -1.1
Medication: Metformin 0.9 1.3 2.0 1.1 1.3 1.4 -1.2 -0.1 -1.1
Diabetes (father) 0.7 0.9 1.9 -0.9 -1.1 -0.4 -1.4 -0.6 -0.9
Diabetes (mother) 0.6 0.8 2.1 0.9 0.5 0.9 0.8 1.4 0.3
Severe depression (siblings) 0.2 0.2 1.0 -0.3 -0.1 -0.3 0.5 -1.0 0.1
Pack years adult smoking proportion 2.5 3.8 13.4 0.6 1.2 -1.0 2.5 0.6 3.7
Impedance of leg (right) 0.9 4.3 11.6 2.4 2.4 -3.4 -1.3 0.9 -0.2
Leg fat-free mass (left) 0.4 1.9 9.0 -0.7 0.2 3.0 0.8 0.9 -0.4
Trunk fat percentage 0.4 1.6 2.7 -1.6 -1.0 1.5 -0.1 -1.3 -1.3
Hand grip strength (right) 0.9 2.5 6.6 1.1 2.6 -0.5 0.4 2.6 0.0
Townsend deprivation index at recruitment 1.1 1.5 4.4 0.8 1.1 -1.1 1.3 -0.4 2.1
Current tobacco smoking 0.5 0.8 1.8 0.2 0.8 0.3 1.2 0.6 1.3
Average weekly fortified wine intake 0.3 0.4 1.0 -0.7 -0.6 0.1 -0.1 -1.0 -0.6
Maternal smoking around birth 0.5 0.7 1.9 -1.0 -1.0 1.4 0.2 -0.1 -0.7
Fed-up feelings 1.3 2.3 5.2 -1.4 -1.5 1.6 2.3 -0.5 1.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 1.9 -1.0 -0.6 -0.3 1.4 -0.9 1.4
Relative age voice broke 0.1 0.2 0.5 -0.2 0.0 -0.1 -0.7 0.6 0.2
Taking other prescription medications 0.2 0.3 0.8 0.1 0.9 -0.5 0.6 0.5 -0.1
Age when periods started (menarche) 0.2 0.5 1.7 -0.3 0.1 1.0 -0.3 -0.5 -1.3
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.8 0.1 0.9 -0.1 1.7 1.0 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.2 1.5 1.2 0.2 0.5 0.3 0.7
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.9 0.9 0.2 -0.2 -0.5 0.8 0.2
Qualifications: CSEs or equivalent 0.9 1.2 4.1 0.3 -0.5 1.4 -0.8 -0.2 -2.0
Serious illness, injury or assault to yourself 0.2 0.3 1.6 -0.1 0.1 -1.3 -0.1 0.3 0.2
High blood pressure 0.2 0.4 1.3 0.4 1.0 -0.3 0.1 1.1 0.0
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.1 -0.4 -0.5 -1.4 0.6 -0.6 0.7
Multivitamins +/- minerals 1.4 1.8 3.7 0.7 0.4 -1.9 1.8 0.9 1.6
Stomach or abdominal pain in last month 0.3 0.4 0.7 -0.2 -0.8 0.2 -0.6 0.6 -0.8
Supplements: Glucosamine 0.8 1.0 3.9 1.0 1.1 -2.0 0.0 -0.1 -0.0
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.2 -0.8 -1.1 1.1 0.4 -1.0 -1.1
Medication: Atenolol 0.4 0.5 2.7 0.0 0.1 1.6 -0.2 -0.2 -0.4
Medication: Levothyroxine sodium 0.4 0.6 2.2 -1.0 -0.2 0.7 0.2 -0.1 -1.5
Sitting height 0.5 3.7 8.6 1.6 2.9 -0.0 -0.3 2.9 -1.5
Chronic bronchitis/emphysema (father) 0.4 0.4 1.3 0.9 0.4 -0.4 0.3 0.3 1.1
High blood pressure (mother) 2.2 3.1 4.9 2.2 1.4 -1.1 -1.8 1.9 -2.0
Body mass index (BMI) 1.0 4.4 9.2 -2.8 -2.4 3.0 1.2 -1.5 -0.5
Impedance of leg (left) 0.5 2.3 5.6 1.8 1.8 -2.4 -1.2 0.5 -0.3
Leg predicted mass (left) 0.3 1.8 8.9 -0.7 0.2 3.0 0.9 0.9 -0.5
Trunk fat mass 0.4 1.7 4.5 -1.7 -0.9 2.1 0.2 -0.7 -1.4
Waist circumference 0.8 2.9 8.8 -2.0 -1.1 3.0 1.9 -0.0 0.2
Number of incorrect matches in round 0.4 0.6 1.5 1.2 0.7 -1.2 -0.1 0.5 -0.0
Past tobacco smoking 0.9 1.7 4.2 0.5 0.5 -2.0 -1.1 -2.0 0.4
Alcohol usually taken with meals 1.2 1.9 3.9 1.7 1.7 -0.9 -2.0 0.2 -0.8
Nervous feelings 0.5 1.0 2.0 -0.4 -0.1 -0.4 1.4 1.4 1.3
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.1 6.2 -0.0 -0.1 0.2 2.5 1.7 1.8
Hearing difficulty/problems with background noise 0.3 0.5 2.1 0.1 0.1 -1.4 0.7 0.3 0.3
Hair/balding pattern: Pattern 2 1.1 1.4 4.2 -1.5 -1.1 2.0 0.9 -0.2 0.4
Had menopause 1.3 1.6 4.3 -1.2 -1.2 -0.8 -1.1 -2.1 -0.9
Had other major operations 0.9 1.1 4.0 2.0 1.2 -0.2 -0.3 1.0 0.4
Forced vital capacity (FVC) 0.2 0.7 1.7 0.6 0.6 0.9 -0.8 0.5 -1.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 0.7 0.5 0.8 -0.1 -0.1 -0.4
Ever unenthusiastic/disinterested for a whole week 1.1 1.3 3.1 -0.1 0.8 0.2 1.2 -1.6 1.8
Qualifications: None of the above 1.3 2.8 8.3 -2.2 -2.9 0.9 0.2 -1.4 0.6
Financial difficulties in last 2 years 1.8 2.4 8.5 1.3 1.5 -0.1 2.9 0.9 1.3
Mouth/teeth dental problems 0.4 0.5 1.9 1.0 1.4 -0.3 -0.5 0.1 -0.1
Heart attack 1.7 2.2 5.8 -1.1 -1.0 1.5 2.4 0.7 1.6
Allergy 0.5 1.1 2.1 0.8 1.2 1.4 -1.3 0.1 -1.1
Pain all over the body in last month 2.4 2.6 6.3 0.4 1.5 0.0 2.5 0.5 2.5
Diabetes (self-reported) 0.7 1.0 3.2 0.0 0.5 -0.1 -1.6 -0.6 -1.8
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.1 -0.6 -0.3 1.1 0.3 -1.5 0.4
Medication: Ramipril 0.8 1.1 2.7 -1.6 -1.3 1.0 0.8 0.1 0.6
Medication: Simvastatin 0.2 0.3 1.4 -0.1 1.2 0.3 0.4 0.2 0.1
Fluid intelligence score 1.4 2.9 6.2 -1.8 -0.3 2.5 2.4 1.2 0.7
Illnesses of siblings 1.0 1.4 3.6 0.1 0.8 0.0 1.9 1.0 1.8
Neuroticism score 1.2 2.5 6.4 -1.5 -1.6 1.2 2.5 -0.0 1.5
Weight 0.5 2.3 8.5 -1.7 -0.7 2.9 1.0 0.1 -0.8
Impedance of arm (right) 1.0 4.8 10.1 2.7 3.2 -2.9 -1.8 0.3 -0.1
Arm fat percentage (right) 0.5 1.8 4.7 -1.6 -1.1 2.2 0.3 -1.2 -0.9
Trunk fat-free mass 0.3 1.7 6.5 -0.4 0.2 2.5 0.7 1.8 -0.3
Hip circumference 0.5 2.2 8.3 -1.5 -0.6 2.9 1.3 0.4 -0.6
Time employed in main current job 1.3 1.5 3.6 -0.4 -0.3 -0.9 -1.8 -1.9 -0.9
Alcohol intake versus 10 years previously 0.4 0.6 1.5 0.3 0.7 0.3 1.2 0.9 0.6
Father’s age at death 0.3 0.4 1.8 -0.3 0.2 -0.5 -1.3 -0.6 0.1
Worrier / anxious feelings 0.4 0.7 3.0 -0.1 -0.1 0.2 1.7 -0.0 1.2
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 10.8 1.0 1.1 -3.3 -0.6 -0.8 -0.4
Falls in the last year 0.4 0.6 1.8 -0.6 -0.7 -1.4 -0.4 -0.7 -0.2
Hair/balding pattern: Pattern 3 0.3 0.5 1.5 0.6 0.4 -1.2 0.4 -0.3 0.7
Number of live births 0.2 0.3 1.5 -0.1 -0.3 -1.2 -0.0 -0.3 -0.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 2.2 0.1 0.4 1.5 -0.6 0.1 -0.8
Pulse rate 1.0 1.7 3.8 -1.7 -1.3 1.0 1.9 -0.7 0.7
Happiness 0.6 0.7 1.8 -0.2 0.2 -0.2 1.4 0.7 1.3
Noisy workplace 0.7 0.8 2.1 1.1 0.6 -1.0 -1.4 -0.7 0.1
Qualifications: A levels/AS levels or equivalent 0.8 1.7 4.0 0.4 2.0 -0.7 -1.3 1.3 -1.5
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 5.5 0.1 0.6 2.4 -0.8 0.8 -0.5
Mouth/teeth dental problems: Dentures 1.3 2.3 3.9 -2.0 -2.0 1.9 1.4 -0.4 0.2
Asthma 1.0 2.0 5.2 -1.0 -0.8 -0.7 2.2 0.3 2.3
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.0 3.1 1.2 0.8 -1.8 0.2 0.1 -1.0
Medication: Cholesterol lowering 1.0 1.5 2.8 1.0 1.7 0.7 0.7 1.5 1.5
Depression (self-reported) 1.1 1.4 3.8 -1.0 -0.5 -0.7 2.0 -1.1 1.2
Medication: Lansoprazole 0.6 0.7 2.0 -0.3 -0.2 0.2 -0.8 1.1 -1.4
Prospective memory result 1.5 1.8 6.0 2.5 1.3 -1.2 -1.3 0.2 -0.2
Lung cancer (father) 1.3 1.5 3.0 0.5 -0.1 1.7 1.7 0.7 1.6
Illnesses of mother 2.9 3.6 5.4 -2.3 -0.9 2.1 1.9 -1.6 2.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.4 2.6 1.1 1.4 1.6 -0.5 1.3 -1.0
Pulse wave Arterial Stiffness index 1.0 1.2 3.7 -1.2 -0.4 1.0 1.9 0.1 0.8
Impedance of arm (left) 1.2 5.7 11.6 3.0 3.4 -3.1 -1.6 0.8 -0.4
Arm fat mass (right) 0.6 2.3 7.8 -1.7 -1.1 2.8 0.4 -0.9 -0.9
Trunk predicted mass 0.3 1.7 6.5 -0.4 0.2 2.5 0.8 1.7 -0.2
Standing height 0.4 4.2 10.2 1.9 3.2 0.2 -0.7 3.1 -1.2
Length of working week for main job 0.6 0.7 1.9 -1.4 -0.7 0.7 0.7 -0.9 -0.4
Exposure to tobacco smoke at home 1.2 1.3 2.1 -1.4 -1.0 -0.8 1.1 -1.1 1.5
Breastfed as a baby 0.8 0.9 2.9 0.7 0.3 -0.9 -1.7 0.6 -1.0
Tense / ‘highly strung’ 0.4 0.6 1.7 0.8 0.5 -1.3 0.7 0.1 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 4.4 -0.4 0.9 -0.1 2.1 0.5 1.6
Hair/balding pattern: Pattern 4 0.2 0.5 1.2 0.1 -0.6 0.1 -0.6 1.0 -1.1
Birth weight of first child 0.2 0.3 0.6 -0.8 0.1 -0.5 0.4 0.6 -0.7
Peak expiratory flow (PEF) 0.3 0.8 3.9 -0.5 -0.1 2.0 -0.1 0.7 -0.4
Pulse wave reflection index 0.3 0.4 0.8 -0.6 -0.4 0.9 0.4 0.7 -0.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 0.3 -0.7 -0.6 -1.0 -0.6 -0.0
Loud music exposure frequency 0.2 0.2 0.6 0.1 -0.2 0.0 -0.0 0.8 0.7
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 1.8 1.0 1.3 -1.2 -0.7 0.2 -1.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.9 -0.1 -0.4 -0.6 -0.9 -0.1 -0.2
Blood clot in the leg (DVT) 0.6 0.7 3.5 0.7 0.6 -1.9 0.4 0.1 -0.1
Medication: Paracetamol 0.4 0.7 1.4 1.2 0.6 -0.9 -1.1 -0.6 -0.6
Headache pain in last month 2.7 4.7 11.6 2.8 2.3 -3.4 -1.0 1.3 -0.8
Medication for cholesterol, blood pressure or diabetes 1.0 1.6 3.6 -1.1 -1.9 -0.7 -1.0 -1.4 -1.2
Glaucoma (self-reported) 1.7 2.0 4.8 2.2 1.8 -1.0 -1.3 1.0 -0.6
Gout (self-reported) 0.3 0.4 1.4 0.5 0.1 0.2 1.2 0.5 0.8
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 -0.9 -0.3 0.7 0.8 -0.4 -0.6
Medication: Amlodipine 0.5 0.7 1.7 -0.8 -1.1 1.3 0.4 -0.4 0.1
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 0.9 1.2 -1.0 -0.3 -0.1 1.1
Birth weight 0.4 0.8 1.2 0.8 1.0 -0.2 -1.1 1.0 -1.0
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 -0.1 -0.8 -0.5 -0.9 -0.9 -0.7
High blood pressure (siblings) 1.7 2.4 8.4 1.5 0.1 0.0 -2.9 0.7 -1.8
Forced vital capacity (FVC), Best measure 0.3 1.2 1.7 1.2 1.0 1.3 -0.4 1.2 -1.2
Body fat percentage 0.4 1.7 3.7 -1.6 -1.0 1.9 0.2 -1.3 -1.1
Leg fat percentage (right) 0.4 1.3 2.3 -1.5 -0.8 1.5 1.4 -0.9 0.0
Arm fat-free mass (right) 0.4 2.0 7.7 -1.2 -0.9 2.8 0.6 0.8 -0.9
Exposure to tobacco smoke outside home 0.6 0.8 3.0 -0.2 -0.5 0.8 0.7 -0.6 1.7
Comparative body size at age 10 1.1 3.1 7.0 -1.9 -2.6 2.0 0.9 1.1 -1.3
Number of full brothers 2.9 3.7 6.1 1.5 1.5 -0.2 2.4 2.3 2.5
Worry too long after embarrassment 1.4 2.4 5.5 -2.3 -1.7 1.1 1.5 -0.7 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.7 2.0 -0.4 0.1 -0.8 0.3 -1.2 1.4
Wheeze or whistling in the chest in last year 0.1 0.1 0.3 0.4 0.1 -0.6 0.2 0.2 0.2
Number of children fathered 2.3 2.5 7.2 0.7 0.6 -0.5 -2.7 -1.2 -2.3
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 3.1 -0.2 -0.5 0.7 -1.2 -1.8 -1.1
Age at first live birth 0.9 1.6 4.2 1.1 2.0 0.2 -0.1 1.9 -0.9
Pulse wave peak to peak time 1.2 1.4 3.9 1.4 0.6 -1.0 -2.0 0.2 -1.0
Health satisfaction 0.3 0.4 1.5 -0.5 -0.3 0.3 0.6 -0.2 1.2
Shortness of breath walking on level ground 1.1 1.3 4.8 -0.7 -0.5 1.1 0.8 -0.9 2.2
Qualifications: College or University degree 0.2 0.7 1.5 0.1 1.2 -1.1 -0.6 -1.0 -0.2
Eye problems/disorders: None of the above 0.5 0.5 2.3 -0.4 -0.8 -0.3 -0.3 -1.5 -0.1
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.5 0.4 0.0 -0.5 -0.2 0.7 0.5
Emphysema/chronic bronchitis 2.2 2.5 4.9 -2.0 -2.2 1.0 1.9 -0.4 1.2
Medication for pain relief, constipation, heartburn 0.6 1.0 2.4 -1.6 -1.0 1.0 -0.1 1.1 -0.3
Neck or shoulder pain in last month 0.3 0.4 0.9 -0.8 -0.4 -0.9 0.1 -0.5 -0.6
Medication: Blood pressure 0.7 1.3 2.0 0.8 1.1 1.2 1.4 1.4 0.7
Angina (self-reported) 0.9 1.2 3.5 1.3 1.9 -0.7 0.2 1.0 0.9
Migraine (self-reported) 0.4 0.5 1.7 0.8 1.3 -0.2 0.4 0.4 0.5
Medication: Ibuprofen 0.5 0.6 1.4 1.1 0.6 -1.0 0.1 0.2 -1.2
Medication: Allopurinol 0.5 0.7 1.5 1.2 0.4 -0.4 0.4 1.1 -1.0
Medication: Omeprazole 1.5 1.7 4.1 1.5 1.3 -2.0 0.9 -0.4 1.1
Medication: Seretide 50 evohaler 0.7 0.8 1.2 -0.5 -1.1 -1.0 -0.3 0.9 -1.0
Mean time to correctly identify matches 1.4 2.6 3.7 -1.8 -1.9 1.0 1.6 -1.7 1.5
Heart disease (mother) 0.6 0.7 1.8 0.5 1.2 -0.9 -0.2 0.2 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 5.2 -0.2 -1.1 -0.5 0.6 2.3 -0.8
Whole body fat mass 0.5 2.0 6.6 -1.6 -0.9 2.6 0.3 -0.7 -1.1
Leg fat mass (right) 0.4 1.7 6.2 -1.4 -0.5 2.5 1.1 -0.4 -0.5
Arm predicted mass (right) 0.5 2.5 8.8 -1.6 -1.1 3.0 0.8 0.7 -1.0
Pulse rate, automated reading 0.4 1.3 3.2 -1.0 -0.5 0.8 1.8 -1.2 1.1
Alcohol intake frequency. 0.5 1.1 3.2 -1.4 -1.0 -0.7 1.8 -0.3 -0.3
Comparative height size at age 10 0.3 1.4 3.6 0.9 1.6 1.1 0.6 1.9 0.1
Number of full sisters 0.2 0.3 1.0 -1.0 -0.2 -0.1 0.1 -0.6 0.7
Suffer from ‘nerves’ 0.4 0.6 1.2 -0.0 -0.1 0.8 0.9 1.0 1.1
Overall health rating 0.3 0.7 1.7 -0.5 0.1 -0.3 1.1 -0.7 1.3
Chest pain or discomfort 0.8 1.1 3.5 0.1 0.7 0.4 1.5 0.1 1.9
Had major operations 0.8 1.0 2.4 -1.5 -1.2 0.7 0.1 -1.2 0.5
Age at last live birth 0.5 0.7 1.8 0.7 1.4 -0.1 0.1 1.2 -0.4
Family relationship satisfaction 0.5 0.6 1.4 -0.5 -0.5 0.6 1.2 1.1 0.1
Leg pain on walking 0.2 0.2 0.8 -0.4 -0.0 -0.6 0.4 0.1 0.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.4 1.5 -0.2 -0.1 1.0 0.1 1.2 -0.3
Commuting to job workplace: Car/motor vehicle 1.4 1.6 5.2 0.1 -0.4 0.6 -1.7 -1.0 -2.3
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.5 -0.3 -0.5 0.7 -0.3 -0.3 -0.6
Medication: Aspirin 0.2 0.3 0.9 -0.5 -0.2 0.4 0.5 -1.0 -0.1
Supplements: Vitamin C 0.5 0.6 2.4 -0.2 -0.5 0.7 1.5 0.7 0.4
Knee pain experienced in last month 0.5 0.8 2.2 1.4 1.5 -0.5 -0.2 0.3 -0.4
Hypertension (Self-reported) 0.2 0.5 1.2 0.4 1.1 -0.7 0.2 1.0 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 6.7 1.6 1.9 -2.6 0.8 0.8 1.0
Illnesses of father: Heart disease 1.7 2.3 5.2 1.0 1.1 -1.6 -1.7 1.0 -2.3
Illnesses of siblings: Diabetes 0.8 0.9 1.3 -0.7 -1.1 0.9 -1.2 -1.0 -0.9
Smoking status: Previous 0.8 1.2 4.0 -0.3 -0.3 1.4 0.8 2.0 -0.6
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 5.3 1.7 2.3 -1.3 -1.1 1.1 -0.6
Whole body fat-free mass 0.3 1.9 8.5 -0.7 -0.0 2.9 0.8 1.3 -0.5
Leg fat-free mass (right) 0.4 2.3 11.6 -0.9 -0.0 3.4 0.9 0.8 -0.4
Arm fat percentage (left) 0.5 1.9 5.1 -1.7 -1.1 2.2 0.5 -1.1 -0.9
Average weekly red wine intake 0.7 1.0 3.3 -0.2 -0.1 -1.8 -1.1 0.8 -0.9
Handedness (chirality/laterality): Left-handed 2.0 2.4 7.0 -1.8 -2.7 1.1 0.9 -0.6 -1.3
Mood swings 0.3 0.6 1.9 -0.5 -1.4 0.3 0.5 0.6 -0.7
Loneliness, isolation 0.6 0.8 2.5 -1.2 -1.6 0.1 0.1 -0.5 0.8
Long-standing illness, disability or infirmity 0.5 0.8 2.0 -1.1 0.4 -0.2 1.4 0.4 1.1
Ever had bowel cancer screening 0.1 0.2 0.8 -0.3 0.1 0.2 -0.9 -0.1 -0.3
Diabetes diagnosed by doctor 0.6 1.0 2.6 -0.0 0.5 0.2 -1.6 -0.8 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.1 -0.2 -0.3 1.1 0.5 0.7 0.2
Friendships satisfaction 1.3 1.6 6.1 -0.3 -0.2 0.1 1.6 2.5 0.8
Qualifications: nursing, teaching 2.0 3.2 10.8 0.3 0.3 -0.6 -2.7 -0.5 -3.3
Commuting to job workplace: Walk 0.3 0.3 0.9 0.1 0.7 -0.2 0.6 -0.3 0.9
Eye problems/disorders: Cataract 0.5 0.6 1.6 0.3 1.0 0.2 0.8 1.3 0.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.3 1.5 1.3 -1.3 -0.5 0.8 -0.6
Medication for cholesterol 0.2 0.4 1.0 0.4 -0.2 -0.6 -1.0 -0.7 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 1.4 1.1 1.2 -0.6 -0.5 0.7 0.7
Back pain experienced in last month 0.8 1.2 3.4 0.6 0.3 -1.8 -0.7 -0.4 -1.6
Mineral and other dietary supplements 0.7 0.9 3.1 -1.2 -0.2 1.8 -0.5 0.6 -0.2
Breast cancer (self-reported) 0.6 0.8 1.4 0.9 0.4 -0.8 -0.9 1.2 -1.0
Asthma (self-reported) 1.3 2.7 7.5 -0.9 -0.8 -1.1 2.4 0.3 2.7
Osteoporosis (self-reported) 0.3 0.4 1.6 -0.4 -0.3 -0.4 1.2 0.6 0.2
Osteoarthritis (self-reported) 0.6 0.7 1.3 -0.9 -0.7 0.6 1.1 -1.1 -0.2
Medication: Aspirin 0.5 0.7 1.6 -1.0 -0.5 0.7 0.7 -1.2 -0.2
Medication: Gliclazide 1.4 1.6 5.5 -0.2 0.1 1.6 -1.3 0.1 -2.3
Illnesses of father: None of the above (group 1) 2.6 3.2 10.0 -0.5 -0.0 1.2 2.7 -0.6 3.2
Smoking status: Current 0.7 1.1 2.4 0.5 1.2 0.2 1.4 0.7 1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 1.5 -0.3 -0.5 1.2 -0.5 -0.6 -0.3
Whole body water mass 0.3 2.0 8.8 -0.8 -0.1 3.0 0.7 1.2 -0.6
Leg predicted mass (right) 0.4 2.3 11.4 -0.8 -0.0 3.4 0.8 0.8 -0.4
Arm fat mass (left) 0.6 2.4 7.3 -1.9 -1.2 2.7 0.3 -0.8 -1.1
Number of self-reported non-cancer illnesses 0.2 0.4 0.9 0.0 1.0 -0.9 0.2 0.2 0.5
Average weekly champagne plus white wine intake 2.6 3.5 8.6 2.4 2.9 -2.1 -0.1 1.0 1.3
Miserableness 0.4 0.7 1.8 -0.1 -1.1 -0.4 1.4 0.6 0.8
Guilty feelings 2.3 3.4 7.7 -2.8 -2.2 2.3 1.4 -0.6 -0.7
Wears glasses or contact lenses 2.2 2.6 7.7 -1.9 -1.4 1.3 0.1 -2.8 0.8
Ever taken oral contraceptive pill 3.0 3.3 7.3 2.7 2.2 -1.8 -0.1 2.0 0.7
Hearing aid user 3.4 3.8 10.2 -0.6 -1.8 -0.4 -2.9 -0.8 -3.2
Mother’s age at death 0.2 0.2 0.9 -0.3 -0.4 -0.5 -0.3 -0.9 0.3
Financial situation satisfaction 1.2 1.4 3.2 1.8 1.6 -1.3 0.0 0.9 -0.4
Tinnitus: Yes, now most or all of the time 1.6 1.9 3.8 -1.3 -0.1 1.1 1.9 -1.6 1.4
Commuting to job workplace: Public transport 0.6 0.7 1.3 -0.8 -0.9 0.0 0.8 -0.7 1.1
Eye problems/disorders: Glaucoma 2.4 2.9 7.4 2.7 1.9 -1.0 -1.3 1.8 -0.4
Medication: Blood pressure 0.3 0.6 1.9 0.0 0.5 -0.6 0.8 1.4 -0.6
Pain type(s) experienced in last month: Hip pain 0.6 0.7 3.0 0.3 0.5 0.4 1.7 0.6 0.7
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.9 0.9 0.1 -1.7 0.9 0.2 -0.1
High cholesterol (Self-reported) 0.3 0.5 1.3 -1.1 -0.3 0.7 1.1 0.1 -0.1
Medication: Bendroflumethiazide 0.4 0.6 0.9 -0.6 0.3 0.9 0.8 0.9 0.8
Medication: Paracetamol 0.4 0.7 1.1 1.0 0.5 -0.7 -1.0 -0.4 -1.1
Medication: Lisinopril 0.7 0.9 3.2 0.9 0.6 -1.8 0.8 0.8 0.1
Medication: Atorvastatin 0.3 0.3 0.7 0.3 0.5 0.5 0.5 0.8 0.6
Illnesses of father: High blood pressure 0.7 0.9 2.1 -1.0 -0.8 0.8 -0.4 0.9 -1.4
Alcohol drinker status: Never 1.4 1.7 5.6 -0.6 0.0 -0.4 2.4 1.0 1.7
Ever smoked 0.9 1.6 5.5 -0.3 -0.5 1.8 0.7 2.3 -0.0
Basal metabolic rate 0.4 2.0 9.2 -0.9 -0.1 3.0 0.8 1.1 -0.6
Leg fat percentage (left) 0.6 2.1 4.1 -1.9 -1.3 2.0 1.3 -1.3 -0.1
Arm fat-free mass (left) 0.5 2.3 8.9 -1.6 -1.0 3.0 0.5 0.6 -0.9
Number of operations (self-reported) 0.3 0.5 1.6 0.0 0.5 1.0 -0.2 -1.3 -0.2
Average weekly beer plus cider intake 0.2 0.2 0.7 0.2 -0.6 0.1 0.4 0.1 0.8
Irritability 1.2 2.0 7.6 -1.6 -2.8 1.0 0.6 -0.0 -0.8
Risk taking 0.7 1.0 2.2 -0.6 -0.9 -0.1 1.4 0.9 1.5
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.0 0.9 0.8 -0.4 0.2 -0.6 1.0
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.4 0.9 -0.8 0.2 0.2 0.6
Age started oral contraceptive pill 0.8 1.0 3.1 -0.5 -0.6 -0.6 -1.1 0.8 -1.8
Diastolic blood pressure, automated reading 0.5 1.4 4.3 2.1 1.7 -0.8 -0.4 0.8 -0.5
Ever depressed for a whole week 2.3 2.8 7.4 -0.8 -0.4 1.3 2.6 -0.2 2.7
Unable to work because of sickness or disability 0.7 0.9 2.4 -0.8 -0.2 0.2 1.5 0.2 1.5
Commuting to job workplace: Cycle 1.3 1.6 4.5 -0.9 -0.3 -0.1 2.1 0.3 2.0
Myopia 0.3 0.4 1.1 -1.1 -0.2 0.2 -0.5 -1.0 0.2
Vascular/heart problems diagnosed by doctor 0.1 0.4 1.1 -0.1 -0.7 -0.2 -0.7 -1.1 -0.4
Cholesterol lowering medication 0.4 0.6 1.1 -1.1 -0.5 0.9 0.5 -0.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 2.9 1.7 1.3 -1.4 1.1 -0.7 1.7
Pain experienced in last month 1.3 2.2 4.6 -2.1 -1.8 1.9 0.1 -0.8 0.7
Supplements: Calcium 0.3 0.3 1.2 -0.5 -0.3 -1.1 0.7 0.1 0.1
Basal cell carcinoma (self-reported) 0.8 0.9 3.3 -0.0 0.6 -1.8 1.0 -0.9 0.2
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.8 -1.0 -0.9 1.3 2.4 0.7 1.7
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.8 0.1 0.1 -1.7 0.2 -0.1 -0.2
Heart disease (siblings) 0.2 0.3 0.8 0.0 -0.4 -0.6 0.5 -0.3 0.9
Alcohol drinker status: Previous 1.6 1.8 5.9 -2.4 -1.7 0.2 1.1 -0.0 -0.9
Pack years of smoking 2.1 3.1 11.6 0.1 0.6 -0.8 2.5 0.2 3.4
Impedance of whole body 0.8 4.2 10.1 2.4 2.5 -3.2 -1.7 0.6 -0.5
Leg fat mass (left) 0.6 2.2 8.0 -1.7 -0.9 2.8 0.9 -0.7 -0.6
Arm predicted mass (left) 0.4 2.1 8.5 -1.4 -0.9 2.9 0.7 0.6 -0.6