Hub : Genes

RASA1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.054	0.0240	2.8e-03	-0.001	0.023	0.004	0.023	0.002	0.420	6.7e-04	8.9e-02	6.4e-04	1.5e-01
2	GTEx	Cells Transformed fibroblasts	0.114	0.0490	7.8e-03	0.019	NA	0.037	NA	0.021	0.014	NA	8.8e-04	NA	9.7e-03
3	ROSMAP	Brain Pre-frontal Cortex	0.101	0.0345	2.2e-05	0.010	0.052	0.043	0.053	0.035	0.017	2.5e-07	2.5e-06	2.1e-07	2.3e-05
4	TCGA	Bladder Urothelial Carcinoma	0.038	0.0270	7.2e-03	0.012	-0.002	0.006	NA	0.010	0.030	4.8e-01	9.3e-02	NA	4.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.1	0.1	0.2	0.2	0.2	0.4	0.2
Bipolar Disorder or Schizophrenia	0.9	2.1	6.0	1.0	-2.4	0.9	-0.8
Depressed Affect (Nagel 2018)	2.3	4.9	12.8	3.6	0.3	2.5	-0.8
Depression (Nagel 2018)	2.4	3.6	7.1	2.7	-0.0	2.7	0.4
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.8	0.0	0.4	0.1	0.9
Neuroticism (Nagel 2018)	2.2	5.2	16.1	4.0	-0.3	1.9	-0.9
Schizophrenia (2018)	1.7	3.6	10.9	1.1	-3.3	0.9	-1.3
Schizophrenia vs Biploar Disorder	1.8	2.4	3.9	-1.3	-1.7	1.0	2.0
Worry (Nagel 2018)	2.0	4.1	13.9	3.7	0.0	1.3	-1.0
Alzheimer’s Disease (in mother)	4.1	4.8	9.3	-3.0	-1.2	-1.8	2.3
Alzheimer’s Disease (in father)	0.4	0.4	0.8	-0.6	0.7	-0.9	-0.0
Alzheimer’s Disease (including proxy)	2.5	3.7	8.1	-2.9	-0.7	-1.8	1.7
Crohns Disease (2017)	0.6	1.3	2.8	1.3	0.2	1.7	-0.8
Irritable Bowel Disease (IBD)	0.4	0.8	1.9	1.4	-0.1	1.0	-0.7
Ulcerative Colitis (UC)	0.1	0.2	0.7	0.9	-0.2	-0.0	-0.2
Major Depression (MDD)	2.6	3.2	7.1	2.7	-0.4	2.4	0.1
Reaction Time	0.9	1.7	4.4	-2.1	-1.5	-0.4	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.5	0.8	0.1	1.6	-0.8
Breast Cancer	0.1	0.2	0.5	-0.4	-0.0	0.0	0.7
Ovarian Cancer	0.4	0.5	1.1	1.0	0.2	1.0	0.2
Prostate Cancer	0.2	0.3	0.7	0.2	0.8	0.1	-0.6
Age at First Birth	0.7	1.0	2.1	1.4	-1.0	-0.9	0.0
Bipolar Disorder (2011)	0.5	0.5	1.3	0.1	0.7	-0.4	1.2
Body Mass Index (BMI) (2010)	2.0	2.7	8.2	1.6	-0.2	0.2	-2.9
Coronary Artery Disease (CAD)	0.0	0.0	0.1	0.1	0.0	-0.2	0.2
Crohns Disease (2012)	0.3	0.5	1.7	-0.0	-0.1	1.3	0.5
Mean Putamen Volume	0.7	0.8	1.1	-1.0	-1.0	-1.0	0.4
Fasting Glucose	0.1	0.1	0.3	-0.2	0.6	-0.3	0.4
HbA1C	0.5	0.5	1.3	-0.1	-1.2	-0.2	-0.9
HDL Cholesterol	0.1	0.1	0.3	-0.5	0.0	0.5	-0.2
LDL Cholesterol	0.4	0.6	1.3	-0.7	-0.4	-1.1	0.6
Lupus	0.5	0.8	1.5	-0.9	0.9	-0.5	-1.2
Neuroticism (2016)	0.7	0.9	2.0	1.3	-0.1	1.4	0.0
Primary Biliary Cirrhosis	0.7	1.0	2.3	-0.5	-1.5	-1.2	-0.1
Rheumatoid Arthritis	0.4	0.5	1.0	-0.4	1.0	-0.9	-0.1
Schizophrenia (2014)	1.5	3.2	7.3	1.3	-2.7	1.6	-1.2
Triglycerides	0.1	0.1	0.3	0.6	-0.1	-0.2	-0.2
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.6	1.0	0.6	-0.2	-1.9
Ulcerative Colitis	0.3	0.5	0.8	0.9	0.5	0.2	-0.8
Blood Eosinophil Count	0.2	1.6	5.0	0.4	-1.0	-0.6	-2.2
Blood Platelet Count	0.4	4.8	9.7	-1.5	-3.1	1.4	-2.2
Blood Red Count	0.7	6.5	10.8	0.3	-3.3	2.6	-2.9
Blood White Count	0.4	2.8	4.8	-2.0	-2.2	-0.7	-1.4
Heel T-Score	0.2	1.8	2.5	-1.5	-1.6	-1.6	0.0
BMI	1.7	10.1	35.0	1.4	-1.7	-0.7	-5.9
Height	0.6	11.1	28.4	-3.7	1.4	-5.3	-0.6
Waist Hip Ratio (WHR)	0.2	1.1	1.7	-0.8	-1.3	-0.6	-1.2
Systolic Blood Pressure	0.2	0.9	1.9	-1.1	0.7	-0.4	-1.4
Smoking Status	0.1	0.3	0.5	-0.5	0.7	-0.7	-0.3
Allergy or Eczema	1.0	2.5	5.8	-2.4	-0.8	-1.9	-0.3
Cardiovascular Disease	0.2	0.5	1.0	-0.7	-0.8	-0.1	-1.0
Hypothyroidism (self reported)	2.5	5.7	15.1	3.9	0.8	1.4	-2.3
Respiratory disease	1.0	2.1	5.1	-0.8	-0.2	-2.3	-1.7
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.8	1.0	-0.4	1.4	-0.6
Lung FEV1/FVC ratio	0.3	1.4	3.6	-1.1	1.9	0.9	0.3
Lung FVC	0.6	3.1	5.3	1.4	0.9	2.3	2.1
Neuroticism	2.6	6.3	20.2	4.5	0.2	2.2	-0.6
Chronotype (morning person)	2.5	5.7	11.6	3.4	0.2	1.9	-2.7
Hair Pigment	0.0	1.3	4.0	-0.5	-0.1	-2.0	0.9
Tanning	0.0	0.5	1.5	-0.6	-0.2	-0.2	1.2
Hand grip strength (left)	0.9	2.3	4.6	-1.6	2.1	-1.4	-0.2
Number of treatments/medications taken	0.7	1.2	4.5	0.2	-0.1	-0.4	-2.1
Average weekly spirits intake	0.7	0.9	2.4	-0.8	-0.7	-1.5	0.4
Sensitivity / hurt feelings	1.1	2.0	3.8	1.9	-1.3	0.3	-1.5
Frequency of depressed mood in last 2 weeks	1.0	1.5	3.1	1.8	-0.3	1.3	1.0
Hearing difficulty/problems: Yes	0.2	0.3	1.1	-1.1	-0.3	-0.2	-0.3
Relative age of first facial hair	0.5	1.0	2.9	-0.7	0.9	0.3	1.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.8	-0.4	-1.7	-0.1	-1.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.6	-0.4	-0.7	0.6	0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	0.5	0.1	0.3	-0.2
Systolic blood pressure, automated reading	0.6	1.7	6.4	-0.4	-0.3	-0.5	-2.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.9	0.2	-0.9	-0.6	-0.8
Angina	3.6	4.7	9.4	2.7	1.0	3.1	-1.1
Medication for hormone replacement therapy	0.3	0.4	0.8	0.9	0.6	0.7	0.2
Vitamin and mineral supplements	0.8	1.0	2.7	-1.6	0.3	-0.0	1.2
Supplements: Zinc	0.7	0.7	1.8	-1.3	-0.5	-0.8	-0.5
Medication: Co-codamol	0.8	1.0	2.1	-1.4	0.5	-1.2	0.4
Medication: Metformin	0.5	0.7	2.0	0.7	-0.0	0.5	-1.4
Diabetes (father)	0.2	0.2	0.5	-0.7	-0.3	-0.6	0.1
Diabetes (mother)	1.0	1.3	1.8	1.1	1.4	0.9	-1.2
Severe depression (siblings)	2.2	2.5	7.1	0.5	-2.7	-0.9	-1.4
Pack years adult smoking proportion	0.6	0.9	2.0	-0.3	1.4	-1.2	0.1
Impedance of leg (right)	0.7	3.4	10.4	-0.6	1.2	1.1	3.2
Leg fat-free mass (left)	1.0	5.5	13.7	-0.5	0.3	-2.8	-3.7
Trunk fat percentage	1.3	5.4	18.8	0.8	-0.5	-1.3	-4.3
Hand grip strength (right)	1.2	3.2	7.3	-1.6	2.7	-1.6	-0.1
Townsend deprivation index at recruitment	0.4	0.6	1.0	-0.2	-1.0	0.7	0.9
Current tobacco smoking	0.9	1.5	5.4	-0.7	-0.3	-0.2	-2.3
Average weekly fortified wine intake	1.7	2.0	3.1	1.8	-1.7	0.9	-1.0
Maternal smoking around birth	0.7	1.0	3.6	-1.9	-0.3	-0.6	-0.1
Fed-up feelings	1.1	2.1	4.5	2.1	-0.1	1.9	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.6	5.5	2.3	-0.3	2.2	0.1
Relative age voice broke	0.9	1.3	3.3	0.0	1.2	0.6	1.8
Taking other prescription medications	0.5	0.8	2.2	1.0	-0.2	0.1	-1.5
Age when periods started (menarche)	3.2	7.6	18.7	-4.3	-1.6	-2.7	1.4
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.5	-1.2	0.8	-0.1	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.9	0.2	-0.4	-1.4	0.1
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.3	-0.1	0.5	-0.5	0.3
Qualifications: CSEs or equivalent	1.0	1.3	2.6	-1.6	-0.1	-1.5	0.6
Serious illness, injury or assault to yourself	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1
High blood pressure	0.4	1.0	3.0	-0.5	-0.9	-0.0	-1.7
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.0	-1.4	-1.1	-0.8	-0.0
Multivitamins +/- minerals	1.2	1.5	2.7	1.6	-0.8	0.1	-1.6
Stomach or abdominal pain in last month	0.3	0.4	1.0	0.3	-0.4	1.0	-0.6
Supplements: Glucosamine	0.8	1.1	2.4	-0.7	-1.6	-1.2	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	1.4	-0.6	0.8	-0.9	-1.2
Medication: Atenolol	0.4	0.5	1.8	-0.4	0.1	0.3	-1.3
Medication: Levothyroxine sodium	2.6	4.4	11.7	3.4	0.6	0.9	-2.2
Sitting height	0.7	5.1	12.7	-2.3	1.5	-3.6	0.5
Chronic bronchitis/emphysema (father)	0.6	0.7	2.0	0.2	0.1	-1.0	1.4
High blood pressure (mother)	0.4	0.5	1.3	0.3	0.6	-0.5	-1.2
Body mass index (BMI)	1.4	5.8	20.2	0.4	-1.3	-1.0	-4.5
Impedance of leg (left)	0.6	3.1	9.9	-1.3	0.7	0.4	3.1
Leg predicted mass (left)	1.0	5.3	13.0	-0.5	0.4	-2.8	-3.6
Trunk fat mass	1.6	6.9	23.2	0.3	-0.4	-2.0	-4.8
Waist circumference	1.4	5.1	16.7	0.2	-1.6	-1.1	-4.1
Number of incorrect matches in round	0.4	0.7	1.2	1.0	1.1	0.3	-0.6
Past tobacco smoking	0.3	0.5	1.1	-0.7	-1.1	-0.5	-0.3
Alcohol usually taken with meals	0.6	1.0	2.0	1.4	0.4	1.3	-0.2
Nervous feelings	1.5	2.7	5.1	2.3	0.9	2.1	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	2.3	1.5	-0.2	0.6	0.1
Hearing difficulty/problems with background noise	0.3	0.5	1.6	0.2	0.1	0.6	-1.3
Hair/balding pattern: Pattern 2	0.6	0.8	1.6	0.9	0.8	1.3	-0.3
Had menopause	2.4	3.0	5.9	2.4	-0.6	2.3	-0.8
Had other major operations	0.2	0.2	0.5	0.7	-0.5	0.2	0.0
Forced vital capacity (FVC)	0.5	1.8	6.9	-0.1	2.6	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.1	1.1	-0.7	-0.5	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	0.9	1.0	1.3	-0.3
Qualifications: None of the above	0.9	2.0	3.4	0.6	-1.3	1.5	-1.8
Financial difficulties in last 2 years	0.6	0.8	2.0	0.8	-0.6	1.4	-0.6
Mouth/teeth dental problems	0.9	1.3	2.7	1.6	0.8	1.3	-0.5
Heart attack	3.6	4.7	8.3	2.9	1.0	2.8	-1.1
Allergy	0.5	1.2	3.0	1.7	0.3	1.3	0.3
Pain all over the body in last month	1.4	1.5	3.0	-1.4	1.0	-1.7	0.1
Diabetes (self-reported)	0.2	0.3	0.6	0.4	-0.8	-0.0	-0.6
Hayfever/allergic rhinitis (self-reported)	1.7	2.2	8.5	-2.9	-0.3	-0.6	0.3
Medication: Ramipril	2.6	3.4	6.4	1.9	1.7	2.5	-0.8
Medication: Simvastatin	0.3	0.4	0.9	0.7	-0.1	0.4	-1.0
Fluid intelligence score	0.2	0.4	1.3	0.1	-0.3	1.1	-0.5
Illnesses of siblings	0.3	0.4	0.9	-0.2	0.4	-0.8	-1.0
Neuroticism score	1.5	3.2	9.3	3.1	0.7	1.7	-0.2
Weight	1.4	6.8	19.7	-0.5	-0.4	-2.6	-4.4
Impedance of arm (right)	0.2	0.8	2.5	0.6	0.4	0.6	1.6
Arm fat percentage (right)	1.5	6.0	20.4	0.4	-1.5	-1.1	-4.5
Trunk fat-free mass	0.7	4.1	7.8	-1.5	0.1	-2.8	-2.5
Hip circumference	1.0	4.3	13.7	0.3	-0.9	-1.6	-3.7
Time employed in main current job	0.4	0.5	0.7	0.5	0.8	0.7	0.8
Alcohol intake versus 10 years previously	0.7	1.1	3.4	-1.9	0.0	-0.4	0.8
Father’s age at death	1.0	1.3	2.8	1.7	-0.5	1.2	0.9
Worrier / anxious feelings	1.3	2.4	4.1	2.0	-1.3	0.5	-1.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.8	-0.5	-0.2	-0.5
Falls in the last year	1.3	1.7	6.3	-0.1	-2.5	0.3	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.0	-0.7	0.8	-0.5
Number of live births	0.4	0.6	2.3	-0.3	-1.5	0.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	6.7	0.1	2.6	0.6	0.8
Pulse rate	1.8	3.1	4.6	-2.1	-1.2	-1.8	-1.7
Happiness	0.4	0.4	0.8	-0.9	-0.5	0.2	0.8
Noisy workplace	1.7	2.1	3.2	-1.6	-1.8	-1.3	1.0
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.5	0.3	-0.4	-0.7
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	7.7	1.4	-0.7	-0.3	-2.8
Mouth/teeth dental problems: Dentures	0.6	1.0	3.5	0.4	-1.9	0.5	-0.1
Asthma	1.9	3.8	6.7	-2.2	-0.3	-2.6	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	6.3	-2.5	0.5	-2.0	-0.7
Medication: Cholesterol lowering	0.3	0.5	0.6	-0.7	0.6	-0.6	-0.8
Depression (self-reported)	1.0	1.1	1.6	1.0	-1.1	1.3	0.9
Medication: Lansoprazole	1.0	1.2	2.3	-1.0	-0.6	1.5	1.0
Prospective memory result	4.3	5.2	11.7	3.4	-0.5	3.0	0.1
Lung cancer (father)	0.4	0.5	1.3	0.6	1.1	-0.4	-0.3
Illnesses of mother	0.2	0.3	0.7	-0.9	-0.0	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	6.2	-0.0	2.5	0.8	1.2
Pulse wave Arterial Stiffness index	2.2	2.5	7.4	1.4	0.7	2.7	-0.7
Impedance of arm (left)	0.1	0.6	1.2	0.6	0.8	0.1	1.1
Arm fat mass (right)	1.4	5.7	19.4	-0.0	-0.9	-1.6	-4.4
Trunk predicted mass	0.7	3.9	7.4	-1.5	0.2	-2.7	-2.5
Standing height	0.6	6.1	15.5	-2.2	2.0	-3.9	-0.5
Length of working week for main job	1.4	1.6	5.2	-2.3	0.5	-0.7	0.6
Exposure to tobacco smoke at home	1.2	1.4	3.1	-1.0	-1.7	0.5	1.1
Breastfed as a baby	0.6	0.7	2.0	-0.7	1.4	-0.6	-0.3
Tense / ‘highly strung’	1.8	3.0	7.7	2.8	0.9	1.8	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	0.7	-0.1	0.6	1.1
Hair/balding pattern: Pattern 4	0.7	1.6	4.4	-0.3	-0.6	-1.3	2.1
Birth weight of first child	1.2	2.1	3.1	1.7	1.8	1.1	-1.1
Peak expiratory flow (PEF)	1.7	3.9	12.8	0.4	3.6	1.6	-0.4
Pulse wave reflection index	0.8	1.0	2.6	1.1	-0.2	1.6	-0.3
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.8	1.7	0.4	1.4	0.6
Loud music exposure frequency	0.9	1.0	2.0	-1.4	0.3	-0.6	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	0.8	0.1	1.3	-0.4
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.2	0.1	2.3	-0.6	-1.1
Blood clot in the leg (DVT)	1.4	1.8	4.0	-0.0	1.4	1.1	2.0
Medication: Paracetamol	1.8	2.9	4.8	-1.9	-1.7	-2.2	-0.9
Headache pain in last month	0.2	0.3	0.7	0.1	-0.8	0.5	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.6	-0.2	-0.8	-0.5	0.3
Glaucoma (self-reported)	0.2	0.3	0.9	-0.4	0.2	-0.2	0.9
Gout (self-reported)	1.4	2.0	3.6	1.6	-0.1	1.3	-1.9
Hypothyroidism/myxoedema (self-reported)	3.5	6.9	16.8	4.1	0.1	1.1	-3.1
Medication: Amlodipine	0.6	0.9	3.0	0.0	-0.7	0.2	-1.7
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.3	0.0	1.5	-0.9	-0.6
Birth weight	0.8	1.8	2.9	1.7	1.7	-0.4	-1.0
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.0	-0.6	1.0	-0.4	1.0
High blood pressure (siblings)	0.5	0.7	2.0	-0.8	-0.1	0.2	1.4
Forced vital capacity (FVC), Best measure	0.5	1.9	6.3	-0.1	2.5	0.3	1.1
Body fat percentage	1.4	5.4	19.2	0.7	-0.9	-1.0	-4.4
Leg fat percentage (right)	1.3	4.9	17.6	0.5	-1.2	-0.6	-4.2
Arm fat-free mass (right)	0.6	3.2	6.2	-1.0	0.5	-2.4	-2.5
Exposure to tobacco smoke outside home	1.0	1.3	3.1	-1.2	-0.3	-0.9	-1.8
Comparative body size at age 10	1.3	3.5	8.3	1.3	-1.9	0.6	-2.9
Number of full brothers	0.7	0.8	1.5	-1.2	0.8	-0.7	0.9
Worry too long after embarrassment	0.3	0.5	1.1	1.0	-1.1	-0.1	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.2	2.4	1.5	-0.6	1.2	-0.7
Wheeze or whistling in the chest in last year	0.7	1.3	3.6	0.4	1.2	-0.2	-1.9
Number of children fathered	0.6	0.7	1.9	0.6	0.3	1.4	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.7	0.8	-0.2	0.8	0.0
Age at first live birth	0.5	0.8	2.5	0.4	-0.5	-1.6	-0.5
Pulse wave peak to peak time	2.4	2.9	8.1	-1.6	-0.6	-2.9	0.7
Health satisfaction	0.6	0.7	2.7	0.4	1.6	-0.2	0.2
Shortness of breath walking on level ground	0.5	0.6	2.0	0.2	1.4	0.6	-0.2
Qualifications: College or University degree	0.1	0.5	1.1	-1.1	-0.5	-0.7	0.1
Eye problems/disorders: None of the above	0.5	0.6	1.1	-1.0	0.4	0.2	1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.0	-0.0	-0.7	-0.7	1.0
Emphysema/chronic bronchitis	2.0	2.2	4.8	2.0	-0.1	-0.5	-2.2
Medication for pain relief, constipation, heartburn	0.6	1.0	3.1	0.8	0.0	0.4	1.8
Neck or shoulder pain in last month	1.0	1.4	1.9	1.4	-1.4	0.8	-1.1
Medication: Blood pressure	0.4	0.7	1.0	0.7	0.9	0.6	-1.0
Angina (self-reported)	3.9	5.2	10.6	2.8	1.0	3.3	-1.1
Migraine (self-reported)	1.2	1.4	4.5	-2.1	-0.6	-1.0	0.0
Medication: Ibuprofen	2.3	2.7	8.1	-2.8	0.5	-1.5	-0.5
Medication: Allopurinol	1.2	1.6	3.3	1.5	-0.0	1.8	-1.0
Medication: Omeprazole	0.6	0.7	1.4	-1.2	-0.3	-1.1	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.2	0.4	0.6	1.1	-1.1
Mean time to correctly identify matches	0.3	0.5	0.9	-0.6	-0.9	0.7	-0.7
Heart disease (mother)	0.5	0.6	1.3	0.6	-0.7	1.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	4.4	0.3	0.6	-0.4	-2.1
Whole body fat mass	1.6	6.8	23.6	0.3	-0.6	-1.7	-4.9
Leg fat mass (right)	1.5	5.9	20.9	0.1	-0.7	-1.5	-4.6
Arm predicted mass (right)	0.7	3.8	7.1	-1.2	0.3	-2.5	-2.7
Pulse rate, automated reading	3.1	10.1	14.2	-2.4	-3.6	-3.8	-2.8
Alcohol intake frequency.	0.8	1.9	4.9	0.2	-0.7	2.2	1.6
Comparative height size at age 10	0.3	1.5	4.0	-0.9	0.5	-2.0	-1.0
Number of full sisters	0.2	0.2	0.6	-0.3	-0.2	0.8	-0.5
Suffer from ‘nerves’	3.0	4.7	8.4	2.9	2.4	2.1	0.6
Overall health rating	0.5	1.1	3.4	1.9	0.1	0.9	-0.5
Chest pain or discomfort	1.0	1.5	3.5	1.1	1.9	1.2	-0.2
Had major operations	0.6	0.8	1.4	0.4	0.8	1.2	-1.0
Age at last live birth	0.8	1.1	3.2	-0.0	-0.6	-1.8	-0.9
Family relationship satisfaction	0.2	0.2	0.4	0.6	0.3	0.5	0.5
Leg pain on walking	1.7	2.2	5.4	0.3	2.3	-1.3	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.7	-0.3	1.3	-1.1	0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.3	0.5	1.8	0.5	0.5
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.6	-0.9	1.2	-0.5	1.6
Medication: Aspirin	2.2	2.9	4.6	2.1	1.0	2.2	-1.3
Supplements: Vitamin C	1.0	1.1	2.0	-0.2	-1.4	-1.0	-1.2
Knee pain experienced in last month	0.2	0.3	1.1	0.1	-0.4	1.1	0.2
Hypertension (Self-reported)	0.3	0.8	1.8	-0.2	-0.9	0.5	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	1.4	1.1	1.1	1.2	0.4
Illnesses of father: Heart disease	4.0	5.6	10.4	2.8	1.9	3.2	-1.0
Illnesses of siblings: Diabetes	0.2	0.2	0.7	-0.2	-0.8	-0.1	-0.5
Smoking status: Previous	0.5	0.7	2.3	0.5	1.5	-0.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.1	-0.4	0.8	-1.8	-1.0
Whole body fat-free mass	0.8	4.4	9.1	-1.0	0.1	-2.8	-3.0
Leg fat-free mass (right)	1.1	6.0	13.0	-0.9	-0.1	-3.2	-3.6
Arm fat percentage (left)	1.6	6.5	22.2	0.4	-1.4	-1.4	-4.7
Average weekly red wine intake	0.6	0.8	1.6	1.1	0.8	0.2	-1.2
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	1.0	-0.5	0.1	-0.2
Mood swings	0.6	1.1	2.4	1.3	0.5	1.5	0.3
Loneliness, isolation	1.0	1.4	3.1	1.5	0.4	1.8	-0.1
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-0.7	-0.3	-1.1	-0.5
Ever had bowel cancer screening	2.3	2.7	3.8	1.5	-1.2	2.0	-1.8
Diabetes diagnosed by doctor	0.1	0.2	0.8	0.0	-0.3	-0.3	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.1	0.1	0.3	0.1	-0.3	0.1
Friendships satisfaction	1.1	1.3	3.0	1.7	0.1	1.3	-0.7
Qualifications: nursing, teaching	0.5	0.8	1.7	-0.7	0.8	-1.3	0.6
Commuting to job workplace: Walk	0.2	0.3	0.6	-0.6	-0.1	-0.2	0.8
Eye problems/disorders: Cataract	2.8	3.2	6.7	-1.2	-2.6	-2.2	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	2.6	-0.8	0.2	-0.6	1.6
Medication for cholesterol	0.2	0.3	0.9	-0.2	1.0	-0.3	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	2.3	1.5	1.0	1.0	-1.4
Back pain experienced in last month	1.0	1.4	4.0	1.1	0.3	2.0	0.6
Mineral and other dietary supplements	0.7	0.9	1.9	-0.8	1.0	0.2	1.4
Breast cancer (self-reported)	1.2	1.4	2.7	1.3	0.8	1.7	-0.9
Asthma (self-reported)	1.6	3.2	6.0	-2.0	-0.4	-2.5	-1.6
Osteoporosis (self-reported)	2.1	2.6	3.3	1.7	1.3	1.8	1.5
Osteoarthritis (self-reported)	1.5	2.0	4.0	-1.9	0.3	-2.0	-0.6
Medication: Aspirin	2.7	3.6	6.2	2.2	1.2	2.5	-1.3
Medication: Gliclazide	0.6	0.7	1.6	0.8	0.6	1.3	-0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-0.4	-0.4	-1.3	-0.6
Smoking status: Current	0.9	1.5	5.2	-0.6	-0.5	-0.4	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.8	1.3	0.5	1.7	-0.5
Whole body water mass	0.8	4.6	9.4	-1.1	0.3	-2.8	-3.1
Leg predicted mass (right)	1.1	5.9	12.7	-1.0	-0.2	-3.2	-3.6
Arm fat mass (left)	1.6	6.5	21.5	-0.0	-1.0	-1.9	-4.6
Number of self-reported non-cancer illnesses	1.3	2.3	4.6	-1.4	-1.2	-1.2	-2.1
Average weekly champagne plus white wine intake	0.6	0.9	1.8	-1.3	0.1	-1.1	0.6
Miserableness	0.5	0.8	1.6	1.3	-0.0	0.9	0.9
Guilty feelings	1.3	1.9	4.4	1.8	-0.0	2.1	0.5
Wears glasses or contact lenses	1.5	1.7	4.8	2.2	0.3	1.3	0.6
Ever taken oral contraceptive pill	2.8	3.1	4.1	-1.9	2.0	-2.0	1.0
Hearing aid user	0.2	0.2	0.5	-0.4	-0.7	-0.3	-0.0
Mother’s age at death	2.7	3.4	8.0	2.8	-1.2	2.0	0.3
Financial situation satisfaction	0.7	0.8	1.8	0.1	-0.7	1.0	1.3
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.6	-1.1	-2.4	-0.9	-0.0
Commuting to job workplace: Public transport	1.0	1.2	1.8	-1.3	-1.3	-1.0	-0.3
Eye problems/disorders: Glaucoma	0.6	0.7	2.0	-0.2	0.8	-0.3	1.4
Medication: Blood pressure	0.2	0.4	0.6	0.7	-0.8	0.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.7	-0.8	0.4	-0.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.9	0.2	-0.2	-0.0	-0.9
High cholesterol (Self-reported)	0.1	0.1	0.4	-0.2	-0.2	-0.6	0.1
Medication: Bendroflumethiazide	1.0	1.5	4.1	0.7	-1.2	0.3	-2.0
Medication: Paracetamol	1.4	2.2	3.7	-1.9	-1.1	-1.9	-0.5
Medication: Lisinopril	0.4	0.5	1.1	-1.1	0.0	-0.4	0.8
Medication: Atorvastatin	0.6	0.7	1.6	-1.3	0.1	-1.1	-0.2
Illnesses of father: High blood pressure	2.9	3.5	10.1	-3.2	0.1	-1.5	1.3
Alcohol drinker status: Never	0.4	0.5	1.0	0.0	-1.0	0.5	0.8
Ever smoked	0.5	1.0	3.0	0.4	1.7	0.7	0.5
Basal metabolic rate	0.9	5.0	11.1	-1.0	0.0	-2.8	-3.3
Leg fat percentage (left)	1.5	5.3	17.3	-0.0	-1.6	-1.1	-4.2
Arm fat-free mass (left)	0.7	3.5	7.4	-1.0	0.1	-2.4	-2.7
Number of operations (self-reported)	0.6	0.8	2.7	0.3	0.5	-0.6	-1.6
Average weekly beer plus cider intake	0.0	0.1	0.1	0.3	-0.0	-0.2	0.3
Irritability	0.2	0.3	0.8	0.5	0.9	-0.4	0.0
Risk taking	0.2	0.3	0.6	-0.8	0.4	0.2	0.6
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.1	1.5	0.1	0.3	-0.1
Fractured/broken bones in last 5 years	0.2	0.3	0.7	-0.8	0.0	-0.6	-0.0
Age started oral contraceptive pill	0.3	0.4	0.8	-0.5	0.7	-0.1	-0.9
Diastolic blood pressure, automated reading	0.8	2.4	6.6	-0.4	-0.8	-1.4	-2.6
Ever depressed for a whole week	0.5	0.6	1.2	-1.1	0.8	0.7	-0.2
Unable to work because of sickness or disability	1.4	1.8	4.3	1.5	-0.7	-0.6	-2.1
Commuting to job workplace: Cycle	0.6	0.8	1.1	0.5	-0.9	1.0	1.0
Myopia	1.3	1.8	4.3	1.2	0.6	2.1	1.2
Vascular/heart problems diagnosed by doctor	0.5	1.5	3.4	-0.3	0.7	-1.4	1.9
Cholesterol lowering medication	0.9	1.3	2.7	1.6	-1.1	1.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.1	-1.8	-0.7	-1.7	-0.4
Pain experienced in last month	0.8	1.4	2.9	-0.5	0.5	-1.4	1.7
Supplements: Calcium	0.4	0.5	0.8	0.5	-0.1	-0.9	-0.9
Basal cell carcinoma (self-reported)	1.6	1.9	4.0	-1.8	-0.4	-2.0	0.4
Heart attack/myocardial infarction (self-reported)	4.3	5.5	10.2	3.2	1.0	3.0	-1.3
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.3	0.2	1.5	0.9	2.1
Heart disease (siblings)	0.6	0.7	2.5	0.5	1.6	0.5	-0.1
Alcohol drinker status: Previous	1.1	1.2	2.8	-0.4	-0.6	1.2	1.7
Pack years of smoking	0.2	0.3	0.9	0.2	0.9	-0.7	-0.1
Impedance of whole body	0.3	1.8	5.0	0.1	1.4	0.5	2.2
Leg fat mass (left)	1.7	6.6	22.0	-0.2	-0.9	-1.9	-4.7
Arm predicted mass (left)	0.7	3.6	8.2	-1.0	-0.0	-2.3	-2.9