TWAS hub - RASAL2-AS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.114	0.0450	2.9e-05	0.041	NA	0.020	NA	0.022	2.7e-04	NA	8.9e-03	NA	6.3e-03
2	GTEx	Artery Aorta	0.114	0.0560	6.5e-03	0.098	NA	0.020	NA	0.076	4.8e-06	NA	2.5e-02	NA	5.6e-05
3	GTEx	Colon Transverse	0.122	0.0590	8.1e-03	0.034	NA	0.086	NA	0.062	9.6e-03	NA	6.8e-05	NA	6.5e-04
4	GTEx	Lung	0.136	0.0458	6.8e-05	0.012	NA	0.035	NA	0.050	4.0e-02	NA	9.6e-04	NA	1.1e-04
5	GTEx	Nerve Tibial	0.142	0.0421	1.4e-06	0.117	NA	0.072	NA	0.083	1.2e-08	NA	8.8e-06	NA	1.8e-06
6	GTEx	Skin Sun Exposed Lower leg	0.063	0.0330	6.5e-03	0.003	NA	0.015	NA	0.004	1.8e-01	NA	1.8e-02	NA	1.5e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Comparative body size at age 10	9.8	26.9	116.6	-0.7	-1.0	-1.4	10.8	1.2	6.3
Medication: Atorvastatin	6.0	7.4	12.2	3.5	2.7	2.8	1.1	2.1	3.4
Health satisfaction	5.7	7.5	10.2	3.2	2.8	1.2	2.7	3.2	2.7
Arm fat mass (left)	5.2	21.2	68.5	1.9	1.5	0.5	8.3	3.3	6.5
Arm fat mass (right)	5.0	20.7	66.7	1.9	1.4	0.3	8.2	3.2	6.4
Arm fat percentage (right)	4.9	19.4	59.9	2.4	1.9	1.1	7.7	3.4	5.9
Whole body fat mass	4.7	19.7	59.6	2.0	1.6	0.7	7.7	3.1	6.5
Weight	4.5	22.1	69.7	1.7	0.9	-0.1	8.3	2.9	7.1
Arm fat percentage (left)	4.5	18.1	56.0	2.0	1.9	1.3	7.5	3.3	5.7
Ever had hysterectomy (womb removed)	4.4	5.0	6.8	-2.5	-2.6	0.6	-2.0	-2.5	-2.5
Hip circumference	4.4	18.9	63.0	1.6	1.2	0.5	7.9	3.1	6.0
Leg fat mass (right)	4.4	17.0	52.7	1.8	1.4	0.8	7.3	2.9	6.0
Leg fat mass (left)	4.3	16.8	51.4	1.7	1.1	0.8	7.2	2.7	6.1
Waist circumference	4.2	15.4	49.7	1.9	1.7	0.6	7.0	2.9	5.2
Financial situation satisfaction	4.2	5.2	8.1	2.9	2.5	1.6	0.8	2.6	2.7
Body mass index (BMI)	4.1	17.6	60.8	0.9	0.6	0.3	7.8	2.4	6.2
Trunk fat mass	4.1	17.5	53.3	1.9	1.5	0.7	7.3	3.1	6.0
Medication: Seretide 50 evohaler	3.9	4.5	10.3	1.7	2.0	1.2	2.3	3.2	1.9
BMI	3.8	22.0	80.5	-0.0	-0.5	-0.9	9.0	1.6	6.9
Body fat percentage	3.7	14.6	44.2	2.0	1.8	1.5	6.7	2.9	5.1
Townsend deprivation index at recruitment	3.6	5.0	10.2	2.2	1.9	1.3	3.2	2.6	1.8
Leg fat-free mass (left)	3.5	18.7	54.2	0.9	0.2	-1.5	7.4	2.5	7.0
Leg predicted mass (left)	3.5	18.5	54.0	0.8	0.1	-1.5	7.3	2.5	6.9
Father’s age at death	3.4	4.5	8.4	-2.0	-1.9	-0.9	-2.9	-2.0	-2.5
Trunk fat percentage	3.3	13.3	39.9	1.8	1.7	1.3	6.3	2.9	4.9
Medication for cholesterol, blood pressure or diabetes	3.3	5.4	9.4	-2.1	-2.4	-1.1	-3.0	-1.6	-3.1
Depression (self-reported)	3.2	3.9	11.9	-1.1	-1.3	-1.2	-2.0	-1.7	-3.4
Leg fat-free mass (right)	3.2	16.9	49.6	0.4	-0.3	-1.7	7.0	1.9	6.7
Leg predicted mass (right)	3.2	17.0	49.6	0.4	-0.4	-1.7	7.0	1.9	6.8
Qualifications: A levels/AS levels or equivalent	3.1	6.8	10.6	-3.2	-2.7	-2.6	-1.3	-2.0	-3.3
Medication: Ibuprofen (e.g. Nurofen)	3.1	3.9	6.7	2.3	2.6	2.4	0.5	2.2	0.5
Basal metabolic rate	3.1	17.4	51.1	1.0	-0.0	-1.4	7.2	2.3	6.7
Financial difficulties in last 2 years	3.0	4.0	6.3	2.5	1.8	0.5	1.7	2.5	2.2
Qualifications: O levels/GCSEs or equivalent	3.0	4.7	13.2	-2.1	-2.0	-0.9	-1.7	-1.8	-3.6
Friendships satisfaction	3.0	3.7	6.9	2.3	2.6	1.5	1.0	2.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.0	3.6	8.7	2.7	1.6	0.8	1.5	2.9	-0.2
Qualifications: nursing, teaching	2.8	4.4	8.8	-1.8	-1.3	-3.0	-1.5	-1.8	-2.7
Past tobacco smoking	2.7	5.0	7.4	-2.4	-2.3	-1.0	-2.5	-2.7	-2.0
Length of working week for main job	2.7	3.0	4.1	-1.7	-1.9	-2.0	-1.7	-2.0	-0.7
Leg fat percentage (right)	2.7	9.8	31.9	1.4	1.4	1.3	5.7	2.3	4.0
Medication: Blood pressure	2.7	4.7	11.9	1.9	1.9	0.8	3.4	1.4	2.6
Whole body fat-free mass	2.7	15.3	42.5	0.6	-0.3	-1.8	6.5	2.0	6.5
Whole body water mass	2.7	15.1	42.5	0.6	-0.4	-1.8	6.5	1.9	6.4
Leg fat percentage (left)	2.7	9.8	31.7	1.3	1.0	1.4	5.6	2.0	4.3
Arm fat-free mass (left)	2.7	13.9	40.6	0.5	-0.4	-1.6	6.4	1.8	6.0
Arm predicted mass (left)	2.7	13.6	40.2	0.2	-0.6	-1.5	6.3	1.6	6.0
Mouth/teeth dental problems	2.6	4.0	7.2	-2.7	-2.4	-1.1	-0.9	-2.1	-2.1
Breast cancer (self-reported)	2.5	3.0	6.6	-1.9	-2.6	0.4	-2.3	-1.5	0.3
Alcohol drinker status: Never	2.5	3.0	5.1	-2.2	-2.2	-0.7	-1.8	-2.0	-0.7
Basal cell carcinoma (self-reported)	2.5	2.9	10.8	1.5	0.1	1.2	1.4	1.0	3.3
Alcohol usually taken with meals	2.4	3.9	8.1	-2.4	-1.5	-0.7	-1.8	-1.8	-2.9
Mouth/teeth dental problems: Loose teeth	2.4	2.9	4.5	2.0	1.6	1.4	1.1	1.8	2.1
Medication: Omeprazole	2.4	2.9	8.4	-1.2	-1.8	-0.6	-1.4	-2.9	-1.3
Ever smoked	2.4	4.2	6.6	2.1	2.4	0.5	2.5	2.6	1.5
Medication: Omeprazole (e.g. Zanprol)	2.4	3.0	8.9	-1.5	-2.1	-0.0	-1.3	-3.0	-0.9
Frequency of depressed mood in last 2 weeks	2.3	3.2	7.0	1.9	2.3	2.6	1.1	1.3	0.7
Age when periods started (menarche)	2.3	5.5	18.8	0.4	0.4	1.9	-4.3	-0.8	-3.1
Illnesses of siblings	2.3	3.2	10.0	-2.0	-1.5	-0.8	-0.4	-1.6	-3.2
Frequency of tiredness / lethargy in last 2 weeks	2.3	3.7	6.6	2.6	2.5	1.8	0.7	2.4	0.0
Prospective memory result	2.3	2.8	5.3	2.2	1.3	0.3	1.5	2.3	1.7
Arm predicted mass (right)	2.3	11.9	33.5	0.2	-0.5	-1.5	5.8	1.7	5.7
Chronotype (morning person)	2.2	5.2	6.3	2.5	2.5	-0.6	2.5	2.4	2.5
Noisy workplace	2.2	2.7	4.3	1.9	1.4	2.1	1.9	1.0	1.4
Arm fat-free mass (right)	2.2	11.3	31.2	0.0	-0.6	-1.8	5.6	1.5	5.5
Age at first live birth	2.2	3.9	8.3	-2.1	-1.4	-2.2	-2.9	-1.8	-0.9
Chest pain or discomfort	2.2	3.1	6.6	2.4	1.6	0.6	2.6	1.9	-0.5
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	9.9	-0.9	-1.9	-0.1	-0.5	-1.2	-3.1
Impedance of leg (right)	2.1	10.0	23.9	2.1	2.4	2.6	-4.9	0.6	-4.3
Impedance of leg (left)	2.1	10.2	28.5	1.8	1.8	2.6	-5.3	-0.1	-4.4
Nervous feelings	2.1	4.0	7.2	2.5	2.7	1.7	1.2	2.4	-0.8
Ever unenthusiastic/disinterested for a whole week	2.1	2.6	5.2	1.5	1.6	1.1	1.4	2.3	1.6
Trunk fat-free mass	2.1	11.8	31.9	0.5	-0.4	-1.9	5.6	1.7	5.7
Trunk predicted mass	2.1	12.1	32.8	0.6	-0.3	-2.0	5.7	1.8	5.7
High blood pressure (siblings)	2.1	3.0	7.1	1.9	1.9	0.9	0.8	1.4	2.7
Headache pain in last month	2.0	3.4	7.3	2.1	2.7	1.6	0.6	2.3	-0.7
Shortness of breath walking on level ground	2.0	2.4	4.6	1.5	1.1	-0.8	2.1	2.0	1.1
Loneliness, isolation	2.0	2.7	6.1	2.0	1.8	-0.2	1.2	1.2	2.5
Ever depressed for a whole week	2.0	2.5	3.5	1.8	1.5	1.3	1.2	1.7	1.9
Medication: Cholesterol lowering	1.9	2.9	5.2	2.1	2.3	1.1	1.4	1.4	1.6
Emphysema/chronic bronchitis	1.9	2.1	4.4	1.6	1.6	0.3	0.8	2.1	1.6
Average weekly beer plus cider intake	1.9	2.7	4.8	1.7	2.2	1.4	0.9	1.4	2.0
Vascular/heart problems diagnosed by doctor	1.9	5.3	9.6	-2.2	-2.1	-1.1	-2.9	-1.8	-3.1
Schizophrenia (2014)	1.8	4.0	9.4	-2.3	-1.8	0.6	-1.4	-1.9	-3.1
High blood pressure	1.8	4.9	10.0	1.9	1.7	1.8	2.8	1.4	3.2
Miserableness	1.8	3.2	5.6	1.4	1.4	1.9	2.1	1.3	2.4
Heart disease (siblings)	1.8	2.2	3.9	2.0	1.5	1.3	0.8	1.5	1.6
Impedance of whole body	1.8	9.1	21.5	1.6	2.2	2.4	-4.6	0.4	-4.4
Schizophrenia (2018)	1.7	3.5	4.6	-2.1	-1.6	1.0	-2.1	-2.1	-2.1
Crohns Disease (2012)	1.6	2.6	4.9	-2.2	-1.7	0.9	-0.6	-1.5	-2.1
LDL Cholesterol	1.6	2.5	5.9	2.4	2.1	1.5	1.2	0.9	0.0
Happiness	1.6	1.9	3.6	1.7	1.6	1.4	0.6	1.9	-0.4
Wheeze or whistling in the chest in last year	1.6	2.9	5.9	2.0	1.6	2.4	1.7	1.5	-0.1
Smoking status: Previous	1.6	2.4	3.8	2.0	1.4	0.9	1.8	1.8	1.2
Medication: Aspirin	1.6	2.1	4.2	1.4	1.2	1.2	1.9	0.6	2.0
Schizophrenia vs Biploar Disorder	1.5	2.0	5.6	-1.8	-0.7	0.3	-1.2	-1.1	-2.4
Smoking Status	1.5	3.5	6.5	2.3	1.4	0.1	2.3	2.6	1.5
Stomach or abdominal pain in last month	1.5	1.9	5.6	0.9	1.1	0.9	1.1	1.4	-2.4
Medication: Ramipril	1.5	1.9	3.3	1.8	1.3	0.4	1.5	1.4	1.5
Medication: Ibuprofen	1.5	1.7	2.8	1.6	1.6	1.7	-0.0	1.5	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	2.9	1.7	1.3	0.3	1.7	1.6	0.8
Illness, injury, bereavement, stress in last 2 years	1.5	1.8	3.6	-1.9	-1.0	0.1	-1.4	-1.9	-0.9
Hypertension (Self-reported)	1.5	4.2	8.5	1.7	1.4	2.1	2.5	1.1	2.9
Illnesses of siblings: Diabetes	1.5	1.8	2.7	1.5	1.1	1.6	0.6	1.4	1.6
Medication: Metformin	1.4	2.0	7.4	-0.3	-0.0	-0.1	2.7	-0.2	2.2
High blood pressure (mother)	1.4	2.0	5.6	0.8	1.4	1.4	2.4	1.3	0.1
Impedance of arm (right)	1.4	6.4	9.3	2.9	3.0	2.5	-2.2	1.5	-2.7
Impedance of arm (left)	1.4	6.6	11.2	2.0	2.6	2.7	-3.1	0.9	-3.4
Number of full sisters	1.4	1.8	4.6	1.5	1.1	-0.5	1.5	2.1	-0.2
Illnesses of father: Heart disease	1.4	1.9	4.2	1.2	2.1	0.5	1.3	1.8	-0.8
Osteoporosis (self-reported)	1.4	1.8	2.6	-1.6	-1.2	0.4	-1.3	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	5.0	-1.3	-1.3	-0.8	-2.2	-2.0	-2.0
Bipolar Disorder or Schizophrenia	1.3	3.3	5.0	-2.2	-1.9	0.5	-1.4	-2.2	-2.0
Body Mass Index (BMI) (2010)	1.3	1.8	9.6	-0.3	-0.5	-0.5	3.1	0.0	0.8
Neuroticism (2016)	1.3	1.8	4.5	1.5	1.4	2.1	0.4	0.9	1.1
Rheumatoid Arthritis	1.3	1.7	4.2	1.2	2.0	1.4	0.6	0.8	1.4
Angina	1.3	1.7	3.6	1.6	0.8	-1.4	1.9	1.4	-0.2
Qualifications: CSEs or equivalent	1.3	1.7	5.2	0.8	1.1	1.5	0.6	0.7	2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	5.2	1.8	1.5	1.0	2.0	1.4	2.3
Asthma	1.3	2.5	5.0	-2.2	-1.9	-1.8	-0.1	-1.3	-1.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	6.7	0.6	0.5	1.5	0.8	0.1	2.6
Medication: Amlodipine	1.3	1.8	4.3	1.3	0.9	0.2	2.1	1.4	1.4
Angina (self-reported)	1.3	1.7	3.2	1.7	0.8	-1.3	1.8	1.4	-0.1
Verbal and Numeric Reasoning (VNR)	1.2	2.8	8.1	-1.7	-0.9	-2.9	-1.7	-1.4	-0.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.1	1.8	1.6	1.2	-0.0	0.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.2	1.7	1.5	1.8	-0.2	0.9	-0.5
Comparative height size at age 10	1.2	6.4	18.8	1.5	0.6	-1.1	4.3	1.1	3.8
Overall health rating	1.2	2.7	4.2	1.6	1.6	1.3	2.0	1.7	1.4
Age at last live birth	1.2	1.7	6.5	-0.8	-0.2	-1.5	-2.5	-0.5	-0.7
Depression (Nagel 2018)	1.1	1.6	4.0	1.5	1.6	2.0	0.1	0.9	0.1
Prostate Cancer	1.1	1.6	4.6	1.4	0.6	1.3	2.1	1.0	-0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	1.9	1.4	1.2	0.7	1.3	1.1	0.4
Pulse wave reflection index	1.1	1.3	2.7	-1.2	-1.1	-1.3	-0.9	-1.6	-0.4
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.0	1.2	1.6	0.2	0.4	1.7	-0.9
Number of children fathered	1.1	1.3	3.4	-1.1	-1.1	-1.8	-0.7	-0.8	-0.9
Medication: Aspirin	1.1	1.5	3.4	1.1	1.1	0.7	1.6	0.4	1.9
Asthma (self-reported)	1.1	2.2	4.3	-2.1	-1.8	-1.5	-0.3	-1.2	-1.2
Medication: Lisinopril	1.1	1.4	4.5	-0.4	-0.1	1.9	2.1	0.1	0.4
Age at First Birth	1.0	1.5	5.5	-0.9	-0.1	-2.3	-1.1	-0.1	-1.1
HDL Cholesterol	1.0	1.7	4.5	-0.8	-0.8	-1.2	-1.7	-0.2	-2.1
Cardiovascular Disease	1.0	3.3	6.6	1.3	1.9	1.0	2.3	1.4	2.6
Diabetes (mother)	1.0	1.3	4.1	-0.5	-0.3	-1.4	1.1	-0.5	2.0
Average weekly fortified wine intake	1.0	1.2	4.3	-0.5	-1.1	0.3	-2.1	-1.1	-0.3
Serious illness, injury or assault to yourself	1.0	1.3	2.1	-0.9	-1.2	-1.0	-0.7	-1.4	-1.3
Medication: Atenolol	1.0	1.2	1.7	1.0	1.1	0.8	1.3	0.9	1.3
Diabetes (self-reported)	1.0	1.5	3.5	-0.4	0.4	1.7	1.4	-0.7	1.9
Tense / ‘highly strung’	1.0	1.6	3.6	1.4	1.5	1.9	-0.6	0.2	1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.1	0.7	0.8	0.7	1.8	1.4	1.1
Mean time to correctly identify matches	1.0	1.8	4.2	-1.3	-1.4	-1.0	-2.1	-1.4	-0.6
Heart disease (mother)	1.0	1.2	3.2	-0.3	-0.1	-1.8	0.6	-0.8	-1.7
Alcohol intake frequency.	1.0	2.3	5.5	-2.0	-2.3	-0.9	0.4	-1.8	0.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.2	2.1	0.9	-0.7	0.1	0.3	1.3
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	3.7	0.9	1.5	1.0	-1.9	0.4	1.1
Mother’s age at death	1.0	1.3	4.0	-0.9	-0.6	-0.6	-1.5	-0.3	-2.0
Commuting to job workplace: Cycle	1.0	1.2	2.6	-1.3	-1.6	-1.6	-0.2	-0.8	-0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.1	3.7	0.1	0.5	1.2	1.9	0.9	-0.3
Blood White Count	0.9	6.8	11.3	1.8	3.1	2.9	2.4	3.4	1.6
Lung FVC	0.9	4.4	11.1	-1.0	-1.4	-2.3	-3.3	-2.1	-1.6
Multivitamins +/- minerals	0.9	1.2	1.9	1.2	1.4	0.7	-0.1	1.1	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	3.4	1.8	1.4	1.4	-0.4	0.7	-0.4
Pain all over the body in last month	0.9	1.0	4.0	-0.5	-0.5	-2.0	-0.6	-0.3	-0.9
Birth weight of first child	0.9	1.7	3.8	-1.9	-1.9	-0.2	0.1	-1.5	-0.6
Migraine (self-reported)	0.9	1.2	3.6	-0.0	-0.4	1.1	-1.4	0.3	-1.9
Medication: Allopurinol	0.9	1.2	4.0	-0.0	-1.1	2.0	0.2	-0.4	1.3
Supplements: Vitamin C	0.9	1.0	1.4	1.0	1.1	0.5	1.2	1.1	1.1
Long-standing illness, disability or infirmity	0.9	1.3	3.2	-1.4	-1.8	-0.9	0.9	-1.1	-0.4
Diabetes diagnosed by doctor	0.9	1.5	3.6	-0.6	0.1	1.6	1.9	-0.9	1.4
Alzheimer’s Disease (in mother)	0.8	0.9	1.3	1.2	0.8	1.1	0.6	1.1	0.9
Blood Eosinophil Count	0.8	5.9	14.1	-3.8	-2.9	-1.8	-1.3	-2.2	-1.7
Current tobacco smoking	0.8	1.3	3.8	1.2	1.2	0.0	1.1	1.9	0.2
Maternal smoking around birth	0.8	1.1	2.7	0.4	0.6	-0.3	1.6	0.9	1.6
Chronic bronchitis/emphysema (father)	0.8	0.9	3.4	-0.2	-0.2	-0.3	-1.4	0.1	-1.8
Alcohol intake versus 10 years previously	0.8	1.3	2.7	-0.7	-1.6	-1.0	-0.9	-1.4	0.8
Number of live births	0.8	1.1	2.9	0.5	0.9	0.6	1.5	1.7	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.3	1.2	1.0	-0.4	-0.2	0.7	1.5
Medication: Lansoprazole	0.8	0.9	2.6	1.1	0.9	-0.3	1.6	0.9	-0.1
Eye problems/disorders: Cataract	0.8	0.9	2.6	-0.4	0.5	1.6	0.8	-0.2	1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	1.7	0.6	0.7	1.3	0.7	0.9	1.2
Fasting Glucose	0.7	0.9	3.2	-0.3	-0.1	-1.8	0.2	-0.8	1.1
Respiratory disease	0.7	1.6	3.1	-1.4	-1.1	-1.8	0.1	-0.2	-1.8
Lung FEV1/FVC ratio	0.7	3.3	8.5	-2.1	-2.9	-1.0	-0.7	-2.1	-1.1
Relative age of first facial hair	0.7	1.4	4.1	0.4	1.4	-0.1	-2.0	0.8	-1.2
Severe depression (siblings)	0.7	0.8	3.0	0.6	0.5	0.5	1.7	0.8	0.6
Relative age voice broke	0.7	1.1	2.2	1.4	1.5	0.2	-0.7	1.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.1	0.8	0.8	-1.1	2.0	0.9	1.7
Pulse wave Arterial Stiffness index	0.7	0.8	1.9	-1.0	-1.1	-0.4	-0.6	-1.4	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	4.7	0.7	0.1	2.2	-0.3	-0.1	-1.1
Pulse wave peak to peak time	0.7	0.8	2.0	1.0	1.1	0.3	0.6	1.4	0.4
Pulse rate, automated reading	0.7	2.2	3.6	-1.7	-1.9	-0.9	-1.2	-1.0	-1.8
Leg pain on walking	0.7	0.9	1.8	0.5	0.2	1.0	1.3	0.8	1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	1.2	1.3	0.1	-0.7	0.9	-0.3
Average weekly red wine intake	0.7	1.0	3.5	-0.8	-0.9	0.4	-1.9	-0.9	-0.5
Irritability	0.7	1.1	2.3	1.2	1.5	0.7	0.6	1.3	0.6
Risk taking	0.7	1.1	3.0	1.0	0.5	0.9	1.7	0.5	1.1
Alcohol drinker status: Previous	0.7	0.8	2.0	0.1	0.3	1.2	1.4	0.3	1.0
Intelligence (Savage-Jansen 2018)	0.6	1.8	6.5	-1.1	-0.1	-2.5	-1.2	-1.3	0.5
Coronary Artery Disease (CAD)	0.6	0.8	1.7	-1.3	-0.2	1.1	0.2	-0.6	-1.2
Lupus	0.6	1.0	2.4	1.1	-0.3	-0.1	1.5	-0.0	1.6
Allergy or Eczema	0.6	1.5	5.0	-1.4	-0.4	-0.3	-0.8	-1.2	-2.2
Type 2 Diabetes (T2D) (2018)	0.6	1.0	2.0	-1.3	-0.9	0.3	1.1	-1.4	0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	3.4	0.2	-0.0	0.2	1.8	-0.4	0.3
Medication for hormone replacement therapy	0.6	0.7	1.6	-0.1	-0.3	-0.1	-1.3	-0.9	-1.2
Supplements: Zinc	0.6	0.6	1.4	0.3	0.7	0.3	0.9	1.0	-1.2
Qualifications: None of the above	0.6	1.4	6.1	0.9	0.0	2.5	1.0	0.4	0.4
Medication: Simvastatin	0.6	0.8	3.0	1.1	0.6	-0.5	1.7	-0.2	0.3
Neuroticism score	0.6	1.2	2.2	1.5	1.3	1.2	0.5	1.0	0.7
Time employed in main current job	0.6	0.7	1.2	0.7	0.1	0.9	1.1	0.8	1.0
Falls in the last year	0.6	0.7	2.7	0.0	0.8	0.8	-0.8	-0.1	-1.6
Hair/balding pattern: Pattern 3	0.6	0.8	2.8	-0.6	-0.6	-0.8	-0.8	-0.5	-1.7
Mouth/teeth dental problems: Dentures	0.6	1.1	1.7	1.2	1.0	-1.3	0.6	1.1	0.8
Qualifications: College or University degree	0.6	2.0	6.0	-1.0	-1.2	-2.5	-0.9	-1.4	-1.0
Eye problems/disorders: None of the above	0.6	0.7	2.2	0.1	-0.6	-0.5	-1.5	0.1	-1.3
Family relationship satisfaction	0.6	0.8	1.5	0.6	1.0	0.9	-0.5	1.2	0.8
Smoking status: Current	0.6	0.9	2.8	0.9	1.0	0.1	0.8	1.7	0.3
Number of self-reported non-cancer illnesses	0.6	1.0	3.1	0.8	1.0	1.1	1.8	0.3	-0.1
Tinnitus: Yes, now most or all of the time	0.6	0.8	2.9	-0.1	0.2	-0.5	1.2	0.1	1.7
Commuting to job workplace: Public transport	0.6	0.7	1.6	-1.3	-1.1	-0.8	-0.1	-0.8	0.1
Worry (Nagel 2018)	0.5	1.1	3.2	1.3	1.2	1.8	-0.6	0.4	-0.3
Breast Cancer	0.5	1.2	3.1	-0.1	-0.0	-1.6	1.3	0.0	1.8
HbA1C	0.5	0.6	1.1	1.1	1.0	0.6	0.0	0.3	1.0
Ulcerative Colitis	0.5	0.8	2.9	-0.3	-0.5	1.7	-1.1	-0.1	0.2
Heel T-Score	0.5	3.9	9.5	1.3	2.1	-0.3	3.1	1.6	2.2
Neuroticism	0.5	1.1	2.4	1.3	1.1	1.6	0.2	1.1	0.3
Number of treatments/medications taken	0.5	0.9	4.5	0.0	0.0	0.7	2.1	-0.2	0.6
Diabetes (father)	0.5	0.6	1.3	-1.1	-0.6	-0.9	0.8	-0.5	0.4
Fed-up feelings	0.5	1.0	2.0	1.2	1.4	0.8	0.5	1.0	0.7
Supplements: Glucosamine	0.5	0.7	1.3	1.0	0.6	0.5	0.8	0.8	1.2
Number of incorrect matches in round	0.5	0.8	2.5	-0.4	-0.8	1.0	0.7	-0.4	1.6
Illnesses of mother	0.5	0.6	1.1	-0.7	-0.9	-0.6	-1.0	-0.8	0.5
Exposure to tobacco smoke at home	0.5	0.6	1.5	0.5	1.0	0.2	1.2	0.9	-0.0
Gout (self-reported)	0.5	0.7	2.5	0.1	-0.8	-0.1	0.9	0.0	1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.2	0.6	1.0	0.3	1.5	0.6	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.1	0.3	-0.3	-1.0	1.3	0.4	1.8
Commuting to job workplace: Walk	0.5	0.5	1.4	-0.7	-0.8	-0.2	-0.5	-1.2	0.4
Supplements: Fish oil (including cod liver oil)	0.5	0.6	1.2	-1.0	-0.9	-0.7	-0.2	-1.1	0.5
Medication: Bendroflumethiazide	0.5	0.8	4.3	0.5	-0.0	0.4	-0.1	0.0	2.1
Bipolar Disorder (2018)	0.4	0.6	1.2	-1.0	-1.1	-0.5	0.3	-0.9	-0.5
Neuroticism (Nagel 2018)	0.4	0.9	3.1	1.1	0.8	1.8	-0.1	0.4	0.5
Alzheimer’s Disease (in father)	0.4	0.4	2.0	0.1	-0.3	-1.4	-0.0	0.6	0.3
Major Depression (MDD)	0.4	0.5	1.1	-1.0	-0.5	0.4	0.8	-0.2	-0.8
Ovarian Cancer	0.4	0.6	2.6	-0.1	0.6	-0.3	0.1	-0.6	1.6
Bipolar Disorder (2011)	0.4	0.4	1.1	-1.1	-0.1	0.7	0.6	-0.2	-0.5
Mean Putamen Volume	0.4	0.4	1.3	0.5	0.4	0.8	0.1	1.1	-0.3
Sensitivity / hurt feelings	0.4	0.6	3.1	0.2	0.1	1.8	0.2	0.5	-0.5
Systolic blood pressure, automated reading	0.4	1.2	2.4	-1.1	-1.1	-1.0	0.3	-1.6	-1.1
Taking other prescription medications	0.4	0.5	1.1	-0.7	-0.9	1.0	0.6	-0.7	0.1
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	-1.1	-0.3	-0.7	0.4	0.0	-1.0
Sitting height	0.4	2.6	5.2	-0.0	-0.5	-2.2	2.1	0.9	2.3
Allergy	0.4	1.0	2.0	1.4	0.8	0.9	0.1	0.9	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	2.3	0.3	0.7	-0.1	0.2	0.5	-1.5
Ever highly irritable/argumentative for 2 days	0.4	0.5	2.7	0.0	0.0	0.1	-1.6	-0.1	0.3
High cholesterol (Self-reported)	0.4	0.6	2.2	1.1	1.5	0.3	0.3	0.5	-0.0
Number of operations (self-reported)	0.4	0.7	1.5	1.2	0.7	0.3	1.1	0.8	0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.2	-0.6	-0.2	1.1	-0.8	0.1	-0.7
Supplements: Calcium	0.4	0.5	0.9	-0.9	-0.7	0.1	-0.3	-0.9	-0.8
Depressed Affect (Nagel 2018)	0.3	0.5	1.6	-0.0	0.2	1.2	0.3	-0.1	1.3
Reaction Time	0.3	0.5	2.0	-0.5	-0.7	-0.4	-1.4	-0.4	-0.2
Waist Hip Ratio (WHR)	0.3	1.3	2.8	1.1	1.7	0.4	-0.6	1.2	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.6	-1.0	-0.0	-0.5	-0.1	-0.7	-1.3
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.6	0.7	1.0	0.7	0.3	0.2
Had other major operations	0.3	0.4	1.0	-0.2	-0.7	-0.8	-1.0	-0.2	-0.5
Fluid intelligence score	0.3	0.6	2.7	-0.3	0.6	-1.6	-0.6	-0.0	0.3
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	1.9	-0.0	-0.9	-1.4	-1.3	-0.5	-0.8
Pulse rate	0.3	0.4	1.0	-0.8	-1.0	0.2	-0.9	-0.4	0.1
Standing height	0.3	3.2	9.0	1.8	0.7	-0.8	1.9	1.5	3.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.1	-0.0	-0.1	-1.1	1.5	0.4	-0.4
Medication for pain relief, constipation, heartburn	0.3	0.5	2.6	-0.3	-0.2	-1.6	-0.3	0.2	0.1
Suffer from ‘nerves’	0.3	0.4	1.0	0.3	0.6	-1.0	-0.4	-0.5	-0.9
Mood swings	0.3	0.6	2.2	-0.2	0.4	1.5	0.5	-0.4	1.0
Ever had bowel cancer screening	0.3	0.4	0.9	-0.3	-0.6	-1.0	-0.1	-0.9	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.1	0.3	-0.2	-0.2	-0.5	1.0	0.7
Back pain experienced in last month	0.3	0.4	1.8	0.1	-0.6	-0.4	-0.4	-0.3	-1.3
Medication: Gliclazide	0.3	0.3	1.1	-0.6	0.0	-0.6	0.1	-0.4	1.0
Illnesses of father: None of the above (group 1)	0.3	0.4	1.4	-0.4	-0.7	1.2	0.3	-0.3	-0.4
Guilty feelings	0.3	0.5	1.1	0.7	0.2	0.7	0.9	0.1	1.1
Hearing aid user	0.3	0.3	0.8	-0.2	-0.9	0.5	-0.1	-0.3	-0.8
Myopia	0.3	0.4	0.8	0.6	0.6	0.7	-0.7	0.2	0.9
Pain experienced in last month	0.3	0.6	1.1	-0.9	-0.5	-1.1	-0.7	-0.7	0.5
Pack years of smoking	0.3	0.4	1.2	-0.5	-1.0	-0.1	0.4	-0.4	-1.1
Crohns Disease (2017)	0.2	0.5	2.4	-0.4	0.3	0.4	0.4	0.4	-1.5
Irritable Bowel Disease (IBD)	0.2	0.6	1.8	-0.5	-0.1	1.1	-0.3	0.3	-1.4
Ulcerative Colitis (UC)	0.2	0.3	1.3	-0.2	-0.3	1.1	-0.6	0.3	-0.5
Triglycerides	0.2	0.3	0.9	-0.2	-0.3	-0.4	0.4	-1.0	-0.6
Blood Red Count	0.2	2.1	5.1	-2.3	-1.8	-0.5	0.3	-1.9	-0.8
Hypothyroidism (self reported)	0.2	0.4	1.8	-0.6	-0.4	-0.3	1.3	-0.0	-0.5
Hand grip strength (left)	0.2	0.5	1.3	1.1	-0.4	-0.7	-0.8	0.3	0.3
Average weekly spirits intake	0.2	0.2	0.7	0.6	0.8	0.4	0.3	0.2	0.1
Pack years adult smoking proportion	0.2	0.2	0.8	0.0	-0.5	-0.0	0.9	0.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.4	0.2	0.4	0.6	0.7	-0.3	0.2
Medication: Levothyroxine sodium	0.2	0.4	1.9	0.0	0.4	-0.5	1.4	0.4	0.1
Hearing difficulty/problems with background noise	0.2	0.2	1.1	-0.3	-0.1	-0.4	0.3	-0.3	-1.0
Had menopause	0.2	0.3	1.0	-0.0	0.3	0.6	0.5	0.3	1.0
Forced vital capacity (FVC)	0.2	0.7	2.3	0.8	0.0	-1.5	-1.0	0.1	0.2
Heart attack	0.2	0.2	0.8	0.9	0.5	0.2	-0.3	0.4	0.2
Worrier / anxious feelings	0.2	0.3	1.1	0.1	-0.1	1.0	-0.8	-0.1	0.4
Lung cancer (father)	0.2	0.2	1.0	-0.1	-0.3	-1.0	-0.2	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.6	1.4	-0.2	-0.9	-0.6	-1.2	-0.8	-0.6
Peak expiratory flow (PEF)	0.2	0.4	0.8	0.9	-0.1	-0.8	0.7	0.7	-0.1
Blood clot in the leg (DVT)	0.2	0.2	0.7	-0.4	-0.5	0.3	-0.4	-0.1	0.8
Medication: Paracetamol	0.2	0.4	1.6	0.4	-0.7	0.3	-1.3	-0.3	0.2
Glaucoma (self-reported)	0.2	0.2	0.5	-0.7	0.3	0.0	-0.7	-0.5	-0.4
Exposure to tobacco smoke outside home	0.2	0.3	1.5	0.0	0.2	1.2	-0.4	0.5	0.0
Worry too long after embarrassment	0.2	0.3	1.3	0.8	0.2	-0.2	-1.1	0.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.9	-0.5	-0.0	0.1	-0.6	-0.0	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.6	0.7	0.7	-0.0	-0.3	-0.3	-0.6
Medication for cholesterol	0.2	0.3	0.7	-0.5	0.0	-0.9	-0.1	0.6	-0.6
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.8	0.1	1.0	-0.6	0.2	-0.1
Medication: Blood pressure	0.2	0.5	1.4	0.1	-0.4	1.0	0.5	-0.0	1.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.1	-0.7	0.3	0.1	-0.7	0.8
Medication: Paracetamol	0.2	0.3	0.9	-0.2	-0.9	0.2	-0.9	-0.4	0.3
Unable to work because of sickness or disability	0.2	0.2	0.4	0.5	0.6	-0.2	0.6	0.0	-0.6
Cholesterol lowering medication	0.2	0.3	0.5	0.5	-0.0	-0.3	0.6	-0.7	0.6
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	0.9	0.5	0.1	-0.2	0.4	0.3
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	1.0	-0.3	-0.3	-0.3	-0.2	-0.2	1.0
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	0.6	-0.2	0.2	0.5	0.5	0.2
Primary Biliary Cirrhosis	0.1	0.2	0.6	-0.3	-0.5	-0.0	0.2	-0.8	0.4
Blood Platelet Count	0.1	1.6	3.5	-0.4	1.5	1.9	-0.7	1.7	-0.6
Height	0.1	2.3	7.9	0.8	-0.7	-1.4	1.4	0.9	2.8
Hair Pigment	0.1	4.2	10.7	-1.8	-2.0	-3.3	-2.1	-1.7	-0.6
Tanning	0.1	1.6	4.3	-1.1	-1.1	-0.9	-1.4	-0.6	-2.1
Hearing difficulty/problems: Yes	0.1	0.1	0.4	0.3	0.2	0.0	-0.6	-0.3	-0.4
Vitamin and mineral supplements	0.1	0.2	0.5	-0.3	-0.7	-0.2	-0.3	-0.5	-0.4
Medication: Co-codamol	0.1	0.1	0.3	-0.6	0.3	0.4	0.2	0.1	0.3
Hand grip strength (right)	0.1	0.3	0.9	1.0	0.1	-0.5	-0.4	0.6	0.0
Breastfed as a baby	0.1	0.1	0.5	-0.0	-0.3	0.7	-0.4	-0.1	-0.3
Hair/balding pattern: Pattern 4	0.1	0.4	1.2	-0.2	0.3	0.8	0.3	0.3	1.1
Loud music exposure frequency	0.1	0.1	0.3	0.3	-0.0	-0.2	-0.5	0.2	-0.5
Birth weight	0.1	0.1	0.4	0.2	-0.2	-0.1	-0.3	0.6	-0.5
Forced vital capacity (FVC), Best measure	0.1	0.3	1.0	0.4	-0.2	-0.8	-1.0	-0.2	0.0
Number of full brothers	0.1	0.1	0.3	0.1	0.0	-0.3	0.1	-0.6	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.9	0.9	-0.2	-0.1	-0.1	0.2	0.2
Neck or shoulder pain in last month	0.1	0.1	0.2	0.4	-0.2	-0.2	-0.2	0.1	-0.4
Had major operations	0.1	0.1	0.3	-0.0	0.2	0.2	-0.6	-0.1	0.1
Knee pain experienced in last month	0.1	0.2	0.6	-0.1	-0.3	0.5	0.7	-0.4	0.4
Mineral and other dietary supplements	0.1	0.2	0.6	0.2	0.4	-0.2	-0.3	0.3	-0.8
Osteoarthritis (self-reported)	0.1	0.1	0.6	-0.0	0.5	0.7	0.2	0.1	-0.1
Wears glasses or contact lenses	0.1	0.1	0.3	0.0	-0.6	-0.4	-0.3	-0.1	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.6	0.3	0.0	-0.1	0.1	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.6	0.2	0.3	0.2	-0.3	0.3
Illnesses of father: High blood pressure	0.1	0.2	0.3	0.4	0.4	0.3	-0.6	-0.2	0.6
Diastolic blood pressure, automated reading	0.1	0.4	1.2	-0.3	-0.8	-0.8	0.1	-1.1	0.3
Systolic Blood Pressure	0.0	0.2	0.6	0.6	0.8	-0.3	0.1	-0.0	0.2
Age started oral contraceptive pill	0.0	0.0	0.1	-0.3	0.0	0.3	0.0	-0.3	0.1

Hub : Genes

RASAL2-AS1

Models

Trait associations