TWAS hub - RASD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0358	0.0123	3.1e-06	0.005	0.015	0.010	0.015	0.008	6.7e-03	6.3e-06	2.7e-04	9.5e-06	0.00082
2	TCGA	Lung Adenocarcinoma	0.0373	0.0199	1.4e-03	0.045	0.022	0.026	NA	0.030	5.7e-06	1.2e-03	4.5e-04	NA	0.00016
3	TCGA	Thyroid Carcinoma	0.0420	0.0220	2.4e-04	0.045	0.043	0.043	NA	0.038	2.9e-05	4.5e-05	4.7e-05	NA	0.00011

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Waist Hip Ratio (WHR)	17.6	79.1	112.4	-10.6	-5.9	-9.5
Average weekly spirits intake	6.9	8.6	12.0	-2.1	-3.0	-3.5
Health satisfaction	6.9	8.9	11.6	-2.2	-3.2	-3.4
Chronotype (morning person)	6.8	15.7	24.4	-0.6	-4.7	-4.9
Medication for cholesterol	6.6	10.1	13.7	3.7	3.0	2.7
Alzheimer’s Disease (in mother)	5.6	6.5	9.0	2.1	3.0	2.5
Birth weight of first child	5.3	9.6	21.1	4.6	1.3	2.5
Hip circumference	5.0	21.4	28.4	5.0	3.2	5.3
Average weekly champagne plus white wine intake	5.0	6.9	9.0	2.0	3.0	2.7
Medication: Gliclazide	4.7	5.3	6.2	-2.2	-2.5	-2.2
Coronary Artery Disease (CAD)	4.6	5.5	8.5	-2.9	-1.0	-2.7
Cholesterol lowering medication	4.6	6.8	15.1	-3.9	-1.3	-1.9
Triglycerides	4.5	7.4	10.1	-2.0	-2.9	-3.2
Diverticular disease/diverticulitis (self-reported)	4.4	5.3	9.3	-3.1	-1.7	-1.9
Ever depressed for a whole week	4.2	5.2	5.6	-2.2	-2.3	-2.4
Medication: Metformin	4.1	5.8	6.9	-2.1	-2.5	-2.6
Birth weight	3.9	8.4	11.2	2.7	2.6	3.4
Schizophrenia vs Biploar Disorder	3.8	4.9	7.3	-0.8	-2.7	-2.6
Eye problems/disorders: Cataract	3.8	4.4	7.3	0.7	-2.7	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	4.9	5.8	-2.2	-2.0	-2.4
Osteoporosis (self-reported)	3.7	4.6	8.2	2.9	1.1	2.0
Breast cancer (self-reported)	3.5	4.2	6.6	0.7	2.6	2.4
Nervous feelings	3.4	6.3	8.6	-2.9	-2.3	-2.3
Pulse rate	3.4	5.8	7.6	-2.2	-2.2	-2.8
Pain experienced in last month	3.4	5.6	14.6	3.8	1.0	1.1
Alzheimer’s Disease (including proxy)	3.3	4.7	6.0	2.0	2.4	2.1
Impedance of leg (right)	3.3	15.8	23.2	-4.8	-2.7	-4.1
Age when periods started (menarche)	3.3	7.9	11.0	-3.3	-1.5	-3.2
Diabetes (self-reported)	3.2	5.0	7.3	-1.0	-2.7	-2.6
Basal cell carcinoma (self-reported)	3.2	3.8	7.7	2.8	1.6	1.0
Number of self-reported non-cancer illnesses	3.1	5.3	8.5	-2.9	-1.9	-2.0
Impedance of leg (left)	3.0	14.7	18.1	-4.3	-2.8	-4.2
Heart attack	3.0	3.8	4.6	-2.1	-1.5	-2.1
Blood White Count	2.9	21.5	36.6	-6.0	-3.1	-4.2
Lung FEV1/FVC ratio	2.9	14.8	20.6	-4.5	-2.7	-4.1
Stomach or abdominal pain in last month	2.9	3.6	4.5	-1.5	-2.1	-2.0
Mouth/teeth dental problems: Bleeding gums	2.9	3.8	5.0	2.2	1.7	1.9
Type 2 Diabetes (T2D) (2018)	2.8	5.2	6.2	-2.2	-2.1	-2.5
Headache pain in last month	2.8	4.8	10.4	-3.2	-1.2	-1.6
Overall health rating	2.8	6.0	12.6	-3.5	-1.4	-1.9
Osteoarthritis (self-reported)	2.8	3.6	4.9	1.9	1.5	2.2
Fed-up feelings	2.7	4.9	5.9	-2.4	-2.3	-1.9
Qualifications: CSEs or equivalent	2.7	3.6	8.2	-2.9	-0.9	-1.3
Medication: Levothyroxine sodium	2.7	4.7	8.8	-3.0	-1.3	-1.9
Fluid intelligence score	2.7	5.6	6.1	2.2	2.4	2.5
Exposure to tobacco smoke outside home	2.7	3.7	6.6	-2.6	-1.3	-1.7
Supplements: Vitamin C	2.7	3.1	7.8	-2.8	-1.0	-0.9
Had other major operations	2.6	3.1	6.3	2.5	1.3	1.2
Loud music exposure frequency	2.6	2.8	7.8	2.8	0.4	0.7
Pulse rate, automated reading	2.6	8.5	10.4	-3.2	-2.7	-2.8
Intelligence (Savage-Jansen 2018)	2.5	7.8	10.9	1.6	3.2	3.3
HbA1C	2.5	2.8	4.0	-2.0	-1.5	-1.5
Alcohol usually taken with meals	2.5	4.1	6.1	-0.8	-2.5	-2.4
Mouth/teeth dental problems: Loose teeth	2.5	3.0	4.6	-0.9	-2.1	-1.9
Medication: Cholesterol lowering	2.4	3.8	6.7	-2.6	-1.1	-1.8
Suffer from ‘nerves’	2.4	3.8	5.3	-1.7	-1.8	-2.3
Medication: Atorvastatin	2.4	2.9	6.1	-2.5	-1.2	-1.1
Ulcerative Colitis (UC)	2.3	4.3	5.6	-2.4	-1.6	-2.2
Bipolar Disorder (2011)	2.3	2.2	6.4	-2.5	0.3	-0.3
Hypothyroidism (self reported)	2.3	5.2	7.8	-2.8	-1.8	-2.2
Financial difficulties in last 2 years	2.3	3.1	4.7	-0.3	2.2	2.1
Medication: Blood pressure	2.3	4.4	9.4	-3.1	-1.2	-1.5
Diabetes diagnosed by doctor	2.2	3.6	4.7	-1.2	-2.2	-2.2
Wears glasses or contact lenses	2.2	2.5	3.5	1.1	1.9	1.7
Heart attack/myocardial infarction (self-reported)	2.2	2.8	3.5	-1.8	-1.3	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	4.4	2.1	1.2	1.3
Fasting Glucose	2.0	2.4	3.4	0.9	1.8	1.7
Medication for hormone replacement therapy	2.0	2.2	4.2	-0.7	-2.1	-1.4
Medication: Ramipril	2.0	2.6	7.2	-2.7	0.7	-0.2
Prospective memory result	2.0	2.5	3.2	1.8	1.2	1.6
High cholesterol (Self-reported)	2.0	3.6	9.3	-3.0	-0.4	-1.1
Hand grip strength (left)	1.9	5.0	8.0	-2.8	2.1	1.7
Alcohol intake versus 10 years previously	1.9	2.8	4.3	-2.1	-1.3	-1.6
Medication: Lansoprazole	1.9	2.1	3.3	-0.0	-1.8	-1.8
Alcohol intake frequency.	1.9	4.5	6.1	-1.8	-2.0	-2.5
Illnesses of siblings: Diabetes	1.9	2.3	4.0	-0.5	-1.6	-2.0
Mother’s age at death	1.9	2.4	6.7	2.6	-0.4	0.5
Cardiovascular Disease	1.8	5.8	11.6	-3.4	-1.4	-2.0
Hypothyroidism/myxoedema (self-reported)	1.8	3.5	6.4	-2.5	-1.1	-1.7
Qualifications: College or University degree	1.8	5.7	11.8	3.4	1.6	1.6
Miserableness	1.8	3.2	4.5	-0.9	-2.0	-2.1
Commuting to job workplace: Cycle	1.8	2.2	2.7	-1.2	-1.5	-1.6
Systolic Blood Pressure	1.7	8.8	13.0	-2.2	-2.9	-3.6
Systolic blood pressure, automated reading	1.7	4.9	7.6	-0.1	-2.8	-2.7
Hand grip strength (right)	1.7	4.6	8.5	-2.9	1.7	1.5
Medication: Atenolol	1.7	2.1	3.0	-1.7	-0.9	-1.6
Leg fat-free mass (right)	1.7	9.1	12.4	2.8	2.7	3.5
Leg predicted mass (right)	1.7	9.0	12.3	2.8	2.6	3.5
Ever smoked	1.7	2.9	3.9	1.1	1.9	2.0
Diastolic blood pressure, automated reading	1.7	5.3	8.8	-0.7	-3.0	-2.6
Prostate Cancer	1.6	2.2	3.8	-1.3	-1.9	-1.1
Type 2 Diabetes (T2D) (2012)	1.6	1.8	2.3	-1.5	-1.1	-1.3
BMI	1.5	8.7	13.2	2.8	2.3	3.6
Number of treatments/medications taken	1.5	2.8	4.2	-2.0	-1.6	-1.2
Leg fat-free mass (left)	1.5	8.2	12.0	2.4	2.6	3.5
Leg predicted mass (left)	1.5	8.1	12.0	2.4	2.6	3.5
Qualifications: A levels/AS levels or equivalent	1.5	3.4	3.8	1.7	1.9	2.0
Bipolar Disorder (2018)	1.4	2.2	4.1	0.4	2.0	1.5
Schizophrenia (2018)	1.4	2.8	5.2	-0.2	-2.3	-1.8
HDL Cholesterol	1.4	2.4	2.9	1.6	1.3	1.7
Time employed in main current job	1.4	1.6	3.8	-0.4	-2.0	-0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	3.0	1.7	1.3	1.6
Shortness of breath walking on level ground	1.4	1.7	2.8	-0.1	-1.7	-1.5
Ever taken oral contraceptive pill	1.4	1.6	2.7	0.9	1.6	1.1
Eye problems/disorders: Glaucoma	1.4	1.7	2.6	0.8	1.6	1.3
Verbal and Numeric Reasoning (VNR)	1.3	3.1	3.3	1.7	1.7	1.8
Father’s age at death	1.3	1.8	4.4	2.1	0.5	0.8
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.1	-2.5	-0.1	-0.5
Number of live births	1.3	1.9	2.3	1.2	1.5	1.4
Lung cancer (father)	1.3	1.5	2.8	1.0	1.0	1.7
Forced vital capacity (FVC), Best measure	1.3	4.7	7.3	-0.7	2.7	2.5
Comparative height size at age 10	1.3	7.1	11.1	0.7	3.1	3.3
Illnesses of father: Heart disease	1.3	1.8	4.2	-2.0	-1.0	-0.5
Back pain experienced in last month	1.3	1.9	4.6	-2.2	-0.7	-0.8
Tinnitus: Yes, now most or all of the time	1.3	1.5	2.1	0.8	-1.4	-1.4
Depressed Affect (Nagel 2018)	1.2	2.6	3.3	-1.3	-1.8	-1.6
Alzheimer’s Disease (in father)	1.2	1.3	1.6	1.3	1.1	1.0
Irritable Bowel Disease (IBD)	1.2	3.0	4.1	-2.0	-1.4	-1.7
Heel T-Score	1.2	9.3	22.8	4.8	1.5	1.7
High blood pressure	1.2	3.3	4.2	-2.0	-1.6	-1.7
Neuroticism score	1.2	2.4	4.1	-2.0	-1.3	-1.2
Asthma	1.2	2.4	3.8	-1.4	-1.9	-1.2
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	3.1	-1.8	-0.6	-1.1
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.2	0.2	-1.8	-1.1
Hypertension (Self-reported)	1.2	3.3	3.9	-2.0	-1.7	-1.7
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.3	1.8	0.8	0.9
Impedance of whole body	1.2	6.1	9.5	-2.2	-2.0	-3.1
Schizophrenia (2014)	1.1	2.5	4.1	-0.5	-2.0	-1.7
Allergy or Eczema	1.1	3.0	4.8	-2.2	-1.4	-1.5
Sensitivity / hurt feelings	1.1	1.8	2.7	-1.7	-1.2	-1.1
Allergy	1.1	2.6	3.1	1.8	1.7	1.4
Medication: Simvastatin	1.1	1.5	2.6	-1.6	-0.7	-1.2
Weight	1.1	5.5	8.8	1.9	2.0	3.0
Whole body fat-free mass	1.1	6.0	9.7	1.5	2.5	3.1
Average weekly red wine intake	1.1	1.6	3.6	1.9	0.8	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.6	1.3	0.8	1.1
Basal metabolic rate	1.1	6.3	10.1	1.6	2.5	3.2
Irritability	1.1	1.8	3.0	0.9	1.2	1.7
Vascular/heart problems diagnosed by doctor	1.1	3.0	5.2	2.3	1.3	1.5
Age at First Birth	1.0	1.5	2.9	1.7	0.6	1.1
LDL Cholesterol	1.0	1.5	3.9	-2.0	-0.6	-0.6
Blood Red Count	1.0	9.3	13.0	-1.7	-3.6	-3.4
Vitamin and mineral supplements	1.0	1.3	1.7	0.8	-1.3	-1.3
Taking other prescription medications	1.0	1.5	2.2	-1.1	-1.5	-1.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	1.8	-1.3	-1.1	-1.3
Falls in the last year	1.0	1.4	2.2	1.5	0.8	1.2
Glaucoma (self-reported)	1.0	1.2	1.6	0.8	1.1	1.3
Emphysema/chronic bronchitis	1.0	1.1	1.4	0.9	1.0	1.2
Medication: Ibuprofen	1.0	1.1	2.2	-1.5	-0.4	-1.1
Whole body water mass	1.0	5.8	9.2	1.5	2.4	3.0
Myopia	1.0	1.4	2.2	-1.5	-0.9	-1.1
Crohns Disease (2017)	0.9	2.1	2.6	-1.6	-1.5	-1.2
Major Depression (MDD)	0.9	1.0	1.6	0.2	1.3	1.2
Neuroticism	0.9	2.2	3.0	-1.7	-1.4	-1.3
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.2	0.6	0.8	1.5
Hayfever, allergic rhinitis or eczema	0.9	2.0	2.3	-1.5	-1.3	-1.4
Had menopause	0.9	1.2	1.7	1.0	0.9	1.3
Trunk fat-free mass	0.9	5.2	8.3	0.9	2.5	2.9
Arm fat mass (right)	0.9	3.6	5.1	2.1	1.2	2.3
Trunk predicted mass	0.9	5.2	8.4	0.9	2.5	2.9
Pulse wave reflection index	0.9	1.2	2.2	0.6	1.5	0.9
High blood pressure (siblings)	0.9	1.3	2.0	-1.4	-1.1	-0.9
Arm fat percentage (left)	0.9	3.7	7.6	2.8	0.5	1.8
Illnesses of father: None of the above (group 1)	0.9	1.1	2.9	1.7	-0.5	-0.5
Arm fat mass (left)	0.9	3.7	5.2	2.1	1.1	2.3
Medication: Bendroflumethiazide	0.9	1.3	2.5	-1.6	-0.9	-0.8
Heart disease (siblings)	0.9	1.1	1.8	-0.7	-1.1	-1.4
Alcohol drinker status: Previous	0.9	1.0	1.5	0.0	-1.2	-1.2
Neuroticism (Nagel 2018)	0.8	1.9	3.2	-1.8	-1.2	-1.0
Neuroticism (2016)	0.8	1.1	1.7	-1.3	-0.7	-1.1
Blood Eosinophil Count	0.8	6.1	12.5	-3.5	-1.2	-2.1
Multivitamins +/- minerals	0.8	1.1	3.2	-1.8	0.1	-0.0
Body mass index (BMI)	0.8	3.5	5.2	2.1	1.0	2.3
Past tobacco smoking	0.8	1.5	2.5	-0.5	-1.3	-1.6
Forced vital capacity (FVC)	0.8	3.1	4.5	-0.7	2.0	2.1
Pain all over the body in last month	0.8	0.8	1.2	0.6	-0.9	-1.1
Illnesses of siblings	0.8	1.1	1.5	0.7	1.1	1.2
Arm fat percentage (right)	0.8	3.2	6.8	2.6	0.4	1.6
Depression (self-reported)	0.8	1.0	1.2	1.1	0.8	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	3.9	-2.0	1.6	1.0
Length of working week for main job	0.8	0.8	1.4	1.1	0.2	1.2
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.1	-0.1	-1.4	-0.9
Eye problems/disorders: None of the above	0.8	0.9	1.2	-0.7	1.1	1.0
Medication: Blood pressure	0.8	1.5	1.6	-1.2	-1.3	-1.1
Heart disease (mother)	0.8	0.9	1.2	-0.7	1.1	1.0
Arm predicted mass (right)	0.8	3.9	6.8	0.7	2.1	2.6
Alcohol drinker status: Never	0.8	1.0	1.5	1.2	-1.2	-0.2
Depression (Nagel 2018)	0.7	1.0	1.2	-1.0	-0.9	-1.1
Worry (Nagel 2018)	0.7	1.4	3.0	-1.7	-0.8	-0.8
Lupus	0.7	1.1	2.2	0.1	1.5	1.1
Lung FVC	0.7	3.6	7.6	0.8	1.6	2.8
Peak expiratory flow (PEF)	0.7	1.7	4.7	-2.2	0.2	-0.5
Arm fat-free mass (right)	0.7	3.6	6.2	0.7	2.0	2.5
Neck or shoulder pain in last month	0.7	1.0	1.4	-1.1	0.4	1.2
Medication: Allopurinol	0.7	0.9	1.8	0.2	-1.0	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.2	-0.9	1.1	0.8
Asthma (self-reported)	0.7	1.5	2.8	-0.9	-1.7	-0.8
Commuting to job workplace: Public transport	0.7	0.8	1.1	0.6	1.0	1.0
Supplements: Fish oil (including cod liver oil)	0.7	0.9	2.4	-1.6	0.6	-0.1
Number of operations (self-reported)	0.7	1.0	2.2	1.5	-0.8	-0.5
Average weekly beer plus cider intake	0.7	1.0	1.3	0.9	1.0	1.1
Age started oral contraceptive pill	0.7	0.9	1.2	0.7	1.1	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.0	-0.5	1.0	0.8
Trunk fat mass	0.6	2.5	3.5	1.9	0.9	1.8
Number of incorrect matches in round	0.6	1.0	1.6	1.0	1.3	0.6
Hair/balding pattern: Pattern 3	0.6	0.8	1.4	-0.1	1.0	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.9	-1.4	-0.3	-0.1
Exposure to tobacco smoke at home	0.6	0.6	1.2	1.1	0.5	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.2	-0.6	-1.1	-1.0
Blood clot in the leg (DVT)	0.6	0.8	1.7	1.3	0.6	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	0.0	-1.2	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.9	1.4	0.4	-0.3
Medication for pain relief, constipation, heartburn	0.6	1.1	1.4	1.2	1.0	0.9
Whole body fat mass	0.6	2.6	3.5	1.9	0.9	1.9
Long-standing illness, disability or infirmity	0.6	0.9	0.9	-1.0	-1.0	-0.9
Qualifications: nursing, teaching	0.6	0.9	2.5	1.6	-0.5	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.7	0.7	-1.3	-0.4
Supplements: Calcium	0.6	0.7	1.3	0.8	0.1	1.1
Arm predicted mass (left)	0.6	3.0	5.6	0.5	1.8	2.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.5	1.2	-0.5	0.3
Qualifications: None of the above	0.5	1.2	1.4	-1.2	-1.2	-0.9
Worrier / anxious feelings	0.5	0.9	1.2	-0.7	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.3	-2.3	0.4	0.1
Comparative body size at age 10	0.5	1.4	3.2	1.8	0.8	0.5
Pulse wave peak to peak time	0.5	0.6	1.2	-0.4	0.6	1.1
Medication: Seretide 50 evohaler	0.5	0.5	1.0	0.7	-1.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.9	1.4	0.3	0.7
Arm fat-free mass (left)	0.5	2.6	5.0	0.4	1.6	2.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.8	1.3	-0.1	0.3
Ulcerative Colitis	0.4	0.6	0.7	-0.9	-0.7	-0.6
Smoking Status	0.4	1.0	2.5	-1.6	-0.4	-0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.4	1.2	0.5	0.4
Pack years adult smoking proportion	0.4	0.7	1.5	-0.1	-1.2	-0.7
Trunk fat percentage	0.4	1.5	3.4	1.8	0.1	1.0
Maternal smoking around birth	0.4	0.6	0.9	-0.6	0.6	1.0
High blood pressure (mother)	0.4	0.6	1.1	-0.3	-1.1	-0.7
Hair/balding pattern: Pattern 2	0.4	0.6	1.2	-1.1	-0.7	-0.2
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	0.6	-0.5	-0.9
Hair/balding pattern: Pattern 4	0.4	0.9	2.2	1.5	0.1	0.5
Medication: Omeprazole	0.4	0.5	1.0	1.0	-0.4	0.5
Leg fat mass (right)	0.4	1.5	2.6	1.2	0.6	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.6	-0.9	-0.4
Smoking status: Previous	0.4	0.7	1.4	0.1	0.8	1.2
Loneliness, isolation	0.4	0.5	0.6	-0.8	-0.7	-0.7
Ever had bowel cancer screening	0.4	0.5	1.5	1.2	0.0	0.2
Friendships satisfaction	0.4	0.5	1.2	-1.1	-0.1	-0.5
Illnesses of father: High blood pressure	0.4	0.5	1.1	-1.0	0.6	0.2
Risk taking	0.4	0.7	1.0	0.3	1.0	0.9
Fractured/broken bones in last 5 years	0.4	0.5	0.9	-0.1	-0.8	-0.9
Leg fat mass (left)	0.4	1.6	2.7	1.3	0.7	1.6
Crohns Disease (2012)	0.3	0.6	0.9	-1.0	-0.7	-0.5
Rheumatoid Arthritis	0.3	0.4	0.7	-0.8	-0.5	-0.5
Respiratory disease	0.3	0.6	0.9	-1.0	-0.8	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.5	0.8	0.0	-0.9	-0.7
Severe depression (siblings)	0.3	0.4	0.7	-0.8	-0.2	-0.6
Average weekly fortified wine intake	0.3	0.3	0.4	0.7	0.4	0.7
Sitting height	0.3	2.3	3.5	0.6	1.8	1.9
Chronic bronchitis/emphysema (father)	0.3	0.4	0.8	-0.3	0.5	0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.1	1.0	-0.8	-0.3
Mouth/teeth dental problems	0.3	0.4	0.7	0.5	-0.8	-0.6
Mouth/teeth dental problems: Dentures	0.3	0.4	1.3	-1.1	0.1	0.0
Medication: Amlodipine	0.3	0.4	0.5	-0.6	-0.7	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.6	0.7	0.5
Body fat percentage	0.3	1.3	3.0	1.7	0.0	1.0
Chest pain or discomfort	0.3	0.5	1.1	-0.3	-1.0	-0.6
Age at last live birth	0.3	0.4	0.6	-0.8	-0.3	-0.7
Family relationship satisfaction	0.3	0.4	0.8	-0.9	0.5	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.1	1.1	-0.0	-0.1
Hearing aid user	0.3	0.3	0.5	0.7	-0.6	-0.3
Pack years of smoking	0.3	0.5	1.3	0.2	-1.1	-0.5
Breast Cancer	0.2	0.4	1.1	1.0	0.0	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.3	0.7	0.6
Height	0.2	3.0	5.1	-1.6	2.3	1.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.4	-0.4	-0.5	-0.7
Angina	0.2	0.3	0.6	-0.8	0.3	-0.4
Diabetes (mother)	0.2	0.3	0.6	-0.8	-0.5	-0.0
Hearing difficulty/problems with background noise	0.2	0.4	0.6	-0.4	-0.6	-0.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.2	-0.5	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.4	-0.4	0.3	0.7
Impedance of arm (right)	0.2	1.0	2.3	0.2	-0.8	-1.5
Noisy workplace	0.2	0.2	0.5	0.7	-0.1	0.4
Illnesses of mother	0.2	0.2	0.4	0.7	0.3	0.4
Standing height	0.2	2.2	4.5	-0.5	2.1	1.4
Breastfed as a baby	0.2	0.3	0.5	-0.3	-0.7	-0.6
Tense / ‘highly strung’	0.2	0.4	1.0	-1.0	-0.3	0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	-0.8	0.1	-0.5
Medication: Paracetamol	0.2	0.3	0.4	-0.6	-0.5	-0.6
Number of children fathered	0.2	0.3	0.5	-0.7	0.4	-0.2
Angina (self-reported)	0.2	0.3	0.6	-0.8	0.4	-0.4
Migraine (self-reported)	0.2	0.3	0.8	-0.9	0.0	-0.2
Mean time to correctly identify matches	0.2	0.4	1.1	1.1	-0.1	-0.0
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.6	0.5	-0.1
Knee pain experienced in last month	0.2	0.2	0.6	-0.4	-0.0	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.6	-0.3	-0.4
Guilty feelings	0.2	0.4	0.8	-0.9	0.5	0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.2	0.1	-0.5	-0.5
Ovarian Cancer	0.1	0.1	0.3	0.1	-0.5	-0.2
Mean Putamen Volume	0.1	0.1	0.2	-0.4	-0.1	0.0
Blood Platelet Count	0.1	1.0	1.2	-0.9	-1.0	-1.1
Hair Pigment	0.1	2.2	3.7	0.8	1.5	1.9
Relative age of first facial hair	0.1	0.3	0.4	0.3	-0.7	-0.6
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.1	0.3	-0.4	-0.1
Ever had hysterectomy (womb removed)	0.1	0.1	0.3	-0.2	0.3	0.6
Medication: Co-codamol	0.1	0.1	0.1	0.4	-0.2	0.0
Diabetes (father)	0.1	0.1	0.1	-0.2	0.2	0.3
Townsend deprivation index at recruitment	0.1	0.1	0.1	-0.2	0.2	0.4
Relative age voice broke	0.1	0.1	0.4	0.6	-0.0	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	0.6	-0.7	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.4	0.3	0.2
Supplements: Glucosamine	0.1	0.1	0.3	0.1	-0.5	0.2
Happiness	0.1	0.1	0.3	-0.6	0.2	-0.0
Impedance of arm (left)	0.1	0.6	1.3	0.4	-0.5	-1.2
Gout (self-reported)	0.1	0.2	0.3	-0.3	0.3	-0.5
Number of full brothers	0.1	0.1	0.1	-0.3	0.3	0.4
Worry too long after embarrassment	0.1	0.2	0.3	-0.4	-0.5	0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.1	0.6	0.5
Age at first live birth	0.1	0.1	0.2	-0.4	-0.0	-0.5
Number of full sisters	0.1	0.1	0.1	-0.4	0.1	-0.2
Had major operations	0.1	0.1	0.2	0.4	0.1	0.1
Medication: Aspirin	0.1	0.2	0.5	-0.7	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.1	0.2	-0.5	0.1	-0.4
Mood swings	0.1	0.2	0.4	0.0	-0.7	-0.3
Commuting to job workplace: Walk	0.1	0.1	0.2	0.4	-0.5	0.0
Mineral and other dietary supplements	0.1	0.1	0.3	0.2	-0.5	-0.2
Financial situation satisfaction	0.1	0.2	0.3	0.5	0.4	0.1
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	-0.5	-0.1	-0.0
Medication: Lisinopril	0.1	0.2	0.3	0.4	0.2	0.6
Leg fat percentage (left)	0.1	0.2	0.4	0.4	-0.7	0.2
Unable to work because of sickness or disability	0.1	0.1	0.2	-0.4	-0.2	-0.5
Reaction Time	0.0	0.0	0.1	0.3	-0.0	-0.2
Primary Biliary Cirrhosis	0.0	0.0	0.0	0.0	0.2	-0.1
Tanning	0.0	0.1	0.3	0.1	0.4	-0.5
Supplements: Zinc	0.0	0.0	0.0	0.1	-0.1	0.0
Current tobacco smoking	0.0	0.0	0.0	-0.0	0.2	-0.1
Waist circumference	0.0	0.1	0.2	-0.1	-0.5	0.1
Leg fat percentage (right)	0.0	0.2	0.4	0.0	-0.6	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.1	0.3	0.1	-0.2
Leg pain on walking	0.0	0.0	0.1	-0.0	-0.1	-0.3
Medication: Aspirin	0.0	0.0	0.1	0.1	-0.1	0.3
Smoking status: Current	0.0	0.1	0.1	0.3	0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.2	-0.4	-0.1	-0.0
Medication: Paracetamol	0.0	0.0	0.0	0.0	0.2	-0.2

Hub : Genes

RASD1

Models

Trait associations