Hub : Genes

RASGRP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.3400 0.1040 0.00077 0.015 NA 0.106 NA 0.102 0.12 NA 0.0005 NA 0.00064
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0284 0.0197 0.00380 0.003 0.011 0.008 NA 0.004 0.12 0.016 0.0370 NA 0.11000

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.3 2.0 2.9 1.0 -1.7
Bipolar Disorder or Schizophrenia 0.5 1.2 1.4 1.0 -1.2
Depressed Affect (Nagel 2018) 1.6 3.3 4.4 2.1 -1.5
Depression (Nagel 2018) 0.7 1.1 1.3 0.9 -1.2
Intelligence (Savage-Jansen 2018) 0.6 1.7 2.4 -1.0 1.6
Neuroticism (Nagel 2018) 0.5 1.1 1.8 1.3 -0.6
Schizophrenia (2018) 0.1 0.2 0.4 0.6 -0.2
Schizophrenia vs Biploar Disorder 0.8 1.1 2.0 -0.3 1.4
Worry (Nagel 2018) 0.5 1.0 1.4 1.2 -0.8
Alzheimer’s Disease (in mother) 0.4 0.4 0.8 0.9 -0.3
Alzheimer’s Disease (in father) 0.0 0.0 0.1 0.3 -0.0
Alzheimer’s Disease (including proxy) 1.1 1.5 3.1 1.8 0.0
Crohns Disease (2017) 1.3 2.9 5.7 -0.1 -2.4
Irritable Bowel Disease (IBD) 1.0 2.3 4.4 -0.4 -2.1
Ulcerative Colitis (UC) 0.2 0.4 0.7 -0.2 -0.8
Major Depression (MDD) 0.3 0.4 0.8 -0.0 -0.9
Reaction Time 0.6 1.1 2.0 1.4 0.3
Verbal and Numeric Reasoning (VNR) 0.9 2.1 2.9 -1.2 1.7
Breast Cancer 1.5 3.6 7.3 -2.7 0.0
Ovarian Cancer 0.4 0.5 0.8 0.5 0.9
Prostate Cancer 6.7 9.5 9.5 3.1 -3.1
Age at First Birth 1.2 1.7 2.1 1.4 1.2
Bipolar Disorder (2011) 0.5 0.4 0.9 0.0 -0.9
Body Mass Index (BMI) (2010) 0.4 0.6 1.1 -0.2 1.1
Coronary Artery Disease (CAD) 0.0 0.0 0.0 -0.0 -0.2
Crohns Disease (2012) 1.1 1.8 3.7 -0.2 -1.9
Mean Putamen Volume 0.6 0.7 0.8 0.9 0.7
Fasting Glucose 0.0 0.0 0.1 -0.2 0.2
HbA1C 0.2 0.2 0.3 -0.6 -0.2
HDL Cholesterol 2.2 3.6 6.2 1.0 2.5
LDL Cholesterol 0.0 0.0 0.0 -0.2 0.1
Lupus 0.8 1.2 1.5 -0.9 1.2
Neuroticism (2016) 0.1 0.1 0.2 0.4 -0.4
Primary Biliary Cirrhosis 0.3 0.4 0.5 0.7 -0.6
Rheumatoid Arthritis 0.1 0.1 0.2 0.5 -0.3
Schizophrenia (2014) 0.3 0.6 0.8 0.9 -0.7
Triglycerides 1.0 1.6 2.2 -1.5 -1.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 -0.1 -0.1
Ulcerative Colitis 0.5 0.7 1.4 0.1 -1.2
Blood Eosinophil Count 1.7 12.8 19.2 -4.4 2.5
Blood Platelet Count 2.3 26.5 49.6 -7.0 1.9
Blood Red Count 0.0 0.2 0.3 0.6 0.3
Blood White Count 0.6 4.7 5.3 -2.0 2.3
Heel T-Score 0.0 0.3 0.6 -0.0 -0.8
BMI 0.5 2.8 4.8 -2.2 -0.9
Height 0.4 6.9 7.0 -2.6 2.6
Waist Hip Ratio (WHR) 2.0 9.0 13.5 3.7 -2.1
Systolic Blood Pressure 1.6 8.1 10.2 3.2 -2.4
Smoking Status 1.0 2.5 3.0 1.4 -1.7
Allergy or Eczema 0.0 0.0 0.0 0.1 0.2
Cardiovascular Disease 1.2 3.8 7.1 0.7 -2.7
Hypothyroidism (self reported) 0.6 1.4 1.5 1.1 -1.2
Respiratory disease 0.6 1.3 2.5 -0.4 -1.6
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.1 1.0 -0.3
Lung FEV1/FVC ratio 1.6 8.3 15.9 -4.0 0.9
Lung FVC 1.5 7.8 12.9 3.6 1.6
Neuroticism 0.5 1.3 2.0 1.4 -0.7
Chronotype (morning person) 0.0 0.0 0.0 0.2 -0.2
Hair Pigment 0.0 1.3 2.5 -1.6 0.2
Tanning 0.3 3.1 4.5 1.3 -2.1
Hand grip strength (left) 0.0 0.0 0.0 -0.0 0.1
Number of treatments/medications taken 2.6 4.6 9.1 0.3 -3.0
Average weekly spirits intake 0.4 0.4 0.6 0.5 0.8
Sensitivity / hurt feelings 0.6 1.1 2.1 0.4 -1.4
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.1 0.3 0.0
Hearing difficulty/problems: Yes 0.9 1.3 2.6 -0.0 -1.6
Relative age of first facial hair 0.3 0.6 1.2 -1.1 0.1
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.1 0.2 0.0
Ever used hormone-replacement therapy (HRT) 0.0 0.0 0.0 -0.2 -0.1
Ever had hysterectomy (womb removed) 0.5 0.5 0.6 -0.8 -0.7
Systolic blood pressure, automated reading 0.9 2.6 2.7 1.6 -1.6
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.4 1.8 0.1
Angina 1.7 2.2 4.4 -2.1 0.3
Medication for hormone replacement therapy 1.0 1.1 1.5 -1.2 0.9
Vitamin and mineral supplements 0.9 1.2 2.3 -1.5 0.4
Supplements: Zinc 0.0 0.0 0.1 -0.1 -0.3
Medication: Co-codamol 1.5 1.8 2.4 -1.1 1.5
Medication: Metformin 0.2 0.3 0.3 0.5 -0.5
Diabetes (father) 1.0 1.3 2.5 0.1 1.6
Diabetes (mother) 0.2 0.2 0.5 -0.7 0.1
Severe depression (siblings) 0.2 0.2 0.3 -0.4 -0.6
Pack years adult smoking proportion 0.3 0.4 0.7 0.8 -0.4
Impedance of leg (right) 0.2 1.1 2.3 0.2 1.5
Leg fat-free mass (left) 0.3 1.6 2.6 -1.6 0.8
Trunk fat percentage 1.5 6.2 11.9 -3.5 0.7
Hand grip strength (right) 0.3 0.7 1.1 -1.1 -0.5
Townsend deprivation index at recruitment 1.6 2.3 3.7 1.9 -0.9
Current tobacco smoking 1.0 1.7 2.2 1.1 -1.5
Average weekly fortified wine intake 2.2 2.6 3.8 -1.2 1.9
Maternal smoking around birth 0.0 0.0 0.0 0.1 0.1
Fed-up feelings 1.5 2.7 3.6 1.9 -1.3
Frequency of unenthusiasm / disinterest in last 2 weeks 2.0 2.6 2.8 1.7 -1.6
Relative age voice broke 0.8 1.3 1.4 -1.1 1.2
Taking other prescription medications 1.3 2.1 3.5 0.8 -1.9
Age when periods started (menarche) 0.7 1.6 3.1 -1.8 0.1
Bilateral oophorectomy (both ovaries removed) 1.8 2.0 3.6 0.7 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 0.9 0.9 -0.4
Tinnitus: Yes, but not now, but have in the past 1.3 1.3 2.7 -0.2 1.6
Qualifications: CSEs or equivalent 0.7 0.9 1.7 -0.3 -1.3
Serious illness, injury or assault to yourself 0.6 0.7 0.8 0.7 0.9
High blood pressure 2.7 7.5 14.0 1.0 -3.7
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 -0.3 0.8
Multivitamins +/- minerals 0.3 0.4 0.6 0.8 -0.4
Stomach or abdominal pain in last month 0.6 0.8 1.6 -0.1 1.3
Supplements: Glucosamine 0.3 0.4 0.7 -0.3 -0.8
Diverticular disease/diverticulitis (self-reported) 3.0 3.5 4.8 -2.2 1.5
Medication: Atenolol 1.5 1.8 3.1 -1.8 -0.7
Medication: Levothyroxine sodium 0.2 0.4 0.4 0.6 -0.6
Sitting height 0.6 4.4 8.4 -0.7 2.9
Chronic bronchitis/emphysema (father) 1.5 1.7 2.8 0.8 -1.7
High blood pressure (mother) 0.4 0.6 1.1 -1.0 0.4
Body mass index (BMI) 0.6 2.7 3.2 -1.8 -1.5
Impedance of leg (left) 0.3 1.4 2.8 0.1 1.7
Leg predicted mass (left) 0.4 1.9 3.0 -1.7 0.9
Trunk fat mass 1.1 4.6 8.6 -2.9 0.7
Waist circumference 0.2 0.8 1.4 -1.2 0.3
Number of incorrect matches in round 0.9 1.5 1.7 1.2 -1.3
Past tobacco smoking 0.8 1.5 1.8 -1.4 1.0
Alcohol usually taken with meals 0.7 1.1 1.8 -1.4 0.6
Nervous feelings 1.4 2.6 3.4 1.3 -1.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 2.8 -0.1 1.7
Hearing difficulty/problems with background noise 2.0 3.3 3.4 1.8 -1.8
Hair/balding pattern: Pattern 2 1.0 1.3 2.0 1.4 -0.8
Had menopause 1.6 2.0 3.9 -2.0 0.2
Had other major operations 2.2 2.7 5.2 0.5 2.3
Forced vital capacity (FVC) 1.6 6.0 9.4 1.6 3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.3 0.2 0.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.7 -0.2 -0.8
Qualifications: None of the above 0.2 0.5 0.7 0.5 -0.9
Financial difficulties in last 2 years 0.0 0.0 0.0 -0.2 -0.0
Mouth/teeth dental problems 0.6 0.9 1.3 -1.1 0.7
Heart attack 0.2 0.3 0.5 -0.7 0.3
Allergy 0.1 0.3 0.5 0.7 0.3
Pain all over the body in last month 0.3 0.3 0.4 0.5 0.6
Diabetes (self-reported) 0.4 0.6 1.1 0.3 -1.0
Hayfever/allergic rhinitis (self-reported) 1.4 1.8 3.6 -0.0 -1.9
Medication: Ramipril 0.8 1.0 1.9 -1.4 -0.4
Medication: Simvastatin 0.2 0.3 0.6 -0.8 -0.3
Fluid intelligence score 0.9 1.9 2.6 -1.6 1.1
Illnesses of siblings 0.9 1.3 2.0 0.8 1.4
Neuroticism score 1.0 2.1 3.1 1.8 -1.0
Weight 0.5 2.4 4.5 -2.1 0.6
Impedance of arm (right) 2.4 11.1 15.8 -2.5 4.0
Arm fat percentage (right) 1.1 4.2 8.4 -2.9 -0.2
Trunk fat-free mass 0.0 0.1 0.1 0.3 0.3
Hip circumference 2.3 10.0 13.1 -3.6 2.7
Time employed in main current job 0.4 0.5 0.9 -0.1 1.0
Alcohol intake versus 10 years previously 2.5 3.8 5.6 2.4 -1.4
Father’s age at death 3.4 4.6 5.4 -1.9 2.3
Worrier / anxious feelings 1.7 3.1 3.8 1.6 -1.9
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 5.3 2.3 -0.5
Falls in the last year 0.4 0.5 0.9 0.2 1.0
Hair/balding pattern: Pattern 3 0.2 0.3 0.4 0.5 0.6
Number of live births 0.1 0.2 0.3 -0.3 0.6
Forced expiratory volume in 1-second (FEV1) 1.9 6.3 12.3 -0.4 3.5
Pulse rate 5.2 8.8 17.5 -4.2 -0.2
Happiness 0.1 0.1 0.3 0.1 -0.5
Noisy workplace 2.5 3.1 6.2 -0.0 -2.5
Qualifications: A levels/AS levels or equivalent 2.3 5.2 8.5 -1.4 2.9
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.6 0.3 -0.8
Mouth/teeth dental problems: Dentures 0.8 1.4 2.8 0.1 -1.7
Asthma 0.6 1.3 2.3 -0.5 -1.5
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 2.3 1.5 -0.8
Medication: Cholesterol lowering 0.3 0.4 0.5 0.6 -0.7
Depression (self-reported) 1.3 1.6 2.8 0.7 -1.7
Medication: Lansoprazole 0.3 0.3 0.5 -0.4 -0.7
Prospective memory result 1.5 1.8 2.0 1.4 -1.3
Lung cancer (father) 2.7 3.2 6.2 -0.5 -2.5
Illnesses of mother 0.3 0.4 0.8 -0.1 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.6 14.7 -0.7 3.8
Pulse wave Arterial Stiffness index 0.7 0.8 1.2 -0.6 -1.1
Impedance of arm (left) 2.3 10.5 14.8 -2.5 3.9
Arm fat mass (right) 0.8 3.3 6.6 -2.6 -0.0
Trunk predicted mass 0.0 0.1 0.2 0.4 0.3
Standing height 0.9 9.1 17.3 -1.0 4.2
Length of working week for main job 0.2 0.3 0.4 0.4 -0.6
Exposure to tobacco smoke at home 0.4 0.5 1.0 -1.0 0.1
Breastfed as a baby 0.1 0.1 0.2 0.2 -0.4
Tense / ‘highly strung’ 0.3 0.5 0.6 -0.7 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.5 -0.1 -1.2
Hair/balding pattern: Pattern 4 0.1 0.3 0.6 0.3 -0.8
Birth weight of first child 2.3 4.1 8.1 -0.3 -2.9
Peak expiratory flow (PEF) 1.4 3.1 5.1 -1.1 2.2
Pulse wave reflection index 1.9 2.3 4.3 2.1 -0.6
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.5 -0.2
Loud music exposure frequency 0.3 0.4 0.4 0.6 -0.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 0.7 0.0 0.8
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.4 -0.2 1.2
Blood clot in the leg (DVT) 2.0 2.6 3.5 -1.3 -1.9
Medication: Paracetamol 0.8 1.3 1.3 -1.1 -1.1
Headache pain in last month 0.8 1.4 2.5 0.5 -1.6
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.9 -0.2 0.9
Glaucoma (self-reported) 0.3 0.3 0.7 -0.0 0.8
Gout (self-reported) 1.1 1.6 2.9 0.5 -1.7
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.5 0.6 -0.7
Medication: Amlodipine 0.5 0.7 1.3 0.3 -1.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.2 0.4
Birth weight 0.1 0.1 0.2 0.5 -0.2
Chronic bronchitis/emphysema (mother) 1.6 1.9 3.0 -1.7 -0.9
High blood pressure (siblings) 0.2 0.3 0.3 -0.5 -0.6
Forced vital capacity (FVC), Best measure 1.7 6.2 10.8 1.3 3.3
Body fat percentage 1.1 4.2 8.5 -2.9 0.1
Leg fat percentage (right) 0.5 1.8 2.4 -1.5 -1.1
Arm fat-free mass (right) 0.0 0.1 0.1 -0.1 -0.4
Exposure to tobacco smoke outside home 0.2 0.3 0.5 -0.7 0.1
Comparative body size at age 10 2.1 5.9 11.8 0.3 -3.4
Number of full brothers 0.2 0.3 0.6 -0.1 -0.8
Worry too long after embarrassment 0.5 0.9 1.5 -0.5 1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.1 -1.0 0.2
Wheeze or whistling in the chest in last year 0.8 1.5 2.5 0.7 -1.6
Number of children fathered 0.0 0.0 0.0 -0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 2.4 -1.6 1.2
Age at first live birth 2.1 3.7 5.6 1.3 2.4
Pulse wave peak to peak time 1.2 1.4 2.4 0.7 1.6
Health satisfaction 2.1 2.8 5.5 0.3 -2.3
Shortness of breath walking on level ground 0.7 0.8 1.0 -1.0 0.8
Qualifications: College or University degree 2.5 7.8 9.0 -3.0 2.6
Eye problems/disorders: None of the above 0.3 0.3 0.5 0.3 0.7
Mouth/teeth dental problems: Loose teeth 1.8 2.1 3.7 1.9 -0.7
Emphysema/chronic bronchitis 3.9 4.4 5.7 1.7 -2.4
Medication for pain relief, constipation, heartburn 1.4 2.5 4.8 -0.3 2.2
Neck or shoulder pain in last month 0.2 0.3 0.5 -0.7 0.2
Medication: Blood pressure 1.8 3.2 6.0 -0.6 -2.4
Angina (self-reported) 1.2 1.6 3.2 -1.8 0.1
Migraine (self-reported) 0.4 0.5 0.9 0.4 -0.9
Medication: Ibuprofen 1.7 2.0 2.8 1.7 -1.1
Medication: Allopurinol 0.4 0.5 1.0 0.2 -1.0
Medication: Omeprazole 0.3 0.3 0.7 0.8 -0.2
Medication: Seretide 50 evohaler 0.6 0.7 1.3 0.2 -1.1
Mean time to correctly identify matches 0.7 1.3 2.4 1.5 -0.5
Heart disease (mother) 0.0 0.0 0.0 0.2 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.9 2.3 3.4 -1.8 -1.1
Whole body fat mass 0.8 3.4 6.8 -2.6 0.3
Leg fat mass (right) 0.6 2.1 4.0 -2.0 -0.6
Arm predicted mass (right) 0.0 0.1 0.2 -0.1 -0.4
Pulse rate, automated reading 2.7 8.7 16.9 -4.1 -0.8
Alcohol intake frequency. 0.4 1.0 1.9 -1.4 0.1
Comparative height size at age 10 0.2 1.3 2.4 0.4 1.6
Number of full sisters 0.6 0.7 1.4 1.2 0.2
Suffer from ‘nerves’ 0.3 0.4 0.7 0.9 -0.3
Overall health rating 5.5 11.9 16.9 2.6 -4.1
Chest pain or discomfort 1.4 2.0 3.7 -0.6 1.9
Had major operations 0.1 0.1 0.1 -0.3 -0.4
Age at last live birth 0.4 0.6 0.8 0.9 0.5
Family relationship satisfaction 0.7 0.8 1.2 0.7 -1.1
Leg pain on walking 0.1 0.2 0.2 -0.3 0.5
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.2 0.3 0.5 0.2
Commuting to job workplace: Car/motor vehicle 1.4 1.6 2.2 1.5 -1.0
Illness, injury, bereavement, stress in last 2 years 0.9 1.0 1.5 -0.7 1.2
Medication: Aspirin 1.7 2.3 4.6 -0.2 -2.1
Supplements: Vitamin C 1.0 1.2 1.5 1.2 -0.9
Knee pain experienced in last month 2.4 3.7 6.3 1.1 -2.5
Hypertension (Self-reported) 2.7 7.4 14.1 0.8 -3.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.0 6.0 0.1 -2.4
Illnesses of father: Heart disease 1.7 2.4 3.9 2.0 0.9
Illnesses of siblings: Diabetes 1.0 1.2 2.1 0.6 -1.5
Smoking status: Previous 0.7 1.0 1.3 1.1 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 1.8 -0.8 1.3
Whole body fat-free mass 0.1 0.3 0.3 -0.6 0.5
Leg fat-free mass (right) 0.2 1.3 2.0 -1.4 0.8
Arm fat percentage (left) 1.0 4.1 8.3 -2.9 -0.1
Average weekly red wine intake 1.1 1.6 1.7 1.2 1.3
Handedness (chirality/laterality): Left-handed 1.1 1.4 2.3 1.5 -0.6
Mood swings 1.6 2.9 3.8 1.9 -1.4
Loneliness, isolation 2.4 3.3 3.3 1.8 -1.8
Long-standing illness, disability or infirmity 2.2 3.3 6.5 2.5 -0.4
Ever had bowel cancer screening 1.8 2.1 4.1 0.1 -2.0
Diabetes diagnosed by doctor 0.5 0.8 1.0 0.8 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 3.9 4.1 8.3 -0.1 2.9
Friendships satisfaction 1.1 1.3 1.7 -1.0 1.3
Qualifications: nursing, teaching 1.4 2.2 3.8 -1.9 0.8
Commuting to job workplace: Walk 0.5 0.6 1.0 -1.0 0.3
Eye problems/disorders: Cataract 0.1 0.1 0.2 0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 2.1 3.4 3.4 1.9 1.8
Medication for cholesterol 0.5 0.8 0.9 1.0 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.7 -0.9 -0.4
Back pain experienced in last month 1.3 1.9 2.3 1.2 -1.5
Mineral and other dietary supplements 0.3 0.4 0.8 0.2 0.9
Breast cancer (self-reported) 3.3 3.9 4.2 -2.0 -1.9
Asthma (self-reported) 0.7 1.3 2.5 -0.4 -1.6
Osteoporosis (self-reported) 0.5 0.6 1.1 0.3 -1.0
Osteoarthritis (self-reported) 3.5 4.5 6.9 -1.4 2.6
Medication: Aspirin 2.2 2.8 5.6 0.3 -2.4
Medication: Gliclazide 0.2 0.2 0.4 0.6 0.3
Illnesses of father: None of the above (group 1) 2.1 2.6 3.6 -1.9 1.2
Smoking status: Current 1.5 2.3 2.3 1.5 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.5 0.0 2.3
Whole body water mass 0.0 0.2 0.2 -0.4 0.5
Leg predicted mass (right) 0.3 1.4 2.2 -1.5 0.8
Arm fat mass (left) 0.8 3.4 6.7 -2.6 -0.1
Number of self-reported non-cancer illnesses 6.2 10.8 21.0 0.7 -4.6
Average weekly champagne plus white wine intake 0.6 0.9 1.3 -0.6 1.2
Miserableness 0.4 0.8 1.5 1.2 -0.2
Guilty feelings 1.0 1.5 2.8 0.4 1.7
Wears glasses or contact lenses 0.6 0.7 0.8 -0.8 0.9
Ever taken oral contraceptive pill 1.0 1.1 2.0 1.4 -0.5
Hearing aid user 0.6 0.6 0.8 0.7 -0.9
Mother’s age at death 0.3 0.4 0.7 0.8 0.2
Financial situation satisfaction 0.1 0.1 0.1 0.4 -0.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.5 0.1
Commuting to job workplace: Public transport 3.1 3.7 4.9 -2.2 1.6
Eye problems/disorders: Glaucoma 0.9 1.1 2.2 -0.1 1.5
Medication: Blood pressure 0.6 1.2 2.1 -0.6 -1.4
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.8 0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.6 -0.5 -0.8
High cholesterol (Self-reported) 0.0 0.0 0.0 0.2 0.1
Medication: Bendroflumethiazide 4.7 7.2 14.4 0.1 -3.8
Medication: Paracetamol 0.6 0.9 1.3 -1.1 -0.7
Medication: Lisinopril 0.2 0.2 0.4 -0.2 0.7
Medication: Atorvastatin 0.3 0.4 0.5 -0.7 -0.5
Illnesses of father: High blood pressure 0.2 0.2 0.3 -0.3 -0.5
Alcohol drinker status: Never 2.1 2.5 4.5 -2.1 0.7
Ever smoked 1.4 2.5 4.8 2.2 -0.4
Basal metabolic rate 0.1 0.6 0.9 -1.0 0.5
Leg fat percentage (left) 0.5 1.9 2.8 -1.7 -1.0
Arm fat-free mass (left) 0.0 0.1 0.1 -0.3 -0.3
Number of operations (self-reported) 0.9 1.4 1.4 -1.2 1.2
Average weekly beer plus cider intake 4.2 6.1 7.7 2.8 -2.1
Irritability 0.7 1.2 2.2 0.5 1.5
Risk taking 0.6 0.9 1.7 1.3 -0.3
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.1 -0.5
Fractured/broken bones in last 5 years 2.5 3.2 5.9 -0.7 2.4
Age started oral contraceptive pill 3.5 4.4 8.5 0.5 -2.9
Diastolic blood pressure, automated reading 0.1 0.5 0.7 0.8 0.5
Ever depressed for a whole week 0.8 1.0 1.9 0.1 -1.4
Unable to work because of sickness or disability 0.6 0.8 1.5 0.4 1.2
Commuting to job workplace: Cycle 0.8 0.9 1.4 -1.2 0.7
Myopia 0.3 0.4 0.6 0.5 0.8
Vascular/heart problems diagnosed by doctor 2.3 6.4 12.7 -0.3 3.6
Cholesterol lowering medication 0.8 1.2 2.0 -1.4 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.0 0.1 0.1 0.3 0.0
Pain experienced in last month 1.8 3.0 3.7 -1.6 1.9
Supplements: Calcium 0.7 0.8 1.3 1.1 -0.5
Basal cell carcinoma (self-reported) 0.4 0.5 0.9 -0.2 1.0
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.6 -0.8 0.3
Deep venous thrombosis (DVT) (self-reported) 3.2 4.1 4.8 -1.9 -2.2
Heart disease (siblings) 0.8 0.9 1.8 -1.4 0.2
Alcohol drinker status: Previous 1.3 1.4 2.6 0.5 -1.6
Pack years of smoking 0.4 0.6 0.6 0.8 -0.7
Impedance of whole body 0.9 4.5 7.6 -1.2 2.8
Leg fat mass (left) 0.6 2.4 4.5 -2.1 -0.4
Arm predicted mass (left) 0.0 0.1 0.1 -0.4 -0.2