Hub : Genes

RASL11A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Stomach	0.2490	0.0690	0.00041	0.048	NA	0.127	NA	0.048	2.5e-03	NA	1.2e-06	NA	2.5e-03
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0399	0.0196	0.00027	0.022	0.032	0.028	NA	0.028	1.5e-03	1.3e-04	3.8e-04	NA	3.7e-04
3	TCGA	Brain Lower Grade Glioma	0.0435	0.0185	0.00005	0.037	0.047	0.042	NA	0.039	4.5e-05	4.9e-06	1.5e-05	NA	2.6e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.1	0.1	0.2	0.2	0.4	-0.4
Bipolar Disorder or Schizophrenia	1.3	3.2	5.3	1.9	0.7	-2.3
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	0.2	-0.2	-0.2
Depression (Nagel 2018)	0.9	1.4	2.4	-0.7	1.6	-1.1
Intelligence (Savage-Jansen 2018)	0.9	2.7	5.8	-1.1	2.4	1.1
Neuroticism (Nagel 2018)	0.7	1.7	2.7	1.7	0.7	-1.3
Schizophrenia (2018)	1.9	4.0	6.9	2.2	0.6	-2.6
Schizophrenia vs Biploar Disorder	1.8	2.3	3.6	1.3	-1.9	-1.2
Worry (Nagel 2018)	0.9	1.8	2.4	1.5	1.6	-0.9
Alzheimer’s Disease (in mother)	0.5	0.6	1.0	-0.5	-0.7	1.0
Alzheimer’s Disease (in father)	0.3	0.3	0.6	0.8	0.3	0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.0	-0.0	-1.0	1.0
Crohns Disease (2017)	0.3	0.7	1.3	1.1	0.2	-0.8
Irritable Bowel Disease (IBD)	2.0	4.8	9.7	3.1	0.1	-2.2
Ulcerative Colitis (UC)	3.3	6.2	11.1	3.3	-0.7	-2.7
Major Depression (MDD)	0.7	0.9	1.9	0.4	1.4	-0.8
Reaction Time	0.1	0.2	0.5	-0.1	-0.7	-0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.4	-0.7	0.6	0.2
Breast Cancer	0.4	1.0	1.7	-1.3	-0.4	1.1
Ovarian Cancer	1.9	2.5	4.2	-1.4	2.1	1.2
Prostate Cancer	0.3	0.4	0.9	0.9	0.2	-0.5
Age at First Birth	0.6	0.9	2.2	0.7	1.5	-0.2
Bipolar Disorder (2011)	0.6	0.6	1.1	-0.4	1.0	-0.7
Body Mass Index (BMI) (2010)	2.4	3.3	9.6	-3.1	0.5	0.2
Coronary Artery Disease (CAD)	1.3	1.5	3.6	-0.7	1.9	-0.6
Crohns Disease (2012)	0.2	0.4	1.0	-0.1	1.0	-0.1
Mean Putamen Volume	0.1	0.1	0.3	0.2	-0.5	0.1
Fasting Glucose	0.3	0.3	0.7	0.5	-0.3	0.8
HbA1C	0.1	0.1	0.2	-0.4	0.0	-0.2
HDL Cholesterol	0.6	1.0	1.8	1.3	0.8	-0.7
LDL Cholesterol	1.3	2.0	5.2	0.6	0.7	-2.3
Lupus	0.6	0.9	1.3	-0.8	0.8	1.1
Neuroticism (2016)	0.8	1.1	1.7	1.3	-0.9	-0.9
Primary Biliary Cirrhosis	0.5	0.7	1.7	-0.2	-0.6	1.3
Rheumatoid Arthritis	0.7	1.0	1.4	1.1	0.7	-1.2
Schizophrenia (2014)	0.7	1.5	2.6	1.6	-0.2	-1.3
Triglycerides	0.2	0.3	0.9	-0.9	-0.1	0.3
Type 2 Diabetes (T2D) (2012)	2.0	2.3	6.7	-2.6	0.2	0.3
Ulcerative Colitis	1.6	2.3	3.7	1.7	-0.5	-1.9
Blood Eosinophil Count	0.1	0.4	0.9	-0.9	-0.6	-0.0
Blood Platelet Count	0.2	2.4	5.2	0.2	2.3	-1.4
Blood Red Count	1.5	14.8	21.2	4.6	2.6	-4.0
Blood White Count	1.4	10.6	27.5	1.3	1.6	-5.2
Heel T-Score	0.3	2.3	2.8	1.2	-1.7	-1.6
BMI	0.5	3.1	4.7	-2.2	-2.0	-0.7
Height	0.9	17.9	28.0	-4.9	-1.2	5.3
Waist Hip Ratio (WHR)	0.1	0.3	0.5	-0.6	0.4	-0.7
Systolic Blood Pressure	4.6	23.2	24.6	5.0	4.6	-4.9
Smoking Status	1.8	4.3	10.1	-1.3	-3.2	1.1
Allergy or Eczema	0.1	0.2	0.4	0.2	-0.6	-0.4
Cardiovascular Disease	0.3	1.0	2.3	0.7	0.3	-1.5
Hypothyroidism (self reported)	0.6	1.4	3.2	0.4	0.8	-1.8
Respiratory disease	0.5	1.2	1.7	0.7	-1.3	-1.2
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	-1.2	-0.8	-0.2
Lung FEV1/FVC ratio	1.2	6.2	13.7	-1.2	-3.7	1.9
Lung FVC	0.5	2.4	6.5	0.8	2.5	-0.4
Neuroticism	0.6	1.5	1.7	1.2	1.3	-1.2
Chronotype (morning person)	1.8	4.2	11.0	-1.2	-3.3	0.6
Hair Pigment	0.0	0.6	1.2	-0.1	-0.8	1.1
Tanning	0.1	0.8	1.6	-1.3	-0.7	0.7
Hand grip strength (left)	0.9	2.3	4.4	2.1	-0.4	-1.5
Number of treatments/medications taken	0.6	1.1	1.4	1.1	-0.8	-1.2
Average weekly spirits intake	1.6	2.0	5.7	-0.5	-2.4	0.4
Sensitivity / hurt feelings	0.3	0.6	1.4	0.5	-1.2	-0.2
Frequency of depressed mood in last 2 weeks	1.9	2.6	6.0	0.6	2.5	-1.2
Hearing difficulty/problems: Yes	0.9	1.4	2.2	-1.2	0.6	1.5
Relative age of first facial hair	0.2	0.4	1.0	0.1	0.5	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	-0.4	1.2	-0.2
Ever used hormone-replacement therapy (HRT)	0.8	1.1	2.6	0.5	-0.6	-1.6
Ever had hysterectomy (womb removed)	0.8	0.9	2.5	0.1	0.6	-1.6
Systolic blood pressure, automated reading	4.7	13.7	18.9	4.1	2.3	-4.4
Eye problems/disorders: Diabetes related eye disease	0.0	0.1	0.1	0.1	-0.2	0.3
Angina	0.2	0.3	0.7	-0.4	0.8	-0.3
Medication for hormone replacement therapy	0.3	0.4	0.9	0.9	0.4	0.3
Vitamin and mineral supplements	1.7	2.4	5.8	0.6	1.0	-2.4
Supplements: Zinc	2.3	2.6	6.1	-1.1	-2.5	0.6
Medication: Co-codamol	0.4	0.4	1.2	0.2	-1.1	-0.2
Medication: Metformin	0.9	1.2	2.7	0.2	-1.7	-1.0
Diabetes (father)	0.2	0.3	0.7	0.4	-0.9	-0.1
Diabetes (mother)	0.5	0.6	1.2	0.8	0.0	-1.1
Severe depression (siblings)	2.8	3.1	6.3	2.5	0.9	-1.4
Pack years adult smoking proportion	0.4	0.6	1.3	-0.7	1.1	0.4
Impedance of leg (right)	0.2	1.0	1.7	1.1	-0.2	-1.3
Leg fat-free mass (left)	0.8	4.0	7.1	-2.7	-0.6	2.2
Trunk fat percentage	0.4	1.5	2.7	-1.7	-1.4	0.1
Hand grip strength (right)	0.8	2.1	4.5	2.1	0.0	-1.3
Townsend deprivation index at recruitment	0.6	0.9	2.0	-1.4	-0.8	0.3
Current tobacco smoking	0.2	0.3	0.9	-0.9	0.1	-0.1
Average weekly fortified wine intake	0.8	1.0	1.9	-0.9	-1.4	-0.5
Maternal smoking around birth	0.4	0.5	1.2	1.1	0.5	-0.4
Fed-up feelings	0.1	0.1	0.2	-0.1	0.4	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	1.8	-1.3	1.4	-0.4
Relative age voice broke	0.2	0.3	0.5	-0.0	-0.7	-0.6
Taking other prescription medications	1.2	1.8	3.5	0.9	-1.9	-1.0
Age when periods started (menarche)	0.4	0.9	1.4	-0.5	1.2	1.0
Bilateral oophorectomy (both ovaries removed)	3.1	3.6	8.6	2.9	0.7	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	2.7	-1.6	0.3	1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.2	-0.4	0.5	0.4
Qualifications: CSEs or equivalent	1.0	1.4	3.8	-2.0	-0.5	0.2
Serious illness, injury or assault to yourself	0.3	0.4	0.6	-0.2	0.8	-0.8
High blood pressure	1.0	2.8	4.0	2.0	0.6	-2.0
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.0	1.0	0.2	-0.1
Multivitamins +/- minerals	1.5	1.9	4.5	-1.0	-0.6	2.1
Stomach or abdominal pain in last month	1.3	1.6	2.8	-1.7	-1.2	-0.8
Supplements: Glucosamine	0.5	0.6	0.9	-0.5	0.9	1.0
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	2.5	1.5	0.9	-1.6
Medication: Atenolol	0.6	0.7	1.7	1.3	0.5	-0.4
Medication: Levothyroxine sodium	0.6	1.0	2.5	0.4	-0.5	-1.6
Sitting height	0.7	5.3	9.4	-1.7	1.9	3.1
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	0.1	0.2	0.3
High blood pressure (mother)	0.1	0.2	0.3	0.4	-0.6	0.1
Body mass index (BMI)	0.5	2.2	4.7	-1.4	-2.2	-0.3
Impedance of leg (left)	0.2	1.1	2.2	1.0	0.1	-1.5
Leg predicted mass (left)	0.8	4.0	6.7	-2.6	-0.7	2.2
Trunk fat mass	0.7	2.8	5.4	-2.3	-1.6	0.7
Waist circumference	1.3	4.8	9.5	-3.1	-2.1	0.7
Number of incorrect matches in round	0.4	0.6	1.1	1.0	0.7	-0.7
Past tobacco smoking	3.7	6.8	20.2	-0.0	4.5	0.6
Alcohol usually taken with meals	0.4	0.7	1.1	-0.5	-1.0	-0.8
Nervous feelings	0.3	0.6	1.3	0.4	0.7	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.2	-0.2	1.1	-1.5
Hearing difficulty/problems with background noise	0.4	0.7	1.2	-0.5	1.1	0.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.1	-1.4	-0.6	-0.7
Had menopause	0.1	0.1	0.3	0.1	-0.2	-0.6
Had other major operations	0.7	0.8	1.2	0.6	-0.9	-1.1
Forced vital capacity (FVC)	1.0	3.9	10.4	-1.1	3.2	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.7	-1.9	0.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	-0.7	-0.6	0.3
Qualifications: None of the above	1.0	2.2	6.1	0.5	-2.5	0.4
Financial difficulties in last 2 years	0.8	1.0	1.5	1.2	-0.8	-1.0
Mouth/teeth dental problems	0.4	0.6	1.1	-0.1	-1.1	0.7
Heart attack	0.7	0.9	2.6	-0.2	-1.6	-0.1
Allergy	0.1	0.2	0.5	-0.7	-0.1	-0.1
Pain all over the body in last month	1.5	1.6	3.9	0.4	-2.0	0.8
Diabetes (self-reported)	0.8	1.3	3.5	-0.4	-1.9	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.3	0.0	-0.0	-0.6
Medication: Ramipril	0.7	0.9	1.5	-0.0	-1.1	-1.2
Medication: Simvastatin	1.0	1.4	3.6	0.8	-1.9	-0.0
Fluid intelligence score	1.1	2.3	5.5	0.8	2.3	-0.9
Illnesses of siblings	0.1	0.2	0.5	-0.1	0.1	0.7
Neuroticism score	0.0	0.0	0.0	0.2	0.2	-0.1
Weight	0.8	3.9	7.8	-2.8	-1.6	1.1
Impedance of arm (right)	0.2	0.9	2.0	0.5	1.4	0.7
Arm fat percentage (right)	0.5	2.0	4.6	-1.1	-2.1	0.5
Trunk fat-free mass	1.0	5.7	9.4	-3.1	-1.4	2.4
Hip circumference	0.9	3.7	7.2	-2.7	-1.5	1.2
Time employed in main current job	1.8	2.1	4.4	-1.3	2.1	0.3
Alcohol intake versus 10 years previously	0.5	0.7	1.4	0.3	-0.8	-1.2
Father’s age at death	1.3	1.8	3.6	1.9	0.8	-1.1
Worrier / anxious feelings	1.2	2.2	5.3	2.3	0.8	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.2	4.8	-2.2	0.1	1.4
Falls in the last year	1.4	1.9	4.3	-0.9	-0.9	2.1
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	1.3	0.6	-0.4
Number of live births	1.7	2.4	4.1	-0.9	2.0	1.5
Forced expiratory volume in 1-second (FEV1)	0.8	2.6	6.4	-1.0	2.5	0.5
Pulse rate	1.4	2.3	6.9	-2.6	0.3	0.1
Happiness	0.5	0.6	1.4	-0.4	0.5	-1.2
Noisy workplace	0.6	0.7	1.2	0.6	-0.7	-1.1
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.9	0.3	1.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	2.3	-1.5	1.4	-0.2
Mouth/teeth dental problems: Dentures	0.7	1.2	2.9	-0.6	0.5	-1.7
Asthma	0.3	0.5	1.0	1.0	-0.1	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.1	-0.2	1.0	-1.0
Medication: Cholesterol lowering	0.1	0.1	0.3	-0.2	-0.6	0.0
Depression (self-reported)	0.1	0.1	0.4	-0.1	0.2	-0.6
Medication: Lansoprazole	0.3	0.3	0.9	-0.0	0.9	0.1
Prospective memory result	0.7	0.9	1.0	-0.9	-0.9	1.0
Lung cancer (father)	0.4	0.5	0.9	-0.7	-0.2	0.9
Illnesses of mother	0.5	0.6	1.4	-0.7	1.2	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.1	1.5	-1.2	1.0	0.9
Pulse wave Arterial Stiffness index	0.9	1.1	1.8	-0.9	-0.8	1.3
Impedance of arm (left)	0.4	1.8	4.3	1.0	2.1	-0.4
Arm fat mass (right)	0.6	2.5	3.6	-1.9	-1.9	0.6
Trunk predicted mass	1.0	5.8	9.7	-3.1	-1.4	2.4
Standing height	0.6	5.9	10.0	-3.2	0.7	2.7
Length of working week for main job	2.7	3.0	4.6	-0.0	-2.1	-2.2
Exposure to tobacco smoke at home	0.3	0.4	0.5	0.7	-0.7	-0.3
Breastfed as a baby	0.1	0.1	0.2	0.3	0.4	-0.3
Tense / ‘highly strung’	0.2	0.4	0.5	0.7	0.7	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.6	-0.6	-0.2
Hair/balding pattern: Pattern 4	0.8	1.9	5.2	-0.8	-0.2	2.3
Birth weight of first child	2.2	4.0	7.6	-2.1	0.2	2.8
Peak expiratory flow (PEF)	0.5	1.3	3.4	0.3	1.8	0.5
Pulse wave reflection index	0.4	0.5	0.9	0.2	-1.0	0.7
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.8	0.8	-1.4	-0.2
Loud music exposure frequency	0.7	0.7	1.1	0.0	1.1	1.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	3.4	-0.7	1.8	0.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.3	5.3	0.7	2.3	-1.0
Blood clot in the leg (DVT)	2.4	3.1	5.1	-1.6	1.2	2.3
Medication: Paracetamol	2.2	3.6	6.0	-2.1	-2.4	0.5
Headache pain in last month	1.8	3.0	4.6	-2.0	-2.1	0.7
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.2	-0.0	-0.2	-0.5
Glaucoma (self-reported)	1.0	1.2	2.4	0.2	1.5	-1.0
Gout (self-reported)	2.3	3.1	4.6	1.0	2.0	-2.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	2.6	-0.5	-0.1	-1.6
Medication: Amlodipine	1.0	1.4	2.0	1.4	-0.6	-1.4
Medication: Ventolin 100micrograms inhaler	0.4	0.5	0.9	1.0	-0.3	-0.6
Birth weight	0.1	0.3	0.8	0.0	0.9	0.2
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.6	0.8	-0.1	0.4
High blood pressure (siblings)	0.7	0.9	2.0	1.4	0.5	-0.8
Forced vital capacity (FVC), Best measure	0.6	2.1	4.6	-1.1	2.1	0.7
Body fat percentage	0.4	1.7	3.2	-1.4	-1.8	-0.2
Leg fat percentage (right)	0.6	2.0	4.9	-0.7	-2.2	-0.8
Arm fat-free mass (right)	0.6	3.1	6.4	-2.5	-1.2	1.2
Exposure to tobacco smoke outside home	2.8	3.7	7.7	-0.2	-2.8	1.8
Comparative body size at age 10	0.3	0.9	1.5	-0.0	1.2	-1.0
Number of full brothers	0.6	0.8	1.7	-0.9	-0.0	1.3
Worry too long after embarrassment	1.5	2.5	5.3	0.8	2.3	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	-0.6	-0.4	0.1
Wheeze or whistling in the chest in last year	0.5	0.9	1.6	1.3	1.1	-0.2
Number of children fathered	0.7	0.7	1.9	1.4	0.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.1	1.0	-0.1	-0.4
Age at first live birth	0.6	1.0	1.5	-0.5	1.1	1.2
Pulse wave peak to peak time	0.4	0.5	0.7	0.6	0.6	-0.9
Health satisfaction	1.2	1.5	4.4	-2.1	-0.4	0.1
Shortness of breath walking on level ground	0.3	0.3	0.9	0.2	-0.9	-0.0
Qualifications: College or University degree	0.4	1.3	2.0	0.8	1.4	1.2
Eye problems/disorders: None of the above	1.3	1.5	2.4	0.3	-1.4	1.5
Mouth/teeth dental problems: Loose teeth	1.2	1.4	2.2	1.4	-0.4	-1.5
Emphysema/chronic bronchitis	0.3	0.3	0.5	0.6	-0.3	-0.7
Medication for pain relief, constipation, heartburn	0.8	1.3	2.8	0.6	1.7	0.9
Neck or shoulder pain in last month	1.3	1.8	4.8	-0.3	-2.2	-0.7
Medication: Blood pressure	0.2	0.3	0.6	0.4	0.8	-0.2
Angina (self-reported)	0.2	0.3	0.4	-0.4	0.7	-0.5
Migraine (self-reported)	1.8	2.3	5.9	-0.1	-1.0	2.4
Medication: Ibuprofen	0.3	0.3	0.5	-0.2	0.7	-0.7
Medication: Allopurinol	0.8	1.1	2.0	-0.7	0.8	-1.4
Medication: Omeprazole	1.4	1.7	2.2	-1.0	-1.5	1.4
Medication: Seretide 50 evohaler	0.1	0.1	0.3	-0.1	-0.3	0.5
Mean time to correctly identify matches	0.1	0.3	0.6	-0.4	-0.8	0.2
Heart disease (mother)	0.3	0.3	0.4	0.6	0.4	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.1	0.1	0.2	0.1	0.3
Whole body fat mass	0.6	2.4	3.8	-1.9	-1.8	0.5
Leg fat mass (right)	0.7	2.6	5.1	-1.6	-2.2	-0.1
Arm predicted mass (right)	0.8	3.8	8.0	-2.8	-1.4	1.3
Pulse rate, automated reading	0.8	2.5	5.5	-2.3	0.6	1.3
Alcohol intake frequency.	0.5	1.3	2.0	1.2	0.4	-1.4
Comparative height size at age 10	1.1	5.9	11.7	-3.4	0.3	2.4
Number of full sisters	0.6	0.7	1.4	-1.2	0.9	0.1
Suffer from ‘nerves’	0.4	0.6	1.6	0.1	1.3	0.3
Overall health rating	0.2	0.5	1.0	-0.4	-0.6	1.0
Chest pain or discomfort	0.0	0.1	0.2	0.2	0.1	-0.4
Had major operations	0.2	0.2	0.7	-0.8	0.1	-0.1
Age at last live birth	1.3	1.9	3.5	-1.9	1.0	1.1
Family relationship satisfaction	0.3	0.4	0.6	-0.4	0.8	-0.5
Leg pain on walking	0.7	0.9	2.5	-0.0	-1.6	0.5
Qualifications: NVQ or HND or HNC or equivalent	3.2	3.8	6.9	2.6	0.2	-2.1
Commuting to job workplace: Car/motor vehicle	1.5	1.8	5.0	0.0	0.6	2.2
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	1.4	1.2	-1.0	-1.1
Medication: Aspirin	0.2	0.3	0.7	0.8	-0.3	-0.1
Supplements: Vitamin C	0.6	0.8	1.3	0.9	0.4	1.2
Knee pain experienced in last month	0.4	0.7	2.0	-1.4	0.0	0.3
Hypertension (Self-reported)	1.2	3.3	5.0	2.2	0.7	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	2.1	0.3	0.5	1.4
Illnesses of father: Heart disease	0.4	0.6	1.4	-1.2	-0.1	0.6
Illnesses of siblings: Diabetes	0.8	1.0	1.9	-1.4	-1.0	-0.2
Smoking status: Previous	3.8	5.6	16.7	-0.2	-4.1	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.0	-1.7	-0.4	1.3
Whole body fat-free mass	1.0	5.4	9.3	-3.0	-1.2	2.4
Leg fat-free mass (right)	0.7	3.7	6.6	-2.6	-0.1	2.1
Arm fat percentage (left)	0.3	1.2	2.5	-1.0	-1.6	0.0
Average weekly red wine intake	2.1	3.2	4.9	2.2	-1.7	-1.3
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.2	1.5	1.8	-0.7
Mood swings	0.0	0.0	0.1	-0.2	0.1	-0.0
Loneliness, isolation	0.3	0.4	0.5	-0.5	-0.7	0.7
Long-standing illness, disability or infirmity	0.3	0.4	1.1	-1.1	-0.3	-0.2
Ever had bowel cancer screening	0.4	0.4	1.1	-0.4	1.1	-0.1
Diabetes diagnosed by doctor	0.5	0.8	2.4	-0.4	-1.5	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.1	-0.1	0.1	0.2
Friendships satisfaction	0.4	0.5	0.9	0.7	0.9	0.4
Qualifications: nursing, teaching	0.4	0.6	1.3	1.1	-0.2	0.8
Commuting to job workplace: Walk	2.1	2.2	6.2	0.6	-0.3	-2.5
Eye problems/disorders: Cataract	0.6	0.7	1.4	-0.1	1.2	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	2.0	0.9	-0.9	1.4
Medication for cholesterol	1.5	2.3	3.0	-1.7	1.2	1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.0	-1.7	-0.3	0.1
Back pain experienced in last month	1.0	1.5	2.9	-1.7	-1.1	0.7
Mineral and other dietary supplements	0.2	0.2	0.4	-0.0	0.7	-0.5
Breast cancer (self-reported)	0.3	0.4	0.8	0.4	-0.9	-0.3
Asthma (self-reported)	0.4	0.8	1.3	1.1	-0.2	-1.1
Osteoporosis (self-reported)	0.8	1.0	2.6	0.5	-1.6	-0.3
Osteoarthritis (self-reported)	1.3	1.7	2.8	-1.5	-1.7	-0.0
Medication: Aspirin	0.5	0.7	1.7	1.3	-0.2	-0.5
Medication: Gliclazide	1.2	1.4	3.8	-0.5	-1.9	0.4
Illnesses of father: None of the above (group 1)	1.2	1.5	2.4	-1.6	-0.7	1.3
Smoking status: Current	0.1	0.2	0.5	-0.7	-0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.3	1.0	1.5	-0.3
Whole body water mass	0.9	5.2	9.0	-3.0	-1.2	2.2
Leg predicted mass (right)	0.7	3.6	6.3	-2.5	-0.2	2.1
Arm fat mass (left)	0.6	2.6	4.2	-2.1	-1.9	0.5
Number of self-reported non-cancer illnesses	0.4	0.7	0.9	0.8	-0.7	-0.9
Average weekly champagne plus white wine intake	0.6	0.9	1.8	-1.3	-0.6	0.7
Miserableness	0.7	1.2	1.5	1.2	1.2	-0.8
Guilty feelings	0.8	1.1	2.6	0.7	0.6	-1.6
Wears glasses or contact lenses	0.9	1.0	2.4	0.7	-0.1	1.6
Ever taken oral contraceptive pill	0.3	0.3	0.9	0.1	0.2	-0.9
Hearing aid user	0.3	0.3	0.6	-0.6	0.2	-0.8
Mother’s age at death	2.3	2.9	5.2	-1.8	0.2	2.3
Financial situation satisfaction	0.0	0.0	0.1	-0.1	0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.8	-0.5	-1.3	-0.4
Commuting to job workplace: Public transport	1.1	1.3	2.4	1.2	0.1	-1.5
Eye problems/disorders: Glaucoma	0.9	1.0	2.8	0.2	1.7	-0.6
Medication: Blood pressure	2.2	4.2	6.9	2.6	-0.4	-2.3
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.7	0.7	-0.8	-2.2
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.0	0.4	-1.0	-0.7
High cholesterol (Self-reported)	1.3	2.3	3.9	2.0	-0.8	-1.5
Medication: Bendroflumethiazide	1.5	2.3	4.4	0.8	1.3	-2.1
Medication: Paracetamol	1.4	2.1	3.7	-1.6	-1.9	-0.4
Medication: Lisinopril	0.3	0.4	0.8	0.3	0.9	-0.6
Medication: Atorvastatin	0.4	0.5	0.9	0.7	-0.3	-1.0
Illnesses of father: High blood pressure	0.5	0.6	1.5	0.3	0.5	-1.2
Alcohol drinker status: Never	3.4	4.0	12.0	3.5	0.3	0.1
Ever smoked	1.2	2.0	5.4	-0.5	-2.3	-0.7
Basal metabolic rate	0.9	4.9	9.1	-3.0	-1.2	2.0
Leg fat percentage (left)	0.5	1.7	3.9	-0.7	-2.0	-0.8
Arm fat-free mass (left)	1.0	4.9	8.4	-2.9	-1.9	1.6
Number of operations (self-reported)	0.2	0.3	0.4	0.4	0.7	-0.6
Average weekly beer plus cider intake	0.4	0.5	1.5	0.2	-0.0	-1.2
Irritability	0.3	0.4	1.1	0.2	-1.1	0.4
Risk taking	1.4	2.1	5.9	-2.4	0.0	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	0.8	0.9	-0.2	-0.2
Fractured/broken bones in last 5 years	0.5	0.6	1.7	0.3	0.1	1.3
Age started oral contraceptive pill	1.2	1.5	3.0	-0.5	-1.7	-1.1
Diastolic blood pressure, automated reading	2.4	7.3	10.6	2.2	2.5	-3.3
Ever depressed for a whole week	0.0	0.1	0.1	-0.2	-0.2	-0.2
Unable to work because of sickness or disability	0.2	0.3	0.5	0.7	-0.2	0.6
Commuting to job workplace: Cycle	1.6	2.0	3.1	-1.1	-1.8	-1.3
Myopia	0.7	1.0	1.5	-1.1	1.2	0.3
Vascular/heart problems diagnosed by doctor	0.9	2.4	3.7	-1.9	-0.3	1.9
Cholesterol lowering medication	3.5	5.2	6.5	2.2	-2.5	-2.0
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.5	-0.5	-0.8	1.2
Pain experienced in last month	0.7	1.2	2.4	1.1	1.6	-0.1
Supplements: Calcium	0.5	0.5	1.5	0.3	-1.2	0.2
Basal cell carcinoma (self-reported)	0.5	0.6	1.1	0.1	-1.1	0.8
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.1	-0.2	-1.5	0.1
Deep venous thrombosis (DVT) (self-reported)	2.2	2.9	5.7	-1.4	1.0	2.4
Heart disease (siblings)	0.3	0.3	0.5	-0.3	-0.7	-0.6
Alcohol drinker status: Previous	0.4	0.5	0.8	-0.9	-0.5	-0.6
Pack years of smoking	0.2	0.3	0.8	-0.1	0.9	0.4
Impedance of whole body	0.2	1.1	1.5	1.0	1.2	-0.9
Leg fat mass (left)	0.6	2.4	4.5	-1.7	-2.1	-0.0
Arm predicted mass (left)	1.0	5.0	8.5	-2.9	-1.8	1.8