Hub : Genes

RASL11A

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Stomach 0.2490 0.0690 0.00041 0.048 NA 0.127 NA 0.048 2.5e-03 NA 1.2e-06 NA 2.5e-03
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0399 0.0196 0.00027 0.022 0.032 0.028 NA 0.028 1.5e-03 1.3e-04 3.8e-04 NA 3.7e-04
3 TCGA Brain Lower Grade Glioma 0.0435 0.0185 0.00005 0.037 0.047 0.042 NA 0.039 4.5e-05 4.9e-06 1.5e-05 NA 2.6e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.1 0.2 0.2 0.4 -0.4
Bipolar Disorder or Schizophrenia 1.3 3.2 5.3 1.9 0.7 -2.3
Depressed Affect (Nagel 2018) 0.0 0.0 0.1 0.2 -0.2 -0.2
Depression (Nagel 2018) 0.9 1.4 2.4 -0.7 1.6 -1.1
Intelligence (Savage-Jansen 2018) 0.9 2.7 5.8 -1.1 2.4 1.1
Neuroticism (Nagel 2018) 0.7 1.7 2.7 1.7 0.7 -1.3
Schizophrenia (2018) 1.9 4.0 6.9 2.2 0.6 -2.6
Schizophrenia vs Biploar Disorder 1.8 2.3 3.6 1.3 -1.9 -1.2
Worry (Nagel 2018) 0.9 1.8 2.4 1.5 1.6 -0.9
Alzheimer’s Disease (in mother) 0.5 0.6 1.0 -0.5 -0.7 1.0
Alzheimer’s Disease (in father) 0.3 0.3 0.6 0.8 0.3 0.4
Alzheimer’s Disease (including proxy) 0.5 0.7 1.0 -0.0 -1.0 1.0
Crohns Disease (2017) 0.3 0.7 1.3 1.1 0.2 -0.8
Irritable Bowel Disease (IBD) 2.0 4.8 9.7 3.1 0.1 -2.2
Ulcerative Colitis (UC) 3.3 6.2 11.1 3.3 -0.7 -2.7
Major Depression (MDD) 0.7 0.9 1.9 0.4 1.4 -0.8
Reaction Time 0.1 0.2 0.5 -0.1 -0.7 -0.0
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.4 -0.7 0.6 0.2
Breast Cancer 0.4 1.0 1.7 -1.3 -0.4 1.1
Ovarian Cancer 1.9 2.5 4.2 -1.4 2.1 1.2
Prostate Cancer 0.3 0.4 0.9 0.9 0.2 -0.5
Age at First Birth 0.6 0.9 2.2 0.7 1.5 -0.2
Bipolar Disorder (2011) 0.6 0.6 1.1 -0.4 1.0 -0.7
Body Mass Index (BMI) (2010) 2.4 3.3 9.6 -3.1 0.5 0.2
Coronary Artery Disease (CAD) 1.3 1.5 3.6 -0.7 1.9 -0.6
Crohns Disease (2012) 0.2 0.4 1.0 -0.1 1.0 -0.1
Mean Putamen Volume 0.1 0.1 0.3 0.2 -0.5 0.1
Fasting Glucose 0.3 0.3 0.7 0.5 -0.3 0.8
HbA1C 0.1 0.1 0.2 -0.4 0.0 -0.2
HDL Cholesterol 0.6 1.0 1.8 1.3 0.8 -0.7
LDL Cholesterol 1.3 2.0 5.2 0.6 0.7 -2.3
Lupus 0.6 0.9 1.3 -0.8 0.8 1.1
Neuroticism (2016) 0.8 1.1 1.7 1.3 -0.9 -0.9
Primary Biliary Cirrhosis 0.5 0.7 1.7 -0.2 -0.6 1.3
Rheumatoid Arthritis 0.7 1.0 1.4 1.1 0.7 -1.2
Schizophrenia (2014) 0.7 1.5 2.6 1.6 -0.2 -1.3
Triglycerides 0.2 0.3 0.9 -0.9 -0.1 0.3
Type 2 Diabetes (T2D) (2012) 2.0 2.3 6.7 -2.6 0.2 0.3
Ulcerative Colitis 1.6 2.3 3.7 1.7 -0.5 -1.9
Blood Eosinophil Count 0.1 0.4 0.9 -0.9 -0.6 -0.0
Blood Platelet Count 0.2 2.4 5.2 0.2 2.3 -1.4
Blood Red Count 1.5 14.8 21.2 4.6 2.6 -4.0
Blood White Count 1.4 10.6 27.5 1.3 1.6 -5.2
Heel T-Score 0.3 2.3 2.8 1.2 -1.7 -1.6
BMI 0.5 3.1 4.7 -2.2 -2.0 -0.7
Height 0.9 17.9 28.0 -4.9 -1.2 5.3
Waist Hip Ratio (WHR) 0.1 0.3 0.5 -0.6 0.4 -0.7
Systolic Blood Pressure 4.6 23.2 24.6 5.0 4.6 -4.9
Smoking Status 1.8 4.3 10.1 -1.3 -3.2 1.1
Allergy or Eczema 0.1 0.2 0.4 0.2 -0.6 -0.4
Cardiovascular Disease 0.3 1.0 2.3 0.7 0.3 -1.5
Hypothyroidism (self reported) 0.6 1.4 3.2 0.4 0.8 -1.8
Respiratory disease 0.5 1.2 1.7 0.7 -1.3 -1.2
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.4 -1.2 -0.8 -0.2
Lung FEV1/FVC ratio 1.2 6.2 13.7 -1.2 -3.7 1.9
Lung FVC 0.5 2.4 6.5 0.8 2.5 -0.4
Neuroticism 0.6 1.5 1.7 1.2 1.3 -1.2
Chronotype (morning person) 1.8 4.2 11.0 -1.2 -3.3 0.6
Hair Pigment 0.0 0.6 1.2 -0.1 -0.8 1.1
Tanning 0.1 0.8 1.6 -1.3 -0.7 0.7
Hand grip strength (left) 0.9 2.3 4.4 2.1 -0.4 -1.5
Number of treatments/medications taken 0.6 1.1 1.4 1.1 -0.8 -1.2
Average weekly spirits intake 1.6 2.0 5.7 -0.5 -2.4 0.4
Sensitivity / hurt feelings 0.3 0.6 1.4 0.5 -1.2 -0.2
Frequency of depressed mood in last 2 weeks 1.9 2.6 6.0 0.6 2.5 -1.2
Hearing difficulty/problems: Yes 0.9 1.4 2.2 -1.2 0.6 1.5
Relative age of first facial hair 0.2 0.4 1.0 0.1 0.5 -1.0
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.4 -0.4 1.2 -0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.1 2.6 0.5 -0.6 -1.6
Ever had hysterectomy (womb removed) 0.8 0.9 2.5 0.1 0.6 -1.6
Systolic blood pressure, automated reading 4.7 13.7 18.9 4.1 2.3 -4.4
Eye problems/disorders: Diabetes related eye disease 0.0 0.1 0.1 0.1 -0.2 0.3
Angina 0.2 0.3 0.7 -0.4 0.8 -0.3
Medication for hormone replacement therapy 0.3 0.4 0.9 0.9 0.4 0.3
Vitamin and mineral supplements 1.7 2.4 5.8 0.6 1.0 -2.4
Supplements: Zinc 2.3 2.6 6.1 -1.1 -2.5 0.6
Medication: Co-codamol 0.4 0.4 1.2 0.2 -1.1 -0.2
Medication: Metformin 0.9 1.2 2.7 0.2 -1.7 -1.0
Diabetes (father) 0.2 0.3 0.7 0.4 -0.9 -0.1
Diabetes (mother) 0.5 0.6 1.2 0.8 0.0 -1.1
Severe depression (siblings) 2.8 3.1 6.3 2.5 0.9 -1.4
Pack years adult smoking proportion 0.4 0.6 1.3 -0.7 1.1 0.4
Impedance of leg (right) 0.2 1.0 1.7 1.1 -0.2 -1.3
Leg fat-free mass (left) 0.8 4.0 7.1 -2.7 -0.6 2.2
Trunk fat percentage 0.4 1.5 2.7 -1.7 -1.4 0.1
Hand grip strength (right) 0.8 2.1 4.5 2.1 0.0 -1.3
Townsend deprivation index at recruitment 0.6 0.9 2.0 -1.4 -0.8 0.3
Current tobacco smoking 0.2 0.3 0.9 -0.9 0.1 -0.1
Average weekly fortified wine intake 0.8 1.0 1.9 -0.9 -1.4 -0.5
Maternal smoking around birth 0.4 0.5 1.2 1.1 0.5 -0.4
Fed-up feelings 0.1 0.1 0.2 -0.1 0.4 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.3 1.8 -1.3 1.4 -0.4
Relative age voice broke 0.2 0.3 0.5 -0.0 -0.7 -0.6
Taking other prescription medications 1.2 1.8 3.5 0.9 -1.9 -1.0
Age when periods started (menarche) 0.4 0.9 1.4 -0.5 1.2 1.0
Bilateral oophorectomy (both ovaries removed) 3.1 3.6 8.6 2.9 0.7 -1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 2.7 -1.6 0.3 1.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.2 -0.4 0.5 0.4
Qualifications: CSEs or equivalent 1.0 1.4 3.8 -2.0 -0.5 0.2
Serious illness, injury or assault to yourself 0.3 0.4 0.6 -0.2 0.8 -0.8
High blood pressure 1.0 2.8 4.0 2.0 0.6 -2.0
Hayfever, allergic rhinitis or eczema 0.2 0.4 1.0 1.0 0.2 -0.1
Multivitamins +/- minerals 1.5 1.9 4.5 -1.0 -0.6 2.1
Stomach or abdominal pain in last month 1.3 1.6 2.8 -1.7 -1.2 -0.8
Supplements: Glucosamine 0.5 0.6 0.9 -0.5 0.9 1.0
Diverticular disease/diverticulitis (self-reported) 1.6 1.9 2.5 1.5 0.9 -1.6
Medication: Atenolol 0.6 0.7 1.7 1.3 0.5 -0.4
Medication: Levothyroxine sodium 0.6 1.0 2.5 0.4 -0.5 -1.6
Sitting height 0.7 5.3 9.4 -1.7 1.9 3.1
Chronic bronchitis/emphysema (father) 0.0 0.1 0.1 0.1 0.2 0.3
High blood pressure (mother) 0.1 0.2 0.3 0.4 -0.6 0.1
Body mass index (BMI) 0.5 2.2 4.7 -1.4 -2.2 -0.3
Impedance of leg (left) 0.2 1.1 2.2 1.0 0.1 -1.5
Leg predicted mass (left) 0.8 4.0 6.7 -2.6 -0.7 2.2
Trunk fat mass 0.7 2.8 5.4 -2.3 -1.6 0.7
Waist circumference 1.3 4.8 9.5 -3.1 -2.1 0.7
Number of incorrect matches in round 0.4 0.6 1.1 1.0 0.7 -0.7
Past tobacco smoking 3.7 6.8 20.2 -0.0 4.5 0.6
Alcohol usually taken with meals 0.4 0.7 1.1 -0.5 -1.0 -0.8
Nervous feelings 0.3 0.6 1.3 0.4 0.7 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.2 2.2 -0.2 1.1 -1.5
Hearing difficulty/problems with background noise 0.4 0.7 1.2 -0.5 1.1 0.7
Hair/balding pattern: Pattern 2 0.8 1.0 2.1 -1.4 -0.6 -0.7
Had menopause 0.1 0.1 0.3 0.1 -0.2 -0.6
Had other major operations 0.7 0.8 1.2 0.6 -0.9 -1.1
Forced vital capacity (FVC) 1.0 3.9 10.4 -1.1 3.2 -0.0
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 3.7 -1.9 0.5 0.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.5 -0.7 -0.6 0.3
Qualifications: None of the above 1.0 2.2 6.1 0.5 -2.5 0.4
Financial difficulties in last 2 years 0.8 1.0 1.5 1.2 -0.8 -1.0
Mouth/teeth dental problems 0.4 0.6 1.1 -0.1 -1.1 0.7
Heart attack 0.7 0.9 2.6 -0.2 -1.6 -0.1
Allergy 0.1 0.2 0.5 -0.7 -0.1 -0.1
Pain all over the body in last month 1.5 1.6 3.9 0.4 -2.0 0.8
Diabetes (self-reported) 0.8 1.3 3.5 -0.4 -1.9 -0.4
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.3 0.0 -0.0 -0.6
Medication: Ramipril 0.7 0.9 1.5 -0.0 -1.1 -1.2
Medication: Simvastatin 1.0 1.4 3.6 0.8 -1.9 -0.0
Fluid intelligence score 1.1 2.3 5.5 0.8 2.3 -0.9
Illnesses of siblings 0.1 0.2 0.5 -0.1 0.1 0.7
Neuroticism score 0.0 0.0 0.0 0.2 0.2 -0.1
Weight 0.8 3.9 7.8 -2.8 -1.6 1.1
Impedance of arm (right) 0.2 0.9 2.0 0.5 1.4 0.7
Arm fat percentage (right) 0.5 2.0 4.6 -1.1 -2.1 0.5
Trunk fat-free mass 1.0 5.7 9.4 -3.1 -1.4 2.4
Hip circumference 0.9 3.7 7.2 -2.7 -1.5 1.2
Time employed in main current job 1.8 2.1 4.4 -1.3 2.1 0.3
Alcohol intake versus 10 years previously 0.5 0.7 1.4 0.3 -0.8 -1.2
Father’s age at death 1.3 1.8 3.6 1.9 0.8 -1.1
Worrier / anxious feelings 1.2 2.2 5.3 2.3 0.8 -0.8
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.2 4.8 -2.2 0.1 1.4
Falls in the last year 1.4 1.9 4.3 -0.9 -0.9 2.1
Hair/balding pattern: Pattern 3 0.5 0.8 1.8 1.3 0.6 -0.4
Number of live births 1.7 2.4 4.1 -0.9 2.0 1.5
Forced expiratory volume in 1-second (FEV1) 0.8 2.6 6.4 -1.0 2.5 0.5
Pulse rate 1.4 2.3 6.9 -2.6 0.3 0.1
Happiness 0.5 0.6 1.4 -0.4 0.5 -1.2
Noisy workplace 0.6 0.7 1.2 0.6 -0.7 -1.1
Qualifications: A levels/AS levels or equivalent 0.4 1.0 2.9 0.3 1.7 -0.1
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 2.3 -1.5 1.4 -0.2
Mouth/teeth dental problems: Dentures 0.7 1.2 2.9 -0.6 0.5 -1.7
Asthma 0.3 0.5 1.0 1.0 -0.1 -0.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.1 -0.2 1.0 -1.0
Medication: Cholesterol lowering 0.1 0.1 0.3 -0.2 -0.6 0.0
Depression (self-reported) 0.1 0.1 0.4 -0.1 0.2 -0.6
Medication: Lansoprazole 0.3 0.3 0.9 -0.0 0.9 0.1
Prospective memory result 0.7 0.9 1.0 -0.9 -0.9 1.0
Lung cancer (father) 0.4 0.5 0.9 -0.7 -0.2 0.9
Illnesses of mother 0.5 0.6 1.4 -0.7 1.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.1 1.5 -1.2 1.0 0.9
Pulse wave Arterial Stiffness index 0.9 1.1 1.8 -0.9 -0.8 1.3
Impedance of arm (left) 0.4 1.8 4.3 1.0 2.1 -0.4
Arm fat mass (right) 0.6 2.5 3.6 -1.9 -1.9 0.6
Trunk predicted mass 1.0 5.8 9.7 -3.1 -1.4 2.4
Standing height 0.6 5.9 10.0 -3.2 0.7 2.7
Length of working week for main job 2.7 3.0 4.6 -0.0 -2.1 -2.2
Exposure to tobacco smoke at home 0.3 0.4 0.5 0.7 -0.7 -0.3
Breastfed as a baby 0.1 0.1 0.2 0.3 0.4 -0.3
Tense / ‘highly strung’ 0.2 0.4 0.5 0.7 0.7 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.4 -0.6 -0.6 -0.2
Hair/balding pattern: Pattern 4 0.8 1.9 5.2 -0.8 -0.2 2.3
Birth weight of first child 2.2 4.0 7.6 -2.1 0.2 2.8
Peak expiratory flow (PEF) 0.5 1.3 3.4 0.3 1.8 0.5
Pulse wave reflection index 0.4 0.5 0.9 0.2 -1.0 0.7
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.8 0.8 -1.4 -0.2
Loud music exposure frequency 0.7 0.7 1.1 0.0 1.1 1.0
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 3.4 -0.7 1.8 0.8
Mouth/teeth dental problems: Bleeding gums 1.7 2.3 5.3 0.7 2.3 -1.0
Blood clot in the leg (DVT) 2.4 3.1 5.1 -1.6 1.2 2.3
Medication: Paracetamol 2.2 3.6 6.0 -2.1 -2.4 0.5
Headache pain in last month 1.8 3.0 4.6 -2.0 -2.1 0.7
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 -0.0 -0.2 -0.5
Glaucoma (self-reported) 1.0 1.2 2.4 0.2 1.5 -1.0
Gout (self-reported) 2.3 3.1 4.6 1.0 2.0 -2.2
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.6 -0.5 -0.1 -1.6
Medication: Amlodipine 1.0 1.4 2.0 1.4 -0.6 -1.4
Medication: Ventolin 100micrograms inhaler 0.4 0.5 0.9 1.0 -0.3 -0.6
Birth weight 0.1 0.3 0.8 0.0 0.9 0.2
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 0.8 -0.1 0.4
High blood pressure (siblings) 0.7 0.9 2.0 1.4 0.5 -0.8
Forced vital capacity (FVC), Best measure 0.6 2.1 4.6 -1.1 2.1 0.7
Body fat percentage 0.4 1.7 3.2 -1.4 -1.8 -0.2
Leg fat percentage (right) 0.6 2.0 4.9 -0.7 -2.2 -0.8
Arm fat-free mass (right) 0.6 3.1 6.4 -2.5 -1.2 1.2
Exposure to tobacco smoke outside home 2.8 3.7 7.7 -0.2 -2.8 1.8
Comparative body size at age 10 0.3 0.9 1.5 -0.0 1.2 -1.0
Number of full brothers 0.6 0.8 1.7 -0.9 -0.0 1.3
Worry too long after embarrassment 1.5 2.5 5.3 0.8 2.3 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 -0.6 -0.4 0.1
Wheeze or whistling in the chest in last year 0.5 0.9 1.6 1.3 1.1 -0.2
Number of children fathered 0.7 0.7 1.9 1.4 0.5 0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.1 1.0 -0.1 -0.4
Age at first live birth 0.6 1.0 1.5 -0.5 1.1 1.2
Pulse wave peak to peak time 0.4 0.5 0.7 0.6 0.6 -0.9
Health satisfaction 1.2 1.5 4.4 -2.1 -0.4 0.1
Shortness of breath walking on level ground 0.3 0.3 0.9 0.2 -0.9 -0.0
Qualifications: College or University degree 0.4 1.3 2.0 0.8 1.4 1.2
Eye problems/disorders: None of the above 1.3 1.5 2.4 0.3 -1.4 1.5
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.2 1.4 -0.4 -1.5
Emphysema/chronic bronchitis 0.3 0.3 0.5 0.6 -0.3 -0.7
Medication for pain relief, constipation, heartburn 0.8 1.3 2.8 0.6 1.7 0.9
Neck or shoulder pain in last month 1.3 1.8 4.8 -0.3 -2.2 -0.7
Medication: Blood pressure 0.2 0.3 0.6 0.4 0.8 -0.2
Angina (self-reported) 0.2 0.3 0.4 -0.4 0.7 -0.5
Migraine (self-reported) 1.8 2.3 5.9 -0.1 -1.0 2.4
Medication: Ibuprofen 0.3 0.3 0.5 -0.2 0.7 -0.7
Medication: Allopurinol 0.8 1.1 2.0 -0.7 0.8 -1.4
Medication: Omeprazole 1.4 1.7 2.2 -1.0 -1.5 1.4
Medication: Seretide 50 evohaler 0.1 0.1 0.3 -0.1 -0.3 0.5
Mean time to correctly identify matches 0.1 0.3 0.6 -0.4 -0.8 0.2
Heart disease (mother) 0.3 0.3 0.4 0.6 0.4 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.1 0.1 0.2 0.1 0.3
Whole body fat mass 0.6 2.4 3.8 -1.9 -1.8 0.5
Leg fat mass (right) 0.7 2.6 5.1 -1.6 -2.2 -0.1
Arm predicted mass (right) 0.8 3.8 8.0 -2.8 -1.4 1.3
Pulse rate, automated reading 0.8 2.5 5.5 -2.3 0.6 1.3
Alcohol intake frequency. 0.5 1.3 2.0 1.2 0.4 -1.4
Comparative height size at age 10 1.1 5.9 11.7 -3.4 0.3 2.4
Number of full sisters 0.6 0.7 1.4 -1.2 0.9 0.1
Suffer from ‘nerves’ 0.4 0.6 1.6 0.1 1.3 0.3
Overall health rating 0.2 0.5 1.0 -0.4 -0.6 1.0
Chest pain or discomfort 0.0 0.1 0.2 0.2 0.1 -0.4
Had major operations 0.2 0.2 0.7 -0.8 0.1 -0.1
Age at last live birth 1.3 1.9 3.5 -1.9 1.0 1.1
Family relationship satisfaction 0.3 0.4 0.6 -0.4 0.8 -0.5
Leg pain on walking 0.7 0.9 2.5 -0.0 -1.6 0.5
Qualifications: NVQ or HND or HNC or equivalent 3.2 3.8 6.9 2.6 0.2 -2.1
Commuting to job workplace: Car/motor vehicle 1.5 1.8 5.0 0.0 0.6 2.2
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 1.4 1.2 -1.0 -1.1
Medication: Aspirin 0.2 0.3 0.7 0.8 -0.3 -0.1
Supplements: Vitamin C 0.6 0.8 1.3 0.9 0.4 1.2
Knee pain experienced in last month 0.4 0.7 2.0 -1.4 0.0 0.3
Hypertension (Self-reported) 1.2 3.3 5.0 2.2 0.7 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 2.1 0.3 0.5 1.4
Illnesses of father: Heart disease 0.4 0.6 1.4 -1.2 -0.1 0.6
Illnesses of siblings: Diabetes 0.8 1.0 1.9 -1.4 -1.0 -0.2
Smoking status: Previous 3.8 5.6 16.7 -0.2 -4.1 0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 3.0 -1.7 -0.4 1.3
Whole body fat-free mass 1.0 5.4 9.3 -3.0 -1.2 2.4
Leg fat-free mass (right) 0.7 3.7 6.6 -2.6 -0.1 2.1
Arm fat percentage (left) 0.3 1.2 2.5 -1.0 -1.6 0.0
Average weekly red wine intake 2.1 3.2 4.9 2.2 -1.7 -1.3
Handedness (chirality/laterality): Left-handed 1.6 1.9 3.2 1.5 1.8 -0.7
Mood swings 0.0 0.0 0.1 -0.2 0.1 -0.0
Loneliness, isolation 0.3 0.4 0.5 -0.5 -0.7 0.7
Long-standing illness, disability or infirmity 0.3 0.4 1.1 -1.1 -0.3 -0.2
Ever had bowel cancer screening 0.4 0.4 1.1 -0.4 1.1 -0.1
Diabetes diagnosed by doctor 0.5 0.8 2.4 -0.4 -1.5 0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.1 -0.1 0.1 0.2
Friendships satisfaction 0.4 0.5 0.9 0.7 0.9 0.4
Qualifications: nursing, teaching 0.4 0.6 1.3 1.1 -0.2 0.8
Commuting to job workplace: Walk 2.1 2.2 6.2 0.6 -0.3 -2.5
Eye problems/disorders: Cataract 0.6 0.7 1.4 -0.1 1.2 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.8 1.2 2.0 0.9 -0.9 1.4
Medication for cholesterol 1.5 2.3 3.0 -1.7 1.2 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 3.0 -1.7 -0.3 0.1
Back pain experienced in last month 1.0 1.5 2.9 -1.7 -1.1 0.7
Mineral and other dietary supplements 0.2 0.2 0.4 -0.0 0.7 -0.5
Breast cancer (self-reported) 0.3 0.4 0.8 0.4 -0.9 -0.3
Asthma (self-reported) 0.4 0.8 1.3 1.1 -0.2 -1.1
Osteoporosis (self-reported) 0.8 1.0 2.6 0.5 -1.6 -0.3
Osteoarthritis (self-reported) 1.3 1.7 2.8 -1.5 -1.7 -0.0
Medication: Aspirin 0.5 0.7 1.7 1.3 -0.2 -0.5
Medication: Gliclazide 1.2 1.4 3.8 -0.5 -1.9 0.4
Illnesses of father: None of the above (group 1) 1.2 1.5 2.4 -1.6 -0.7 1.3
Smoking status: Current 0.1 0.2 0.5 -0.7 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.3 1.0 1.5 -0.3
Whole body water mass 0.9 5.2 9.0 -3.0 -1.2 2.2
Leg predicted mass (right) 0.7 3.6 6.3 -2.5 -0.2 2.1
Arm fat mass (left) 0.6 2.6 4.2 -2.1 -1.9 0.5
Number of self-reported non-cancer illnesses 0.4 0.7 0.9 0.8 -0.7 -0.9
Average weekly champagne plus white wine intake 0.6 0.9 1.8 -1.3 -0.6 0.7
Miserableness 0.7 1.2 1.5 1.2 1.2 -0.8
Guilty feelings 0.8 1.1 2.6 0.7 0.6 -1.6
Wears glasses or contact lenses 0.9 1.0 2.4 0.7 -0.1 1.6
Ever taken oral contraceptive pill 0.3 0.3 0.9 0.1 0.2 -0.9
Hearing aid user 0.3 0.3 0.6 -0.6 0.2 -0.8
Mother’s age at death 2.3 2.9 5.2 -1.8 0.2 2.3
Financial situation satisfaction 0.0 0.0 0.1 -0.1 0.2 -0.2
Tinnitus: Yes, now most or all of the time 0.6 0.7 1.8 -0.5 -1.3 -0.4
Commuting to job workplace: Public transport 1.1 1.3 2.4 1.2 0.1 -1.5
Eye problems/disorders: Glaucoma 0.9 1.0 2.8 0.2 1.7 -0.6
Medication: Blood pressure 2.2 4.2 6.9 2.6 -0.4 -2.3
Pain type(s) experienced in last month: Hip pain 1.6 2.0 4.7 0.7 -0.8 -2.2
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.0 0.4 -1.0 -0.7
High cholesterol (Self-reported) 1.3 2.3 3.9 2.0 -0.8 -1.5
Medication: Bendroflumethiazide 1.5 2.3 4.4 0.8 1.3 -2.1
Medication: Paracetamol 1.4 2.1 3.7 -1.6 -1.9 -0.4
Medication: Lisinopril 0.3 0.4 0.8 0.3 0.9 -0.6
Medication: Atorvastatin 0.4 0.5 0.9 0.7 -0.3 -1.0
Illnesses of father: High blood pressure 0.5 0.6 1.5 0.3 0.5 -1.2
Alcohol drinker status: Never 3.4 4.0 12.0 3.5 0.3 0.1
Ever smoked 1.2 2.0 5.4 -0.5 -2.3 -0.7
Basal metabolic rate 0.9 4.9 9.1 -3.0 -1.2 2.0
Leg fat percentage (left) 0.5 1.7 3.9 -0.7 -2.0 -0.8
Arm fat-free mass (left) 1.0 4.9 8.4 -2.9 -1.9 1.6
Number of operations (self-reported) 0.2 0.3 0.4 0.4 0.7 -0.6
Average weekly beer plus cider intake 0.4 0.5 1.5 0.2 -0.0 -1.2
Irritability 0.3 0.4 1.1 0.2 -1.1 0.4
Risk taking 1.4 2.1 5.9 -2.4 0.0 0.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.8 0.9 -0.2 -0.2
Fractured/broken bones in last 5 years 0.5 0.6 1.7 0.3 0.1 1.3
Age started oral contraceptive pill 1.2 1.5 3.0 -0.5 -1.7 -1.1
Diastolic blood pressure, automated reading 2.4 7.3 10.6 2.2 2.5 -3.3
Ever depressed for a whole week 0.0 0.1 0.1 -0.2 -0.2 -0.2
Unable to work because of sickness or disability 0.2 0.3 0.5 0.7 -0.2 0.6
Commuting to job workplace: Cycle 1.6 2.0 3.1 -1.1 -1.8 -1.3
Myopia 0.7 1.0 1.5 -1.1 1.2 0.3
Vascular/heart problems diagnosed by doctor 0.9 2.4 3.7 -1.9 -0.3 1.9
Cholesterol lowering medication 3.5 5.2 6.5 2.2 -2.5 -2.0
Medication: Omeprazole (e.g. Zanprol) 0.6 0.8 1.5 -0.5 -0.8 1.2
Pain experienced in last month 0.7 1.2 2.4 1.1 1.6 -0.1
Supplements: Calcium 0.5 0.5 1.5 0.3 -1.2 0.2
Basal cell carcinoma (self-reported) 0.5 0.6 1.1 0.1 -1.1 0.8
Heart attack/myocardial infarction (self-reported) 0.6 0.7 2.1 -0.2 -1.5 0.1
Deep venous thrombosis (DVT) (self-reported) 2.2 2.9 5.7 -1.4 1.0 2.4
Heart disease (siblings) 0.3 0.3 0.5 -0.3 -0.7 -0.6
Alcohol drinker status: Previous 0.4 0.5 0.8 -0.9 -0.5 -0.6
Pack years of smoking 0.2 0.3 0.8 -0.1 0.9 0.4
Impedance of whole body 0.2 1.1 1.5 1.0 1.2 -0.9
Leg fat mass (left) 0.6 2.4 4.5 -1.7 -2.1 -0.0
Arm predicted mass (left) 1.0 5.0 8.5 -2.9 -1.8 1.8