TWAS hub - RBL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.100	0.0410	0.00063	-0.001	0.026	0.009	0.032	0.004	0.41000	0.00034	0.023	7.8e-05	0.1100
2	GTEx	Artery Aorta	0.092	0.0450	0.00590	0.010	NA	0.001	NA	0.010	0.08800	NA	0.260	NA	0.0910
3	GTEx	Nerve Tibial	0.072	0.0306	0.00290	0.014	NA	0.030	NA	0.012	0.03200	NA	0.003	NA	0.0450
4	GTEx	Thyroid	0.104	0.0470	0.00052	0.045	NA	0.015	NA	0.030	0.00021	NA	0.023	NA	0.0022
5	TCGA	Thyroid Carcinoma	0.039	0.0270	0.00850	0.012	0.015	0.009	NA	0.005	0.02200	0.01300	0.037	NA	0.0860

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Knee pain experienced in last month	7.8	12.1	17.9	-2.6	-4.0	2.0	4.0	4.2
Maternal smoking around birth	4.6	6.7	9.7	-2.0	-3.0	1.5	3.1	2.9
Alcohol intake frequency.	4.3	10.0	18.0	-2.6	-2.9	2.2	3.5	4.2
Financial situation satisfaction	4.3	5.3	11.1	-1.8	-2.6	0.8	2.2	3.3
Tanning	4.0	49.3	82.8	-6.7	9.1	-6.1	-7.9	-4.3
Hair/balding pattern: Pattern 2	3.5	4.5	7.2	-1.1	2.5	-1.3	-2.4	-2.7
Fractured/broken bones in last 5 years	3.2	4.1	6.7	1.2	2.5	-1.7	-2.6	-1.8
Commuting to job workplace: Walk	3.0	3.3	7.0	0.3	1.9	-0.9	-2.6	-2.2
Supplements: Calcium	3.0	3.3	3.8	-1.6	-1.9	2.0	1.8	1.9
Ovarian Cancer	2.9	3.8	7.3	1.6	2.7	-1.0	-2.3	-1.6
Alcohol intake versus 10 years previously	2.8	4.2	8.5	-0.7	-2.1	1.9	2.0	2.9
Pain experienced in last month	2.8	4.7	8.9	1.3	2.2	-1.3	-2.6	-3.0
Average weekly champagne plus white wine intake	2.6	3.6	6.5	0.4	1.8	-1.5	-2.4	-2.6
Diabetes (mother)	2.4	3.1	5.5	-0.9	-1.6	2.3	1.8	1.8
Hearing difficulty/problems with background noise	2.2	3.5	5.7	2.4	2.1	-2.1	-1.2	-1.1
Back pain experienced in last month	2.2	3.3	6.8	0.2	-1.9	0.0	2.6	2.4
Diabetes (father)	2.1	2.5	6.4	0.4	1.5	-2.5	-1.6	-1.0
Comparative height size at age 10	2.1	11.7	32.9	5.7	-2.1	-2.6	2.2	3.0
Number of full sisters	2.1	2.5	3.6	-1.6	-1.8	1.0	1.9	1.6
Vitamin and mineral supplements	2.0	2.7	7.1	2.7	0.8	-1.4	-0.8	-1.7
Pulse wave peak to peak time	2.0	2.3	2.9	1.3	1.5	-1.4	-1.6	-1.7
Major Depression (MDD)	1.9	2.3	5.6	-0.1	-2.4	0.2	2.0	1.4
Qualifications: CSEs or equivalent	1.9	2.5	4.1	-0.5	-1.9	0.7	2.0	2.0
Angina (self-reported)	1.9	2.5	5.0	0.8	2.2	-1.1	-1.5	-1.8
Glaucoma (self-reported)	1.8	2.1	3.5	-0.4	1.7	1.4	-1.9	-1.4
Hearing difficulty/problems: Yes	1.7	2.6	10.2	0.1	0.7	-3.2	-1.1	-1.0
Basal cell carcinoma (self-reported)	1.7	2.0	3.2	1.6	-1.8	-1.0	1.5	0.8
Fasting Glucose	1.6	1.9	5.1	-1.8	-1.0	2.3	-0.0	-0.4
Hair Pigment	1.6	44.4	90.0	4.2	-9.5	7.0	7.4	3.2
Average weekly spirits intake	1.6	1.9	3.5	0.3	1.4	-1.3	-1.9	-1.6
Supplements: Zinc	1.6	1.8	5.8	-2.4	0.8	1.4	-0.5	0.5
Medication: Ramipril	1.6	2.0	5.9	-1.9	-0.1	2.4	0.1	0.7
Worrier / anxious feelings	1.6	3.0	6.5	-0.7	1.7	-0.9	-2.5	-2.1
Pulse wave Arterial Stiffness index	1.6	1.9	2.5	-1.0	-1.4	1.3	1.5	1.6
Suffer from ‘nerves’	1.6	2.5	4.3	-0.2	2.0	-1.2	-2.1	-1.6
Supplements: Vitamin C	1.6	1.9	4.8	-2.2	-0.1	1.5	0.2	1.6
Stomach or abdominal pain in last month	1.5	1.8	3.4	1.8	-1.3	0.6	1.4	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	4.9	0.0	-1.9	0.3	2.0	2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.9	1.4	1.3	-0.4	-1.5	-1.7
Health satisfaction	1.5	2.0	3.6	-0.9	-1.9	0.6	1.3	1.8
Medication: Atorvastatin	1.5	1.8	2.8	1.3	1.5	-1.1	-1.7	-1.0
Frequency of depressed mood in last 2 weeks	1.4	2.0	4.5	0.7	-1.6	0.2	1.5	2.1
Chronic bronchitis/emphysema (father)	1.4	1.7	4.1	2.0	-1.1	-0.7	1.4	0.8
Hair/balding pattern: Pattern 3	1.4	2.2	5.0	1.1	-1.1	2.2	1.2	1.4
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	9.5	-0.2	-3.1	0.2	2.7	2.6
Medication: Paracetamol	1.4	2.4	5.3	-1.3	-1.3	0.8	1.6	2.3
Leg pain on walking	1.4	1.8	2.9	-1.7	-1.1	0.8	1.1	1.7
Average weekly red wine intake	1.4	2.1	5.2	2.3	0.8	-0.7	-1.1	-1.7
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	2.3	0.9	-1.2	-1.2	1.5	1.1
Angina	1.3	1.8	3.4	0.7	1.8	-1.1	-1.2	-1.6
Forced vital capacity (FVC)	1.3	4.9	8.9	0.5	-2.9	0.3	3.0	2.6
Peak expiratory flow (PEF)	1.3	3.0	5.2	0.3	-2.2	0.2	2.3	2.1
Migraine (self-reported)	1.3	1.6	2.4	-0.2	1.5	-1.3	-1.5	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	4.5	1.3	0.3	-2.1	-0.8	-0.8
Pulse rate	1.2	1.9	2.8	-0.2	-1.7	1.4	1.5	1.6
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.1	1.8	-0.3	-1.6	-0.6	-1.2
Medication: Aspirin	1.2	1.6	3.2	0.3	1.8	-0.3	-1.6	-1.3
Medication: Gliclazide	1.2	1.3	2.5	-1.1	-1.0	-0.2	1.6	1.4
Lung FVC	1.1	5.6	8.6	-1.7	-2.5	1.2	2.9	2.9
Relative age of first facial hair	1.1	2.2	7.1	-2.7	-1.0	1.7	0.3	-0.6
Asthma	1.1	2.2	2.6	1.5	1.6	-1.6	-1.1	-1.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.8	1.7	-1.3	0.2	0.9	1.2
Qualifications: nursing, teaching	1.1	1.8	2.7	0.7	1.6	-1.5	-1.4	-1.2
Asthma (self-reported)	1.1	2.1	3.2	1.8	1.4	-1.5	-1.1	-1.3
Ever taken oral contraceptive pill	1.1	1.2	3.2	-0.3	0.9	-1.0	-1.1	-1.8
Commuting to job workplace: Public transport	1.1	1.3	4.9	-1.0	-0.3	2.2	0.4	0.5
Myopia	1.1	1.6	5.2	-2.3	-1.4	0.4	0.7	0.7
Respiratory disease	1.0	2.1	2.7	1.1	1.6	-1.6	-1.5	-1.4
Multivitamins +/- minerals	1.0	1.3	5.2	-2.3	-0.3	0.6	0.3	0.8
Father’s age at death	1.0	1.4	5.9	-2.4	0.0	0.5	-0.6	-0.5
Hair/balding pattern: Pattern 4	1.0	2.3	7.6	2.8	-0.7	-1.9	-0.1	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	5.3	-2.3	0.9	1.2	-0.7	-0.0
Wears glasses or contact lenses	1.0	1.1	3.7	-1.9	-0.4	1.0	-0.8	-0.1
Alcohol drinker status: Never	1.0	1.2	3.3	0.4	-0.6	-0.7	1.4	1.8
Worry (Nagel 2018)	0.9	1.9	3.6	-1.6	1.0	-0.5	-1.9	-1.3
Ulcerative Colitis (UC)	0.9	1.7	2.7	1.1	1.3	-1.0	-1.4	-1.7
Medication: Atenolol	0.9	1.1	1.4	1.2	-0.7	1.2	1.0	1.1
Sitting height	0.9	6.5	18.1	4.3	1.1	-3.4	-1.3	-0.7
Happiness	0.9	1.1	3.2	0.3	-1.2	0.1	1.0	1.8
Medication: Lansoprazole	0.9	1.0	2.2	-0.2	-1.0	0.1	1.3	1.5
Breastfed as a baby	0.9	1.1	2.9	0.8	-0.2	1.7	0.9	1.0
Comparative body size at age 10	0.9	2.4	11.6	0.7	0.1	-3.4	-0.1	-0.1
Eye problems/disorders: None of the above	0.9	1.0	3.2	0.4	0.2	-1.8	-0.5	-1.2
Neck or shoulder pain in last month	0.9	1.2	2.8	-0.5	-1.2	-1.7	0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	2.5	-0.7	-1.2	0.0	1.1	1.6
Rheumatoid Arthritis	0.8	1.1	4.9	0.2	-0.4	2.2	0.6	-0.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.0	0.5	-1.0	0.6	1.4	1.3
Hand grip strength (right)	0.8	2.1	4.1	0.6	-2.0	0.3	2.0	1.5
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.0	-0.6	0.6	0.1	-1.7	-1.7
Medication: Amlodipine	0.8	1.1	4.4	-2.1	-0.3	-0.5	0.6	0.6
Age at last live birth	0.8	1.2	1.8	-1.0	1.3	-0.7	-1.3	-0.9
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	-1.0	-0.9	-1.3	0.8	0.7
Miserableness	0.8	1.3	4.2	2.0	0.7	-0.9	-0.8	-0.7
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.9	0.8	0.1	1.7	-0.4	-1.0
Reaction Time	0.7	1.3	2.5	1.6	1.1	-1.6	-0.5	-0.4
Crohns Disease (2012)	0.7	1.1	3.5	0.8	-0.5	1.9	0.6	0.7
Lung FEV1/FVC ratio	0.7	3.5	5.7	-2.1	0.6	-2.0	-2.4	-1.8
Ever had hysterectomy (womb removed)	0.7	0.8	3.2	-1.8	-0.6	-0.6	0.1	0.2
Medication: Metformin	0.7	0.9	1.7	-1.1	-0.2	-0.7	1.1	1.3
Leg fat-free mass (left)	0.7	3.5	8.8	1.5	-1.3	-3.0	1.4	1.7
Relative age voice broke	0.7	1.0	2.3	-1.4	-0.4	1.5	-0.0	-0.7
Leg predicted mass (left)	0.7	3.5	8.5	1.6	-1.3	-2.9	1.4	1.7
Alcohol usually taken with meals	0.7	1.2	2.7	-1.3	-0.7	1.6	0.9	0.2
Financial difficulties in last 2 years	0.7	1.0	2.3	-0.0	-0.9	0.4	1.5	1.3
Pain all over the body in last month	0.7	0.7	1.3	0.4	1.0	0.4	-1.2	-0.9
Weight	0.7	3.4	10.5	1.5	-1.0	-3.2	1.1	1.3
Prospective memory result	0.7	0.8	2.0	-0.3	-1.0	0.2	1.0	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.7	-0.2	-2.2	0.2	1.8	1.9
Exposure to tobacco smoke at home	0.7	0.8	1.5	-0.0	1.2	-1.2	-0.8	-0.8
Arm fat-free mass (right)	0.7	3.6	14.1	1.4	-0.5	-3.8	0.4	1.3
Worry too long after embarrassment	0.7	1.2	2.7	-0.3	-1.6	1.3	1.0	0.8
Qualifications: College or University degree	0.7	2.0	3.6	0.9	1.9	0.3	-1.6	-1.8
Emphysema/chronic bronchitis	0.7	0.7	1.2	0.2	0.8	-1.1	-1.1	-0.8
Arm predicted mass (right)	0.7	3.7	12.3	1.6	-0.9	-3.5	0.7	1.5
Leg fat-free mass (right)	0.7	3.7	8.1	1.4	-1.5	-2.9	1.5	2.0
Ever had bowel cancer screening	0.7	0.9	2.1	-1.4	-0.7	1.2	0.6	0.0
Mineral and other dietary supplements	0.7	1.0	1.7	1.1	0.7	-1.3	-0.3	-1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	3.3	-0.8	-0.5	1.8	0.4	0.3
Leg predicted mass (right)	0.7	3.8	8.0	1.4	-1.6	-2.8	1.5	2.0
Medication: Bendroflumethiazide	0.7	1.0	1.7	-1.1	-1.1	-0.3	0.8	1.3
Basal metabolic rate	0.7	3.8	12.6	1.5	-0.9	-3.5	1.0	1.5
Arm fat-free mass (left)	0.7	3.5	13.7	1.1	-0.7	-3.7	0.6	1.4
Irritability	0.7	1.1	4.5	-0.2	-0.9	2.1	0.5	0.4
Arm predicted mass (left)	0.7	3.6	13.3	1.2	-0.8	-3.6	0.7	1.4
Alzheimer’s Disease (in mother)	0.6	0.7	1.6	-0.1	-1.1	0.4	1.3	0.9
Verbal and Numeric Reasoning (VNR)	0.6	1.5	2.8	-0.5	1.2	0.6	-1.7	-1.6
Ulcerative Colitis	0.6	0.9	2.5	1.6	1.0	-0.4	-0.5	-0.7
Height	0.6	12.0	40.7	6.4	-0.3	-3.6	0.3	2.4
Medication for hormone replacement therapy	0.6	0.6	2.0	-0.8	-0.7	-1.4	0.0	0.0
Impedance of leg (right)	0.6	2.8	3.8	1.4	1.9	1.3	-1.8	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	1.0	-0.6	0.5	0.9	1.3
Age when periods started (menarche)	0.6	1.5	4.5	-1.3	-0.9	2.1	0.9	0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.2	-1.8	0.0	-0.2	-0.7	-0.3
Trunk fat-free mass	0.6	3.3	12.8	1.2	-0.6	-3.6	0.5	1.2
Trunk predicted mass	0.6	3.3	13.5	1.3	-0.4	-3.7	0.4	1.1
Forced vital capacity (FVC), Best measure	0.6	2.0	3.5	0.5	-1.9	0.1	1.8	1.8
Exposure to tobacco smoke outside home	0.6	0.8	1.8	-0.5	-0.1	1.1	1.0	1.3
Wheeze or whistling in the chest in last year	0.6	1.1	2.0	-1.4	-0.1	1.1	0.7	1.3
Overall health rating	0.6	1.4	4.2	-0.1	-0.9	-0.7	1.1	2.1
Family relationship satisfaction	0.6	0.7	1.8	-0.3	-1.0	0.3	0.8	1.3
Whole body fat-free mass	0.6	3.5	11.6	1.4	-0.9	-3.4	0.9	1.6
Whole body water mass	0.6	3.7	11.7	1.4	-1.0	-3.4	1.0	1.7
Number of operations (self-reported)	0.6	0.9	1.5	-1.2	-0.8	-0.1	1.1	1.1
Ever depressed for a whole week	0.6	0.7	2.4	1.5	0.3	-0.9	-0.4	-0.2
Cholesterol lowering medication	0.6	1.0	2.2	-0.7	1.5	0.3	-1.2	-0.7
Impedance of whole body	0.6	2.9	4.7	2.2	1.2	2.1	-1.2	-1.5
Intelligence (Savage-Jansen 2018)	0.5	1.6	3.3	-0.3	1.5	0.6	-1.8	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	2.6	-1.6	-0.1	0.8	-0.4	0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.8	0.7	0.2	-1.3	-0.0	-0.5
Age at First Birth	0.5	0.7	2.3	-1.5	-0.0	0.9	-0.5	-0.4
Blood Red Count	0.5	4.5	8.4	-0.7	-2.6	0.4	2.6	2.9
Hand grip strength (left)	0.5	1.3	2.5	-0.5	-1.6	-0.4	1.5	1.2
Systolic blood pressure, automated reading	0.5	1.3	3.1	-1.8	-0.0	1.6	0.3	0.9
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.3	-0.6	1.2	-0.4	-0.9	-0.7
Body mass index (BMI)	0.5	2.2	6.8	-0.3	-1.1	-2.6	1.3	1.0
Trunk fat mass	0.5	2.1	7.1	1.6	-0.5	-2.7	0.5	0.4
Waist circumference	0.5	1.9	8.7	-0.2	-0.3	-2.9	0.6	0.6
Qualifications: None of the above	0.5	1.0	2.3	-0.2	1.5	-1.5	-0.8	-0.3
Impedance of arm (right)	0.5	2.1	5.6	1.8	0.6	2.4	-0.5	-1.1
Falls in the last year	0.5	0.6	1.6	1.3	0.9	-0.8	-0.1	0.3
Illnesses of mother	0.5	0.6	2.3	1.5	0.1	-0.8	-0.2	-0.2
Impedance of arm (left)	0.5	2.5	6.5	2.3	0.3	2.5	-0.2	-0.8
Headache pain in last month	0.5	0.9	1.8	-0.6	-0.8	-0.5	1.2	1.3
Number of full brothers	0.5	0.6	0.7	0.8	0.8	-0.8	-0.7	-0.8
Shortness of breath walking on level ground	0.5	0.6	2.2	-1.5	-0.2	-0.4	-0.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.7	0.8	0.1	0.6	0.6	1.3
Medication: Aspirin	0.5	0.6	1.6	0.2	1.3	-0.1	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.4	1.9	-0.8	-0.6	0.5	0.9
Breast cancer (self-reported)	0.5	0.6	2.0	-0.5	-0.2	1.4	0.4	0.7
Arm fat mass (left)	0.5	2.0	6.7	0.8	-1.0	-2.6	1.1	0.9
Medication: Paracetamol	0.5	0.7	2.2	-0.2	-0.5	0.7	0.8	1.5
Average weekly beer plus cider intake	0.5	0.7	0.9	0.7	-0.8	-0.9	0.9	0.9
Bipolar Disorder (2018)	0.4	0.7	2.9	0.6	0.4	-1.7	-0.1	-0.3
Breast Cancer	0.4	0.9	2.9	-0.8	0.2	0.6	0.8	1.7
Body Mass Index (BMI) (2010)	0.4	0.6	2.0	-1.4	-0.6	-0.3	0.6	0.2
BMI	0.4	2.3	10.8	0.1	-0.4	-3.3	0.4	0.6
Waist Hip Ratio (WHR)	0.4	2.0	2.9	-0.8	1.2	-1.5	-1.7	-1.7
Type 2 Diabetes (T2D) (2018)	0.4	0.7	2.2	-0.6	0.1	-1.5	0.7	0.5
Medication: Co-codamol	0.4	0.5	1.0	-0.3	-0.3	0.6	1.0	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.1	-1.0	-0.5	0.1	0.7	0.7
Impedance of leg (left)	0.4	2.2	2.6	1.2	1.6	1.5	-1.6	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.4	1.2	-0.7	0.6	0.5	0.7
Had menopause	0.4	0.5	1.0	-0.3	0.6	-0.1	-1.0	-0.9
Had other major operations	0.4	0.5	1.9	0.7	0.5	-1.4	0.3	0.2
Mouth/teeth dental problems	0.4	0.6	1.6	0.5	-1.3	0.1	1.0	0.5
Allergy	0.4	0.9	2.1	-0.4	-1.2	0.3	1.4	0.9
Hip circumference	0.4	1.9	7.6	1.1	-0.1	-2.8	0.6	0.5
Time employed in main current job	0.4	0.5	1.2	-0.1	0.8	-0.2	-1.1	-0.8
Noisy workplace	0.4	0.5	0.8	-0.8	-0.7	-0.2	0.9	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.5	-1.2	-0.2	-0.2	0.2	0.9
Arm fat mass (right)	0.4	1.8	6.7	0.5	-0.8	-2.6	1.0	0.7
Standing height	0.4	4.2	17.2	4.2	0.0	-1.8	-0.0	0.8
Length of working week for main job	0.4	0.4	0.8	0.4	-0.9	0.2	0.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.2	1.0	-0.5	-1.1	0.4	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.6	0.9	0.7	0.8	-0.9	-0.7	-0.6
Leg fat percentage (right)	0.4	1.4	6.4	-0.0	0.3	-2.5	-0.2	-0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.6	-0.2	1.3	0.2	-0.9	-0.3
Whole body fat mass	0.4	1.8	7.6	0.8	-0.4	-2.8	0.6	0.5
Leg fat mass (right)	0.4	1.7	8.2	0.3	-0.2	-2.9	0.4	0.3
Had major operations	0.4	0.5	0.6	-0.5	-0.6	0.8	0.8	0.8
Long-standing illness, disability or infirmity	0.4	0.7	2.1	-0.2	-0.7	-0.0	0.8	1.5
Number of self-reported non-cancer illnesses	0.4	0.6	1.0	0.8	1.0	-0.9	-0.8	-0.1
Guilty feelings	0.4	0.5	2.5	-1.6	-0.4	0.1	-0.2	-0.0
Eye problems/disorders: Glaucoma	0.4	0.4	1.2	0.4	0.8	1.1	-0.5	0.1
Leg fat percentage (left)	0.4	1.4	6.9	-0.1	-0.0	-2.6	-0.1	-0.4
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.9	-0.6	0.8	0.8	0.2
Heart disease (siblings)	0.4	0.4	1.0	-0.1	0.5	-1.0	-0.6	-0.7
Leg fat mass (left)	0.4	1.7	8.0	0.4	-0.4	-2.8	0.5	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.1	0.7	0.0	-1.0	-0.1	0.4
Systolic Blood Pressure	0.3	1.3	2.7	-1.0	-0.3	1.6	0.7	1.6
Cardiovascular Disease	0.3	1.1	2.8	-0.1	1.7	-0.8	-1.3	-0.6
Chronotype (morning person)	0.3	0.8	1.7	0.9	1.3	-0.2	-0.7	-1.0
Number of treatments/medications taken	0.3	0.5	1.4	-0.8	-0.1	0.0	0.6	1.2
Pack years adult smoking proportion	0.3	0.5	1.1	-0.4	0.3	-1.0	0.6	0.8
Trunk fat percentage	0.3	1.1	3.2	1.3	-0.5	-1.8	0.5	0.2
Average weekly fortified wine intake	0.3	0.4	0.9	-1.0	0.2	0.8	-0.3	0.5
High blood pressure	0.3	0.9	1.7	-0.5	1.3	-1.2	-1.1	-0.1
Supplements: Glucosamine	0.3	0.3	0.9	-0.1	-0.4	-1.0	0.3	0.7
Medication: Levothyroxine sodium	0.3	0.5	1.1	1.1	0.7	-0.8	0.3	0.2
High blood pressure (mother)	0.3	0.4	0.9	-0.5	0.9	-0.8	-0.4	-0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.1	1.0	-0.5	-0.8	0.1	-0.0
Diabetes (self-reported)	0.3	0.4	1.3	-0.2	0.8	-1.1	-0.3	-0.0
Illnesses of siblings	0.3	0.4	0.6	0.7	0.4	0.7	-0.7	-0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.0	-0.9	0.3	0.4	-1.0	-1.0
Depression (self-reported)	0.3	0.4	1.5	-0.2	0.4	-1.2	-0.4	0.2
Loud music exposure frequency	0.3	0.4	0.9	-0.3	-1.0	0.2	0.6	0.6
Blood clot in the leg (DVT)	0.3	0.4	1.2	-1.1	0.7	0.3	-0.6	-0.2
Gout (self-reported)	0.3	0.5	0.9	-0.4	0.5	-0.9	-0.8	-0.5
Birth weight	0.3	0.7	2.3	-0.1	0.1	-1.5	-0.8	-0.5
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.4	0.7	-0.8	-0.4	-0.4
Body fat percentage	0.3	1.2	5.0	0.9	-0.1	-2.2	0.2	-0.2
Age at first live birth	0.3	0.5	1.8	-1.3	0.2	0.3	-0.6	-0.2
Medication: Allopurinol	0.3	0.5	1.9	-1.4	0.0	-0.4	-0.1	0.5
Hypertension (Self-reported)	0.3	0.9	1.6	-0.3	1.3	-1.2	-1.2	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.2	0.1	-0.3	1.1	0.5	0.5
Illnesses of siblings: Diabetes	0.3	0.4	0.8	-0.8	-0.1	0.1	0.9	0.6
Arm fat percentage (left)	0.3	1.1	4.1	0.6	-0.6	-2.0	0.8	0.1
Loneliness, isolation	0.3	0.4	0.7	-0.0	0.8	-0.8	-0.7	0.1
Diabetes diagnosed by doctor	0.3	0.4	0.8	-0.6	0.2	-0.9	0.5	0.7
Eye problems/disorders: Cataract	0.3	0.4	1.3	-0.4	0.4	1.1	-0.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.1	-1.4	-0.8	0.7	0.3	-0.0
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.4	-1.2	0.3	0.2	-0.3	0.2
Medication: Blood pressure	0.3	0.5	1.1	-0.8	0.8	-0.5	-1.0	-0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.2	-1.1	-0.1	0.6	-0.1	0.3
High cholesterol (Self-reported)	0.3	0.6	1.4	-1.2	0.4	1.0	-0.1	0.5
Age started oral contraceptive pill	0.3	0.4	1.6	-1.2	0.2	0.6	0.0	-0.1
Diastolic blood pressure, automated reading	0.3	0.8	1.8	-1.0	-0.3	0.4	1.0	1.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	0.3	-1.4	0.9	1.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.5	-1.2	0.6	0.3	-0.4	0.1
Alcohol drinker status: Previous	0.3	0.3	0.6	-0.6	0.8	0.4	-0.5	-0.1
Pack years of smoking	0.3	0.4	0.8	-0.9	0.3	-0.6	0.5	0.8
Depressed Affect (Nagel 2018)	0.2	0.3	0.8	0.9	0.4	-0.8	-0.4	-0.1
Depression (Nagel 2018)	0.2	0.3	0.6	0.8	-0.4	0.5	0.3	0.8
Schizophrenia (2018)	0.2	0.4	1.8	-1.3	-0.6	-0.1	0.2	0.1
Alzheimer’s Disease (including proxy)	0.2	0.2	0.5	0.7	-0.0	-0.7	0.4	-0.3
Crohns Disease (2017)	0.2	0.4	1.5	-0.1	-0.5	1.2	-0.2	0.3
Irritable Bowel Disease (IBD)	0.2	0.5	0.9	0.6	0.6	0.4	-1.0	-0.8
Prostate Cancer	0.2	0.3	1.2	-0.4	-0.0	-1.1	-0.5	-0.4
Mean Putamen Volume	0.2	0.3	0.7	-0.9	-0.7	-0.0	0.2	-0.2
HbA1C	0.2	0.2	0.5	0.7	-0.3	-0.2	0.4	0.2
Lupus	0.2	0.3	0.6	0.8	0.1	0.3	-0.2	-0.8
Primary Biliary Cirrhosis	0.2	0.3	1.4	1.2	-0.4	-0.1	0.3	0.2
Schizophrenia (2014)	0.2	0.4	1.3	-0.8	0.1	-1.2	-0.2	-0.1
Blood Platelet Count	0.2	2.0	5.5	-2.3	-0.8	1.1	1.1	1.2
Heel T-Score	0.2	1.7	4.6	2.1	1.0	-0.7	-0.7	-1.4
Hypothyroidism (self reported)	0.2	0.6	1.3	1.1	1.0	-0.7	-0.1	-0.2
Townsend deprivation index at recruitment	0.2	0.3	0.7	0.3	-0.3	0.4	0.5	0.8
Fed-up feelings	0.2	0.3	1.3	0.5	0.2	-1.2	-0.2	0.3
Taking other prescription medications	0.2	0.3	0.6	-0.8	-0.2	0.0	0.4	0.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.2	-0.4	0.1	0.8	0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.7	0.7	0.3	-0.1	0.3	0.8
Medication: Simvastatin	0.2	0.3	0.9	-1.0	0.4	-0.2	-0.4	-0.2
Fluid intelligence score	0.2	0.4	0.9	-0.1	0.6	1.0	-0.6	-0.7
Arm fat percentage (right)	0.2	0.8	3.4	0.1	-0.5	-1.9	0.6	0.1
Mouth/teeth dental problems: Dentures	0.2	0.4	1.6	-1.3	0.2	0.3	-0.3	-0.1
Birth weight of first child	0.2	0.3	1.0	1.0	-0.0	0.6	0.5	0.3
Pulse wave reflection index	0.2	0.2	0.7	-0.2	-0.3	0.3	0.5	0.8
Number of children fathered	0.2	0.2	0.8	0.4	-0.2	-0.9	0.2	0.3
Medication: Ibuprofen	0.2	0.3	0.9	0.9	0.5	-0.3	-0.2	0.1
Chest pain or discomfort	0.2	0.3	0.5	0.2	0.5	-0.7	0.5	0.7
Illnesses of father: Heart disease	0.2	0.2	1.1	-1.1	-0.1	0.2	0.2	0.0
Smoking status: Previous	0.2	0.3	0.8	-0.3	-0.5	0.1	0.7	0.9
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.5	-0.3	0.5	-0.7	-0.4	-0.5
Mood swings	0.2	0.4	1.6	1.3	0.5	-0.1	-0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.3	-0.7	0.1	0.1	0.7
Medication for cholesterol	0.2	0.3	0.7	0.8	0.1	0.8	0.3	-0.3
Osteoporosis (self-reported)	0.2	0.3	0.6	-0.6	-0.7	0.3	0.6	0.1
Hearing aid user	0.2	0.3	0.7	-0.8	-0.3	0.7	0.1	0.3
Risk taking	0.2	0.3	0.8	0.9	0.5	-0.7	0.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	0.3	0.8	-0.5	-0.2	-0.4
Bipolar Disorder or Schizophrenia	0.1	0.4	1.2	-0.7	-0.2	-1.1	0.1	-0.1
Neuroticism (Nagel 2018)	0.1	0.2	0.4	-0.2	0.4	-0.1	-0.6	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.6	0.0	0.0	0.0	0.0	-0.8
Coronary Artery Disease (CAD)	0.1	0.2	0.4	0.2	-0.4	-0.4	0.7	0.3
HDL Cholesterol	0.1	0.1	0.4	-0.1	-0.2	0.6	0.3	0.4
Neuroticism (2016)	0.1	0.2	0.9	0.9	0.2	0.0	-0.4	0.1
Triglycerides	0.1	0.2	0.7	0.2	-0.4	-0.4	0.8	0.3
Blood Eosinophil Count	0.1	0.6	1.2	0.3	-0.4	-0.7	1.0	1.1
Blood White Count	0.1	0.7	1.3	0.7	-0.8	0.2	1.1	1.2
Smoking Status	0.1	0.3	1.0	-0.0	-0.3	-1.0	0.0	0.4
Allergy or Eczema	0.1	0.2	0.7	0.1	-0.1	0.8	-0.5	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.4	0.4	-0.6	-0.5	0.2	0.4
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.4	0.2	-0.2	0.6	-0.4	0.1
Number of incorrect matches in round	0.1	0.1	0.4	0.6	-0.3	0.3	0.2	0.2
Past tobacco smoking	0.1	0.1	0.4	0.7	-0.2	-0.1	-0.2	-0.2
Nervous feelings	0.1	0.2	0.4	-0.1	0.3	0.6	-0.6	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.2	0.4	0.1	-0.4	-0.5	-0.4
Heart attack	0.1	0.1	0.3	0.5	-0.3	0.1	0.4	0.1
Neuroticism score	0.1	0.1	0.5	-0.1	-0.0	-0.2	-0.7	-0.4
Number of live births	0.1	0.2	0.6	-0.4	-0.2	-0.8	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.5	-0.0	0.3	-0.7	-0.3	-0.1
Tense / ‘highly strung’	0.1	0.2	0.7	-0.8	-0.2	-0.3	0.0	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.1	0.1	0.3	0.2	0.5
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.3	-0.2	-0.5	0.2	0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.4	0.5	0.7	-0.4	0.5	0.3
High blood pressure (siblings)	0.1	0.1	0.2	-0.2	0.1	-0.4	0.3	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.2	0.6	0.6	0.1	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	0.5	0.1	-0.3	-0.2	-0.8
Medication: Blood pressure	0.1	0.2	1.1	-0.1	0.1	0.1	0.3	1.0
Medication: Seretide 50 evohaler	0.1	0.2	0.6	-0.1	0.8	-0.2	-0.4	-0.2
Mean time to correctly identify matches	0.1	0.2	0.6	0.6	0.8	-0.5	-0.4	-0.0
Heart disease (mother)	0.1	0.1	0.2	-0.5	0.3	0.1	0.1	0.3
Pulse rate, automated reading	0.1	0.4	0.7	-0.8	-0.8	0.5	-0.3	0.4
Friendships satisfaction	0.1	0.1	0.6	-0.1	-0.1	-0.8	-0.2	0.2
Osteoarthritis (self-reported)	0.1	0.2	0.5	0.2	-0.4	-0.7	-0.0	0.5
Mother’s age at death	0.1	0.1	0.4	-0.0	0.0	0.6	0.2	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	0.2	0.5	-0.3	-0.2	0.4
Illnesses of father: High blood pressure	0.1	0.2	0.6	0.4	-0.1	-0.2	0.1	0.8
Unable to work because of sickness or disability	0.1	0.1	0.4	0.6	0.2	-0.1	-0.2	-0.2
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.4	0.3	-0.4	0.4	0.6	0.3
LDL Cholesterol	0.0	0.1	0.2	-0.1	-0.3	0.1	0.5	-0.2
Neuroticism	0.0	0.1	0.1	0.4	-0.3	-0.2	-0.0	0.1
Sensitivity / hurt feelings	0.0	0.1	0.1	0.0	-0.2	-0.3	-0.2	-0.4
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	-0.3	0.0	-0.3	-0.0	0.0
Severe depression (siblings)	0.0	0.0	0.1	0.2	-0.3	-0.0	0.2	0.1
Current tobacco smoking	0.0	0.1	0.1	-0.4	0.3	-0.3	-0.2	-0.0
Medication: Cholesterol lowering	0.0	0.1	0.2	-0.0	0.3	-0.2	-0.4	-0.1
Lung cancer (father)	0.0	0.1	0.1	-0.3	-0.0	-0.2	0.4	-0.2
Medication: Omeprazole	0.0	0.1	0.2	0.2	0.1	-0.0	0.4	0.1
Smoking status: Current	0.0	0.1	0.2	-0.5	0.3	-0.2	-0.1	0.1
Medication: Lisinopril	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.3	0.2
Ever smoked	0.0	0.0	0.1	-0.3	0.0	0.3	0.2	0.1

Hub : Genes

RBL1

Models

Trait associations