Hub : Genes

RBM34

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0200	5.4e-04	0.056	0.027	0.046	0.037	0.049	2.0e-07	2.4e-04	2.8e-06	2.2e-05	1.1e-06
2	YFS	Blood	0.0269	0.0077	1.7e-06	0.023	0.021	0.016	0.021	0.018	4.3e-08	1.0e-07	4.2e-06	1.3e-07	1.4e-06
3	TCGA	Bladder Urothelial Carcinoma	0.0370	0.0200	1.1e-03	0.007	-0.003	-0.001	NA	-0.003	8.1e-02	8.3e-01	4.5e-01	NA	7.8e-01
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0347	0.0241	6.0e-03	0.011	0.016	0.023	NA	0.016	1.9e-02	6.1e-03	1.1e-03	NA	6.4e-03
5	TCGA	Pheochromocytoma and Paraganglioma	0.0870	0.0540	6.5e-03	-0.007	0.011	0.001	NA	-0.003	9.2e-01	1.1e-01	2.9e-01	NA	4.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.2	0.4	-0.1	0.6	-0.4	-0.4	-0.7
Bipolar Disorder or Schizophrenia	0.2	0.6	1.2	-0.9	0.3	-1.1	-1.0	-0.2
Depressed Affect (Nagel 2018)	0.6	1.3	2.4	-1.5	1.4	-0.9	0.7	-1.1
Depression (Nagel 2018)	2.2	3.3	4.6	-2.0	2.1	-1.8	-0.5	-2.1
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.0	1.3	-2.0	0.4	-1.4	1.9
Neuroticism (Nagel 2018)	1.4	3.2	5.4	-2.3	2.3	-1.4	0.4	-1.7
Schizophrenia (2018)	0.3	0.6	1.1	-1.0	-0.1	-1.0	-1.0	0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.3	0.4	-0.6	0.4	1.2	-0.3
Worry (Nagel 2018)	1.7	3.5	7.1	-1.8	2.7	-1.2	1.1	-2.2
Alzheimer’s Disease (in mother)	0.9	1.0	2.5	0.6	-1.6	1.1	0.2	1.0
Alzheimer’s Disease (in father)	0.6	0.6	1.5	0.5	-0.9	0.6	0.2	1.2
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	0.5	-1.4	0.9	0.4	1.2
Crohns Disease (2017)	1.1	2.4	3.1	-1.7	1.3	-1.7	-1.2	-1.8
Irritable Bowel Disease (IBD)	0.4	0.9	1.9	-0.6	0.8	-1.1	-0.7	-1.4
Ulcerative Colitis (UC)	0.1	0.2	0.5	0.5	-0.1	-0.3	-0.1	-0.7
Major Depression (MDD)	3.0	3.7	5.8	-2.4	1.5	-2.2	-2.0	-1.3
Reaction Time	0.4	0.8	1.3	1.2	-0.5	1.1	1.0	0.2
Verbal and Numeric Reasoning (VNR)	1.3	3.1	6.5	1.8	-2.6	1.1	-0.8	2.0
Breast Cancer	0.3	0.7	1.5	1.2	-0.1	1.0	1.0	0.3
Ovarian Cancer	0.3	0.4	0.9	0.7	-1.0	0.3	0.3	-0.5
Prostate Cancer	0.1	0.1	0.4	0.4	-0.6	0.1	-0.3	-0.2
Age at First Birth	0.4	0.6	2.5	0.4	0.7	-0.0	0.3	-1.6
Bipolar Disorder (2011)	1.0	1.0	3.0	1.4	-1.7	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.4	-1.1	-0.2	-1.0	-1.2	0.1
Coronary Artery Disease (CAD)	1.5	1.8	3.1	1.7	-1.8	1.3	0.2	1.1
Crohns Disease (2012)	0.6	1.0	2.3	-1.2	0.3	-1.5	0.0	-1.1
Mean Putamen Volume	0.6	0.7	1.1	0.8	-0.7	1.1	0.8	0.8
Fasting Glucose	0.2	0.2	0.6	-0.4	0.1	-0.8	0.4	-0.0
HbA1C	1.6	1.8	5.4	2.3	-0.3	1.1	1.5	0.4
HDL Cholesterol	0.3	0.5	1.3	-0.3	0.9	-0.2	0.3	-1.1
LDL Cholesterol	0.3	0.5	1.1	-0.1	-1.1	-0.2	-1.0	0.5
Lupus	2.0	3.0	8.9	-1.4	0.5	-1.9	-3.0	-0.3
Neuroticism (2016)	0.5	0.7	1.8	-0.1	-1.1	-0.5	-1.4	0.5
Primary Biliary Cirrhosis	0.2	0.2	0.5	-0.7	-0.5	-0.5	-0.3	0.4
Rheumatoid Arthritis	1.3	1.8	6.0	-0.1	1.6	0.5	2.4	-0.6
Schizophrenia (2014)	0.0	0.0	0.1	-0.3	-0.3	-0.2	0.2	-0.0
Triglycerides	0.0	0.0	0.1	0.0	0.2	-0.1	0.2	-0.1
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.2
Ulcerative Colitis	0.2	0.2	0.4	0.4	-0.5	-0.6	-0.3	-0.6
Blood Eosinophil Count	1.1	8.2	12.0	-3.3	2.6	-3.5	-3.0	-1.4
Blood Platelet Count	1.0	12.1	23.1	-4.8	2.0	-4.0	-4.1	-0.0
Blood Red Count	0.8	7.4	12.4	3.5	-3.2	3.1	1.5	1.6
Blood White Count	0.1	0.4	1.6	-0.3	1.3	0.2	-0.5	-0.3
Heel T-Score	0.5	4.2	9.4	0.7	3.1	1.0	2.4	-2.1
BMI	0.3	1.9	6.1	-0.6	-0.8	-1.4	-2.5	-0.1
Height	0.9	16.7	41.2	2.4	-5.5	2.4	-0.6	6.4
Waist Hip Ratio (WHR)	0.4	1.8	3.0	1.5	-1.7	1.3	1.4	-0.2
Systolic Blood Pressure	0.2	1.0	3.2	0.4	-1.8	-0.1	-0.9	1.0
Smoking Status	0.3	0.7	2.8	0.1	0.4	0.2	0.9	-1.7
Allergy or Eczema	0.1	0.2	0.4	0.5	-0.0	0.4	0.7	0.4
Cardiovascular Disease	0.3	0.9	2.1	-1.1	-0.6	-0.9	-1.4	-0.2
Hypothyroidism (self reported)	1.6	3.8	12.8	-1.1	-0.9	-1.8	-3.6	0.7
Respiratory disease	0.6	1.4	3.0	-1.7	0.1	-1.2	-1.5	0.1
Type 2 Diabetes (T2D) (2018)	0.7	1.4	5.0	0.6	-2.2	0.3	-0.4	1.1
Lung FEV1/FVC ratio	1.3	6.7	10.0	3.0	-2.4	3.2	1.9	2.2
Lung FVC	0.3	1.6	4.7	1.0	-2.2	1.0	-0.4	0.9
Neuroticism	0.5	1.1	1.6	-1.0	1.2	-0.6	1.1	-1.3
Chronotype (morning person)	0.1	0.2	0.8	-0.9	0.1	-0.4	0.3	0.3
Hair Pigment	0.1	4.0	6.2	1.5	-2.5	2.1	2.5	1.1
Tanning	0.2	2.1	3.0	-1.2	1.5	-1.4	-1.7	-1.3
Hand grip strength (left)	0.3	0.7	1.3	0.5	-0.3	0.9	-1.0	1.1
Number of treatments/medications taken	0.7	1.3	3.5	-0.2	-0.7	-1.3	-1.9	-1.0
Average weekly spirits intake	0.6	0.7	2.2	0.8	-1.5	0.0	-0.8	0.0
Sensitivity / hurt feelings	1.9	3.2	4.2	-2.0	2.0	-1.9	-0.3	-2.1
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.6	-1.9	1.4	-1.2	-0.5	-1.0
Hearing difficulty/problems: Yes	0.1	0.2	0.5	-0.3	0.4	-0.5	-0.1	-0.7
Relative age of first facial hair	0.7	1.4	2.7	-0.4	1.5	-0.0	1.7	-1.4
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.6	-0.4	-2.1	-1.0	-2.6	0.3
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.1	0.2	-1.0	-0.0	-0.6	0.4
Ever had hysterectomy (womb removed)	0.6	0.7	2.5	-0.1	-0.6	-0.4	-1.6	0.8
Systolic blood pressure, automated reading	0.2	0.6	2.1	0.3	-0.8	-0.6	-1.4	-0.1
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	0.7	-1.4	0.7	1.3	1.0
Angina	0.2	0.3	0.7	0.1	-0.9	-0.7	-0.1	-0.5
Medication for hormone replacement therapy	0.2	0.3	0.5	-0.7	-0.2	-0.5	-0.7	0.4
Vitamin and mineral supplements	0.1	0.1	0.4	0.3	0.1	0.1	0.6	-0.1
Supplements: Zinc	0.1	0.1	0.3	-0.5	-0.2	-0.1	-0.3	0.5
Medication: Co-codamol	0.1	0.1	0.2	-0.5	0.1	-0.4	-0.1	0.4
Medication: Metformin	0.3	0.4	1.9	0.2	-1.4	-0.0	0.2	0.2
Diabetes (father)	0.1	0.1	0.3	0.3	-0.1	-0.1	0.2	-0.5
Diabetes (mother)	1.2	1.6	4.1	-0.6	0.2	-1.2	-2.0	-1.4
Severe depression (siblings)	2.9	3.3	4.6	-1.8	1.3	-2.0	-2.2	-1.6
Pack years adult smoking proportion	0.2	0.3	0.6	-0.1	-0.4	-0.7	-0.7	-0.4
Impedance of leg (right)	0.8	4.1	14.5	1.0	1.0	1.9	3.8	-0.3
Leg fat-free mass (left)	0.7	3.7	10.5	-0.5	-1.9	-1.2	-3.2	1.6
Trunk fat percentage	0.2	0.7	1.8	-0.0	-0.2	-0.9	-1.3	-0.8
Hand grip strength (right)	0.9	2.4	5.4	1.0	-1.7	1.5	-0.7	2.3
Townsend deprivation index at recruitment	1.0	1.4	3.6	1.9	-0.2	1.4	1.1	-0.5
Current tobacco smoking	0.3	0.5	1.4	-0.5	0.6	-0.6	-0.5	-1.2
Average weekly fortified wine intake	0.9	1.0	4.2	0.1	-0.2	-0.9	-2.1	-0.2
Maternal smoking around birth	0.4	0.6	1.0	-0.9	0.6	-0.8	0.1	-1.0
Fed-up feelings	0.7	1.2	4.3	-0.9	0.8	0.0	2.1	-0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	3.9	-1.6	2.0	-1.6	-0.2	-2.0
Relative age voice broke	0.2	0.3	0.6	-0.1	0.8	0.1	0.7	-0.6
Taking other prescription medications	0.5	0.7	2.2	-0.1	-0.9	-0.8	-1.5	-0.2
Age when periods started (menarche)	0.9	2.2	4.4	-2.1	2.0	-0.8	1.4	-0.1
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.9	0.1	-1.7	-0.3	-1.7	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.2	1.8	0.3	2.3	2.2	0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.1	-0.6	0.9	-1.1	-0.7	-0.8
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.7	0.2	0.5	0.7	-0.1
Serious illness, injury or assault to yourself	0.2	0.3	0.5	0.6	-0.7	0.3	0.1	-0.5
High blood pressure	0.2	0.6	2.7	0.1	-0.2	-0.3	-1.6	0.1
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	-0.3	0.3	0.0	0.4	0.3
Multivitamins +/- minerals	0.1	0.1	0.1	0.1	-0.4	0.4	-0.0	-0.2
Stomach or abdominal pain in last month	1.0	1.2	2.1	-1.1	0.3	-1.3	-1.4	-1.0
Supplements: Glucosamine	0.6	0.8	1.5	0.1	-1.2	0.2	-1.1	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	0.8	-0.9	0.2	-0.9	-0.7	-0.5
Medication: Atenolol	0.0	0.1	0.1	-0.2	0.4	-0.1	0.1	0.3
Medication: Levothyroxine sodium	2.0	3.3	12.5	-0.6	-1.1	-1.4	-3.5	0.8
Sitting height	0.8	5.7	15.3	1.9	-2.3	2.1	0.1	3.9
Chronic bronchitis/emphysema (father)	0.5	0.5	1.8	0.6	0.2	-0.0	0.6	-1.4
High blood pressure (mother)	3.1	4.3	6.1	-1.8	1.8	-2.5	-2.1	-2.1
Body mass index (BMI)	0.7	3.1	7.3	-0.9	0.2	-2.1	-2.7	-1.7
Impedance of leg (left)	0.7	3.4	12.2	0.9	0.9	1.7	3.5	-0.4
Leg predicted mass (left)	0.7	3.8	11.0	-0.6	-1.9	-1.2	-3.3	1.6
Trunk fat mass	0.2	1.0	3.4	0.0	-0.9	-1.0	-1.9	-0.1
Waist circumference	0.5	1.9	6.1	-0.1	-0.9	-1.2	-2.5	-1.0
Number of incorrect matches in round	0.9	1.5	3.5	1.1	0.5	1.4	1.9	-0.6
Past tobacco smoking	0.2	0.4	1.3	0.3	-0.4	-0.2	-1.1	0.7
Alcohol usually taken with meals	0.2	0.4	0.9	-0.5	-0.2	-0.4	-0.9	0.7
Nervous feelings	2.5	4.6	10.4	-1.7	3.2	-1.2	1.1	-2.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	0.9	-1.0	0.5	-0.7	-0.4	-0.9
Hearing difficulty/problems with background noise	0.8	1.3	2.1	-1.3	0.9	-1.4	-1.4	-0.4
Hair/balding pattern: Pattern 2	1.2	1.5	2.9	-0.8	1.7	-0.4	1.0	-1.7
Had menopause	2.3	2.9	8.4	-1.2	0.0	-2.1	-2.9	-0.4
Had other major operations	0.6	0.7	2.3	-0.5	0.3	-0.8	-1.5	-0.5
Forced vital capacity (FVC)	2.9	11.2	20.9	2.5	-4.2	3.2	0.8	4.6
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	7.6	2.2	0.6	2.3	2.8	-0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	3.3	-0.7	1.7	-0.6	0.2	-1.8
Qualifications: None of the above	0.3	0.6	0.9	0.9	-0.9	0.7	0.9	-0.3
Financial difficulties in last 2 years	1.8	2.4	4.8	1.2	-1.5	1.8	2.2	0.3
Mouth/teeth dental problems	0.2	0.4	0.9	0.2	-0.0	0.9	0.8	0.5
Heart attack	0.8	1.1	2.8	-0.9	0.4	-1.2	-0.3	-1.7
Allergy	0.4	1.0	1.8	1.3	-1.1	1.0	0.7	0.6
Pain all over the body in last month	0.1	0.1	0.2	0.4	0.2	-0.1	0.0	-0.4
Diabetes (self-reported)	0.6	0.9	2.5	0.5	-1.6	0.6	0.3	1.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.7	0.2	1.3	0.5	1.1	-0.1
Medication: Ramipril	0.3	0.4	1.2	0.1	0.2	-0.5	-0.7	-1.1
Medication: Simvastatin	1.5	2.2	8.1	-0.3	-1.3	-0.9	-2.8	0.4
Fluid intelligence score	0.4	0.8	1.5	0.4	-1.0	0.1	-1.2	1.2
Illnesses of siblings	0.1	0.1	0.2	0.4	-0.4	0.4	0.1	0.4
Neuroticism score	1.1	2.3	4.1	-1.8	2.0	-0.8	1.2	-1.5
Weight	0.6	2.9	10.1	-0.6	-1.3	-1.6	-3.2	0.3
Impedance of arm (right)	0.4	1.8	4.3	0.9	0.4	1.7	2.1	1.0
Arm fat percentage (right)	0.3	1.0	3.1	-0.1	-0.1	-1.0	-1.8	-1.0
Trunk fat-free mass	0.6	3.5	7.8	-0.3	-2.3	-0.8	-2.8	1.8
Hip circumference	0.6	2.6	9.5	-0.7	-0.5	-1.6	-3.1	-0.2
Time employed in main current job	0.8	1.0	1.4	-0.9	0.8	-1.1	-1.2	-0.9
Alcohol intake versus 10 years previously	0.3	0.4	0.8	-0.6	0.6	-0.4	0.9	-0.7
Father’s age at death	1.2	1.6	3.2	0.9	-0.3	1.5	1.2	1.8
Worrier / anxious feelings	0.3	0.5	1.3	-1.1	-0.0	-0.7	-0.8	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.4	1.9	-1.0	1.2	-1.4	-1.0	-1.2
Falls in the last year	0.3	0.4	1.0	-0.6	0.6	-0.7	-0.0	-1.0
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	-0.6	-0.4	0.2	0.8	0.5
Number of live births	2.1	2.9	3.6	-1.9	1.6	-1.8	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1)	3.7	12.4	24.0	2.7	-4.5	3.2	0.3	4.9
Pulse rate	0.1	0.1	0.3	-0.0	-0.2	-0.0	-0.3	-0.6
Happiness	1.1	1.4	2.5	-1.3	1.5	-0.5	0.4	-1.6
Noisy workplace	1.3	1.6	3.5	1.2	-0.6	1.6	1.9	0.3
Qualifications: A levels/AS levels or equivalent	1.0	2.1	5.0	0.5	-1.5	1.4	1.0	2.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.3	0.9	-0.6	-0.7	-0.6
Mouth/teeth dental problems: Dentures	1.0	1.6	2.9	-0.4	1.4	-1.3	-1.2	-1.7
Asthma	1.0	1.9	3.7	-1.9	0.4	-1.5	-1.8	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.4	-0.1	-0.3	-0.5	-0.4	-0.6
Medication: Cholesterol lowering	0.4	0.6	1.2	-0.3	-1.1	-0.9	-0.8	-0.3
Depression (self-reported)	0.1	0.2	0.6	-0.8	0.3	-0.3	-0.2	-0.2
Medication: Lansoprazole	2.7	3.0	6.2	1.9	-2.5	1.4	-1.1	1.5
Prospective memory result	0.1	0.2	0.3	0.5	0.4	-0.3	-0.6	-0.2
Lung cancer (father)	0.9	1.0	2.3	1.4	-1.5	0.8	0.2	-0.0
Illnesses of mother	1.6	1.9	3.6	1.2	-0.7	1.7	1.9	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.8	12.2	22.5	2.8	-4.1	3.4	1.3	4.7
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.6	0.3	-0.5	0.2	-0.5
Impedance of arm (left)	0.4	1.9	3.9	1.0	0.0	1.7	2.0	1.3
Arm fat mass (right)	0.5	2.2	7.2	-0.6	-0.4	-1.7	-2.7	-0.8
Trunk predicted mass	0.6	3.5	8.1	-0.4	-2.3	-0.9	-2.8	1.8
Standing height	0.7	7.1	20.2	0.7	-3.4	1.0	-1.4	4.5
Length of working week for main job	1.6	1.7	2.1	-1.3	1.4	-1.2	-1.1	-1.4
Exposure to tobacco smoke at home	0.2	0.2	0.8	-0.0	0.2	-0.3	-0.0	-0.9
Breastfed as a baby	1.2	1.5	3.6	1.0	-1.0	1.2	0.3	1.9
Tense / ‘highly strung’	1.3	2.2	5.6	-1.3	1.7	-1.0	-0.1	-2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.1	5.2	-2.2	2.1	-2.1	-1.3	-2.3
Hair/balding pattern: Pattern 4	0.7	1.6	3.1	1.3	-1.4	0.9	-0.5	1.8
Birth weight of first child	0.4	0.6	1.3	1.1	-0.8	0.9	0.5	0.5
Peak expiratory flow (PEF)	4.6	10.7	20.9	2.2	-4.4	2.9	0.1	4.6
Pulse wave reflection index	0.3	0.3	0.7	-0.6	0.8	-0.1	0.8	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.2	0.3	0.2	0.5	-0.2	-0.3	-0.5
Loud music exposure frequency	0.6	0.7	2.0	-0.4	0.6	-0.0	1.4	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	0.5	0.1	1.0	0.8	1.5
Mouth/teeth dental problems: Bleeding gums	1.3	1.6	3.4	-1.8	1.1	-1.6	-0.2	-1.1
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.2	0.4	-0.5	-0.7	-0.7
Medication: Paracetamol	0.4	0.6	1.3	-0.8	1.2	-0.8	-0.1	-0.7
Headache pain in last month	0.2	0.4	0.9	-0.9	0.8	-0.4	0.7	-0.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	1.7	0.5	-0.4	1.3	1.2	1.3
Glaucoma (self-reported)	0.2	0.3	0.4	-0.5	0.5	-0.6	-0.4	-0.5
Gout (self-reported)	0.2	0.3	0.9	0.4	-1.0	-0.1	-0.3	0.4
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	7.3	-0.3	-1.5	-1.0	-2.7	0.8
Medication: Amlodipine	2.9	4.1	6.8	-1.7	1.6	-2.3	-2.6	-1.7
Medication: Ventolin 100micrograms inhaler	0.8	1.0	3.6	-1.9	0.7	-1.0	-0.1	0.1
Birth weight	1.8	4.0	6.6	1.9	-2.6	1.9	0.7	2.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.1	0.4	-1.7	0.8	1.4	1.2
High blood pressure (siblings)	0.2	0.3	0.4	-0.6	0.6	-0.4	0.3	-0.6
Forced vital capacity (FVC), Best measure	2.2	7.9	15.8	2.0	-3.3	2.7	1.2	4.0
Body fat percentage	0.2	0.8	1.7	-0.0	0.2	-0.9	-1.2	-1.3
Leg fat percentage (right)	0.3	1.2	4.5	0.1	0.8	-0.9	-0.5	-2.1
Arm fat-free mass (right)	0.6	3.2	9.3	-0.5	-1.9	-1.2	-3.0	1.0
Exposure to tobacco smoke outside home	1.0	1.3	5.1	0.4	1.1	-0.1	-0.4	-2.3
Comparative body size at age 10	0.8	2.3	3.2	-1.5	1.1	-1.8	-1.5	-1.6
Number of full brothers	0.4	0.5	2.0	-0.8	1.4	-0.1	0.0	0.2
Worry too long after embarrassment	0.3	0.5	1.1	-1.0	0.8	-0.5	0.1	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	-1.0	0.5	-0.5	-0.2	-0.9
Wheeze or whistling in the chest in last year	0.6	1.0	2.6	-0.7	0.7	-1.1	-0.5	-1.6
Number of children fathered	0.9	1.0	2.6	0.5	-1.1	1.0	0.4	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.6	-1.3	0.6	-0.9	-0.5	-0.2
Age at first live birth	0.4	0.7	1.2	0.5	-0.4	0.9	1.0	1.1
Pulse wave peak to peak time	0.2	0.3	0.5	0.6	-0.4	0.6	-0.3	0.7
Health satisfaction	0.5	0.7	2.6	0.2	0.5	0.7	1.6	-0.5
Shortness of breath walking on level ground	0.2	0.2	0.4	0.0	-0.6	-0.3	-0.7	-0.1
Qualifications: College or University degree	0.6	1.9	4.9	-1.4	-0.6	-1.0	-2.2	1.1
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.2	0.5	0.6	0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	-0.4	1.0	-0.9	-0.5	-0.9
Emphysema/chronic bronchitis	0.2	0.3	1.3	-0.0	-1.1	-0.1	-0.1	0.1
Medication for pain relief, constipation, heartburn	0.7	1.1	4.5	-0.1	-0.4	1.0	0.2	2.1
Neck or shoulder pain in last month	0.3	0.4	0.9	0.0	-0.5	0.2	0.9	-0.8
Medication: Blood pressure	0.2	0.4	0.8	-0.1	0.5	-0.7	-0.9	-0.8
Angina (self-reported)	0.2	0.3	0.6	-0.1	-0.6	-0.8	-0.2	-0.8
Migraine (self-reported)	0.4	0.5	1.4	0.5	-0.5	0.7	1.2	0.1
Medication: Ibuprofen	0.2	0.3	0.7	0.7	-0.9	0.2	-0.4	0.1
Medication: Allopurinol	0.2	0.3	0.8	0.8	-0.9	0.1	-0.3	0.1
Medication: Omeprazole	1.1	1.3	3.2	-0.8	-0.2	-1.4	-1.8	-0.7
Medication: Seretide 50 evohaler	0.8	0.9	1.6	-1.2	0.7	-1.3	-0.6	-0.6
Mean time to correctly identify matches	0.2	0.3	0.9	0.9	-0.6	0.4	0.4	-0.4
Heart disease (mother)	0.8	0.9	2.1	-0.5	0.1	-1.0	-1.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.4	-0.3	0.3	-0.0	0.1	0.7
Whole body fat mass	0.3	1.3	4.5	-0.3	-0.4	-1.2	-2.1	-0.6
Leg fat mass (right)	0.3	1.2	2.8	-0.4	-0.1	-1.3	-1.7	-1.2
Arm predicted mass (right)	0.6	2.9	8.4	-0.6	-1.9	-1.2	-2.9	1.0
Pulse rate, automated reading	1.1	3.6	5.0	-1.8	1.2	-2.1	-1.9	-2.2
Alcohol intake frequency.	0.2	0.4	1.0	-1.0	0.5	-0.7	0.0	-0.1
Comparative height size at age 10	0.8	4.6	10.4	1.3	-3.2	1.0	-1.0	3.0
Number of full sisters	0.1	0.1	0.2	0.1	-0.4	0.3	0.3	0.4
Suffer from ‘nerves’	3.8	6.0	12.7	-2.6	3.6	-1.6	0.9	-2.7
Overall health rating	1.0	2.2	3.4	-1.5	0.9	-1.8	-1.1	-1.8
Chest pain or discomfort	0.9	1.2	2.7	-0.8	1.1	-1.1	-0.7	-1.6
Had major operations	3.1	3.6	9.0	-1.3	0.7	-2.0	-3.0	-1.7
Age at last live birth	0.0	0.1	0.2	-0.0	0.4	0.2	0.2	-0.2
Family relationship satisfaction	0.4	0.5	1.2	0.6	0.2	0.8	1.1	-0.4
Leg pain on walking	0.1	0.1	0.5	-0.7	0.3	-0.3	-0.2	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.0	1.7	-0.4	1.3	1.4	-0.4
Commuting to job workplace: Car/motor vehicle	0.6	0.6	1.0	-1.0	1.0	-0.7	-0.2	-0.9
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	2.2	-1.5	1.4	-1.5	-0.9	-0.8
Medication: Aspirin	1.0	1.4	5.0	0.1	0.5	-1.2	-0.4	-2.2
Supplements: Vitamin C	0.2	0.2	0.6	0.2	0.1	0.6	0.8	0.2
Knee pain experienced in last month	0.1	0.2	0.6	-0.8	-0.6	-0.3	0.2	-0.2
Hypertension (Self-reported)	0.3	0.9	3.3	-0.7	0.4	-0.9	-1.8	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.8	0.1	-0.8	-0.4	-0.9	0.2
Illnesses of father: Heart disease	0.4	0.5	1.4	0.8	-1.2	0.4	0.7	-0.2
Illnesses of siblings: Diabetes	0.4	0.4	1.5	0.6	-1.2	0.2	-0.5	0.4
Smoking status: Previous	0.2	0.3	0.9	-0.2	0.1	0.1	0.9	-0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.6	0.2	-1.5	0.9	0.8	1.9
Whole body fat-free mass	0.7	3.9	10.8	-0.6	-2.1	-1.2	-3.3	1.6
Leg fat-free mass (right)	0.9	4.6	13.8	-0.8	-2.0	-1.5	-3.7	1.7
Arm fat percentage (left)	0.3	1.1	3.2	-0.1	-0.1	-1.1	-1.8	-1.0
Average weekly red wine intake	0.2	0.2	0.6	-0.5	0.7	0.1	-0.4	0.4
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.8	-0.7	1.7	-0.6	0.2	-1.6
Mood swings	1.8	3.3	7.0	-1.8	2.6	-1.4	0.1	-2.0
Loneliness, isolation	1.4	2.0	4.9	-2.2	1.4	-1.3	-0.5	-1.0
Long-standing illness, disability or infirmity	2.0	3.1	8.8	-0.9	-1.3	-1.9	-3.0	-0.7
Ever had bowel cancer screening	1.3	1.5	3.0	-1.0	0.8	-1.6	-0.7	-1.7
Diabetes diagnosed by doctor	0.3	0.5	2.0	0.4	-1.4	0.1	-0.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.1	0.4	0.6	0.8	-0.2
Friendships satisfaction	2.0	2.5	5.2	1.6	-0.8	2.0	2.3	0.4
Qualifications: nursing, teaching	0.3	0.5	1.1	0.5	-0.8	0.6	0.3	1.0
Commuting to job workplace: Walk	1.0	1.0	1.9	0.6	-1.4	-0.0	-1.2	1.2
Eye problems/disorders: Cataract	0.3	0.3	0.7	0.7	-0.5	0.5	0.9	0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.3	1.0	-1.6	1.2	1.0	1.8
Medication for cholesterol	0.9	1.4	5.4	0.5	0.5	0.9	2.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.0	1.4	-1.0	0.5	-0.8	0.1
Back pain experienced in last month	1.5	2.1	3.3	-1.6	0.4	-1.8	-1.7	-1.3
Mineral and other dietary supplements	0.5	0.7	2.6	0.6	0.1	0.8	1.6	-0.1
Breast cancer (self-reported)	1.1	1.3	2.2	-1.4	1.2	-1.5	-0.2	-0.9
Asthma (self-reported)	1.0	2.0	4.5	-2.1	0.5	-1.6	-1.7	-0.4
Osteoporosis (self-reported)	0.2	0.2	1.1	0.1	-1.0	-0.0	-0.2	0.1
Osteoarthritis (self-reported)	0.7	0.9	2.2	0.8	-1.5	0.9	0.3	0.9
Medication: Aspirin	0.7	0.9	3.1	-0.1	0.2	-1.2	-0.4	-1.7
Medication: Gliclazide	1.2	1.3	2.6	-1.3	0.2	-1.5	-1.6	-0.5
Illnesses of father: None of the above (group 1)	0.6	0.7	1.5	-1.0	1.2	-0.8	-0.7	-0.3
Smoking status: Current	0.3	0.5	0.8	-0.7	0.6	-0.6	-0.6	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.5	7.4	11.2	3.4	-2.6	3.3	2.1	1.9
Whole body water mass	0.7	4.0	10.8	-0.6	-2.2	-1.2	-3.3	1.7
Leg predicted mass (right)	0.9	4.6	13.8	-0.8	-1.9	-1.5	-3.7	1.6
Arm fat mass (left)	0.5	2.2	7.1	-0.6	-0.4	-1.7	-2.7	-0.9
Number of self-reported non-cancer illnesses	0.8	1.3	4.7	-0.5	-0.5	-1.2	-2.2	-0.3
Average weekly champagne plus white wine intake	1.4	1.9	4.5	-1.3	-0.4	-1.1	-2.1	1.4
Miserableness	0.2	0.4	1.4	-0.7	0.4	0.2	1.2	0.3
Guilty feelings	0.3	0.4	1.3	-1.1	0.9	-0.2	0.3	-0.0
Wears glasses or contact lenses	1.3	1.5	2.4	-1.6	1.3	-1.4	-1.1	-0.3
Ever taken oral contraceptive pill	0.9	1.0	3.1	-0.9	0.6	-0.2	1.8	-0.8
Hearing aid user	0.1	0.1	0.2	-0.2	0.2	0.0	0.4	0.2
Mother’s age at death	1.2	1.5	4.2	1.0	-1.0	1.1	-0.6	2.0
Financial situation satisfaction	0.7	0.9	2.1	-0.7	0.6	0.2	1.4	-1.1
Tinnitus: Yes, now most or all of the time	1.6	1.8	3.1	1.1	-1.3	1.7	0.4	1.8
Commuting to job workplace: Public transport	0.2	0.2	0.6	-0.3	-0.1	-0.3	-0.7	0.6
Eye problems/disorders: Glaucoma	1.5	1.7	3.0	-1.1	1.0	-1.6	-1.7	-1.0
Medication: Blood pressure	0.4	0.8	2.9	-0.1	-0.6	-0.4	-1.7	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.7	-0.9	-0.5	-0.4	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.5	-0.4	0.4	0.1	0.1
High cholesterol (Self-reported)	0.4	0.7	1.7	0.1	-1.3	-0.7	-1.1	-0.5
Medication: Bendroflumethiazide	1.1	1.6	3.6	-1.0	1.1	-1.3	-1.9	-0.8
Medication: Paracetamol	0.1	0.1	0.5	-0.2	-0.0	-0.3	-0.7	0.3
Medication: Lisinopril	0.4	0.5	1.5	-1.2	-0.2	-0.8	-0.5	0.2
Medication: Atorvastatin	0.3	0.3	0.7	-0.4	-0.3	-0.8	0.3	-0.8
Illnesses of father: High blood pressure	1.5	1.9	4.9	-2.2	1.8	-1.2	0.1	-0.2
Alcohol drinker status: Never	3.4	4.1	11.4	-2.1	0.1	-2.2	-3.4	-0.2
Ever smoked	0.2	0.4	1.0	-0.6	0.8	-0.3	0.0	-1.0
Basal metabolic rate	0.7	3.6	10.6	-0.7	-1.9	-1.4	-3.3	1.3
Leg fat percentage (left)	0.4	1.5	4.7	-0.1	0.9	-1.1	-0.8	-2.2
Arm fat-free mass (left)	0.5	2.7	8.6	-0.6	-1.6	-1.4	-2.9	0.6
Number of operations (self-reported)	0.8	1.1	4.0	-0.4	0.1	-1.1	-2.0	-0.6
Average weekly beer plus cider intake	0.8	1.2	1.8	1.1	-1.3	1.2	0.0	1.4
Irritability	0.2	0.3	0.8	-0.5	-0.5	-0.4	-0.9	0.4
Risk taking	0.3	0.4	0.8	0.2	-0.9	0.5	-0.8	0.7
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	0.3	-0.4	0.6	0.6	0.6
Fractured/broken bones in last 5 years	1.9	2.5	5.7	-1.6	-0.0	-2.0	-2.4	-0.6
Age started oral contraceptive pill	0.9	1.2	4.3	0.0	-0.9	-0.8	-2.1	-0.2
Diastolic blood pressure, automated reading	0.1	0.4	1.0	0.6	0.5	0.2	0.4	-1.0
Ever depressed for a whole week	2.4	2.9	4.0	-2.0	2.0	-1.7	-0.7	-1.8
Unable to work because of sickness or disability	0.8	1.0	1.5	1.2	-1.2	1.2	0.6	0.5
Commuting to job workplace: Cycle	0.5	0.6	1.1	0.4	-1.0	0.8	-0.2	1.0
Myopia	0.7	1.1	2.6	-1.6	1.4	-0.9	-0.4	0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.3	-0.2	0.4	0.5	1.8	0.2
Cholesterol lowering medication	0.8	1.2	4.2	-0.5	-0.9	-0.8	-2.1	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.9	0.1	-0.5	-0.6	-0.8	-1.0
Pain experienced in last month	0.8	1.3	2.2	1.5	-0.1	1.4	1.2	1.0
Supplements: Calcium	1.3	1.4	3.1	-0.8	1.1	-1.3	-1.8	-0.6
Basal cell carcinoma (self-reported)	1.6	1.9	3.8	0.7	-1.7	1.3	0.8	1.9
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.5	-1.0	0.5	-1.3	-0.4	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.6	-0.5	0.7	-0.9	-1.2	-1.0
Heart disease (siblings)	0.3	0.4	1.3	0.1	-0.8	0.3	0.1	1.1
Alcohol drinker status: Previous	0.2	0.3	0.6	0.4	0.4	0.6	0.8	0.1
Pack years of smoking	0.2	0.3	0.5	-0.1	-0.4	-0.7	-0.7	-0.4
Impedance of whole body	0.6	2.8	8.9	1.0	0.6	1.9	3.0	0.5
Leg fat mass (left)	0.4	1.6	3.7	-0.5	-0.1	-1.5	-1.9	-1.2
Arm predicted mass (left)	0.5	2.6	8.1	-0.4	-1.6	-1.2	-2.9	0.8