Hub : Genes

RBM39

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.0748	0.0372	0.0034	0.012	NA	0.017	NA	0.021	4.3e-02	NA	2.2e-02	NA	1.2e-02
2	METSIM	Adipose	0.0364	0.0185	0.0051	0.023	0.016	0.006	0.016	0.015	1.7e-04	1.5e-03	3.4e-02	1.6e-03	2.1e-03
3	YFS	Blood	0.0501	0.0166	0.0000	0.047	0.061	0.058	0.060	0.055	5.2e-15	2.6e-19	3.1e-18	4.5e-19	1.9e-17
4	TCGA	Esophageal Carcinoma	0.1830	0.1240	0.0027	0.087	0.104	0.135	NA	0.116	1.0e-03	3.4e-04	4.6e-05	NA	1.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	0.9	1.3	1.1	-1.0	0.8	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.4	0.9	0.9	-0.5	0.4	-0.5
Depressed Affect (Nagel 2018)	0.1	0.3	0.7	-0.3	-0.2	0.5	-0.8
Depression (Nagel 2018)	0.9	1.3	2.2	-1.0	-0.3	1.5	-1.4
Intelligence (Savage-Jansen 2018)	7.1	21.9	38.4	-3.2	4.3	6.2	-4.5
Neuroticism (Nagel 2018)	0.1	0.4	1.0	-1.0	0.0	0.0	0.7
Schizophrenia (2018)	0.0	0.0	0.1	0.2	0.2	-0.2	0.1
Schizophrenia vs Biploar Disorder	2.5	3.3	4.9	-0.2	-1.9	-2.2	2.2
Worry (Nagel 2018)	0.4	0.9	1.5	-1.1	1.2	1.0	0.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.6	0.3	1.0	-1.6	1.1
Alzheimer’s Disease (in father)	1.3	1.4	3.6	1.9	0.2	-1.4	-0.0
Alzheimer’s Disease (including proxy)	1.4	2.0	5.1	1.2	0.2	-2.3	1.2
Crohns Disease (2017)	0.2	0.5	0.9	-0.9	-1.0	-0.3	0.4
Irritable Bowel Disease (IBD)	0.5	1.2	2.7	-1.6	-1.4	0.4	0.1
Ulcerative Colitis (UC)	0.7	1.2	3.1	-1.8	-1.1	0.5	-0.6
Major Depression (MDD)	0.7	0.8	1.4	1.2	-1.0	-0.9	0.3
Reaction Time	2.7	5.1	11.8	3.4	-1.2	-2.7	0.2
Verbal and Numeric Reasoning (VNR)	3.3	7.9	15.5	-2.3	2.2	3.9	-2.5
Breast Cancer	1.1	2.5	9.9	0.0	3.1	-0.5	0.3
Ovarian Cancer	0.3	0.4	1.1	0.6	0.5	-1.1	0.1
Prostate Cancer	0.9	1.2	2.2	-0.6	-1.5	-1.1	1.1
Age at First Birth	2.2	3.2	7.1	-1.9	1.2	-0.6	2.7
Bipolar Disorder (2011)	0.3	0.3	0.5	0.1	0.7	0.7	0.1
Body Mass Index (BMI) (2010)	1.1	1.5	4.5	1.1	0.1	0.4	-2.1
Coronary Artery Disease (CAD)	1.1	1.3	2.3	1.0	-1.5	0.6	-1.3
Crohns Disease (2012)	0.2	0.4	1.0	-0.6	0.1	0.4	-1.0
Mean Putamen Volume	1.0	1.1	3.0	-0.8	1.7	0.8	0.5
Fasting Glucose	0.7	0.8	1.9	-0.3	1.4	1.0	0.4
HbA1C	0.7	0.8	2.9	1.7	-0.5	-0.1	-0.2
HDL Cholesterol	2.9	4.9	10.5	0.9	-0.8	-3.2	2.8
LDL Cholesterol	3.1	4.8	10.7	1.4	-0.8	-3.3	2.4
Lupus	0.8	1.2	4.0	-2.0	0.3	0.9	0.1
Neuroticism (2016)	0.3	0.4	1.3	-0.2	-0.3	0.2	-1.2
Primary Biliary Cirrhosis	0.8	1.2	3.7	0.7	-0.5	0.6	-1.9
Rheumatoid Arthritis	0.7	1.0	2.2	-1.5	-0.5	0.4	1.2
Schizophrenia (2014)	0.0	0.0	0.1	0.3	0.1	0.1	-0.1
Triglycerides	0.4	0.6	1.3	0.7	0.1	-1.1	-0.9
Type 2 Diabetes (T2D) (2012)	1.4	1.7	2.9	-1.4	0.2	1.7	-1.3
Ulcerative Colitis	1.7	2.4	2.8	-1.6	-1.3	1.7	-1.6
Blood Eosinophil Count	1.0	8.0	18.6	1.0	1.1	3.4	-4.3
Blood Platelet Count	0.5	5.4	13.8	-2.1	1.6	3.7	-0.9
Blood Red Count	0.9	8.4	22.8	2.9	4.8	-0.5	-1.3
Blood White Count	0.2	1.7	5.9	2.4	0.6	-0.7	-0.3
Heel T-Score	0.3	2.8	5.8	1.5	1.7	0.5	-2.4
BMI	0.8	4.4	9.9	1.8	-1.5	1.4	-3.1
Height	18.1	349.4	645.2	-25.4	1.0	24.5	-12.3
Waist Hip Ratio (WHR)	0.3	1.4	2.2	1.3	-1.0	-1.5	0.9
Systolic Blood Pressure	0.5	2.5	4.4	-1.4	1.6	2.1	-0.9
Smoking Status	1.0	2.4	3.1	1.0	-1.7	-1.8	1.6
Allergy or Eczema	0.9	2.5	3.3	-1.5	1.8	1.7	-1.1
Cardiovascular Disease	0.6	2.0	5.6	2.4	0.8	0.0	-1.3
Hypothyroidism (self reported)	0.8	1.8	4.0	0.8	-2.0	-0.7	1.4
Respiratory disease	1.0	2.1	3.3	-1.8	-1.5	1.8	-0.2
Type 2 Diabetes (T2D) (2018)	1.4	2.7	5.2	-1.4	0.5	2.3	-1.8
Lung FEV1/FVC ratio	1.2	6.0	12.3	-3.5	-0.3	3.1	-1.4
Lung FVC	8.2	41.8	74.1	6.3	-3.5	-8.6	6.4
Neuroticism	0.4	0.9	1.5	-1.0	0.1	1.2	-1.0
Chronotype (morning person)	0.6	1.4	3.3	-1.8	-0.6	1.0	0.9
Hair Pigment	3.9	110.1	233.0	10.2	9.6	-15.3	3.4
Tanning	7.8	95.4	166.4	-11.0	-9.7	12.9	-0.6
Hand grip strength (left)	4.4	11.6	27.1	-5.2	1.1	3.9	-1.7
Number of treatments/medications taken	0.6	1.0	2.6	1.6	-1.0	0.0	-0.8
Average weekly spirits intake	1.8	2.2	3.3	0.9	-1.7	-1.8	1.3
Sensitivity / hurt feelings	4.4	7.5	12.0	0.2	-2.9	-3.5	3.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.3	-0.2	-1.1	0.6	-1.1
Hearing difficulty/problems: Yes	0.9	1.4	3.2	-0.9	0.7	-0.9	1.8
Relative age of first facial hair	2.4	5.0	7.5	-0.1	-2.2	-2.7	2.7
Other serious medical condition/disability diagnosed by doctor	2.7	3.6	6.7	1.3	-2.6	-1.9	1.5
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.1	1.8	-0.4	-0.3	0.2
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	0.7	0.4	-0.6	1.0
Systolic blood pressure, automated reading	0.1	0.4	0.8	-0.2	0.9	0.7	-0.5
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	4.9	-2.2	0.3	1.7	-1.0
Angina	0.5	0.6	2.5	-0.3	-1.6	0.0	-0.0
Medication for hormone replacement therapy	0.7	0.8	1.6	1.1	-0.7	-0.2	1.3
Vitamin and mineral supplements	0.6	0.8	2.2	-0.3	0.8	0.3	-1.5
Supplements: Zinc	0.5	0.6	1.4	-0.3	0.6	1.2	-0.6
Medication: Co-codamol	0.8	0.9	2.9	1.7	-0.8	-0.2	-0.4
Medication: Metformin	2.0	2.9	5.4	-1.4	0.5	2.3	-2.0
Diabetes (father)	1.6	1.9	4.2	-0.1	-0.2	2.0	-1.9
Diabetes (mother)	1.9	2.5	7.7	1.0	-0.2	1.1	-2.8
Severe depression (siblings)	0.1	0.1	0.3	0.1	-0.2	-0.5	0.1
Pack years adult smoking proportion	0.7	1.0	2.4	0.0	-1.1	0.6	-1.6
Impedance of leg (right)	3.2	15.4	27.9	5.0	1.7	-5.3	2.4
Leg fat-free mass (left)	13.0	68.8	125.4	-10.5	-0.6	11.2	-6.3
Trunk fat percentage	0.6	2.6	6.6	1.8	-0.7	-0.1	-2.6
Hand grip strength (right)	7.2	19.6	39.3	-6.3	1.4	5.5	-2.6
Townsend deprivation index at recruitment	3.0	4.2	6.9	0.7	-2.6	-1.9	2.5
Current tobacco smoking	1.6	2.7	7.4	1.0	-2.7	-1.5	0.4
Average weekly fortified wine intake	0.2	0.2	0.5	-0.2	0.7	-0.2	-0.6
Maternal smoking around birth	0.7	1.0	2.4	0.7	-1.6	-0.9	0.3
Fed-up feelings	0.6	1.0	2.3	0.2	-1.3	0.4	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.9	-0.5	-1.0	0.4	-0.9
Relative age voice broke	2.8	4.2	8.9	-0.1	-0.5	-2.8	3.0
Taking other prescription medications	0.2	0.3	0.6	0.5	-0.5	0.5	-0.8
Age when periods started (menarche)	2.5	6.0	16.0	-4.0	1.0	0.3	2.6
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-0.1	-0.7	-0.8	1.1
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.8	10.0	0.7	3.2	1.8	-2.3
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.4	0.0	-0.8	0.8
Qualifications: CSEs or equivalent	3.6	4.8	9.0	2.3	-1.2	-3.0	1.9
Serious illness, injury or assault to yourself	0.3	0.3	0.9	0.3	-1.0	-0.4	-0.1
High blood pressure	0.1	0.3	1.0	1.0	-0.2	-0.2	-0.3
Hayfever, allergic rhinitis or eczema	0.8	1.7	2.7	-1.6	1.6	1.0	-0.6
Multivitamins +/- minerals	0.1	0.1	0.2	-0.3	-0.3	0.4	0.3
Stomach or abdominal pain in last month	0.4	0.5	1.5	1.2	-0.5	-0.3	-0.2
Supplements: Glucosamine	0.9	1.1	3.3	0.2	-0.1	-1.1	1.8
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	3.8	1.7	-2.0	-1.9	1.6
Medication: Atenolol	0.9	1.2	2.9	-1.7	-1.3	0.3	-0.3
Medication: Levothyroxine sodium	0.3	0.4	1.2	0.4	-1.1	0.2	0.6
Sitting height	24.8	176.2	313.3	-17.7	2.8	17.5	-8.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.2	0.3	-0.6	-0.8
High blood pressure (mother)	0.1	0.1	0.3	-0.4	-0.1	0.6	-0.0
Body mass index (BMI)	0.7	3.0	6.7	1.9	-1.2	0.5	-2.6
Impedance of leg (left)	3.1	15.3	28.9	4.9	1.3	-5.4	2.5
Leg predicted mass (left)	12.8	68.1	123.2	-10.5	-0.7	11.1	-6.2
Trunk fat mass	2.1	8.9	17.8	-2.1	-0.6	3.6	-4.2
Waist circumference	2.0	7.5	15.5	-1.3	-1.0	3.4	-3.9
Number of incorrect matches in round	1.4	2.3	3.2	1.6	0.8	-1.6	1.8
Past tobacco smoking	2.0	3.6	7.6	-1.0	0.9	2.3	-2.8
Alcohol usually taken with meals	4.5	7.2	13.1	-2.5	2.4	3.6	-1.8
Nervous feelings	0.2	0.4	1.4	-0.3	-0.4	-0.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	1.4	-1.2	0.2	-0.7
Hearing difficulty/problems with background noise	0.4	0.7	1.4	-1.1	0.1	-0.5	1.2
Hair/balding pattern: Pattern 2	0.6	0.7	2.1	1.4	0.7	-0.5	0.2
Had menopause	1.1	1.3	3.3	-0.8	0.9	1.8	-0.7
Had other major operations	0.2	0.2	0.4	-0.4	-0.6	-0.5	0.3
Forced vital capacity (FVC)	1.7	6.7	16.2	-4.0	-0.8	3.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.3	6.3	0.6	2.5	1.8	-1.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	0.4	-1.4	-0.2	-0.2
Qualifications: None of the above	3.6	7.6	11.5	2.5	-2.9	-3.4	2.1
Financial difficulties in last 2 years	0.9	1.2	3.6	0.8	-1.9	-0.1	-0.9
Mouth/teeth dental problems	1.2	1.8	2.5	-1.6	1.5	1.5	0.1
Heart attack	0.1	0.1	0.3	0.6	0.1	-0.2	0.2
Allergy	0.7	1.7	3.5	1.9	-0.4	-1.5	0.9
Pain all over the body in last month	0.6	0.6	2.2	0.3	-1.5	-0.5	-0.1
Diabetes (self-reported)	3.5	5.4	10.4	-1.2	0.6	3.1	-3.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.7	-2.2	0.4	1.0	-0.3
Medication: Ramipril	1.9	2.5	3.0	-1.6	1.3	1.5	-1.7
Medication: Simvastatin	0.7	1.1	2.8	0.4	1.7	-0.7	-1.0
Fluid intelligence score	4.7	9.7	20.2	-1.4	2.8	4.5	-3.0
Illnesses of siblings	0.3	0.4	1.1	-1.0	0.5	0.4	0.3
Neuroticism score	0.3	0.6	1.0	-0.8	-1.0	0.6	-0.6
Weight	7.6	37.1	65.8	-6.7	-0.7	8.1	-6.2
Impedance of arm (right)	1.8	8.6	17.6	3.8	1.0	-4.2	1.3
Arm fat percentage (right)	1.1	4.4	10.4	3.2	-1.3	-1.5	-1.8
Trunk fat-free mass	18.5	106.2	193.2	-13.9	0.1	13.6	-6.8
Hip circumference	3.8	16.4	30.0	-3.7	-0.2	5.5	-4.6
Time employed in main current job	0.6	0.7	1.2	1.1	0.5	-1.1	0.3
Alcohol intake versus 10 years previously	0.7	1.0	2.8	-0.9	-0.7	1.7	0.3
Father’s age at death	0.8	1.1	3.2	-0.5	1.8	0.4	0.7
Worrier / anxious feelings	0.4	0.7	1.3	-1.2	0.7	1.1	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.0	-0.1	-1.4	0.7	-0.4
Falls in the last year	0.0	0.0	0.0	-0.0	-0.0	0.1	0.1
Hair/balding pattern: Pattern 3	1.8	2.7	5.6	-1.6	2.4	1.4	-0.9
Number of live births	1.4	1.9	3.5	1.9	-1.0	-1.6	0.8
Forced expiratory volume in 1-second (FEV1)	2.2	7.3	16.7	-4.1	-1.0	3.2	-1.1
Pulse rate	2.4	4.1	7.0	2.6	-1.8	-2.4	0.5
Happiness	1.4	1.7	3.2	0.1	1.1	1.5	-1.8
Noisy workplace	2.9	3.6	8.1	1.2	-0.9	-2.0	2.8
Qualifications: A levels/AS levels or equivalent	1.9	4.2	6.6	-2.3	1.5	2.6	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	-0.3	0.9	-0.0	-0.1
Mouth/teeth dental problems: Dentures	0.2	0.3	0.6	-0.3	-0.7	-0.2	0.8
Asthma	1.3	2.6	6.3	-0.8	0.8	2.5	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.8	-0.3	0.9	0.2	0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	1.2	0.4	-0.9	-0.3
Depression (self-reported)	0.0	0.0	0.1	0.2	-0.2	-0.3	-0.1
Medication: Lansoprazole	2.6	2.9	5.1	0.6	-1.5	-2.2	2.0
Prospective memory result	3.4	4.2	6.6	-0.1	-2.3	-2.2	2.6
Lung cancer (father)	2.6	3.0	5.3	-0.6	-2.3	-1.5	2.1
Illnesses of mother	1.2	1.5	2.7	-1.5	-1.1	1.6	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.7	18.8	-4.3	-2.0	2.8	-0.2
Pulse wave Arterial Stiffness index	0.5	0.6	1.4	-0.3	0.7	0.5	-1.2
Impedance of arm (left)	1.4	6.4	12.7	3.3	1.0	-3.6	1.1
Arm fat mass (right)	1.4	5.7	14.1	-0.7	-1.3	2.6	-3.8
Trunk predicted mass	18.9	107.8	196.0	-14.0	0.1	13.7	-6.9
Standing height	18.6	184.2	365.7	-19.1	1.0	17.3	-8.3
Length of working week for main job	5.2	5.8	10.2	-2.1	1.9	3.2	-2.2
Exposure to tobacco smoke at home	0.3	0.4	0.9	1.0	-0.4	0.5	-0.4
Breastfed as a baby	0.9	1.2	2.0	-1.4	1.2	0.5	1.0
Tense / ‘highly strung’	0.1	0.1	0.2	0.1	0.0	0.5	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.2	1.8	4.4	-0.2	-0.2	1.6	-2.1
Hair/balding pattern: Pattern 4	0.5	1.1	2.9	0.4	1.7	-1.1	0.6
Birth weight of first child	0.6	1.1	2.1	0.9	-0.2	-1.4	1.2
Peak expiratory flow (PEF)	4.5	10.5	19.4	-3.9	0.3	4.4	-2.7
Pulse wave reflection index	0.6	0.7	1.6	-1.0	0.3	1.3	-0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.7	-0.5	-0.7	-0.4	-0.8
Loud music exposure frequency	0.6	0.6	1.3	0.2	-1.0	-1.1	0.2
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	3.5	-1.4	0.7	1.9	-1.6
Mouth/teeth dental problems: Bleeding gums	1.2	1.5	3.3	1.8	-1.1	-1.0	-0.7
Blood clot in the leg (DVT)	2.9	3.8	9.0	-3.0	-2.2	0.7	0.9
Medication: Paracetamol	0.1	0.2	0.3	0.4	-0.2	0.4	-0.5
Headache pain in last month	0.9	1.5	4.2	-2.0	-0.5	1.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.8	-0.1	0.5	0.3
Glaucoma (self-reported)	0.1	0.1	0.2	0.1	-0.2	0.4	0.1
Gout (self-reported)	0.0	0.1	0.2	0.1	-0.4	-0.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.1	0.8	-1.5	0.2	0.3
Medication: Amlodipine	0.3	0.5	0.9	0.3	1.0	0.3	-0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.6	-0.9	-0.4	2.1	-0.2
Birth weight	1.0	2.2	6.6	-2.6	-1.2	0.1	0.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.6	0.4	-0.9	-1.9	0.8
High blood pressure (siblings)	0.1	0.2	0.3	-0.2	-0.4	0.4	-0.6
Forced vital capacity (FVC), Best measure	2.1	7.9	19.7	-4.4	-1.8	2.9	-0.2
Body fat percentage	0.9	3.5	8.6	2.9	-0.7	-1.1	-2.0
Leg fat percentage (right)	1.9	7.0	20.2	4.5	-0.2	-2.6	-1.0
Arm fat-free mass (right)	16.2	82.9	148.8	-12.0	-0.5	12.2	-6.2
Exposure to tobacco smoke outside home	0.2	0.3	0.7	-0.0	0.3	0.8	-0.6
Comparative body size at age 10	1.1	3.1	6.4	2.5	-2.0	-1.1	-0.7
Number of full brothers	0.4	0.5	1.9	0.2	-1.4	-0.1	0.2
Worry too long after embarrassment	0.1	0.2	0.6	-0.8	-0.1	0.1	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.8	-0.6	-0.3	1.3	-1.7
Wheeze or whistling in the chest in last year	0.6	1.1	2.7	-1.2	-0.3	1.6	-0.4
Number of children fathered	0.4	0.5	1.4	-0.7	1.2	-0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.8	1.0	2.7	0.1	-0.4	-1.0	1.7
Age at first live birth	1.0	1.8	3.5	-1.9	1.6	0.1	0.9
Pulse wave peak to peak time	0.3	0.3	0.4	-0.7	-0.6	0.5	0.5
Health satisfaction	0.5	0.7	2.0	0.1	-0.8	0.4	-1.4
Shortness of breath walking on level ground	2.2	2.6	9.3	0.9	-3.0	-0.5	-0.3
Qualifications: College or University degree	3.5	11.0	18.4	-3.7	2.6	4.3	-2.3
Eye problems/disorders: None of the above	0.3	0.3	0.6	-0.4	0.8	0.1	-0.8
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.1	0.1	-0.2	-0.2	0.3
Emphysema/chronic bronchitis	1.8	2.0	2.9	-0.5	-1.4	-1.7	1.7
Medication for pain relief, constipation, heartburn	0.4	0.6	1.2	-1.0	0.6	-0.2	1.1
Neck or shoulder pain in last month	0.2	0.2	0.5	0.7	0.5	-0.1	0.3
Medication: Blood pressure	0.2	0.3	0.6	0.5	0.7	0.4	-0.6
Angina (self-reported)	0.4	0.5	1.8	-0.4	-1.4	0.4	-0.1
Migraine (self-reported)	1.3	1.7	4.4	-0.8	-0.8	2.1	-1.0
Medication: Ibuprofen	0.2	0.2	0.3	-0.3	0.6	0.5	-0.3
Medication: Allopurinol	0.1	0.1	0.3	0.6	-0.2	-0.0	-0.3
Medication: Omeprazole	0.7	0.8	2.2	0.6	1.5	0.8	-0.2
Medication: Seretide 50 evohaler	0.7	0.8	1.7	0.4	0.9	1.3	-0.8
Mean time to correctly identify matches	2.6	4.9	9.4	2.9	-1.0	-3.1	1.0
Heart disease (mother)	1.1	1.4	1.8	1.2	-1.1	-1.0	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.7	0.4	-0.8	-0.9	0.6
Whole body fat mass	1.7	6.9	14.9	-1.6	-0.7	3.1	-3.9
Leg fat mass (right)	0.9	3.4	10.1	0.1	-0.6	1.8	-3.2
Arm predicted mass (right)	16.2	82.8	149.1	-12.0	-0.2	12.2	-6.1
Pulse rate, automated reading	1.0	3.2	7.4	2.7	-1.5	-1.7	0.3
Alcohol intake frequency.	0.1	0.3	0.9	0.9	0.6	0.0	0.0
Comparative height size at age 10	12.0	65.8	114.5	-9.8	0.8	10.7	-7.2
Number of full sisters	1.8	2.1	4.6	2.1	-1.1	-1.5	-0.7
Suffer from ‘nerves’	0.3	0.5	1.3	-0.5	0.4	0.7	-1.1
Overall health rating	0.8	1.8	5.0	2.2	-1.1	-0.8	-0.6
Chest pain or discomfort	3.1	4.5	7.5	-0.8	1.5	2.7	-2.7
Had major operations	0.5	0.6	0.9	0.7	-1.0	-0.6	0.8
Age at last live birth	0.8	1.2	2.9	-1.7	1.0	0.9	-0.3
Family relationship satisfaction	0.3	0.4	1.1	-0.5	-0.1	1.1	0.2
Leg pain on walking	0.8	1.0	3.9	0.1	-2.0	0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	1.1	0.1	-1.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.6	0.2	0.1	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.4	-0.3	1.5	0.3	0.0
Medication: Aspirin	1.7	2.3	5.3	2.3	0.4	-0.5	-1.9
Supplements: Vitamin C	0.2	0.2	0.6	0.6	-0.8	-0.2	0.1
Knee pain experienced in last month	6.1	9.5	15.8	3.8	-2.0	-4.0	1.9
Hypertension (Self-reported)	0.2	0.5	1.6	1.3	-0.2	-0.5	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	0.4	0.3	-0.1	-0.3
Illnesses of father: Heart disease	1.7	2.3	5.4	2.3	1.3	0.6	-1.4
Illnesses of siblings: Diabetes	0.3	0.4	0.5	0.7	-0.7	0.0	-0.7
Smoking status: Previous	1.4	2.1	4.7	0.8	-0.4	-1.7	2.2
Forced expiratory volume in 1-second (FEV1), predicted	6.1	12.8	28.0	-5.3	-0.9	4.2	-2.2
Whole body fat-free mass	16.6	94.9	169.0	-12.9	-0.2	13.0	-6.7
Leg fat-free mass (right)	13.4	71.8	130.0	-10.9	-0.9	11.4	-6.2
Arm fat percentage (left)	1.1	4.2	10.0	3.2	-1.4	-1.3	-1.9
Average weekly red wine intake	1.7	2.6	5.5	-2.3	1.7	1.3	-0.0
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.5	-0.8	1.0	-0.8	1.6
Mood swings	0.4	0.8	2.4	-0.6	-1.5	0.6	-0.4
Loneliness, isolation	1.2	1.6	3.2	1.8	-1.5	-0.9	-0.3
Long-standing illness, disability or infirmity	0.5	0.7	1.4	-0.3	-1.1	-0.4	1.2
Ever had bowel cancer screening	0.2	0.3	0.7	0.9	-0.4	-0.2	0.4
Diabetes diagnosed by doctor	2.0	3.3	6.0	-1.2	0.0	2.5	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	0.8	0.2	-0.2	0.1
Friendships satisfaction	0.5	0.6	1.2	1.1	-0.9	-0.1	0.5
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.5	0.6	0.9	-0.3
Commuting to job workplace: Walk	2.5	2.7	7.6	-2.8	0.4	1.7	0.2
Eye problems/disorders: Cataract	0.3	0.3	1.0	-0.1	-0.5	1.0	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.3	1.1	0.2	-0.7	-0.7
Medication for cholesterol	0.2	0.3	0.6	-0.1	-0.6	-0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.0	0.1	0.1	0.8	-1.7
Back pain experienced in last month	1.1	1.5	3.0	0.2	-1.4	-1.7	1.1
Mineral and other dietary supplements	0.8	1.1	2.8	-0.6	-0.8	0.7	-1.7
Breast cancer (self-reported)	0.4	0.5	0.8	-0.9	-0.8	0.5	0.5
Asthma (self-reported)	1.2	2.4	6.0	-0.6	0.7	2.4	-1.7
Osteoporosis (self-reported)	2.6	3.2	6.2	1.7	-2.5	-1.7	1.0
Osteoarthritis (self-reported)	1.2	1.5	3.5	1.9	-1.0	-1.3	0.3
Medication: Aspirin	1.6	2.1	5.1	2.3	0.0	-0.5	-1.7
Medication: Gliclazide	0.8	0.9	1.8	-0.5	-1.0	0.9	-1.3
Illnesses of father: None of the above (group 1)	1.6	2.0	4.3	-1.7	0.5	-0.7	2.1
Smoking status: Current	1.2	1.9	4.9	0.8	-2.2	-1.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	0.3	-0.8	-1.3	1.2
Whole body water mass	16.5	94.2	166.4	-12.9	-0.4	12.9	-6.6
Leg predicted mass (right)	13.5	71.9	130.0	-10.9	-0.9	11.4	-6.2
Arm fat mass (left)	1.5	6.0	13.2	-1.2	-1.3	2.8	-3.6
Number of self-reported non-cancer illnesses	1.1	2.0	5.3	1.4	-2.3	-0.8	-0.1
Average weekly champagne plus white wine intake	0.8	1.0	2.5	-0.6	0.4	1.6	-1.1
Miserableness	0.5	0.9	2.2	0.7	-0.9	0.1	-1.5
Guilty feelings	1.4	2.1	5.8	-1.4	-2.4	-0.1	0.8
Wears glasses or contact lenses	1.2	1.4	3.0	-1.7	1.2	1.0	0.1
Ever taken oral contraceptive pill	0.8	0.9	2.1	0.2	0.6	-1.5	1.0
Hearing aid user	1.6	1.8	4.8	-0.5	-0.7	-1.3	2.2
Mother’s age at death	0.8	1.0	2.7	-0.2	1.6	-0.5	1.0
Financial situation satisfaction	0.8	1.0	3.3	-0.2	-1.8	-0.3	0.9
Tinnitus: Yes, now most or all of the time	2.4	2.8	5.3	-1.3	0.3	2.3	-2.1
Commuting to job workplace: Public transport	1.5	1.8	4.8	-1.2	0.6	2.2	-0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.6	0.8	0.2	-0.4	0.4
Medication: Blood pressure	0.8	1.5	2.4	-1.1	0.5	1.6	-1.5
Pain type(s) experienced in last month: Hip pain	2.0	2.5	5.4	2.3	-0.1	-0.5	-2.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.0	0.2	1.1	0.1	1.4
High cholesterol (Self-reported)	1.1	2.0	3.2	1.5	1.8	-1.3	-1.0
Medication: Bendroflumethiazide	0.3	0.5	0.8	-0.4	0.9	0.7	-0.7
Medication: Paracetamol	0.5	0.7	1.1	1.1	0.4	0.7	-1.0
Medication: Lisinopril	0.5	0.7	1.2	0.0	-1.1	0.7	-1.0
Medication: Atorvastatin	0.4	0.4	0.9	0.9	-0.1	-0.9	-0.3
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.1	-0.3	0.4	-0.2
Alcohol drinker status: Never	0.2	0.3	0.8	0.3	0.9	0.4	0.3
Ever smoked	1.0	1.8	3.3	0.2	-1.4	-1.4	1.8
Basal metabolic rate	14.4	79.6	141.6	-11.5	-0.5	11.9	-6.6
Leg fat percentage (left)	1.8	6.5	18.4	4.3	-0.4	-2.4	-1.2
Arm fat-free mass (left)	15.0	76.0	134.9	-11.5	-0.3	11.6	-6.1
Number of operations (self-reported)	0.8	1.2	1.5	1.2	-0.9	-1.2	1.1
Average weekly beer plus cider intake	1.9	2.8	5.6	2.1	-0.5	-2.4	1.0
Irritability	1.0	1.6	3.9	-2.0	1.3	0.8	0.4
Risk taking	0.6	0.8	2.4	-0.5	-1.6	0.7	-0.5
Ever had prostate specific antigen (PSA) test	1.2	1.4	3.3	-0.2	1.8	1.1	-1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.8	0.1	0.2	-0.2	-1.4
Age started oral contraceptive pill	1.3	1.6	4.6	-2.1	0.8	0.4	1.1
Diastolic blood pressure, automated reading	1.1	3.4	6.7	2.6	-1.8	-0.0	-2.0
Ever depressed for a whole week	0.8	1.0	1.6	1.0	-0.8	-1.3	0.9
Unable to work because of sickness or disability	4.3	5.6	9.4	1.4	-2.8	-3.1	1.7
Commuting to job workplace: Cycle	0.4	0.5	0.9	-0.5	-0.4	0.9	-0.8
Myopia	4.8	7.0	11.3	-2.7	2.6	3.4	-1.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.3	-1.1	0.8	0.0	0.8
Cholesterol lowering medication	0.7	1.0	2.1	0.2	1.3	-0.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.0	0.9	1.0	0.6	-0.8
Pain experienced in last month	0.9	1.5	2.7	-1.6	0.8	1.5	-0.6
Supplements: Calcium	0.8	0.9	2.3	0.2	-1.5	-1.1	0.5
Basal cell carcinoma (self-reported)	2.3	2.8	5.2	2.1	2.3	-0.5	-1.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	0.4	0.1	-0.2	0.3
Deep venous thrombosis (DVT) (self-reported)	3.1	4.0	9.8	-3.1	-2.2	0.8	0.9
Heart disease (siblings)	1.1	1.3	3.7	0.8	-1.9	-0.9	-0.3
Alcohol drinker status: Previous	0.4	0.5	0.9	-0.2	-0.6	-0.8	1.0
Pack years of smoking	0.6	1.0	2.8	-0.0	-0.7	0.8	-1.7
Impedance of whole body	2.3	11.7	22.5	4.3	1.3	-4.7	1.9
Leg fat mass (left)	1.0	3.9	10.9	-0.2	-0.6	2.0	-3.3
Arm predicted mass (left)	15.1	76.9	136.9	-11.3	-0.3	11.7	-6.5