Hub : Genes

RBMS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0935 0.0201 0.00000 0.105 0.108 0.123 0.119 0.124 1.6e-32 2.6e-33 5.7e-38 7.1e-37 1.9e-38
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0664 0.0335 0.00043 0.014 0.038 0.059 NA 0.041 9.1e-03 4.1e-05 3.2e-07 NA 1.8e-05
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.0490 0.0320 0.00950 -0.004 0.008 -0.001 NA -0.003 6.8e-01 1.0e-01 3.7e-01 NA 5.0e-01
4 TCGA Brain Lower Grade Glioma 0.0306 0.0197 0.00650 0.009 0.017 0.009 NA 0.013 2.6e-02 4.6e-03 3.0e-02 NA 1.2e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.1 0.2 0.8 -0.1 -0.9 0.2 0.3
Bipolar Disorder or Schizophrenia 0.2 0.5 0.9 0.9 -0.3 1.0 -0.5
Depressed Affect (Nagel 2018) 0.7 1.4 3.9 -2.0 -0.9 -0.9 0.3
Depression (Nagel 2018) 0.3 0.5 0.8 -0.9 -0.9 -0.5 -0.1
Intelligence (Savage-Jansen 2018) 2.5 7.8 12.4 -2.5 -1.4 -3.2 3.5
Neuroticism (Nagel 2018) 1.3 3.2 5.3 -2.3 -1.8 -1.3 1.5
Schizophrenia (2018) 0.4 0.8 1.4 1.2 0.3 1.1 -0.8
Schizophrenia vs Biploar Disorder 2.0 2.6 4.1 1.1 1.5 1.7 -2.0
Worry (Nagel 2018) 1.9 3.9 7.1 -2.7 -1.8 -1.7 1.6
Alzheimer’s Disease (in mother) 2.2 2.6 3.6 -1.9 -1.3 -1.9 1.3
Alzheimer’s Disease (in father) 2.3 2.5 6.1 -1.4 -0.3 -2.5 1.4
Alzheimer’s Disease (including proxy) 1.8 2.7 5.3 -2.1 -0.4 -2.3 0.9
Crohns Disease (2017) 5.4 11.9 15.7 -3.1 -2.6 -3.9 4.0
Irritable Bowel Disease (IBD) 6.0 14.4 22.4 -3.1 -2.8 -4.2 4.7
Ulcerative Colitis (UC) 3.2 6.0 11.4 -1.7 -1.7 -2.6 3.4
Major Depression (MDD) 0.9 1.1 2.1 -0.3 -1.3 -0.8 1.4
Reaction Time 1.1 2.1 4.4 -0.9 -1.5 -0.8 2.1
Verbal and Numeric Reasoning (VNR) 2.3 5.6 11.5 -1.5 -1.1 -2.7 3.4
Breast Cancer 0.4 1.0 2.9 0.9 -0.3 -0.1 1.7
Ovarian Cancer 0.4 0.5 1.0 0.4 -0.9 0.5 1.0
Prostate Cancer 0.3 0.4 0.9 0.9 0.3 0.8 -0.5
Age at First Birth 0.5 0.8 2.6 -0.1 -0.7 -0.2 1.6
Bipolar Disorder (2011) 0.1 0.1 0.2 0.4 -0.1 -0.1 -0.2
Body Mass Index (BMI) (2010) 0.4 0.6 1.2 0.8 -0.2 1.1 -0.7
Coronary Artery Disease (CAD) 0.2 0.2 0.4 -0.4 -0.4 0.5 0.6
Crohns Disease (2012) 4.6 7.5 9.9 -2.8 -1.9 -3.0 3.1
Mean Putamen Volume 0.6 0.7 2.1 0.7 -1.5 0.4 0.3
Fasting Glucose 0.3 0.3 0.6 0.2 -0.4 0.7 -0.8
HbA1C 0.0 0.0 0.1 -0.1 -0.0 0.3 0.3
HDL Cholesterol 0.4 0.6 1.8 0.1 -0.3 -0.7 1.4
LDL Cholesterol 0.1 0.2 0.2 0.5 0.1 0.5 -0.4
Lupus 4.1 6.1 8.3 2.1 2.2 2.6 -2.9
Neuroticism (2016) 0.3 0.5 1.3 -1.1 -0.5 -0.4 0.3
Primary Biliary Cirrhosis 1.0 1.5 2.7 1.6 1.1 1.4 -0.2
Rheumatoid Arthritis 0.1 0.1 0.4 -0.0 0.3 -0.6 0.2
Schizophrenia (2014) 0.1 0.2 0.5 0.7 0.2 0.7 -0.1
Triglycerides 0.2 0.3 0.7 0.8 -0.4 0.7 0.2
Type 2 Diabetes (T2D) (2012) 11.7 13.5 19.8 3.7 2.9 4.5 -3.5
Ulcerative Colitis 2.8 4.0 8.1 -0.9 -1.2 -2.4 2.8
Blood Eosinophil Count 0.4 2.9 9.0 -0.0 -3.0 1.4 0.7
Blood Platelet Count 1.2 14.3 19.8 -4.5 -3.6 -3.8 3.1
Blood Red Count 0.5 5.3 11.9 -0.4 -3.4 0.3 3.0
Blood White Count 1.2 8.5 15.2 2.2 -3.9 3.4 1.6
Heel T-Score 0.1 1.1 2.6 -1.6 -0.4 -1.3 -0.1
BMI 2.3 13.6 21.3 3.9 1.0 4.6 -4.2
Height 0.2 3.0 9.2 0.5 -1.4 0.7 3.0
Waist Hip Ratio (WHR) 0.4 1.7 2.0 1.4 -1.3 1.4 1.0
Systolic Blood Pressure 0.2 1.2 2.6 -0.8 -1.6 -0.1 1.2
Smoking Status 0.2 0.6 1.0 0.8 -1.0 0.7 -0.2
Allergy or Eczema 1.1 3.0 4.9 -1.1 -2.2 -1.3 2.1
Cardiovascular Disease 0.3 1.0 2.9 1.0 -0.4 1.7 -0.1
Hypothyroidism (self reported) 0.2 0.4 1.5 0.3 -1.2 -0.0 0.3
Respiratory disease 0.0 0.0 0.0 0.1 -0.1 0.1 -0.2
Type 2 Diabetes (T2D) (2018) 1.1 2.1 3.0 1.4 0.8 1.6 -1.7
Lung FEV1/FVC ratio 1.9 9.7 18.0 1.1 4.1 1.7 -4.2
Lung FVC 1.3 6.6 12.2 1.8 3.2 0.9 -3.5
Neuroticism 1.7 4.0 7.7 -2.8 -1.8 -1.6 1.6
Chronotype (morning person) 0.5 1.2 2.8 1.0 -0.9 0.5 1.7
Hair Pigment 0.1 1.5 2.8 1.7 -0.9 1.4 -0.7
Tanning 0.3 3.8 5.1 1.3 2.2 1.9 -2.2
Hand grip strength (left) 0.7 1.8 3.5 1.6 0.3 1.1 -1.9
Number of treatments/medications taken 0.3 0.5 1.2 -0.5 -1.1 -0.1 0.6
Average weekly spirits intake 0.7 0.8 1.8 1.4 -0.9 0.8 0.4
Sensitivity / hurt feelings 2.3 3.9 4.4 -1.9 -2.0 -2.0 2.1
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.7 -1.2 -1.3 -1.3 0.1
Hearing difficulty/problems: Yes 1.1 1.6 3.2 1.4 -0.9 0.8 1.8
Relative age of first facial hair 2.0 4.0 7.9 -1.2 -1.6 -2.1 2.8
Other serious medical condition/disability diagnosed by doctor 0.3 0.5 1.1 1.1 0.3 0.6 -0.5
Ever used hormone-replacement therapy (HRT) 1.0 1.2 2.0 1.0 -1.4 0.8 1.2
Ever had hysterectomy (womb removed) 0.4 0.5 1.4 0.2 -0.6 -0.2 1.2
Systolic blood pressure, automated reading 0.4 1.2 2.0 0.8 -1.3 1.4 0.4
Eye problems/disorders: Diabetes related eye disease 4.8 5.3 7.8 2.5 0.6 2.8 -2.6
Angina 4.1 5.4 8.5 2.3 1.2 2.5 -2.9
Medication for hormone replacement therapy 1.3 1.5 3.9 -0.5 -2.0 -0.8 1.1
Vitamin and mineral supplements 0.6 0.8 1.5 0.6 -0.6 1.2 -1.0
Supplements: Zinc 0.4 0.5 1.6 0.1 -1.3 0.3 0.4
Medication: Co-codamol 2.1 2.5 7.5 -2.7 -0.1 -1.4 0.5
Medication: Metformin 3.3 4.6 8.1 2.3 0.8 2.8 -2.2
Diabetes (father) 0.9 1.1 2.6 0.4 -1.2 -0.3 1.6
Diabetes (mother) 1.3 1.6 3.3 1.7 0.6 1.8 -0.3
Severe depression (siblings) 11.4 12.8 14.5 -3.2 -3.8 -3.6 3.7
Pack years adult smoking proportion 0.4 0.5 1.8 0.3 -0.1 0.5 -1.3
Impedance of leg (right) 3.7 17.9 33.3 -3.3 -2.9 -4.4 5.8
Leg fat-free mass (left) 2.2 11.7 17.4 3.3 2.0 4.2 -3.8
Trunk fat percentage 1.1 4.3 8.5 2.9 -0.4 2.9 -0.7
Hand grip strength (right) 1.0 2.7 4.9 2.2 0.7 1.6 -1.7
Townsend deprivation index at recruitment 2.3 3.3 4.1 1.7 1.8 2.0 -1.7
Current tobacco smoking 0.1 0.2 0.4 0.3 -0.6 0.4 -0.5
Average weekly fortified wine intake 1.5 1.8 4.2 -0.3 -1.2 -1.1 2.0
Maternal smoking around birth 0.2 0.3 0.8 0.2 0.2 0.4 -0.9
Fed-up feelings 0.5 0.9 2.2 -1.5 -0.2 0.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 0.6 -0.8 0.6 -0.3 -0.7
Relative age voice broke 6.1 9.2 15.5 -2.0 -2.2 -3.6 3.9
Taking other prescription medications 0.1 0.2 0.5 0.1 -0.4 0.7 -0.3
Age when periods started (menarche) 1.0 2.4 3.6 -0.9 -1.5 -1.9 1.7
Bilateral oophorectomy (both ovaries removed) 0.9 1.1 1.9 0.6 -0.6 1.4 -1.3
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.2 -1.1 0.2 -0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 0.7 0.8 1.2 -0.8 -0.5 -1.1 0.9
Qualifications: CSEs or equivalent 1.0 1.3 1.9 0.9 0.8 1.3 -1.4
Serious illness, injury or assault to yourself 0.9 1.0 1.9 -0.3 -1.3 -0.7 1.4
High blood pressure 0.2 0.6 1.0 0.4 -0.8 0.7 1.0
Hayfever, allergic rhinitis or eczema 1.4 3.1 5.1 -1.3 -1.7 -1.7 2.2
Multivitamins +/- minerals 0.6 0.7 2.5 0.4 1.6 -0.2 -0.4
Stomach or abdominal pain in last month 0.5 0.6 1.1 -1.1 -0.9 -0.6 -0.1
Supplements: Glucosamine 0.1 0.1 0.3 0.5 -0.4 0.1 0.2
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 0.5 -0.2 0.5 -0.7
Medication: Atenolol 1.3 1.7 2.4 1.2 1.1 1.3 -1.6
Medication: Levothyroxine sodium 0.0 0.0 0.1 -0.2 -0.3 -0.1 0.1
Sitting height 0.1 0.5 1.3 0.4 1.1 0.7 -0.2
Chronic bronchitis/emphysema (father) 0.2 0.2 0.5 0.2 -0.7 0.2 0.4
High blood pressure (mother) 1.2 1.7 2.8 1.7 1.0 1.4 -1.0
Body mass index (BMI) 4.0 17.2 24.5 4.3 2.1 5.0 -4.6
Impedance of leg (left) 3.3 16.0 31.5 -2.9 -2.6 -4.2 5.6
Leg predicted mass (left) 2.3 12.0 18.0 3.3 2.0 4.2 -3.8
Trunk fat mass 1.6 6.8 12.7 3.4 0.3 3.6 -1.6
Waist circumference 2.4 8.9 17.2 3.8 0.2 4.2 -2.0
Number of incorrect matches in round 0.2 0.4 0.9 0.9 -0.1 0.4 0.7
Past tobacco smoking 0.7 1.4 2.7 0.3 1.6 0.2 -1.6
Alcohol usually taken with meals 2.7 4.4 8.4 -0.8 -2.5 -1.5 2.9
Nervous feelings 0.4 0.8 2.1 -1.4 -0.7 -0.7 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.2 0.3 0.6 -0.6 -0.8 -0.2 0.0
Hearing difficulty/problems with background noise 0.7 1.2 2.1 -0.9 -1.4 -0.4 1.3
Hair/balding pattern: Pattern 2 1.8 2.3 3.4 1.1 1.5 1.8 -1.5
Had menopause 0.2 0.3 0.7 0.1 -0.6 0.1 0.9
Had other major operations 1.5 1.8 2.2 -1.5 -1.4 -0.9 1.5
Forced vital capacity (FVC) 1.0 3.8 7.0 1.7 2.6 1.0 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.2 -1.1 -0.1 -0.8 0.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 2.7 -0.5 -1.0 -1.2 1.6
Qualifications: None of the above 3.9 8.4 15.1 2.5 1.5 3.2 -3.9
Financial difficulties in last 2 years 0.2 0.2 0.4 0.6 -0.2 0.5 -0.6
Mouth/teeth dental problems 2.9 4.5 6.0 -1.9 -2.4 -2.1 2.0
Heart attack 1.1 1.4 2.4 0.5 1.5 0.9 -1.5
Allergy 0.9 2.0 3.6 0.8 1.4 1.2 -1.9
Pain all over the body in last month 1.2 1.3 1.9 -0.6 -1.4 -1.0 1.4
Diabetes (self-reported) 2.3 3.6 4.8 2.0 0.9 2.2 -2.2
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.7 -0.2 1.7 0.1 -0.3
Medication: Ramipril 0.4 0.5 1.1 0.8 1.1 0.3 0.0
Medication: Simvastatin 1.4 2.1 3.6 1.1 1.2 1.4 -1.9
Fluid intelligence score 1.3 2.7 7.0 -0.7 -0.2 -1.7 2.6
Illnesses of siblings 0.9 1.2 2.2 -1.5 -1.0 -1.0 0.7
Neuroticism score 3.7 7.8 11.0 -3.3 -2.6 -2.8 2.3
Weight 2.5 12.5 21.1 4.0 1.5 4.6 -3.3
Impedance of arm (right) 2.8 12.9 27.2 -1.9 -3.2 -3.2 5.2
Arm fat percentage (right) 2.2 8.5 14.5 3.6 0.5 3.8 -2.5
Trunk fat-free mass 1.6 8.9 12.8 2.7 2.2 3.6 -3.3
Hip circumference 1.1 4.8 9.4 2.8 -0.1 3.1 -1.3
Time employed in main current job 1.6 1.8 4.8 -0.5 2.2 0.1 -1.5
Alcohol intake versus 10 years previously 0.2 0.3 1.1 -0.3 0.3 0.1 -1.1
Father’s age at death 0.6 0.8 2.2 1.5 -0.3 1.0 0.2
Worrier / anxious feelings 3.6 6.8 9.4 -3.1 -1.8 -2.8 2.6
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 -1.2 -1.0 -0.3 0.5
Falls in the last year 1.0 1.4 2.5 -0.2 -1.3 -1.1 1.6
Hair/balding pattern: Pattern 3 0.6 0.9 1.4 -0.1 -1.1 -1.2 1.0
Number of live births 0.5 0.7 1.3 1.1 -0.0 1.1 -0.6
Forced expiratory volume in 1-second (FEV1) 1.7 5.8 11.8 1.6 3.4 0.9 -2.9
Pulse rate 3.7 6.3 9.4 -1.5 -3.1 -2.8 2.4
Happiness 1.7 2.1 4.2 -1.6 -0.5 -2.0 1.2
Noisy workplace 0.8 0.9 2.4 -1.0 -1.6 -0.5 0.3
Qualifications: A levels/AS levels or equivalent 3.6 8.1 11.6 -3.0 -1.5 -3.4 3.1
Serious illness, injury or assault of a close relative in last 2 years 2.8 3.2 5.8 -1.8 -0.6 -2.4 1.8
Mouth/teeth dental problems: Dentures 3.3 5.6 6.6 2.5 2.0 2.6 -2.3
Asthma 0.1 0.2 0.5 0.0 -0.7 0.5 -0.1
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.2 -0.1 0.4 -0.4 0.2
Medication: Cholesterol lowering 0.4 0.7 1.0 0.5 0.8 1.0 -0.9
Depression (self-reported) 1.5 1.9 3.1 -1.8 -1.7 -1.0 0.7
Medication: Lansoprazole 3.1 3.5 7.0 1.3 0.6 2.2 -2.6
Prospective memory result 3.3 4.1 4.6 1.8 2.1 2.1 -2.0
Lung cancer (father) 0.3 0.4 1.3 -0.0 0.1 0.4 -1.2
Illnesses of mother 0.6 0.7 1.3 -1.0 0.7 -0.2 -1.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.8 5.7 14.8 0.9 3.9 0.4 -2.6
Pulse wave Arterial Stiffness index 0.5 0.6 1.6 -1.3 0.1 -0.7 -0.0
Impedance of arm (left) 2.7 12.6 28.2 -1.8 -2.9 -3.3 5.3
Arm fat mass (right) 3.0 12.4 20.4 4.1 1.3 4.5 -3.3
Trunk predicted mass 1.6 9.2 13.5 2.8 2.2 3.7 -3.3
Standing height 0.2 1.7 5.6 0.1 -1.1 -0.0 2.4
Length of working week for main job 1.1 1.3 2.7 1.1 0.0 1.6 -1.1
Exposure to tobacco smoke at home 1.1 1.2 2.1 1.0 0.4 1.4 -1.2
Breastfed as a baby 2.5 3.1 5.3 2.3 1.3 2.1 -0.9
Tense / ‘highly strung’ 0.3 0.4 1.2 -1.1 -0.4 -0.6 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 1.4 2.2 5.6 -0.5 -2.4 -0.4 1.7
Hair/balding pattern: Pattern 4 0.0 0.1 0.2 -0.2 0.5 -0.1 0.1
Birth weight of first child 1.6 2.9 6.2 -2.5 -1.0 -1.9 1.0
Peak expiratory flow (PEF) 0.5 1.3 2.2 -0.5 1.4 -1.5 -0.8
Pulse wave reflection index 1.4 1.8 4.5 -0.1 2.1 0.5 -1.5
Ever highly irritable/argumentative for 2 days 0.9 1.1 1.7 1.3 0.5 0.9 -1.3
Loud music exposure frequency 0.1 0.1 0.2 -0.3 0.2 -0.2 -0.4
Qualifications: O levels/GCSEs or equivalent 4.4 7.0 11.6 -3.3 -0.6 -3.4 2.3
Mouth/teeth dental problems: Bleeding gums 1.2 1.5 3.3 0.9 1.8 1.1 -0.9
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.5 0.6 -0.3 -0.4
Medication: Paracetamol 1.5 2.5 3.2 -1.8 -1.4 -1.6 1.4
Headache pain in last month 1.4 2.4 4.5 -2.1 -1.0 -1.8 0.9
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.4 0.1 -0.3 -0.2
Glaucoma (self-reported) 0.6 0.7 1.5 -0.3 -1.1 -0.1 1.2
Gout (self-reported) 0.0 0.0 0.0 -0.0 0.0 0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.4 0.0 -0.6 -0.0 0.0
Medication: Amlodipine 1.7 2.3 3.1 -1.4 -1.3 -1.6 1.8
Medication: Ventolin 100micrograms inhaler 0.2 0.2 0.3 0.6 -0.5 0.5 0.2
Birth weight 0.9 2.1 3.2 -1.8 1.8 -1.0 -1.0
Chronic bronchitis/emphysema (mother) 3.4 3.9 9.7 -0.4 -3.1 -0.7 2.3
High blood pressure (siblings) 1.0 1.5 3.4 1.9 0.9 1.1 -0.5
Forced vital capacity (FVC), Best measure 0.9 3.4 9.9 1.1 3.1 0.4 -1.6
Body fat percentage 1.1 4.5 8.4 2.9 -0.2 2.9 -1.1
Leg fat percentage (right) 1.5 5.4 9.5 2.9 0.6 3.1 -1.9
Arm fat-free mass (right) 1.8 9.0 12.6 2.7 2.2 3.5 -3.3
Exposure to tobacco smoke outside home 0.2 0.2 0.3 0.6 0.1 0.5 -0.4
Comparative body size at age 10 0.8 2.3 4.5 -1.0 2.1 -1.1 -1.5
Number of full brothers 4.1 5.1 6.4 1.8 2.2 2.5 -2.4
Worry too long after embarrassment 1.4 2.4 3.4 -1.6 -1.9 -1.1 1.5
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 5.5 -0.5 -2.4 -0.8 2.1
Wheeze or whistling in the chest in last year 1.3 2.4 6.2 -0.8 -2.5 -0.5 1.5
Number of children fathered 0.6 0.7 1.5 1.0 -0.1 1.2 -0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 -0.4 -1.4 -0.3 0.8
Age at first live birth 4.1 7.3 10.2 -3.0 -1.0 -3.2 3.0
Pulse wave peak to peak time 0.4 0.5 1.5 1.2 -0.1 0.7 0.3
Health satisfaction 3.8 4.9 8.5 -2.7 -0.8 -2.9 1.8
Shortness of breath walking on level ground 0.9 1.0 2.3 -1.5 0.1 -1.1 -0.7
Qualifications: College or University degree 4.1 12.9 27.6 -2.2 -3.2 -3.1 5.3
Eye problems/disorders: None of the above 2.5 2.9 5.9 1.3 1.5 1.4 -2.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.7 1.3 -0.1 0.9 -0.2
Emphysema/chronic bronchitis 0.7 0.8 2.2 1.5 0.3 0.8 0.2
Medication for pain relief, constipation, heartburn 0.5 0.8 1.9 1.4 0.4 0.8 -0.7
Neck or shoulder pain in last month 2.5 3.6 6.5 -2.5 -1.2 -2.1 1.5
Medication: Blood pressure 0.0 0.0 0.0 -0.1 -0.2 -0.1 0.2
Angina (self-reported) 3.9 5.1 7.9 2.2 1.1 2.5 -2.8
Migraine (self-reported) 0.6 0.7 1.3 -0.6 1.0 0.4 -1.1
Medication: Ibuprofen 0.0 0.0 0.0 -0.1 0.0 0.1 0.1
Medication: Allopurinol 0.5 0.6 0.8 0.9 0.6 0.9 -0.8
Medication: Omeprazole 0.7 0.8 1.4 -0.8 -1.2 0.0 1.1
Medication: Seretide 50 evohaler 0.5 0.5 0.8 -0.9 -0.5 -0.6 0.8
Mean time to correctly identify matches 1.9 3.6 9.2 -0.3 -2.1 -0.8 3.0
Heart disease (mother) 0.7 0.9 2.1 1.4 0.8 0.9 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 0.9 -0.5 -0.7 -0.9 0.9
Whole body fat mass 2.0 8.2 14.6 3.6 0.6 3.8 -2.2
Leg fat mass (right) 2.4 9.2 15.6 3.5 1.0 4.0 -2.8
Arm predicted mass (right) 1.7 8.9 13.2 2.8 2.1 3.6 -3.1
Pulse rate, automated reading 2.4 7.8 9.9 -2.1 -3.1 -3.0 2.8
Alcohol intake frequency. 4.1 9.5 19.5 1.4 2.9 2.9 -4.4
Comparative height size at age 10 0.4 2.2 5.6 -0.1 -1.8 0.2 2.4
Number of full sisters 8.6 10.5 15.9 4.0 2.3 3.6 -2.8
Suffer from ‘nerves’ 1.5 2.3 5.6 -2.4 -0.9 -1.5 0.8
Overall health rating 0.1 0.1 0.3 -0.3 -0.6 -0.2 0.2
Chest pain or discomfort 0.4 0.6 2.1 -0.7 -1.4 0.0 -0.1
Had major operations 0.3 0.4 1.2 -1.1 0.2 -0.5 -0.1
Age at last live birth 4.3 6.3 8.3 -2.9 -1.8 -2.8 2.3
Family relationship satisfaction 0.5 0.6 1.7 -0.2 -0.0 -0.8 1.3
Leg pain on walking 0.1 0.1 0.4 -0.3 -0.1 -0.6 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 1.7 1.1 1.1 1.1 -1.3
Commuting to job workplace: Car/motor vehicle 2.0 2.3 4.2 2.1 0.4 1.9 -1.1
Illness, injury, bereavement, stress in last 2 years 1.5 1.9 3.2 0.6 1.8 0.9 -1.8
Medication: Aspirin 2.1 2.7 5.2 0.8 1.5 1.7 -2.3
Supplements: Vitamin C 0.3 0.4 0.6 -0.5 -0.3 -0.6 0.8
Knee pain experienced in last month 0.3 0.5 0.9 -0.0 -0.9 0.3 1.0
Hypertension (Self-reported) 0.2 0.5 0.9 0.5 -0.6 0.8 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 4.8 -1.8 -2.2 -1.3 1.0
Illnesses of father: Heart disease 1.4 1.9 3.0 1.7 1.1 1.6 -1.0
Illnesses of siblings: Diabetes 0.3 0.4 0.9 -0.2 -0.7 -0.2 0.9
Smoking status: Previous 0.2 0.3 0.4 0.2 -0.7 0.6 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.9 -0.3 0.0 -0.3 0.9
Whole body fat-free mass 2.0 11.3 16.5 3.2 2.2 4.1 -3.7
Leg fat-free mass (right) 2.5 13.4 19.1 3.5 2.3 4.4 -4.1
Arm fat percentage (left) 2.3 9.0 15.0 3.8 0.8 3.9 -2.5
Average weekly red wine intake 1.4 2.0 4.8 1.2 -1.4 -0.1 2.2
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 0.6 0.7 0.9 -0.3
Mood swings 0.8 1.4 2.2 -1.3 -1.5 -0.9 0.9
Loneliness, isolation 0.1 0.1 0.3 -0.0 0.1 0.5 -0.2
Long-standing illness, disability or infirmity 0.5 0.7 1.5 0.9 -1.2 0.6 0.5
Ever had bowel cancer screening 0.0 0.0 0.1 -0.1 0.1 -0.4 0.1
Diabetes diagnosed by doctor 2.4 4.0 5.7 2.2 1.1 2.4 -2.0
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 2.3 0.3 0.9 0.8 -1.5
Friendships satisfaction 1.0 1.3 3.7 -0.4 -0.7 -0.8 1.9
Qualifications: nursing, teaching 3.6 5.6 11.3 -1.4 -1.6 -2.5 3.4
Commuting to job workplace: Walk 6.3 6.8 8.0 -2.6 -2.3 -2.6 2.8
Eye problems/disorders: Cataract 3.2 3.7 4.9 -1.8 -2.0 -1.6 2.2
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.9 -1.4 -0.1 -0.7 0.0
Medication for cholesterol 0.4 0.6 1.9 -0.2 1.4 -0.4 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.7 4.4 6.5 -2.0 -1.7 -2.5 2.0
Back pain experienced in last month 0.1 0.2 0.5 -0.7 0.5 -0.2 0.1
Mineral and other dietary supplements 0.7 0.9 2.4 0.2 0.5 0.9 -1.6
Breast cancer (self-reported) 1.3 1.5 3.9 -2.0 -0.8 -1.3 0.1
Asthma (self-reported) 0.0 0.1 0.2 -0.1 -0.4 0.4 -0.0
Osteoporosis (self-reported) 1.7 2.1 3.4 1.9 1.6 1.0 -1.3
Osteoarthritis (self-reported) 1.7 2.2 4.2 -0.9 -1.6 -1.2 2.1
Medication: Aspirin 1.4 1.9 3.5 0.5 1.3 1.4 -1.9
Medication: Gliclazide 2.3 2.6 6.0 1.1 0.8 1.6 -2.4
Illnesses of father: None of the above (group 1) 1.0 1.3 3.6 -1.9 0.1 -1.2 -0.3
Smoking status: Current 0.2 0.4 1.3 -0.2 -1.2 -0.2 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.9 6.1 14.9 0.7 3.9 0.6 -3.0
Whole body water mass 1.9 10.9 16.1 3.1 2.1 4.0 -3.7
Leg predicted mass (right) 2.5 13.1 18.7 3.5 2.2 4.3 -4.0
Arm fat mass (left) 3.2 13.2 21.7 4.2 1.4 4.7 -3.3
Number of self-reported non-cancer illnesses 0.2 0.4 0.7 0.6 -0.3 0.8 0.6
Average weekly champagne plus white wine intake 0.3 0.4 1.0 0.1 -0.0 -0.9 1.0
Miserableness 2.9 5.1 8.2 -2.9 -2.2 -2.3 1.4
Guilty feelings 0.1 0.2 0.3 0.0 -0.6 0.3 0.5
Wears glasses or contact lenses 0.2 0.2 0.4 0.0 0.7 0.4 -0.5
Ever taken oral contraceptive pill 0.6 0.7 1.4 -0.2 -1.2 -0.6 0.9
Hearing aid user 0.4 0.4 0.9 1.0 -0.7 0.5 -0.3
Mother’s age at death 0.4 0.5 1.6 0.7 0.1 0.1 1.3
Financial situation satisfaction 1.9 2.4 3.9 -1.4 2.0 -0.5 -1.8
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.7 -1.3 -1.1 -0.5 0.1
Commuting to job workplace: Public transport 4.3 5.2 7.3 -2.4 -0.7 -2.7 2.7
Eye problems/disorders: Glaucoma 2.1 2.5 3.9 -1.2 -1.8 -1.2 2.0
Medication: Blood pressure 0.1 0.2 0.6 -0.2 -0.1 -0.0 0.8
Pain type(s) experienced in last month: Hip pain 0.1 0.1 0.3 0.2 -0.2 0.6 -0.1
Supplements: Fish oil (including cod liver oil) 1.5 2.0 5.2 -0.4 -0.4 -1.6 2.3
High cholesterol (Self-reported) 0.1 0.3 0.6 0.5 0.0 0.8 -0.4
Medication: Bendroflumethiazide 0.1 0.2 0.4 0.5 0.6 0.5 -0.1
Medication: Paracetamol 3.5 5.4 8.2 -2.9 -1.6 -2.6 2.0
Medication: Lisinopril 0.1 0.2 0.3 -0.5 0.3 0.1 -0.6
Medication: Atorvastatin 0.1 0.1 0.2 -0.4 -0.4 0.3 -0.1
Illnesses of father: High blood pressure 0.6 0.8 1.3 0.9 -1.0 0.1 1.1
Alcohol drinker status: Never 0.8 1.0 1.9 0.8 0.2 1.2 -1.4
Ever smoked 2.8 4.8 9.9 -0.7 -2.7 -1.3 3.1
Basal metabolic rate 2.3 12.6 18.7 3.5 2.2 4.3 -3.8
Leg fat percentage (left) 2.0 7.2 11.4 3.3 1.0 3.4 -2.3
Arm fat-free mass (left) 1.8 9.1 14.3 2.8 1.8 3.8 -3.3
Number of operations (self-reported) 0.1 0.1 0.2 -0.2 -0.5 0.4 0.3
Average weekly beer plus cider intake 1.3 1.9 3.6 1.0 0.9 1.4 -1.9
Irritability 1.3 2.2 3.3 -1.4 -0.6 -1.8 1.8
Risk taking 0.6 0.9 1.9 1.4 0.4 1.2 -0.6
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.0 1.0 -0.1 1.0 -0.8
Fractured/broken bones in last 5 years 0.6 0.8 2.4 0.3 -0.5 -0.8 1.6
Age started oral contraceptive pill 0.5 0.7 2.3 -0.4 0.3 -0.3 1.5
Diastolic blood pressure, automated reading 0.2 0.6 1.5 0.3 -1.2 0.6 0.8
Ever depressed for a whole week 0.2 0.2 0.7 0.8 -0.2 0.3 0.1
Unable to work because of sickness or disability 0.1 0.2 0.4 -0.1 -0.4 0.6 -0.3
Commuting to job workplace: Cycle 1.2 1.5 4.3 -0.5 -0.4 -1.1 2.1
Myopia 0.3 0.5 0.7 -0.8 0.4 -0.8 0.6
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.8 -1.0 0.3 -1.3 -0.4
Cholesterol lowering medication 1.4 2.0 3.8 1.6 0.1 2.0 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.7 -0.8 -0.7 -0.2 0.8
Pain experienced in last month 1.2 2.0 3.2 1.8 0.8 1.5 -1.3
Supplements: Calcium 0.1 0.1 0.4 -0.1 -0.4 -0.3 0.6
Basal cell carcinoma (self-reported) 0.5 0.6 1.0 0.9 0.7 1.0 -0.3
Heart attack/myocardial infarction (self-reported) 1.4 1.8 3.2 0.7 1.5 1.1 -1.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.5 -0.7 0.6 -0.6 -0.2
Heart disease (siblings) 1.2 1.5 2.2 1.1 1.2 1.1 -1.5
Alcohol drinker status: Previous 0.3 0.3 0.6 0.8 0.5 0.6 -0.2
Pack years of smoking 0.3 0.5 1.6 0.3 -0.2 0.5 -1.3
Impedance of whole body 4.0 20.5 39.8 -3.0 -3.6 -4.5 6.3
Leg fat mass (left) 2.6 10.3 16.8 3.8 1.2 4.1 -3.0
Arm predicted mass (left) 1.9 9.8 15.0 2.8 1.9 3.9 -3.5