Hub : Genes

RCC2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Ovary	0.1830	0.0760	6.9e-03	-0.010	NA	0.003	NA	-0.012	6.9e-01	NA	2.6e-01	NA	9.1e-01
2	METSIM	Adipose	0.0837	0.0334	4.1e-03	-0.001	0.000	0.013	0.002	-0.001	6.6e-01	3.2e-01	3.5e-03	1.4e-01	4.7e-01
3	YFS	Blood	0.0485	0.0142	9.0e-06	0.018	0.019	0.029	0.030	0.028	1.4e-06	6.3e-07	9.3e-10	3.6e-10	9.9e-10

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.7	2.6	5.2	-0.0	1.7	2.3
Bipolar Disorder or Schizophrenia	1.3	3.2	4.5	0.9	2.1	2.1
Depressed Affect (Nagel 2018)	0.8	1.6	4.2	-2.0	0.4	0.7
Depression (Nagel 2018)	1.1	1.7	4.2	0.2	0.9	2.1
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.2	0.0	0.1	0.5
Neuroticism (Nagel 2018)	0.7	1.7	4.8	-2.2	-0.6	-0.1
Schizophrenia (2018)	0.6	1.3	2.1	1.1	1.4	0.9
Schizophrenia vs Biploar Disorder	0.3	0.4	0.6	-0.7	-0.8	0.1
Worry (Nagel 2018)	0.9	2.0	4.2	-2.0	-1.1	-0.8
Alzheimer’s Disease (in mother)	1.8	2.1	6.2	-0.2	-0.3	-2.5
Alzheimer’s Disease (in father)	1.8	1.9	4.5	0.6	-2.1	-0.9
Alzheimer’s Disease (including proxy)	1.9	2.7	5.4	1.4	-1.0	-2.3
Crohns Disease (2017)	0.2	0.4	0.6	0.8	-0.6	0.5
Irritable Bowel Disease (IBD)	0.1	0.3	0.3	-0.6	-0.6	0.4
Ulcerative Colitis (UC)	0.4	0.7	2.2	-1.5	-0.2	0.0
Major Depression (MDD)	2.6	3.1	5.7	-2.4	1.9	-0.1
Reaction Time	0.2	0.3	0.5	-0.2	0.7	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.2	1.0	0.5
Breast Cancer	2.8	6.9	19.2	1.1	-0.5	-4.4
Ovarian Cancer	0.8	1.1	3.3	1.8	0.0	0.1
Prostate Cancer	1.2	1.7	3.3	1.2	-1.8	-0.4
Age at First Birth	0.4	0.6	1.5	-0.4	-0.1	1.2
Bipolar Disorder (2011)	0.4	0.4	0.9	0.9	-0.0	0.6
Body Mass Index (BMI) (2010)	1.0	1.3	2.4	1.2	-0.2	-1.6
Coronary Artery Disease (CAD)	0.8	1.0	2.2	0.6	-1.5	-0.6
Crohns Disease (2012)	0.0	0.0	0.1	0.2	0.2	-0.0
Mean Putamen Volume	0.6	0.7	1.9	-1.4	-0.3	0.1
Fasting Glucose	1.0	1.2	1.6	1.2	-1.3	0.7
HbA1C	0.2	0.2	0.6	0.3	0.3	0.8
HDL Cholesterol	1.3	2.2	5.4	-1.0	-0.5	2.3
LDL Cholesterol	1.9	3.0	4.8	-2.0	0.3	-2.2
Lupus	0.6	0.9	1.9	0.6	0.6	1.4
Neuroticism (2016)	0.5	0.8	1.0	-0.7	1.0	-0.9
Primary Biliary Cirrhosis	0.8	1.1	2.8	-0.8	-0.1	1.7
Rheumatoid Arthritis	0.8	1.1	2.7	-0.7	-0.2	1.6
Schizophrenia (2014)	1.1	2.5	4.1	1.3	2.0	1.3
Triglycerides	0.1	0.1	0.4	0.0	0.3	-0.6
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.6	-0.7	0.2	0.1
Ulcerative Colitis	0.8	1.2	3.0	-1.7	-0.6	-0.4
Blood Eosinophil Count	0.1	1.1	1.6	0.6	1.3	-1.2
Blood Platelet Count	0.0	0.2	0.6	0.1	-0.7	-0.3
Blood Red Count	0.3	2.8	7.3	-2.7	-0.3	-1.1
Blood White Count	0.4	2.8	5.1	2.2	1.7	0.8
Heel T-Score	0.2	1.4	3.7	0.7	-1.9	-0.0
BMI	0.5	2.7	7.9	0.5	0.1	-2.8
Height	2.5	47.5	139.2	-11.8	1.8	-0.1
Waist Hip Ratio (WHR)	0.5	2.2	3.4	-1.3	-1.9	1.2
Systolic Blood Pressure	0.2	1.0	2.2	0.8	0.0	1.5
Smoking Status	0.4	1.0	1.4	-1.2	1.2	0.5
Allergy or Eczema	0.4	1.0	1.8	0.0	-1.3	-1.2
Cardiovascular Disease	0.2	0.7	1.3	-0.5	0.7	-1.2
Hypothyroidism (self reported)	0.6	1.5	2.9	-0.9	1.7	-0.8
Respiratory disease	0.1	0.3	0.6	-0.8	0.4	-0.1
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.3	0.2	0.7	-1.5
Lung FEV1/FVC ratio	3.9	19.8	59.4	7.7	-0.1	-0.2
Lung FVC	1.0	4.9	10.6	-3.3	1.0	-1.8
Neuroticism	0.3	0.6	1.6	-1.3	-0.5	-0.3
Chronotype (morning person)	0.0	0.1	0.2	-0.0	-0.1	-0.5
Hair Pigment	0.2	6.9	13.9	2.3	1.1	3.7
Tanning	0.1	1.4	2.9	0.6	-0.9	-1.7
Hand grip strength (left)	0.5	1.2	2.7	-1.6	0.2	-1.0
Number of treatments/medications taken	0.6	1.1	3.0	0.2	0.5	-1.7
Average weekly spirits intake	0.8	1.0	2.0	0.5	0.8	1.4
Sensitivity / hurt feelings	1.9	3.2	5.6	-0.8	-2.4	-1.8
Frequency of depressed mood in last 2 weeks	2.0	2.8	7.7	0.8	0.2	2.8
Hearing difficulty/problems: Yes	1.0	1.6	3.4	-1.8	-1.1	0.2
Relative age of first facial hair	0.6	1.2	3.2	1.8	0.7	-0.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	0.0	0.2	0.6
Ever used hormone-replacement therapy (HRT)	1.3	1.7	4.2	-0.7	2.1	-0.5
Ever had hysterectomy (womb removed)	0.8	0.9	2.2	0.4	-0.6	1.5
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.1	0.3	0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.3	0.6	0.6	-0.4
Angina	1.2	1.6	2.1	-1.4	-1.4	-0.9
Medication for hormone replacement therapy	0.7	0.8	1.5	-1.2	0.1	-1.0
Vitamin and mineral supplements	1.3	1.7	2.6	-1.6	-1.4	-0.7
Supplements: Zinc	0.2	0.2	0.5	-0.3	-0.7	-0.1
Medication: Co-codamol	0.4	0.5	0.5	0.7	0.7	-0.7
Medication: Metformin	0.1	0.1	0.2	-0.4	0.4	-0.1
Diabetes (father)	0.3	0.4	0.5	0.6	0.5	-0.7
Diabetes (mother)	1.0	1.3	2.3	-1.0	0.8	-1.5
Severe depression (siblings)	0.2	0.2	0.3	0.5	-0.5	0.3
Pack years adult smoking proportion	0.0	0.0	0.1	-0.1	-0.2	-0.3
Impedance of leg (right)	0.8	3.7	9.6	-1.0	0.7	3.1
Leg fat-free mass (left)	0.7	3.5	7.1	-2.7	0.7	-1.7
Trunk fat percentage	0.4	1.7	5.1	-0.1	2.3	-0.2
Hand grip strength (right)	1.2	3.2	6.6	-2.6	1.1	-1.3
Townsend deprivation index at recruitment	0.4	0.5	1.0	1.0	-0.7	-0.1
Current tobacco smoking	1.1	1.8	3.0	-0.3	1.7	1.6
Average weekly fortified wine intake	0.4	0.5	1.2	-0.3	-1.1	0.5
Maternal smoking around birth	3.8	5.5	12.6	-0.6	-1.9	-3.5
Fed-up feelings	0.7	1.3	3.6	-1.9	0.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	4.5	0.6	2.1	2.0
Relative age voice broke	0.8	1.3	3.5	1.9	0.5	0.0
Taking other prescription medications	1.9	3.0	3.3	-1.6	1.8	-1.7
Age when periods started (menarche)	0.1	0.3	0.7	-0.8	0.4	0.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.5	-0.4	0.8	1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.7	1.5	-1.6	-1.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	-0.1	-0.7	-0.4
Qualifications: CSEs or equivalent	0.2	0.3	0.5	-0.6	0.7	0.0
Serious illness, injury or assault to yourself	1.4	1.7	4.5	0.8	-0.0	-2.1
High blood pressure	0.4	1.0	2.4	0.3	-0.7	-1.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.1	-0.1	-1.1	-0.4
Multivitamins +/- minerals	2.5	3.1	5.9	1.7	2.4	0.8
Stomach or abdominal pain in last month	0.7	0.8	1.3	0.7	1.2	-0.8
Supplements: Glucosamine	1.2	1.6	2.4	1.5	0.4	-1.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	1.6	0.9	1.2	-0.9
Medication: Atenolol	0.0	0.0	0.0	0.1	0.0	0.1
Medication: Levothyroxine sodium	0.6	1.1	2.4	-0.6	1.6	-0.7
Sitting height	2.2	15.5	45.7	-6.8	0.9	0.0
Chronic bronchitis/emphysema (father)	4.6	5.4	5.9	-2.4	-2.1	-2.4
High blood pressure (mother)	1.2	1.6	4.5	2.1	0.1	0.6
Body mass index (BMI)	0.6	2.5	3.8	1.3	1.4	-1.9
Impedance of leg (left)	0.7	3.6	8.7	-1.4	0.4	3.0
Leg predicted mass (left)	0.7	3.6	7.3	-2.7	0.7	-1.7
Trunk fat mass	0.5	2.2	5.2	-1.0	2.3	-0.7
Waist circumference	0.2	0.6	1.3	-0.4	1.1	-0.5
Number of incorrect matches in round	0.3	0.5	1.4	0.2	1.2	0.0
Past tobacco smoking	1.0	1.8	5.2	2.3	-0.1	0.3
Alcohol usually taken with meals	0.6	0.9	2.2	-0.3	-1.5	-0.8
Nervous feelings	0.1	0.3	0.7	-0.4	0.8	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.0	-0.3	-0.1	-1.0
Hearing difficulty/problems with background noise	1.4	2.2	3.3	-1.8	-1.6	-0.8
Hair/balding pattern: Pattern 2	0.7	0.9	2.1	-1.4	-0.3	0.7
Had menopause	0.1	0.1	0.2	0.2	0.4	0.1
Had other major operations	0.2	0.2	0.6	0.3	-0.2	-0.8
Forced vital capacity (FVC)	3.0	11.6	33.1	-5.8	1.1	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.4	5.8	2.4	-0.8	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	-0.2	-0.5	0.6
Qualifications: None of the above	0.5	1.1	2.0	-1.4	-0.1	-1.1
Financial difficulties in last 2 years	0.3	0.4	0.5	-0.6	0.6	-0.7
Mouth/teeth dental problems	0.5	0.7	1.9	-0.2	0.3	1.4
Heart attack	2.8	3.6	9.6	-0.2	-1.1	-3.1
Allergy	0.2	0.4	0.9	0.9	0.5	0.3
Pain all over the body in last month	1.4	1.5	2.0	-0.8	1.4	1.4
Diabetes (self-reported)	0.5	0.8	1.4	0.9	1.2	-0.3
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.9	0.2	-0.2	-2.0
Medication: Ramipril	0.6	0.8	2.2	0.2	-1.5	0.5
Medication: Simvastatin	0.1	0.1	0.2	-0.5	0.2	-0.3
Fluid intelligence score	0.6	1.2	3.6	0.1	-0.2	1.9
Illnesses of siblings	0.7	0.9	2.5	0.5	-1.6	-0.3
Neuroticism score	0.4	0.9	2.3	-1.5	-0.4	-0.4
Weight	0.6	2.9	3.6	-1.9	1.9	-1.3
Impedance of arm (right)	0.3	1.5	3.9	-0.6	-0.4	2.0
Arm fat percentage (right)	0.6	2.3	3.5	1.3	1.9	-1.3
Trunk fat-free mass	1.0	5.6	13.8	-3.7	0.7	-1.6
Hip circumference	0.6	2.5	6.1	-0.9	2.5	-0.7
Time employed in main current job	0.2	0.2	0.5	0.3	-0.7	-0.4
Alcohol intake versus 10 years previously	2.0	2.9	4.6	-0.4	-2.0	-2.1
Father’s age at death	0.6	0.8	1.3	0.4	1.1	1.0
Worrier / anxious feelings	1.5	2.9	5.7	-1.4	-1.0	-2.4
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.2	-0.5	2.1	-0.7
Falls in the last year	0.6	0.8	1.5	0.8	0.6	1.2
Hair/balding pattern: Pattern 3	1.1	1.6	2.8	1.2	-1.7	0.8
Number of live births	1.1	1.5	2.1	-1.5	-1.3	-0.8
Forced expiratory volume in 1-second (FEV1)	1.2	4.1	11.3	-3.4	0.3	-1.0
Pulse rate	0.1	0.2	0.5	0.0	0.7	-0.2
Happiness	1.9	2.2	3.9	-0.1	-1.7	-2.0
Noisy workplace	1.4	1.8	3.9	-1.2	0.1	-2.0
Qualifications: A levels/AS levels or equivalent	0.5	1.1	2.5	0.4	1.6	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	-0.5	-1.4	-0.7
Mouth/teeth dental problems: Dentures	0.3	0.5	1.4	1.2	0.3	-0.0
Asthma	0.5	1.1	2.6	-1.6	-0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.1	0.4	-0.8
Medication: Cholesterol lowering	0.1	0.1	0.1	0.3	-0.3	-0.2
Depression (self-reported)	0.9	1.1	2.7	-1.7	0.7	-0.4
Medication: Lansoprazole	1.3	1.5	1.7	1.3	-1.1	-1.2
Prospective memory result	0.8	1.0	2.0	0.8	1.4	-0.6
Lung cancer (father)	0.1	0.1	0.2	0.2	0.4	-0.5
Illnesses of mother	0.3	0.4	0.5	-0.7	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	7.1	-2.7	0.7	-0.3
Pulse wave Arterial Stiffness index	1.8	2.1	6.0	-2.5	-0.1	-0.6
Impedance of arm (left)	0.4	1.8	4.5	-0.8	0.4	2.1
Arm fat mass (right)	0.4	1.7	3.6	0.1	1.9	-1.2
Trunk predicted mass	1.0	5.5	13.2	-3.6	0.7	-1.6
Standing height	1.9	18.9	53.0	-7.3	1.4	1.4
Length of working week for main job	3.1	3.4	8.4	0.5	-1.2	-2.9
Exposure to tobacco smoke at home	1.3	1.4	3.4	-0.9	0.3	-1.9
Breastfed as a baby	0.2	0.2	0.5	0.4	-0.2	0.7
Tense / ‘highly strung’	0.8	1.4	2.9	-1.0	-0.5	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.2	-0.6	1.1	-0.5
Hair/balding pattern: Pattern 4	0.3	0.8	1.7	0.2	1.3	0.7
Birth weight of first child	0.1	0.2	0.4	-0.4	-0.6	0.2
Peak expiratory flow (PEF)	0.2	0.5	1.2	0.3	-1.1	-0.4
Pulse wave reflection index	0.5	0.6	1.3	-0.3	-0.7	-1.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	-0.5	0.1
Loud music exposure frequency	0.5	0.6	1.0	-0.8	-0.4	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	1.6	1.3	0.9	1.1
Mouth/teeth dental problems: Bleeding gums	1.1	1.5	4.4	0.0	-0.1	-2.1
Blood clot in the leg (DVT)	1.8	2.3	6.1	-2.5	-0.5	-0.8
Medication: Paracetamol	0.1	0.1	0.2	-0.2	0.4	-0.0
Headache pain in last month	0.5	0.8	2.0	0.5	-0.5	-1.4
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	0.3	-0.6	1.1
Glaucoma (self-reported)	0.2	0.2	0.4	-0.2	0.4	0.6
Gout (self-reported)	0.0	0.0	0.1	0.3	0.2	-0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	1.8	-1.2	1.4	-0.4
Medication: Amlodipine	0.5	0.7	1.3	1.1	0.9	0.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.1	-0.2	-1.1	0.9
Birth weight	0.7	1.4	4.1	-2.0	0.3	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	0.7	-0.0	-0.9
High blood pressure (siblings)	0.7	1.0	2.3	0.8	1.5	-0.4
Forced vital capacity (FVC), Best measure	2.6	9.4	26.1	-5.1	1.4	-0.0
Body fat percentage	0.5	2.1	5.9	0.3	2.4	-0.6
Leg fat percentage (right)	0.5	1.8	3.9	0.9	2.0	-0.9
Arm fat-free mass (right)	0.9	4.6	10.5	-3.2	1.1	-1.4
Exposure to tobacco smoke outside home	0.4	0.6	1.6	-0.0	-0.3	-1.3
Comparative body size at age 10	0.4	1.1	3.1	0.1	0.4	1.8
Number of full brothers	1.0	1.3	2.0	-0.7	1.4	1.2
Worry too long after embarrassment	0.6	0.9	2.0	-0.6	-0.6	-1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.9	-0.3	0.9	1.7
Wheeze or whistling in the chest in last year	2.3	4.2	6.9	-2.6	-0.8	-2.2
Number of children fathered	1.7	1.9	2.5	-1.5	-1.0	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.5	-0.1	-0.5
Age at first live birth	1.3	2.2	3.4	-1.8	1.1	1.5
Pulse wave peak to peak time	1.3	1.6	4.0	2.0	0.2	0.8
Health satisfaction	0.1	0.1	0.3	-0.2	-0.6	-0.1
Shortness of breath walking on level ground	0.1	0.1	0.4	-0.2	-0.0	-0.6
Qualifications: College or University degree	0.2	0.7	1.2	1.0	1.1	0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.2	-0.1	-0.5
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.1	1.0	-0.7	-0.8
Emphysema/chronic bronchitis	1.4	1.6	3.5	-0.6	1.9	0.9
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.8	0.1	1.3
Neck or shoulder pain in last month	0.6	0.8	1.3	1.1	-0.8	0.7
Medication: Blood pressure	0.3	0.5	0.5	0.7	0.7	-0.7
Angina (self-reported)	1.1	1.4	2.4	-1.5	-1.1	-0.8
Migraine (self-reported)	0.4	0.4	0.6	-0.5	0.8	-0.7
Medication: Ibuprofen	0.1	0.1	0.1	0.3	0.4	-0.0
Medication: Allopurinol	0.2	0.3	0.8	0.2	-0.9	-0.2
Medication: Omeprazole	0.6	0.7	1.6	0.6	1.3	-0.1
Medication: Seretide 50 evohaler	0.7	0.8	1.8	-1.4	-0.1	0.7
Mean time to correctly identify matches	0.0	0.0	0.0	-0.1	0.1	0.1
Heart disease (mother)	0.4	0.5	0.8	-0.4	0.9	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	-0.5	0.4	0.4
Whole body fat mass	0.5	2.1	5.1	-0.6	2.3	-0.9
Leg fat mass (right)	0.5	1.8	3.3	-0.5	1.8	-1.4
Arm predicted mass (right)	1.1	5.6	12.3	-3.5	1.3	-1.7
Pulse rate, automated reading	0.4	1.3	3.5	1.9	0.3	-0.4
Alcohol intake frequency.	0.6	1.3	2.6	1.1	0.4	-1.6
Comparative height size at age 10	2.4	13.1	37.3	-6.1	0.2	-1.4
Number of full sisters	0.4	0.5	0.8	0.6	-0.9	-0.6
Suffer from ‘nerves’	0.8	1.2	3.3	-1.8	-0.3	-0.4
Overall health rating	0.3	0.6	0.9	-0.6	-0.8	-0.9
Chest pain or discomfort	0.9	1.2	1.6	1.3	-1.2	0.8
Had major operations	0.3	0.4	0.7	-0.1	0.6	0.8
Age at last live birth	1.9	2.8	3.7	-1.7	1.9	1.4
Family relationship satisfaction	0.9	1.1	2.9	0.4	-1.7	0.6
Leg pain on walking	0.2	0.3	0.6	0.8	0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.7	0.1	-0.8	0.7
Commuting to job workplace: Car/motor vehicle	1.1	1.3	3.5	-1.9	0.3	0.5
Illness, injury, bereavement, stress in last 2 years	2.2	2.6	7.4	-0.3	0.7	2.7
Medication: Aspirin	2.8	3.7	6.4	-1.9	-1.1	-2.5
Supplements: Vitamin C	0.1	0.1	0.2	0.4	0.1	0.1
Knee pain experienced in last month	0.9	1.3	1.8	1.3	-0.7	-1.4
Hypertension (Self-reported)	0.3	0.7	2.0	0.0	-0.4	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.1	0.9	0.1	-1.5
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.3	-0.5	-0.3
Illnesses of siblings: Diabetes	1.7	2.1	3.8	1.3	1.9	1.0
Smoking status: Previous	1.4	2.1	5.0	-2.2	-0.0	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.4	2.8	7.0	-2.6	0.9	-0.8
Whole body fat-free mass	0.9	4.9	11.7	-3.4	0.8	-1.6
Leg fat-free mass (right)	0.7	3.8	8.1	-2.8	0.7	-1.7
Arm fat percentage (left)	0.7	2.6	4.4	1.2	2.1	-1.5
Average weekly red wine intake	0.6	0.8	1.7	-0.9	-1.3	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.3	-0.5	0.1
Mood swings	1.2	2.2	5.2	-2.3	-0.7	-0.9
Loneliness, isolation	1.2	1.7	3.1	1.3	1.8	0.3
Long-standing illness, disability or infirmity	0.3	0.5	0.9	0.7	1.0	-0.2
Ever had bowel cancer screening	1.5	1.7	3.0	-1.7	-0.0	1.5
Diabetes diagnosed by doctor	0.5	0.8	1.1	1.1	0.8	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.5	-0.9	0.5
Friendships satisfaction	0.6	0.7	1.7	0.7	-1.3	-0.2
Qualifications: nursing, teaching	0.4	0.6	1.2	0.6	0.5	1.1
Commuting to job workplace: Walk	0.2	0.2	0.3	0.5	0.3	0.5
Eye problems/disorders: Cataract	0.1	0.1	0.3	0.2	-0.5	0.3
Mouth/teeth dental problems: Mouth ulcers	2.1	3.4	6.3	-1.0	-1.7	-2.5
Medication for cholesterol	0.6	0.9	2.6	0.3	-0.2	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.8	2.1	4.0	-1.4	-0.6	2.0
Back pain experienced in last month	1.1	1.6	2.5	-0.1	-1.6	-1.6
Mineral and other dietary supplements	1.3	1.7	4.4	-0.8	0.4	2.1
Breast cancer (self-reported)	0.5	0.6	0.9	0.9	0.4	0.9
Asthma (self-reported)	0.6	1.3	2.6	-1.6	-0.4	-1.0
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.4	0.6	-0.3
Osteoarthritis (self-reported)	1.0	1.2	2.9	-0.5	1.7	0.8
Medication: Aspirin	2.7	3.5	6.7	-1.6	-1.0	-2.6
Medication: Gliclazide	1.4	1.6	3.6	0.5	0.9	1.9
Illnesses of father: None of the above (group 1)	1.8	2.3	5.6	0.7	0.9	2.4
Smoking status: Current	1.3	2.0	3.0	-0.5	1.7	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	0.9	-1.0	-0.2	-0.5
Whole body water mass	0.8	4.7	10.6	-3.3	0.9	-1.6
Leg predicted mass (right)	0.7	3.8	8.4	-2.9	0.7	-1.6
Arm fat mass (left)	0.5	2.1	3.7	0.3	1.9	-1.6
Number of self-reported non-cancer illnesses	0.4	0.7	1.3	0.0	0.8	-1.1
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.5	0.1	0.6
Miserableness	0.2	0.3	0.9	-0.1	0.3	0.9
Guilty feelings	0.1	0.2	0.6	-0.2	-0.1	0.7
Wears glasses or contact lenses	0.1	0.1	0.3	-0.5	0.4	0.1
Ever taken oral contraceptive pill	0.1	0.1	0.3	0.5	0.1	0.1
Hearing aid user	0.6	0.6	1.4	-0.4	0.6	-1.2
Mother’s age at death	1.1	1.4	3.1	1.0	-0.1	1.8
Financial situation satisfaction	1.7	2.1	3.6	-1.9	-0.6	-1.5
Tinnitus: Yes, now most or all of the time	4.2	4.9	8.3	2.3	1.1	2.9
Commuting to job workplace: Public transport	0.3	0.4	0.6	0.7	0.0	-0.8
Eye problems/disorders: Glaucoma	0.9	1.1	2.4	0.9	0.4	1.6
Medication: Blood pressure	0.4	0.7	1.1	-0.3	-1.0	-1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.1	-0.6	-1.1	-0.4
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.1	0.2	-1.4	-1.4
High cholesterol (Self-reported)	1.1	2.0	4.1	-1.3	-0.2	-2.0
Medication: Bendroflumethiazide	0.2	0.2	0.6	-0.8	0.3	0.3
Medication: Paracetamol	0.4	0.7	1.1	-1.0	0.9	-0.3
Medication: Lisinopril	0.0	0.0	0.1	-0.0	0.3	0.2
Medication: Atorvastatin	1.5	1.8	4.2	-1.2	-0.0	-2.0
Illnesses of father: High blood pressure	0.5	0.6	0.7	-0.6	0.8	-0.9
Alcohol drinker status: Never	0.2	0.2	0.5	0.1	0.1	0.7
Ever smoked	1.4	2.4	7.2	-2.7	-0.2	0.2
Basal metabolic rate	0.8	4.2	9.3	-3.0	1.0	-1.5
Leg fat percentage (left)	0.5	1.8	3.7	0.8	1.9	-1.1
Arm fat-free mass (left)	0.7	3.6	8.2	-2.9	1.1	-1.2
Number of operations (self-reported)	0.5	0.7	1.2	-0.1	0.9	1.1
Average weekly beer plus cider intake	0.0	0.1	0.1	-0.1	-0.1	-0.4
Irritability	0.4	0.7	1.2	-1.1	0.9	-0.0
Risk taking	0.4	0.6	1.4	-0.2	-0.7	-1.2
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.6	-0.3	-0.0
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.5	-0.1	0.9
Age started oral contraceptive pill	0.4	0.5	0.8	-0.9	0.4	-0.7
Diastolic blood pressure, automated reading	0.0	0.0	0.0	0.2	0.2	0.0
Ever depressed for a whole week	0.9	1.1	2.5	1.6	0.5	-0.7
Unable to work because of sickness or disability	0.6	0.8	1.2	1.1	-1.0	0.4
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.0	0.2	0.3
Myopia	0.5	0.7	0.9	-0.6	-0.9	-0.9
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.3	-0.1	0.2	1.1
Cholesterol lowering medication	1.6	2.3	4.2	-1.6	0.2	-2.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.0	0.6	1.4	0.1
Pain experienced in last month	0.7	1.2	2.1	-1.5	1.2	0.4
Supplements: Calcium	0.3	0.3	0.6	0.8	0.6	-0.1
Basal cell carcinoma (self-reported)	8.8	10.5	13.4	3.7	3.1	2.9
Heart attack/myocardial infarction (self-reported)	2.6	3.3	8.8	-0.2	-1.1	-3.0
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	5.4	-2.3	-0.2	-1.1
Heart disease (siblings)	0.8	0.9	2.5	-1.6	0.4	0.4
Alcohol drinker status: Previous	0.2	0.2	0.4	-0.6	0.1	-0.6
Pack years of smoking	0.1	0.1	0.2	-0.5	-0.3	-0.3
Impedance of whole body	0.6	3.0	8.0	-0.9	0.4	2.8
Leg fat mass (left)	0.5	1.8	3.0	-0.6	1.7	-1.4
Arm predicted mass (left)	0.7	3.5	8.1	-2.9	0.8	-1.3