Hub : Genes

RCSD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1340	0.0440	1.5e-03	0.099	NA	0.078	NA	0.088	1.8e-08	NA	5.7e-07	NA	1.2e-07
2	GTEx	Breast Mammary Tissue	0.3560	0.0750	2.5e-05	-0.005	NA	0.018	NA	0.002	8.5e-01	NA	3.7e-02	NA	2.4e-01
3	GTEx	Esophagus Muscularis	0.2550	0.0630	2.0e-05	0.139	NA	0.156	NA	0.146	8.7e-09	NA	9.5e-10	NA	3.4e-09
4	GTEx	Lung	0.1415	0.0452	1.1e-03	0.052	NA	0.072	NA	0.074	7.6e-05	NA	3.4e-06	NA	2.4e-06
5	GTEx	Thyroid	0.2340	0.0640	3.8e-04	0.049	NA	0.035	NA	0.042	1.2e-04	NA	1.0e-03	NA	3.6e-04
6	GTEx	Whole Blood	0.0890	0.0360	6.7e-03	0.055	NA	0.037	NA	0.035	7.6e-06	NA	2.4e-04	NA	3.2e-04
7	METSIM	Adipose	0.0530	0.0203	3.4e-03	0.001	0.019	0.000	0.015	0.002	1.9e-01	5.6e-04	3.4e-01	2.0e-03	1.7e-01
8	NTR	Blood	0.0729	0.0170	1.8e-08	0.010	0.028	0.023	0.029	0.028	2.3e-04	2.4e-09	3.9e-08	8.2e-10	1.5e-09
9	ROSMAP	Brain Pre-frontal Cortex	0.0858	0.0282	4.4e-04	-0.002	0.024	0.010	0.021	0.002	9.7e-01	3.8e-04	1.7e-02	8.8e-04	1.9e-01
10	YFS	Blood	0.1342	0.0200	0.0e+00	0.115	0.119	0.138	0.132	0.132	1.3e-35	1.1e-36	5.7e-43	4.9e-41	8.9e-41

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.6	2.1	-0.6	-1.2	-0.3	-0.4	-1.4	-0.5	0.3	0.1	-0.3	1.4
Bipolar Disorder or Schizophrenia	0.2	0.6	4.1	-0.1	0.5	0.3	-0.3	-0.3	-0.2	-0.4	-1.0	2.0	-0.5
Depressed Affect (Nagel 2018)	0.3	0.6	3.0	-0.2	0.6	-0.5	-0.6	-0.4	1.1	-0.2	0.3	1.7	-0.5
Depression (Nagel 2018)	0.7	1.0	5.2	-0.2	-0.1	-0.4	-0.1	0.6	1.8	0.9	0.5	2.3	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.7	2.6	-0.3	-0.7	1.6	-0.6	-1.0	0.6	0.0	0.4	-1.2	0.6
Neuroticism (Nagel 2018)	0.5	1.2	5.8	-0.5	0.8	-2.0	-0.3	-0.5	0.4	-0.1	-0.1	2.4	-1.0
Schizophrenia (2018)	0.8	1.7	8.2	0.3	1.6	0.6	-0.1	0.7	-0.0	-0.7	-1.4	2.9	-1.7
Schizophrenia vs Biploar Disorder	3.4	4.5	11.6	1.1	3.3	2.3	0.3	2.2	1.8	2.0	0.9	3.4	-1.7
Worry (Nagel 2018)	0.5	1.0	5.5	-0.4	0.3	-2.3	0.4	-0.3	-0.4	0.5	0.6	1.8	0.2
Alzheimer’s Disease (in mother)	0.6	0.7	3.0	-0.8	0.2	0.0	-1.5	-0.8	-1.7	-0.2	0.4	0.4	0.6
Alzheimer’s Disease (in father)	1.6	1.7	7.2	1.3	1.4	2.7	-0.0	0.8	0.8	0.6	0.5	2.0	-0.7
Alzheimer’s Disease (including proxy)	0.7	1.1	3.8	0.6	0.7	2.0	-0.8	0.5	-0.3	0.5	1.5	1.5	0.6
Crohns Disease (2017)	0.3	0.8	3.6	-0.2	0.3	-0.2	0.8	0.0	0.3	-1.4	-0.4	-0.9	-1.9
Irritable Bowel Disease (IBD)	0.5	1.2	4.5	-0.7	1.0	-0.1	0.0	-0.7	-0.6	-1.4	-1.6	-1.1	-2.1
Ulcerative Colitis (UC)	0.6	1.2	4.2	-0.9	1.2	0.1	-0.5	-0.9	-1.2	-0.7	-2.0	-0.7	-1.4
Major Depression (MDD)	1.1	1.4	3.7	1.0	-0.2	-0.1	0.9	0.7	1.0	1.2	1.7	-1.6	1.9
Reaction Time	0.3	0.6	2.9	-0.3	-0.3	0.6	-1.7	-0.1	-1.2	0.1	0.8	-0.7	0.4
Verbal and Numeric Reasoning (VNR)	0.7	1.8	5.7	-2.2	-0.8	0.8	-2.4	-1.8	-1.1	-0.1	0.1	-1.2	0.2
Breast Cancer	0.6	1.4	4.8	1.8	2.2	1.2	0.8	0.3	1.0	-0.8	-0.5	0.9	-1.1
Ovarian Cancer	0.4	0.5	1.3	0.7	0.8	1.1	-0.5	1.1	-0.2	0.5	0.6	-0.0	0.4
Prostate Cancer	0.5	0.7	2.5	-0.4	0.6	0.3	-0.1	-1.2	-0.0	-1.1	-1.0	0.1	-1.6
Age at First Birth	0.9	1.3	4.5	-1.6	0.4	-1.3	-0.3	-0.8	-1.3	-2.1	0.4	-1.2	0.4
Bipolar Disorder (2011)	0.2	0.2	1.0	0.5	-0.2	-0.4	1.0	-0.3	0.2	0.1	-0.4	0.7	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-1.2	-0.1	0.5	-1.3	0.0	0.2	-0.0	-0.1	-0.4	-0.8
Coronary Artery Disease (CAD)	0.4	0.4	1.4	0.3	0.3	-0.5	0.8	-0.4	-0.6	0.0	-1.2	0.7	-0.9
Crohns Disease (2012)	0.4	0.6	2.1	0.8	0.3	-0.3	1.0	-0.1	-0.7	-1.3	0.2	0.5	-1.5
Mean Putamen Volume	0.5	0.6	3.1	-0.2	-0.4	0.7	-0.7	-0.4	0.2	1.0	-0.4	1.8	-0.2
Fasting Glucose	0.7	0.8	2.6	-1.6	-1.0	-0.8	-0.6	-0.4	-0.3	-1.4	0.3	-0.7	-0.7
HbA1C	1.9	2.1	6.1	1.8	0.3	-0.0	1.8	0.4	1.8	2.5	1.0	-0.4	2.0
HDL Cholesterol	0.1	0.2	0.8	0.1	-0.6	-0.9	0.1	-0.0	0.3	-0.2	-0.0	0.2	-0.6
LDL Cholesterol	0.3	0.4	1.1	-0.8	-0.6	0.8	-0.9	-0.3	0.0	0.4	-0.4	0.4	-1.0
Lupus	2.4	3.7	13.5	0.1	0.5	0.6	0.2	1.5	0.7	3.5	2.7	-0.5	3.7
Neuroticism (2016)	0.8	1.2	3.8	0.6	0.6	-0.8	0.2	1.7	1.9	0.2	0.9	1.6	-0.1
Primary Biliary Cirrhosis	0.3	0.4	1.2	0.5	0.6	0.5	0.4	-1.1	0.8	-0.3	0.6	-0.5	0.4
Rheumatoid Arthritis	2.1	2.9	6.5	1.0	-2.5	-0.3	1.0	1.0	1.8	2.0	1.8	1.7	2.5
Schizophrenia (2014)	0.5	1.1	6.9	0.3	1.5	0.5	-0.6	0.2	0.7	0.4	-0.4	2.6	-0.7
Triglycerides	0.9	1.5	3.8	1.1	0.2	1.9	0.3	0.6	0.1	2.0	1.7	-0.1	1.8
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.2	0.7	-0.4	-1.1	0.7	-0.0	0.5	-0.9	0.1	0.0	0.1
Ulcerative Colitis	0.6	0.8	1.8	-0.2	0.6	0.2	0.5	-1.1	-1.2	-1.3	-1.1	-0.4	-1.3
Blood Eosinophil Count	0.2	1.5	7.5	-0.5	-0.9	1.5	0.0	-0.5	-0.2	1.8	-0.5	2.7	-0.2
Blood Platelet Count	0.2	2.6	8.8	-2.1	1.1	-0.4	-3.0	-1.0	-1.9	0.2	0.8	-0.3	2.5
Blood Red Count	0.4	3.8	6.6	-2.2	-1.0	2.0	-2.1	-0.8	-1.3	-2.6	-2.5	-2.0	-2.0
Blood White Count	2.3	16.9	49.3	7.0	3.3	1.9	5.8	4.1	5.9	1.8	1.9	3.4	-0.9
Heel T-Score	0.2	1.4	6.5	0.3	-1.2	2.5	-1.0	-1.1	-1.5	0.8	0.0	-1.0	0.6
BMI	0.2	1.3	3.3	0.1	0.9	1.7	0.2	-0.4	0.3	-1.7	1.8	-1.6	0.2
Height	0.2	3.1	13.7	-0.8	0.9	-1.3	-0.9	-0.4	0.2	-0.6	2.9	-3.7	2.1
Waist Hip Ratio (WHR)	0.6	2.6	8.8	1.2	-0.5	-2.5	1.4	0.3	0.4	1.0	2.2	-0.9	3.0
Systolic Blood Pressure	0.4	2.0	7.1	-0.6	-0.3	1.9	-0.7	-1.8	-1.0	1.9	-2.7	1.1	0.0
Smoking Status	0.9	2.2	7.5	0.3	-1.4	-0.3	-0.6	0.0	1.9	-0.1	-1.3	2.7	-2.5
Allergy or Eczema	0.6	1.6	6.9	-0.3	0.0	-0.6	0.2	-0.3	-0.1	1.9	1.5	1.6	2.6
Cardiovascular Disease	1.2	4.0	9.4	-2.7	-2.6	1.7	-1.8	-3.1	-2.3	-0.5	-1.8	-0.9	-0.3
Hypothyroidism (self reported)	0.5	1.1	6.1	-0.5	-0.8	0.5	-0.4	-0.2	-1.0	-1.0	-0.8	-2.5	-0.7
Respiratory disease	0.9	2.1	7.4	0.4	-0.6	-1.5	-0.1	-0.1	0.6	2.4	1.6	1.4	2.7
Type 2 Diabetes (T2D) (2018)	0.7	1.2	3.3	-1.8	-1.8	0.9	-1.1	-1.6	-0.7	-0.6	-0.5	-0.6	0.2
Lung FEV1/FVC ratio	0.9	4.3	13.4	-2.2	-0.5	1.1	-2.5	-1.8	-3.7	-0.9	-1.6	-3.2	-0.7
Lung FVC	0.4	1.9	10.5	-0.2	0.5	-0.0	1.1	-0.4	-0.9	-1.4	-3.2	0.1	-2.1
Neuroticism	0.6	1.5	9.3	0.4	1.1	-1.6	0.5	0.5	0.8	0.6	0.3	3.0	-0.7
Chronotype (morning person)	1.2	2.8	7.4	2.7	1.0	1.6	2.6	1.7	1.2	1.7	1.1	1.3	-0.1
Hair Pigment	0.0	1.3	6.0	-0.2	0.4	1.9	0.1	1.1	-0.6	-1.0	0.7	-2.4	0.2
Tanning	0.0	0.4	1.0	-0.2	0.1	0.2	0.5	-1.0	-0.3	0.9	-1.0	-0.4	0.4
Hand grip strength (left)	0.2	0.6	1.3	1.1	0.9	-0.4	1.1	-0.7	0.4	-0.6	-0.5	-1.0	0.2
Number of treatments/medications taken	0.6	1.1	2.4	-1.5	-0.9	1.3	-0.9	-1.0	-0.7	1.4	0.9	-0.1	0.6
Average weekly spirits intake	0.3	0.3	0.7	-0.8	0.0	-0.7	0.7	-0.6	-0.1	-0.6	-0.5	0.6	-0.7
Sensitivity / hurt feelings	0.3	0.5	2.1	0.0	-0.8	-1.4	1.0	0.9	-0.4	0.2	0.2	0.2	-0.6
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.3	-1.1	-0.8	-1.1	0.5	-0.8	0.4	0.3	-0.7	0.5	-0.3
Hearing difficulty/problems: Yes	0.6	0.9	2.4	-0.4	1.4	0.2	-1.1	-0.6	-0.7	-0.4	-1.3	0.4	-1.6
Relative age of first facial hair	0.4	0.9	2.6	0.4	-0.5	-0.2	0.2	-0.8	-1.6	0.7	1.2	-0.8	1.5
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	5.0	-0.8	0.3	1.5	-0.6	0.7	1.2	1.1	1.5	-1.0	2.2
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	0.4	0.4	0.1	0.6	0.6	1.2	0.4	0.3	1.1	-0.7
Ever had hysterectomy (womb removed)	0.6	0.7	3.7	-1.5	-0.7	0.1	-1.9	-0.4	0.0	-0.1	0.2	-0.4	0.2
Systolic blood pressure, automated reading	0.4	1.2	4.8	-0.4	1.1	2.2	-0.8	-1.1	-0.6	0.2	-1.6	0.3	-0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-0.5	-1.2	0.1	-0.1	-0.8	0.4	0.1	-0.2	-0.5	-0.2
Angina	2.7	3.5	9.1	-2.7	-0.2	0.8	-3.0	-2.3	-3.0	-0.9	-1.0	-1.6	-0.1
Medication for hormone replacement therapy	0.6	0.7	3.1	-1.3	-0.8	0.2	0.3	-0.1	0.8	-0.3	0.8	-1.8	0.2
Vitamin and mineral supplements	0.3	0.4	0.9	0.8	-0.6	0.9	0.0	0.9	0.1	0.2	0.6	-0.3	0.7
Supplements: Zinc	1.0	1.0	3.5	0.4	1.5	0.4	0.0	1.9	1.7	1.1	0.2	0.3	-0.2
Medication: Co-codamol	1.8	2.1	9.1	-1.2	-3.0	-1.1	-0.6	0.3	-0.7	-1.2	0.4	-2.3	1.1
Medication: Metformin	1.2	1.8	8.0	-1.4	-2.8	-0.5	-0.0	-1.0	-0.9	-1.5	-1.6	-0.5	-0.9
Diabetes (father)	1.8	2.2	13.1	-1.3	-1.7	-1.7	0.0	-0.0	0.0	-0.4	0.1	-3.6	1.2
Diabetes (mother)	0.4	0.5	1.7	0.4	-1.3	-0.2	0.3	-0.6	1.2	0.0	0.4	-0.9	0.4
Severe depression (siblings)	0.3	0.3	1.1	0.3	-0.2	-0.6	-0.3	-0.5	0.1	0.7	0.7	0.3	1.0
Pack years adult smoking proportion	0.6	0.8	1.6	1.0	-0.4	1.0	1.0	1.3	0.6	1.0	1.1	0.8	0.5
Impedance of leg (right)	0.3	1.6	4.8	-0.1	-1.3	-1.0	-1.4	1.2	0.3	1.6	-1.4	2.2	-0.8
Leg fat-free mass (left)	0.2	1.2	5.0	-0.2	0.6	0.4	0.3	-0.8	-0.2	-2.2	0.8	-2.1	0.2
Trunk fat percentage	0.3	1.1	5.2	0.9	0.5	0.8	0.3	1.3	1.1	-1.0	2.3	-0.1	0.3
Hand grip strength (right)	0.5	1.3	3.5	0.8	0.9	-0.0	0.4	-1.1	-0.3	-1.9	-1.6	1.1	-1.8
Townsend deprivation index at recruitment	0.7	1.0	4.9	-0.6	-2.2	-1.4	0.3	0.1	0.5	-1.4	0.4	-0.6	-0.2
Current tobacco smoking	1.0	1.6	5.1	-0.7	-2.3	-1.9	-0.1	0.1	1.7	-0.2	-0.8	1.1	-1.4
Average weekly fortified wine intake	0.4	0.5	1.3	-0.8	0.5	1.1	-0.0	0.9	0.1	0.5	-0.8	0.6	-1.1
Maternal smoking around birth	0.2	0.3	1.0	-0.2	-1.0	0.2	-0.0	-0.6	-0.3	0.5	0.8	0.4	0.2
Fed-up feelings	0.5	0.9	3.0	-1.7	-1.2	-1.3	-1.1	-1.0	0.3	-0.4	0.3	-0.3	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.2	-0.3	-0.7	-1.8	-0.2	0.3	1.5	0.2	-0.4	1.4	-0.1
Relative age voice broke	3.2	4.8	10.9	3.0	0.7	-0.7	3.0	2.5	2.0	2.0	3.3	0.1	2.1
Taking other prescription medications	0.8	1.2	3.7	-0.5	0.8	0.8	-0.7	-0.9	-1.5	1.7	0.3	0.3	1.9
Age when periods started (menarche)	0.2	0.4	1.6	-0.6	0.8	-0.4	-0.3	1.3	0.2	0.4	0.8	-0.4	0.3
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	8.9	-2.3	0.4	0.3	-3.0	-0.8	-1.2	-0.4	0.1	-1.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.1	0.4	-0.3	-0.0	-0.2	-0.2	0.4	0.3	-0.2	0.2	-0.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	3.1	-0.1	1.2	0.4	-1.2	-0.7	-1.8	-0.1	0.4	0.5	0.4
Qualifications: CSEs or equivalent	0.7	1.0	6.3	0.2	-2.5	-0.3	-0.5	-0.9	1.2	-0.6	0.4	-0.7	0.1
Serious illness, injury or assault to yourself	0.7	0.8	4.6	-0.4	-0.5	0.4	0.7	-0.7	0.3	1.0	1.0	2.1	-0.0
High blood pressure	0.5	1.5	4.0	-1.9	-0.2	1.2	-2.0	-1.7	-0.6	1.1	-0.5	-0.5	0.8
Hayfever, allergic rhinitis or eczema	0.9	2.0	8.6	-0.2	0.3	-1.0	0.2	-0.3	0.3	2.2	1.9	1.1	2.9
Multivitamins +/- minerals	0.7	0.9	2.7	-1.1	0.0	-0.5	-0.6	-1.6	-0.7	0.3	-1.1	0.5	-1.5
Stomach or abdominal pain in last month	0.4	0.5	2.1	-0.5	-1.5	0.4	-1.1	0.2	-0.4	0.4	0.6	0.6	0.6
Supplements: Glucosamine	0.5	0.6	4.6	-0.3	0.4	0.0	0.3	-1.0	-2.1	0.1	-0.1	0.2	-0.6
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.0	-0.5	-1.2	1.4	-1.3	2.0	1.3	0.2	1.3	1.1	-0.3
Medication: Atenolol	0.7	0.9	2.3	0.5	0.3	0.9	-0.4	-1.2	-1.5	0.7	0.9	-0.9	1.4
Medication: Levothyroxine sodium	0.4	0.7	1.9	0.8	-0.3	1.3	0.7	0.9	-0.2	-0.5	-0.8	-0.9	-1.4
Sitting height	0.3	2.0	4.2	-2.0	-0.8	-0.7	-1.6	1.0	0.4	-2.0	-1.3	-1.7	-1.5
Chronic bronchitis/emphysema (father)	1.0	1.2	4.1	-0.6	0.6	0.1	-0.7	-2.0	-2.0	-0.9	-0.5	0.8	-0.6
High blood pressure (mother)	1.0	1.4	6.8	-1.3	0.1	-0.3	-0.7	-2.6	-0.9	-1.8	-0.7	-0.4	-0.8
Body mass index (BMI)	0.2	1.1	3.0	0.3	0.6	1.7	0.5	-0.3	0.2	-1.7	1.7	-0.8	0.3
Impedance of leg (left)	0.3	1.5	4.9	-0.0	-0.8	-0.8	-1.2	1.4	0.6	1.6	-1.2	2.2	-0.7
Leg predicted mass (left)	0.2	1.2	5.0	-0.2	0.6	0.3	0.2	-0.8	-0.2	-2.2	0.8	-2.2	0.2
Trunk fat mass	0.3	1.1	4.9	0.7	0.6	0.7	0.3	0.8	0.8	-1.6	2.2	-0.9	0.5
Waist circumference	0.3	1.2	5.2	0.1	-0.1	0.3	-0.0	-0.2	0.5	-1.3	2.3	-1.4	1.6
Number of incorrect matches in round	0.6	0.9	3.7	-0.3	-0.7	1.1	-0.5	-0.6	-0.3	-0.1	-1.9	0.5	-1.7
Past tobacco smoking	0.8	1.4	9.3	-1.1	0.2	-0.4	-0.3	-0.2	-0.8	-1.0	0.5	-3.0	1.1
Alcohol usually taken with meals	0.5	0.8	3.3	0.9	0.7	0.5	-0.3	1.8	0.3	0.8	0.8	0.6	1.0
Nervous feelings	0.5	1.0	3.0	0.4	1.7	-1.5	1.4	0.2	-0.2	1.3	0.8	0.5	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.7	-1.5	-1.0	-1.9	-0.0	-0.7	0.5	0.7	0.5	0.7	0.1
Hearing difficulty/problems with background noise	0.5	0.8	3.5	-0.2	1.9	0.1	-0.4	-0.7	-1.9	-0.4	-0.0	-0.2	0.4
Hair/balding pattern: Pattern 2	1.0	1.3	6.0	-1.0	2.5	0.1	-0.9	-0.9	0.2	-0.7	0.4	-1.8	0.7
Had menopause	0.6	0.7	2.3	0.1	-1.4	-1.0	0.4	0.7	0.8	0.0	0.8	1.5	-0.5
Had other major operations	0.3	0.3	0.8	-0.6	0.6	0.4	0.1	-0.6	-0.1	0.9	0.6	-0.8	0.5
Forced vital capacity (FVC)	0.2	0.8	2.2	-0.2	-0.1	-1.4	0.1	-1.0	-0.2	-0.9	-1.5	-0.9	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	1.2	1.2	0.7	0.8	-0.2	0.8	0.4	0.3	0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.8	-1.0	-1.2	-0.5	-0.9	-0.9	-0.7	0.3	1.7	-0.1	1.1
Qualifications: None of the above	0.3	0.6	2.1	-0.1	-1.1	-0.0	0.1	0.3	-0.9	-0.9	-0.9	0.1	-1.4
Financial difficulties in last 2 years	0.5	0.7	2.2	-0.8	-1.5	-0.3	0.4	-0.3	0.8	1.4	0.1	0.9	-0.0
Mouth/teeth dental problems	0.2	0.3	1.9	0.4	0.3	-0.0	1.4	0.2	-0.5	0.3	-0.4	-0.5	0.4
Heart attack	1.5	1.9	3.9	-1.3	-0.3	1.0	-0.6	-1.7	-1.6	-1.7	-1.7	-0.5	-2.0
Allergy	0.9	2.0	6.4	-0.2	0.6	1.1	-0.1	-0.5	-0.8	-2.3	-2.1	-1.3	-2.5
Pain all over the body in last month	4.6	5.0	13.8	-2.8	-1.7	-0.4	-3.7	-1.7	-3.1	-1.4	0.2	-3.0	1.0
Diabetes (self-reported)	0.3	0.5	2.1	-0.5	-1.4	1.3	0.1	-0.7	-0.5	0.2	-0.5	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	7.8	1.6	1.8	0.1	1.2	1.9	1.6	2.1	1.5	2.8	0.4
Medication: Ramipril	0.3	0.4	1.3	-0.2	-0.4	0.1	-0.3	-1.0	-0.1	-0.3	-1.1	-0.3	-0.9
Medication: Simvastatin	0.9	1.4	4.0	-1.0	-1.6	0.6	-1.4	-1.6	-2.0	0.5	-0.1	0.9	0.6
Fluid intelligence score	0.7	1.4	3.6	-1.5	-0.4	0.4	-1.6	-1.2	-0.9	0.5	0.9	-1.9	1.4
Illnesses of siblings	1.2	1.7	3.9	2.0	1.9	0.5	1.3	-0.5	0.8	1.6	1.1	-1.1	1.1
Neuroticism score	0.5	1.0	3.5	0.1	0.6	-1.9	0.4	0.2	0.5	0.7	1.1	1.9	0.3
Weight	0.2	1.0	4.3	0.0	0.6	0.9	0.1	-0.3	0.3	-2.1	1.5	-1.5	0.3
Impedance of arm (right)	0.4	1.7	6.3	0.6	-1.0	-1.6	-0.2	1.4	0.8	2.5	0.6	1.8	0.4
Arm fat percentage (right)	0.2	0.7	3.9	0.5	0.4	0.7	0.4	0.2	0.1	-1.1	2.0	-0.4	0.4
Trunk fat-free mass	0.3	1.8	7.9	-0.8	0.6	0.1	-0.2	-1.5	-0.9	-2.8	-0.8	-2.2	-0.6
Hip circumference	0.3	1.1	3.1	-1.1	0.1	1.4	-0.9	-0.3	0.2	-1.8	0.9	-1.6	0.0
Time employed in main current job	1.1	1.3	2.8	-1.7	-0.6	0.1	-1.1	-1.1	-1.3	-1.6	0.8	-0.8	1.3
Alcohol intake versus 10 years previously	0.6	0.8	2.2	-0.3	-0.7	-0.1	-1.1	0.8	1.0	0.7	1.0	-1.1	1.5
Father’s age at death	0.3	0.5	1.6	-0.4	-1.3	-0.5	0.1	0.9	0.8	-0.3	-0.0	0.6	-0.8
Worrier / anxious feelings	0.6	1.2	4.5	0.2	-0.0	-1.0	0.8	1.1	1.0	1.0	2.1	1.2	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	4.7	-0.0	-0.0	-0.1	0.8	-0.1	0.4	2.2	1.0	1.6	1.0
Falls in the last year	0.4	0.5	2.9	-0.4	0.4	-0.2	-0.4	-1.7	-0.8	-0.6	-0.5	0.1	-0.4
Hair/balding pattern: Pattern 3	0.6	0.9	3.8	-0.2	-1.8	-0.1	-1.0	-0.3	-0.4	-2.0	0.3	0.1	-0.2
Number of live births	1.2	1.7	4.6	-0.9	0.8	1.3	-1.4	-0.2	-1.5	-0.2	-2.1	0.9	-2.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.8	-0.4	-0.0	-1.0	-0.2	-1.2	-0.7	-1.2	-1.6	-1.7	-0.8
Pulse rate	0.5	0.9	3.5	-0.1	-0.1	-1.9	1.5	-0.9	0.3	-0.3	-0.7	-1.1	0.6
Happiness	0.7	0.8	3.5	-0.5	-0.4	-0.7	-1.0	-0.9	-0.8	-0.7	-0.6	0.6	-1.9
Noisy workplace	0.7	0.9	4.6	-0.0	-2.1	-0.0	-0.4	-1.1	1.3	1.1	-0.1	0.1	0.4
Qualifications: A levels/AS levels or equivalent	0.8	1.9	9.4	0.9	0.2	-1.3	1.0	0.8	0.5	1.2	1.7	-0.6	3.1
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	2.6	-0.9	0.9	1.3	-0.7	-0.5	-1.4	-0.7	-1.6	1.1	-1.4
Mouth/teeth dental problems: Dentures	0.5	0.9	1.8	0.3	-1.1	1.1	-1.0	0.4	1.3	-0.8	1.1	1.1	-0.2
Asthma	0.7	1.3	3.5	-0.8	-1.9	-1.3	-0.3	-1.4	-0.8	1.6	0.0	1.0	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	2.2	-0.2	1.1	1.5	0.3	-0.6	0.4	0.3	0.0	-0.2	-0.5
Medication: Cholesterol lowering	1.4	2.2	6.6	-1.7	-1.8	0.9	-2.2	-1.3	-2.6	-0.7	-0.9	0.7	-0.4
Depression (self-reported)	0.9	1.1	4.7	-0.8	-2.0	-2.2	0.3	-0.9	-0.3	-0.6	0.6	-0.1	0.4
Medication: Lansoprazole	0.5	0.6	1.8	1.3	-0.3	0.9	0.4	-1.4	-0.2	0.8	0.2	0.4	0.8
Prospective memory result	0.8	0.9	4.2	-2.0	-0.3	-0.5	-1.7	-0.5	-0.7	0.3	-0.8	0.1	-0.6
Lung cancer (father)	1.4	1.6	4.1	-0.4	-1.8	-0.7	-1.0	-0.1	0.1	0.8	1.7	-1.9	2.0
Illnesses of mother	0.2	0.3	1.1	0.2	-0.5	-0.0	0.3	0.8	1.0	0.0	-0.8	-0.4	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.2	-1.0	0.2	-0.7	-1.1	-1.4	-0.8	-1.0	-1.2	-1.8	-0.4
Pulse wave Arterial Stiffness index	1.0	1.2	4.7	-1.2	-1.5	-1.2	-0.5	-1.3	0.6	-0.1	-0.1	-2.2	0.0
Impedance of arm (left)	0.4	1.7	4.7	0.4	-1.1	-2.0	-0.2	1.9	0.8	2.2	0.8	1.5	0.5
Arm fat mass (right)	0.2	0.9	2.9	0.4	0.3	1.1	0.5	0.1	0.1	-1.6	1.7	-1.0	0.3
Trunk predicted mass	0.3	1.8	7.6	-0.9	0.5	0.1	-0.2	-1.5	-0.9	-2.8	-0.8	-2.3	-0.5
Standing height	0.1	0.7	2.5	-0.4	0.2	-1.4	-0.8	0.2	0.3	-1.1	-0.5	-1.6	-0.1
Length of working week for main job	0.5	0.6	2.2	0.6	0.3	-1.0	1.1	-0.2	1.5	0.7	0.2	-0.2	0.4
Exposure to tobacco smoke at home	0.9	1.0	2.6	-0.3	1.3	1.0	0.0	0.1	-1.0	0.0	-1.4	1.3	-1.6
Breastfed as a baby	1.0	1.2	5.5	-2.3	1.1	0.7	-0.8	-0.4	-0.7	-0.5	-0.4	-1.8	0.3
Tense / ‘highly strung’	0.3	0.5	1.3	-0.6	0.4	-1.1	0.1	0.1	-0.3	1.1	0.2	0.6	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	2.7	-0.8	-0.4	-1.5	0.8	-0.8	0.3	1.1	-0.3	1.6	0.2
Hair/balding pattern: Pattern 4	0.3	0.7	2.9	-0.9	1.3	-0.3	-0.2	0.9	-0.0	0.2	0.7	-0.8	1.7
Birth weight of first child	0.3	0.6	1.8	0.8	-0.5	0.7	0.1	0.5	0.6	-1.2	1.3	0.1	0.7
Peak expiratory flow (PEF)	0.3	0.6	2.2	-0.1	0.5	1.0	0.2	-0.6	-1.0	-0.6	-1.5	-1.1	-0.3
Pulse wave reflection index	2.2	2.7	7.5	-2.7	-2.3	-0.8	-1.6	-1.4	-1.0	-0.6	0.2	-2.7	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.6	0.1	-1.2	-0.4	0.8	-0.6	-0.6	-0.6	0.2	0.3	-0.7
Loud music exposure frequency	3.2	3.5	11.6	-1.1	-0.9	-0.9	-0.2	-1.5	-0.7	-2.5	-3.4	1.4	-3.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.9	0.7	0.7	-0.8	-0.0	0.3	0.9	0.6	0.4	-0.6	1.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.9	-1.4	0.2	-0.4	-1.3	-0.2	0.0	-0.4	-0.7	-0.1	-0.6
Blood clot in the leg (DVT)	0.4	0.5	1.6	0.3	-1.3	-1.1	0.4	0.6	-0.1	-0.4	0.0	-1.1	-0.8
Medication: Paracetamol	0.4	0.7	3.9	-1.0	0.4	0.8	0.0	-0.9	0.3	-0.1	0.1	-2.0	-0.3
Headache pain in last month	0.8	1.3	6.3	0.8	-0.9	0.8	0.8	1.1	-0.0	2.5	0.0	-0.2	1.6
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	8.9	1.8	3.0	-0.3	2.2	0.3	2.4	1.0	0.4	0.4	-0.8
Glaucoma (self-reported)	0.6	0.7	3.4	-0.5	0.2	0.2	-1.0	0.5	-0.7	1.1	0.4	-0.6	1.9
Gout (self-reported)	0.6	0.9	4.2	0.2	0.8	1.4	-1.1	-2.0	-0.3	0.5	-0.1	0.2	0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	4.2	0.1	-0.6	0.5	0.6	0.5	-0.3	0.0	-0.3	-2.0	-0.2
Medication: Amlodipine	0.8	1.1	1.8	-1.1	-1.2	0.7	-1.3	-1.4	-0.9	-1.0	-1.2	-0.6	-0.3
Medication: Ventolin 100micrograms inhaler	0.9	1.2	4.6	0.7	-1.4	-1.3	2.2	0.5	1.2	-0.9	-0.5	0.2	-0.8
Birth weight	0.5	1.1	3.2	-0.4	-1.8	-0.2	-1.5	-0.4	-0.9	0.3	1.4	-0.5	1.4
Chronic bronchitis/emphysema (mother)	0.5	0.5	1.9	-1.1	0.2	-0.0	-0.6	-0.4	-1.3	1.4	-0.1	0.2	-0.3
High blood pressure (siblings)	0.7	1.1	3.0	-1.5	-0.7	-0.6	-1.0	0.9	1.0	-0.2	1.1	-0.4	1.7
Forced vital capacity (FVC), Best measure	0.3	1.0	3.0	-0.8	0.2	-1.0	-0.9	-1.7	-0.9	-0.7	-1.2	-1.2	0.0
Body fat percentage	0.2	0.8	3.8	0.7	0.5	0.8	0.2	0.9	0.9	-1.1	2.0	-0.0	0.1
Leg fat percentage (right)	0.2	0.7	2.1	0.4	0.0	1.3	-0.2	0.6	0.5	-1.3	1.4	0.3	-0.3
Arm fat-free mass (right)	0.4	1.9	11.5	-0.5	0.7	0.2	-0.0	-1.1	-0.5	-3.4	-0.5	-2.1	-0.8
Exposure to tobacco smoke outside home	0.7	0.9	4.2	-0.2	2.1	1.1	-0.2	-1.8	-0.7	0.3	-0.0	-0.1	0.2
Comparative body size at age 10	0.5	1.3	4.0	0.8	-0.7	-0.6	0.4	-0.7	-0.1	-1.4	-1.0	1.9	-2.0
Number of full brothers	1.8	2.2	6.9	-2.3	-2.6	-0.0	-0.8	-1.5	0.0	-2.1	-0.5	-1.5	-0.6
Worry too long after embarrassment	0.3	0.5	2.1	-0.4	0.5	-0.2	-0.0	-0.4	-0.0	-0.6	-0.7	1.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.3	0.6	-0.0	-1.2	0.9	1.3	0.2	0.9	1.8	1.1	0.7
Wheeze or whistling in the chest in last year	0.9	1.5	5.1	0.2	-2.3	-0.4	0.6	1.0	0.3	1.7	1.7	0.9	1.5
Number of children fathered	0.6	0.6	1.8	0.6	-0.7	0.8	0.6	0.1	1.3	1.2	0.3	0.7	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.8	1.0	0.3	-0.1	1.1	-0.2	1.0	1.3	0.3	0.7	1.2
Age at first live birth	0.7	1.2	5.5	0.1	0.1	-0.1	0.7	-0.7	-0.3	0.5	1.7	-1.5	2.3
Pulse wave peak to peak time	0.8	0.9	3.6	0.9	1.4	0.9	0.2	1.2	-0.7	-0.1	0.1	1.9	-0.0
Health satisfaction	1.5	2.0	6.2	0.2	-0.9	-0.9	1.3	-0.3	1.5	2.5	1.9	0.3	2.0
Shortness of breath walking on level ground	0.5	0.7	2.2	-1.1	-0.8	-0.5	-1.5	-1.3	0.1	0.4	-0.4	0.3	0.2
Qualifications: College or University degree	0.1	0.5	2.6	0.2	0.1	0.4	0.5	-0.5	-0.1	-0.4	0.7	-0.8	1.6
Eye problems/disorders: None of the above	0.5	0.5	1.8	-0.5	1.3	-0.5	-0.3	-1.3	-0.4	-0.2	-1.0	-0.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.6	0.7	2.2	-1.0	-1.5	-0.7	-1.4	-0.6	-0.0	-0.5	0.3	-0.6	-0.4
Emphysema/chronic bronchitis	1.6	1.8	6.5	0.5	0.1	1.8	-0.8	2.5	1.3	0.8	1.7	-0.3	1.4
Medication for pain relief, constipation, heartburn	0.4	0.6	2.6	1.4	-0.4	-0.8	0.5	1.6	0.1	0.4	-0.4	0.5	-0.1
Neck or shoulder pain in last month	1.2	1.8	3.6	1.6	1.6	0.2	1.0	1.5	1.9	1.8	1.2	0.6	0.7
Medication: Blood pressure	1.0	1.7	4.9	-1.4	-2.1	0.8	-2.2	-0.2	-1.4	0.2	0.1	-1.2	1.3
Angina (self-reported)	2.2	2.8	7.5	-2.4	-0.2	1.1	-2.6	-2.1	-2.7	-0.5	-0.7	-1.3	0.2
Migraine (self-reported)	0.5	0.6	3.3	-0.4	-0.6	0.4	0.3	1.0	-0.8	0.1	-0.2	-1.8	0.6
Medication: Ibuprofen	0.3	0.3	1.9	-0.3	0.6	1.4	-0.1	-0.2	0.8	0.3	-0.1	0.2	-0.4
Medication: Allopurinol	0.4	0.6	2.0	0.4	0.7	0.9	-0.2	-1.4	0.3	1.2	0.1	-0.1	0.8
Medication: Omeprazole	0.7	0.8	1.8	-1.1	-0.3	0.9	-1.1	-0.3	-0.7	1.1	0.8	-0.8	1.3
Medication: Seretide 50 evohaler	1.0	1.2	8.3	-0.0	-1.2	-2.9	0.4	0.3	-0.4	-0.8	-0.7	-0.8	0.0
Mean time to correctly identify matches	0.3	0.7	2.3	-0.4	-0.6	0.2	-1.4	-0.7	-1.5	-0.3	0.7	-0.7	0.3
Heart disease (mother)	0.5	0.6	1.9	0.6	0.6	-0.4	-0.1	0.5	-1.3	-0.6	-0.3	1.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.5	9.2	-1.2	1.2	1.5	-1.8	-1.4	-1.6	0.1	-0.8	3.0	-1.5
Whole body fat mass	0.2	0.9	3.2	0.7	0.7	1.0	0.4	0.6	0.8	-1.6	1.8	-0.7	0.1
Leg fat mass (right)	0.2	0.8	3.9	0.3	0.4	1.3	-0.3	0.1	0.2	-2.0	1.2	-0.6	-0.2
Arm predicted mass (right)	0.3	1.7	9.7	-0.4	0.7	0.3	-0.1	-0.8	-0.5	-3.1	-0.4	-2.1	-0.7
Pulse rate, automated reading	0.5	1.5	2.8	-0.5	-1.4	-1.6	1.5	-1.4	-0.2	0.3	0.7	-1.7	1.6
Alcohol intake frequency.	0.5	1.1	3.5	-0.2	-1.0	-0.7	-0.6	-0.2	-1.5	-1.6	-0.6	-1.9	0.7
Comparative height size at age 10	0.3	1.7	5.6	-0.7	-0.8	-2.4	-1.0	-1.1	-1.5	-1.2	-1.6	-1.4	-0.2
Number of full sisters	0.3	0.3	0.8	0.5	0.2	-0.3	0.6	0.8	0.6	0.9	0.1	-0.4	0.8
Suffer from ‘nerves’	0.7	1.0	4.1	-0.5	1.1	-1.7	0.4	0.7	0.1	0.6	0.1	2.0	-1.0
Overall health rating	0.5	1.0	1.8	-1.2	-1.3	-1.0	-0.1	-0.2	0.8	1.3	0.8	-1.0	1.1
Chest pain or discomfort	1.2	1.7	3.8	-1.9	-1.6	-1.4	-0.6	-0.3	-1.5	0.6	0.3	-1.2	2.0
Had major operations	0.5	0.6	2.2	-0.7	1.1	1.5	-0.6	0.6	-0.7	-0.5	-0.2	0.1	-0.7
Age at last live birth	0.3	0.4	1.2	-0.6	0.8	0.3	-0.3	-0.7	-0.5	1.1	0.1	-0.1	1.0
Family relationship satisfaction	0.5	0.6	2.6	-0.3	0.2	-0.7	0.0	-1.3	-0.9	0.6	-0.3	1.6	-0.4
Leg pain on walking	0.8	1.0	4.2	0.2	-0.3	-0.2	-0.2	0.3	1.3	2.1	1.7	-0.2	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.2	0.6	1.1	0.4	-0.0	-0.4	0.3	1.6	-0.5	1.8	-1.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.2	1.3	0.5	-0.1	1.3	-1.8	-0.1	-1.1	-0.5	-0.2	-0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.7	1.3	-0.3	-0.8	0.4	1.0	0.1	-1.1	-0.8	-0.7	-0.3
Medication: Aspirin	0.8	1.0	5.1	-1.5	-0.5	1.0	-2.3	0.0	-0.5	-0.6	-0.2	0.8	-0.1
Supplements: Vitamin C	0.3	0.3	1.4	-0.7	1.2	-0.2	0.1	0.5	0.1	-0.4	-0.4	-0.3	-0.7
Knee pain experienced in last month	0.4	0.7	2.5	0.0	1.6	1.1	-0.2	0.2	0.2	0.9	-0.2	-1.3	0.5
Hypertension (Self-reported)	0.5	1.5	3.3	-1.8	-0.2	1.6	-1.8	-1.8	-0.7	0.8	-0.6	-0.7	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.6	4.4	-1.4	0.3	-0.1	-1.9	-2.1	-1.6	-0.8	-1.2	-0.7	-0.9
Illnesses of father: Heart disease	1.0	1.4	5.9	-1.5	-0.4	-0.2	-1.5	-1.0	-2.4	-0.0	-0.7	-1.4	-0.0
Illnesses of siblings: Diabetes	1.0	1.2	6.1	-0.6	-2.5	-0.1	-1.2	0.6	0.3	-1.7	-0.4	-0.3	-1.0
Smoking status: Previous	0.8	1.2	6.5	1.3	-0.3	1.2	0.3	0.2	0.2	0.8	-0.4	2.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	1.1	-0.1	-0.2	-1.1	-0.0	0.0	-0.1	-0.3	-0.7	-0.6	-0.4
Whole body fat-free mass	0.2	1.4	6.7	-0.4	0.7	0.2	0.1	-1.2	-0.6	-2.6	-0.2	-2.1	-0.3
Leg fat-free mass (right)	0.2	1.2	5.3	-0.1	0.8	0.4	0.6	-0.8	0.1	-2.1	1.0	-2.3	0.3
Arm fat percentage (left)	0.2	0.7	3.9	0.6	0.3	0.5	0.5	0.4	0.2	-1.2	2.0	-0.4	0.4
Average weekly red wine intake	1.0	1.5	3.9	1.4	1.6	0.3	0.1	2.0	0.8	-0.0	1.9	0.8	1.2
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	-0.3	0.1	0.3	-0.1	0.6	0.8	0.9	-0.3	-0.6	0.4
Mood swings	0.1	0.2	0.7	-0.3	0.7	-0.6	-0.5	-0.0	0.9	-0.1	0.2	0.4	-0.0
Loneliness, isolation	0.2	0.3	0.8	-0.9	-0.4	-0.8	-0.2	-0.4	0.3	-0.4	0.5	-0.4	-0.4
Long-standing illness, disability or infirmity	0.8	1.3	3.4	-0.2	-0.1	1.6	-0.6	1.2	0.1	1.7	1.4	0.1	1.9
Ever had bowel cancer screening	2.2	2.6	5.6	1.6	-0.1	0.7	2.3	1.1	2.0	2.4	1.5	0.2	2.1
Diabetes diagnosed by doctor	0.6	0.9	3.4	-1.5	-1.9	1.1	-0.5	-1.2	-0.4	-0.2	-0.3	-0.7	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.9	-1.2	0.8	0.6	-0.2	0.3	-0.4	-0.6	-0.7	1.3	-1.4
Friendships satisfaction	0.3	0.4	1.5	-0.1	1.0	-0.1	-0.2	-1.2	-0.8	0.2	-0.2	0.7	-0.2
Qualifications: nursing, teaching	0.6	0.9	2.5	-0.7	0.3	0.1	-0.6	-1.6	-1.0	1.2	0.8	1.1	1.2
Commuting to job workplace: Walk	1.1	1.2	3.5	0.7	1.1	-0.9	-0.8	1.9	1.1	1.6	0.2	1.1	0.1
Eye problems/disorders: Cataract	0.4	0.5	1.6	0.5	-0.3	1.1	-0.4	0.5	-0.3	-1.1	1.3	-0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	0.9	0.4	0.9	-0.9	0.7	-0.9	-0.3	-0.1	0.4	0.5	-0.3
Medication for cholesterol	0.4	0.6	1.8	1.4	-0.1	-0.8	0.2	0.9	-0.4	-0.9	0.3	1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	1.4	0.5	0.7	0.8	0.1	1.0	1.6	1.4	1.3	1.3
Back pain experienced in last month	0.5	0.8	1.9	-1.1	-1.1	-1.4	-0.1	-0.8	-0.4	-0.9	-1.0	-0.8	0.0
Mineral and other dietary supplements	0.3	0.5	1.8	0.4	-1.0	0.6	0.1	0.8	1.3	-0.7	-0.2	-0.4	0.2
Breast cancer (self-reported)	0.4	0.5	1.3	-0.9	0.1	-1.1	-0.9	-0.6	-0.4	-0.6	-0.5	0.3	-0.7
Asthma (self-reported)	0.5	1.1	2.3	-0.7	-1.3	-1.2	-0.6	-1.2	-1.0	1.5	-0.3	1.1	0.9
Osteoporosis (self-reported)	0.5	0.6	1.6	0.3	1.3	1.2	-0.3	-0.5	0.0	1.0	-1.2	0.5	0.3
Osteoarthritis (self-reported)	1.2	1.5	4.4	0.7	1.5	2.0	-0.1	-0.4	-0.2	-0.4	-0.6	2.1	-1.9
Medication: Aspirin	0.6	0.7	3.7	-1.2	0.0	1.2	-1.9	-0.3	-0.4	-0.3	0.2	0.3	0.6
Medication: Gliclazide	1.0	1.1	3.0	-0.9	-1.7	0.5	-0.8	-1.2	-0.6	-1.6	-0.8	-0.6	-1.0
Illnesses of father: None of the above (group 1)	1.3	1.6	5.9	1.3	0.7	0.7	0.5	0.0	2.4	1.0	-0.8	2.3	-0.9
Smoking status: Current	0.8	1.3	3.9	-0.5	-1.8	-1.7	0.2	0.1	2.0	-0.0	-0.3	1.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.4	-0.4	0.3	1.4	-0.8	-1.6	-1.8	-0.4	-0.7	-1.6	0.3
Whole body water mass	0.3	1.5	7.5	-0.5	0.6	0.2	0.1	-1.3	-0.6	-2.7	-0.3	-2.2	-0.4
Leg predicted mass (right)	0.2	1.2	4.9	-0.0	0.8	0.4	0.6	-0.8	0.1	-2.1	0.9	-2.2	0.3
Arm fat mass (left)	0.2	0.9	3.0	0.4	0.5	0.6	0.5	0.3	0.2	-1.7	1.7	-1.2	0.4
Number of self-reported non-cancer illnesses	0.6	1.1	2.8	-1.2	0.4	1.5	-1.2	-0.9	-0.4	1.7	0.3	-0.6	1.2
Average weekly champagne plus white wine intake	0.8	1.2	4.6	-2.2	0.0	0.4	-1.8	-0.1	-1.6	0.2	0.1	-1.0	0.0
Miserableness	0.5	0.8	4.3	0.7	0.6	-0.5	0.3	-0.0	1.5	0.5	0.6	2.1	0.1
Guilty feelings	0.3	0.4	1.4	-0.2	1.2	-1.1	-0.3	-0.5	0.6	-0.3	0.4	0.5	-0.1
Wears glasses or contact lenses	0.8	1.0	2.7	-0.5	1.4	1.1	-0.2	1.6	0.2	1.2	1.0	0.7	-0.8
Ever taken oral contraceptive pill	1.1	1.3	4.9	-0.9	-0.1	0.6	-0.6	-0.4	-1.6	-1.0	-2.2	-0.4	-1.5
Hearing aid user	1.4	1.5	6.1	2.5	-0.3	0.6	0.8	1.5	1.2	-0.5	1.7	1.2	0.2
Mother’s age at death	0.1	0.2	0.5	-0.4	0.5	0.2	0.3	-0.4	-0.6	0.1	0.0	-0.0	-0.7
Financial situation satisfaction	0.5	0.7	2.1	-0.3	-1.3	-1.0	-0.7	-1.4	-0.8	0.3	0.1	0.7	-0.2
Tinnitus: Yes, now most or all of the time	0.9	1.0	3.0	-1.1	-0.9	-1.7	-1.4	-0.2	0.9	0.3	0.2	-1.3	0.6
Commuting to job workplace: Public transport	0.8	1.0	3.3	-1.0	-1.0	-1.8	-0.9	0.1	0.1	0.4	0.4	-0.9	1.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	0.2	0.4	0.8	-0.6	0.5	-0.5	0.9	-0.2	-0.0	0.6
Medication: Blood pressure	0.4	0.8	4.3	-0.1	0.7	1.4	0.2	-0.6	0.2	2.1	-1.0	0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.9	0.7	0.5	-1.2	0.4	0.8	1.4	-0.1	-0.5	0.9	0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.1	-0.3	1.4	1.0	-0.8	-1.2	-1.1	0.4	-0.4	0.5	-0.8
High cholesterol (Self-reported)	0.8	1.4	7.5	-1.3	-2.7	0.0	-0.8	-1.2	-1.4	0.2	-0.6	0.3	0.3
Medication: Bendroflumethiazide	0.4	0.6	1.7	0.1	0.8	0.1	-0.3	-0.8	0.9	1.2	-1.3	0.2	-0.5
Medication: Paracetamol	0.5	0.7	3.4	-0.4	0.7	0.8	0.5	-0.6	1.2	0.1	0.8	-1.9	-0.0
Medication: Lisinopril	0.8	1.1	3.8	-0.6	-1.0	0.4	0.2	0.5	0.5	0.8	1.9	-1.7	1.3
Medication: Atorvastatin	0.8	1.0	3.4	-1.0	-0.6	0.0	-0.6	-1.3	-0.2	-0.2	-1.2	1.2	-1.8
Illnesses of father: High blood pressure	1.3	1.6	4.4	-1.7	0.7	-1.1	-0.3	-1.2	-1.9	-1.4	-0.1	-2.1	0.3
Alcohol drinker status: Never	0.9	1.1	2.5	-1.5	-1.3	-1.3	-0.4	-0.4	0.1	-1.6	-0.3	-1.4	-0.6
Ever smoked	0.9	1.5	9.1	1.3	0.4	-0.3	1.0	0.4	1.1	1.0	-0.1	3.0	-0.9
Basal metabolic rate	0.2	1.4	6.7	-0.4	0.7	0.4	0.1	-1.1	-0.4	-2.6	0.2	-2.1	-0.2
Leg fat percentage (left)	0.2	0.9	2.8	0.6	0.4	1.6	0.0	0.7	0.9	-1.2	1.7	0.3	-0.1
Arm fat-free mass (left)	0.3	1.6	7.8	-0.6	0.7	0.4	-0.0	-1.2	-0.5	-2.8	-0.0	-2.3	-0.4
Number of operations (self-reported)	1.1	1.7	5.7	-1.0	2.4	1.6	-1.2	-1.4	-0.8	0.0	-0.9	1.1	-1.2
Average weekly beer plus cider intake	0.2	0.3	1.6	-0.3	-0.1	-0.6	0.6	-0.6	0.0	-1.2	-0.4	-0.1	-0.8
Irritability	0.6	1.0	4.6	0.3	0.0	-0.3	0.3	1.0	1.3	1.5	0.1	2.2	-0.3
Risk taking	0.4	0.6	2.1	0.7	0.2	0.3	1.0	1.1	1.4	0.2	0.3	0.3	1.0
Ever had prostate specific antigen (PSA) test	2.5	2.9	7.5	2.1	1.4	-0.7	2.2	2.7	2.4	0.7	1.6	-0.6	0.9
Fractured/broken bones in last 5 years	0.7	0.8	2.4	-0.6	0.9	-0.7	-1.6	-0.6	-1.0	-0.5	-1.0	1.1	-0.8
Age started oral contraceptive pill	0.5	0.7	1.7	1.0	-0.2	-1.2	1.3	0.4	0.2	-0.4	1.1	-0.2	0.9
Diastolic blood pressure, automated reading	0.9	2.9	9.1	-1.2	1.0	1.8	-1.8	-3.0	-2.5	-0.1	-2.0	-0.2	-0.5
Ever depressed for a whole week	0.6	0.7	2.1	-0.3	0.7	1.0	-1.1	-1.5	-1.0	-0.3	0.2	0.9	-0.1
Unable to work because of sickness or disability	2.4	3.2	16.5	-0.4	-0.7	0.5	-0.8	0.1	0.2	2.2	4.1	-0.6	2.9
Commuting to job workplace: Cycle	0.5	0.6	3.6	-0.0	0.3	-0.2	-0.5	-0.7	-1.1	0.8	-0.2	1.9	0.0
Myopia	0.5	0.7	2.5	-1.2	-1.1	-0.2	-0.5	-0.5	-1.6	0.2	0.1	-0.9	0.6
Vascular/heart problems diagnosed by doctor	0.8	2.2	7.7	2.6	0.5	-1.0	2.8	2.0	0.9	-0.1	0.6	0.8	-0.4
Cholesterol lowering medication	0.4	0.6	2.0	-0.7	-1.4	-0.8	0.2	-0.8	0.5	1.1	-0.3	0.9	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.3	-1.5	-0.5	0.6	-1.5	-0.4	-1.0	1.3	0.5	-0.4	0.6
Pain experienced in last month	0.2	0.4	1.8	-0.2	0.2	0.5	-0.9	-0.0	-0.3	0.5	1.3	-0.0	0.7
Supplements: Calcium	0.8	0.9	3.5	-0.7	1.2	-1.9	0.3	0.6	0.7	0.8	-0.5	1.0	-0.5
Basal cell carcinoma (self-reported)	0.4	0.5	2.4	0.0	-0.3	1.0	0.0	1.5	0.4	1.0	-0.4	-0.3	-0.5
Heart attack/myocardial infarction (self-reported)	1.5	1.9	3.7	-1.3	-0.1	0.9	-0.7	-1.9	-1.9	-1.7	-1.5	-0.8	-1.7
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.9	0.2	-0.8	-0.9	0.3	0.4	-0.5	-0.6	-0.3	-1.0	-0.8
Heart disease (siblings)	2.0	2.5	6.5	-0.7	-2.0	1.7	-1.5	1.2	-0.7	-1.3	-1.1	2.5	-2.0
Alcohol drinker status: Previous	0.6	0.7	2.3	-0.3	-0.1	-0.8	-0.7	-0.8	-1.5	-0.5	-0.4	-0.7	1.3
Pack years of smoking	0.5	0.7	1.3	1.0	0.1	1.0	1.1	1.1	0.5	0.9	0.8	1.1	0.3
Impedance of whole body	0.4	1.9	5.0	0.4	-1.0	-1.6	-0.8	2.0	0.7	2.2	-0.3	2.2	-0.3
Leg fat mass (left)	0.2	0.9	3.3	0.4	0.7	1.4	-0.1	0.3	0.4	-1.8	1.4	-0.6	-0.1
Arm predicted mass (left)	0.3	1.8	9.8	-0.6	0.5	0.3	0.1	-1.3	-0.5	-3.1	-0.4	-2.1	-0.8