Hub : Genes

RCSD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1340 0.0440 1.5e-03 0.099 NA 0.078 NA 0.088 1.8e-08 NA 5.7e-07 NA 1.2e-07
2 GTEx Breast Mammary Tissue 0.3560 0.0750 2.5e-05 -0.005 NA 0.018 NA 0.002 8.5e-01 NA 3.7e-02 NA 2.4e-01
3 GTEx Esophagus Muscularis 0.2550 0.0630 2.0e-05 0.139 NA 0.156 NA 0.146 8.7e-09 NA 9.5e-10 NA 3.4e-09
4 GTEx Lung 0.1415 0.0452 1.1e-03 0.052 NA 0.072 NA 0.074 7.6e-05 NA 3.4e-06 NA 2.4e-06
5 GTEx Thyroid 0.2340 0.0640 3.8e-04 0.049 NA 0.035 NA 0.042 1.2e-04 NA 1.0e-03 NA 3.6e-04
6 GTEx Whole Blood 0.0890 0.0360 6.7e-03 0.055 NA 0.037 NA 0.035 7.6e-06 NA 2.4e-04 NA 3.2e-04
7 METSIM Adipose 0.0530 0.0203 3.4e-03 0.001 0.019 0.000 0.015 0.002 1.9e-01 5.6e-04 3.4e-01 2.0e-03 1.7e-01
8 NTR Blood 0.0729 0.0170 1.8e-08 0.010 0.028 0.023 0.029 0.028 2.3e-04 2.4e-09 3.9e-08 8.2e-10 1.5e-09
9 ROSMAP Brain Pre-frontal Cortex 0.0858 0.0282 4.4e-04 -0.002 0.024 0.010 0.021 0.002 9.7e-01 3.8e-04 1.7e-02 8.8e-04 1.9e-01
10 YFS Blood 0.1342 0.0200 0.0e+00 0.115 0.119 0.138 0.132 0.132 1.3e-35 1.1e-36 5.7e-43 4.9e-41 8.9e-41

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bipolar Disorder (2018) 0.4 0.6 2.1 -0.6 -1.2 -0.3 -0.4 -1.4 -0.5 0.3 0.1 -0.3 1.4
Bipolar Disorder or Schizophrenia 0.2 0.6 4.1 -0.1 0.5 0.3 -0.3 -0.3 -0.2 -0.4 -1.0 2.0 -0.5
Depressed Affect (Nagel 2018) 0.3 0.6 3.0 -0.2 0.6 -0.5 -0.6 -0.4 1.1 -0.2 0.3 1.7 -0.5
Depression (Nagel 2018) 0.7 1.0 5.2 -0.2 -0.1 -0.4 -0.1 0.6 1.8 0.9 0.5 2.3 -0.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 2.6 -0.3 -0.7 1.6 -0.6 -1.0 0.6 0.0 0.4 -1.2 0.6
Neuroticism (Nagel 2018) 0.5 1.2 5.8 -0.5 0.8 -2.0 -0.3 -0.5 0.4 -0.1 -0.1 2.4 -1.0
Schizophrenia (2018) 0.8 1.7 8.2 0.3 1.6 0.6 -0.1 0.7 -0.0 -0.7 -1.4 2.9 -1.7
Schizophrenia vs Biploar Disorder 3.4 4.5 11.6 1.1 3.3 2.3 0.3 2.2 1.8 2.0 0.9 3.4 -1.7
Worry (Nagel 2018) 0.5 1.0 5.5 -0.4 0.3 -2.3 0.4 -0.3 -0.4 0.5 0.6 1.8 0.2
Alzheimer’s Disease (in mother) 0.6 0.7 3.0 -0.8 0.2 0.0 -1.5 -0.8 -1.7 -0.2 0.4 0.4 0.6
Alzheimer’s Disease (in father) 1.6 1.7 7.2 1.3 1.4 2.7 -0.0 0.8 0.8 0.6 0.5 2.0 -0.7
Alzheimer’s Disease (including proxy) 0.7 1.1 3.8 0.6 0.7 2.0 -0.8 0.5 -0.3 0.5 1.5 1.5 0.6
Crohns Disease (2017) 0.3 0.8 3.6 -0.2 0.3 -0.2 0.8 0.0 0.3 -1.4 -0.4 -0.9 -1.9
Irritable Bowel Disease (IBD) 0.5 1.2 4.5 -0.7 1.0 -0.1 0.0 -0.7 -0.6 -1.4 -1.6 -1.1 -2.1
Ulcerative Colitis (UC) 0.6 1.2 4.2 -0.9 1.2 0.1 -0.5 -0.9 -1.2 -0.7 -2.0 -0.7 -1.4
Major Depression (MDD) 1.1 1.4 3.7 1.0 -0.2 -0.1 0.9 0.7 1.0 1.2 1.7 -1.6 1.9
Reaction Time 0.3 0.6 2.9 -0.3 -0.3 0.6 -1.7 -0.1 -1.2 0.1 0.8 -0.7 0.4
Verbal and Numeric Reasoning (VNR) 0.7 1.8 5.7 -2.2 -0.8 0.8 -2.4 -1.8 -1.1 -0.1 0.1 -1.2 0.2
Breast Cancer 0.6 1.4 4.8 1.8 2.2 1.2 0.8 0.3 1.0 -0.8 -0.5 0.9 -1.1
Ovarian Cancer 0.4 0.5 1.3 0.7 0.8 1.1 -0.5 1.1 -0.2 0.5 0.6 -0.0 0.4
Prostate Cancer 0.5 0.7 2.5 -0.4 0.6 0.3 -0.1 -1.2 -0.0 -1.1 -1.0 0.1 -1.6
Age at First Birth 0.9 1.3 4.5 -1.6 0.4 -1.3 -0.3 -0.8 -1.3 -2.1 0.4 -1.2 0.4
Bipolar Disorder (2011) 0.2 0.2 1.0 0.5 -0.2 -0.4 1.0 -0.3 0.2 0.1 -0.4 0.7 0.3
Body Mass Index (BMI) (2010) 0.3 0.4 1.6 -1.2 -0.1 0.5 -1.3 0.0 0.2 -0.0 -0.1 -0.4 -0.8
Coronary Artery Disease (CAD) 0.4 0.4 1.4 0.3 0.3 -0.5 0.8 -0.4 -0.6 0.0 -1.2 0.7 -0.9
Crohns Disease (2012) 0.4 0.6 2.1 0.8 0.3 -0.3 1.0 -0.1 -0.7 -1.3 0.2 0.5 -1.5
Mean Putamen Volume 0.5 0.6 3.1 -0.2 -0.4 0.7 -0.7 -0.4 0.2 1.0 -0.4 1.8 -0.2
Fasting Glucose 0.7 0.8 2.6 -1.6 -1.0 -0.8 -0.6 -0.4 -0.3 -1.4 0.3 -0.7 -0.7
HbA1C 1.9 2.1 6.1 1.8 0.3 -0.0 1.8 0.4 1.8 2.5 1.0 -0.4 2.0
HDL Cholesterol 0.1 0.2 0.8 0.1 -0.6 -0.9 0.1 -0.0 0.3 -0.2 -0.0 0.2 -0.6
LDL Cholesterol 0.3 0.4 1.1 -0.8 -0.6 0.8 -0.9 -0.3 0.0 0.4 -0.4 0.4 -1.0
Lupus 2.4 3.7 13.5 0.1 0.5 0.6 0.2 1.5 0.7 3.5 2.7 -0.5 3.7
Neuroticism (2016) 0.8 1.2 3.8 0.6 0.6 -0.8 0.2 1.7 1.9 0.2 0.9 1.6 -0.1
Primary Biliary Cirrhosis 0.3 0.4 1.2 0.5 0.6 0.5 0.4 -1.1 0.8 -0.3 0.6 -0.5 0.4
Rheumatoid Arthritis 2.1 2.9 6.5 1.0 -2.5 -0.3 1.0 1.0 1.8 2.0 1.8 1.7 2.5
Schizophrenia (2014) 0.5 1.1 6.9 0.3 1.5 0.5 -0.6 0.2 0.7 0.4 -0.4 2.6 -0.7
Triglycerides 0.9 1.5 3.8 1.1 0.2 1.9 0.3 0.6 0.1 2.0 1.7 -0.1 1.8
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.2 0.7 -0.4 -1.1 0.7 -0.0 0.5 -0.9 0.1 0.0 0.1
Ulcerative Colitis 0.6 0.8 1.8 -0.2 0.6 0.2 0.5 -1.1 -1.2 -1.3 -1.1 -0.4 -1.3
Blood Eosinophil Count 0.2 1.5 7.5 -0.5 -0.9 1.5 0.0 -0.5 -0.2 1.8 -0.5 2.7 -0.2
Blood Platelet Count 0.2 2.6 8.8 -2.1 1.1 -0.4 -3.0 -1.0 -1.9 0.2 0.8 -0.3 2.5
Blood Red Count 0.4 3.8 6.6 -2.2 -1.0 2.0 -2.1 -0.8 -1.3 -2.6 -2.5 -2.0 -2.0
Blood White Count 2.3 16.9 49.3 7.0 3.3 1.9 5.8 4.1 5.9 1.8 1.9 3.4 -0.9
Heel T-Score 0.2 1.4 6.5 0.3 -1.2 2.5 -1.0 -1.1 -1.5 0.8 0.0 -1.0 0.6
BMI 0.2 1.3 3.3 0.1 0.9 1.7 0.2 -0.4 0.3 -1.7 1.8 -1.6 0.2
Height 0.2 3.1 13.7 -0.8 0.9 -1.3 -0.9 -0.4 0.2 -0.6 2.9 -3.7 2.1
Waist Hip Ratio (WHR) 0.6 2.6 8.8 1.2 -0.5 -2.5 1.4 0.3 0.4 1.0 2.2 -0.9 3.0
Systolic Blood Pressure 0.4 2.0 7.1 -0.6 -0.3 1.9 -0.7 -1.8 -1.0 1.9 -2.7 1.1 0.0
Smoking Status 0.9 2.2 7.5 0.3 -1.4 -0.3 -0.6 0.0 1.9 -0.1 -1.3 2.7 -2.5
Allergy or Eczema 0.6 1.6 6.9 -0.3 0.0 -0.6 0.2 -0.3 -0.1 1.9 1.5 1.6 2.6
Cardiovascular Disease 1.2 4.0 9.4 -2.7 -2.6 1.7 -1.8 -3.1 -2.3 -0.5 -1.8 -0.9 -0.3
Hypothyroidism (self reported) 0.5 1.1 6.1 -0.5 -0.8 0.5 -0.4 -0.2 -1.0 -1.0 -0.8 -2.5 -0.7
Respiratory disease 0.9 2.1 7.4 0.4 -0.6 -1.5 -0.1 -0.1 0.6 2.4 1.6 1.4 2.7
Type 2 Diabetes (T2D) (2018) 0.7 1.2 3.3 -1.8 -1.8 0.9 -1.1 -1.6 -0.7 -0.6 -0.5 -0.6 0.2
Lung FEV1/FVC ratio 0.9 4.3 13.4 -2.2 -0.5 1.1 -2.5 -1.8 -3.7 -0.9 -1.6 -3.2 -0.7
Lung FVC 0.4 1.9 10.5 -0.2 0.5 -0.0 1.1 -0.4 -0.9 -1.4 -3.2 0.1 -2.1
Neuroticism 0.6 1.5 9.3 0.4 1.1 -1.6 0.5 0.5 0.8 0.6 0.3 3.0 -0.7
Chronotype (morning person) 1.2 2.8 7.4 2.7 1.0 1.6 2.6 1.7 1.2 1.7 1.1 1.3 -0.1
Hair Pigment 0.0 1.3 6.0 -0.2 0.4 1.9 0.1 1.1 -0.6 -1.0 0.7 -2.4 0.2
Tanning 0.0 0.4 1.0 -0.2 0.1 0.2 0.5 -1.0 -0.3 0.9 -1.0 -0.4 0.4
Hand grip strength (left) 0.2 0.6 1.3 1.1 0.9 -0.4 1.1 -0.7 0.4 -0.6 -0.5 -1.0 0.2
Number of treatments/medications taken 0.6 1.1 2.4 -1.5 -0.9 1.3 -0.9 -1.0 -0.7 1.4 0.9 -0.1 0.6
Average weekly spirits intake 0.3 0.3 0.7 -0.8 0.0 -0.7 0.7 -0.6 -0.1 -0.6 -0.5 0.6 -0.7
Sensitivity / hurt feelings 0.3 0.5 2.1 0.0 -0.8 -1.4 1.0 0.9 -0.4 0.2 0.2 0.2 -0.6
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.3 -1.1 -0.8 -1.1 0.5 -0.8 0.4 0.3 -0.7 0.5 -0.3
Hearing difficulty/problems: Yes 0.6 0.9 2.4 -0.4 1.4 0.2 -1.1 -0.6 -0.7 -0.4 -1.3 0.4 -1.6
Relative age of first facial hair 0.4 0.9 2.6 0.4 -0.5 -0.2 0.2 -0.8 -1.6 0.7 1.2 -0.8 1.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 5.0 -0.8 0.3 1.5 -0.6 0.7 1.2 1.1 1.5 -1.0 2.2
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.5 0.4 0.4 0.1 0.6 0.6 1.2 0.4 0.3 1.1 -0.7
Ever had hysterectomy (womb removed) 0.6 0.7 3.7 -1.5 -0.7 0.1 -1.9 -0.4 0.0 -0.1 0.2 -0.4 0.2
Systolic blood pressure, automated reading 0.4 1.2 4.8 -0.4 1.1 2.2 -0.8 -1.1 -0.6 0.2 -1.6 0.3 -0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.4 -0.5 -1.2 0.1 -0.1 -0.8 0.4 0.1 -0.2 -0.5 -0.2
Angina 2.7 3.5 9.1 -2.7 -0.2 0.8 -3.0 -2.3 -3.0 -0.9 -1.0 -1.6 -0.1
Medication for hormone replacement therapy 0.6 0.7 3.1 -1.3 -0.8 0.2 0.3 -0.1 0.8 -0.3 0.8 -1.8 0.2
Vitamin and mineral supplements 0.3 0.4 0.9 0.8 -0.6 0.9 0.0 0.9 0.1 0.2 0.6 -0.3 0.7
Supplements: Zinc 1.0 1.0 3.5 0.4 1.5 0.4 0.0 1.9 1.7 1.1 0.2 0.3 -0.2
Medication: Co-codamol 1.8 2.1 9.1 -1.2 -3.0 -1.1 -0.6 0.3 -0.7 -1.2 0.4 -2.3 1.1
Medication: Metformin 1.2 1.8 8.0 -1.4 -2.8 -0.5 -0.0 -1.0 -0.9 -1.5 -1.6 -0.5 -0.9
Diabetes (father) 1.8 2.2 13.1 -1.3 -1.7 -1.7 0.0 -0.0 0.0 -0.4 0.1 -3.6 1.2
Diabetes (mother) 0.4 0.5 1.7 0.4 -1.3 -0.2 0.3 -0.6 1.2 0.0 0.4 -0.9 0.4
Severe depression (siblings) 0.3 0.3 1.1 0.3 -0.2 -0.6 -0.3 -0.5 0.1 0.7 0.7 0.3 1.0
Pack years adult smoking proportion 0.6 0.8 1.6 1.0 -0.4 1.0 1.0 1.3 0.6 1.0 1.1 0.8 0.5
Impedance of leg (right) 0.3 1.6 4.8 -0.1 -1.3 -1.0 -1.4 1.2 0.3 1.6 -1.4 2.2 -0.8
Leg fat-free mass (left) 0.2 1.2 5.0 -0.2 0.6 0.4 0.3 -0.8 -0.2 -2.2 0.8 -2.1 0.2
Trunk fat percentage 0.3 1.1 5.2 0.9 0.5 0.8 0.3 1.3 1.1 -1.0 2.3 -0.1 0.3
Hand grip strength (right) 0.5 1.3 3.5 0.8 0.9 -0.0 0.4 -1.1 -0.3 -1.9 -1.6 1.1 -1.8
Townsend deprivation index at recruitment 0.7 1.0 4.9 -0.6 -2.2 -1.4 0.3 0.1 0.5 -1.4 0.4 -0.6 -0.2
Current tobacco smoking 1.0 1.6 5.1 -0.7 -2.3 -1.9 -0.1 0.1 1.7 -0.2 -0.8 1.1 -1.4
Average weekly fortified wine intake 0.4 0.5 1.3 -0.8 0.5 1.1 -0.0 0.9 0.1 0.5 -0.8 0.6 -1.1
Maternal smoking around birth 0.2 0.3 1.0 -0.2 -1.0 0.2 -0.0 -0.6 -0.3 0.5 0.8 0.4 0.2
Fed-up feelings 0.5 0.9 3.0 -1.7 -1.2 -1.3 -1.1 -1.0 0.3 -0.4 0.3 -0.3 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 3.2 -0.3 -0.7 -1.8 -0.2 0.3 1.5 0.2 -0.4 1.4 -0.1
Relative age voice broke 3.2 4.8 10.9 3.0 0.7 -0.7 3.0 2.5 2.0 2.0 3.3 0.1 2.1
Taking other prescription medications 0.8 1.2 3.7 -0.5 0.8 0.8 -0.7 -0.9 -1.5 1.7 0.3 0.3 1.9
Age when periods started (menarche) 0.2 0.4 1.6 -0.6 0.8 -0.4 -0.3 1.3 0.2 0.4 0.8 -0.4 0.3
Bilateral oophorectomy (both ovaries removed) 1.6 1.9 8.9 -2.3 0.4 0.3 -3.0 -0.8 -1.2 -0.4 0.1 -1.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.1 0.4 -0.3 -0.0 -0.2 -0.2 0.4 0.3 -0.2 0.2 -0.1
Tinnitus: Yes, but not now, but have in the past 0.7 0.7 3.1 -0.1 1.2 0.4 -1.2 -0.7 -1.8 -0.1 0.4 0.5 0.4
Qualifications: CSEs or equivalent 0.7 1.0 6.3 0.2 -2.5 -0.3 -0.5 -0.9 1.2 -0.6 0.4 -0.7 0.1
Serious illness, injury or assault to yourself 0.7 0.8 4.6 -0.4 -0.5 0.4 0.7 -0.7 0.3 1.0 1.0 2.1 -0.0
High blood pressure 0.5 1.5 4.0 -1.9 -0.2 1.2 -2.0 -1.7 -0.6 1.1 -0.5 -0.5 0.8
Hayfever, allergic rhinitis or eczema 0.9 2.0 8.6 -0.2 0.3 -1.0 0.2 -0.3 0.3 2.2 1.9 1.1 2.9
Multivitamins +/- minerals 0.7 0.9 2.7 -1.1 0.0 -0.5 -0.6 -1.6 -0.7 0.3 -1.1 0.5 -1.5
Stomach or abdominal pain in last month 0.4 0.5 2.1 -0.5 -1.5 0.4 -1.1 0.2 -0.4 0.4 0.6 0.6 0.6
Supplements: Glucosamine 0.5 0.6 4.6 -0.3 0.4 0.0 0.3 -1.0 -2.1 0.1 -0.1 0.2 -0.6
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.0 -0.5 -1.2 1.4 -1.3 2.0 1.3 0.2 1.3 1.1 -0.3
Medication: Atenolol 0.7 0.9 2.3 0.5 0.3 0.9 -0.4 -1.2 -1.5 0.7 0.9 -0.9 1.4
Medication: Levothyroxine sodium 0.4 0.7 1.9 0.8 -0.3 1.3 0.7 0.9 -0.2 -0.5 -0.8 -0.9 -1.4
Sitting height 0.3 2.0 4.2 -2.0 -0.8 -0.7 -1.6 1.0 0.4 -2.0 -1.3 -1.7 -1.5
Chronic bronchitis/emphysema (father) 1.0 1.2 4.1 -0.6 0.6 0.1 -0.7 -2.0 -2.0 -0.9 -0.5 0.8 -0.6
High blood pressure (mother) 1.0 1.4 6.8 -1.3 0.1 -0.3 -0.7 -2.6 -0.9 -1.8 -0.7 -0.4 -0.8
Body mass index (BMI) 0.2 1.1 3.0 0.3 0.6 1.7 0.5 -0.3 0.2 -1.7 1.7 -0.8 0.3
Impedance of leg (left) 0.3 1.5 4.9 -0.0 -0.8 -0.8 -1.2 1.4 0.6 1.6 -1.2 2.2 -0.7
Leg predicted mass (left) 0.2 1.2 5.0 -0.2 0.6 0.3 0.2 -0.8 -0.2 -2.2 0.8 -2.2 0.2
Trunk fat mass 0.3 1.1 4.9 0.7 0.6 0.7 0.3 0.8 0.8 -1.6 2.2 -0.9 0.5
Waist circumference 0.3 1.2 5.2 0.1 -0.1 0.3 -0.0 -0.2 0.5 -1.3 2.3 -1.4 1.6
Number of incorrect matches in round 0.6 0.9 3.7 -0.3 -0.7 1.1 -0.5 -0.6 -0.3 -0.1 -1.9 0.5 -1.7
Past tobacco smoking 0.8 1.4 9.3 -1.1 0.2 -0.4 -0.3 -0.2 -0.8 -1.0 0.5 -3.0 1.1
Alcohol usually taken with meals 0.5 0.8 3.3 0.9 0.7 0.5 -0.3 1.8 0.3 0.8 0.8 0.6 1.0
Nervous feelings 0.5 1.0 3.0 0.4 1.7 -1.5 1.4 0.2 -0.2 1.3 0.8 0.5 0.2
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.7 -1.5 -1.0 -1.9 -0.0 -0.7 0.5 0.7 0.5 0.7 0.1
Hearing difficulty/problems with background noise 0.5 0.8 3.5 -0.2 1.9 0.1 -0.4 -0.7 -1.9 -0.4 -0.0 -0.2 0.4
Hair/balding pattern: Pattern 2 1.0 1.3 6.0 -1.0 2.5 0.1 -0.9 -0.9 0.2 -0.7 0.4 -1.8 0.7
Had menopause 0.6 0.7 2.3 0.1 -1.4 -1.0 0.4 0.7 0.8 0.0 0.8 1.5 -0.5
Had other major operations 0.3 0.3 0.8 -0.6 0.6 0.4 0.1 -0.6 -0.1 0.9 0.6 -0.8 0.5
Forced vital capacity (FVC) 0.2 0.8 2.2 -0.2 -0.1 -1.4 0.1 -1.0 -0.2 -0.9 -1.5 -0.9 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.5 1.2 1.2 0.7 0.8 -0.2 0.8 0.4 0.3 0.5 0.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.8 -1.0 -1.2 -0.5 -0.9 -0.9 -0.7 0.3 1.7 -0.1 1.1
Qualifications: None of the above 0.3 0.6 2.1 -0.1 -1.1 -0.0 0.1 0.3 -0.9 -0.9 -0.9 0.1 -1.4
Financial difficulties in last 2 years 0.5 0.7 2.2 -0.8 -1.5 -0.3 0.4 -0.3 0.8 1.4 0.1 0.9 -0.0
Mouth/teeth dental problems 0.2 0.3 1.9 0.4 0.3 -0.0 1.4 0.2 -0.5 0.3 -0.4 -0.5 0.4
Heart attack 1.5 1.9 3.9 -1.3 -0.3 1.0 -0.6 -1.7 -1.6 -1.7 -1.7 -0.5 -2.0
Allergy 0.9 2.0 6.4 -0.2 0.6 1.1 -0.1 -0.5 -0.8 -2.3 -2.1 -1.3 -2.5
Pain all over the body in last month 4.6 5.0 13.8 -2.8 -1.7 -0.4 -3.7 -1.7 -3.1 -1.4 0.2 -3.0 1.0
Diabetes (self-reported) 0.3 0.5 2.1 -0.5 -1.4 1.3 0.1 -0.7 -0.5 0.2 -0.5 -0.1 0.1
Hayfever/allergic rhinitis (self-reported) 2.1 2.8 7.8 1.6 1.8 0.1 1.2 1.9 1.6 2.1 1.5 2.8 0.4
Medication: Ramipril 0.3 0.4 1.3 -0.2 -0.4 0.1 -0.3 -1.0 -0.1 -0.3 -1.1 -0.3 -0.9
Medication: Simvastatin 0.9 1.4 4.0 -1.0 -1.6 0.6 -1.4 -1.6 -2.0 0.5 -0.1 0.9 0.6
Fluid intelligence score 0.7 1.4 3.6 -1.5 -0.4 0.4 -1.6 -1.2 -0.9 0.5 0.9 -1.9 1.4
Illnesses of siblings 1.2 1.7 3.9 2.0 1.9 0.5 1.3 -0.5 0.8 1.6 1.1 -1.1 1.1
Neuroticism score 0.5 1.0 3.5 0.1 0.6 -1.9 0.4 0.2 0.5 0.7 1.1 1.9 0.3
Weight 0.2 1.0 4.3 0.0 0.6 0.9 0.1 -0.3 0.3 -2.1 1.5 -1.5 0.3
Impedance of arm (right) 0.4 1.7 6.3 0.6 -1.0 -1.6 -0.2 1.4 0.8 2.5 0.6 1.8 0.4
Arm fat percentage (right) 0.2 0.7 3.9 0.5 0.4 0.7 0.4 0.2 0.1 -1.1 2.0 -0.4 0.4
Trunk fat-free mass 0.3 1.8 7.9 -0.8 0.6 0.1 -0.2 -1.5 -0.9 -2.8 -0.8 -2.2 -0.6
Hip circumference 0.3 1.1 3.1 -1.1 0.1 1.4 -0.9 -0.3 0.2 -1.8 0.9 -1.6 0.0
Time employed in main current job 1.1 1.3 2.8 -1.7 -0.6 0.1 -1.1 -1.1 -1.3 -1.6 0.8 -0.8 1.3
Alcohol intake versus 10 years previously 0.6 0.8 2.2 -0.3 -0.7 -0.1 -1.1 0.8 1.0 0.7 1.0 -1.1 1.5
Father’s age at death 0.3 0.5 1.6 -0.4 -1.3 -0.5 0.1 0.9 0.8 -0.3 -0.0 0.6 -0.8
Worrier / anxious feelings 0.6 1.2 4.5 0.2 -0.0 -1.0 0.8 1.1 1.0 1.0 2.1 1.2 1.2
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 4.7 -0.0 -0.0 -0.1 0.8 -0.1 0.4 2.2 1.0 1.6 1.0
Falls in the last year 0.4 0.5 2.9 -0.4 0.4 -0.2 -0.4 -1.7 -0.8 -0.6 -0.5 0.1 -0.4
Hair/balding pattern: Pattern 3 0.6 0.9 3.8 -0.2 -1.8 -0.1 -1.0 -0.3 -0.4 -2.0 0.3 0.1 -0.2
Number of live births 1.2 1.7 4.6 -0.9 0.8 1.3 -1.4 -0.2 -1.5 -0.2 -2.1 0.9 -2.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 2.8 -0.4 -0.0 -1.0 -0.2 -1.2 -0.7 -1.2 -1.6 -1.7 -0.8
Pulse rate 0.5 0.9 3.5 -0.1 -0.1 -1.9 1.5 -0.9 0.3 -0.3 -0.7 -1.1 0.6
Happiness 0.7 0.8 3.5 -0.5 -0.4 -0.7 -1.0 -0.9 -0.8 -0.7 -0.6 0.6 -1.9
Noisy workplace 0.7 0.9 4.6 -0.0 -2.1 -0.0 -0.4 -1.1 1.3 1.1 -0.1 0.1 0.4
Qualifications: A levels/AS levels or equivalent 0.8 1.9 9.4 0.9 0.2 -1.3 1.0 0.8 0.5 1.2 1.7 -0.6 3.1
Serious illness, injury or assault of a close relative in last 2 years 1.0 1.2 2.6 -0.9 0.9 1.3 -0.7 -0.5 -1.4 -0.7 -1.6 1.1 -1.4
Mouth/teeth dental problems: Dentures 0.5 0.9 1.8 0.3 -1.1 1.1 -1.0 0.4 1.3 -0.8 1.1 1.1 -0.2
Asthma 0.7 1.3 3.5 -0.8 -1.9 -1.3 -0.3 -1.4 -0.8 1.6 0.0 1.0 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 2.2 -0.2 1.1 1.5 0.3 -0.6 0.4 0.3 0.0 -0.2 -0.5
Medication: Cholesterol lowering 1.4 2.2 6.6 -1.7 -1.8 0.9 -2.2 -1.3 -2.6 -0.7 -0.9 0.7 -0.4
Depression (self-reported) 0.9 1.1 4.7 -0.8 -2.0 -2.2 0.3 -0.9 -0.3 -0.6 0.6 -0.1 0.4
Medication: Lansoprazole 0.5 0.6 1.8 1.3 -0.3 0.9 0.4 -1.4 -0.2 0.8 0.2 0.4 0.8
Prospective memory result 0.8 0.9 4.2 -2.0 -0.3 -0.5 -1.7 -0.5 -0.7 0.3 -0.8 0.1 -0.6
Lung cancer (father) 1.4 1.6 4.1 -0.4 -1.8 -0.7 -1.0 -0.1 0.1 0.8 1.7 -1.9 2.0
Illnesses of mother 0.2 0.3 1.1 0.2 -0.5 -0.0 0.3 0.8 1.0 0.0 -0.8 -0.4 -0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 3.2 -1.0 0.2 -0.7 -1.1 -1.4 -0.8 -1.0 -1.2 -1.8 -0.4
Pulse wave Arterial Stiffness index 1.0 1.2 4.7 -1.2 -1.5 -1.2 -0.5 -1.3 0.6 -0.1 -0.1 -2.2 0.0
Impedance of arm (left) 0.4 1.7 4.7 0.4 -1.1 -2.0 -0.2 1.9 0.8 2.2 0.8 1.5 0.5
Arm fat mass (right) 0.2 0.9 2.9 0.4 0.3 1.1 0.5 0.1 0.1 -1.6 1.7 -1.0 0.3
Trunk predicted mass 0.3 1.8 7.6 -0.9 0.5 0.1 -0.2 -1.5 -0.9 -2.8 -0.8 -2.3 -0.5
Standing height 0.1 0.7 2.5 -0.4 0.2 -1.4 -0.8 0.2 0.3 -1.1 -0.5 -1.6 -0.1
Length of working week for main job 0.5 0.6 2.2 0.6 0.3 -1.0 1.1 -0.2 1.5 0.7 0.2 -0.2 0.4
Exposure to tobacco smoke at home 0.9 1.0 2.6 -0.3 1.3 1.0 0.0 0.1 -1.0 0.0 -1.4 1.3 -1.6
Breastfed as a baby 1.0 1.2 5.5 -2.3 1.1 0.7 -0.8 -0.4 -0.7 -0.5 -0.4 -1.8 0.3
Tense / ‘highly strung’ 0.3 0.5 1.3 -0.6 0.4 -1.1 0.1 0.1 -0.3 1.1 0.2 0.6 1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.8 2.7 -0.8 -0.4 -1.5 0.8 -0.8 0.3 1.1 -0.3 1.6 0.2
Hair/balding pattern: Pattern 4 0.3 0.7 2.9 -0.9 1.3 -0.3 -0.2 0.9 -0.0 0.2 0.7 -0.8 1.7
Birth weight of first child 0.3 0.6 1.8 0.8 -0.5 0.7 0.1 0.5 0.6 -1.2 1.3 0.1 0.7
Peak expiratory flow (PEF) 0.3 0.6 2.2 -0.1 0.5 1.0 0.2 -0.6 -1.0 -0.6 -1.5 -1.1 -0.3
Pulse wave reflection index 2.2 2.7 7.5 -2.7 -2.3 -0.8 -1.6 -1.4 -1.0 -0.6 0.2 -2.7 0.4
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.6 0.1 -1.2 -0.4 0.8 -0.6 -0.6 -0.6 0.2 0.3 -0.7
Loud music exposure frequency 3.2 3.5 11.6 -1.1 -0.9 -0.9 -0.2 -1.5 -0.7 -2.5 -3.4 1.4 -3.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 2.9 0.7 0.7 -0.8 -0.0 0.3 0.9 0.6 0.4 -0.6 1.7
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 1.9 -1.4 0.2 -0.4 -1.3 -0.2 0.0 -0.4 -0.7 -0.1 -0.6
Blood clot in the leg (DVT) 0.4 0.5 1.6 0.3 -1.3 -1.1 0.4 0.6 -0.1 -0.4 0.0 -1.1 -0.8
Medication: Paracetamol 0.4 0.7 3.9 -1.0 0.4 0.8 0.0 -0.9 0.3 -0.1 0.1 -2.0 -0.3
Headache pain in last month 0.8 1.3 6.3 0.8 -0.9 0.8 0.8 1.1 -0.0 2.5 0.0 -0.2 1.6
Medication for cholesterol, blood pressure or diabetes 1.5 2.5 8.9 1.8 3.0 -0.3 2.2 0.3 2.4 1.0 0.4 0.4 -0.8
Glaucoma (self-reported) 0.6 0.7 3.4 -0.5 0.2 0.2 -1.0 0.5 -0.7 1.1 0.4 -0.6 1.9
Gout (self-reported) 0.6 0.9 4.2 0.2 0.8 1.4 -1.1 -2.0 -0.3 0.5 -0.1 0.2 0.6
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 4.2 0.1 -0.6 0.5 0.6 0.5 -0.3 0.0 -0.3 -2.0 -0.2
Medication: Amlodipine 0.8 1.1 1.8 -1.1 -1.2 0.7 -1.3 -1.4 -0.9 -1.0 -1.2 -0.6 -0.3
Medication: Ventolin 100micrograms inhaler 0.9 1.2 4.6 0.7 -1.4 -1.3 2.2 0.5 1.2 -0.9 -0.5 0.2 -0.8
Birth weight 0.5 1.1 3.2 -0.4 -1.8 -0.2 -1.5 -0.4 -0.9 0.3 1.4 -0.5 1.4
Chronic bronchitis/emphysema (mother) 0.5 0.5 1.9 -1.1 0.2 -0.0 -0.6 -0.4 -1.3 1.4 -0.1 0.2 -0.3
High blood pressure (siblings) 0.7 1.1 3.0 -1.5 -0.7 -0.6 -1.0 0.9 1.0 -0.2 1.1 -0.4 1.7
Forced vital capacity (FVC), Best measure 0.3 1.0 3.0 -0.8 0.2 -1.0 -0.9 -1.7 -0.9 -0.7 -1.2 -1.2 0.0
Body fat percentage 0.2 0.8 3.8 0.7 0.5 0.8 0.2 0.9 0.9 -1.1 2.0 -0.0 0.1
Leg fat percentage (right) 0.2 0.7 2.1 0.4 0.0 1.3 -0.2 0.6 0.5 -1.3 1.4 0.3 -0.3
Arm fat-free mass (right) 0.4 1.9 11.5 -0.5 0.7 0.2 -0.0 -1.1 -0.5 -3.4 -0.5 -2.1 -0.8
Exposure to tobacco smoke outside home 0.7 0.9 4.2 -0.2 2.1 1.1 -0.2 -1.8 -0.7 0.3 -0.0 -0.1 0.2
Comparative body size at age 10 0.5 1.3 4.0 0.8 -0.7 -0.6 0.4 -0.7 -0.1 -1.4 -1.0 1.9 -2.0
Number of full brothers 1.8 2.2 6.9 -2.3 -2.6 -0.0 -0.8 -1.5 0.0 -2.1 -0.5 -1.5 -0.6
Worry too long after embarrassment 0.3 0.5 2.1 -0.4 0.5 -0.2 -0.0 -0.4 -0.0 -0.6 -0.7 1.5 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.3 0.6 -0.0 -1.2 0.9 1.3 0.2 0.9 1.8 1.1 0.7
Wheeze or whistling in the chest in last year 0.9 1.5 5.1 0.2 -2.3 -0.4 0.6 1.0 0.3 1.7 1.7 0.9 1.5
Number of children fathered 0.6 0.6 1.8 0.6 -0.7 0.8 0.6 0.1 1.3 1.2 0.3 0.7 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.8 1.0 0.3 -0.1 1.1 -0.2 1.0 1.3 0.3 0.7 1.2
Age at first live birth 0.7 1.2 5.5 0.1 0.1 -0.1 0.7 -0.7 -0.3 0.5 1.7 -1.5 2.3
Pulse wave peak to peak time 0.8 0.9 3.6 0.9 1.4 0.9 0.2 1.2 -0.7 -0.1 0.1 1.9 -0.0
Health satisfaction 1.5 2.0 6.2 0.2 -0.9 -0.9 1.3 -0.3 1.5 2.5 1.9 0.3 2.0
Shortness of breath walking on level ground 0.5 0.7 2.2 -1.1 -0.8 -0.5 -1.5 -1.3 0.1 0.4 -0.4 0.3 0.2
Qualifications: College or University degree 0.1 0.5 2.6 0.2 0.1 0.4 0.5 -0.5 -0.1 -0.4 0.7 -0.8 1.6
Eye problems/disorders: None of the above 0.5 0.5 1.8 -0.5 1.3 -0.5 -0.3 -1.3 -0.4 -0.2 -1.0 -0.1 -0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 2.2 -1.0 -1.5 -0.7 -1.4 -0.6 -0.0 -0.5 0.3 -0.6 -0.4
Emphysema/chronic bronchitis 1.6 1.8 6.5 0.5 0.1 1.8 -0.8 2.5 1.3 0.8 1.7 -0.3 1.4
Medication for pain relief, constipation, heartburn 0.4 0.6 2.6 1.4 -0.4 -0.8 0.5 1.6 0.1 0.4 -0.4 0.5 -0.1
Neck or shoulder pain in last month 1.2 1.8 3.6 1.6 1.6 0.2 1.0 1.5 1.9 1.8 1.2 0.6 0.7
Medication: Blood pressure 1.0 1.7 4.9 -1.4 -2.1 0.8 -2.2 -0.2 -1.4 0.2 0.1 -1.2 1.3
Angina (self-reported) 2.2 2.8 7.5 -2.4 -0.2 1.1 -2.6 -2.1 -2.7 -0.5 -0.7 -1.3 0.2
Migraine (self-reported) 0.5 0.6 3.3 -0.4 -0.6 0.4 0.3 1.0 -0.8 0.1 -0.2 -1.8 0.6
Medication: Ibuprofen 0.3 0.3 1.9 -0.3 0.6 1.4 -0.1 -0.2 0.8 0.3 -0.1 0.2 -0.4
Medication: Allopurinol 0.4 0.6 2.0 0.4 0.7 0.9 -0.2 -1.4 0.3 1.2 0.1 -0.1 0.8
Medication: Omeprazole 0.7 0.8 1.8 -1.1 -0.3 0.9 -1.1 -0.3 -0.7 1.1 0.8 -0.8 1.3
Medication: Seretide 50 evohaler 1.0 1.2 8.3 -0.0 -1.2 -2.9 0.4 0.3 -0.4 -0.8 -0.7 -0.8 0.0
Mean time to correctly identify matches 0.3 0.7 2.3 -0.4 -0.6 0.2 -1.4 -0.7 -1.5 -0.3 0.7 -0.7 0.3
Heart disease (mother) 0.5 0.6 1.9 0.6 0.6 -0.4 -0.1 0.5 -1.3 -0.6 -0.3 1.4 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 9.2 -1.2 1.2 1.5 -1.8 -1.4 -1.6 0.1 -0.8 3.0 -1.5
Whole body fat mass 0.2 0.9 3.2 0.7 0.7 1.0 0.4 0.6 0.8 -1.6 1.8 -0.7 0.1
Leg fat mass (right) 0.2 0.8 3.9 0.3 0.4 1.3 -0.3 0.1 0.2 -2.0 1.2 -0.6 -0.2
Arm predicted mass (right) 0.3 1.7 9.7 -0.4 0.7 0.3 -0.1 -0.8 -0.5 -3.1 -0.4 -2.1 -0.7
Pulse rate, automated reading 0.5 1.5 2.8 -0.5 -1.4 -1.6 1.5 -1.4 -0.2 0.3 0.7 -1.7 1.6
Alcohol intake frequency. 0.5 1.1 3.5 -0.2 -1.0 -0.7 -0.6 -0.2 -1.5 -1.6 -0.6 -1.9 0.7
Comparative height size at age 10 0.3 1.7 5.6 -0.7 -0.8 -2.4 -1.0 -1.1 -1.5 -1.2 -1.6 -1.4 -0.2
Number of full sisters 0.3 0.3 0.8 0.5 0.2 -0.3 0.6 0.8 0.6 0.9 0.1 -0.4 0.8
Suffer from ‘nerves’ 0.7 1.0 4.1 -0.5 1.1 -1.7 0.4 0.7 0.1 0.6 0.1 2.0 -1.0
Overall health rating 0.5 1.0 1.8 -1.2 -1.3 -1.0 -0.1 -0.2 0.8 1.3 0.8 -1.0 1.1
Chest pain or discomfort 1.2 1.7 3.8 -1.9 -1.6 -1.4 -0.6 -0.3 -1.5 0.6 0.3 -1.2 2.0
Had major operations 0.5 0.6 2.2 -0.7 1.1 1.5 -0.6 0.6 -0.7 -0.5 -0.2 0.1 -0.7
Age at last live birth 0.3 0.4 1.2 -0.6 0.8 0.3 -0.3 -0.7 -0.5 1.1 0.1 -0.1 1.0
Family relationship satisfaction 0.5 0.6 2.6 -0.3 0.2 -0.7 0.0 -1.3 -0.9 0.6 -0.3 1.6 -0.4
Leg pain on walking 0.8 1.0 4.2 0.2 -0.3 -0.2 -0.2 0.3 1.3 2.1 1.7 -0.2 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.2 0.6 1.1 0.4 -0.0 -0.4 0.3 1.6 -0.5 1.8 -1.3
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.2 1.3 0.5 -0.1 1.3 -1.8 -0.1 -1.1 -0.5 -0.2 -0.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.7 1.3 -0.3 -0.8 0.4 1.0 0.1 -1.1 -0.8 -0.7 -0.3
Medication: Aspirin 0.8 1.0 5.1 -1.5 -0.5 1.0 -2.3 0.0 -0.5 -0.6 -0.2 0.8 -0.1
Supplements: Vitamin C 0.3 0.3 1.4 -0.7 1.2 -0.2 0.1 0.5 0.1 -0.4 -0.4 -0.3 -0.7
Knee pain experienced in last month 0.4 0.7 2.5 0.0 1.6 1.1 -0.2 0.2 0.2 0.9 -0.2 -1.3 0.5
Hypertension (Self-reported) 0.5 1.5 3.3 -1.8 -0.2 1.6 -1.8 -1.8 -0.7 0.8 -0.6 -0.7 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.6 4.4 -1.4 0.3 -0.1 -1.9 -2.1 -1.6 -0.8 -1.2 -0.7 -0.9
Illnesses of father: Heart disease 1.0 1.4 5.9 -1.5 -0.4 -0.2 -1.5 -1.0 -2.4 -0.0 -0.7 -1.4 -0.0
Illnesses of siblings: Diabetes 1.0 1.2 6.1 -0.6 -2.5 -0.1 -1.2 0.6 0.3 -1.7 -0.4 -0.3 -1.0
Smoking status: Previous 0.8 1.2 6.5 1.3 -0.3 1.2 0.3 0.2 0.2 0.8 -0.4 2.5 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 1.1 -0.1 -0.2 -1.1 -0.0 0.0 -0.1 -0.3 -0.7 -0.6 -0.4
Whole body fat-free mass 0.2 1.4 6.7 -0.4 0.7 0.2 0.1 -1.2 -0.6 -2.6 -0.2 -2.1 -0.3
Leg fat-free mass (right) 0.2 1.2 5.3 -0.1 0.8 0.4 0.6 -0.8 0.1 -2.1 1.0 -2.3 0.3
Arm fat percentage (left) 0.2 0.7 3.9 0.6 0.3 0.5 0.5 0.4 0.2 -1.2 2.0 -0.4 0.4
Average weekly red wine intake 1.0 1.5 3.9 1.4 1.6 0.3 0.1 2.0 0.8 -0.0 1.9 0.8 1.2
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.8 -0.3 0.1 0.3 -0.1 0.6 0.8 0.9 -0.3 -0.6 0.4
Mood swings 0.1 0.2 0.7 -0.3 0.7 -0.6 -0.5 -0.0 0.9 -0.1 0.2 0.4 -0.0
Loneliness, isolation 0.2 0.3 0.8 -0.9 -0.4 -0.8 -0.2 -0.4 0.3 -0.4 0.5 -0.4 -0.4
Long-standing illness, disability or infirmity 0.8 1.3 3.4 -0.2 -0.1 1.6 -0.6 1.2 0.1 1.7 1.4 0.1 1.9
Ever had bowel cancer screening 2.2 2.6 5.6 1.6 -0.1 0.7 2.3 1.1 2.0 2.4 1.5 0.2 2.1
Diabetes diagnosed by doctor 0.6 0.9 3.4 -1.5 -1.9 1.1 -0.5 -1.2 -0.4 -0.2 -0.3 -0.7 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.9 -1.2 0.8 0.6 -0.2 0.3 -0.4 -0.6 -0.7 1.3 -1.4
Friendships satisfaction 0.3 0.4 1.5 -0.1 1.0 -0.1 -0.2 -1.2 -0.8 0.2 -0.2 0.7 -0.2
Qualifications: nursing, teaching 0.6 0.9 2.5 -0.7 0.3 0.1 -0.6 -1.6 -1.0 1.2 0.8 1.1 1.2
Commuting to job workplace: Walk 1.1 1.2 3.5 0.7 1.1 -0.9 -0.8 1.9 1.1 1.6 0.2 1.1 0.1
Eye problems/disorders: Cataract 0.4 0.5 1.6 0.5 -0.3 1.1 -0.4 0.5 -0.3 -1.1 1.3 -0.5 0.5
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 0.9 0.4 0.9 -0.9 0.7 -0.9 -0.3 -0.1 0.4 0.5 -0.3
Medication for cholesterol 0.4 0.6 1.8 1.4 -0.1 -0.8 0.2 0.9 -0.4 -0.9 0.3 1.0 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.4 1.4 0.5 0.7 0.8 0.1 1.0 1.6 1.4 1.3 1.3
Back pain experienced in last month 0.5 0.8 1.9 -1.1 -1.1 -1.4 -0.1 -0.8 -0.4 -0.9 -1.0 -0.8 0.0
Mineral and other dietary supplements 0.3 0.5 1.8 0.4 -1.0 0.6 0.1 0.8 1.3 -0.7 -0.2 -0.4 0.2
Breast cancer (self-reported) 0.4 0.5 1.3 -0.9 0.1 -1.1 -0.9 -0.6 -0.4 -0.6 -0.5 0.3 -0.7
Asthma (self-reported) 0.5 1.1 2.3 -0.7 -1.3 -1.2 -0.6 -1.2 -1.0 1.5 -0.3 1.1 0.9
Osteoporosis (self-reported) 0.5 0.6 1.6 0.3 1.3 1.2 -0.3 -0.5 0.0 1.0 -1.2 0.5 0.3
Osteoarthritis (self-reported) 1.2 1.5 4.4 0.7 1.5 2.0 -0.1 -0.4 -0.2 -0.4 -0.6 2.1 -1.9
Medication: Aspirin 0.6 0.7 3.7 -1.2 0.0 1.2 -1.9 -0.3 -0.4 -0.3 0.2 0.3 0.6
Medication: Gliclazide 1.0 1.1 3.0 -0.9 -1.7 0.5 -0.8 -1.2 -0.6 -1.6 -0.8 -0.6 -1.0
Illnesses of father: None of the above (group 1) 1.3 1.6 5.9 1.3 0.7 0.7 0.5 0.0 2.4 1.0 -0.8 2.3 -0.9
Smoking status: Current 0.8 1.3 3.9 -0.5 -1.8 -1.7 0.2 0.1 2.0 -0.0 -0.3 1.1 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.4 -0.4 0.3 1.4 -0.8 -1.6 -1.8 -0.4 -0.7 -1.6 0.3
Whole body water mass 0.3 1.5 7.5 -0.5 0.6 0.2 0.1 -1.3 -0.6 -2.7 -0.3 -2.2 -0.4
Leg predicted mass (right) 0.2 1.2 4.9 -0.0 0.8 0.4 0.6 -0.8 0.1 -2.1 0.9 -2.2 0.3
Arm fat mass (left) 0.2 0.9 3.0 0.4 0.5 0.6 0.5 0.3 0.2 -1.7 1.7 -1.2 0.4
Number of self-reported non-cancer illnesses 0.6 1.1 2.8 -1.2 0.4 1.5 -1.2 -0.9 -0.4 1.7 0.3 -0.6 1.2
Average weekly champagne plus white wine intake 0.8 1.2 4.6 -2.2 0.0 0.4 -1.8 -0.1 -1.6 0.2 0.1 -1.0 0.0
Miserableness 0.5 0.8 4.3 0.7 0.6 -0.5 0.3 -0.0 1.5 0.5 0.6 2.1 0.1
Guilty feelings 0.3 0.4 1.4 -0.2 1.2 -1.1 -0.3 -0.5 0.6 -0.3 0.4 0.5 -0.1
Wears glasses or contact lenses 0.8 1.0 2.7 -0.5 1.4 1.1 -0.2 1.6 0.2 1.2 1.0 0.7 -0.8
Ever taken oral contraceptive pill 1.1 1.3 4.9 -0.9 -0.1 0.6 -0.6 -0.4 -1.6 -1.0 -2.2 -0.4 -1.5
Hearing aid user 1.4 1.5 6.1 2.5 -0.3 0.6 0.8 1.5 1.2 -0.5 1.7 1.2 0.2
Mother’s age at death 0.1 0.2 0.5 -0.4 0.5 0.2 0.3 -0.4 -0.6 0.1 0.0 -0.0 -0.7
Financial situation satisfaction 0.5 0.7 2.1 -0.3 -1.3 -1.0 -0.7 -1.4 -0.8 0.3 0.1 0.7 -0.2
Tinnitus: Yes, now most or all of the time 0.9 1.0 3.0 -1.1 -0.9 -1.7 -1.4 -0.2 0.9 0.3 0.2 -1.3 0.6
Commuting to job workplace: Public transport 0.8 1.0 3.3 -1.0 -1.0 -1.8 -0.9 0.1 0.1 0.4 0.4 -0.9 1.6
Eye problems/disorders: Glaucoma 0.2 0.3 0.8 0.2 0.4 0.8 -0.6 0.5 -0.5 0.9 -0.2 -0.0 0.6
Medication: Blood pressure 0.4 0.8 4.3 -0.1 0.7 1.4 0.2 -0.6 0.2 2.1 -1.0 0.0 0.1
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.9 0.7 0.5 -1.2 0.4 0.8 1.4 -0.1 -0.5 0.9 0.0
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.1 -0.3 1.4 1.0 -0.8 -1.2 -1.1 0.4 -0.4 0.5 -0.8
High cholesterol (Self-reported) 0.8 1.4 7.5 -1.3 -2.7 0.0 -0.8 -1.2 -1.4 0.2 -0.6 0.3 0.3
Medication: Bendroflumethiazide 0.4 0.6 1.7 0.1 0.8 0.1 -0.3 -0.8 0.9 1.2 -1.3 0.2 -0.5
Medication: Paracetamol 0.5 0.7 3.4 -0.4 0.7 0.8 0.5 -0.6 1.2 0.1 0.8 -1.9 -0.0
Medication: Lisinopril 0.8 1.1 3.8 -0.6 -1.0 0.4 0.2 0.5 0.5 0.8 1.9 -1.7 1.3
Medication: Atorvastatin 0.8 1.0 3.4 -1.0 -0.6 0.0 -0.6 -1.3 -0.2 -0.2 -1.2 1.2 -1.8
Illnesses of father: High blood pressure 1.3 1.6 4.4 -1.7 0.7 -1.1 -0.3 -1.2 -1.9 -1.4 -0.1 -2.1 0.3
Alcohol drinker status: Never 0.9 1.1 2.5 -1.5 -1.3 -1.3 -0.4 -0.4 0.1 -1.6 -0.3 -1.4 -0.6
Ever smoked 0.9 1.5 9.1 1.3 0.4 -0.3 1.0 0.4 1.1 1.0 -0.1 3.0 -0.9
Basal metabolic rate 0.2 1.4 6.7 -0.4 0.7 0.4 0.1 -1.1 -0.4 -2.6 0.2 -2.1 -0.2
Leg fat percentage (left) 0.2 0.9 2.8 0.6 0.4 1.6 0.0 0.7 0.9 -1.2 1.7 0.3 -0.1
Arm fat-free mass (left) 0.3 1.6 7.8 -0.6 0.7 0.4 -0.0 -1.2 -0.5 -2.8 -0.0 -2.3 -0.4
Number of operations (self-reported) 1.1 1.7 5.7 -1.0 2.4 1.6 -1.2 -1.4 -0.8 0.0 -0.9 1.1 -1.2
Average weekly beer plus cider intake 0.2 0.3 1.6 -0.3 -0.1 -0.6 0.6 -0.6 0.0 -1.2 -0.4 -0.1 -0.8
Irritability 0.6 1.0 4.6 0.3 0.0 -0.3 0.3 1.0 1.3 1.5 0.1 2.2 -0.3
Risk taking 0.4 0.6 2.1 0.7 0.2 0.3 1.0 1.1 1.4 0.2 0.3 0.3 1.0
Ever had prostate specific antigen (PSA) test 2.5 2.9 7.5 2.1 1.4 -0.7 2.2 2.7 2.4 0.7 1.6 -0.6 0.9
Fractured/broken bones in last 5 years 0.7 0.8 2.4 -0.6 0.9 -0.7 -1.6 -0.6 -1.0 -0.5 -1.0 1.1 -0.8
Age started oral contraceptive pill 0.5 0.7 1.7 1.0 -0.2 -1.2 1.3 0.4 0.2 -0.4 1.1 -0.2 0.9
Diastolic blood pressure, automated reading 0.9 2.9 9.1 -1.2 1.0 1.8 -1.8 -3.0 -2.5 -0.1 -2.0 -0.2 -0.5
Ever depressed for a whole week 0.6 0.7 2.1 -0.3 0.7 1.0 -1.1 -1.5 -1.0 -0.3 0.2 0.9 -0.1
Unable to work because of sickness or disability 2.4 3.2 16.5 -0.4 -0.7 0.5 -0.8 0.1 0.2 2.2 4.1 -0.6 2.9
Commuting to job workplace: Cycle 0.5 0.6 3.6 -0.0 0.3 -0.2 -0.5 -0.7 -1.1 0.8 -0.2 1.9 0.0
Myopia 0.5 0.7 2.5 -1.2 -1.1 -0.2 -0.5 -0.5 -1.6 0.2 0.1 -0.9 0.6
Vascular/heart problems diagnosed by doctor 0.8 2.2 7.7 2.6 0.5 -1.0 2.8 2.0 0.9 -0.1 0.6 0.8 -0.4
Cholesterol lowering medication 0.4 0.6 2.0 -0.7 -1.4 -0.8 0.2 -0.8 0.5 1.1 -0.3 0.9 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 2.3 -1.5 -0.5 0.6 -1.5 -0.4 -1.0 1.3 0.5 -0.4 0.6
Pain experienced in last month 0.2 0.4 1.8 -0.2 0.2 0.5 -0.9 -0.0 -0.3 0.5 1.3 -0.0 0.7
Supplements: Calcium 0.8 0.9 3.5 -0.7 1.2 -1.9 0.3 0.6 0.7 0.8 -0.5 1.0 -0.5
Basal cell carcinoma (self-reported) 0.4 0.5 2.4 0.0 -0.3 1.0 0.0 1.5 0.4 1.0 -0.4 -0.3 -0.5
Heart attack/myocardial infarction (self-reported) 1.5 1.9 3.7 -1.3 -0.1 0.9 -0.7 -1.9 -1.9 -1.7 -1.5 -0.8 -1.7
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.9 0.2 -0.8 -0.9 0.3 0.4 -0.5 -0.6 -0.3 -1.0 -0.8
Heart disease (siblings) 2.0 2.5 6.5 -0.7 -2.0 1.7 -1.5 1.2 -0.7 -1.3 -1.1 2.5 -2.0
Alcohol drinker status: Previous 0.6 0.7 2.3 -0.3 -0.1 -0.8 -0.7 -0.8 -1.5 -0.5 -0.4 -0.7 1.3
Pack years of smoking 0.5 0.7 1.3 1.0 0.1 1.0 1.1 1.1 0.5 0.9 0.8 1.1 0.3
Impedance of whole body 0.4 1.9 5.0 0.4 -1.0 -1.6 -0.8 2.0 0.7 2.2 -0.3 2.2 -0.3
Leg fat mass (left) 0.2 0.9 3.3 0.4 0.7 1.4 -0.1 0.3 0.4 -1.8 1.4 -0.6 -0.1
Arm predicted mass (left) 0.3 1.8 9.8 -0.6 0.5 0.3 0.1 -1.3 -0.5 -3.1 -0.4 -2.1 -0.8