Hub : Genes

REC8

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.087	0.0320	0.0010	-0.002	0.013	0.005	0.014	-0.001	7.9e-01	8.6e-03	7.0e-02	7.3e-03	5.4e-01
2	METSIM	Adipose	0.324	0.0501	0.0000	0.034	0.181	0.181	0.182	0.157	6.9e-06	2.6e-26	2.8e-26	2.0e-26	9.8e-23
3	TCGA	Liver Hepatocellular Carcinoma	0.183	0.0900	0.0048	0.003	0.001	-0.006	NA	-0.006	2.3e-01	3.0e-01	8.7e-01	NA	1.0e+00

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	1.8	2.8	6.0	-1.5	-0.3	-2.5
Bipolar Disorder or Schizophrenia	0.7	1.7	2.8	-1.5	1.7	-0.1
Depressed Affect (Nagel 2018)	1.4	2.9	5.2	-1.7	0.7	-2.3
Depression (Nagel 2018)	0.4	0.6	1.2	0.6	1.1	0.6
Intelligence (Savage-Jansen 2018)	0.5	1.5	2.3	1.5	1.5	-0.0
Neuroticism (Nagel 2018)	0.3	0.7	1.1	-0.8	1.0	-0.6
Schizophrenia (2018)	1.9	4.0	8.1	-0.6	2.8	1.9
Schizophrenia vs Biploar Disorder	1.6	2.1	4.3	2.1	1.2	0.7
Worry (Nagel 2018)	0.2	0.3	0.6	0.2	0.6	0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.2	-0.8	0.1
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.0	0.6	0.8
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.1	-0.5	-0.2
Crohns Disease (2017)	0.5	1.0	2.2	0.8	-0.5	1.5
Irritable Bowel Disease (IBD)	1.0	2.3	6.4	0.6	-0.1	2.5
Ulcerative Colitis (UC)	1.1	2.1	6.3	0.0	0.1	2.5
Major Depression (MDD)	1.9	2.3	4.1	-1.4	-2.0	-0.9
Reaction Time	0.6	1.1	3.1	1.8	-0.3	0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.6	1.3	-0.1	0.0
Breast Cancer	0.7	1.7	3.1	-0.0	1.4	1.8
Ovarian Cancer	0.4	0.6	1.4	1.2	0.4	0.4
Prostate Cancer	1.1	1.5	4.2	-2.1	0.4	-0.3
Age at First Birth	0.4	0.5	1.2	-0.6	1.1	0.2
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.4	0.6	0.0
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	-0.3	0.0	-0.8
Coronary Artery Disease (CAD)	1.3	1.6	3.3	1.1	-1.8	0.4
Crohns Disease (2012)	0.5	0.8	1.9	0.5	0.4	1.4
Mean Putamen Volume	1.6	1.8	4.4	-2.1	0.9	-0.4
Fasting Glucose	1.5	1.7	3.6	1.9	-1.2	-0.4
HbA1C	0.1	0.1	0.4	0.6	0.2	-0.2
HDL Cholesterol	0.4	0.7	1.4	0.3	-0.8	1.2
LDL Cholesterol	0.9	1.4	2.3	1.5	0.9	1.1
Lupus	0.6	1.0	2.4	-1.6	0.6	0.3
Neuroticism (2016)	0.5	0.7	0.8	0.9	-0.8	0.9
Primary Biliary Cirrhosis	0.6	0.8	1.5	-0.3	0.9	1.2
Rheumatoid Arthritis	1.1	1.6	4.5	-0.3	-0.3	-2.1
Schizophrenia (2014)	0.6	1.4	2.6	-0.3	1.6	1.2
Triglycerides	1.2	1.9	3.5	1.4	-0.5	1.9
Type 2 Diabetes (T2D) (2012)	1.1	1.3	3.4	1.9	-0.7	0.0
Ulcerative Colitis	0.5	0.7	1.8	-0.2	0.5	1.3
Blood Eosinophil Count	0.1	0.9	2.4	0.5	0.0	1.6
Blood Platelet Count	0.2	2.7	5.5	-1.5	-0.5	-2.3
Blood Red Count	0.3	2.7	7.9	2.8	0.2	-0.4
Blood White Count	0.1	0.5	1.3	0.1	1.2	-0.1
Heel T-Score	0.6	4.9	8.0	2.8	0.4	2.5
BMI	0.6	3.6	5.2	-2.3	2.3	-0.8
Height	1.2	22.6	32.8	-5.7	-4.7	-3.6
Waist Hip Ratio (WHR)	0.3	1.3	2.4	-1.6	-1.0	0.8
Systolic Blood Pressure	1.0	5.2	11.4	-3.4	-0.9	-1.9
Smoking Status	2.1	5.1	12.1	-3.5	0.7	-1.6
Allergy or Eczema	0.2	0.5	0.7	0.4	-0.8	0.8
Cardiovascular Disease	0.9	3.0	5.9	-2.4	1.7	-0.5
Hypothyroidism (self reported)	0.5	1.1	2.5	-0.8	0.4	1.6
Respiratory disease	0.3	0.6	1.0	0.6	-0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.1	-1.0	0.5	-0.9
Lung FEV1/FVC ratio	0.3	1.6	2.7	-1.4	0.3	-1.6
Lung FVC	0.6	3.0	3.4	-1.5	1.8	-1.8
Neuroticism	0.2	0.4	0.8	-0.6	0.9	-0.2
Chronotype (morning person)	0.3	0.8	1.9	0.4	-1.4	-0.4
Hair Pigment	0.0	0.3	0.8	-0.4	-0.9	-0.1
Tanning	0.1	0.7	1.4	0.2	-1.2	-0.8
Hand grip strength (left)	0.3	0.8	1.5	0.2	1.2	-1.0
Number of treatments/medications taken	2.0	3.6	8.9	-3.0	0.3	-1.3
Average weekly spirits intake	0.9	1.1	2.0	1.4	0.1	-1.2
Sensitivity / hurt feelings	1.3	2.3	4.8	0.9	1.1	2.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.2	-0.2	0.3	-0.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.2	-0.2	-0.4
Relative age of first facial hair	0.3	0.6	1.0	-0.8	-0.4	1.0
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	4.9	-2.2	0.2	0.4
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.1	-1.5	-0.8	0.9
Ever had hysterectomy (womb removed)	0.5	0.5	0.8	-0.7	-0.9	-0.6
Systolic blood pressure, automated reading	0.8	2.4	5.8	-2.4	-0.1	-1.2
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	0.7	0.3	0.3
Angina	2.4	3.1	8.2	2.9	-0.2	1.1
Medication for hormone replacement therapy	0.7	0.8	1.4	0.9	-0.5	1.2
Vitamin and mineral supplements	0.8	1.1	2.9	-0.0	0.7	1.7
Supplements: Zinc	2.4	2.6	6.7	1.0	-2.6	-0.3
Medication: Co-codamol	0.1	0.1	0.2	-0.5	0.1	0.2
Medication: Metformin	1.5	2.1	4.7	-1.3	2.2	0.1
Diabetes (father)	0.7	0.9	1.9	-1.4	0.9	-0.4
Diabetes (mother)	0.2	0.3	0.6	0.2	-0.8	0.3
Severe depression (siblings)	3.9	4.3	8.2	-0.3	2.9	2.2
Pack years adult smoking proportion	0.2	0.3	0.6	-0.8	0.2	-0.4
Impedance of leg (right)	0.5	2.2	3.8	2.0	-0.3	1.6
Leg fat-free mass (left)	0.9	4.8	11.4	-3.4	-0.3	-1.7
Trunk fat percentage	0.5	2.1	3.1	-1.1	1.4	1.8
Hand grip strength (right)	0.2	0.5	1.4	-0.1	1.2	-0.2
Townsend deprivation index at recruitment	0.7	1.0	2.1	-1.5	-0.8	-0.5
Current tobacco smoking	1.7	2.8	6.7	-2.6	0.8	-0.9
Average weekly fortified wine intake	1.3	1.5	2.0	1.0	-1.4	1.2
Maternal smoking around birth	0.2	0.3	0.5	-0.2	0.7	-0.5
Fed-up feelings	1.1	1.9	2.5	-1.6	1.1	-1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.8	0.7	0.9	0.2
Relative age voice broke	0.1	0.1	0.2	-0.5	0.1	0.2
Taking other prescription medications	1.1	1.6	2.7	-1.3	-1.6	-0.6
Age when periods started (menarche)	0.1	0.1	0.2	-0.5	-0.3	-0.3
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.6	-0.8	1.6	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.4	1.6	0.4	0.5
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	-0.6	0.2	-1.2
Qualifications: CSEs or equivalent	0.2	0.2	0.4	0.4	-0.6	0.4
Serious illness, injury or assault to yourself	1.2	1.5	4.2	-2.0	-0.4	0.3
High blood pressure	0.9	2.4	5.3	-2.3	1.0	-1.0
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.5	-0.4	0.6
Multivitamins +/- minerals	0.5	0.6	1.4	0.1	-1.2	-0.7
Stomach or abdominal pain in last month	1.3	1.6	2.6	-1.6	-0.5	-1.4
Supplements: Glucosamine	0.2	0.3	0.6	-0.5	-0.8	0.0
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.3	-0.3	0.2	1.8
Medication: Atenolol	0.5	0.6	0.7	-0.8	0.6	0.9
Medication: Levothyroxine sodium	0.9	1.5	2.3	-0.9	1.5	1.3
Sitting height	0.4	2.5	4.8	-2.2	-1.4	-0.8
Chronic bronchitis/emphysema (father)	0.1	0.1	0.1	0.2	0.2	-0.3
High blood pressure (mother)	0.6	0.8	1.9	0.5	-1.4	0.5
Body mass index (BMI)	0.8	3.3	6.6	-1.8	2.6	0.5
Impedance of leg (left)	0.5	2.4	4.3	2.1	-0.5	1.6
Leg predicted mass (left)	0.9	4.6	11.2	-3.3	-0.2	-1.6
Trunk fat mass	0.5	2.1	4.8	-2.2	1.0	0.7
Waist circumference	1.0	3.7	10.1	-3.2	0.9	0.5
Number of incorrect matches in round	0.5	0.8	1.1	0.9	-0.7	-1.1
Past tobacco smoking	1.4	2.6	5.9	2.4	-0.8	1.1
Alcohol usually taken with meals	0.4	0.7	1.5	1.2	0.0	-0.7
Nervous feelings	0.7	1.4	3.1	0.1	1.0	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.4	1.1	1.1	0.2	0.0
Hearing difficulty/problems with background noise	0.7	1.2	2.7	-0.5	1.6	-0.7
Hair/balding pattern: Pattern 2	0.9	1.1	2.1	-1.4	-0.6	-1.0
Had menopause	0.8	1.1	1.9	-1.1	-1.4	0.0
Had other major operations	1.9	2.3	4.2	-2.1	-1.6	-0.5
Forced vital capacity (FVC)	0.9	3.4	8.6	-1.1	0.6	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	3.3	1.8	0.1	1.2
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	6.4	-0.7	-0.2	-2.5
Qualifications: None of the above	1.6	3.5	7.5	-0.8	-2.7	-1.5
Financial difficulties in last 2 years	0.8	1.1	1.9	1.4	-1.0	0.6
Mouth/teeth dental problems	1.4	2.2	5.3	-0.8	-0.8	-2.3
Heart attack	0.4	0.5	0.6	0.4	0.7	0.8
Allergy	0.5	1.2	3.2	-0.7	0.1	-1.8
Pain all over the body in last month	0.6	0.7	1.2	1.1	-0.6	0.6
Diabetes (self-reported)	0.2	0.3	0.7	-0.8	-0.5	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	2.9	0.2	1.7	0.3
Medication: Ramipril	1.7	2.2	5.1	-1.0	2.3	0.8
Medication: Simvastatin	3.2	4.8	8.0	-2.8	2.4	-0.7
Fluid intelligence score	0.3	0.6	1.0	-0.8	1.0	0.4
Illnesses of siblings	0.7	0.9	1.8	1.4	0.7	-0.7
Neuroticism score	0.1	0.3	0.4	-0.6	0.6	-0.2
Weight	0.9	4.2	11.5	-3.4	0.9	-0.6
Impedance of arm (right)	1.8	8.2	15.4	2.5	-1.7	3.9
Arm fat percentage (right)	0.9	3.6	5.9	-1.5	2.4	1.7
Trunk fat-free mass	1.7	9.6	19.3	-4.4	-0.3	-3.1
Hip circumference	0.5	2.3	5.8	-2.4	0.9	0.4
Time employed in main current job	1.3	1.5	3.3	-0.7	0.8	-1.8
Alcohol intake versus 10 years previously	0.4	0.5	1.1	-0.7	-1.1	-0.1
Father’s age at death	0.5	0.7	1.4	1.2	-0.8	0.2
Worrier / anxious feelings	0.1	0.2	0.6	0.8	-0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	0.5	-0.7	-0.4	-0.7
Falls in the last year	1.2	1.6	4.4	0.4	-2.1	-0.5
Hair/balding pattern: Pattern 3	0.3	0.4	0.8	0.7	-0.9	-0.3
Number of live births	0.5	0.7	1.5	-1.2	-0.8	0.0
Forced expiratory volume in 1-second (FEV1)	1.2	4.0	9.5	-1.6	0.2	-3.1
Pulse rate	1.9	3.3	6.1	2.5	-1.6	1.0
Happiness	0.4	0.5	1.4	1.2	0.3	0.3
Noisy workplace	0.3	0.3	0.6	-0.2	0.6	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.4	-0.1	1.2	-0.8
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.2	0.5	-0.1	-0.7	-0.0
Mouth/teeth dental problems: Dentures	0.1	0.1	0.4	-0.0	-0.1	0.6
Asthma	0.1	0.2	0.4	0.4	0.2	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.0	-0.6	1.0	-0.7
Medication: Cholesterol lowering	0.5	0.8	1.6	-1.3	0.9	0.1
Depression (self-reported)	2.6	3.1	6.8	-1.6	-0.2	-2.6
Medication: Lansoprazole	0.8	0.9	1.7	-0.1	-0.9	1.3
Prospective memory result	0.3	0.4	1.2	-1.1	-0.0	0.2
Lung cancer (father)	4.8	5.6	7.5	-2.7	1.5	-2.7
Illnesses of mother	0.4	0.4	1.3	0.0	1.1	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	7.8	-1.2	0.4	-2.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.4	-0.0	-1.2	-0.4
Impedance of arm (left)	1.8	8.1	14.7	2.8	-1.5	3.8
Arm fat mass (right)	0.9	3.7	6.5	-2.6	2.0	0.6
Trunk predicted mass	1.6	9.3	19.2	-4.4	-0.3	-3.0
Standing height	1.0	9.7	15.4	-3.9	-3.1	-2.1
Length of working week for main job	2.9	3.2	5.3	2.3	-2.0	-0.3
Exposure to tobacco smoke at home	0.7	0.8	1.1	-0.5	-1.0	1.0
Breastfed as a baby	2.2	2.8	7.9	-0.3	-2.8	-0.6
Tense / ‘highly strung’	0.4	0.6	1.6	0.3	0.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	-0.9	1.3	-0.1
Hair/balding pattern: Pattern 4	0.5	1.3	2.9	1.7	0.2	1.0
Birth weight of first child	0.2	0.4	0.6	0.4	-0.7	-0.8
Peak expiratory flow (PEF)	1.1	2.4	4.9	-1.5	0.5	-2.2
Pulse wave reflection index	0.1	0.1	0.2	-0.4	0.4	0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.3	0.4	-0.2
Loud music exposure frequency	2.0	2.2	2.5	1.3	-1.6	1.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	4.0	-1.8	2.0	0.3
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.9	2.0	0.5	1.0
Blood clot in the leg (DVT)	0.3	0.4	0.8	-0.9	-0.5	0.3
Medication: Paracetamol	1.5	2.4	6.8	0.7	-2.6	-0.3
Headache pain in last month	0.7	1.3	2.7	0.4	-1.6	-1.0
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	4.3	2.1	-1.3	-0.3
Glaucoma (self-reported)	0.8	1.0	2.1	0.9	-1.4	-0.1
Gout (self-reported)	2.9	4.0	8.0	-2.8	-1.6	1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.5	-0.3	0.6	1.2
Medication: Amlodipine	0.3	0.5	1.4	-0.0	-0.2	-1.2
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.8	-0.6	0.9	0.8
Birth weight	0.7	1.4	2.8	-1.7	0.7	-1.0
Chronic bronchitis/emphysema (mother)	3.5	4.1	9.3	-1.6	3.0	-0.7
High blood pressure (siblings)	0.5	0.8	1.8	-1.4	-0.6	-0.3
Forced vital capacity (FVC), Best measure	1.2	4.2	11.5	-1.0	0.5	-3.4
Body fat percentage	0.5	1.8	2.2	-1.1	1.5	1.5
Leg fat percentage (right)	0.5	1.8	3.4	-1.1	1.8	0.9
Arm fat-free mass (right)	1.7	8.8	17.5	-4.2	0.4	-3.0
Exposure to tobacco smoke outside home	0.4	0.6	1.2	-0.0	-0.8	1.1
Comparative body size at age 10	2.9	7.9	17.4	-1.7	4.2	-1.9
Number of full brothers	0.6	0.8	1.8	-0.6	-1.3	-0.4
Worry too long after embarrassment	0.0	0.0	0.1	0.1	-0.3	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.0	-1.3	1.7	0.7
Wheeze or whistling in the chest in last year	0.7	1.2	2.7	-0.8	0.6	1.6
Number of children fathered	0.4	0.4	0.7	-0.2	0.7	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.2	-0.5	-0.1	-0.2
Age at first live birth	0.8	1.4	3.5	0.5	1.9	0.5
Pulse wave peak to peak time	0.3	0.4	1.1	-0.2	1.0	0.2
Health satisfaction	0.4	0.5	1.2	0.1	-0.4	1.1
Shortness of breath walking on level ground	1.5	1.8	5.5	-0.2	-2.3	-0.1
Qualifications: College or University degree	0.3	1.0	1.9	0.3	1.4	1.0
Eye problems/disorders: None of the above	1.1	1.3	3.3	0.8	0.2	1.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.2	-1.5	0.9	-0.0
Emphysema/chronic bronchitis	0.3	0.4	0.9	0.4	-0.9	0.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.3	0.6	-0.0
Neck or shoulder pain in last month	1.4	2.0	5.1	0.3	-2.3	-0.9
Medication: Blood pressure	1.3	2.3	3.4	-1.8	1.6	0.9
Angina (self-reported)	1.9	2.6	6.7	2.6	0.0	1.0
Migraine (self-reported)	1.4	1.7	3.6	0.7	-0.9	-1.9
Medication: Ibuprofen	1.4	1.7	3.8	-0.9	1.9	-0.7
Medication: Allopurinol	1.7	2.2	4.2	-2.0	-1.4	0.7
Medication: Omeprazole	1.2	1.4	2.1	-1.5	0.7	-1.3
Medication: Seretide 50 evohaler	0.5	0.5	1.0	-0.7	1.0	-0.1
Mean time to correctly identify matches	1.1	2.1	3.4	1.8	-0.3	1.7
Heart disease (mother)	0.1	0.1	0.2	0.1	-0.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.1	4.2	-0.0	1.5	2.0
Whole body fat mass	0.5	1.9	4.3	-2.1	1.1	0.5
Leg fat mass (right)	0.5	1.9	3.5	-1.9	1.5	0.1
Arm predicted mass (right)	1.8	9.1	17.3	-4.2	0.2	-3.2
Pulse rate, automated reading	0.7	2.3	3.4	1.9	-1.8	0.5
Alcohol intake frequency.	0.4	0.9	2.2	0.0	-1.5	-0.6
Comparative height size at age 10	1.1	5.9	8.8	-3.0	-1.7	-2.5
Number of full sisters	0.5	0.6	1.0	-1.0	-0.4	0.8
Suffer from ‘nerves’	0.4	0.6	0.9	-0.3	0.9	1.0
Overall health rating	0.4	1.0	2.6	-1.6	0.2	0.5
Chest pain or discomfort	0.2	0.2	0.6	0.3	-0.1	0.8
Had major operations	1.6	1.8	3.8	0.3	-1.3	1.9
Age at last live birth	0.1	0.1	0.3	0.1	0.5	-0.4
Family relationship satisfaction	1.1	1.4	3.2	1.0	1.8	-0.1
Leg pain on walking	0.2	0.3	0.8	0.9	0.1	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.5	-0.2	0.5	-1.2
Commuting to job workplace: Car/motor vehicle	2.3	2.6	5.2	2.3	-1.3	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.6	-0.3	1.3	0.0
Medication: Aspirin	0.5	0.6	0.9	0.7	0.7	0.9
Supplements: Vitamin C	0.5	0.6	1.2	1.1	-0.5	-0.6
Knee pain experienced in last month	0.6	0.9	1.8	-0.7	0.7	-1.3
Hypertension (Self-reported)	0.6	1.8	3.8	-2.0	1.0	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.3	0.2	-0.2	-1.2
Illnesses of father: Heart disease	1.0	1.4	3.0	1.0	0.0	1.7
Illnesses of siblings: Diabetes	0.4	0.5	1.3	0.2	-1.1	-0.3
Smoking status: Previous	0.5	0.7	1.5	-1.2	0.7	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.1	4.4	-0.1	-1.3	-2.1
Whole body fat-free mass	1.4	8.2	17.3	-4.2	-0.2	-2.7
Leg fat-free mass (right)	0.9	4.6	10.7	-3.3	-0.4	-1.8
Arm fat percentage (left)	0.8	3.0	5.2	-1.0	2.3	1.7
Average weekly red wine intake	0.3	0.5	1.4	-0.3	1.2	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.7	0.6	1.3	-0.2
Mood swings	0.3	0.6	1.3	-0.7	0.2	-1.1
Loneliness, isolation	1.1	1.5	3.3	-1.1	-0.1	-1.8
Long-standing illness, disability or infirmity	0.8	1.3	2.8	-0.9	-0.5	-1.7
Ever had bowel cancer screening	0.9	1.0	2.2	-1.0	1.5	0.1
Diabetes diagnosed by doctor	0.4	0.7	1.7	-1.3	-0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.6	0.1	0.5
Friendships satisfaction	1.7	2.1	3.7	0.4	1.5	1.9
Qualifications: nursing, teaching	0.1	0.1	0.2	0.5	-0.1	0.1
Commuting to job workplace: Walk	1.5	1.6	2.5	-1.6	-0.2	1.5
Eye problems/disorders: Cataract	0.4	0.5	1.1	-1.0	-0.6	-0.3
Mouth/teeth dental problems: Mouth ulcers	3.0	4.8	7.4	2.7	1.1	2.4
Medication for cholesterol	0.4	0.6	1.0	1.0	-0.8	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.4	6.3	2.5	0.1	1.0
Back pain experienced in last month	0.8	1.2	2.3	1.5	-1.0	-0.5
Mineral and other dietary supplements	2.0	2.7	5.2	-1.7	2.3	-0.2
Breast cancer (self-reported)	1.7	2.0	2.9	-0.7	-1.7	-1.6
Asthma (self-reported)	0.1	0.2	0.6	0.3	0.1	0.8
Osteoporosis (self-reported)	1.6	1.9	3.4	-1.8	-1.1	-1.1
Osteoarthritis (self-reported)	0.4	0.5	0.7	-0.7	-0.5	-0.9
Medication: Aspirin	0.3	0.4	0.6	0.4	0.6	0.8
Medication: Gliclazide	0.7	0.8	2.3	-0.5	-0.0	-1.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.7	-0.0	-0.2	-1.3
Smoking status: Current	1.9	3.1	6.8	-2.6	0.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.9	-0.6	1.0	-0.8
Whole body water mass	1.5	8.6	18.1	-4.3	-0.1	-2.8
Leg predicted mass (right)	0.9	4.8	10.8	-3.3	-0.4	-1.8
Arm fat mass (left)	0.7	3.0	5.1	-2.3	1.9	0.6
Number of self-reported non-cancer illnesses	2.1	3.7	6.7	-2.6	1.7	-1.2
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-0.9	-1.0	-0.6
Miserableness	1.6	2.8	4.4	-2.0	-0.0	-2.1
Guilty feelings	0.7	1.1	3.0	-1.7	-0.3	-0.5
Wears glasses or contact lenses	1.4	1.6	4.1	-0.9	-2.0	0.3
Ever taken oral contraceptive pill	0.6	0.7	0.8	0.9	-0.8	-0.9
Hearing aid user	0.5	0.5	0.7	-0.5	-0.8	-0.8
Mother’s age at death	0.1	0.1	0.3	0.4	0.5	-0.1
Financial situation satisfaction	0.4	0.4	1.0	-1.0	0.2	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.7	1.2	0.2
Commuting to job workplace: Public transport	1.2	1.4	2.4	-1.5	0.3	1.3
Eye problems/disorders: Glaucoma	1.3	1.5	2.6	1.6	-0.8	1.1
Medication: Blood pressure	1.7	3.2	7.3	-2.7	0.5	-1.4
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.9	0.2	-0.1
Supplements: Fish oil (including cod liver oil)	2.0	2.6	4.4	1.7	-2.1	0.6
High cholesterol (Self-reported)	0.7	1.2	1.5	-1.2	1.2	-0.7
Medication: Bendroflumethiazide	1.3	2.0	3.2	-1.8	1.4	-0.9
Medication: Paracetamol	0.4	0.7	1.5	0.6	-1.2	-0.3
Medication: Lisinopril	1.6	2.1	4.2	-2.0	1.2	-0.8
Medication: Atorvastatin	0.4	0.5	1.1	0.5	-0.2	1.0
Illnesses of father: High blood pressure	1.8	2.2	4.7	0.3	-1.4	2.2
Alcohol drinker status: Never	0.2	0.2	0.7	0.1	-0.1	-0.8
Ever smoked	0.8	1.4	3.6	-1.9	0.6	-0.6
Basal metabolic rate	1.3	7.3	16.9	-4.1	0.1	-2.2
Leg fat percentage (left)	0.4	1.3	2.3	-0.8	1.5	0.9
Arm fat-free mass (left)	1.9	9.6	21.2	-4.6	0.4	-2.7
Number of operations (self-reported)	0.5	0.8	1.8	-1.4	-0.6	-0.4
Average weekly beer plus cider intake	0.6	0.9	2.0	-1.4	0.8	0.1
Irritability	1.1	1.9	4.5	-0.3	2.1	-1.1
Risk taking	0.2	0.4	0.6	-0.8	0.4	0.5
Ever had prostate specific antigen (PSA) test	1.6	1.9	4.6	-1.0	0.3	-2.1
Fractured/broken bones in last 5 years	0.6	0.8	2.0	-1.4	-0.5	0.0
Age started oral contraceptive pill	0.9	1.2	3.4	-0.0	-1.8	-0.4
Diastolic blood pressure, automated reading	1.2	3.6	10.5	-3.2	0.6	-0.0
Ever depressed for a whole week	1.1	1.3	2.6	-1.6	-0.6	-1.0
Unable to work because of sickness or disability	0.1	0.1	0.2	0.1	-0.4	0.3
Commuting to job workplace: Cycle	0.8	0.9	1.4	-1.1	1.2	-0.3
Myopia	1.9	2.7	4.6	1.5	-2.1	-1.2
Vascular/heart problems diagnosed by doctor	0.8	2.1	3.7	1.9	-1.3	0.9
Cholesterol lowering medication	0.5	0.8	2.3	0.1	1.5	0.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	0.5	-0.7	0.6	-0.7
Pain experienced in last month	0.7	1.2	2.6	-0.8	1.6	0.6
Supplements: Calcium	1.9	2.1	4.3	0.7	-2.1	-1.3
Basal cell carcinoma (self-reported)	0.7	0.8	1.8	1.3	-0.3	-0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	0.6	0.8	0.8
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.1	-1.0	-0.3	0.3
Heart disease (siblings)	0.1	0.2	0.3	0.2	-0.4	0.6
Alcohol drinker status: Previous	0.1	0.1	0.2	-0.4	-0.2	0.0
Pack years of smoking	0.2	0.3	0.7	-0.8	0.1	-0.3
Impedance of whole body	1.2	6.1	10.1	2.5	-1.4	3.2
Leg fat mass (left)	0.4	1.5	3.0	-1.7	1.2	0.1
Arm predicted mass (left)	2.1	10.6	23.3	-4.8	0.4	-2.9