TWAS hub - REPS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1440	0.0490	4.3e-03	0.044	NA	0.036	NA	0.044	3.0e-04	NA	1.1e-03	NA	2.9e-04
2	GTEx	Esophagus Mucosa	0.3520	0.0680	3.9e-08	0.181	NA	0.061	NA	0.155	3.6e-12	NA	6.9e-05	NA	1.5e-10
3	GTEx	Pituitary	0.4590	0.1030	3.4e-04	0.197	NA	0.135	NA	0.238	1.1e-05	NA	3.0e-04	NA	1.1e-06
4	GTEx	Testis	0.2050	0.0640	5.8e-04	0.074	NA	0.061	NA	0.071	3.6e-04	NA	1.1e-03	NA	4.3e-04
5	NTR	Blood	0.0217	0.0080	1.6e-03	0.006	0.007	0.006	0.007	0.007	3.8e-03	0.0025	3.8e-03	0.0019	1.6e-03
6	TCGA	Head and Neck Squamous Cell Carcinoma	0.0253	0.0132	4.6e-03	0.023	0.013	0.004	NA	0.009	1.2e-03	0.0120	1.1e-01	NA	3.1e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
High cholesterol (Self-reported)	4.9	8.7	20.9	2.8	-0.7	-1.5	-2.2	4.1	4.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.5	5.2	12.0	1.1	-3.5	-1.4	2.2	-2.8	-1.9
Cholesterol lowering medication	3.9	5.7	18.3	1.8	-0.8	-1.3	-0.1	3.2	4.3
Ever had hysterectomy (womb removed)	3.0	3.4	9.8	0.3	-1.7	-1.6	1.8	1.4	3.1
Medication: Omeprazole	2.9	3.5	5.9	0.5	-2.0	-1.7	2.1	-2.4	-1.9
Osteoarthritis (self-reported)	2.8	3.6	9.1	0.9	-1.6	-0.6	1.8	-3.0	-2.4
Ever taken oral contraceptive pill	2.6	2.9	5.4	-1.4	-0.5	0.4	2.1	-2.3	-2.3
Medication: Ibuprofen	2.5	3.0	7.1	0.3	1.9	0.1	0.5	-2.7	-2.7
Average weekly beer plus cider intake	2.5	3.6	8.9	3.0	2.0	0.8	-1.6	1.6	1.8
Age at First Birth	2.4	3.6	10.4	1.4	1.2	1.0	-1.1	-2.3	-3.2
Medication: Metformin	2.4	3.4	8.4	0.5	-0.6	-1.4	-2.9	2.7	1.4
Mean Putamen Volume	2.2	2.6	5.7	-0.8	2.1	2.4	-0.5	-1.0	-1.8
Shortness of breath walking on level ground	2.2	2.6	5.4	0.5	-0.2	-0.1	2.3	-2.3	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.6	14.5	-1.4	1.1	0.3	0.6	-3.1	-3.8
Diabetes (self-reported)	2.1	3.3	11.1	1.1	0.3	0.5	-3.3	2.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.1	2.7	7.3	-0.0	1.4	0.2	0.6	-2.6	-2.7
Prospective memory result	1.9	2.4	3.4	0.8	-1.6	-1.8	1.4	-1.8	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	3.5	1.8	-1.9	-1.4	0.5	1.1	1.8
Reaction Time	1.8	3.5	13.1	0.3	2.3	0.1	-3.6	0.8	-1.4
Medication for hormone replacement therapy	1.8	2.0	5.9	-2.4	0.4	-0.3	2.3	-0.4	0.8
Medication: Simvastatin	1.8	2.6	6.2	1.0	-0.5	-0.5	-1.6	2.5	2.3
Exposure to tobacco smoke at home	1.8	2.0	5.3	-1.0	-1.5	-1.1	1.1	1.1	2.3
Illnesses of siblings: Diabetes	1.7	2.0	5.5	1.4	-1.9	-2.3	-1.1	0.1	0.1
Illnesses of siblings	1.6	2.3	6.9	-1.5	2.6	1.9	0.3	-0.5	-0.7
Medication: Seretide 50 evohaler	1.6	1.9	4.6	0.9	-1.2	-1.4	-2.1	1.5	0.6
Mean time to correctly identify matches	1.6	3.1	13.0	1.4	1.0	-0.5	-3.6	1.3	-0.6
Knee pain experienced in last month	1.6	2.5	5.1	1.5	-1.4	-1.1	1.3	-2.3	-1.6
Neuroticism (2016)	1.5	2.2	4.7	2.1	-0.2	0.0	0.8	-2.2	-1.8
Sensitivity / hurt feelings	1.5	2.5	5.1	2.3	0.4	0.4	2.1	-2.2	-0.8
Mouth/teeth dental problems	1.5	2.3	4.9	1.1	0.2	-0.8	-2.2	2.0	1.7
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	6.0	-1.0	0.5	1.4	2.5	-1.2	0.0
Medication: Cholesterol lowering	1.5	2.3	4.7	1.1	-1.2	-0.0	-1.8	2.2	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.2	5.4	0.6	2.3	1.8	0.2	1.1	1.7
Long-standing illness, disability or infirmity	1.5	2.3	4.1	1.4	-2.0	-1.7	1.9	0.1	1.0
Systolic blood pressure, automated reading	1.4	4.1	10.3	1.3	-3.2	-3.1	1.6	-0.7	0.1
Falls in the last year	1.4	1.9	4.2	1.1	0.8	2.0	1.8	-1.4	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	8.7	-1.0	0.1	-0.4	2.9	-1.8	-0.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.4	0.3	-1.3	-1.2	1.6	-1.8	-1.1
Ulcerative Colitis (UC)	1.3	2.5	4.7	-1.9	-1.9	-0.4	2.2	-1.3	-1.0
Triglycerides	1.3	2.1	5.5	1.4	0.9	1.3	0.3	1.7	2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	8.2	-1.6	1.1	1.3	0.2	-2.0	-2.9
Medication: Ramipril	1.3	1.6	4.5	0.7	-0.2	0.6	0.9	-1.9	-2.1
Medication for cholesterol, blood pressure or diabetes	1.3	2.2	4.2	-1.5	2.0	1.0	1.5	-1.4	-1.1
Neck or shoulder pain in last month	1.3	1.8	6.9	0.3	-0.9	0.0	0.9	1.5	2.6
Diabetes diagnosed by doctor	1.3	2.1	4.8	0.7	0.0	-0.0	-2.2	2.2	1.5
Medication for cholesterol	1.3	1.9	5.1	0.4	0.8	1.4	-1.3	-1.3	-2.3
Back pain experienced in last month	1.3	2.0	8.2	2.9	0.6	-0.0	-0.0	0.9	1.6
Wears glasses or contact lenses	1.3	1.5	4.1	0.7	-2.0	-2.0	-0.6	-0.0	-0.4
Breast Cancer	1.2	2.9	6.4	2.5	-0.0	-1.6	-0.2	-2.0	-2.2
Ulcerative Colitis	1.2	1.8	3.8	-1.4	-1.6	-0.6	2.0	-1.1	-0.9
Chronotype (morning person)	1.2	2.7	7.9	-0.9	-0.1	0.0	-2.6	-1.0	-2.8
Taking other prescription medications	1.2	1.9	4.0	2.0	-2.0	-1.7	-0.1	0.6	0.7
Had menopause	1.2	1.4	3.2	0.4	-1.3	-1.8	0.5	1.0	1.6
Pulse wave Arterial Stiffness index	1.2	1.4	2.3	1.4	-1.0	-1.0	1.3	-1.5	-0.7
Tense / ‘highly strung’	1.2	1.9	6.2	-1.2	1.9	2.5	-0.3	0.2	-0.0
Pulse wave reflection index	1.2	1.4	4.9	0.3	0.7	0.4	1.1	-2.2	-1.4
Illnesses of father: Heart disease	1.2	1.6	3.6	-1.8	0.1	-0.1	-1.0	1.9	1.4
Leg fat-free mass (right)	1.2	6.4	20.9	-1.6	0.5	0.2	1.2	-3.6	-4.6
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.2	3.3	0.9	1.6	1.8	0.6	-0.0	0.6
Leg predicted mass (right)	1.2	6.4	20.7	-1.7	0.6	0.1	1.3	-3.6	-4.5
Number of self-reported non-cancer illnesses	1.2	2.2	4.0	1.9	-2.0	-1.9	0.4	0.5	1.2
Commuting to job workplace: Cycle	1.2	1.5	4.2	0.4	1.2	1.2	0.3	1.2	2.0
Bipolar Disorder (2011)	1.1	1.0	2.6	0.9	-0.8	-0.4	0.9	-1.6	-1.1
LDL Cholesterol	1.1	1.7	6.7	2.6	0.4	0.6	-0.2	1.1	1.4
Rheumatoid Arthritis	1.1	1.6	3.7	-0.7	1.9	1.5	1.2	0.3	1.2
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.0	0.9	1.7	0.9	0.2	1.0	1.5
Financial difficulties in last 2 years	1.1	1.5	3.4	0.2	-1.7	-1.8	1.5	-0.8	0.0
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	7.6	-2.0	1.2	0.8	1.6	-2.8	-2.4
Illnesses of mother	1.1	1.4	3.4	-1.4	1.8	1.4	-0.1	0.7	0.7
Pulse wave peak to peak time	1.1	1.3	2.1	-1.4	1.0	0.9	-1.4	1.4	0.4
Comparative height size at age 10	1.1	6.3	17.0	-0.7	-1.6	-2.2	0.3	-3.6	-4.1
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	3.1	-0.7	1.1	1.1	-1.5	0.1	-1.8
Medication: Gliclazide	1.1	1.2	3.7	0.5	-0.8	-0.1	-1.9	1.5	0.5
Pain experienced in last month	1.1	1.8	4.1	-1.6	1.2	0.9	-0.7	-1.1	-2.0
Bipolar Disorder (2018)	1.0	1.5	4.2	0.9	-0.2	0.1	-1.0	-1.8	-2.0
Bipolar Disorder or Schizophrenia	1.0	2.4	7.2	1.1	-0.5	0.7	-1.4	-1.9	-2.7
Heel T-Score	1.0	8.3	16.2	-3.3	0.1	1.2	2.5	-3.9	-4.0
Hand grip strength (left)	1.0	2.7	7.2	-0.8	1.4	0.2	0.9	-2.3	-2.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.2	1.2	0.7	0.3	1.4	-1.8	-0.9
Diabetes (mother)	1.0	1.3	4.3	2.1	-1.0	-1.4	0.1	0.0	0.3
Leg fat-free mass (left)	1.0	5.1	17.5	-1.4	-0.1	-0.3	0.8	-3.2	-4.2
Fed-up feelings	1.0	1.8	5.3	1.0	0.5	0.5	2.3	-1.9	-0.8
Forced vital capacity (FVC)	1.0	4.0	7.0	-2.6	1.3	1.2	1.6	-2.5	-2.2
Breastfed as a baby	1.0	1.2	2.4	-0.4	-1.5	-1.6	-1.4	0.5	-0.5
Birth weight of first child	1.0	1.9	5.2	0.4	0.1	0.8	2.3	-2.2	-0.9
Emphysema/chronic bronchitis	1.0	1.1	3.2	0.3	-1.2	-0.8	1.8	-1.0	-0.2
Medication: Allopurinol	1.0	1.3	3.5	1.9	-1.0	-1.7	-0.6	0.1	0.3
Illnesses of father: None of the above (group 1)	1.0	1.2	3.8	-0.2	1.7	2.0	0.3	-0.6	-0.6
Financial situation satisfaction	1.0	1.2	3.3	1.5	-0.9	-0.4	1.8	-0.6	0.3
Risk taking	1.0	1.5	4.0	-0.6	0.0	0.9	0.7	-2.0	-1.8
Irritable Bowel Disease (IBD)	0.9	2.1	3.9	-1.3	-2.0	-1.0	1.8	-1.3	-0.8
Smoking Status	0.9	2.2	4.1	-1.8	0.2	1.6	-2.0	1.8	-0.3
Type 2 Diabetes (T2D) (2018)	0.9	1.7	7.4	1.3	0.0	0.5	-2.7	0.8	-0.5
Vitamin and mineral supplements	0.9	1.2	2.3	-1.5	-0.6	-1.0	1.4	-1.0	-0.7
Pack years adult smoking proportion	0.9	1.3	4.1	-0.5	-0.2	0.4	0.5	1.7	2.0
Hand grip strength (right)	0.9	2.4	5.4	-0.8	1.4	0.4	1.2	-2.2	-2.3
Current tobacco smoking	0.9	1.5	5.1	-0.3	0.4	0.6	-2.3	1.8	0.0
Stomach or abdominal pain in last month	0.9	1.2	3.1	1.8	1.0	-1.6	0.2	-0.2	0.4
Chronic bronchitis/emphysema (father)	0.9	1.1	2.7	0.7	-1.7	-1.4	0.5	-0.8	-0.6
Leg predicted mass (left)	0.9	5.0	17.1	-1.4	-0.1	-0.3	0.9	-3.2	-4.1
Pulse rate	0.9	1.5	4.6	2.1	-1.7	-0.0	0.1	-0.7	-1.0
Happiness	0.9	1.1	2.8	1.7	-1.2	-1.4	0.6	-0.3	-0.1
Peak expiratory flow (PEF)	0.9	2.0	5.1	-0.7	0.9	0.2	1.7	-2.3	-1.7
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.5	0.5	-1.7	-1.9	-0.3	-0.4	-0.6
Number of children fathered	0.9	1.0	3.3	-0.7	-1.2	-1.8	0.9	-0.0	0.5
Health satisfaction	0.9	1.2	2.2	1.0	-1.2	-1.2	1.5	-0.8	-0.5
Overall health rating	0.9	1.9	5.8	1.7	-1.0	-0.6	2.4	-1.0	0.4
Diastolic blood pressure, automated reading	0.9	2.8	5.6	1.2	-1.5	-2.4	1.5	-2.1	-1.1
Pack years of smoking	0.9	1.3	3.7	-0.7	-0.7	0.1	0.8	1.6	1.9
Major Depression (MDD)	0.8	1.0	2.0	1.4	0.8	1.0	-0.1	-1.0	-1.0
Height	0.8	14.6	46.2	0.2	1.7	1.8	0.4	-5.9	-6.8
Medication: Co-codamol	0.8	1.0	1.6	-0.6	0.9	0.9	1.3	-1.2	-0.8
Severe depression (siblings)	0.8	0.9	3.9	0.3	1.2	2.0	-0.1	-0.2	0.0
Medication: Levothyroxine sodium	0.8	1.3	3.3	1.8	-0.5	0.5	1.2	-1.5	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.6	-1.8	1.6	1.3	0.8	-2.1	-1.7
Standing height	0.8	8.3	27.1	-2.1	0.4	-0.3	0.5	-4.2	-5.2
Blood clot in the leg (DVT)	0.8	1.0	1.8	0.2	0.9	1.3	0.7	-1.3	-0.9
Comparative body size at age 10	0.8	2.1	5.4	1.5	-0.0	-0.6	-2.3	1.7	1.3
Number of full brothers	0.8	1.0	3.1	0.2	-1.6	-1.8	0.4	-0.2	-0.1
Angina (self-reported)	0.8	1.1	4.8	-0.3	-2.2	-0.9	0.7	0.3	0.2
Suffer from ‘nerves’	0.8	1.3	3.1	-0.7	0.9	1.0	-0.1	1.4	1.8
Whole body fat-free mass	0.8	4.7	15.6	-1.3	0.7	0.3	0.7	-3.2	-4.0
Smoking status: Current	0.8	1.3	5.3	-0.1	-0.2	0.3	-2.3	1.5	-0.3
Whole body water mass	0.8	4.7	15.3	-1.3	0.7	0.3	0.8	-3.2	-3.9
Basal metabolic rate	0.8	4.2	13.5	-1.5	0.5	0.1	0.8	-2.9	-3.7
Irritability	0.8	1.4	4.3	0.2	2.1	1.9	0.0	0.5	0.2
Fractured/broken bones in last 5 years	0.8	1.0	1.7	-0.7	-1.2	-1.0	0.5	-1.1	-1.3
Ever depressed for a whole week	0.8	0.9	2.9	1.7	0.1	0.4	0.4	0.7	1.4
Supplements: Calcium	0.8	0.9	2.5	-0.1	-0.1	-0.2	-0.7	1.6	1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	0.3	0.8	1.1	0.8	-1.5	-1.2
Depressed Affect (Nagel 2018)	0.7	1.4	3.7	1.9	-0.6	-0.1	1.4	-1.5	-0.3
Depression (Nagel 2018)	0.7	1.1	2.1	0.7	1.0	0.3	1.2	-1.4	-1.2
Alzheimer’s Disease (in father)	0.7	0.8	2.0	-0.2	-0.8	-1.3	1.4	-0.7	-0.1
Hypothyroidism (self reported)	0.7	1.6	7.1	2.7	0.7	0.4	0.6	-0.3	1.2
Lung FEV1/FVC ratio	0.7	3.4	7.3	0.7	-2.3	-2.7	1.1	-1.9	-1.6
Average weekly spirits intake	0.7	0.8	1.5	-1.2	-1.2	-0.3	0.5	-0.6	-1.1
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.9	1.0	-1.4	-0.8	0.9	-1.0	-0.5
Impedance of leg (right)	0.7	3.3	9.9	0.3	0.1	-0.2	-1.5	2.8	3.1
Maternal smoking around birth	0.7	1.0	2.8	-0.2	0.1	-1.5	1.7	-0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	4.5	-1.4	0.7	1.1	-0.0	-1.3	-2.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.3	0.9	-1.5	0.1	-0.2	0.7	0.8
Qualifications: CSEs or equivalent	0.7	1.0	3.7	0.2	0.1	0.1	1.1	0.9	1.9
Multivitamins +/- minerals	0.7	0.9	1.8	1.4	0.7	1.0	-1.0	0.8	0.8
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	1.5	0.9	-1.0	-0.7	0.9	0.5	1.2
Heart attack	0.7	0.9	2.0	-1.0	-0.1	0.6	-1.2	1.4	0.6
Pain all over the body in last month	0.7	0.8	2.1	-0.5	1.1	0.8	1.5	-0.5	-0.3
Trunk fat-free mass	0.7	4.1	12.5	-1.2	0.9	0.5	0.7	-3.0	-3.5
Father’s age at death	0.7	0.9	3.1	-0.0	1.8	1.2	-1.0	0.1	0.1
Number of live births	0.7	1.0	3.8	-0.3	0.2	1.1	1.9	-0.8	-0.0
Mouth/teeth dental problems: Dentures	0.7	1.1	2.3	-0.9	-1.2	-0.2	0.8	-1.2	-1.5
Trunk predicted mass	0.7	3.9	11.8	-1.1	0.9	0.5	0.6	-2.9	-3.4
Loud music exposure frequency	0.7	0.7	1.8	0.1	-1.1	-0.1	-0.2	1.2	1.3
High blood pressure (siblings)	0.7	1.0	3.7	1.9	-1.1	-0.1	0.0	0.5	1.0
Exposure to tobacco smoke outside home	0.7	1.0	2.2	-1.0	-0.5	-0.7	-0.3	1.4	1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.1	-0.3	0.2	1.8	0.2	-0.9	-0.9
Medication: Blood pressure	0.7	1.3	2.6	1.1	-1.6	-1.4	-1.2	0.4	-0.0
Heart disease (mother)	0.7	0.8	2.2	1.5	-1.2	-0.8	-0.8	-0.1	-0.2
Number of full sisters	0.7	0.9	2.6	0.1	-1.1	-0.9	-1.6	-0.0	-0.8
Smoking status: Previous	0.7	1.0	3.4	-1.9	0.5	0.9	0.6	0.9	0.8
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.4	0.3	-0.1	0.2	-1.4	-0.6	-1.5
Mood swings	0.7	1.2	4.9	2.2	-0.0	0.3	1.0	-1.1	-0.3
Qualifications: nursing, teaching	0.7	1.0	2.3	-1.0	1.1	1.5	-0.9	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	4.7	-0.6	-0.6	-1.6	2.2	-0.5	1.2
Miserableness	0.7	1.2	2.7	1.3	0.1	0.7	0.7	-1.6	-1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.0	-0.3	-1.4	-1.2	-0.8	0.7	0.1
Medication: Bendroflumethiazide	0.7	1.0	2.9	0.3	-1.0	-0.9	-0.4	-0.9	-1.7
Alcohol drinker status: Previous	0.7	0.8	1.9	-1.4	-0.9	-0.7	-0.3	1.1	0.6
Ovarian Cancer	0.6	0.8	1.8	-0.4	-1.3	-0.7	0.2	-0.9	-1.3
Body Mass Index (BMI) (2010)	0.6	0.8	2.1	-0.1	1.4	1.4	-0.3	-0.2	-0.9
Lupus	0.6	0.9	2.1	0.5	-1.4	-1.5	-1.1	0.2	-0.4
Blood Eosinophil Count	0.6	4.8	15.7	-0.6	-0.7	-0.6	0.7	-3.4	-4.0
Cardiovascular Disease	0.6	2.1	8.9	3.0	-1.0	-1.1	0.3	-0.2	1.2
Lung FVC	0.6	3.1	10.3	-1.9	0.6	1.3	3.2	-0.7	1.4
Number of treatments/medications taken	0.6	1.1	2.3	1.5	-1.4	-1.4	0.5	-0.2	0.3
Impedance of leg (left)	0.6	2.8	8.1	-0.2	1.0	0.3	-1.1	2.5	2.8
Qualifications: None of the above	0.6	1.2	2.5	1.1	-1.0	-1.2	0.8	0.6	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.8	0.8	-0.4	-0.7	1.9	-0.7	0.4
Forced vital capacity (FVC), Best measure	0.6	2.3	3.9	-2.0	1.4	1.4	0.6	-1.8	-1.5
Wheeze or whistling in the chest in last year	0.6	1.0	1.8	-0.6	-1.2	-0.9	0.8	-1.1	-1.3
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.6	-0.6	1.0	1.3	0.8	-0.4	-0.4
Chest pain or discomfort	0.6	0.8	1.7	0.3	1.3	1.1	-0.0	-0.8	-1.1
Guilty feelings	0.6	0.9	2.2	-1.1	1.3	1.5	-0.5	0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.7	2.5	0.7	0.2	-0.2	-0.1	1.1	1.6
Medication: Atorvastatin	0.6	0.7	2.2	1.0	-0.1	-0.1	-0.2	1.0	1.5
Illnesses of father: High blood pressure	0.6	0.7	1.7	-0.6	1.1	-0.7	-0.2	-0.8	-1.3
Alcohol drinker status: Never	0.6	0.7	2.2	0.5	0.3	0.5	1.5	-1.3	0.1
Schizophrenia (2018)	0.5	1.1	3.2	0.7	-0.5	0.8	-0.9	-1.0	-1.8
Crohns Disease (2012)	0.5	0.7	2.0	-1.0	-0.8	0.2	1.4	-0.8	0.3
Schizophrenia (2014)	0.5	1.0	3.0	0.6	-0.0	1.7	-0.7	-0.8	-1.3
Angina	0.5	0.7	3.2	-0.5	-1.8	-0.6	0.2	0.7	0.3
Townsend deprivation index at recruitment	0.5	0.7	1.3	0.0	0.9	1.1	-0.8	1.0	0.9
Average weekly fortified wine intake	0.5	0.6	1.9	0.1	-1.4	-0.6	-0.2	-0.8	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	0.5	0.3	-0.6	1.0	-1.4	-0.6
Supplements: Glucosamine	0.5	0.6	1.3	-0.5	-1.1	-0.3	0.9	-1.0	-0.4
Sitting height	0.5	3.7	7.8	-2.4	0.4	-0.3	1.6	-2.8	-2.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.4	-0.4	0.8	1.0	-0.1	1.1	1.2
Time employed in main current job	0.5	0.5	1.4	-0.4	-1.2	-0.2	0.3	0.8	0.9
Worrier / anxious feelings	0.5	0.9	3.0	1.7	-1.1	-0.9	-0.3	0.3	0.5
Hair/balding pattern: Pattern 3	0.5	0.8	2.8	-0.2	0.6	0.8	-0.1	1.0	1.7
Lung cancer (father)	0.5	0.6	1.7	0.6	-0.7	-0.0	-0.7	-0.9	-1.3
Gout (self-reported)	0.5	0.7	1.9	1.4	-0.2	-0.6	-1.0	-0.5	-0.6
Medication: Amlodipine	0.5	0.8	1.5	0.7	-0.7	-1.2	0.9	0.2	1.1
Birth weight	0.5	1.1	3.3	0.1	-0.9	-1.3	1.8	-0.9	0.0
Leg fat percentage (right)	0.5	1.7	4.5	-0.1	-0.6	-1.1	-0.3	2.0	2.1
Arm fat-free mass (right)	0.5	2.7	7.9	-1.1	0.8	0.8	0.5	-2.3	-2.8
Age at first live birth	0.5	0.8	2.2	-0.3	-1.4	-1.5	-0.4	-0.5	-0.6
Medication for pain relief, constipation, heartburn	0.5	0.8	1.6	-1.2	0.6	0.5	-0.1	1.1	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.6	-0.5	0.7	0.2	1.6	-0.6	-0.3
Arm predicted mass (right)	0.5	2.5	7.1	-1.1	0.7	0.7	0.6	-2.3	-2.7
Had major operations	0.5	0.6	1.1	1.0	-0.4	0.4	1.0	-1.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.4	-1.2	0.4	-0.4	0.9	0.4	1.0
Commuting to job workplace: Walk	0.5	0.5	1.9	-0.1	-1.4	-1.0	0.1	0.4	0.3
Mineral and other dietary supplements	0.5	0.7	2.2	-0.9	0.1	0.0	0.0	-0.9	-1.5
Medication: Aspirin	0.5	0.6	2.9	0.4	-1.7	-0.8	0.3	0.1	0.3
Arm fat-free mass (left)	0.5	2.3	6.4	-0.9	1.0	0.9	0.6	-2.1	-2.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	2.0	-0.8	-0.4	0.2	1.4	-0.5	-0.0
Age started oral contraceptive pill	0.5	0.6	1.3	0.9	-1.2	0.1	0.6	-0.8	-0.9
Myopia	0.5	0.7	2.8	0.6	-0.5	-0.6	-1.7	0.7	-0.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.5	-1.0	-0.2	0.5	-1.1	1.2	0.5
Arm predicted mass (left)	0.5	2.4	7.1	-0.8	0.9	0.6	0.7	-2.3	-2.7
Neuroticism (Nagel 2018)	0.4	1.0	2.4	1.6	0.4	1.1	1.1	-0.9	0.2
Worry (Nagel 2018)	0.4	0.9	2.0	0.5	1.1	1.4	0.3	0.5	1.2
Primary Biliary Cirrhosis	0.4	0.5	1.2	-1.1	0.6	-0.2	-0.8	-0.2	-0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.6	-1.0	-0.0	0.1	-1.3	0.4	-0.4
Blood Platelet Count	0.4	5.1	9.5	1.9	1.5	2.2	-1.4	2.8	3.1
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	0.3	0.3	-0.6	1.1	0.3	1.0
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.4	-1.2	0.2	-0.4	0.8	0.4	0.5
High blood pressure (mother)	0.4	0.6	1.9	0.3	-1.2	-1.4	0.2	-0.0	0.0
Nervous feelings	0.4	0.7	2.0	0.4	0.2	1.4	1.3	-0.7	0.1
Weight	0.4	2.1	6.0	-1.6	-0.3	-0.8	0.5	-1.8	-2.4
Depression (self-reported)	0.4	0.5	1.0	0.6	0.8	1.0	0.3	0.6	0.9
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.9	-0.4	-0.9	0.2	0.7	-0.9	-0.7
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.1	0.2	-0.5	0.9	0.1	-0.6	-1.0
Breast cancer (self-reported)	0.4	0.5	1.3	0.1	0.4	-1.1	-0.9	0.9	0.3
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	1.1	0.1	0.9	-0.6	0.7	0.3
Medication: Lisinopril	0.4	0.5	0.8	-0.9	-0.4	-0.9	0.6	-0.5	-0.7
Ever smoked	0.4	0.8	1.7	-1.0	0.4	0.4	-1.2	1.3	-0.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.6	0.7	0.6	0.4	-1.3	0.3	-0.2
Schizophrenia vs Biploar Disorder	0.3	0.5	1.0	0.2	1.0	0.7	-0.9	-0.0	-0.5
Alzheimer’s Disease (in mother)	0.3	0.4	1.3	0.0	1.1	0.4	-0.7	-0.2	-0.7
Fasting Glucose	0.3	0.4	0.9	0.9	1.0	0.2	-0.4	0.3	-0.4
HDL Cholesterol	0.3	0.4	1.6	0.1	-1.3	-0.9	-0.2	-0.2	-0.2
Systolic Blood Pressure	0.3	1.5	4.0	0.9	-2.0	-1.9	0.8	-0.5	0.1
Allergy or Eczema	0.3	0.8	2.9	0.2	-1.7	-1.3	0.1	-0.2	-0.2
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.8	0.4	-0.5	-0.9	-0.6	0.4	0.5
Supplements: Zinc	0.3	0.4	0.6	-0.8	-0.8	0.0	0.5	0.5	0.7
Diabetes (father)	0.3	0.3	1.1	-1.0	-0.1	-0.5	0.5	-0.6	-0.4
Trunk fat percentage	0.3	1.2	3.2	-1.5	-1.3	-1.8	0.0	0.2	-0.6
Relative age voice broke	0.3	0.4	2.2	0.0	1.5	0.0	0.3	-0.4	-0.2
Age when periods started (menarche)	0.3	0.8	2.4	-0.5	1.6	0.5	-0.9	-0.4	-0.9
Medication: Atenolol	0.3	0.4	0.7	0.4	-0.8	-0.6	-0.6	0.5	0.8
Trunk fat mass	0.3	1.4	2.9	-1.7	-1.1	-1.6	0.1	-0.4	-1.2
Number of incorrect matches in round	0.3	0.4	1.3	0.5	-0.1	0.3	0.4	0.8	1.1
Hearing difficulty/problems with background noise	0.3	0.4	1.1	1.1	0.1	-0.3	0.7	0.2	0.9
Allergy	0.3	0.7	1.2	-0.6	1.1	0.9	-0.6	0.9	0.7
Neuroticism score	0.3	0.7	1.8	1.4	1.0	0.9	0.4	-0.5	0.1
Noisy workplace	0.3	0.3	0.9	1.0	-0.4	0.3	0.6	-0.7	-0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.9	-1.4	-0.9	0.5	-0.8	0.1	-0.5
Asthma	0.3	0.6	2.0	0.2	-0.5	-0.5	0.1	-0.9	-1.4
Medication: Lansoprazole	0.3	0.3	0.9	0.4	-0.7	1.0	-0.3	0.4	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	3.0	0.5	-0.8	-0.4	1.7	-0.7	0.0
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.1	0.8	0.8	0.3	0.7	0.5
Medication: Paracetamol	0.3	0.5	0.7	0.8	0.9	0.4	0.4	-0.7	-0.8
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.9	1.7	0.4	-0.2	0.6	-0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.8	0.2	0.9	-0.2	-0.6	0.9	0.8
Qualifications: College or University degree	0.3	1.1	3.3	-0.5	-0.1	1.0	-0.6	-1.3	-1.8
Migraine (self-reported)	0.3	0.3	0.9	-0.6	0.1	-1.0	0.4	0.2	0.6
Family relationship satisfaction	0.3	0.3	0.7	0.7	-0.1	-0.7	-0.8	0.6	0.2
Leg pain on walking	0.3	0.4	0.8	-0.1	0.1	0.5	0.8	-0.8	-0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.4	0.4	-0.4	-1.2	0.2	-0.4	-0.5
Medication: Aspirin	0.3	0.4	2.3	0.3	-1.5	-0.2	0.3	0.0	-0.0
Ever had bowel cancer screening	0.3	0.3	0.9	0.3	0.0	-0.5	0.8	-0.9	-0.4
Eye problems/disorders: Cataract	0.3	0.3	1.6	1.2	0.1	0.1	-0.2	0.4	0.4
Hearing aid user	0.3	0.4	1.2	0.1	-1.1	-0.3	0.9	-0.3	0.1
Commuting to job workplace: Public transport	0.3	0.3	0.8	-0.4	0.2	0.6	0.9	-0.6	-0.2
Leg fat percentage (left)	0.3	1.2	3.1	-0.5	-0.2	-0.9	-0.2	1.8	1.7
Number of operations (self-reported)	0.3	0.5	2.3	-0.3	0.1	0.4	1.5	-0.5	0.3
Crohns Disease (2017)	0.2	0.5	1.1	-0.2	-0.8	-0.5	1.0	-0.9	-0.1
Coronary Artery Disease (CAD)	0.2	0.3	0.9	-0.3	-1.0	0.1	-0.5	0.6	0.3
HbA1C	0.2	0.2	0.5	0.1	0.7	0.6	-0.6	-0.1	-0.4
Blood White Count	0.2	1.2	3.6	-1.9	-1.1	-1.0	-0.2	0.0	-1.1
Waist Hip Ratio (WHR)	0.2	1.0	2.7	-0.5	-0.2	-0.9	-0.9	1.6	1.1
Respiratory disease	0.2	0.5	1.2	0.9	-0.8	-1.1	-0.2	-0.2	-0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.3	-0.8	-1.0	-0.2	0.2	-0.0
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.7	0.3	0.9	0.4	-0.2	0.2
High blood pressure	0.2	0.4	1.1	0.8	-0.3	-1.1	0.5	0.1	0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.2	-0.5	-1.0	-1.1	0.1	0.3	0.2
Waist circumference	0.2	0.6	1.3	-1.1	-0.9	-1.1	-0.0	0.2	-0.4
Past tobacco smoking	0.2	0.4	1.2	1.1	-0.1	-0.6	-0.1	-0.9	-0.4
Alcohol usually taken with meals	0.2	0.4	1.6	-0.2	0.3	0.3	-1.2	-0.2	-0.7
Hair/balding pattern: Pattern 2	0.2	0.3	0.6	-0.7	0.4	0.3	-0.3	-0.1	-0.8
Had other major operations	0.2	0.3	0.7	0.0	0.3	-0.9	-0.7	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	1.1	-0.4	-0.1	-0.2	-1.0	-0.0	0.2
Arm fat percentage (right)	0.2	0.7	2.0	-1.1	-0.8	-1.4	0.2	0.6	0.2
Hip circumference	0.2	1.0	2.0	-1.0	-0.6	-1.4	0.4	-0.9	-1.3
Alcohol intake versus 10 years previously	0.2	0.4	0.9	-0.4	-0.1	0.2	1.0	-0.8	-0.7
Arm fat mass (right)	0.2	0.9	2.2	-1.5	-0.6	-1.0	0.5	-0.5	-1.1
Headache pain in last month	0.2	0.4	1.8	1.3	-0.0	-0.5	0.1	-0.5	-0.4
Glaucoma (self-reported)	0.2	0.3	0.8	0.1	-0.9	-0.7	0.5	-0.4	-0.0
Body fat percentage	0.2	0.9	2.2	-1.1	-1.0	-1.5	-0.3	0.9	0.3
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.0	0.7	0.5	0.4	0.4	0.5
Whole body fat mass	0.2	0.8	1.8	-1.3	-0.7	-1.4	0.1	-0.2	-0.8
Pulse rate, automated reading	0.2	0.8	2.7	0.4	-1.6	-1.3	-0.2	0.4	-0.2
Alcohol intake frequency.	0.2	0.5	0.9	-0.6	-0.7	-0.8	0.9	0.4	0.9
Age at last live birth	0.2	0.2	1.2	0.2	-1.1	-0.5	0.0	-0.1	0.0
Supplements: Vitamin C	0.2	0.3	1.0	-0.5	-0.6	-0.3	1.0	-0.1	0.2
Hypertension (Self-reported)	0.2	0.7	1.9	1.4	-0.4	-1.3	0.2	0.1	0.5
Arm fat percentage (left)	0.2	0.6	1.6	-1.1	-0.8	-1.3	0.2	0.4	-0.1
Loneliness, isolation	0.2	0.2	0.6	0.6	0.0	0.3	0.3	-0.8	-0.4
Friendships satisfaction	0.2	0.2	0.8	0.9	0.4	-0.2	0.1	-0.2	-0.3
Asthma (self-reported)	0.2	0.4	1.5	-0.0	-0.3	-0.4	-0.3	-0.6	-1.2
Arm fat mass (left)	0.2	0.8	2.0	-1.4	-0.4	-0.8	0.3	-0.6	-1.3
Average weekly champagne plus white wine intake	0.2	0.3	1.5	-0.2	-1.2	-0.5	0.1	0.2	0.2
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	-0.6	-0.4	-0.4	-0.6	0.4	0.2
Medication: Blood pressure	0.2	0.4	0.8	0.4	-0.6	-0.6	0.9	-0.5	-0.5
Medication: Paracetamol	0.2	0.3	0.8	0.8	0.9	0.3	-0.0	-0.1	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	-0.9	0.7	1.0	-0.3	-0.3	-0.8
Heart disease (siblings)	0.2	0.2	0.4	0.7	-0.3	-0.3	-0.4	0.6	0.5
Impedance of whole body	0.2	1.0	2.7	-0.3	-0.0	-0.6	-1.2	1.6	1.3
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.3	-0.2	0.3	-0.9	-0.1	-0.8
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.6	-0.0	-0.6	0.4	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	-0.2	-0.6	-0.7	-0.5	0.0	-0.2
Blood Red Count	0.1	0.9	2.0	-1.0	-0.4	-1.0	0.5	-1.4	-1.1
BMI	0.1	0.8	2.5	0.5	-0.4	0.3	0.2	-1.3	-1.6
Neuroticism	0.1	0.3	0.9	0.9	0.4	0.1	0.5	-0.2	0.4
Tanning	0.1	1.1	2.8	-0.9	-1.5	-1.7	0.1	0.0	-0.9
Relative age of first facial hair	0.1	0.2	0.5	-0.1	0.4	-0.7	0.4	-0.2	0.3
Body mass index (BMI)	0.1	0.3	0.6	-0.8	-0.6	-0.8	0.5	-0.1	-0.3
Fluid intelligence score	0.1	0.3	0.9	0.3	-0.7	-1.0	-0.5	-0.0	-0.2
Impedance of arm (right)	0.1	0.7	2.5	-0.4	-0.7	-1.6	-0.9	0.5	-0.2
Impedance of arm (left)	0.1	0.6	1.6	-0.8	-0.9	-1.2	-0.5	0.3	-0.4
Length of working week for main job	0.1	0.1	0.4	-0.3	-0.4	-0.0	-0.2	0.7	-0.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.5	0.5	0.0	-0.0	-0.7	0.7	0.4
Worry too long after embarrassment	0.1	0.2	0.9	1.0	-0.3	0.2	0.3	-0.3	-0.2
Leg fat mass (right)	0.1	0.2	0.8	-0.9	-0.3	-0.7	0.0	0.3	-0.0
Average weekly red wine intake	0.1	0.2	0.4	-0.2	-0.5	-0.5	0.3	-0.2	-0.6
Osteoporosis (self-reported)	0.1	0.1	0.3	-0.6	-0.2	0.5	0.1	0.4	0.2
Unable to work because of sickness or disability	0.1	0.2	0.8	0.9	-0.1	0.1	-0.4	0.2	-0.2
Leg fat mass (left)	0.1	0.3	1.3	-1.1	-0.2	-0.6	0.1	0.2	-0.3
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.8	3.6	-0.2	-1.9	-0.6	0.6	-0.3	-0.0
Mother’s age at death	0.0	0.1	0.3	0.1	0.0	0.1	0.2	0.1	0.5

Hub : Genes

REPS1

Models

Trait associations