Hub : Genes

RFTN1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0860	0.0320	2.5e-03	0.002	0.009	0.002	0.011	0.003	1.8e-01	2.3e-02	1.7e-01	1.4e-02	1.1e-01
2	GTEx	Artery Aorta	0.2540	0.0720	5.9e-04	0.166	NA	0.119	NA	0.135	1.9e-09	NA	4.6e-07	NA	6.8e-08
3	GTEx	Artery Tibial	0.2194	0.0563	5.3e-06	0.059	NA	0.097	NA	0.010	2.0e-05	NA	5.2e-08	NA	5.5e-02
4	GTEx	Esophagus Muscularis	0.2700	0.0610	2.2e-06	0.102	NA	0.280	NA	0.248	9.8e-07	NA	3.0e-17	NA	3.1e-15
5	GTEx	Thyroid	0.1490	0.0520	1.2e-03	0.024	NA	0.070	NA	0.037	5.6e-03	NA	4.5e-06	NA	7.6e-04
6	YFS	Blood	0.0834	0.0189	9.8e-11	0.043	0.040	0.055	0.049	0.041	6.1e-14	4.6e-13	2.6e-17	1.2e-15	2.4e-13
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0724	0.0271	1.1e-04	0.020	0.049	0.054	NA	0.043	2.5e-03	3.0e-06	9.4e-07	NA	1.3e-05
8	TCGA	Brain Lower Grade Glioma	0.0755	0.0303	3.3e-03	-0.002	0.010	0.002	NA	-0.001	6.8e-01	2.4e-02	1.9e-01	NA	4.9e-01
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.1010	0.0400	7.2e-04	0.078	0.049	0.072	NA	0.075	5.5e-06	2.8e-04	1.4e-05	NA	8.5e-06
10	TCGA	Prostate Adenocarcinoma	0.0738	0.0281	1.9e-04	0.077	0.050	0.076	NA	0.085	2.0e-08	6.1e-06	2.5e-08	NA	3.5e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.0	1.6	12.1	-1.1	0.3	-0.5	-0.0	3.5	0.5	-0.3	1.2	0.6	0.9
Bipolar Disorder or Schizophrenia	0.7	1.6	6.4	-1.1	-1.1	-1.3	-0.6	2.5	0.9	1.2	1.4	0.8	-0.3
Depressed Affect (Nagel 2018)	1.1	2.3	5.5	-1.1	1.8	0.9	2.4	0.3	-1.9	-1.7	0.2	-1.4	1.8
Depression (Nagel 2018)	0.5	0.8	2.8	-1.2	0.1	0.2	1.1	0.4	-1.7	-0.7	-0.2	-1.3	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.6	7.7	-0.8	2.8	1.2	-1.8	-0.0	-0.1	1.0	-0.5	0.3	-1.3
Neuroticism (Nagel 2018)	0.8	1.9	6.4	-1.1	2.5	1.5	1.5	0.6	-1.5	-1.5	-0.2	-1.5	0.5
Schizophrenia (2018)	0.5	1.1	2.9	-0.4	-1.7	-1.2	-0.8	0.4	0.8	1.7	0.9	0.6	-1.1
Schizophrenia vs Biploar Disorder	0.5	0.7	2.7	0.7	-0.7	-1.6	0.7	-0.5	-1.1	0.7	0.8	-0.0	0.4
Worry (Nagel 2018)	0.9	1.8	6.9	0.2	2.6	1.1	0.9	0.4	-1.7	-1.1	0.1	-2.2	-0.5
Alzheimer’s Disease (in mother)	1.6	1.8	4.8	-0.0	1.5	1.8	0.1	-2.2	-1.7	0.1	-1.0	-2.0	-0.5
Alzheimer’s Disease (in father)	1.5	1.6	6.7	-2.6	-0.0	0.6	1.0	-1.3	-1.7	-1.1	-1.0	-0.5	1.1
Alzheimer’s Disease (including proxy)	1.6	2.2	6.4	-2.5	1.3	1.5	0.3	-1.9	-2.5	0.5	-1.4	-0.4	-0.3
Crohns Disease (2017)	0.2	0.5	1.5	0.4	-1.1	0.4	0.0	0.3	1.0	-1.2	-0.5	-0.3	-0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.8	0.3	-0.5	0.1	-0.0	1.2	1.4	-0.7	0.6	0.5	-0.4
Ulcerative Colitis (UC)	0.4	0.8	3.3	0.3	0.5	0.1	0.6	1.8	1.1	-0.5	1.2	0.8	0.4
Major Depression (MDD)	1.7	2.1	5.2	-2.3	1.8	1.0	-1.6	-0.9	-0.6	1.4	0.2	0.8	-2.2
Reaction Time	0.9	1.7	5.6	0.3	2.4	2.3	0.2	0.2	0.8	1.1	1.8	0.4	0.6
Verbal and Numeric Reasoning (VNR)	0.4	1.0	4.9	-0.5	2.2	1.4	-0.7	-0.1	-0.6	0.9	0.3	0.5	-1.1
Breast Cancer	1.1	2.6	6.7	2.6	-1.9	0.6	2.1	-0.0	-1.1	-1.7	0.8	-2.0	1.3
Ovarian Cancer	0.5	0.7	1.8	-1.0	1.4	1.3	-0.4	-0.9	-0.5	0.5	-0.1	0.0	-0.7
Prostate Cancer	1.2	1.7	3.8	-2.0	1.7	0.2	0.5	1.6	-1.8	-0.2	-1.5	-0.5	1.0
Age at First Birth	0.5	0.7	3.0	-0.7	-0.6	-0.9	-0.1	1.7	0.1	-1.1	-0.4	0.9	-0.7
Bipolar Disorder (2011)	0.6	0.5	3.5	-0.8	-0.4	-0.4	0.3	1.9	0.5	0.2	0.1	-0.7	0.1
Body Mass Index (BMI) (2010)	0.3	0.4	1.4	1.2	0.1	0.6	0.7	-0.3	0.1	-0.7	-0.0	-0.3	1.0
Coronary Artery Disease (CAD)	1.6	1.9	17.3	0.8	-4.2	-0.5	-0.3	-0.6	0.4	0.4	0.3	0.3	-0.2
Crohns Disease (2012)	0.2	0.3	0.7	0.2	-0.3	-0.2	-0.6	-0.5	0.7	-0.5	0.6	-0.2	-0.8
Mean Putamen Volume	1.6	1.8	6.8	-0.3	0.7	-0.4	-2.3	-0.8	-0.3	1.2	-1.6	-0.8	-2.6
Fasting Glucose	1.2	1.4	2.9	1.1	1.1	1.7	1.6	0.4	-1.7	-0.8	0.5	-0.3	1.5
HbA1C	1.0	1.1	3.7	-0.5	0.1	0.5	-1.9	0.7	0.4	1.4	1.3	0.9	-1.3
HDL Cholesterol	0.4	0.7	4.5	-0.8	0.1	-0.7	-1.1	2.1	0.1	-0.0	-0.2	0.3	-0.4
LDL Cholesterol	0.3	0.4	1.6	0.5	-1.2	0.6	0.1	-0.7	-0.1	-0.7	-0.8	-0.3	0.2
Lupus	0.8	1.3	4.3	-1.1	-0.1	0.7	-0.4	1.2	0.7	2.1	0.7	2.0	0.2
Neuroticism (2016)	1.3	1.8	4.8	-1.7	2.2	1.3	-1.3	0.4	1.0	0.9	-1.6	0.1	-1.6
Primary Biliary Cirrhosis	1.0	1.5	6.2	0.7	0.3	-1.2	0.7	-0.7	-2.5	-1.2	-0.1	-1.2	-1.7
Rheumatoid Arthritis	0.6	0.8	2.9	1.7	-1.1	-0.0	0.9	-0.8	-0.5	0.6	-0.2	-0.7	1.3
Schizophrenia (2014)	0.7	1.5	3.9	-1.4	-1.4	-1.3	0.2	2.0	-0.0	1.6	1.7	0.3	-0.2
Triglycerides	0.6	1.0	5.6	0.4	-2.4	-1.2	0.9	0.5	0.7	-0.1	0.1	-0.3	0.8
Type 2 Diabetes (T2D) (2012)	0.9	1.1	4.4	1.2	1.0	0.6	1.5	-0.2	-0.6	-0.1	-0.2	-2.1	0.9
Ulcerative Colitis	0.3	0.5	1.3	0.4	1.0	-0.2	-0.5	-0.2	0.5	0.6	1.0	0.6	-1.2
Blood Eosinophil Count	0.2	1.2	4.0	1.0	-0.9	-0.6	-1.4	0.2	0.6	-1.7	0.2	1.0	-2.0
Blood Platelet Count	0.2	2.0	6.6	0.2	-2.3	-2.6	-1.2	1.3	1.8	-0.4	-0.8	1.1	-0.4
Blood Red Count	0.5	5.0	44.5	6.7	0.4	1.3	0.1	-1.0	-1.0	-0.4	0.5	-0.8	0.5
Blood White Count	0.4	2.8	9.2	1.6	-1.8	-0.5	2.8	-0.3	-1.1	-1.5	0.8	-0.6	3.0
Heel T-Score	0.2	1.9	8.1	0.7	1.5	1.8	-0.1	-2.8	-1.0	-0.9	-1.8	-0.4	-0.6
BMI	0.5	2.8	12.0	3.5	-0.6	1.1	-0.1	-0.3	-0.0	-3.0	1.0	-1.7	1.3
Height	0.1	2.3	4.0	1.5	1.1	1.6	2.0	-1.6	-0.7	-0.3	-1.6	-1.8	2.0
Waist Hip Ratio (WHR)	0.2	0.9	4.6	0.5	2.1	1.5	0.6	-0.3	-0.5	0.8	0.9	-0.4	0.1
Systolic Blood Pressure	0.4	2.1	10.2	-0.4	-1.9	0.4	0.3	-1.3	-0.4	3.2	-1.9	-0.1	-1.1
Smoking Status	1.1	2.5	8.8	1.9	-3.0	-1.0	-0.8	1.7	2.2	-0.9	0.8	1.3	-0.4
Allergy or Eczema	1.4	3.6	6.7	-1.7	1.4	-0.2	-1.9	1.3	2.4	2.5	1.1	2.6	-2.6
Cardiovascular Disease	0.4	1.5	3.5	0.5	-0.8	1.8	0.7	-1.9	-1.7	-0.1	-1.2	-1.4	0.8
Hypothyroidism (self reported)	0.3	0.6	1.9	0.1	0.4	0.8	-1.0	-0.9	-0.1	-0.2	1.2	-1.4	0.3
Respiratory disease	0.9	1.9	4.5	-0.2	0.7	-0.4	-2.1	1.5	1.5	-0.2	1.0	2.0	-2.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.8	0.5	-0.8	-0.7	-0.7	-1.4	0.8	-1.2	0.7	-1.0	-0.4
Lung FEV1/FVC ratio	0.7	3.3	7.7	-1.5	-0.4	-1.6	2.8	-1.2	-2.6	-1.6	0.1	-2.5	1.7
Lung FVC	0.5	2.8	6.4	-1.2	1.3	0.8	-2.3	-0.9	2.5	2.3	-0.9	1.8	-1.5
Neuroticism	1.6	3.8	7.8	-2.0	2.7	1.5	1.8	0.7	-2.6	-1.6	-0.4	-2.8	1.7
Chronotype (morning person)	0.2	0.4	1.3	0.7	-0.1	-0.8	0.5	0.1	1.1	-0.4	1.1	0.3	0.4
Hair Pigment	0.0	1.1	2.5	0.6	-1.5	-0.0	1.5	-1.6	-0.7	-0.7	0.2	-1.6	0.8
Tanning	0.2	2.1	7.9	-0.9	-1.1	-1.4	-1.4	2.8	1.5	0.2	1.1	2.1	0.0
Hand grip strength (left)	0.3	0.7	1.9	-1.2	-0.1	0.4	-0.5	0.4	0.2	-1.3	-1.4	-0.1	-1.0
Number of treatments/medications taken	0.2	0.4	1.9	0.1	0.4	-0.3	-0.2	-0.5	0.1	1.0	0.6	0.4	-1.4
Average weekly spirits intake	0.9	1.1	2.5	1.5	0.4	0.9	-0.9	-0.7	1.6	-0.1	-0.2	1.3	-1.4
Sensitivity / hurt feelings	0.5	0.9	2.6	-1.1	0.9	1.0	0.9	0.9	-0.5	-0.3	1.6	-0.7	1.0
Frequency of depressed mood in last 2 weeks	1.3	1.8	4.5	-1.3	-0.6	0.0	1.9	-0.6	-1.7	-0.7	-0.4	-1.9	2.1
Hearing difficulty/problems: Yes	0.9	1.3	3.6	0.9	1.1	0.8	-1.2	0.6	0.7	0.8	1.9	1.8	-0.8
Relative age of first facial hair	0.6	1.1	2.5	-0.7	-1.3	-0.9	1.4	1.6	0.7	0.8	-0.8	-0.2	1.4
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	4.4	-0.3	0.1	0.0	2.1	-0.5	-1.5	-0.4	-0.1	-2.0	1.7
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.3	1.1	-2.1	-1.9	-1.6	0.4	0.5	0.1	1.3	1.1	-1.2
Ever had hysterectomy (womb removed)	0.6	0.7	1.8	0.8	-0.9	0.4	1.3	-0.5	0.1	1.2	0.1	0.7	1.1
Systolic blood pressure, automated reading	0.4	1.1	3.7	1.1	-0.4	0.7	-0.5	-1.4	-0.5	1.4	-1.9	-0.7	-0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	1.4	0.0	-1.4	-0.5	0.3	1.1	-0.2	0.3	1.0	-1.1
Angina	0.9	1.2	4.3	2.1	-1.7	-1.2	-1.0	0.3	1.2	-0.2	-0.2	0.2	-0.7
Medication for hormone replacement therapy	1.2	1.3	3.4	0.8	-1.2	-1.7	-0.8	0.9	1.8	0.2	-0.1	1.6	-1.0
Vitamin and mineral supplements	0.7	0.9	3.6	0.4	-1.9	0.5	0.7	1.1	0.9	1.0	0.8	0.0	1.2
Supplements: Zinc	1.0	1.1	2.9	-1.0	1.0	-0.3	-1.2	-0.8	-0.9	-0.4	-1.0	-1.2	-1.7
Medication: Co-codamol	1.0	1.2	4.1	-0.3	-0.9	-2.0	-1.3	0.1	0.4	0.9	-0.4	0.5	-1.9
Medication: Metformin	0.7	1.0	3.3	-0.3	-0.7	-1.8	-1.4	0.4	1.4	0.2	0.7	1.1	-0.1
Diabetes (father)	0.9	1.1	4.6	-0.1	0.0	-1.8	-1.5	-0.2	0.1	-0.2	0.0	-0.4	-2.1
Diabetes (mother)	0.8	1.0	4.4	1.0	0.3	0.7	0.1	-1.0	0.2	2.1	-0.4	1.5	0.5
Severe depression (siblings)	0.6	0.7	1.9	-0.9	-0.3	-1.4	-0.5	0.3	1.1	0.2	-0.3	1.2	-0.7
Pack years adult smoking proportion	1.0	1.5	9.1	3.0	-1.8	-0.1	0.6	0.3	0.7	-0.9	0.1	0.4	1.0
Impedance of leg (right)	0.4	1.9	6.1	-1.7	-2.5	-0.8	0.9	0.4	0.8	2.3	0.6	1.4	0.6
Leg fat-free mass (left)	0.6	3.4	7.0	2.6	2.5	2.6	1.3	-1.3	-1.2	-1.7	-0.5	-2.3	1.3
Trunk fat percentage	0.8	3.2	9.7	3.1	0.1	1.9	1.7	-1.7	-0.4	-0.7	1.5	-1.7	2.7
Hand grip strength (right)	0.3	0.8	3.3	-1.0	-0.5	-0.2	-0.9	0.8	0.5	-0.6	-1.8	0.1	-1.1
Townsend deprivation index at recruitment	1.1	1.6	5.1	-0.0	-2.3	-2.0	1.1	1.1	-0.3	-1.4	-0.2	-0.4	1.4
Current tobacco smoking	1.5	2.5	7.0	1.7	-2.6	-0.6	-0.6	1.4	2.5	0.1	1.1	2.0	-0.2
Average weekly fortified wine intake	2.1	2.5	10.9	0.9	-0.2	-1.1	-1.9	-1.5	-0.1	-0.4	-2.4	0.7	-3.3
Maternal smoking around birth	0.6	0.9	1.5	-0.9	1.2	1.2	-0.8	-1.2	-0.9	-0.3	-1.2	-0.6	-0.1
Fed-up feelings	1.9	3.4	6.5	-1.3	1.9	2.1	1.8	-1.0	-2.5	-2.3	-1.1	-2.1	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.8	-1.0	-0.1	0.0	1.3	-0.5	-1.4	0.1	-0.3	-0.5	0.9
Relative age voice broke	0.3	0.5	1.8	-0.1	1.0	-0.2	0.0	1.4	0.9	0.2	-0.8	-0.1	-0.0
Taking other prescription medications	0.3	0.4	1.1	0.5	-0.1	-1.0	-0.0	-1.0	-0.6	-0.4	0.5	-0.3	-1.0
Age when periods started (menarche)	0.1	0.3	1.3	1.1	0.1	-1.1	0.5	-0.7	-0.1	0.0	-0.0	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	1.4	1.7	5.5	2.3	-1.6	0.7	1.0	-0.9	-0.1	-1.8	-0.6	-1.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.6	-0.2	1.1	1.4	-0.2	-1.6	-0.3	-0.9	-0.8	-0.7	-0.0
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	4.9	-0.9	-2.2	-2.0	-0.2	-0.7	0.0	0.5	-0.9	-0.7	-1.2
Qualifications: CSEs or equivalent	1.9	2.5	4.7	1.5	0.8	2.1	1.5	-1.9	-1.3	-2.2	-0.6	-2.1	0.9
Serious illness, injury or assault to yourself	0.5	0.7	1.9	0.3	-0.1	-0.3	1.4	-0.3	-1.1	-1.1	0.3	0.1	1.4
High blood pressure	0.4	1.0	4.5	0.9	-1.1	0.5	-0.0	-2.1	-1.2	1.2	-0.1	-0.7	-0.5
Hayfever, allergic rhinitis or eczema	1.5	3.3	7.4	-1.4	0.6	-0.8	-1.6	2.0	2.0	2.2	1.2	2.4	-2.7
Multivitamins +/- minerals	0.9	1.2	5.3	-2.3	1.3	-0.7	-0.7	-0.1	-1.0	-0.8	-0.7	-0.1	-1.3
Stomach or abdominal pain in last month	0.6	0.8	3.5	-0.4	1.9	-0.0	0.9	1.2	0.1	-0.4	0.3	-0.2	1.2
Supplements: Glucosamine	0.7	1.0	3.1	1.0	0.9	1.1	-0.9	-1.8	-0.1	-1.2	-0.7	-0.9	-0.2
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	3.4	-1.9	-0.1	-0.4	0.0	-1.0	-0.1	0.6	-1.2	0.5	-0.6
Medication: Atenolol	0.7	0.9	3.3	1.8	-0.9	1.2	0.7	0.1	-0.5	0.2	1.1	0.6	1.0
Medication: Levothyroxine sodium	0.3	0.5	1.9	-0.6	1.4	-0.1	0.4	-0.5	-1.1	0.4	0.2	-1.0	0.6
Sitting height	0.6	4.4	10.0	0.2	1.2	2.2	2.3	-1.6	-3.2	-1.5	-3.0	-2.9	0.7
Chronic bronchitis/emphysema (father)	1.1	1.3	7.3	-1.1	2.7	0.7	0.9	-0.9	-0.7	0.3	0.0	-0.4	1.0
High blood pressure (mother)	0.6	0.8	3.8	1.1	1.9	1.0	-0.1	-0.5	0.8	0.8	0.5	-0.1	0.3
Body mass index (BMI)	0.6	2.5	11.0	3.3	0.2	0.9	0.5	-1.2	-0.3	-2.1	1.3	-1.8	1.4
Impedance of leg (left)	0.3	1.4	4.5	-1.9	-2.1	-0.6	0.9	0.1	0.2	2.0	0.5	0.6	0.8
Leg predicted mass (left)	0.7	3.6	7.2	2.6	2.5	2.7	1.3	-1.3	-1.2	-1.7	-0.6	-2.4	1.3
Trunk fat mass	0.9	4.0	12.5	3.5	0.6	2.2	2.0	-1.9	-0.8	-1.3	0.9	-2.2	2.6
Waist circumference	0.7	2.6	11.6	3.4	0.3	1.1	1.2	-1.8	-0.5	-1.4	0.8	-1.7	1.7
Number of incorrect matches in round	0.4	0.7	3.5	-1.9	-0.3	-0.8	-0.3	1.0	-0.1	0.9	0.1	-0.4	0.2
Past tobacco smoking	0.6	1.1	3.0	-0.7	1.1	1.7	1.1	-0.5	-0.6	1.0	1.3	0.1	1.5
Alcohol usually taken with meals	0.5	0.8	4.0	-1.3	2.0	1.3	-0.2	0.4	-0.3	0.0	0.1	-0.8	-0.0
Nervous feelings	0.3	0.5	1.4	-0.6	1.1	0.4	0.1	1.2	-0.5	-0.1	1.0	-0.9	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.7	-0.6	-0.5	0.9	1.3	-0.8	-1.2	0.2	0.2	-1.1	1.1
Hearing difficulty/problems with background noise	1.1	1.7	4.5	-0.7	1.1	-0.5	-0.8	2.1	0.8	-0.1	1.7	1.8	-1.7
Hair/balding pattern: Pattern 2	1.0	1.3	4.4	1.6	-2.1	-0.7	-0.9	1.3	1.2	-1.1	-0.2	0.5	-0.2
Had menopause	0.4	0.5	1.3	0.6	-1.1	-0.9	-0.9	0.1	0.9	0.7	0.4	0.5	-0.5
Had other major operations	0.6	0.7	1.9	-0.5	-0.9	-0.9	1.4	0.3	1.1	-1.0	0.3	0.8	0.4
Forced vital capacity (FVC)	0.4	1.5	4.8	-1.7	1.1	1.2	-0.6	-0.8	0.3	1.6	-2.2	-0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.5	0.7	0.5	-0.5	-0.8	0.7	-0.1	-0.8	0.3	-0.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	2.3	1.2	0.6	1.2	1.4	-1.1	-0.2	-0.1	0.7	0.1	1.5
Qualifications: None of the above	1.3	2.8	15.9	4.0	-2.7	-0.5	0.5	-1.1	0.1	-1.5	0.1	-0.4	0.8
Financial difficulties in last 2 years	0.4	0.6	2.3	0.4	-1.5	-0.9	0.4	-0.2	1.2	-0.0	0.7	0.2	0.4
Mouth/teeth dental problems	0.1	0.2	0.5	-0.5	-0.7	-0.5	0.4	0.3	-0.5	-0.3	0.2	-0.4	0.3
Heart attack	0.7	0.9	5.1	2.3	0.2	0.9	0.9	0.3	0.8	-0.6	0.9	0.1	0.6
Allergy	1.1	2.6	6.8	1.6	-0.7	0.8	1.3	-2.6	-1.7	-1.1	-0.3	-2.4	2.0
Pain all over the body in last month	1.0	1.1	3.1	-0.2	0.1	-1.8	-1.0	1.0	1.0	1.2	0.5	1.4	-1.1
Diabetes (self-reported)	0.3	0.4	1.6	0.8	0.4	-0.5	-0.9	-0.4	0.5	-0.2	0.6	-1.3	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	3.3	-0.6	-0.4	-0.7	-0.9	-1.2	-0.5	1.8	-0.8	-0.0	-1.6
Medication: Ramipril	0.6	0.8	2.1	0.5	-0.5	-1.0	0.9	-0.3	1.4	1.2	0.7	0.9	0.7
Medication: Simvastatin	1.2	1.8	6.7	1.9	-2.6	-1.1	-0.3	-2.0	-0.7	-0.8	-0.5	-0.9	-0.3
Fluid intelligence score	0.7	1.5	6.9	-1.3	2.6	1.6	-1.2	0.1	-0.5	0.9	1.0	0.3	-0.6
Illnesses of siblings	0.6	0.8	3.5	-0.6	1.6	0.4	0.5	0.3	1.1	-0.1	1.9	0.2	-0.1
Neuroticism score	1.9	4.0	8.8	-2.1	3.0	2.0	2.0	-0.2	-2.7	-1.4	-0.1	-2.8	1.5
Weight	0.8	3.7	9.5	3.1	1.0	1.8	1.5	-2.0	-1.4	-2.0	-0.0	-2.8	1.8
Impedance of arm (right)	0.3	1.6	5.7	-1.6	-1.0	-0.1	1.9	-0.8	0.2	2.4	0.6	0.9	1.3
Arm fat percentage (right)	0.7	2.9	10.7	3.3	-0.5	0.8	1.6	-2.0	-0.5	-1.2	1.4	-1.5	2.3
Trunk fat-free mass	0.5	3.1	6.7	2.1	1.8	1.6	1.0	-0.9	-1.6	-2.6	-1.9	-2.4	0.5
Hip circumference	0.9	4.0	10.7	3.3	-0.2	1.4	1.7	-1.9	-1.4	-2.7	-0.2	-2.7	2.2
Time employed in main current job	3.1	3.6	9.9	0.1	-2.0	-2.0	-3.2	0.5	2.5	-0.1	-0.4	1.6	-3.0
Alcohol intake versus 10 years previously	1.9	2.8	10.6	1.5	1.7	0.6	1.5	0.7	-1.5	0.1	3.3	-1.1	2.3
Father’s age at death	0.6	0.8	1.9	-0.7	0.9	0.7	0.3	0.0	-1.2	-1.4	-1.2	-1.1	0.2
Worrier / anxious feelings	0.4	0.7	3.3	-0.9	1.8	0.9	0.2	0.5	-0.4	-0.5	-0.1	-1.1	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.6	-1.6	-0.2	-0.3	1.5	0.6	-1.1	-0.9	-0.2	-0.6	1.4
Falls in the last year	0.6	0.7	2.2	0.2	-0.8	-1.2	0.7	-0.7	-0.7	-1.5	-0.9	-0.8	-0.4
Hair/balding pattern: Pattern 3	0.3	0.5	1.6	-1.2	0.1	-0.1	-0.9	-0.2	-0.1	0.6	-0.0	0.9	-1.3
Number of live births	0.8	1.1	4.5	-0.8	0.3	1.2	2.1	-0.7	-0.3	-0.5	0.3	-1.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.5	1.7	4.6	-2.1	1.6	1.2	0.2	-1.2	-0.3	1.4	-1.7	-1.4	-0.2
Pulse rate	0.4	0.6	1.8	-0.2	-0.8	-0.1	1.3	0.3	1.4	-0.4	0.6	-0.1	1.1
Happiness	1.2	1.5	3.7	-1.2	0.6	1.4	1.8	1.7	-0.5	-0.9	0.8	0.2	1.9
Noisy workplace	0.6	0.7	2.9	0.3	-0.5	0.2	0.0	1.7	1.2	0.7	0.3	1.3	0.3
Qualifications: A levels/AS levels or equivalent	1.2	2.7	9.3	-3.0	1.0	-0.6	-1.0	2.1	0.3	2.0	-2.0	0.2	-1.7
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.8	-0.7	0.6	0.7	0.9	-0.8	0.0	1.5	0.6	1.7	0.2
Mouth/teeth dental problems: Dentures	0.6	1.0	3.7	0.7	-1.9	-1.2	0.4	0.5	1.4	0.7	-0.7	0.7	-1.0
Asthma	0.8	1.6	3.1	-0.8	1.3	-0.3	-1.1	1.8	1.5	0.8	1.0	1.5	-1.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.3	-1.1	-0.4	-0.0	-0.4	0.9	-0.3	0.1	0.3	0.0	-0.1
Medication: Cholesterol lowering	0.4	0.6	3.2	1.4	-1.8	0.4	-0.6	-0.4	-0.0	-0.1	-0.6	-0.5	0.0
Depression (self-reported)	0.3	0.4	1.6	-0.4	0.1	-0.2	0.7	0.3	0.4	-1.3	0.3	-1.1	0.2
Medication: Lansoprazole	0.3	0.3	0.9	0.7	0.4	-0.1	-0.9	-0.4	-0.1	0.3	0.5	1.0	0.0
Prospective memory result	1.1	1.3	4.8	2.2	-0.9	-0.5	-0.6	2.1	0.7	-0.4	0.1	1.3	-0.2
Lung cancer (father)	0.9	1.1	3.3	1.7	-1.4	-0.7	-0.7	0.8	1.8	-0.3	-0.5	-0.0	-0.7
Illnesses of mother	0.9	1.1	3.1	-1.6	-0.5	-0.3	0.8	0.4	-1.6	-1.8	-0.5	-0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.8	-1.1	1.9	1.2	0.3	-1.3	-0.1	0.2	-1.9	-1.5	0.1
Pulse wave Arterial Stiffness index	0.7	0.9	3.6	1.9	0.2	0.4	0.9	1.2	-1.0	-0.3	0.6	-0.5	1.0
Impedance of arm (left)	0.4	1.8	9.1	-1.6	-0.6	0.4	1.4	-1.0	0.2	3.0	0.7	1.1	1.2
Arm fat mass (right)	1.0	4.0	13.0	3.6	0.2	1.6	1.8	-2.1	-0.9	-2.1	0.7	-2.4	2.4
Trunk predicted mass	0.6	3.2	6.6	2.1	1.8	1.7	1.0	-0.9	-1.5	-2.6	-2.0	-2.4	0.5
Standing height	0.5	4.5	8.2	-0.2	2.0	2.3	2.6	-2.1	-2.6	-0.4	-2.8	-2.9	1.2
Length of working week for main job	0.5	0.6	1.7	0.4	0.1	1.1	-1.0	-0.1	1.3	-0.8	-1.1	0.3	0.1
Exposure to tobacco smoke at home	0.4	0.5	1.3	0.8	-0.8	0.3	0.8	-1.1	-0.8	0.3	-0.2	-0.9	0.1
Breastfed as a baby	0.6	0.7	3.4	0.6	0.3	0.9	0.0	-0.7	-0.7	-1.9	-0.9	-0.8	-0.1
Tense / ‘highly strung’	0.4	0.7	2.6	0.1	0.9	0.4	0.7	0.6	-0.9	-0.6	1.1	-1.6	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	3.2	-0.0	-0.4	0.1	1.8	0.7	-0.3	0.3	0.4	-0.5	1.6
Hair/balding pattern: Pattern 4	0.2	0.5	1.7	0.5	1.3	0.5	0.9	0.3	-0.7	0.8	0.7	-0.6	0.2
Birth weight of first child	0.4	0.7	4.8	0.3	2.2	1.2	-0.1	0.3	-0.3	-0.4	0.7	0.0	-0.4
Peak expiratory flow (PEF)	0.2	0.5	2.2	-1.0	1.5	-0.4	-0.7	0.1	-0.0	0.1	-0.6	-0.5	-0.9
Pulse wave reflection index	2.2	2.7	10.9	0.4	2.3	1.1	1.7	-0.7	-3.3	0.3	1.4	-1.5	1.2
Ever highly irritable/argumentative for 2 days	1.2	1.4	5.2	-0.0	2.0	2.3	-0.3	-1.3	-1.0	0.2	0.3	-1.5	-0.2
Loud music exposure frequency	1.4	1.6	3.3	0.3	1.8	1.8	1.2	-0.1	0.3	1.1	1.8	1.6	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	4.4	-1.7	0.7	-0.2	-1.2	2.1	0.7	1.0	-1.3	1.1	-0.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	7.8	0.6	1.7	2.8	0.5	-1.0	-0.0	0.6	-0.1	-1.1	0.2
Blood clot in the leg (DVT)	0.3	0.4	0.9	0.4	0.5	0.1	-0.7	0.8	0.7	0.9	-0.6	0.4	-0.5
Medication: Paracetamol	1.0	1.7	5.2	1.3	0.4	1.3	0.4	1.0	2.1	0.3	2.3	1.6	0.2
Headache pain in last month	0.6	1.0	3.3	1.2	-0.2	-0.3	1.8	-0.4	-0.9	-0.0	1.2	-0.4	1.7
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.6	-0.7	1.6	-0.6	-1.1	0.9	0.9	0.1	0.5	1.5	-0.9
Glaucoma (self-reported)	1.3	1.6	5.4	-1.3	-0.5	-0.9	-0.4	-1.1	-0.8	1.8	-1.5	-0.5	-2.3
Gout (self-reported)	0.5	0.7	2.6	-1.4	-1.6	-1.0	0.6	-0.6	-0.2	0.1	-0.6	-0.1	0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.8	0.7	1.7	0.6	-0.1	-0.8	-0.8	-0.3	1.2	-1.3	0.5
Medication: Amlodipine	0.3	0.4	1.5	-0.1	-0.5	-0.1	1.2	-0.3	-1.0	0.2	0.2	-0.2	0.8
Medication: Ventolin 100micrograms inhaler	0.7	0.9	3.1	-0.3	-0.6	-0.1	-0.9	1.0	1.8	0.2	0.1	1.7	-0.5
Birth weight	0.2	0.4	1.6	0.5	1.0	-0.1	0.4	0.0	0.1	0.5	1.3	0.4	0.6
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.8	0.3	-0.2	-0.4	0.9	0.2	-0.0	0.1	-0.9	-0.1	0.7
High blood pressure (siblings)	0.3	0.4	1.3	0.5	-0.4	-0.7	-1.1	0.3	0.2	0.6	-0.6	0.5	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	5.0	-0.7	1.8	1.4	-0.3	-0.9	0.5	0.5	-2.2	-0.5	-0.3
Body fat percentage	0.7	2.9	10.9	3.3	-0.5	1.2	1.5	-1.8	-0.2	-0.7	1.5	-1.5	2.3
Leg fat percentage (right)	0.8	2.8	13.5	3.7	-1.1	0.2	1.0	-1.2	0.5	-0.9	2.2	-0.9	1.9
Arm fat-free mass (right)	0.6	2.9	6.5	2.4	1.8	1.9	0.8	-0.7	-1.4	-2.3	-1.2	-2.5	0.6
Exposure to tobacco smoke outside home	0.8	1.1	2.5	1.3	0.0	1.5	1.6	-0.9	-0.9	-0.7	-0.6	-0.6	1.0
Comparative body size at age 10	0.3	0.8	4.4	-0.0	-0.8	0.4	-0.2	-2.1	0.5	1.3	0.5	-1.0	0.2
Number of full brothers	0.9	1.1	4.4	0.4	-2.1	1.5	-0.4	-1.2	-0.6	-0.1	1.1	0.2	1.1
Worry too long after embarrassment	1.3	2.1	6.1	-2.5	2.0	1.2	0.4	0.5	-2.1	-0.8	-0.9	-1.8	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	5.6	-0.4	-0.3	-0.6	2.4	1.9	-0.3	0.6	0.9	-0.4	1.4
Wheeze or whistling in the chest in last year	0.3	0.5	1.6	1.2	0.8	0.2	0.5	0.4	-0.0	-1.0	0.6	0.5	-0.4
Number of children fathered	0.5	0.5	1.3	1.0	-0.4	0.4	0.8	0.3	-0.6	-0.9	-0.7	-0.7	1.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	7.1	-1.2	1.7	-0.1	1.0	-1.7	-2.7	-0.5	0.0	-1.4	0.6
Age at first live birth	1.6	2.8	7.2	-2.7	2.2	0.6	-2.0	-0.7	-1.0	-0.5	-1.9	-0.9	-2.3
Pulse wave peak to peak time	0.7	0.8	4.1	-2.0	-0.2	-0.4	-0.7	-1.1	0.6	0.1	-1.0	0.2	-0.9
Health satisfaction	0.4	0.6	2.3	0.2	0.8	-0.1	-0.5	1.5	0.1	-0.4	0.4	0.8	-1.3
Shortness of breath walking on level ground	0.2	0.2	1.2	0.1	-0.5	-0.4	-0.5	1.1	0.3	-0.1	0.2	0.5	-0.4
Qualifications: College or University degree	0.9	2.9	11.4	-3.0	1.6	-0.5	-1.0	1.1	0.2	3.4	-0.6	1.5	-0.7
Eye problems/disorders: None of the above	1.4	1.6	6.5	-1.0	0.6	1.5	0.6	-0.8	-0.6	-1.5	-0.6	-1.2	2.6
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.8	0.9	-0.2	-0.2	-0.9	0.3	0.5	-0.4	-0.5	0.1	-1.7
Emphysema/chronic bronchitis	1.2	1.4	4.2	1.0	-2.0	0.3	-0.9	-0.1	1.6	-1.3	-1.0	1.2	-1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	4.3	-1.5	-0.5	-0.5	-0.1	-1.5	-2.1	-0.3	-2.0	-1.1	0.9
Neck or shoulder pain in last month	0.5	0.8	3.0	-1.7	0.8	-0.8	-0.7	-0.7	-0.0	1.1	0.3	0.4	-0.9
Medication: Blood pressure	0.7	1.2	4.4	0.7	-1.8	0.5	0.9	-2.1	-0.3	0.5	-0.6	-1.5	0.4
Angina (self-reported)	0.9	1.2	3.8	2.0	-1.5	-1.2	-1.1	0.5	1.3	0.0	-0.1	0.3	-0.7
Migraine (self-reported)	0.8	1.0	4.9	0.4	-1.1	0.6	2.2	-0.6	0.4	-0.4	0.3	-0.7	1.4
Medication: Ibuprofen	0.3	0.4	1.5	-1.2	0.2	0.6	-0.2	1.2	-0.4	0.2	0.2	0.0	0.2
Medication: Allopurinol	0.8	1.0	2.9	-1.7	-0.3	-0.3	0.3	-1.4	-1.5	-0.4	-0.9	-1.3	0.5
Medication: Omeprazole	1.1	1.3	3.5	1.2	0.4	0.9	0.6	0.7	1.9	-0.8	1.7	1.7	-0.1
Medication: Seretide 50 evohaler	0.4	0.5	1.7	-1.3	0.2	-0.2	0.1	1.3	0.2	0.2	0.2	0.8	-0.3
Mean time to correctly identify matches	0.6	1.1	4.4	1.0	2.1	1.5	-0.9	-0.2	0.6	0.7	1.1	0.6	-0.6
Heart disease (mother)	0.8	1.0	4.3	2.1	-0.6	0.7	-0.8	0.8	1.3	-0.3	1.2	0.5	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.2	-0.5	-0.7	0.3	0.8	-0.7	-0.2	0.1	-1.2	0.4	1.5
Whole body fat mass	0.9	3.7	13.5	3.7	0.4	2.0	1.7	-1.9	-0.7	-1.4	0.9	-2.1	2.3
Leg fat mass (right)	0.7	2.7	11.6	3.4	0.1	1.1	1.4	-1.2	-0.3	-1.3	1.7	-1.6	1.9
Arm predicted mass (right)	0.6	3.0	6.4	2.5	2.1	2.1	0.8	-0.6	-1.3	-2.2	-1.1	-2.3	0.6
Pulse rate, automated reading	0.2	0.7	1.5	0.4	-0.7	-0.4	0.8	0.4	0.8	0.8	1.2	1.0	1.1
Alcohol intake frequency.	0.7	1.5	3.5	1.5	-0.3	0.3	1.3	-0.4	-1.6	-0.4	1.7	-1.3	1.9
Comparative height size at age 10	0.3	1.4	4.5	-1.0	1.3	1.8	-0.4	-1.2	-0.9	0.3	-2.1	-0.6	-0.6
Number of full sisters	0.5	0.6	2.3	0.1	-1.0	-0.5	-0.2	-0.8	1.2	0.0	0.2	1.5	0.7
Suffer from ‘nerves’	1.4	2.1	8.4	-0.5	2.9	1.2	-0.6	-1.4	-1.8	0.1	-0.1	-2.0	-1.3
Overall health rating	0.5	1.0	3.6	0.6	-0.2	1.9	1.2	0.1	0.4	-0.6	0.8	-0.0	1.9
Chest pain or discomfort	1.4	2.1	5.7	0.9	-0.3	0.8	-1.8	2.0	1.8	0.7	-0.2	1.5	-2.4
Had major operations	0.4	0.4	1.8	1.3	-0.4	-1.4	-0.1	-0.2	-0.5	-0.2	-0.2	-0.5	0.1
Age at last live birth	1.9	2.8	7.3	-2.7	1.2	-0.1	-1.7	-0.8	-1.5	-0.5	-2.0	-2.3	-1.9
Family relationship satisfaction	1.1	1.4	5.8	-1.6	0.5	2.4	0.8	-0.5	-1.4	1.4	-0.5	0.1	0.5
Leg pain on walking	1.0	1.3	5.6	-0.5	0.2	-1.0	-0.1	1.2	0.8	2.4	1.1	1.3	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	4.4	-0.8	2.1	1.3	0.3	0.3	-1.0	0.1	-0.2	0.1	0.1
Commuting to job workplace: Car/motor vehicle	1.3	1.4	4.5	0.7	0.8	2.1	1.6	0.2	0.3	0.1	1.7	0.5	1.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	2.6	1.6	-0.1	-0.2	-1.1	0.6	0.6	-1.6	-0.9	-0.3	-0.5
Medication: Aspirin	1.0	1.3	3.5	0.8	-1.6	-1.9	-0.3	1.1	1.5	1.2	0.5	0.1	-1.1
Supplements: Vitamin C	0.8	1.0	2.9	1.1	1.2	0.1	-1.7	-1.0	0.2	-0.2	0.5	0.9	-1.5
Knee pain experienced in last month	0.7	1.1	2.7	0.4	-1.3	-1.7	-1.3	-0.2	1.1	-0.1	-0.1	1.1	-1.3
Hypertension (Self-reported)	0.3	0.9	4.5	0.7	-0.6	0.8	0.1	-2.1	-1.0	1.1	-0.2	-0.7	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.7	-1.0	1.1	1.0	-0.1	1.6	1.3	0.1	0.2	1.3	0.1
Illnesses of father: Heart disease	1.2	1.6	4.0	0.8	-1.2	-1.3	-1.9	0.2	0.6	1.6	1.3	0.1	-2.0
Illnesses of siblings: Diabetes	0.5	0.6	2.3	0.2	0.2	1.5	-0.6	-1.0	-0.9	0.5	-0.7	-0.7	-0.0
Smoking status: Previous	0.4	0.6	1.5	0.6	-0.7	-1.0	-1.2	-0.1	0.8	-0.3	-0.8	-0.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	8.3	0.2	1.8	2.4	1.4	-1.7	-2.9	-0.5	-2.3	-2.1	0.8
Whole body fat-free mass	0.6	3.5	6.4	2.4	2.2	2.2	1.1	-1.1	-1.5	-2.4	-1.4	-2.5	0.9
Leg fat-free mass (right)	0.7	4.0	8.1	2.3	2.9	2.6	1.3	-1.4	-1.6	-1.9	-0.7	-2.8	1.2
Arm fat percentage (left)	0.7	3.0	10.9	3.3	-0.1	1.2	1.5	-2.0	-0.3	-0.9	1.7	-1.4	2.3
Average weekly red wine intake	1.5	2.2	11.6	-0.6	-0.1	-0.1	-0.6	0.9	2.6	1.3	-0.4	3.4	-0.9
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.3	0.2	1.3	1.6	2.1	-0.6	-1.2	0.6	0.7	-1.2	1.7
Mood swings	1.1	2.0	4.7	-0.7	2.2	1.8	1.8	-0.2	-1.1	-1.1	0.6	-1.8	1.3
Loneliness, isolation	0.6	0.9	2.1	-0.4	0.3	0.9	1.4	-0.7	-0.7	-0.5	0.7	-1.3	1.5
Long-standing illness, disability or infirmity	0.3	0.4	1.2	0.3	-0.2	-0.5	0.9	-1.0	-0.2	-0.2	1.1	-0.6	0.9
Ever had bowel cancer screening	0.6	0.7	1.6	-0.9	-0.1	-1.0	-1.2	-0.2	0.0	0.1	-1.1	0.9	-1.3
Diabetes diagnosed by doctor	0.3	0.5	1.7	0.7	-0.7	-1.3	-0.4	-0.5	0.3	-0.9	-0.1	-1.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	4.4	-2.1	0.3	-0.6	-0.0	-0.2	0.0	1.1	0.3	-1.0	-0.1
Friendships satisfaction	1.0	1.3	3.4	-0.5	1.4	1.7	0.3	0.6	-1.6	1.9	1.0	-0.1	-0.1
Qualifications: nursing, teaching	2.5	3.8	15.8	-4.0	1.4	0.2	-1.9	1.1	0.8	3.0	-0.4	1.6	-1.6
Commuting to job workplace: Walk	1.4	1.5	4.0	-0.2	-1.2	-2.0	-1.1	0.1	0.6	1.6	0.7	1.2	-1.7
Eye problems/disorders: Cataract	0.5	0.6	3.7	1.9	-0.7	-0.4	-0.0	0.1	-0.6	0.4	0.6	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.5	-0.8	1.6	0.3	-1.3	0.3	-0.6	-0.2	1.3	0.4	-0.0
Medication for cholesterol	0.6	0.9	3.0	0.5	1.7	1.7	0.5	0.8	0.2	0.0	0.9	-0.1	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	5.1	1.4	0.7	1.1	2.3	0.8	-1.1	-0.7	1.1	-1.1	1.4
Back pain experienced in last month	1.3	1.9	5.2	1.8	-0.2	1.6	1.8	-0.5	0.3	0.3	2.3	0.3	2.0
Mineral and other dietary supplements	0.9	1.2	4.4	-1.0	-0.1	1.1	0.6	1.2	0.2	2.1	1.4	1.2	0.2
Breast cancer (self-reported)	0.6	0.7	3.0	-0.9	1.7	0.2	0.5	-1.1	-0.2	-0.4	1.0	-0.8	0.4
Asthma (self-reported)	0.7	1.4	3.0	-1.1	1.4	-0.4	-0.9	1.7	1.3	0.7	0.7	1.5	-1.5
Osteoporosis (self-reported)	0.8	0.9	4.2	0.3	-0.7	-0.3	0.3	0.9	1.0	1.3	0.2	2.1	0.8
Osteoarthritis (self-reported)	0.8	1.0	8.3	0.9	0.6	0.2	-0.4	0.0	0.4	-0.0	2.9	0.3	-0.7
Medication: Aspirin	0.8	1.1	2.8	1.5	-1.7	-1.2	0.2	1.0	1.4	0.9	0.7	0.0	-0.4
Medication: Gliclazide	0.4	0.5	1.6	0.3	0.2	-1.3	-0.3	1.0	0.6	-0.1	0.8	0.9	-0.1
Illnesses of father: None of the above (group 1)	1.0	1.2	4.6	2.1	-0.4	-0.4	-0.4	0.3	0.2	-1.6	-1.8	0.5	-0.7
Smoking status: Current	1.2	1.8	4.9	1.6	-2.2	-0.6	-0.2	1.4	2.1	-0.4	0.9	1.8	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	10.0	-0.7	3.2	0.6	0.2	-1.6	-0.7	0.4	-0.6	-0.9	-0.7
Whole body water mass	0.6	3.6	7.3	2.4	2.1	2.1	1.2	-1.1	-1.6	-2.5	-1.6	-2.7	0.9
Leg predicted mass (right)	0.8	4.1	8.0	2.3	2.8	2.6	1.4	-1.4	-1.7	-1.9	-0.7	-2.8	1.2
Arm fat mass (left)	0.9	3.7	11.6	3.4	0.4	1.6	1.7	-1.9	-0.9	-1.9	0.9	-2.3	2.4
Number of self-reported non-cancer illnesses	0.4	0.7	2.7	0.1	-1.6	-1.3	0.0	0.0	0.8	0.5	0.3	0.7	-1.0
Average weekly champagne plus white wine intake	0.6	0.8	4.3	0.8	0.2	0.2	-1.4	0.5	2.1	-0.1	0.3	0.9	-0.2
Miserableness	1.7	3.0	6.2	-1.0	1.4	1.6	2.4	-0.6	-2.3	-1.4	0.5	-2.1	2.5
Guilty feelings	2.0	3.0	5.1	-2.0	2.0	2.3	2.1	0.7	-1.1	-1.8	-0.2	-2.1	1.8
Wears glasses or contact lenses	0.9	1.1	4.4	-0.7	-1.7	-2.1	-0.8	1.0	0.1	-0.9	0.1	-0.2	-0.6
Ever taken oral contraceptive pill	1.2	1.4	6.0	-2.5	0.5	0.1	-0.0	1.7	-1.4	-0.9	1.2	-0.8	0.3
Hearing aid user	0.1	0.1	0.5	0.5	-0.1	0.2	-0.7	-0.3	-0.1	-0.4	0.7	0.1	0.1
Mother’s age at death	1.0	1.3	4.8	-0.5	-0.2	-1.9	1.1	0.2	-0.7	0.6	-2.2	-0.6	-1.3
Financial situation satisfaction	1.1	1.3	3.1	-1.8	0.1	0.4	1.7	1.2	-1.3	-0.6	1.0	-0.6	1.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	3.4	1.6	-0.7	-1.3	-0.8	0.8	1.3	0.8	1.2	1.8	-0.3
Commuting to job workplace: Public transport	0.7	0.9	3.7	0.5	-0.4	-0.9	-0.9	-0.6	-0.4	0.1	-1.6	0.3	-1.9
Eye problems/disorders: Glaucoma	0.9	1.1	4.2	-0.0	-0.4	-0.5	-0.6	-1.4	-0.5	1.2	-1.4	-0.2	-2.0
Medication: Blood pressure	0.4	0.7	2.8	0.1	-0.4	-1.1	-0.2	-0.6	-0.6	1.7	0.9	0.7	-0.7
Pain type(s) experienced in last month: Hip pain	1.9	2.4	10.9	-0.2	-3.3	-2.3	-0.7	0.8	1.0	1.4	0.8	1.3	-1.2
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.9	0.3	0.4	-1.0	-0.3	-1.1	-1.0	-1.3	-1.4	-1.2	-0.6
High cholesterol (Self-reported)	0.7	1.2	5.0	0.8	-1.9	-0.1	-0.7	-2.2	0.0	-0.1	-1.2	-0.5	-0.6
Medication: Bendroflumethiazide	0.2	0.3	1.0	-0.1	-0.6	-1.0	-0.2	-0.7	0.0	0.4	-0.0	0.7	-0.6
Medication: Paracetamol	1.2	1.8	5.8	0.5	-0.5	0.2	-0.0	1.2	2.2	1.2	2.4	2.0	-0.5
Medication: Lisinopril	0.6	0.8	2.8	-0.0	-0.9	-1.2	-1.5	-0.6	0.3	0.1	-0.2	0.5	-1.7
Medication: Atorvastatin	0.5	0.7	2.8	0.5	-0.8	0.2	-1.7	-1.2	-0.1	-0.3	0.0	-1.2	0.1
Illnesses of father: High blood pressure	1.1	1.4	5.3	-2.0	2.3	1.1	0.1	-0.3	-0.3	1.0	1.4	0.1	0.8
Alcohol drinker status: Never	1.0	1.2	4.5	-0.3	0.3	-0.0	-0.7	1.2	0.6	1.7	1.3	2.1	-0.3
Ever smoked	0.7	1.2	3.0	0.5	-1.1	-1.7	-1.0	0.3	0.3	-1.3	-1.1	-0.8	-1.6
Basal metabolic rate	0.7	3.8	7.7	2.6	2.0	2.3	1.5	-1.4	-1.6	-2.4	-1.1	-2.8	1.3
Leg fat percentage (left)	0.8	2.8	12.7	3.6	-0.9	0.4	1.0	-1.4	0.3	-1.1	2.2	-1.2	2.0
Arm fat-free mass (left)	0.7	3.3	8.1	2.3	1.4	1.8	1.0	-1.0	-1.5	-2.7	-1.6	-2.9	0.8
Number of operations (self-reported)	0.2	0.4	1.2	0.9	-0.6	-0.4	1.1	-0.4	-0.1	-0.7	0.1	-0.0	0.6
Average weekly beer plus cider intake	0.6	0.9	3.1	-0.3	1.6	0.9	0.3	-0.9	-1.8	0.3	0.5	-0.5	0.8
Irritability	1.0	1.7	5.4	-0.7	1.2	2.3	0.8	-0.9	-1.0	-1.1	-1.8	-1.4	0.7
Risk taking	0.3	0.5	2.1	-1.0	-0.1	-1.4	-0.6	0.3	-0.5	0.4	-0.7	0.2	-0.4
Ever had prostate specific antigen (PSA) test	1.3	1.4	3.6	1.1	-0.6	-1.9	-1.3	1.7	1.2	0.4	-0.3	1.1	-1.3
Fractured/broken bones in last 5 years	0.9	1.2	2.8	1.4	-0.6	-1.5	-1.2	0.9	0.1	-0.7	0.8	0.8	-1.7
Age started oral contraceptive pill	0.3	0.4	1.2	0.3	-0.7	0.2	0.7	0.8	0.3	-1.1	0.5	-0.0	0.6
Diastolic blood pressure, automated reading	0.2	0.7	1.8	1.3	0.3	1.3	0.4	-1.1	-1.1	0.6	-0.1	-0.7	0.4
Ever depressed for a whole week	0.2	0.2	0.8	-0.5	0.1	0.6	0.3	-0.1	-0.9	-0.1	0.6	-0.2	0.4
Unable to work because of sickness or disability	0.6	0.8	2.2	0.9	-1.5	-0.5	0.8	0.1	1.0	-1.2	1.1	-0.4	0.1
Commuting to job workplace: Cycle	0.7	0.8	2.9	-1.7	-0.6	-1.3	-0.9	-0.3	-0.6	0.7	-0.7	-0.3	-0.8
Myopia	0.5	0.7	1.8	-0.6	-1.1	-1.0	-1.2	0.6	-0.6	-0.3	-1.3	-0.2	-0.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.9	-1.5	1.9	-0.3	-0.4	2.0	1.2	-0.6	0.2	0.9	0.2
Cholesterol lowering medication	1.2	1.7	11.9	0.5	-0.4	-0.3	-0.5	-3.5	-1.3	-0.5	-0.5	-1.5	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	6.5	2.2	-0.0	1.1	-0.1	0.8	2.3	-1.0	1.9	2.5	-0.2
Pain experienced in last month	0.3	0.5	1.7	-0.8	0.6	0.7	-0.9	0.4	0.1	-1.3	-0.6	-0.3	-0.7
Supplements: Calcium	0.9	1.0	3.5	1.9	0.7	1.0	-0.3	0.7	1.4	-0.9	-0.0	1.2	-0.5
Basal cell carcinoma (self-reported)	0.6	0.7	1.6	0.3	1.1	0.1	0.5	0.4	-1.0	1.0	0.3	-1.3	1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	5.8	2.4	0.3	0.9	0.8	0.2	0.6	-0.7	0.9	-0.1	0.5
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	0.3	0.3	-0.1	-0.8	1.1	0.8	0.9	-0.7	0.5	-0.4
Heart disease (siblings)	2.1	2.5	11.4	2.9	-3.4	-0.2	-0.6	-1.3	-0.7	-0.7	-1.5	0.2	-0.1
Alcohol drinker status: Previous	1.2	1.4	4.9	-0.5	-0.6	-0.7	0.6	-1.1	-2.2	-0.7	-1.3	-2.0	-0.2
Pack years of smoking	1.0	1.5	9.6	3.1	-1.9	-0.3	0.4	0.4	0.5	-0.9	-0.3	0.3	0.6
Impedance of whole body	0.3	1.7	6.7	-1.9	-1.6	-0.2	1.3	-0.4	0.3	2.6	0.5	0.8	1.1
Leg fat mass (left)	0.8	3.0	11.8	3.4	0.1	1.4	1.5	-1.3	-0.3	-1.3	1.6	-1.8	2.1
Arm predicted mass (left)	0.7	3.4	8.8	2.4	1.2	1.6	1.1	-0.9	-1.5	-2.7	-1.6	-3.0	0.8