Hub : Genes

RGMB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.193	0.0580	7.4e-08	0.063	0.066	0.102	0.081	0.097	4.0e-08	1.9e-08	2.1e-12	4.2e-10	7.3e-12
2	GTEx	Esophagus Gastroesophageal Junction	0.248	0.0760	1.4e-04	0.143	NA	0.101	NA	0.119	7.7e-06	NA	1.7e-04	NA	4.6e-05
3	GTEx	Testis	0.231	0.0650	3.2e-05	0.152	NA	0.163	NA	0.190	2.9e-07	NA	1.0e-07	NA	7.5e-09
4	METSIM	Adipose	0.029	0.0130	9.2e-04	0.008	0.017	0.013	0.016	0.009	1.8e-02	1.0e-03	3.7e-03	1.4e-03	1.2e-02
5	ROSMAP	Brain Pre-frontal Cortex	0.130	0.0429	8.3e-08	0.055	0.077	0.099	0.082	0.096	1.1e-07	3.5e-10	1.2e-12	9.1e-11	2.6e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.0	1.5	4.2	1.6	-0.7	-2.0	-0.1	0.8
Bipolar Disorder or Schizophrenia	1.4	3.4	10.3	3.2	-2.1	-0.4	0.7	1.3
Depressed Affect (Nagel 2018)	0.4	0.8	1.3	-0.9	1.0	-0.2	1.1	1.0
Depression (Nagel 2018)	0.3	0.4	1.5	0.1	-0.3	0.2	1.2	0.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	2.7	1.0	0.8	-1.6	0.3	0.9
Neuroticism (Nagel 2018)	0.3	0.7	1.6	-0.2	1.1	-1.3	0.4	0.8
Schizophrenia (2018)	1.6	3.2	8.1	2.8	-2.1	1.2	1.0	1.1
Schizophrenia vs Biploar Disorder	2.1	2.8	5.7	2.4	-0.5	1.5	1.6	1.9
Worry (Nagel 2018)	0.3	0.5	1.1	0.6	1.1	-0.4	-0.9	0.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.1	0.7	0.7	-0.3	0.4	1.0
Alzheimer’s Disease (in father)	1.8	1.9	3.6	-0.8	-1.9	1.1	-1.3	-1.5
Alzheimer’s Disease (including proxy)	0.6	0.9	2.1	-0.1	-1.4	1.2	-0.9	-0.6
Crohns Disease (2017)	0.5	1.1	1.9	-1.4	1.1	1.0	1.1	-0.1
Irritable Bowel Disease (IBD)	1.0	2.5	4.2	-2.0	-0.9	2.0	1.6	-1.0
Ulcerative Colitis (UC)	1.6	3.0	4.7	-2.0	-2.2	1.8	1.3	-1.2
Major Depression (MDD)	0.2	0.3	0.9	0.1	-0.6	0.9	0.2	0.1
Reaction Time	1.2	2.2	8.4	-0.5	2.9	0.1	-1.1	-1.1
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.8	0.5	0.8	-0.6	0.9	0.8
Breast Cancer	1.0	2.4	4.5	2.1	-0.0	-1.9	0.7	1.9
Ovarian Cancer	0.5	0.6	1.5	0.9	-0.4	0.8	0.4	1.2
Prostate Cancer	0.1	0.1	0.2	0.1	-0.2	-0.5	-0.1	0.4
Age at First Birth	1.2	1.7	3.1	1.5	1.6	-1.0	-1.8	0.0
Bipolar Disorder (2011)	1.6	1.5	2.6	1.5	0.5	-0.6	1.5	1.6
Body Mass Index (BMI) (2010)	1.6	2.2	7.5	1.0	-0.9	2.7	1.0	0.9
Coronary Artery Disease (CAD)	0.6	0.7	1.0	0.8	-0.3	1.0	1.0	0.9
Crohns Disease (2012)	0.5	0.9	2.8	-0.7	1.7	-0.1	0.3	0.9
Mean Putamen Volume	0.3	0.3	0.7	-0.5	0.2	-0.7	0.4	-0.8
Fasting Glucose	0.1	0.1	0.4	-0.6	-0.0	-0.0	-0.3	-0.4
HbA1C	1.6	1.7	3.5	1.9	0.6	0.7	1.1	1.7
HDL Cholesterol	0.1	0.2	0.5	0.0	0.7	0.4	-0.3	0.2
LDL Cholesterol	0.2	0.3	0.7	0.6	0.0	0.8	0.4	-0.2
Lupus	0.3	0.5	0.8	-0.9	-0.7	0.8	0.4	0.5
Neuroticism (2016)	0.4	0.6	2.3	0.6	-1.5	0.0	-0.5	0.1
Primary Biliary Cirrhosis	0.5	0.8	1.5	0.8	-0.6	1.2	0.9	0.6
Rheumatoid Arthritis	0.1	0.2	0.4	0.1	-0.6	0.5	-0.0	0.5
Schizophrenia (2014)	1.4	3.1	8.0	2.8	-2.0	1.0	1.0	1.2
Triglycerides	1.5	2.4	6.3	2.5	-0.3	-0.2	1.8	1.4
Type 2 Diabetes (T2D) (2012)	2.9	3.3	6.1	2.4	0.1	-2.5	0.4	2.2
Ulcerative Colitis	2.0	2.9	4.5	-1.6	-2.1	2.0	1.1	-1.4
Blood Eosinophil Count	1.8	13.7	24.8	4.8	0.7	2.9	5.0	3.4
Blood Platelet Count	0.3	3.8	8.5	-0.2	2.9	-2.9	-1.2	-0.9
Blood Red Count	0.6	5.9	10.6	-2.2	-3.3	1.9	-1.9	-2.6
Blood White Count	0.1	0.4	0.5	0.4	0.7	-0.7	-0.7	-0.6
Heel T-Score	1.0	8.1	22.7	1.4	-4.8	3.6	1.6	-0.5
BMI	0.4	2.3	5.0	1.0	-0.2	2.1	2.2	0.8
Height	0.2	3.9	15.9	0.3	-4.0	0.7	1.3	1.1
Waist Hip Ratio (WHR)	0.5	2.3	5.9	0.0	2.4	-1.9	-0.9	0.9
Systolic Blood Pressure	0.8	4.2	9.7	1.8	1.6	-3.1	1.7	1.7
Smoking Status	0.5	1.1	3.6	-0.9	1.9	-1.0	0.2	0.2
Allergy or Eczema	1.0	2.7	4.9	-2.2	-1.1	1.0	-1.6	-2.0
Cardiovascular Disease	0.5	1.8	3.7	1.9	0.3	-1.3	1.2	1.4
Hypothyroidism (self reported)	1.4	3.3	8.9	1.3	3.0	-2.0	0.9	1.0
Respiratory disease	4.9	10.8	19.3	-4.2	1.3	-0.3	-4.4	-3.9
Type 2 Diabetes (T2D) (2018)	2.4	4.5	10.3	2.5	0.6	0.1	2.3	3.2
Lung FEV1/FVC ratio	3.7	18.5	34.5	4.6	-3.7	3.5	5.9	3.4
Lung FVC	1.4	7.0	11.2	3.3	-1.8	2.8	2.3	2.8
Neuroticism	0.2	0.6	1.3	-0.5	0.6	-1.1	-1.1	0.3
Chronotype (morning person)	1.8	4.2	11.3	-0.1	-3.1	3.4	-0.0	-0.5
Hair Pigment	0.2	5.3	9.7	-2.8	-2.8	-0.6	-1.0	-3.1
Tanning	0.2	2.6	4.0	-0.6	-1.8	1.7	-2.0	-1.6
Hand grip strength (left)	1.4	3.7	5.1	-1.3	-1.7	2.1	-2.1	-2.2
Number of treatments/medications taken	0.1	0.2	0.4	0.2	0.7	-0.2	-0.1	0.7
Average weekly spirits intake	0.3	0.3	1.0	-0.4	0.6	1.0	-0.1	0.2
Sensitivity / hurt feelings	1.1	1.8	6.7	0.4	1.4	-2.6	0.2	0.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.3	-0.0	1.1	-0.2	0.6	0.7
Hearing difficulty/problems: Yes	0.5	0.8	2.8	-0.8	-1.7	0.0	-0.5	0.4
Relative age of first facial hair	1.9	3.8	6.3	-2.0	1.1	-2.2	-2.5	-1.7
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.7	-0.6	-0.5	-0.8	0.2	0.0
Ever used hormone-replacement therapy (HRT)	1.1	1.4	3.5	0.2	-0.8	1.5	1.9	0.7
Ever had hysterectomy (womb removed)	2.0	2.2	11.0	-0.3	-3.3	0.1	-0.1	-0.1
Systolic blood pressure, automated reading	0.4	1.2	3.0	0.7	0.8	-1.7	0.9	0.9
Eye problems/disorders: Diabetes related eye disease	3.5	3.8	11.7	1.8	1.2	-0.0	1.6	3.4
Angina	1.4	1.9	4.4	0.4	-1.6	2.1	1.5	0.2
Medication for hormone replacement therapy	1.2	1.4	3.1	1.8	-0.1	0.8	0.6	1.6
Vitamin and mineral supplements	0.6	0.8	2.1	-0.3	-1.5	1.1	0.7	-0.5
Supplements: Zinc	0.6	0.6	1.9	0.3	1.4	0.5	-0.7	0.7
Medication: Co-codamol	0.1	0.2	0.4	0.5	-0.6	-0.1	-0.4	-0.0
Medication: Metformin	4.0	5.6	12.8	2.3	0.7	-0.9	2.9	3.6
Diabetes (father)	1.2	1.5	3.0	1.4	-1.0	0.7	1.2	1.7
Diabetes (mother)	1.8	2.3	5.0	2.0	1.6	0.0	0.4	2.2
Severe depression (siblings)	1.1	1.2	4.3	-0.2	0.3	2.1	1.0	0.9
Pack years adult smoking proportion	1.4	2.2	4.6	-2.1	-0.8	0.1	-1.1	-2.1
Impedance of leg (right)	2.1	9.9	32.1	-1.4	-1.7	-1.7	-5.7	-3.1
Leg fat-free mass (left)	0.8	4.4	12.4	0.3	-0.8	2.6	3.5	1.6
Trunk fat percentage	0.2	0.8	1.9	0.4	0.0	-0.8	1.4	1.2
Hand grip strength (right)	1.1	3.1	5.8	-1.1	-1.8	2.4	-1.9	-1.3
Townsend deprivation index at recruitment	1.1	1.6	4.1	-1.6	-0.8	0.8	-0.0	-2.0
Current tobacco smoking	0.4	0.6	0.8	-0.9	0.7	-0.8	-0.7	-0.9
Average weekly fortified wine intake	0.5	0.6	1.3	0.3	-1.2	1.1	-0.4	-0.5
Maternal smoking around birth	0.2	0.3	1.0	-0.3	-1.0	0.4	-0.3	0.0
Fed-up feelings	0.5	0.9	2.1	-1.5	1.2	-0.4	0.8	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.8	0.2	0.2	-0.2	1.4	0.5
Relative age voice broke	1.6	2.4	5.0	-0.3	2.2	-2.2	-1.3	0.0
Taking other prescription medications	0.1	0.1	0.2	0.1	-0.0	0.4	0.2	0.5
Age when periods started (menarche)	0.4	0.9	1.9	0.1	0.4	-1.2	-1.4	-0.9
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.9	-0.4	-2.2	0.7	1.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.0	1.7	-1.5	1.2	1.7	1.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	2.6	0.1	-0.1	-1.6	-0.9	0.3
Qualifications: CSEs or equivalent	1.3	1.8	5.3	-0.8	-0.5	-2.3	-1.3	-1.0
Serious illness, injury or assault to yourself	0.4	0.4	0.7	-0.3	-0.8	-0.5	0.8	0.7
High blood pressure	1.0	2.7	9.1	1.0	1.5	-3.0	0.8	0.8
Hayfever, allergic rhinitis or eczema	1.5	3.2	6.2	-2.0	-0.9	1.0	-1.9	-2.5
Multivitamins +/- minerals	0.7	1.0	3.7	-0.1	1.9	-0.5	0.1	0.9
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.1	0.5	-0.1	-0.2	0.1
Supplements: Glucosamine	0.7	0.9	3.2	0.1	1.8	-0.8	0.3	0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.8	0.3	-0.6	-0.5	0.0
Medication: Atenolol	2.8	3.5	7.8	2.8	-0.8	0.1	2.0	2.2
Medication: Levothyroxine sodium	1.2	2.0	4.8	0.8	1.1	-2.2	1.8	0.5
Sitting height	0.1	0.7	1.9	-1.4	-0.7	-1.0	0.5	-0.1
Chronic bronchitis/emphysema (father)	0.5	0.6	2.0	0.0	-0.6	0.7	-1.4	-0.6
High blood pressure (mother)	0.1	0.2	0.3	-0.5	0.4	0.3	0.5	0.4
Body mass index (BMI)	0.5	2.0	5.7	0.3	-0.6	1.7	2.4	1.0
Impedance of leg (left)	2.0	9.5	29.1	-1.4	-1.2	-2.5	-5.4	-3.0
Leg predicted mass (left)	0.8	4.2	11.2	0.2	-0.8	2.6	3.4	1.5
Trunk fat mass	0.3	1.4	4.6	0.4	-0.6	0.4	2.1	1.4
Waist circumference	0.2	0.9	2.7	0.3	-0.1	0.9	1.6	1.0
Number of incorrect matches in round	0.1	0.2	0.6	-0.2	0.8	0.3	-0.3	0.1
Past tobacco smoking	1.3	2.4	5.2	-1.0	-1.8	1.3	-0.7	-2.3
Alcohol usually taken with meals	0.4	0.6	1.8	1.3	-0.7	-0.5	0.4	0.4
Nervous feelings	0.8	1.6	3.8	1.9	1.0	-0.6	0.7	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.7	0.7	0.2	0.3	0.9	0.3
Hearing difficulty/problems with background noise	0.3	0.5	0.7	0.8	-0.9	0.2	-0.5	0.8
Hair/balding pattern: Pattern 2	0.1	0.1	0.5	-0.1	0.1	0.0	0.7	0.2
Had menopause	0.9	1.1	2.3	-0.9	-0.9	1.5	1.1	0.7
Had other major operations	0.3	0.4	0.7	-0.8	-0.8	0.3	0.7	0.3
Forced vital capacity (FVC)	0.8	3.1	4.8	2.2	-0.6	1.8	2.0	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	6.5	1.8	-2.5	2.4	1.4	0.6
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.7	0.0	0.3	0.8	1.6	1.6
Qualifications: None of the above	0.6	1.4	2.7	-0.9	-0.4	1.3	-1.7	-1.2
Financial difficulties in last 2 years	0.5	0.6	1.3	0.4	0.6	-1.1	1.2	0.4
Mouth/teeth dental problems	0.7	1.0	2.9	1.2	0.8	-0.3	-0.2	1.7
Heart attack	1.9	2.4	6.7	0.2	-2.2	2.6	0.2	-0.6
Allergy	2.1	4.8	8.5	2.9	0.8	-0.8	2.6	2.8
Pain all over the body in last month	0.5	0.5	1.7	-0.6	0.5	-0.2	-1.3	0.2
Diabetes (self-reported)	2.1	3.3	9.1	1.5	0.8	-0.7	2.0	3.0
Hayfever/allergic rhinitis (self-reported)	1.0	1.4	3.1	-1.3	-0.2	0.2	-1.8	-1.4
Medication: Ramipril	1.0	1.3	3.3	1.1	0.5	0.6	1.1	1.8
Medication: Simvastatin	1.7	2.5	6.4	1.5	0.0	0.3	2.5	2.0
Fluid intelligence score	0.4	0.9	2.7	0.3	1.2	-1.6	0.3	0.3
Illnesses of siblings	0.7	1.0	4.1	0.0	-0.5	0.8	-2.0	-0.2
Neuroticism score	0.4	0.9	1.9	-0.5	1.4	-1.1	-1.0	0.1
Weight	0.6	2.8	7.0	0.1	-1.3	2.0	2.6	1.1
Impedance of arm (right)	1.3	5.9	21.0	1.7	1.3	-4.6	-1.5	1.3
Arm fat percentage (right)	0.6	2.3	4.6	1.3	0.6	-0.6	2.1	2.2
Trunk fat-free mass	0.9	5.4	16.3	-0.1	-2.3	4.0	2.3	0.6
Hip circumference	0.8	3.4	7.0	0.1	-2.1	2.6	2.3	0.4
Time employed in main current job	0.3	0.4	1.1	0.8	-1.1	0.3	-0.1	0.2
Alcohol intake versus 10 years previously	0.5	0.8	1.7	1.1	1.3	-0.6	0.5	0.7
Father’s age at death	0.3	0.3	1.1	-1.1	-0.1	0.7	-0.2	0.2
Worrier / anxious feelings	0.7	1.3	1.9	-1.4	1.0	-0.8	-1.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	3.8	-1.8	-1.6	-0.0	-0.6	-1.9
Falls in the last year	0.4	0.5	1.2	-0.4	0.4	0.3	1.1	1.0
Hair/balding pattern: Pattern 3	0.3	0.4	1.5	1.2	0.3	0.4	-0.3	0.6
Number of live births	0.9	1.3	2.4	-1.2	-1.0	1.6	1.3	-0.1
Forced expiratory volume in 1-second (FEV1)	1.7	5.8	8.6	2.6	-2.0	2.9	2.7	1.5
Pulse rate	1.7	2.9	6.9	-1.0	-1.1	-0.4	-2.4	-2.6
Happiness	3.1	3.8	7.3	1.5	1.7	0.5	2.6	2.7
Noisy workplace	1.9	2.3	4.5	-2.1	-0.4	-1.2	-2.0	-1.1
Qualifications: A levels/AS levels or equivalent	1.1	2.5	4.9	1.6	2.2	-1.2	0.4	1.7
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.1	-1.2	-0.3	1.5	-0.8	-0.4
Mouth/teeth dental problems: Dentures	0.6	1.1	2.4	-1.5	-0.4	-0.8	-0.2	-1.5
Asthma	2.4	4.8	8.8	-3.0	0.9	-0.0	-2.8	-2.6
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.5	10.8	-0.7	-3.3	3.2	-0.6	-0.9
Medication: Cholesterol lowering	0.5	0.8	1.8	0.4	-0.5	0.6	1.3	1.3
Depression (self-reported)	0.2	0.2	0.9	0.1	0.2	-0.9	0.2	0.3
Medication: Lansoprazole	2.6	2.9	7.6	2.8	-0.7	-0.6	1.0	2.2
Prospective memory result	1.5	1.9	3.7	-1.4	-1.2	0.7	-1.9	-1.4
Lung cancer (father)	0.9	1.1	3.1	-0.4	0.2	-1.8	-1.1	-0.9
Illnesses of mother	0.6	0.7	1.9	-0.8	-0.0	0.4	-0.9	-1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.0	10.2	2.5	-1.9	3.2	2.8	1.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.6	0.3	0.4	-1.6	0.4	-0.0
Impedance of arm (left)	0.7	3.5	13.3	1.2	0.3	-3.6	-1.4	0.7
Arm fat mass (right)	0.5	1.9	5.6	0.6	-0.6	0.9	2.4	1.5
Trunk predicted mass	1.0	5.5	16.6	-0.1	-2.3	4.1	2.3	0.6
Standing height	0.2	1.5	5.0	-0.3	-2.2	1.3	0.9	0.4
Length of working week for main job	0.2	0.2	0.5	0.7	-0.4	0.5	0.0	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.6	-0.3	0.8	-0.0	0.5	0.2
Breastfed as a baby	1.8	2.2	5.7	-2.4	-0.4	1.7	-0.1	-1.5
Tense / ‘highly strung’	0.7	1.1	3.1	1.1	1.8	-0.1	0.4	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	2.9	0.8	0.9	0.1	0.7	1.7
Hair/balding pattern: Pattern 4	0.8	2.0	6.9	-1.5	0.3	0.1	-0.8	-2.6
Birth weight of first child	0.2	0.3	1.3	0.0	0.2	0.0	1.2	0.1
Peak expiratory flow (PEF)	0.6	1.4	2.9	1.0	-1.7	1.5	0.7	0.8
Pulse wave reflection index	1.1	1.4	4.7	0.0	1.1	-0.7	2.2	0.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.1	0.2	0.5	-0.6	1.0	0.2
Loud music exposure frequency	0.3	0.3	0.5	0.2	0.7	-0.4	-0.7	-0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.9	2.2	1.5	0.2	-0.4	0.7	1.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.2	0.6	-0.4	0.5	1.1	0.2
Blood clot in the leg (DVT)	0.7	0.9	1.2	-0.9	-1.1	1.0	1.0	0.7
Medication: Paracetamol	2.0	3.4	6.3	-2.1	-1.3	0.9	-2.5	-1.9
Headache pain in last month	0.3	0.6	2.0	-1.4	0.1	-0.2	-0.7	-0.7
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.3	-0.9	-0.0	-0.2	-1.8	-1.2
Glaucoma (self-reported)	1.6	1.9	4.3	-2.1	0.1	0.2	-1.2	-1.9
Gout (self-reported)	1.0	1.4	2.5	-1.5	1.2	0.2	-0.9	-1.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	0.3	1.0	-1.1	0.7	-0.1
Medication: Amlodipine	2.8	4.0	5.4	2.3	2.0	-2.3	1.3	1.8
Medication: Ventolin 100micrograms inhaler	5.8	7.5	14.0	-3.7	0.8	-0.5	-3.4	-3.3
Birth weight	0.9	2.0	4.0	-1.8	-0.6	2.0	-0.4	-1.4
Chronic bronchitis/emphysema (mother)	2.2	2.6	6.5	0.1	1.8	-2.5	1.0	1.4
High blood pressure (siblings)	0.9	1.3	5.9	0.3	-0.8	-0.1	2.4	0.3
Forced vital capacity (FVC), Best measure	0.7	2.4	7.2	1.1	-1.0	2.7	1.4	0.9
Body fat percentage	0.1	0.4	1.0	0.0	-0.1	-0.3	1.0	0.8
Leg fat percentage (right)	0.1	0.5	1.6	-0.4	-1.2	0.6	-0.3	-0.4
Arm fat-free mass (right)	1.3	6.9	20.6	-1.3	-2.7	4.5	2.1	-0.4
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-1.0	0.0	0.7	0.8	-0.2
Comparative body size at age 10	2.7	7.5	13.3	2.5	2.0	-0.6	3.6	3.6
Number of full brothers	0.9	1.2	2.8	1.0	-0.9	-0.1	1.7	1.2
Worry too long after embarrassment	0.4	0.6	2.1	1.4	0.0	-0.5	-0.6	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.8	-0.2	-0.2	0.9	0.5	-0.3
Wheeze or whistling in the chest in last year	2.8	5.0	9.6	-3.1	-0.7	0.0	-2.8	-2.6
Number of children fathered	0.4	0.5	1.2	0.6	-0.2	-1.1	0.9	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.7	-0.5	-1.2	1.9	-0.6	-0.5
Age at first live birth	0.6	1.1	2.3	-0.1	0.2	-1.5	-1.3	-1.2
Pulse wave peak to peak time	0.6	0.7	2.6	-0.2	-0.8	1.6	-0.2	0.1
Health satisfaction	0.8	1.1	1.8	1.1	0.8	-0.5	1.4	1.2
Shortness of breath walking on level ground	0.3	0.3	0.6	-0.3	-0.8	-0.8	-0.1	-0.6
Qualifications: College or University degree	1.2	3.8	5.5	2.2	2.3	-2.0	0.7	2.1
Eye problems/disorders: None of the above	0.3	0.3	0.4	0.5	0.5	-0.6	-0.6	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.5	-0.6	-0.1	0.7	0.5	-0.0
Emphysema/chronic bronchitis	3.8	4.3	11.7	-1.7	1.2	-1.5	-3.4	-1.8
Medication for pain relief, constipation, heartburn	2.7	4.6	11.1	1.6	2.7	-3.3	0.8	1.1
Neck or shoulder pain in last month	0.4	0.6	1.7	-0.4	-1.3	1.0	0.3	-0.1
Medication: Blood pressure	1.1	1.9	3.2	1.8	0.6	0.1	1.8	1.7
Angina (self-reported)	1.6	2.1	4.8	0.5	-1.6	2.2	1.7	0.3
Migraine (self-reported)	0.9	1.1	3.3	-1.8	1.4	0.3	-0.3	-0.6
Medication: Ibuprofen	3.3	4.0	12.2	-0.6	-2.7	3.5	0.1	-0.0
Medication: Allopurinol	0.2	0.3	0.5	-0.2	0.7	0.7	-0.2	-0.6
Medication: Omeprazole	2.8	3.4	9.7	-0.4	-2.4	3.1	0.2	-1.2
Medication: Seretide 50 evohaler	2.2	2.5	7.5	-2.7	0.8	-0.7	-1.2	-1.6
Mean time to correctly identify matches	0.8	1.5	4.1	-1.1	2.0	0.4	-1.0	-1.0
Heart disease (mother)	0.2	0.3	0.9	-0.5	0.3	0.1	1.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.9	-0.4	2.0	-1.6	-0.8	-0.4
Whole body fat mass	0.2	1.0	2.8	-0.1	-0.9	0.7	1.7	0.7
Leg fat mass (right)	0.3	1.0	2.0	-0.5	-1.4	1.4	0.9	0.1
Arm predicted mass (right)	1.1	5.8	18.2	-1.3	-2.2	4.3	2.1	-0.3
Pulse rate, automated reading	2.1	6.7	15.5	-2.4	0.0	-1.8	-3.9	-3.0
Alcohol intake frequency.	0.1	0.3	0.9	0.5	-0.3	-0.9	-0.6	-0.1
Comparative height size at age 10	0.5	2.9	8.2	-1.0	-2.9	2.1	0.8	-0.6
Number of full sisters	0.2	0.3	0.8	-0.9	-0.5	-0.5	-0.3	-0.4
Suffer from ‘nerves’	0.3	0.4	1.8	1.4	0.0	-0.0	-0.0	0.5
Overall health rating	0.4	0.9	3.4	-0.3	-0.8	0.0	1.9	0.4
Chest pain or discomfort	1.0	1.4	5.6	-0.2	-2.4	0.6	0.8	0.5
Had major operations	0.7	0.8	1.4	-1.2	-0.6	0.2	-1.0	-1.1
Age at last live birth	0.6	0.9	2.3	-0.7	0.3	-0.8	-0.9	-1.5
Family relationship satisfaction	0.4	0.5	1.0	0.4	0.7	0.5	0.8	1.0
Leg pain on walking	0.6	0.8	2.3	1.1	-1.5	-0.2	0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	2.3	-1.5	0.5	-0.9	0.9	-0.5
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.7	-0.9	-1.6	1.1	-1.3	-0.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.3	2.7	1.6	0.6	-1.4	0.4	1.1
Medication: Aspirin	1.9	2.5	5.3	1.1	0.3	1.8	2.3	1.6
Supplements: Vitamin C	0.2	0.3	0.6	-0.3	0.2	-0.2	-0.8	-0.8
Knee pain experienced in last month	0.5	0.8	1.7	0.7	-0.3	-1.3	1.2	0.6
Hypertension (Self-reported)	0.9	2.4	6.6	1.2	1.5	-2.6	0.8	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.9	0.8	-1.0	1.7	0.6	0.3
Illnesses of father: Heart disease	0.1	0.1	0.4	-0.2	-0.0	-0.2	0.7	-0.2
Illnesses of siblings: Diabetes	0.3	0.4	1.0	-0.6	0.2	0.1	-1.0	-0.7
Smoking status: Previous	1.1	1.7	4.6	1.4	0.9	-0.6	0.8	2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.5	1.8	0.5	-1.3	0.2	-0.2	-0.3
Whole body fat-free mass	0.8	4.8	12.7	-0.2	-1.8	3.6	2.7	0.8
Leg fat-free mass (right)	0.8	4.2	13.6	0.3	-0.5	2.2	3.7	1.6
Arm fat percentage (left)	0.5	2.1	5.4	1.1	0.2	-0.1	2.3	1.9
Average weekly red wine intake	1.0	1.5	3.4	0.8	-1.2	0.7	1.8	1.3
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.0	1.4	-0.5	0.2	-0.1	0.9
Mood swings	0.6	1.1	3.1	-1.3	1.8	-0.8	-0.4	-0.1
Loneliness, isolation	0.5	0.7	1.8	0.7	1.4	-1.0	0.3	0.4
Long-standing illness, disability or infirmity	1.2	1.8	3.4	1.2	0.8	-1.3	1.3	1.8
Ever had bowel cancer screening	0.4	0.4	0.6	-0.8	0.0	0.7	-0.7	-0.7
Diabetes diagnosed by doctor	2.5	4.1	11.4	2.0	0.6	-0.2	2.2	3.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	0.5	0.4	0.4	0.5	0.9
Friendships satisfaction	2.4	3.0	5.0	2.0	-0.3	1.1	2.1	2.2
Qualifications: nursing, teaching	0.3	0.4	0.8	0.9	0.1	-0.7	-0.6	0.7
Commuting to job workplace: Walk	0.4	0.4	0.8	-0.3	0.6	-0.9	0.6	-0.7
Eye problems/disorders: Cataract	0.6	0.7	1.2	-1.1	-1.0	0.7	0.8	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	3.5	-1.5	-0.8	-0.1	-1.9	-1.8
Medication for cholesterol	1.6	2.4	4.7	-2.1	-0.5	-0.5	-2.2	-1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.6	0.5	-0.6	-0.7	0.6	0.6
Back pain experienced in last month	0.7	1.0	1.7	1.2	0.5	-0.2	1.2	1.3
Mineral and other dietary supplements	0.6	0.9	2.3	-0.2	-1.5	0.7	-0.3	-1.2
Breast cancer (self-reported)	0.4	0.4	0.9	-0.7	-0.4	-0.7	0.9	0.5
Asthma (self-reported)	2.7	5.4	11.0	-3.3	0.9	-0.1	-2.8	-2.8
Osteoporosis (self-reported)	1.9	2.3	8.0	-1.3	-2.8	1.2	-0.1	-0.9
Osteoarthritis (self-reported)	0.1	0.1	0.3	0.5	-0.3	0.3	0.2	-0.2
Medication: Aspirin	1.8	2.3	5.0	0.8	-0.1	2.1	2.2	1.2
Medication: Gliclazide	2.5	2.8	6.1	-0.4	1.7	-2.5	1.4	1.7
Illnesses of father: None of the above (group 1)	1.1	1.4	4.7	-0.5	1.0	-2.2	-0.9	-0.3
Smoking status: Current	0.4	0.7	1.0	-1.0	1.0	-0.8	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.3	8.1	2.8	-1.6	2.8	2.2	1.9
Whole body water mass	0.8	4.7	12.2	-0.1	-1.7	3.5	2.8	0.9
Leg predicted mass (right)	0.8	4.4	14.3	0.3	-0.5	2.2	3.8	1.7
Arm fat mass (left)	0.5	1.9	5.7	0.6	-0.7	1.1	2.4	1.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.7	-0.8	0.1	-0.6	0.0	0.1
Average weekly champagne plus white wine intake	0.3	0.4	1.3	-0.5	-0.6	-0.4	0.3	-1.1
Miserableness	0.4	0.7	1.6	-1.2	1.3	-0.4	-0.5	-0.4
Guilty feelings	0.3	0.5	1.6	-0.4	1.3	-0.2	-0.4	-0.6
Wears glasses or contact lenses	0.6	0.7	1.2	1.0	-0.1	0.4	1.1	1.0
Ever taken oral contraceptive pill	1.4	1.6	3.0	-0.8	0.4	-1.6	-1.2	-1.7
Hearing aid user	0.5	0.5	2.0	-0.1	-1.4	0.4	0.6	-0.3
Mother’s age at death	0.3	0.3	1.0	0.1	-0.7	0.5	-1.0	0.0
Financial situation satisfaction	1.3	1.6	2.9	-1.5	0.6	-0.7	-1.7	-1.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.2	-0.8	0.0	-0.5	-0.9	-1.1
Commuting to job workplace: Public transport	0.2	0.3	0.9	-0.1	0.2	1.0	0.6	-0.3
Eye problems/disorders: Glaucoma	1.6	1.8	4.8	-2.2	-0.0	1.0	-0.2	-1.9
Medication: Blood pressure	2.4	4.5	6.5	1.9	1.9	-2.1	2.5	2.0
Pain type(s) experienced in last month: Hip pain	1.5	1.9	6.5	-0.4	-2.5	0.4	-0.4	-1.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.6	0.5	1.6	-0.1	0.7	1.4
High cholesterol (Self-reported)	1.1	2.0	4.0	1.5	-0.6	0.3	2.0	1.8
Medication: Bendroflumethiazide	0.5	0.7	1.3	0.5	1.1	-0.6	1.0	0.9
Medication: Paracetamol	0.5	0.8	2.1	-0.8	-0.7	0.3	-1.4	-0.8
Medication: Lisinopril	0.3	0.4	0.9	0.9	0.4	-0.7	-0.1	0.4
Medication: Atorvastatin	0.7	0.9	2.4	1.5	-0.0	-0.6	0.5	1.1
Illnesses of father: High blood pressure	0.5	0.6	1.0	-0.7	-0.2	1.0	0.9	-0.9
Alcohol drinker status: Never	0.2	0.2	0.6	0.1	-0.8	0.7	0.1	0.0
Ever smoked	1.3	2.3	5.0	0.6	2.2	-1.9	0.0	1.7
Basal metabolic rate	0.7	4.1	9.4	-0.0	-1.6	3.1	2.8	0.9
Leg fat percentage (left)	0.1	0.3	1.1	-0.4	-1.1	0.3	-0.1	-0.3
Arm fat-free mass (left)	0.8	4.1	12.6	-1.0	-1.9	3.5	1.8	-0.2
Number of operations (self-reported)	1.8	2.7	8.0	-2.8	-1.2	0.1	-0.7	-1.9
Average weekly beer plus cider intake	0.5	0.7	1.3	0.5	-0.2	1.0	1.1	0.8
Irritability	0.8	1.3	3.1	-0.6	1.8	-1.6	-0.6	-0.2
Risk taking	2.0	2.9	5.8	-2.4	-1.0	0.2	-1.9	-2.0
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.8	-0.9	0.9	0.1	-0.5	-0.3
Fractured/broken bones in last 5 years	0.7	0.9	2.7	-0.6	-0.6	0.4	-1.6	-1.0
Age started oral contraceptive pill	1.7	2.2	4.4	-2.1	0.3	-1.2	-1.7	-1.4
Diastolic blood pressure, automated reading	0.4	1.1	2.2	-1.5	-0.3	-1.2	-0.1	-1.3
Ever depressed for a whole week	0.9	1.1	2.4	0.7	0.6	0.8	1.2	1.5
Unable to work because of sickness or disability	1.7	2.3	5.7	2.4	0.5	-0.5	2.0	1.1
Commuting to job workplace: Cycle	0.7	0.9	2.6	-0.7	1.6	0.1	-1.1	-0.1
Myopia	0.4	0.5	1.1	0.8	0.0	-0.3	0.8	1.0
Vascular/heart problems diagnosed by doctor	0.5	1.5	4.7	-0.8	-0.7	2.2	-1.1	-0.6
Cholesterol lowering medication	2.0	3.0	5.7	2.3	-0.3	0.7	2.4	1.9
Medication: Omeprazole (e.g. Zanprol)	3.9	4.8	13.2	-1.5	-2.4	3.6	-0.5	-1.6
Pain experienced in last month	0.2	0.3	1.2	-0.5	1.1	-0.2	-0.1	-0.5
Supplements: Calcium	0.3	0.3	0.7	-0.3	-0.8	0.5	-0.0	-0.8
Basal cell carcinoma (self-reported)	0.5	0.5	0.9	-0.8	-1.0	0.8	-0.3	-0.6
Heart attack/myocardial infarction (self-reported)	1.8	2.3	6.6	0.4	-2.1	2.6	0.3	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.4	-1.2	-1.2	0.9	0.5	0.4
Heart disease (siblings)	0.9	1.1	2.7	0.1	1.2	-0.6	1.6	0.9
Alcohol drinker status: Previous	1.0	1.2	4.2	0.1	0.4	-2.0	-1.0	-0.6
Pack years of smoking	1.5	2.2	4.8	-2.2	-0.9	-0.1	-1.1	-2.0
Impedance of whole body	1.1	5.6	14.1	-0.4	0.1	-3.8	-3.5	-1.3
Leg fat mass (left)	0.3	1.0	2.0	-0.5	-1.4	1.4	1.0	0.1
Arm predicted mass (left)	0.8	3.8	11.6	-0.7	-1.9	3.4	1.9	0.1