Hub : Genes

RGS9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.159 0.0561 0.0015 0.009 NA 0.004 NA 0.008 0.067 NA 0.16 NA 0.082
2 GTEx Pancreas 0.395 0.1060 0.0021 0.004 NA -0.001 NA -0.004 0.210 NA 0.38 NA 0.550
3 GTEx Vagina 0.477 0.1220 0.0027 -0.013 NA 0.005 NA -0.013 0.900 NA 0.25 NA 0.880

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.2 1.9 1.3 1.4 0.2
Bipolar Disorder or Schizophrenia 0.2 0.5 0.9 -0.3 0.8 -1.0
Depressed Affect (Nagel 2018) 0.8 1.7 3.8 -1.1 -0.1 -1.9
Depression (Nagel 2018) 0.6 1.0 2.5 0.5 0.2 -1.6
Intelligence (Savage-Jansen 2018) 0.7 2.2 3.5 1.2 1.9 1.3
Neuroticism (Nagel 2018) 0.5 1.2 2.6 -0.9 0.5 -1.6
Schizophrenia (2018) 0.6 1.3 2.0 -1.4 -0.1 -1.4
Schizophrenia vs Biploar Disorder 1.6 2.1 5.4 -2.3 0.9 0.5
Worry (Nagel 2018) 0.8 1.6 4.0 -0.9 -0.0 -2.0
Alzheimer’s Disease (in mother) 0.9 1.0 1.9 -1.4 -0.9 0.5
Alzheimer’s Disease (in father) 1.9 2.0 5.4 2.3 0.3 0.8
Alzheimer’s Disease (including proxy) 0.8 1.2 1.8 1.0 -0.8 1.3
Crohns Disease (2017) 0.4 0.8 1.3 -1.1 0.1 1.1
Irritable Bowel Disease (IBD) 0.2 0.4 0.8 -0.3 -0.9 0.6
Ulcerative Colitis (UC) 0.4 0.7 2.1 -0.1 -1.4 0.1
Major Depression (MDD) 0.8 0.9 1.5 0.1 1.2 1.1
Reaction Time 0.4 0.7 0.9 0.9 -1.0 -0.6
Verbal and Numeric Reasoning (VNR) 0.5 1.2 2.7 0.9 1.6 0.3
Breast Cancer 0.1 0.3 0.5 0.2 -0.7 -0.4
Ovarian Cancer 0.2 0.3 0.8 -0.1 -0.9 0.4
Prostate Cancer 0.7 1.0 1.4 -1.2 1.2 0.6
Age at First Birth 0.8 1.2 3.2 0.7 1.8 0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 -0.1 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.4 1.2 0.3 0.5
Coronary Artery Disease (CAD) 0.7 0.8 2.4 0.3 -0.1 1.5
Crohns Disease (2012) 1.1 1.8 4.0 -1.2 -0.3 2.0
Mean Putamen Volume 0.3 0.4 0.8 0.5 -0.1 -0.9
Fasting Glucose 0.9 1.1 2.6 -1.6 0.0 0.9
HbA1C 0.5 0.6 0.7 -0.8 -0.7 0.8
HDL Cholesterol 0.5 0.9 1.5 0.4 -0.9 -1.2
LDL Cholesterol 0.0 0.0 0.0 0.2 0.1 0.0
Lupus 0.4 0.6 1.3 0.5 -1.1 -0.5
Neuroticism (2016) 0.6 0.9 1.1 -1.0 0.8 1.0
Primary Biliary Cirrhosis 0.4 0.5 1.1 1.0 -0.5 0.5
Rheumatoid Arthritis 0.4 0.5 1.0 -0.5 -0.5 -1.0
Schizophrenia (2014) 0.7 1.6 2.6 -1.5 -0.1 -1.6
Triglycerides 0.4 0.7 1.5 -0.4 1.2 0.5
Type 2 Diabetes (T2D) (2012) 0.4 0.5 0.8 -0.7 0.9 0.1
Ulcerative Colitis 0.3 0.4 0.6 0.4 -0.8 0.7
Blood Eosinophil Count 0.1 0.7 1.8 0.5 -1.4 -0.3
Blood Platelet Count 0.1 1.6 3.2 0.9 -1.8 -1.0
Blood Red Count 0.1 1.4 2.3 -0.3 -1.3 -1.5
Blood White Count 0.1 0.6 1.0 0.3 -1.0 -0.9
Heel T-Score 2.3 17.9 52.0 -7.2 -0.8 -1.1
BMI 0.2 1.3 2.6 1.6 -1.0 0.6
Height 0.1 2.4 4.6 -2.1 -0.5 1.6
Waist Hip Ratio (WHR) 0.3 1.2 3.0 -0.7 0.3 1.7
Systolic Blood Pressure 0.5 2.4 3.9 -0.2 -2.0 -1.8
Smoking Status 0.5 1.2 3.4 -0.2 -1.9 -0.4
Allergy or Eczema 0.6 1.5 4.2 -0.6 0.1 2.0
Cardiovascular Disease 0.2 0.6 1.0 -1.0 -0.9 -0.4
Hypothyroidism (self reported) 0.8 1.9 4.9 0.6 2.2 0.7
Respiratory disease 1.2 2.6 7.5 -0.3 -2.7 -0.6
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.1 -0.5 0.5 1.1
Lung FEV1/FVC ratio 0.1 0.6 1.3 0.7 -0.2 1.1
Lung FVC 0.4 2.0 6.0 -0.0 2.5 -0.1
Neuroticism 0.3 0.8 1.3 -1.1 -0.2 -1.0
Chronotype (morning person) 0.6 1.4 3.8 -0.6 -1.9 0.1
Hair Pigment 0.3 7.2 16.2 1.6 -1.7 4.0
Tanning 0.1 1.1 2.8 0.4 1.7 -0.6
Hand grip strength (left) 0.8 2.0 3.4 -0.5 1.8 1.6
Number of treatments/medications taken 0.6 1.0 2.8 0.4 -1.7 -0.3
Average weekly spirits intake 0.9 1.1 1.6 1.3 -0.3 -1.3
Sensitivity / hurt feelings 0.2 0.3 0.6 -0.8 0.6 -0.3
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.7 -0.3 -1.9 -0.3
Hearing difficulty/problems: Yes 0.3 0.5 1.1 0.3 -0.5 -1.0
Relative age of first facial hair 1.5 3.1 8.5 -2.9 0.8 0.5
Other serious medical condition/disability diagnosed by doctor 1.0 1.2 3.3 0.6 0.4 -1.8
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 0.1 -0.6 0.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.2 -1.1 -0.5 -1.1
Systolic blood pressure, automated reading 0.4 1.3 2.8 -0.0 -1.0 -1.7
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.0 -0.3 1.0 -0.4
Angina 1.1 1.4 2.6 1.6 -1.3 0.2
Medication for hormone replacement therapy 0.7 0.7 2.0 0.2 -1.4 -0.3
Vitamin and mineral supplements 0.7 0.9 2.4 1.5 0.4 -0.4
Supplements: Zinc 1.6 1.8 3.3 -0.2 1.4 1.8
Medication: Co-codamol 0.5 0.6 1.0 -0.0 -0.9 -1.0
Medication: Metformin 0.5 0.7 1.6 0.6 -0.5 1.3
Diabetes (father) 0.0 0.0 0.1 0.2 0.3 -0.2
Diabetes (mother) 0.0 0.1 0.1 0.1 -0.3 0.3
Severe depression (siblings) 0.7 0.8 2.0 -1.4 0.6 0.3
Pack years adult smoking proportion 0.9 1.4 3.5 -0.5 0.6 -1.9
Impedance of leg (right) 0.0 0.1 0.2 -0.5 0.1 0.1
Leg fat-free mass (left) 0.0 0.1 0.3 -0.5 0.3 0.2
Trunk fat percentage 0.4 1.6 3.6 1.9 -1.1 0.3
Hand grip strength (right) 0.6 1.7 2.5 -0.3 1.6 1.6
Townsend deprivation index at recruitment 0.9 1.3 2.6 -1.6 -0.8 -0.8
Current tobacco smoking 0.5 0.8 1.0 1.0 0.7 -0.9
Average weekly fortified wine intake 0.2 0.2 0.4 0.6 -0.3 0.2
Maternal smoking around birth 0.2 0.4 0.6 -0.3 0.7 -0.6
Fed-up feelings 1.1 2.1 5.3 -0.9 -0.1 -2.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.3 0.7 -0.3 0.2 -0.8
Relative age voice broke 1.3 2.0 5.0 -2.2 -0.1 -1.0
Taking other prescription medications 1.2 1.9 4.8 -0.3 -0.8 -2.2
Age when periods started (menarche) 0.1 0.2 0.2 0.4 -0.5 0.4
Bilateral oophorectomy (both ovaries removed) 1.7 1.9 3.0 -1.5 -0.8 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.1 15.0 -3.9 -0.6 0.0
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.7 -0.9 0.0 0.5
Qualifications: CSEs or equivalent 1.5 2.0 3.3 -1.0 -1.8 1.4
Serious illness, injury or assault to yourself 0.1 0.1 0.2 -0.3 0.0 -0.4
High blood pressure 0.5 1.4 3.6 -0.0 -0.7 -1.9
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.8 -0.1 -0.6 1.3
Multivitamins +/- minerals 0.3 0.4 0.8 -0.9 0.6 0.4
Stomach or abdominal pain in last month 0.1 0.2 0.4 -0.3 -0.6 0.2
Supplements: Glucosamine 0.5 0.6 1.5 -1.2 -0.4 0.4
Diverticular disease/diverticulitis (self-reported) 0.8 0.9 2.2 -1.5 -0.1 0.7
Medication: Atenolol 2.5 3.2 4.5 1.1 -2.1 -2.0
Medication: Levothyroxine sodium 0.9 1.6 4.7 -0.3 2.2 -0.0
Sitting height 0.3 1.8 4.5 -2.1 0.7 -0.8
Chronic bronchitis/emphysema (father) 1.7 2.0 3.1 -1.8 -1.6 -0.7
High blood pressure (mother) 1.7 2.4 6.7 0.1 -2.6 0.7
Body mass index (BMI) 0.0 0.2 0.5 0.7 0.2 -0.2
Impedance of leg (left) 0.0 0.2 0.6 -0.3 0.2 0.8
Leg predicted mass (left) 0.0 0.1 0.3 -0.5 0.2 0.2
Trunk fat mass 0.2 0.9 1.9 1.4 -0.7 0.3
Waist circumference 0.1 0.2 0.5 0.2 -0.3 0.7
Number of incorrect matches in round 0.7 1.2 3.3 1.8 -0.3 -0.4
Past tobacco smoking 1.8 3.4 9.8 0.5 3.1 -0.2
Alcohol usually taken with meals 0.2 0.3 0.8 -0.1 -0.5 -0.9
Nervous feelings 0.0 0.1 0.2 0.3 0.0 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.2 0.1 -0.5 0.0
Hearing difficulty/problems with background noise 0.9 1.4 2.2 1.3 -0.5 -1.5
Hair/balding pattern: Pattern 2 3.5 4.4 9.5 -0.1 1.9 -3.1
Had menopause 0.2 0.2 0.4 0.3 0.3 -0.6
Had other major operations 0.8 0.9 1.7 -1.3 -1.0 0.1
Forced vital capacity (FVC) 0.6 2.3 5.7 -0.6 2.4 0.9
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.6 13.5 -3.7 -0.5 0.0
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.0 -0.2 0.9 1.0
Qualifications: None of the above 1.5 3.3 4.4 -1.5 -1.7 -2.1
Financial difficulties in last 2 years 0.1 0.2 0.5 -0.7 0.2 -0.2
Mouth/teeth dental problems 0.1 0.1 0.2 -0.2 -0.5 -0.2
Heart attack 0.7 0.9 1.7 1.3 -0.7 0.7
Allergy 0.4 0.9 2.1 -0.4 1.4 -0.6
Pain all over the body in last month 0.2 0.2 0.5 0.4 0.1 0.7
Diabetes (self-reported) 0.2 0.3 0.4 -0.0 0.6 0.7
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 3.6 0.1 0.5 1.9
Medication: Ramipril 1.4 1.8 5.0 -0.6 0.5 -2.2
Medication: Simvastatin 0.4 0.6 1.2 0.3 -1.1 0.7
Fluid intelligence score 0.6 1.2 2.1 1.1 1.4 0.6
Illnesses of siblings 0.1 0.1 0.2 -0.5 0.3 -0.0
Neuroticism score 0.4 0.9 1.9 -1.4 0.5 -0.7
Weight 0.0 0.1 0.2 -0.1 0.4 0.1
Impedance of arm (right) 0.3 1.5 3.6 1.0 -1.9 -0.1
Arm fat percentage (right) 0.6 2.2 4.7 2.2 -1.4 -0.1
Trunk fat-free mass 0.3 1.5 3.3 -1.8 0.9 0.5
Hip circumference 0.0 0.2 0.5 0.7 -0.2 0.0
Time employed in main current job 0.6 0.6 1.1 0.9 -1.0 -0.2
Alcohol intake versus 10 years previously 0.4 0.6 0.9 -1.0 -0.8 -0.5
Father’s age at death 0.2 0.2 0.4 0.4 0.3 -0.7
Worrier / anxious feelings 1.0 1.8 3.2 -1.1 1.1 -1.8
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.2 3.2 0.2 -1.8 -0.6
Falls in the last year 1.1 1.5 3.9 -2.0 -0.7 -0.4
Hair/balding pattern: Pattern 3 0.2 0.4 0.9 -0.3 -0.3 0.9
Number of live births 1.1 1.6 2.6 -0.2 1.5 1.6
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 4.5 -0.4 2.1 0.9
Pulse rate 0.4 0.7 1.8 -0.1 1.3 0.6
Happiness 0.2 0.3 0.8 0.9 -0.1 0.1
Noisy workplace 2.1 2.6 4.2 -2.0 -1.9 0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 -0.4 0.8 0.2
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 4.3 -1.0 2.1 0.5
Mouth/teeth dental problems: Dentures 0.1 0.2 0.3 0.3 0.6 0.2
Asthma 1.0 2.0 6.0 -0.1 -2.4 -0.3
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 0.8 0.4 0.9 0.7
Medication: Cholesterol lowering 0.1 0.2 0.6 0.1 -0.8 -0.0
Depression (self-reported) 1.2 1.4 4.1 2.0 -0.3 -0.1
Medication: Lansoprazole 1.0 1.1 2.1 -0.2 -1.5 -1.0
Prospective memory result 0.6 0.7 1.6 -1.3 0.3 -0.6
Lung cancer (father) 0.5 0.6 1.2 -1.1 -0.8 0.0
Illnesses of mother 2.8 3.5 8.9 -1.2 3.0 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 5.1 -0.5 2.2 0.9
Pulse wave Arterial Stiffness index 0.6 0.7 0.9 -0.8 0.7 1.0
Impedance of arm (left) 0.3 1.2 2.5 1.0 -1.6 0.4
Arm fat mass (right) 0.1 0.5 1.0 1.0 -0.7 -0.3
Trunk predicted mass 0.3 1.5 3.5 -1.9 0.9 0.5
Standing height 0.2 1.5 3.2 -1.8 0.6 1.0
Length of working week for main job 1.3 1.5 2.7 0.0 -1.3 1.6
Exposure to tobacco smoke at home 1.0 1.1 2.7 0.7 -0.3 -1.6
Breastfed as a baby 1.0 1.2 1.5 -1.0 1.2 1.0
Tense / ‘highly strung’ 0.3 0.4 1.1 -1.1 0.0 -0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 1.6 1.3 -1.0 -0.0
Hair/balding pattern: Pattern 4 0.3 0.8 1.5 -0.4 -0.7 -1.2
Birth weight of first child 0.7 1.2 1.9 -0.6 1.2 1.4
Peak expiratory flow (PEF) 0.7 1.7 2.7 0.1 1.6 1.6
Pulse wave reflection index 0.4 0.5 1.1 -1.0 -0.4 0.6
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.4 0.7 -0.4 1.2
Loud music exposure frequency 1.7 1.9 2.9 -0.1 -1.7 1.7
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.4 0.7 0.4 0.1
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.6 1.6 -0.2 0.2
Blood clot in the leg (DVT) 0.5 0.7 1.1 0.9 -0.5 1.0
Medication: Paracetamol 0.2 0.3 0.7 0.3 0.3 0.8
Headache pain in last month 0.3 0.5 0.7 0.7 -0.5 0.8
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.5 0.6 0.1 0.7
Glaucoma (self-reported) 0.4 0.5 1.2 -0.2 0.4 -1.1
Gout (self-reported) 0.5 0.7 1.2 1.1 -0.8 0.4
Hypothyroidism/myxoedema (self-reported) 0.8 1.6 3.7 1.0 1.9 0.4
Medication: Amlodipine 1.8 2.5 5.7 0.9 0.9 -2.4
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.3 0.4 -0.3 -0.5
Birth weight 0.8 1.8 3.8 0.2 -2.0 1.2
Chronic bronchitis/emphysema (mother) 0.0 0.1 0.2 -0.0 -0.4 0.1
High blood pressure (siblings) 0.5 0.8 1.8 0.7 -1.4 -0.2
Forced vital capacity (FVC), Best measure 0.7 2.7 6.6 -0.6 2.6 1.0
Body fat percentage 0.4 1.4 3.1 1.8 -1.1 0.3
Leg fat percentage (right) 0.2 0.6 1.7 1.3 -0.4 0.1
Arm fat-free mass (right) 0.3 1.3 2.1 -1.4 1.2 0.7
Exposure to tobacco smoke outside home 1.0 1.3 1.9 1.0 -1.0 -1.4
Comparative body size at age 10 0.4 1.2 2.5 1.6 -0.4 -0.9
Number of full brothers 0.3 0.3 0.7 -0.9 -0.3 0.5
Worry too long after embarrassment 0.7 1.1 1.6 -1.3 1.1 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.2 0.0 0.6
Wheeze or whistling in the chest in last year 2.0 3.5 8.1 -1.2 -2.9 -1.0
Number of children fathered 0.5 0.6 1.2 -0.0 1.1 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.4 1.2 0.1 -0.1 -1.1
Age at first live birth 0.3 0.6 0.9 1.0 0.8 0.1
Pulse wave peak to peak time 0.5 0.5 0.6 0.6 -0.8 -0.8
Health satisfaction 1.1 1.4 3.7 0.8 1.9 -0.1
Shortness of breath walking on level ground 0.1 0.2 0.4 -0.6 0.2 -0.3
Qualifications: College or University degree 0.2 0.8 2.1 0.5 1.4 0.1
Eye problems/disorders: None of the above 1.6 1.8 3.0 -0.9 -1.3 1.7
Mouth/teeth dental problems: Loose teeth 0.3 0.4 0.6 0.8 0.7 0.3
Emphysema/chronic bronchitis 0.4 0.5 1.1 -0.6 -1.1 0.2
Medication for pain relief, constipation, heartburn 0.4 0.7 1.6 0.1 0.7 -1.2
Neck or shoulder pain in last month 0.4 0.6 1.0 0.7 -0.5 -1.0
Medication: Blood pressure 0.4 0.8 1.0 -0.7 0.9 -1.0
Angina (self-reported) 1.1 1.4 2.5 1.6 -1.3 0.0
Migraine (self-reported) 0.2 0.2 0.5 0.7 -0.0 0.4
Medication: Ibuprofen 0.3 0.4 0.6 0.7 0.2 0.8
Medication: Allopurinol 0.7 0.9 1.8 0.6 -1.4 0.8
Medication: Omeprazole 0.3 0.4 1.0 -0.3 -1.0 0.0
Medication: Seretide 50 evohaler 0.4 0.5 0.7 -0.8 -0.8 0.4
Mean time to correctly identify matches 0.8 1.5 4.4 0.5 -2.1 -0.1
Heart disease (mother) 0.2 0.3 0.7 0.1 -0.9 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 5.3 -0.6 0.4 2.3
Whole body fat mass 0.1 0.5 0.9 0.9 -0.8 0.1
Leg fat mass (right) 0.1 0.2 0.5 0.7 -0.2 0.3
Arm predicted mass (right) 0.3 1.5 3.2 -1.8 1.0 0.6
Pulse rate, automated reading 0.1 0.5 1.0 -0.4 1.0 0.5
Alcohol intake frequency. 0.4 1.0 1.2 -1.1 -0.9 -1.0
Comparative height size at age 10 0.1 0.8 1.6 1.3 -0.6 -0.7
Number of full sisters 0.6 0.8 2.2 -1.5 -0.3 -0.1
Suffer from ‘nerves’ 0.1 0.2 0.3 -0.5 0.5 0.2
Overall health rating 0.2 0.4 1.0 0.1 0.3 -1.0
Chest pain or discomfort 1.0 1.4 1.7 0.8 -1.3 1.3
Had major operations 2.6 3.0 4.3 1.4 1.6 -2.1
Age at last live birth 1.2 1.8 5.2 0.3 2.3 0.3
Family relationship satisfaction 0.6 0.7 1.7 0.3 -0.6 -1.3
Leg pain on walking 0.9 1.1 3.2 1.8 -0.3 -0.1
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.3 0.0 -0.4
Commuting to job workplace: Car/motor vehicle 1.3 1.5 4.1 2.0 -0.3 0.6
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.7 -0.3 -1.3 1.1
Medication: Aspirin 0.3 0.4 0.9 0.4 0.9 0.3
Supplements: Vitamin C 0.3 0.4 0.9 -0.2 -0.9 0.5
Knee pain experienced in last month 1.5 2.3 2.8 -1.7 -1.6 -1.2
Hypertension (Self-reported) 0.5 1.5 3.7 -0.1 -0.8 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.5 0.8 0.9 0.0 -0.9
Illnesses of father: Heart disease 0.3 0.4 0.8 0.4 0.9 -0.4
Illnesses of siblings: Diabetes 0.4 0.4 1.2 0.2 1.1 -0.1
Smoking status: Previous 2.1 3.2 9.4 -0.1 -3.1 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 1.5 3.1 6.4 -1.0 2.5 1.3
Whole body fat-free mass 0.2 0.9 2.0 -1.4 0.7 0.5
Leg fat-free mass (right) 0.0 0.2 0.3 -0.5 0.3 0.5
Arm fat percentage (left) 0.4 1.7 3.8 2.0 -1.1 -0.0
Average weekly red wine intake 0.9 1.3 1.6 1.2 -1.3 -0.8
Handedness (chirality/laterality): Left-handed 1.2 1.4 2.1 1.4 0.7 1.3
Mood swings 0.3 0.5 0.9 -1.0 -0.7 0.2
Loneliness, isolation 0.4 0.5 1.0 -0.7 0.2 -1.0
Long-standing illness, disability or infirmity 0.9 1.4 2.9 0.6 -1.0 -1.7
Ever had bowel cancer screening 0.9 1.1 3.1 0.4 -1.8 0.2
Diabetes diagnosed by doctor 0.2 0.4 0.6 -0.2 0.7 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.7 1.0 -1.0 0.3 1.0
Friendships satisfaction 0.3 0.4 0.7 -0.9 -0.3 -0.6
Qualifications: nursing, teaching 0.3 0.5 1.0 0.5 0.5 1.0
Commuting to job workplace: Walk 0.3 0.3 0.9 -1.0 0.0 0.1
Eye problems/disorders: Cataract 0.8 1.0 1.7 0.5 1.3 -0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.1 -0.2 -0.6
Medication for cholesterol 0.5 0.8 2.2 0.3 1.5 -0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.0 1.9 -0.1 1.1 -1.4
Back pain experienced in last month 0.4 0.6 1.3 0.1 -0.6 -1.2
Mineral and other dietary supplements 1.0 1.4 2.5 1.1 1.6 -0.7
Breast cancer (self-reported) 0.6 0.7 1.3 0.2 -1.1 -0.9
Asthma (self-reported) 1.0 2.1 6.0 0.2 -2.4 -0.4
Osteoporosis (self-reported) 0.4 0.5 1.0 1.0 0.5 -0.2
Osteoarthritis (self-reported) 1.4 1.8 5.3 -0.1 -0.4 -2.3
Medication: Aspirin 0.4 0.5 0.9 0.9 0.7 0.5
Medication: Gliclazide 0.9 1.0 1.6 -1.2 -1.2 0.1
Illnesses of father: None of the above (group 1) 0.5 0.6 1.6 -0.0 -0.3 1.3
Smoking status: Current 0.3 0.6 0.8 0.9 0.5 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 4.1 0.4 2.0 1.2
Whole body water mass 0.2 1.0 2.2 -1.5 0.7 0.5
Leg predicted mass (right) 0.0 0.2 0.3 -0.6 0.2 0.5
Arm fat mass (left) 0.1 0.3 0.5 0.7 -0.5 -0.0
Number of self-reported non-cancer illnesses 1.2 2.0 4.1 0.9 -2.0 -1.1
Average weekly champagne plus white wine intake 0.1 0.1 0.2 -0.2 0.2 0.5
Miserableness 0.0 0.0 0.0 -0.2 -0.1 0.0
Guilty feelings 0.5 0.7 1.7 1.3 0.2 0.7
Wears glasses or contact lenses 2.2 2.5 3.9 -0.9 2.0 1.7
Ever taken oral contraceptive pill 2.0 2.3 4.0 0.8 1.5 2.0
Hearing aid user 2.0 2.2 5.1 2.3 1.3 -0.0
Mother’s age at death 0.4 0.5 1.2 1.1 -0.5 -0.0
Financial situation satisfaction 2.2 2.8 8.0 0.5 -2.8 0.1
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.2 -0.3 0.4
Commuting to job workplace: Public transport 0.6 0.7 1.7 -1.3 -0.5 -0.3
Eye problems/disorders: Glaucoma 0.7 0.8 1.3 0.0 1.1 -1.1
Medication: Blood pressure 0.5 0.9 2.2 -0.2 -0.7 -1.5
Pain type(s) experienced in last month: Hip pain 1.2 1.5 4.0 -0.1 0.6 -2.0
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.3 -1.5 -1.3 -0.4
High cholesterol (Self-reported) 0.2 0.4 0.9 -0.5 -0.9 0.3
Medication: Bendroflumethiazide 0.6 0.8 2.5 0.2 -1.6 -0.0
Medication: Paracetamol 0.2 0.4 0.6 0.7 0.1 0.8
Medication: Lisinopril 1.6 2.1 5.3 -0.7 2.3 0.6
Medication: Atorvastatin 0.0 0.0 0.1 -0.0 0.3 0.1
Illnesses of father: High blood pressure 0.1 0.2 0.3 -0.3 0.6 0.4
Alcohol drinker status: Never 0.3 0.4 0.6 0.4 -0.8 0.7
Ever smoked 1.2 2.1 6.1 0.1 -2.5 -0.3
Basal metabolic rate 0.1 0.5 1.0 -1.0 0.5 0.4
Leg fat percentage (left) 0.3 1.0 2.6 1.6 -0.4 0.4
Arm fat-free mass (left) 0.2 1.3 2.1 -1.4 1.2 0.5
Number of operations (self-reported) 0.4 0.5 1.0 0.7 -0.3 -1.0
Average weekly beer plus cider intake 0.3 0.4 0.7 -0.9 -0.0 -0.6
Irritability 0.2 0.3 0.5 -0.7 -0.2 0.5
Risk taking 1.3 1.9 4.9 0.3 -2.2 0.8
Ever had prostate specific antigen (PSA) test 3.2 3.7 6.8 2.6 2.0 -0.6
Fractured/broken bones in last 5 years 0.2 0.2 0.6 0.8 0.3 0.1
Age started oral contraceptive pill 0.0 0.0 0.1 0.0 -0.0 0.4
Diastolic blood pressure, automated reading 0.2 0.7 1.1 0.5 -1.1 -0.8
Ever depressed for a whole week 1.0 1.2 1.9 1.4 0.1 1.4
Unable to work because of sickness or disability 0.6 0.8 1.4 -1.2 -0.2 -0.9
Commuting to job workplace: Cycle 1.6 2.0 3.3 -1.8 -1.1 -1.2
Myopia 0.2 0.3 0.4 -0.6 -0.6 0.0
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.4 -0.2 1.1 1.5
Cholesterol lowering medication 0.2 0.3 0.7 0.4 -0.8 0.2
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.8 -0.5 -1.3 0.4
Pain experienced in last month 0.2 0.3 0.6 0.6 -0.3 0.8
Supplements: Calcium 0.7 0.7 1.3 -1.1 -0.9 0.0
Basal cell carcinoma (self-reported) 1.2 1.5 3.9 0.6 0.4 2.0
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.3 1.1 -0.8 0.7
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 1.4 1.1 -0.7 1.2
Heart disease (siblings) 0.5 0.7 1.3 1.1 0.2 0.8
Alcohol drinker status: Previous 0.3 0.3 0.5 -0.7 -0.3 -0.7
Pack years of smoking 1.0 1.4 3.6 -0.8 0.3 -1.9
Impedance of whole body 0.1 0.4 0.8 0.6 -0.9 0.4
Leg fat mass (left) 0.1 0.4 0.8 0.9 -0.3 0.4
Arm predicted mass (left) 0.3 1.3 2.2 -1.5 1.2 0.4