Hub : Genes

RGS9

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.159	0.0561	0.0015	0.009	NA	0.004	NA	0.008	0.067	NA	0.16	NA	0.082
2	GTEx	Pancreas	0.395	0.1060	0.0021	0.004	NA	-0.001	NA	-0.004	0.210	NA	0.38	NA	0.550
3	GTEx	Vagina	0.477	0.1220	0.0027	-0.013	NA	0.005	NA	-0.013	0.900	NA	0.25	NA	0.880

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.8	1.2	1.9	1.3	1.4	0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	-0.3	0.8	-1.0
Depressed Affect (Nagel 2018)	0.8	1.7	3.8	-1.1	-0.1	-1.9
Depression (Nagel 2018)	0.6	1.0	2.5	0.5	0.2	-1.6
Intelligence (Savage-Jansen 2018)	0.7	2.2	3.5	1.2	1.9	1.3
Neuroticism (Nagel 2018)	0.5	1.2	2.6	-0.9	0.5	-1.6
Schizophrenia (2018)	0.6	1.3	2.0	-1.4	-0.1	-1.4
Schizophrenia vs Biploar Disorder	1.6	2.1	5.4	-2.3	0.9	0.5
Worry (Nagel 2018)	0.8	1.6	4.0	-0.9	-0.0	-2.0
Alzheimer’s Disease (in mother)	0.9	1.0	1.9	-1.4	-0.9	0.5
Alzheimer’s Disease (in father)	1.9	2.0	5.4	2.3	0.3	0.8
Alzheimer’s Disease (including proxy)	0.8	1.2	1.8	1.0	-0.8	1.3
Crohns Disease (2017)	0.4	0.8	1.3	-1.1	0.1	1.1
Irritable Bowel Disease (IBD)	0.2	0.4	0.8	-0.3	-0.9	0.6
Ulcerative Colitis (UC)	0.4	0.7	2.1	-0.1	-1.4	0.1
Major Depression (MDD)	0.8	0.9	1.5	0.1	1.2	1.1
Reaction Time	0.4	0.7	0.9	0.9	-1.0	-0.6
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	0.9	1.6	0.3
Breast Cancer	0.1	0.3	0.5	0.2	-0.7	-0.4
Ovarian Cancer	0.2	0.3	0.8	-0.1	-0.9	0.4
Prostate Cancer	0.7	1.0	1.4	-1.2	1.2	0.6
Age at First Birth	0.8	1.2	3.2	0.7	1.8	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	-0.1	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	1.2	0.3	0.5
Coronary Artery Disease (CAD)	0.7	0.8	2.4	0.3	-0.1	1.5
Crohns Disease (2012)	1.1	1.8	4.0	-1.2	-0.3	2.0
Mean Putamen Volume	0.3	0.4	0.8	0.5	-0.1	-0.9
Fasting Glucose	0.9	1.1	2.6	-1.6	0.0	0.9
HbA1C	0.5	0.6	0.7	-0.8	-0.7	0.8
HDL Cholesterol	0.5	0.9	1.5	0.4	-0.9	-1.2
LDL Cholesterol	0.0	0.0	0.0	0.2	0.1	0.0
Lupus	0.4	0.6	1.3	0.5	-1.1	-0.5
Neuroticism (2016)	0.6	0.9	1.1	-1.0	0.8	1.0
Primary Biliary Cirrhosis	0.4	0.5	1.1	1.0	-0.5	0.5
Rheumatoid Arthritis	0.4	0.5	1.0	-0.5	-0.5	-1.0
Schizophrenia (2014)	0.7	1.6	2.6	-1.5	-0.1	-1.6
Triglycerides	0.4	0.7	1.5	-0.4	1.2	0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.8	-0.7	0.9	0.1
Ulcerative Colitis	0.3	0.4	0.6	0.4	-0.8	0.7
Blood Eosinophil Count	0.1	0.7	1.8	0.5	-1.4	-0.3
Blood Platelet Count	0.1	1.6	3.2	0.9	-1.8	-1.0
Blood Red Count	0.1	1.4	2.3	-0.3	-1.3	-1.5
Blood White Count	0.1	0.6	1.0	0.3	-1.0	-0.9
Heel T-Score	2.3	17.9	52.0	-7.2	-0.8	-1.1
BMI	0.2	1.3	2.6	1.6	-1.0	0.6
Height	0.1	2.4	4.6	-2.1	-0.5	1.6
Waist Hip Ratio (WHR)	0.3	1.2	3.0	-0.7	0.3	1.7
Systolic Blood Pressure	0.5	2.4	3.9	-0.2	-2.0	-1.8
Smoking Status	0.5	1.2	3.4	-0.2	-1.9	-0.4
Allergy or Eczema	0.6	1.5	4.2	-0.6	0.1	2.0
Cardiovascular Disease	0.2	0.6	1.0	-1.0	-0.9	-0.4
Hypothyroidism (self reported)	0.8	1.9	4.9	0.6	2.2	0.7
Respiratory disease	1.2	2.6	7.5	-0.3	-2.7	-0.6
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.1	-0.5	0.5	1.1
Lung FEV1/FVC ratio	0.1	0.6	1.3	0.7	-0.2	1.1
Lung FVC	0.4	2.0	6.0	-0.0	2.5	-0.1
Neuroticism	0.3	0.8	1.3	-1.1	-0.2	-1.0
Chronotype (morning person)	0.6	1.4	3.8	-0.6	-1.9	0.1
Hair Pigment	0.3	7.2	16.2	1.6	-1.7	4.0
Tanning	0.1	1.1	2.8	0.4	1.7	-0.6
Hand grip strength (left)	0.8	2.0	3.4	-0.5	1.8	1.6
Number of treatments/medications taken	0.6	1.0	2.8	0.4	-1.7	-0.3
Average weekly spirits intake	0.9	1.1	1.6	1.3	-0.3	-1.3
Sensitivity / hurt feelings	0.2	0.3	0.6	-0.8	0.6	-0.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.7	-0.3	-1.9	-0.3
Hearing difficulty/problems: Yes	0.3	0.5	1.1	0.3	-0.5	-1.0
Relative age of first facial hair	1.5	3.1	8.5	-2.9	0.8	0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.2	3.3	0.6	0.4	-1.8
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.1	-0.6	0.2
Ever had hysterectomy (womb removed)	0.7	0.8	1.2	-1.1	-0.5	-1.1
Systolic blood pressure, automated reading	0.4	1.3	2.8	-0.0	-1.0	-1.7
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.0	-0.3	1.0	-0.4
Angina	1.1	1.4	2.6	1.6	-1.3	0.2
Medication for hormone replacement therapy	0.7	0.7	2.0	0.2	-1.4	-0.3
Vitamin and mineral supplements	0.7	0.9	2.4	1.5	0.4	-0.4
Supplements: Zinc	1.6	1.8	3.3	-0.2	1.4	1.8
Medication: Co-codamol	0.5	0.6	1.0	-0.0	-0.9	-1.0
Medication: Metformin	0.5	0.7	1.6	0.6	-0.5	1.3
Diabetes (father)	0.0	0.0	0.1	0.2	0.3	-0.2
Diabetes (mother)	0.0	0.1	0.1	0.1	-0.3	0.3
Severe depression (siblings)	0.7	0.8	2.0	-1.4	0.6	0.3
Pack years adult smoking proportion	0.9	1.4	3.5	-0.5	0.6	-1.9
Impedance of leg (right)	0.0	0.1	0.2	-0.5	0.1	0.1
Leg fat-free mass (left)	0.0	0.1	0.3	-0.5	0.3	0.2
Trunk fat percentage	0.4	1.6	3.6	1.9	-1.1	0.3
Hand grip strength (right)	0.6	1.7	2.5	-0.3	1.6	1.6
Townsend deprivation index at recruitment	0.9	1.3	2.6	-1.6	-0.8	-0.8
Current tobacco smoking	0.5	0.8	1.0	1.0	0.7	-0.9
Average weekly fortified wine intake	0.2	0.2	0.4	0.6	-0.3	0.2
Maternal smoking around birth	0.2	0.4	0.6	-0.3	0.7	-0.6
Fed-up feelings	1.1	2.1	5.3	-0.9	-0.1	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	-0.3	0.2	-0.8
Relative age voice broke	1.3	2.0	5.0	-2.2	-0.1	-1.0
Taking other prescription medications	1.2	1.9	4.8	-0.3	-0.8	-2.2
Age when periods started (menarche)	0.1	0.2	0.2	0.4	-0.5	0.4
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.0	-1.5	-0.8	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	2.3	5.1	15.0	-3.9	-0.6	0.0
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.7	-0.9	0.0	0.5
Qualifications: CSEs or equivalent	1.5	2.0	3.3	-1.0	-1.8	1.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	-0.3	0.0	-0.4
High blood pressure	0.5	1.4	3.6	-0.0	-0.7	-1.9
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.8	-0.1	-0.6	1.3
Multivitamins +/- minerals	0.3	0.4	0.8	-0.9	0.6	0.4
Stomach or abdominal pain in last month	0.1	0.2	0.4	-0.3	-0.6	0.2
Supplements: Glucosamine	0.5	0.6	1.5	-1.2	-0.4	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.2	-1.5	-0.1	0.7
Medication: Atenolol	2.5	3.2	4.5	1.1	-2.1	-2.0
Medication: Levothyroxine sodium	0.9	1.6	4.7	-0.3	2.2	-0.0
Sitting height	0.3	1.8	4.5	-2.1	0.7	-0.8
Chronic bronchitis/emphysema (father)	1.7	2.0	3.1	-1.8	-1.6	-0.7
High blood pressure (mother)	1.7	2.4	6.7	0.1	-2.6	0.7
Body mass index (BMI)	0.0	0.2	0.5	0.7	0.2	-0.2
Impedance of leg (left)	0.0	0.2	0.6	-0.3	0.2	0.8
Leg predicted mass (left)	0.0	0.1	0.3	-0.5	0.2	0.2
Trunk fat mass	0.2	0.9	1.9	1.4	-0.7	0.3
Waist circumference	0.1	0.2	0.5	0.2	-0.3	0.7
Number of incorrect matches in round	0.7	1.2	3.3	1.8	-0.3	-0.4
Past tobacco smoking	1.8	3.4	9.8	0.5	3.1	-0.2
Alcohol usually taken with meals	0.2	0.3	0.8	-0.1	-0.5	-0.9
Nervous feelings	0.0	0.1	0.2	0.3	0.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	0.1	-0.5	0.0
Hearing difficulty/problems with background noise	0.9	1.4	2.2	1.3	-0.5	-1.5
Hair/balding pattern: Pattern 2	3.5	4.4	9.5	-0.1	1.9	-3.1
Had menopause	0.2	0.2	0.4	0.3	0.3	-0.6
Had other major operations	0.8	0.9	1.7	-1.3	-1.0	0.1
Forced vital capacity (FVC)	0.6	2.3	5.7	-0.6	2.4	0.9
Heel bone mineral density (BMD) T-score, automated (right)	2.0	4.6	13.5	-3.7	-0.5	0.0
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.2	0.9	1.0
Qualifications: None of the above	1.5	3.3	4.4	-1.5	-1.7	-2.1
Financial difficulties in last 2 years	0.1	0.2	0.5	-0.7	0.2	-0.2
Mouth/teeth dental problems	0.1	0.1	0.2	-0.2	-0.5	-0.2
Heart attack	0.7	0.9	1.7	1.3	-0.7	0.7
Allergy	0.4	0.9	2.1	-0.4	1.4	-0.6
Pain all over the body in last month	0.2	0.2	0.5	0.4	0.1	0.7
Diabetes (self-reported)	0.2	0.3	0.4	-0.0	0.6	0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.6	0.1	0.5	1.9
Medication: Ramipril	1.4	1.8	5.0	-0.6	0.5	-2.2
Medication: Simvastatin	0.4	0.6	1.2	0.3	-1.1	0.7
Fluid intelligence score	0.6	1.2	2.1	1.1	1.4	0.6
Illnesses of siblings	0.1	0.1	0.2	-0.5	0.3	-0.0
Neuroticism score	0.4	0.9	1.9	-1.4	0.5	-0.7
Weight	0.0	0.1	0.2	-0.1	0.4	0.1
Impedance of arm (right)	0.3	1.5	3.6	1.0	-1.9	-0.1
Arm fat percentage (right)	0.6	2.2	4.7	2.2	-1.4	-0.1
Trunk fat-free mass	0.3	1.5	3.3	-1.8	0.9	0.5
Hip circumference	0.0	0.2	0.5	0.7	-0.2	0.0
Time employed in main current job	0.6	0.6	1.1	0.9	-1.0	-0.2
Alcohol intake versus 10 years previously	0.4	0.6	0.9	-1.0	-0.8	-0.5
Father’s age at death	0.2	0.2	0.4	0.4	0.3	-0.7
Worrier / anxious feelings	1.0	1.8	3.2	-1.1	1.1	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.2	3.2	0.2	-1.8	-0.6
Falls in the last year	1.1	1.5	3.9	-2.0	-0.7	-0.4
Hair/balding pattern: Pattern 3	0.2	0.4	0.9	-0.3	-0.3	0.9
Number of live births	1.1	1.6	2.6	-0.2	1.5	1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	4.5	-0.4	2.1	0.9
Pulse rate	0.4	0.7	1.8	-0.1	1.3	0.6
Happiness	0.2	0.3	0.8	0.9	-0.1	0.1
Noisy workplace	2.1	2.6	4.2	-2.0	-1.9	0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	-0.4	0.8	0.2
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	4.3	-1.0	2.1	0.5
Mouth/teeth dental problems: Dentures	0.1	0.2	0.3	0.3	0.6	0.2
Asthma	1.0	2.0	6.0	-0.1	-2.4	-0.3
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	0.4	0.9	0.7
Medication: Cholesterol lowering	0.1	0.2	0.6	0.1	-0.8	-0.0
Depression (self-reported)	1.2	1.4	4.1	2.0	-0.3	-0.1
Medication: Lansoprazole	1.0	1.1	2.1	-0.2	-1.5	-1.0
Prospective memory result	0.6	0.7	1.6	-1.3	0.3	-0.6
Lung cancer (father)	0.5	0.6	1.2	-1.1	-0.8	0.0
Illnesses of mother	2.8	3.5	8.9	-1.2	3.0	-0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	5.1	-0.5	2.2	0.9
Pulse wave Arterial Stiffness index	0.6	0.7	0.9	-0.8	0.7	1.0
Impedance of arm (left)	0.3	1.2	2.5	1.0	-1.6	0.4
Arm fat mass (right)	0.1	0.5	1.0	1.0	-0.7	-0.3
Trunk predicted mass	0.3	1.5	3.5	-1.9	0.9	0.5
Standing height	0.2	1.5	3.2	-1.8	0.6	1.0
Length of working week for main job	1.3	1.5	2.7	0.0	-1.3	1.6
Exposure to tobacco smoke at home	1.0	1.1	2.7	0.7	-0.3	-1.6
Breastfed as a baby	1.0	1.2	1.5	-1.0	1.2	1.0
Tense / ‘highly strung’	0.3	0.4	1.1	-1.1	0.0	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.6	1.3	-1.0	-0.0
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	-0.4	-0.7	-1.2
Birth weight of first child	0.7	1.2	1.9	-0.6	1.2	1.4
Peak expiratory flow (PEF)	0.7	1.7	2.7	0.1	1.6	1.6
Pulse wave reflection index	0.4	0.5	1.1	-1.0	-0.4	0.6
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.4	0.7	-0.4	1.2
Loud music exposure frequency	1.7	1.9	2.9	-0.1	-1.7	1.7
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.7	0.4	0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.6	1.6	-0.2	0.2
Blood clot in the leg (DVT)	0.5	0.7	1.1	0.9	-0.5	1.0
Medication: Paracetamol	0.2	0.3	0.7	0.3	0.3	0.8
Headache pain in last month	0.3	0.5	0.7	0.7	-0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.6	0.1	0.7
Glaucoma (self-reported)	0.4	0.5	1.2	-0.2	0.4	-1.1
Gout (self-reported)	0.5	0.7	1.2	1.1	-0.8	0.4
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	3.7	1.0	1.9	0.4
Medication: Amlodipine	1.8	2.5	5.7	0.9	0.9	-2.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.3	0.4	-0.3	-0.5
Birth weight	0.8	1.8	3.8	0.2	-2.0	1.2
Chronic bronchitis/emphysema (mother)	0.0	0.1	0.2	-0.0	-0.4	0.1
High blood pressure (siblings)	0.5	0.8	1.8	0.7	-1.4	-0.2
Forced vital capacity (FVC), Best measure	0.7	2.7	6.6	-0.6	2.6	1.0
Body fat percentage	0.4	1.4	3.1	1.8	-1.1	0.3
Leg fat percentage (right)	0.2	0.6	1.7	1.3	-0.4	0.1
Arm fat-free mass (right)	0.3	1.3	2.1	-1.4	1.2	0.7
Exposure to tobacco smoke outside home	1.0	1.3	1.9	1.0	-1.0	-1.4
Comparative body size at age 10	0.4	1.2	2.5	1.6	-0.4	-0.9
Number of full brothers	0.3	0.3	0.7	-0.9	-0.3	0.5
Worry too long after embarrassment	0.7	1.1	1.6	-1.3	1.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.2	0.0	0.6
Wheeze or whistling in the chest in last year	2.0	3.5	8.1	-1.2	-2.9	-1.0
Number of children fathered	0.5	0.6	1.2	-0.0	1.1	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.2	0.1	-0.1	-1.1
Age at first live birth	0.3	0.6	0.9	1.0	0.8	0.1
Pulse wave peak to peak time	0.5	0.5	0.6	0.6	-0.8	-0.8
Health satisfaction	1.1	1.4	3.7	0.8	1.9	-0.1
Shortness of breath walking on level ground	0.1	0.2	0.4	-0.6	0.2	-0.3
Qualifications: College or University degree	0.2	0.8	2.1	0.5	1.4	0.1
Eye problems/disorders: None of the above	1.6	1.8	3.0	-0.9	-1.3	1.7
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.6	0.8	0.7	0.3
Emphysema/chronic bronchitis	0.4	0.5	1.1	-0.6	-1.1	0.2
Medication for pain relief, constipation, heartburn	0.4	0.7	1.6	0.1	0.7	-1.2
Neck or shoulder pain in last month	0.4	0.6	1.0	0.7	-0.5	-1.0
Medication: Blood pressure	0.4	0.8	1.0	-0.7	0.9	-1.0
Angina (self-reported)	1.1	1.4	2.5	1.6	-1.3	0.0
Migraine (self-reported)	0.2	0.2	0.5	0.7	-0.0	0.4
Medication: Ibuprofen	0.3	0.4	0.6	0.7	0.2	0.8
Medication: Allopurinol	0.7	0.9	1.8	0.6	-1.4	0.8
Medication: Omeprazole	0.3	0.4	1.0	-0.3	-1.0	0.0
Medication: Seretide 50 evohaler	0.4	0.5	0.7	-0.8	-0.8	0.4
Mean time to correctly identify matches	0.8	1.5	4.4	0.5	-2.1	-0.1
Heart disease (mother)	0.2	0.3	0.7	0.1	-0.9	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	5.3	-0.6	0.4	2.3
Whole body fat mass	0.1	0.5	0.9	0.9	-0.8	0.1
Leg fat mass (right)	0.1	0.2	0.5	0.7	-0.2	0.3
Arm predicted mass (right)	0.3	1.5	3.2	-1.8	1.0	0.6
Pulse rate, automated reading	0.1	0.5	1.0	-0.4	1.0	0.5
Alcohol intake frequency.	0.4	1.0	1.2	-1.1	-0.9	-1.0
Comparative height size at age 10	0.1	0.8	1.6	1.3	-0.6	-0.7
Number of full sisters	0.6	0.8	2.2	-1.5	-0.3	-0.1
Suffer from ‘nerves’	0.1	0.2	0.3	-0.5	0.5	0.2
Overall health rating	0.2	0.4	1.0	0.1	0.3	-1.0
Chest pain or discomfort	1.0	1.4	1.7	0.8	-1.3	1.3
Had major operations	2.6	3.0	4.3	1.4	1.6	-2.1
Age at last live birth	1.2	1.8	5.2	0.3	2.3	0.3
Family relationship satisfaction	0.6	0.7	1.7	0.3	-0.6	-1.3
Leg pain on walking	0.9	1.1	3.2	1.8	-0.3	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	-0.3	0.0	-0.4
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.1	2.0	-0.3	0.6
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.7	-0.3	-1.3	1.1
Medication: Aspirin	0.3	0.4	0.9	0.4	0.9	0.3
Supplements: Vitamin C	0.3	0.4	0.9	-0.2	-0.9	0.5
Knee pain experienced in last month	1.5	2.3	2.8	-1.7	-1.6	-1.2
Hypertension (Self-reported)	0.5	1.5	3.7	-0.1	-0.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.8	0.9	0.0	-0.9
Illnesses of father: Heart disease	0.3	0.4	0.8	0.4	0.9	-0.4
Illnesses of siblings: Diabetes	0.4	0.4	1.2	0.2	1.1	-0.1
Smoking status: Previous	2.1	3.2	9.4	-0.1	-3.1	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	6.4	-1.0	2.5	1.3
Whole body fat-free mass	0.2	0.9	2.0	-1.4	0.7	0.5
Leg fat-free mass (right)	0.0	0.2	0.3	-0.5	0.3	0.5
Arm fat percentage (left)	0.4	1.7	3.8	2.0	-1.1	-0.0
Average weekly red wine intake	0.9	1.3	1.6	1.2	-1.3	-0.8
Handedness (chirality/laterality): Left-handed	1.2	1.4	2.1	1.4	0.7	1.3
Mood swings	0.3	0.5	0.9	-1.0	-0.7	0.2
Loneliness, isolation	0.4	0.5	1.0	-0.7	0.2	-1.0
Long-standing illness, disability or infirmity	0.9	1.4	2.9	0.6	-1.0	-1.7
Ever had bowel cancer screening	0.9	1.1	3.1	0.4	-1.8	0.2
Diabetes diagnosed by doctor	0.2	0.4	0.6	-0.2	0.7	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	1.0	-1.0	0.3	1.0
Friendships satisfaction	0.3	0.4	0.7	-0.9	-0.3	-0.6
Qualifications: nursing, teaching	0.3	0.5	1.0	0.5	0.5	1.0
Commuting to job workplace: Walk	0.3	0.3	0.9	-1.0	0.0	0.1
Eye problems/disorders: Cataract	0.8	1.0	1.7	0.5	1.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.1	-0.2	-0.6
Medication for cholesterol	0.5	0.8	2.2	0.3	1.5	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	1.9	-0.1	1.1	-1.4
Back pain experienced in last month	0.4	0.6	1.3	0.1	-0.6	-1.2
Mineral and other dietary supplements	1.0	1.4	2.5	1.1	1.6	-0.7
Breast cancer (self-reported)	0.6	0.7	1.3	0.2	-1.1	-0.9
Asthma (self-reported)	1.0	2.1	6.0	0.2	-2.4	-0.4
Osteoporosis (self-reported)	0.4	0.5	1.0	1.0	0.5	-0.2
Osteoarthritis (self-reported)	1.4	1.8	5.3	-0.1	-0.4	-2.3
Medication: Aspirin	0.4	0.5	0.9	0.9	0.7	0.5
Medication: Gliclazide	0.9	1.0	1.6	-1.2	-1.2	0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.6	-0.0	-0.3	1.3
Smoking status: Current	0.3	0.6	0.8	0.9	0.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	4.1	0.4	2.0	1.2
Whole body water mass	0.2	1.0	2.2	-1.5	0.7	0.5
Leg predicted mass (right)	0.0	0.2	0.3	-0.6	0.2	0.5
Arm fat mass (left)	0.1	0.3	0.5	0.7	-0.5	-0.0
Number of self-reported non-cancer illnesses	1.2	2.0	4.1	0.9	-2.0	-1.1
Average weekly champagne plus white wine intake	0.1	0.1	0.2	-0.2	0.2	0.5
Miserableness	0.0	0.0	0.0	-0.2	-0.1	0.0
Guilty feelings	0.5	0.7	1.7	1.3	0.2	0.7
Wears glasses or contact lenses	2.2	2.5	3.9	-0.9	2.0	1.7
Ever taken oral contraceptive pill	2.0	2.3	4.0	0.8	1.5	2.0
Hearing aid user	2.0	2.2	5.1	2.3	1.3	-0.0
Mother’s age at death	0.4	0.5	1.2	1.1	-0.5	-0.0
Financial situation satisfaction	2.2	2.8	8.0	0.5	-2.8	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.2	-0.3	0.4
Commuting to job workplace: Public transport	0.6	0.7	1.7	-1.3	-0.5	-0.3
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	0.0	1.1	-1.1
Medication: Blood pressure	0.5	0.9	2.2	-0.2	-0.7	-1.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.0	-0.1	0.6	-2.0
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.3	-1.5	-1.3	-0.4
High cholesterol (Self-reported)	0.2	0.4	0.9	-0.5	-0.9	0.3
Medication: Bendroflumethiazide	0.6	0.8	2.5	0.2	-1.6	-0.0
Medication: Paracetamol	0.2	0.4	0.6	0.7	0.1	0.8
Medication: Lisinopril	1.6	2.1	5.3	-0.7	2.3	0.6
Medication: Atorvastatin	0.0	0.0	0.1	-0.0	0.3	0.1
Illnesses of father: High blood pressure	0.1	0.2	0.3	-0.3	0.6	0.4
Alcohol drinker status: Never	0.3	0.4	0.6	0.4	-0.8	0.7
Ever smoked	1.2	2.1	6.1	0.1	-2.5	-0.3
Basal metabolic rate	0.1	0.5	1.0	-1.0	0.5	0.4
Leg fat percentage (left)	0.3	1.0	2.6	1.6	-0.4	0.4
Arm fat-free mass (left)	0.2	1.3	2.1	-1.4	1.2	0.5
Number of operations (self-reported)	0.4	0.5	1.0	0.7	-0.3	-1.0
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.9	-0.0	-0.6
Irritability	0.2	0.3	0.5	-0.7	-0.2	0.5
Risk taking	1.3	1.9	4.9	0.3	-2.2	0.8
Ever had prostate specific antigen (PSA) test	3.2	3.7	6.8	2.6	2.0	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.6	0.8	0.3	0.1
Age started oral contraceptive pill	0.0	0.0	0.1	0.0	-0.0	0.4
Diastolic blood pressure, automated reading	0.2	0.7	1.1	0.5	-1.1	-0.8
Ever depressed for a whole week	1.0	1.2	1.9	1.4	0.1	1.4
Unable to work because of sickness or disability	0.6	0.8	1.4	-1.2	-0.2	-0.9
Commuting to job workplace: Cycle	1.6	2.0	3.3	-1.8	-1.1	-1.2
Myopia	0.2	0.3	0.4	-0.6	-0.6	0.0
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.4	-0.2	1.1	1.5
Cholesterol lowering medication	0.2	0.3	0.7	0.4	-0.8	0.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.8	-0.5	-1.3	0.4
Pain experienced in last month	0.2	0.3	0.6	0.6	-0.3	0.8
Supplements: Calcium	0.7	0.7	1.3	-1.1	-0.9	0.0
Basal cell carcinoma (self-reported)	1.2	1.5	3.9	0.6	0.4	2.0
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	1.1	-0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.4	1.1	-0.7	1.2
Heart disease (siblings)	0.5	0.7	1.3	1.1	0.2	0.8
Alcohol drinker status: Previous	0.3	0.3	0.5	-0.7	-0.3	-0.7
Pack years of smoking	1.0	1.4	3.6	-0.8	0.3	-1.9
Impedance of whole body	0.1	0.4	0.8	0.6	-0.9	0.4
Leg fat mass (left)	0.1	0.4	0.8	0.9	-0.3	0.4
Arm predicted mass (left)	0.3	1.3	2.2	-1.5	1.2	0.4