Hub : Genes

RHBDD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Esophagus Muscularis 0.1490 0.0560 8.6e-04 0.007 NA 0.028 NA 0.016 1.1e-01 NA 8.0e-03 NA 3.4e-02
2 GTEx Testis 0.3160 0.0920 4.8e-04 0.272 NA 0.289 NA 0.299 1.8e-12 NA 2.9e-13 NA 9.1e-14
3 ROSMAP Brain Pre-frontal Cortex 0.0671 0.0211 7.4e-06 0.074 0.046 0.081 0.071 0.076 8.8e-10 1.2e-06 1.4e-10 1.8e-09 4.6e-10

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 1.7 -0.3 1.3 -0.1
Bipolar Disorder or Schizophrenia 1.0 2.4 4.9 -0.7 2.2 -1.3
Depressed Affect (Nagel 2018) 2.8 5.8 9.7 2.7 -0.8 3.1
Depression (Nagel 2018) 0.6 0.8 1.3 1.2 0.4 1.0
Intelligence (Savage-Jansen 2018) 0.2 0.8 1.2 -1.0 0.1 -1.1
Neuroticism (Nagel 2018) 1.0 2.4 3.6 1.9 0.3 1.9
Schizophrenia (2018) 1.0 2.1 3.1 -0.8 1.8 -1.6
Schizophrenia vs Biploar Disorder 0.2 0.3 0.9 0.9 0.2 0.0
Worry (Nagel 2018) 1.1 2.3 3.1 1.5 1.1 1.8
Alzheimer’s Disease (in mother) 0.1 0.2 0.2 -0.4 -0.4 -0.4
Alzheimer’s Disease (in father) 2.3 2.4 2.8 -1.6 1.4 -1.7
Alzheimer’s Disease (including proxy) 1.0 1.4 2.5 -1.6 0.5 -1.2
Crohns Disease (2017) 0.8 1.7 2.6 -1.6 1.0 -1.3
Irritable Bowel Disease (IBD) 0.3 0.7 1.5 -1.2 0.2 -0.7
Ulcerative Colitis (UC) 0.1 0.2 0.4 -0.2 -0.6 0.4
Major Depression (MDD) 0.7 0.8 2.3 -0.3 -0.1 -1.5
Reaction Time 0.5 1.0 2.2 0.8 -1.5 0.5
Verbal and Numeric Reasoning (VNR) 0.1 0.3 0.5 -0.7 -0.4 -0.3
Breast Cancer 0.5 1.2 2.4 0.1 1.1 1.6
Ovarian Cancer 1.7 2.2 3.9 -0.7 2.0 -1.5
Prostate Cancer 0.8 1.1 3.0 1.7 -0.3 0.2
Age at First Birth 0.3 0.4 0.7 -0.8 0.0 -0.8
Bipolar Disorder (2011) 1.3 1.3 2.6 -1.0 1.6 -0.4
Body Mass Index (BMI) (2010) 5.0 6.8 10.4 -1.8 2.6 -3.2
Coronary Artery Disease (CAD) 1.2 1.4 2.6 1.6 -0.5 1.2
Crohns Disease (2012) 0.2 0.3 0.6 -0.3 0.8 0.3
Mean Putamen Volume 0.1 0.1 0.3 0.3 -0.5 -0.1
Fasting Glucose 1.0 1.2 2.4 -1.6 0.8 -0.7
HbA1C 0.9 0.9 1.8 1.4 0.9 0.4
HDL Cholesterol 3.5 5.8 14.1 -3.8 1.1 -1.4
LDL Cholesterol 1.7 2.7 4.8 2.2 -0.9 1.6
Lupus 0.1 0.2 0.3 -0.4 0.6 -0.4
Neuroticism (2016) 0.7 1.1 2.1 1.4 0.6 0.9
Primary Biliary Cirrhosis 0.0 0.1 0.2 -0.4 -0.2 -0.1
Rheumatoid Arthritis 0.7 0.9 1.5 1.2 0.7 0.8
Schizophrenia (2014) 0.6 1.3 2.6 -0.1 1.6 -1.2
Triglycerides 3.2 5.3 8.7 3.0 -1.3 2.3
Type 2 Diabetes (T2D) (2012) 0.9 1.1 3.1 1.8 0.1 0.3
Ulcerative Colitis 0.3 0.5 0.7 0.5 -0.7 0.8
Blood Eosinophil Count 0.8 6.2 9.9 3.1 -1.6 2.5
Blood Platelet Count 0.0 0.1 0.2 0.2 0.4 -0.4
Blood Red Count 0.1 0.9 1.0 1.0 -1.0 0.8
Blood White Count 0.2 1.7 4.7 0.4 2.2 -0.4
Heel T-Score 0.4 3.0 6.8 2.6 -0.3 1.5
BMI 1.3 7.3 11.4 -3.4 0.2 -3.3
Height 1.2 23.7 41.3 4.4 -6.4 3.3
Waist Hip Ratio (WHR) 0.5 2.3 3.3 1.8 0.8 1.8
Systolic Blood Pressure 1.9 9.7 19.7 4.4 -1.0 2.9
Smoking Status 0.2 0.4 0.6 -0.1 0.8 -0.7
Allergy or Eczema 0.5 1.3 3.3 -0.7 1.8 -0.3
Cardiovascular Disease 0.8 2.7 7.1 2.7 -0.5 0.9
Hypothyroidism (self reported) 0.9 2.1 3.8 1.9 1.4 0.8
Respiratory disease 1.1 2.4 6.2 -2.5 -0.0 -1.0
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.3 0.3 -0.6 -0.5
Lung FEV1/FVC ratio 1.8 9.3 20.2 4.5 0.7 2.7
Lung FVC 3.8 19.1 31.2 -4.7 1.9 -5.6
Neuroticism 1.7 4.1 6.8 2.3 -0.7 2.6
Chronotype (morning person) 0.2 0.6 1.0 0.8 -0.4 1.0
Hair Pigment 0.1 3.6 7.0 1.7 -2.6 1.1
Tanning 0.0 0.1 0.2 0.0 0.1 -0.5
Hand grip strength (left) 0.3 0.9 2.5 0.4 -1.6 0.2
Number of treatments/medications taken 0.8 1.5 2.0 1.4 -1.2 1.0
Average weekly spirits intake 3.3 4.1 8.0 -2.8 1.2 -1.7
Sensitivity / hurt feelings 0.1 0.2 0.4 0.6 -0.5 0.3
Frequency of depressed mood in last 2 weeks 1.2 1.7 2.0 1.4 1.2 1.3
Hearing difficulty/problems: Yes 3.4 5.2 8.0 2.7 -0.4 2.8
Relative age of first facial hair 7.3 15.1 22.3 3.7 -4.7 3.1
Other serious medical condition/disability diagnosed by doctor 1.2 1.5 2.8 -1.2 0.7 -1.7
Ever used hormone-replacement therapy (HRT) 0.1 0.2 0.3 0.5 -0.4 0.1
Ever had hysterectomy (womb removed) 1.9 2.2 4.2 1.0 -2.0 1.2
Systolic blood pressure, automated reading 1.0 3.0 6.4 2.5 -0.3 1.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 -0.3 -0.9 0.0
Angina 2.3 3.0 6.9 2.6 -1.0 1.0
Medication for hormone replacement therapy 0.7 0.7 1.6 1.3 0.4 0.7
Vitamin and mineral supplements 0.5 0.6 1.4 -1.2 0.4 -0.5
Supplements: Zinc 0.7 0.8 1.3 -1.1 -0.8 -0.6
Medication: Co-codamol 0.1 0.1 0.2 0.4 -0.3 -0.2
Medication: Metformin 0.3 0.4 0.7 -0.6 0.6 -0.8
Diabetes (father) 0.6 0.8 1.8 0.1 0.7 -1.4
Diabetes (mother) 0.5 0.6 1.4 0.5 -0.4 1.2
Severe depression (siblings) 1.9 2.1 3.2 -1.8 0.1 -1.7
Pack years adult smoking proportion 0.1 0.2 0.5 -0.4 0.7 -0.1
Impedance of leg (right) 0.3 1.3 2.2 1.3 0.3 1.5
Leg fat-free mass (left) 0.5 2.5 7.4 -0.3 -2.7 -0.1
Trunk fat percentage 1.9 7.6 16.8 -4.1 0.5 -2.4
Hand grip strength (right) 0.6 1.5 2.6 -0.9 -1.0 -1.6
Townsend deprivation index at recruitment 1.4 2.0 2.9 -1.6 -1.7 -0.9
Current tobacco smoking 0.3 0.6 1.1 -1.0 0.8 0.2
Average weekly fortified wine intake 0.4 0.5 1.0 0.6 0.4 1.0
Maternal smoking around birth 3.2 4.6 5.9 -2.4 1.9 -2.0
Fed-up feelings 2.6 4.7 9.1 2.2 -0.3 3.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.6 1.3 -0.1 1.6
Relative age voice broke 4.1 6.3 9.6 2.2 -3.1 2.1
Taking other prescription medications 0.5 0.8 2.1 1.4 -0.6 0.1
Age when periods started (menarche) 1.6 3.9 5.9 -2.2 1.0 -2.4
Bilateral oophorectomy (both ovaries removed) 3.3 3.8 5.1 1.9 -2.3 1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.0 0.7 0.4 -1.0
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.3 0.6 0.5 0.2
Qualifications: CSEs or equivalent 0.5 0.7 2.0 0.1 0.4 1.4
Serious illness, injury or assault to yourself 2.1 2.5 4.1 -1.5 1.0 -2.0
High blood pressure 0.4 1.1 2.5 1.6 0.2 0.9
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.5 -0.2 0.7 0.2
Multivitamins +/- minerals 0.1 0.1 0.3 0.5 -0.1 -0.2
Stomach or abdominal pain in last month 0.0 0.1 0.1 -0.3 -0.1 -0.2
Supplements: Glucosamine 2.4 3.1 3.7 1.8 -1.5 1.9
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.3 1.1 -0.8 0.8
Medication: Atenolol 3.3 4.1 6.7 2.6 -2.1 1.2
Medication: Levothyroxine sodium 0.8 1.4 4.0 2.0 -0.2 0.2
Sitting height 0.9 6.0 10.4 2.7 -3.2 0.8
Chronic bronchitis/emphysema (father) 2.1 2.5 4.4 -1.8 -0.0 -2.1
High blood pressure (mother) 3.3 4.6 6.2 2.5 -1.5 2.3
Body mass index (BMI) 1.3 5.7 10.2 -3.2 0.8 -2.5
Impedance of leg (left) 0.2 0.8 1.5 1.0 0.3 1.2
Leg predicted mass (left) 0.5 2.7 7.9 -0.3 -2.8 -0.1
Trunk fat mass 1.1 4.5 9.5 -3.1 -0.2 -2.0
Waist circumference 0.5 1.7 3.3 -1.8 0.6 -1.1
Number of incorrect matches in round 0.6 1.0 2.5 0.3 0.6 1.6
Past tobacco smoking 1.9 3.5 6.1 0.6 -2.0 2.5
Alcohol usually taken with meals 0.6 1.0 1.7 0.5 -1.3 1.0
Nervous feelings 1.6 2.9 4.1 2.0 1.3 1.8
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 3.5 0.4 1.9 0.8
Hearing difficulty/problems with background noise 0.9 1.5 2.5 1.4 0.0 1.6
Hair/balding pattern: Pattern 2 0.8 1.0 1.8 -1.0 0.6 -1.3
Had menopause 0.9 1.2 1.7 -0.7 1.2 -1.3
Had other major operations 0.7 0.9 1.9 -0.8 1.4 -0.1
Forced vital capacity (FVC) 0.5 1.8 3.6 -0.8 -1.0 -1.9
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 2.3 0.3 0.7 -1.5
Ever unenthusiastic/disinterested for a whole week 0.8 0.9 1.5 -0.8 0.8 -1.2
Qualifications: None of the above 0.1 0.1 0.2 -0.4 0.4 0.2
Financial difficulties in last 2 years 0.5 0.6 1.1 -0.6 0.6 -1.1
Mouth/teeth dental problems 2.2 3.4 6.9 -0.3 -2.6 1.8
Heart attack 1.7 2.2 5.1 2.3 -1.1 0.4
Allergy 0.5 1.1 2.9 1.7 -0.6 0.2
Pain all over the body in last month 0.1 0.1 0.2 0.0 0.4 -0.2
Diabetes (self-reported) 0.3 0.5 1.0 -0.6 -0.3 -1.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.1 -0.4 0.2 0.3
Medication: Ramipril 0.1 0.2 0.3 0.6 -0.4 0.2
Medication: Simvastatin 1.2 1.8 4.3 2.1 -1.1 0.1
Fluid intelligence score 0.2 0.5 1.0 -0.7 -0.3 -1.0
Illnesses of siblings 2.5 3.4 5.3 1.1 -2.0 2.3
Neuroticism score 0.9 1.8 3.0 1.5 0.1 1.7
Weight 0.4 1.7 3.0 -1.3 -1.7 -0.8
Impedance of arm (right) 0.2 0.9 1.2 -1.1 0.8 0.9
Arm fat percentage (right) 2.1 8.4 17.8 -4.2 1.3 -2.4
Trunk fat-free mass 1.6 9.2 16.6 2.9 -4.1 1.6
Hip circumference 0.4 1.5 2.5 -1.6 -1.1 -0.9
Time employed in main current job 2.1 2.5 7.2 -0.2 -0.3 2.7
Alcohol intake versus 10 years previously 0.5 0.8 1.5 0.8 1.2 -0.4
Father’s age at death 3.3 4.5 5.5 -2.0 2.0 -2.3
Worrier / anxious feelings 0.1 0.3 0.5 0.5 0.2 0.7
Frequency of tiredness / lethargy in last 2 weeks 2.2 3.6 6.2 2.5 0.4 2.2
Falls in the last year 0.7 0.9 2.5 0.1 -1.6 0.4
Hair/balding pattern: Pattern 3 0.1 0.1 0.2 -0.0 0.4 0.5
Number of live births 0.7 1.1 2.0 1.4 0.5 0.9
Forced expiratory volume in 1-second (FEV1) 0.2 0.8 2.2 0.3 -0.2 -1.5
Pulse rate 0.5 0.8 2.3 -1.5 -0.0 0.3
Happiness 0.4 0.4 1.1 -0.4 1.0 -0.4
Noisy workplace 1.9 2.3 6.3 2.5 0.2 0.8
Qualifications: A levels/AS levels or equivalent 0.4 0.8 1.3 -0.5 0.9 -1.1
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.6 0.2 -0.8 -0.3
Mouth/teeth dental problems: Dentures 2.1 3.5 7.3 0.0 2.7 -1.8
Asthma 1.2 2.4 6.2 -2.5 0.5 -0.8
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 0.4 0.1 0.5
Medication: Cholesterol lowering 2.3 3.5 9.2 3.0 -0.4 1.1
Depression (self-reported) 0.7 0.8 0.9 0.9 -0.9 0.8
Medication: Lansoprazole 0.9 1.0 1.8 -0.2 1.1 -1.4
Prospective memory result 3.4 4.1 6.3 1.8 -1.7 2.5
Lung cancer (father) 2.3 2.7 8.0 -0.0 2.8 -0.2
Illnesses of mother 1.2 1.5 2.9 -0.7 1.0 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.8 0.9 -0.4 -0.3
Pulse wave Arterial Stiffness index 3.2 3.7 7.0 1.9 -0.7 2.7
Impedance of arm (left) 0.2 0.9 1.4 -1.2 0.8 0.6
Arm fat mass (right) 1.1 4.4 9.4 -3.1 0.1 -2.0
Trunk predicted mass 1.6 9.3 16.7 2.9 -4.1 1.7
Standing height 2.0 19.8 30.6 4.1 -5.5 3.4
Length of working week for main job 0.6 0.6 1.2 -0.8 -0.4 -1.1
Exposure to tobacco smoke at home 0.4 0.5 1.2 -1.1 -0.5 -0.1
Breastfed as a baby 1.3 1.6 2.8 -1.7 -1.2 -0.6
Tense / ‘highly strung’ 0.8 1.4 2.6 0.5 1.1 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 0.6 -0.4 0.5 -0.8
Hair/balding pattern: Pattern 4 0.5 1.1 1.9 -1.4 -0.8 -0.9
Birth weight of first child 0.6 1.1 1.4 -1.2 -0.8 -1.1
Peak expiratory flow (PEF) 1.1 2.6 3.0 1.7 1.7 -1.4
Pulse wave reflection index 0.4 0.5 0.9 0.8 -0.2 0.9
Ever highly irritable/argumentative for 2 days 0.3 0.4 1.0 0.3 1.0 0.4
Loud music exposure frequency 1.1 1.2 1.7 -0.1 1.3 -1.3
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 4.1 -0.7 1.1 -2.0
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.4 0.3 0.0 -0.7
Blood clot in the leg (DVT) 0.5 0.7 1.2 0.7 -0.5 1.1
Medication: Paracetamol 0.5 0.8 1.3 -0.3 -1.1 1.0
Headache pain in last month 0.8 1.3 2.6 -0.8 -0.9 1.6
Medication for cholesterol, blood pressure or diabetes 2.1 3.4 9.6 -3.1 0.4 -0.7
Glaucoma (self-reported) 0.8 1.0 2.2 -0.8 0.2 -1.5
Gout (self-reported) 0.6 0.8 1.2 0.6 0.9 -1.1
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.3 1.8 0.7 0.6
Medication: Amlodipine 0.7 0.9 1.8 1.4 -0.9 0.4
Medication: Ventolin 100micrograms inhaler 1.9 2.4 4.1 -0.4 -1.7 2.0
Birth weight 0.5 1.1 2.6 -0.8 -1.6 -0.3
Chronic bronchitis/emphysema (mother) 0.7 0.9 1.5 0.7 1.2 0.8
High blood pressure (siblings) 1.1 1.6 3.2 -1.0 0.8 -1.8
Forced vital capacity (FVC), Best measure 0.3 1.2 2.5 -0.9 -0.7 -1.6
Body fat percentage 2.2 8.6 17.6 -4.2 1.0 -2.7
Leg fat percentage (right) 1.7 6.1 9.7 -3.1 1.9 -2.3
Arm fat-free mass (right) 1.0 5.4 13.7 1.5 -3.7 0.5
Exposure to tobacco smoke outside home 1.0 1.3 2.7 -1.7 0.7 -0.8
Comparative body size at age 10 2.9 8.1 11.6 -3.0 1.9 -3.4
Number of full brothers 3.4 4.3 6.2 -1.6 2.0 -2.5
Worry too long after embarrassment 0.4 0.7 1.1 -0.2 1.0 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.8 -0.2 0.4 -0.9
Wheeze or whistling in the chest in last year 0.3 0.6 1.5 -1.2 0.6 0.0
Number of children fathered 1.7 1.9 3.6 1.9 -1.3 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.8 2.1 0.2 -1.4 0.3
Age at first live birth 0.7 1.3 2.2 1.1 -1.5 0.8
Pulse wave peak to peak time 2.2 2.6 5.2 -1.6 0.3 -2.3
Health satisfaction 0.1 0.1 0.2 0.4 0.3 0.2
Shortness of breath walking on level ground 1.1 1.3 1.8 0.8 -1.4 1.2
Qualifications: College or University degree 0.1 0.4 1.0 1.0 -0.2 0.5
Eye problems/disorders: None of the above 1.7 2.0 3.9 -1.4 0.4 -2.0
Mouth/teeth dental problems: Loose teeth 2.1 2.5 3.1 -1.3 1.6 -1.8
Emphysema/chronic bronchitis 0.7 0.8 1.4 -1.2 -0.3 -0.9
Medication for pain relief, constipation, heartburn 1.1 1.9 2.9 -1.7 0.6 -1.6
Neck or shoulder pain in last month 0.9 1.3 3.7 1.9 -0.5 0.2
Medication: Blood pressure 0.5 0.9 2.6 1.6 -0.2 -0.3
Angina (self-reported) 2.2 2.9 6.2 2.5 -1.1 1.1
Migraine (self-reported) 0.3 0.3 1.0 -1.0 -0.2 -0.0
Medication: Ibuprofen 0.3 0.4 0.6 0.8 0.0 0.7
Medication: Allopurinol 0.2 0.3 0.8 0.2 0.2 -0.9
Medication: Omeprazole 1.2 1.4 1.6 1.3 -1.1 1.2
Medication: Seretide 50 evohaler 0.3 0.3 0.6 -0.8 0.6 0.1
Mean time to correctly identify matches 0.5 1.0 2.2 0.6 -1.5 0.6
Heart disease (mother) 0.7 0.8 1.0 -1.0 0.8 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 1.2 -0.0 1.1 0.1
Whole body fat mass 1.2 5.0 10.0 -3.2 -0.1 -2.2
Leg fat mass (right) 1.2 4.6 8.6 -2.9 0.6 -2.2
Arm predicted mass (right) 1.0 5.1 13.0 1.5 -3.6 0.3
Pulse rate, automated reading 0.3 1.0 2.5 -1.6 0.6 -0.3
Alcohol intake frequency. 0.2 0.4 0.8 0.5 -0.1 0.9
Comparative height size at age 10 2.6 14.4 20.1 3.4 -4.5 3.4
Number of full sisters 1.1 1.3 2.8 -0.6 1.7 -0.9
Suffer from ‘nerves’ 1.0 1.6 3.0 1.7 0.6 1.2
Overall health rating 0.6 1.4 2.2 1.5 1.0 0.9
Chest pain or discomfort 0.4 0.6 1.8 0.1 0.2 -1.3
Had major operations 1.3 1.5 2.9 1.7 -0.1 1.2
Age at last live birth 1.2 1.7 2.4 1.6 -1.3 1.0
Family relationship satisfaction 0.2 0.3 0.7 -0.8 0.2 -0.1
Leg pain on walking 0.2 0.3 0.6 0.4 -0.8 0.2
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.1 0.1 -0.0 -0.3 0.2
Commuting to job workplace: Car/motor vehicle 1.3 1.5 3.6 -0.9 1.9 0.1
Illness, injury, bereavement, stress in last 2 years 2.2 2.7 3.0 1.5 -1.7 1.7
Medication: Aspirin 0.6 0.8 2.2 1.5 0.5 -0.2
Supplements: Vitamin C 4.5 5.3 7.1 2.3 -1.9 2.7
Knee pain experienced in last month 0.0 0.0 0.1 -0.3 0.0 0.1
Hypertension (Self-reported) 0.5 1.5 3.2 1.8 0.1 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.4 0.5 1.4 1.2 0.0 0.4
Illnesses of father: Heart disease 0.3 0.4 0.5 0.6 0.5 0.7
Illnesses of siblings: Diabetes 0.7 0.8 1.4 1.0 1.2 -0.3
Smoking status: Previous 1.4 2.1 4.3 -0.0 1.4 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 4.9 10.2 15.5 3.3 -2.1 3.9
Whole body fat-free mass 0.9 5.4 13.2 1.5 -3.6 0.8
Leg fat-free mass (right) 0.5 2.9 8.6 -0.3 -2.9 -0.0
Arm fat percentage (left) 2.3 9.3 19.2 -4.4 1.3 -2.7
Average weekly red wine intake 3.1 4.6 7.5 -2.4 0.7 -2.7
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.8 -0.5 -1.4 -0.9
Mood swings 1.8 3.2 4.7 1.9 -1.2 2.2
Loneliness, isolation 0.5 0.6 1.1 1.1 0.9 0.1
Long-standing illness, disability or infirmity 0.3 0.4 0.7 -0.9 -0.1 -0.7
Ever had bowel cancer screening 0.2 0.3 0.6 -0.3 -0.4 -0.8
Diabetes diagnosed by doctor 0.3 0.5 1.4 0.5 -1.2 -0.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.7 -0.7 0.1 -0.8
Friendships satisfaction 0.4 0.5 1.2 0.0 1.1 -0.6
Qualifications: nursing, teaching 0.4 0.6 0.8 0.9 -0.8 0.6
Commuting to job workplace: Walk 0.5 0.5 0.9 0.6 -0.9 -0.5
Eye problems/disorders: Cataract 3.1 3.6 8.4 1.5 -0.3 2.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.4 0.0 0.6 -0.1
Medication for cholesterol 2.8 4.3 5.9 -2.4 1.8 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 1.4 1.0 -0.5 1.2
Back pain experienced in last month 4.1 6.0 6.9 -2.3 2.4 -2.6
Mineral and other dietary supplements 4.6 6.2 7.9 -2.8 2.1 -2.5
Breast cancer (self-reported) 1.4 1.6 4.2 -0.4 -0.7 -2.0
Asthma (self-reported) 1.2 2.4 6.2 -2.5 0.5 -0.9
Osteoporosis (self-reported) 1.2 1.5 3.6 -0.9 1.9 -0.5
Osteoarthritis (self-reported) 0.2 0.3 0.6 0.6 -0.8 0.1
Medication: Aspirin 0.5 0.7 1.9 1.4 0.3 -0.0
Medication: Gliclazide 2.9 3.3 4.3 1.8 -1.6 2.1
Illnesses of father: None of the above (group 1) 0.3 0.4 0.9 0.2 -0.4 0.9
Smoking status: Current 0.2 0.4 0.8 -0.9 0.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.1 0.2 -0.4 0.0 -0.4
Whole body water mass 1.0 5.8 14.2 1.6 -3.8 0.9
Leg predicted mass (right) 0.6 3.0 8.9 -0.3 -3.0 -0.0
Arm fat mass (left) 1.0 4.0 8.4 -2.9 -0.2 -1.9
Number of self-reported non-cancer illnesses 2.1 3.6 5.8 2.4 -0.9 2.1
Average weekly champagne plus white wine intake 0.2 0.3 0.3 -0.6 -0.5 0.5
Miserableness 1.7 3.0 5.7 1.8 -0.4 2.4
Guilty feelings 0.6 1.0 1.9 -0.2 1.0 -1.4
Wears glasses or contact lenses 0.8 1.0 2.8 -0.1 1.7 -0.3
Ever taken oral contraceptive pill 0.6 0.6 1.6 -0.5 -0.0 -1.3
Hearing aid user 1.0 1.2 2.6 1.6 -0.3 0.9
Mother’s age at death 1.2 1.5 4.3 -0.3 2.1 -0.3
Financial situation satisfaction 0.1 0.2 0.3 -0.6 0.4 0.1
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.4 1.0 -0.0 1.2
Commuting to job workplace: Public transport 0.3 0.3 0.9 -0.0 -0.0 -1.0
Eye problems/disorders: Glaucoma 0.3 0.3 1.0 0.0 -0.3 -1.0
Medication: Blood pressure 1.7 3.2 4.1 1.7 -1.6 2.0
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.1 0.7 -1.1 0.3
Supplements: Fish oil (including cod liver oil) 5.3 6.9 11.1 3.3 -2.0 2.4
High cholesterol (Self-reported) 2.6 4.7 10.6 3.2 -1.6 1.0
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.6 0.2 -0.2
Medication: Paracetamol 0.5 0.7 1.5 -1.2 -0.8 0.0
Medication: Lisinopril 1.7 2.2 3.8 1.9 -0.7 1.5
Medication: Atorvastatin 2.8 3.5 5.5 2.3 -1.3 1.8
Illnesses of father: High blood pressure 1.1 1.3 2.9 1.7 -0.6 0.8
Alcohol drinker status: Never 0.1 0.1 0.2 -0.4 -0.3 -0.3
Ever smoked 1.9 3.4 4.3 -1.4 1.9 -2.1
Basal metabolic rate 0.7 4.0 11.0 0.8 -3.3 0.5
Leg fat percentage (left) 2.0 7.2 11.5 -3.4 1.8 -2.6
Arm fat-free mass (left) 1.1 5.4 12.4 1.7 -3.5 0.9
Number of operations (self-reported) 2.9 4.2 7.0 2.6 -0.1 2.4
Average weekly beer plus cider intake 0.4 0.6 1.1 0.2 -1.1 0.7
Irritability 0.4 0.7 1.1 1.0 0.3 1.1
Risk taking 0.7 1.0 1.6 1.1 -0.5 1.3
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.7 -0.3 0.3 -0.8
Fractured/broken bones in last 5 years 0.6 0.8 1.9 0.5 -1.4 0.3
Age started oral contraceptive pill 0.6 0.7 1.2 1.1 -0.5 0.7
Diastolic blood pressure, automated reading 0.5 1.4 2.8 1.7 -0.3 1.1
Ever depressed for a whole week 0.4 0.5 1.1 -0.2 -0.5 -1.1
Unable to work because of sickness or disability 3.0 3.9 5.3 -1.5 2.3 -2.0
Commuting to job workplace: Cycle 0.6 0.7 1.7 1.3 -0.3 0.6
Myopia 8.0 11.6 14.4 -3.8 3.4 -3.0
Vascular/heart problems diagnosed by doctor 0.8 2.1 4.7 -2.2 0.3 -1.2
Cholesterol lowering medication 2.4 3.5 6.7 1.8 -2.6 0.8
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.5 1.2 -0.8 0.7
Pain experienced in last month 0.1 0.2 0.3 0.5 -0.5 0.5
Supplements: Calcium 0.6 0.6 1.5 -0.6 1.2 -0.3
Basal cell carcinoma (self-reported) 0.4 0.4 0.8 -0.6 0.4 -0.9
Heart attack/myocardial infarction (self-reported) 1.7 2.2 4.9 2.2 -1.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.3 0.8 -0.7 1.2
Heart disease (siblings) 0.8 0.9 1.4 -0.4 1.2 -1.1
Alcohol drinker status: Previous 0.4 0.4 0.8 0.4 -0.6 0.9
Pack years of smoking 0.2 0.3 0.6 -0.4 0.8 -0.4
Impedance of whole body 0.1 0.5 1.3 -0.2 0.6 1.1
Leg fat mass (left) 1.4 5.3 9.9 -3.1 0.6 -2.4
Arm predicted mass (left) 1.1 5.6 13.2 1.7 -3.6 0.8