Hub : Genes

RHOQ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0694 0.0273 0.0020 0.009 0.018 0.027 0.022 0.015 2.4e-02 0.0017 0.00016 0.0007 0.00460
2 YFS Blood 0.0296 0.0126 0.0081 0.006 0.004 0.005 0.006 0.006 4.0e-03 0.0110 0.00950 0.0036 0.00340
3 TCGA Thyroid Carcinoma 0.0680 0.0370 0.0078 0.044 0.018 0.023 NA 0.035 3.6e-05 0.0068 0.00240 NA 0.00023

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 1.4 0.4 -1.2 0.6
Bipolar Disorder or Schizophrenia 0.6 1.4 2.5 -0.2 -1.6 1.3
Depressed Affect (Nagel 2018) 0.4 0.8 1.2 1.1 1.0 0.4
Depression (Nagel 2018) 0.3 0.5 0.7 0.8 -0.8 0.4
Intelligence (Savage-Jansen 2018) 0.3 0.8 1.6 -1.2 0.0 -0.9
Neuroticism (Nagel 2018) 0.2 0.5 0.9 0.7 0.1 1.0
Schizophrenia (2018) 0.5 0.9 1.4 -0.5 -1.1 1.2
Schizophrenia vs Biploar Disorder 0.5 0.7 1.9 -1.4 0.5 -0.2
Worry (Nagel 2018) 0.4 0.7 2.2 -0.2 0.1 1.5
Alzheimer’s Disease (in mother) 0.1 0.1 0.2 0.2 0.3 0.4
Alzheimer’s Disease (in father) 0.0 0.0 0.1 -0.1 0.3 -0.1
Alzheimer’s Disease (including proxy) 0.1 0.1 0.3 0.0 0.6 -0.0
Crohns Disease (2017) 0.5 1.0 1.9 1.4 0.3 1.0
Irritable Bowel Disease (IBD) 0.0 0.0 0.0 0.0 -0.1 0.0
Ulcerative Colitis (UC) 0.3 0.5 0.9 -0.8 -0.2 -1.0
Major Depression (MDD) 0.7 0.8 1.7 0.8 0.0 -1.3
Reaction Time 0.1 0.2 0.5 0.1 -0.3 -0.7
Verbal and Numeric Reasoning (VNR) 0.2 0.4 1.2 -0.4 1.1 -0.1
Breast Cancer 0.3 0.7 1.6 -1.2 -0.6 -0.3
Ovarian Cancer 0.1 0.1 0.3 0.1 0.5 -0.0
Prostate Cancer 1.5 2.2 3.4 -1.8 0.0 -1.8
Age at First Birth 1.0 1.4 4.1 -0.3 -2.0 -0.4
Bipolar Disorder (2011) 1.0 1.0 2.7 1.6 0.5 -0.1
Body Mass Index (BMI) (2010) 0.1 0.2 0.4 0.4 0.0 -0.6
Coronary Artery Disease (CAD) 1.6 1.9 2.6 1.2 1.6 1.3
Crohns Disease (2012) 0.1 0.2 0.3 0.6 -0.2 0.5
Mean Putamen Volume 0.1 0.1 0.1 -0.3 0.4 -0.3
Fasting Glucose 0.3 0.4 0.7 0.9 -0.5 -0.4
HbA1C 0.4 0.5 0.8 0.7 -0.1 0.9
HDL Cholesterol 0.4 0.6 0.9 -0.7 -0.7 0.9
LDL Cholesterol 0.8 1.2 2.8 -1.7 0.0 -0.9
Lupus 0.7 1.1 2.9 -0.3 -1.7 -0.5
Neuroticism (2016) 0.6 0.8 2.4 0.3 1.6 0.2
Primary Biliary Cirrhosis 0.0 0.0 0.1 0.1 -0.1 0.3
Rheumatoid Arthritis 0.5 0.7 1.0 -0.4 -1.0 -1.0
Schizophrenia (2014) 0.3 0.7 1.2 -0.1 -1.0 1.1
Triglycerides 0.4 0.6 1.4 0.6 0.3 1.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.6 -0.8 -0.3 0.1
Ulcerative Colitis 0.3 0.4 0.9 -0.9 -0.0 -0.7
Blood Eosinophil Count 0.5 4.1 8.2 1.9 2.9 0.5
Blood Platelet Count 0.4 4.4 5.5 -1.9 -2.0 -2.4
Blood Red Count 0.3 2.8 5.2 2.3 0.6 1.7
Blood White Count 0.4 2.9 6.3 -2.5 0.4 -1.5
Heel T-Score 0.4 2.9 6.8 -1.2 -0.6 -2.6
BMI 1.2 7.2 9.5 -2.3 3.1 -2.6
Height 1.0 19.5 45.0 6.7 1.9 3.2
Waist Hip Ratio (WHR) 0.0 0.1 0.1 0.3 -0.3 -0.0
Systolic Blood Pressure 0.2 1.0 1.9 0.8 -0.6 1.4
Smoking Status 1.5 3.6 6.9 2.6 0.8 1.8
Allergy or Eczema 1.7 4.5 11.6 1.4 -3.4 -0.1
Cardiovascular Disease 0.2 0.8 1.4 -0.9 1.2 -0.3
Hypothyroidism (self reported) 0.8 1.8 3.5 0.4 1.9 1.2
Respiratory disease 0.7 1.5 2.6 -0.1 1.4 -1.6
Type 2 Diabetes (T2D) (2018) 0.8 1.5 2.5 -1.6 -0.7 -1.3
Lung FEV1/FVC ratio 0.6 3.2 9.1 -3.0 0.2 -0.7
Lung FVC 0.8 3.9 10.8 -0.4 -3.3 -0.9
Neuroticism 0.1 0.2 0.6 0.2 0.2 0.7
Chronotype (morning person) 0.6 1.4 2.2 -1.5 0.8 -1.1
Hair Pigment 0.0 0.9 2.4 -0.0 -1.5 0.5
Tanning 0.1 1.3 3.1 -0.0 0.9 -1.8
Hand grip strength (left) 0.8 2.2 4.3 0.9 -2.1 -1.2
Number of treatments/medications taken 1.0 1.8 5.2 2.3 0.3 0.4
Average weekly spirits intake 2.1 2.6 4.2 -1.7 1.0 -2.0
Sensitivity / hurt feelings 0.0 0.1 0.1 0.1 -0.4 0.2
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.5 0.3 -0.7 -0.1
Hearing difficulty/problems: Yes 0.5 0.7 1.7 -0.2 1.3 0.7
Relative age of first facial hair 0.2 0.4 1.0 -0.2 -0.5 1.0
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 1.8 1.2 1.3 0.1
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.6 -0.6 1.6 0.0
Ever had hysterectomy (womb removed) 0.6 0.7 1.7 0.6 0.1 1.3
Systolic blood pressure, automated reading 0.1 0.2 0.6 -0.2 -0.2 -0.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 1.6 -0.4 -1.3 -0.4
Angina 1.0 1.3 2.6 -0.2 1.6 -1.2
Medication for hormone replacement therapy 1.4 1.6 2.9 0.2 -1.7 1.4
Vitamin and mineral supplements 3.3 4.5 10.5 -3.2 0.1 -1.7
Supplements: Zinc 3.5 3.8 7.8 2.8 0.7 1.8
Medication: Co-codamol 0.9 1.1 2.6 0.3 1.6 -0.8
Medication: Metformin 0.2 0.3 0.6 -0.5 0.8 -0.3
Diabetes (father) 0.6 0.8 2.2 -1.5 0.2 -0.4
Diabetes (mother) 0.3 0.4 0.9 -1.0 -0.4 -0.2
Severe depression (siblings) 1.8 2.1 4.9 2.2 -0.9 0.6
Pack years adult smoking proportion 1.1 1.6 4.3 0.8 2.1 -0.1
Impedance of leg (right) 0.2 1.0 1.8 1.0 0.3 1.4
Leg fat-free mass (left) 0.3 1.3 2.9 0.9 1.7 -0.6
Trunk fat percentage 0.8 3.0 5.4 -1.2 2.3 -1.5
Hand grip strength (right) 1.0 2.8 6.7 1.0 -2.6 -0.8
Townsend deprivation index at recruitment 0.2 0.3 0.9 1.0 0.2 0.2
Current tobacco smoking 0.4 0.6 1.0 0.8 1.0 -0.3
Average weekly fortified wine intake 0.1 0.2 0.4 0.6 0.1 0.3
Maternal smoking around birth 1.5 2.2 6.5 0.1 2.5 -0.2
Fed-up feelings 0.3 0.6 1.0 0.7 1.0 0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.0 1.0 0.5 0.6
Relative age voice broke 1.2 1.8 5.4 -0.1 0.3 2.3
Taking other prescription medications 0.5 0.8 2.2 1.5 0.4 -0.0
Age when periods started (menarche) 0.4 0.9 2.6 -0.3 -1.6 -0.2
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.8 0.5 0.2 0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.1 2.5 4.5 -1.7 -0.2 -2.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.7 -0.2 1.0 1.6
Qualifications: CSEs or equivalent 0.1 0.1 0.3 -0.1 -0.2 -0.6
Serious illness, injury or assault to yourself 1.3 1.5 3.6 -1.0 -0.2 -1.9
High blood pressure 0.2 0.6 1.0 -1.0 0.2 -0.9
Hayfever, allergic rhinitis or eczema 2.4 5.2 11.9 1.7 -3.5 0.8
Multivitamins +/- minerals 1.0 1.3 3.2 1.8 -0.7 -0.3
Stomach or abdominal pain in last month 0.4 0.4 0.7 -0.8 0.2 -0.8
Supplements: Glucosamine 0.5 0.6 1.6 0.4 0.2 1.3
Diverticular disease/diverticulitis (self-reported) 2.7 3.2 9.2 -0.6 -3.0 -0.2
Medication: Atenolol 0.1 0.1 0.3 0.1 0.0 -0.6
Medication: Levothyroxine sodium 1.3 2.3 3.2 1.8 1.0 1.6
Sitting height 1.7 12.1 23.4 4.8 2.2 2.9
Chronic bronchitis/emphysema (father) 0.3 0.4 0.9 -0.4 0.3 -0.9
High blood pressure (mother) 0.3 0.4 1.1 -0.1 0.2 1.1
Body mass index (BMI) 1.4 6.1 8.7 -2.2 2.2 -3.0
Impedance of leg (left) 0.1 0.7 1.3 0.8 0.3 1.1
Leg predicted mass (left) 0.2 1.2 2.4 0.9 1.6 -0.6
Trunk fat mass 0.7 3.1 6.2 -0.7 2.5 -1.6
Waist circumference 0.8 3.1 4.4 -1.4 1.7 -2.1
Number of incorrect matches in round 0.1 0.1 0.3 0.2 -0.6 -0.1
Past tobacco smoking 0.4 0.8 0.9 -0.7 1.0 -0.9
Alcohol usually taken with meals 0.1 0.2 0.5 0.7 -0.2 0.2
Nervous feelings 0.4 0.8 1.8 -0.2 0.7 1.4
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.5 0.1 0.7 -0.3
Hearing difficulty/problems with background noise 0.7 1.1 2.2 0.2 1.5 1.0
Hair/balding pattern: Pattern 2 0.3 0.4 1.2 1.1 -0.2 0.1
Had menopause 0.2 0.2 0.6 -0.8 0.2 -0.3
Had other major operations 0.2 0.2 0.6 -0.2 0.3 0.8
Forced vital capacity (FVC) 0.9 3.4 7.1 2.7 -0.6 1.7
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.4 2.5 -1.6 -0.3 -1.2
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.3 0.5 -0.6 -0.3
Qualifications: None of the above 0.4 0.9 1.4 -0.9 0.6 -1.2
Financial difficulties in last 2 years 0.1 0.1 0.2 -0.2 -0.2 -0.5
Mouth/teeth dental problems 0.6 0.9 2.2 0.5 1.5 0.4
Heart attack 0.2 0.2 0.4 -0.4 0.6 0.3
Allergy 0.8 1.9 4.5 -0.8 2.1 0.7
Pain all over the body in last month 1.1 1.2 2.5 0.9 -0.4 1.6
Diabetes (self-reported) 0.3 0.4 1.1 0.3 0.4 1.0
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 6.2 2.5 -1.0 1.2
Medication: Ramipril 0.7 0.9 1.6 -0.6 -1.3 -0.7
Medication: Simvastatin 0.3 0.4 1.2 -0.3 -0.1 -1.1
Fluid intelligence score 0.1 0.2 0.4 -0.5 0.3 -0.6
Illnesses of siblings 0.4 0.5 1.6 0.0 -1.3 0.1
Neuroticism score 0.6 1.2 3.1 0.7 0.0 1.8
Weight 0.7 3.7 8.0 -0.0 2.8 -1.7
Impedance of arm (right) 0.6 2.6 5.5 1.4 -0.6 2.3
Arm fat percentage (right) 1.2 4.7 5.4 -2.0 2.3 -2.1
Trunk fat-free mass 0.3 1.9 2.9 1.6 1.7 -0.2
Hip circumference 0.6 2.7 4.9 -0.4 2.2 -1.8
Time employed in main current job 0.2 0.2 0.5 0.0 -0.4 -0.7
Alcohol intake versus 10 years previously 0.7 1.1 1.6 -0.4 1.2 -1.2
Father’s age at death 0.3 0.4 1.1 0.0 -1.1 0.0
Worrier / anxious feelings 1.0 1.8 5.3 0.3 0.3 2.3
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.3 3.5 1.9 0.3 0.4
Falls in the last year 0.9 1.2 2.2 -1.5 0.3 -1.2
Hair/balding pattern: Pattern 3 3.3 4.9 11.2 -3.4 -0.2 -1.9
Number of live births 0.6 0.8 2.4 -0.1 1.6 0.2
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.3 1.1 -0.8 1.0
Pulse rate 0.9 1.5 2.2 -1.1 -1.5 -1.0
Happiness 0.0 0.1 0.1 0.3 -0.0 -0.2
Noisy workplace 0.1 0.2 0.4 0.3 -0.6 -0.1
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.5 -1.9 -0.2 0.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.8 0.3 -1.7 -1.2
Mouth/teeth dental problems: Dentures 0.3 0.6 0.9 -1.0 0.8 0.3
Asthma 1.1 2.1 4.7 -1.3 -0.0 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.0 0.0 0.0 0.2 0.1 -0.1
Medication: Cholesterol lowering 0.5 0.8 1.8 -0.8 0.2 -1.4
Depression (self-reported) 0.4 0.5 0.7 0.8 0.3 0.8
Medication: Lansoprazole 0.3 0.3 0.7 0.8 -0.4 -0.4
Prospective memory result 0.3 0.4 1.0 -1.0 0.5 -0.1
Lung cancer (father) 1.2 1.4 2.9 1.2 -0.2 1.7
Illnesses of mother 1.4 1.7 3.1 -1.4 0.0 -1.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 1.5 1.2 -0.6 1.0
Pulse wave Arterial Stiffness index 0.5 0.6 1.7 1.3 0.1 -0.2
Impedance of arm (left) 0.7 3.4 6.7 1.7 -0.9 2.6
Arm fat mass (right) 1.1 4.7 7.2 -1.4 2.7 -2.2
Trunk predicted mass 0.3 1.9 3.0 1.7 1.7 -0.2
Standing height 1.0 9.5 21.3 4.6 1.6 2.2
Length of working week for main job 0.3 0.3 0.7 -0.5 0.3 -0.8
Exposure to tobacco smoke at home 1.2 1.3 2.0 -1.3 -1.4 0.4
Breastfed as a baby 0.9 1.1 2.3 1.1 -0.1 1.5
Tense / ‘highly strung’ 2.0 3.3 4.9 2.2 0.2 2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.5 0.4 -1.2 0.5
Hair/balding pattern: Pattern 4 1.1 2.6 5.6 -1.5 -2.4 -0.3
Birth weight of first child 0.8 1.4 2.5 0.4 1.3 1.6
Peak expiratory flow (PEF) 0.1 0.3 0.9 -0.1 -0.9 0.1
Pulse wave reflection index 0.8 1.0 2.4 1.6 0.5 0.7
Ever highly irritable/argumentative for 2 days 1.2 1.4 2.9 0.5 -1.7 1.1
Loud music exposure frequency 0.3 0.3 0.7 -0.2 0.5 -0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.1 -1.1 0.6 -0.8
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.4 -0.9 -1.6 -1.2
Blood clot in the leg (DVT) 1.0 1.3 2.4 -1.0 -0.7 -1.6
Medication: Paracetamol 0.9 1.5 4.3 0.1 -0.5 -2.1
Headache pain in last month 0.4 0.7 1.3 0.1 -0.9 -1.2
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 2.4 0.7 -0.1 1.6
Glaucoma (self-reported) 0.2 0.2 0.5 0.7 -0.4 0.2
Gout (self-reported) 0.1 0.1 0.2 0.2 -0.3 0.4
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 3.2 1.5 1.8 1.6
Medication: Amlodipine 0.7 1.0 3.1 0.0 -0.0 -1.8
Medication: Ventolin 100micrograms inhaler 2.5 3.2 5.2 -1.4 -2.3 -1.6
Birth weight 0.6 1.4 3.8 0.7 -1.9 -0.1
Chronic bronchitis/emphysema (mother) 0.9 1.0 2.8 -0.0 -1.7 -0.6
High blood pressure (siblings) 0.6 0.9 1.4 -0.5 1.2 -1.0
Forced vital capacity (FVC), Best measure 0.6 2.1 5.2 2.3 -0.4 0.9
Body fat percentage 1.2 4.7 6.2 -1.9 2.5 -2.1
Leg fat percentage (right) 2.0 7.2 9.2 -2.7 2.2 -3.0
Arm fat-free mass (right) 0.5 2.5 6.3 1.0 2.5 -0.6
Exposure to tobacco smoke outside home 0.5 0.7 1.1 -1.0 -0.8 -0.7
Comparative body size at age 10 0.2 0.6 1.4 0.4 0.5 -1.2
Number of full brothers 1.3 1.7 3.8 -0.3 -1.9 1.0
Worry too long after embarrassment 0.1 0.1 0.2 -0.3 -0.4 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.1 0.6 0.0
Wheeze or whistling in the chest in last year 0.5 0.9 2.5 -0.1 -0.5 -1.6
Number of children fathered 1.0 1.1 1.8 -0.9 1.3 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.4 1.9 1.4 0.7 1.3
Age at first live birth 0.4 0.7 1.3 0.9 0.0 1.2
Pulse wave peak to peak time 0.3 0.3 0.8 -0.9 -0.2 0.4
Health satisfaction 2.0 2.6 4.4 -1.6 1.0 -2.1
Shortness of breath walking on level ground 3.6 4.3 5.3 -2.0 1.9 -2.3
Qualifications: College or University degree 0.1 0.2 0.5 0.2 -0.2 0.7
Eye problems/disorders: None of the above 0.6 0.7 1.2 -0.8 1.1 0.5
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.4 -1.2 0.6 -0.1
Emphysema/chronic bronchitis 0.1 0.1 0.4 0.6 0.0 -0.0
Medication for pain relief, constipation, heartburn 0.7 1.2 3.1 0.3 0.7 1.8
Neck or shoulder pain in last month 1.4 2.1 4.1 -1.4 0.3 -2.0
Medication: Blood pressure 0.5 0.8 1.5 -0.9 0.2 -1.2
Angina (self-reported) 1.1 1.5 3.3 0.1 1.8 -1.1
Migraine (self-reported) 0.5 0.7 0.8 0.9 -0.9 -0.7
Medication: Ibuprofen 0.1 0.2 0.5 0.1 0.1 0.7
Medication: Allopurinol 0.1 0.1 0.1 0.3 0.0 -0.3
Medication: Omeprazole 0.1 0.1 0.2 -0.3 -0.4 -0.1
Medication: Seretide 50 evohaler 0.2 0.2 0.3 0.3 -0.5 -0.4
Mean time to correctly identify matches 0.4 0.7 1.8 -0.4 0.3 -1.4
Heart disease (mother) 0.5 0.6 1.0 0.4 1.0 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.1 0.2 0.0 -0.4 -0.3
Whole body fat mass 1.1 4.7 7.6 -1.2 2.8 -2.2
Leg fat mass (right) 1.7 6.6 8.7 -2.0 2.6 -3.0
Arm predicted mass (right) 0.5 2.7 6.5 1.2 2.5 -0.4
Pulse rate, automated reading 0.6 1.9 2.7 -1.5 -1.6 -0.8
Alcohol intake frequency. 0.1 0.3 0.8 -0.0 0.9 -0.4
Comparative height size at age 10 0.9 4.8 13.0 3.6 0.2 1.1
Number of full sisters 0.5 0.6 1.4 0.1 -0.7 1.2
Suffer from ‘nerves’ 0.7 1.1 1.7 -0.8 1.3 1.0
Overall health rating 0.7 1.5 2.8 -0.4 1.3 -1.7
Chest pain or discomfort 0.5 0.7 1.3 -0.1 0.9 -1.2
Had major operations 0.2 0.3 0.8 0.9 0.1 -0.2
Age at last live birth 0.4 0.6 0.9 0.9 0.2 0.9
Family relationship satisfaction 0.1 0.1 0.3 -0.0 0.1 0.6
Leg pain on walking 2.2 2.7 4.6 -1.5 -1.1 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.8 0.9 2.6 -0.1 -1.6 -0.3
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.3 0.8 -1.2 -0.1
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 6.5 0.4 1.8 2.5
Medication: Aspirin 0.6 0.9 1.7 -0.5 -0.8 -1.3
Supplements: Vitamin C 2.6 3.1 6.6 1.6 -0.4 2.6
Knee pain experienced in last month 0.6 1.0 1.8 -1.0 -1.3 0.5
Hypertension (Self-reported) 0.3 0.9 1.6 -1.3 -0.3 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.1 -0.3 -0.1 -0.3
Illnesses of father: Heart disease 1.2 1.7 4.1 -0.1 2.0 1.0
Illnesses of siblings: Diabetes 1.0 1.2 3.1 -0.3 1.8 -0.7
Smoking status: Previous 1.1 1.7 2.9 1.1 -1.0 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.6 1.2 3.3 0.5 1.8 0.2
Whole body fat-free mass 0.3 1.7 3.1 1.3 1.8 -0.5
Leg fat-free mass (right) 0.2 1.1 2.1 0.9 1.5 -0.6
Arm fat percentage (left) 0.9 3.8 5.2 -1.6 2.3 -1.9
Average weekly red wine intake 0.2 0.3 0.5 0.6 0.2 -0.7
Handedness (chirality/laterality): Left-handed 1.4 1.7 3.7 -0.1 -1.2 -1.9
Mood swings 0.0 0.0 0.1 0.1 -0.2 0.3
Loneliness, isolation 0.1 0.1 0.2 0.3 0.2 0.4
Long-standing illness, disability or infirmity 0.6 1.0 2.7 0.2 0.4 -1.6
Ever had bowel cancer screening 0.5 0.5 1.3 -0.3 -0.5 -1.2
Diabetes diagnosed by doctor 0.1 0.2 0.3 -0.4 0.6 0.5
Ever had stillbirth, spontaneous miscarriage or termination 4.0 4.3 6.8 2.6 -0.3 2.5
Friendships satisfaction 0.3 0.4 0.6 -0.5 0.5 -0.8
Qualifications: nursing, teaching 0.1 0.1 0.2 -0.3 0.4 0.4
Commuting to job workplace: Walk 0.9 1.0 1.8 -1.3 0.4 -1.0
Eye problems/disorders: Cataract 0.0 0.1 0.1 0.2 0.0 -0.3
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.1 1.1 -1.0 -0.5
Medication for cholesterol 0.6 0.9 1.4 -1.2 0.7 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 2.4 1.0 -0.4 1.6
Back pain experienced in last month 0.8 1.1 1.4 1.2 0.8 -1.2
Mineral and other dietary supplements 1.9 2.5 6.3 -2.5 -0.5 -1.0
Breast cancer (self-reported) 0.5 0.6 1.2 0.8 0.3 1.1
Asthma (self-reported) 1.1 2.2 4.9 -1.3 0.3 -2.2
Osteoporosis (self-reported) 0.8 1.0 2.4 -0.7 -0.5 -1.5
Osteoarthritis (self-reported) 0.4 0.5 1.0 -0.5 0.5 -1.0
Medication: Aspirin 0.7 0.9 1.7 -0.3 -0.9 -1.3
Medication: Gliclazide 0.5 0.6 1.5 -0.5 0.2 -1.2
Illnesses of father: None of the above (group 1) 0.7 0.9 1.0 0.9 -1.0 -0.9
Smoking status: Current 0.4 0.7 1.3 1.1 0.8 -0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 6.2 -0.2 -2.5 -0.3
Whole body water mass 0.3 1.9 3.6 1.3 1.9 -0.5
Leg predicted mass (right) 0.2 1.2 2.4 1.0 1.5 -0.6
Arm fat mass (left) 1.0 4.0 6.8 -1.1 2.6 -2.0
Number of self-reported non-cancer illnesses 0.7 1.3 3.6 -0.4 0.1 -1.9
Average weekly champagne plus white wine intake 0.7 1.0 2.1 1.4 -0.4 0.9
Miserableness 0.1 0.2 0.4 -0.3 0.7 0.2
Guilty feelings 0.7 1.1 2.8 -0.5 -1.7 -0.5
Wears glasses or contact lenses 0.1 0.1 0.2 -0.0 0.3 -0.4
Ever taken oral contraceptive pill 0.9 1.0 1.7 -0.1 1.2 1.3
Hearing aid user 0.5 0.6 0.8 -0.3 0.9 -0.9
Mother’s age at death 0.9 1.1 1.8 -0.3 -1.2 1.3
Financial situation satisfaction 0.7 0.9 2.4 -0.4 0.2 -1.5
Tinnitus: Yes, now most or all of the time 0.5 0.6 0.9 0.4 0.9 -0.9
Commuting to job workplace: Public transport 0.1 0.1 0.3 0.5 0.2 0.0
Eye problems/disorders: Glaucoma 0.7 0.9 1.7 1.3 -0.1 1.0
Medication: Blood pressure 0.1 0.1 0.2 0.5 0.0 -0.3
Pain type(s) experienced in last month: Hip pain 0.7 0.9 1.9 -0.6 0.6 -1.4
Supplements: Fish oil (including cod liver oil) 2.7 3.5 8.8 3.0 0.8 1.0
High cholesterol (Self-reported) 0.5 0.8 2.2 0.5 1.5 0.0
Medication: Bendroflumethiazide 0.2 0.3 0.7 -0.3 0.9 -0.0
Medication: Paracetamol 0.3 0.4 0.7 0.6 0.2 -0.9
Medication: Lisinopril 0.6 0.8 1.3 0.7 1.1 0.7
Medication: Atorvastatin 1.4 1.7 3.6 -0.9 -0.9 -1.9
Illnesses of father: High blood pressure 0.5 0.6 1.5 -0.5 -1.2 0.4
Alcohol drinker status: Never 1.3 1.5 4.3 2.1 0.5 0.1
Ever smoked 0.4 0.7 1.5 0.8 -1.2 0.3
Basal metabolic rate 0.4 2.1 4.5 1.1 2.1 -0.8
Leg fat percentage (left) 2.1 7.7 10.1 -2.8 2.3 -3.2
Arm fat-free mass (left) 0.6 2.8 7.5 0.7 2.7 -0.7
Number of operations (self-reported) 0.2 0.3 0.5 0.7 0.7 0.2
Average weekly beer plus cider intake 0.5 0.7 1.3 1.1 -0.6 0.8
Irritability 0.8 1.3 2.4 0.7 -1.5 1.0
Risk taking 2.1 3.0 6.9 2.6 -0.7 1.3
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.1 0.7 -0.1 1.0
Fractured/broken bones in last 5 years 0.3 0.3 0.7 -0.1 0.6 0.8
Age started oral contraceptive pill 0.1 0.1 0.3 -0.1 0.3 0.5
Diastolic blood pressure, automated reading 0.1 0.2 0.4 -0.4 0.6 -0.2
Ever depressed for a whole week 0.9 1.1 1.4 -0.7 -1.2 -1.2
Unable to work because of sickness or disability 1.9 2.5 3.7 -1.8 -0.7 -1.9
Commuting to job workplace: Cycle 0.8 1.0 2.7 0.5 1.6 -0.0
Myopia 0.7 1.0 2.4 -0.7 1.6 0.5
Vascular/heart problems diagnosed by doctor 0.1 0.3 0.6 0.3 -0.8 0.5
Cholesterol lowering medication 0.1 0.2 0.6 0.8 0.1 -0.0
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.6 0.8 -0.8 0.7
Pain experienced in last month 0.6 1.0 2.5 0.6 0.4 1.6
Supplements: Calcium 0.8 0.9 1.7 1.3 0.9 0.6
Basal cell carcinoma (self-reported) 0.9 1.0 1.5 -1.1 0.7 -1.2
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.5 -0.5 0.7 0.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.1 -0.4 -0.7 -1.0
Heart disease (siblings) 0.0 0.0 0.1 0.3 0.2 -0.0
Alcohol drinker status: Previous 0.5 0.5 1.4 -0.3 -0.4 -1.2
Pack years of smoking 0.8 1.1 3.1 0.4 1.8 -0.3
Impedance of whole body 0.4 1.9 4.0 1.2 -0.5 2.0
Leg fat mass (left) 1.8 6.9 8.9 -1.9 2.8 -3.0
Arm predicted mass (left) 0.6 3.3 8.6 0.6 2.9 -0.9