Hub : Genes

RHOQ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0694	0.0273	0.0020	0.009	0.018	0.027	0.022	0.015	2.4e-02	0.0017	0.00016	0.0007	0.00460
2	YFS	Blood	0.0296	0.0126	0.0081	0.006	0.004	0.005	0.006	0.006	4.0e-03	0.0110	0.00950	0.0036	0.00340
3	TCGA	Thyroid Carcinoma	0.0680	0.0370	0.0078	0.044	0.018	0.023	NA	0.035	3.6e-05	0.0068	0.00240	NA	0.00023

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.4	0.4	-1.2	0.6
Bipolar Disorder or Schizophrenia	0.6	1.4	2.5	-0.2	-1.6	1.3
Depressed Affect (Nagel 2018)	0.4	0.8	1.2	1.1	1.0	0.4
Depression (Nagel 2018)	0.3	0.5	0.7	0.8	-0.8	0.4
Intelligence (Savage-Jansen 2018)	0.3	0.8	1.6	-1.2	0.0	-0.9
Neuroticism (Nagel 2018)	0.2	0.5	0.9	0.7	0.1	1.0
Schizophrenia (2018)	0.5	0.9	1.4	-0.5	-1.1	1.2
Schizophrenia vs Biploar Disorder	0.5	0.7	1.9	-1.4	0.5	-0.2
Worry (Nagel 2018)	0.4	0.7	2.2	-0.2	0.1	1.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	0.2	0.3	0.4
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.1	0.3	-0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.3	0.0	0.6	-0.0
Crohns Disease (2017)	0.5	1.0	1.9	1.4	0.3	1.0
Irritable Bowel Disease (IBD)	0.0	0.0	0.0	0.0	-0.1	0.0
Ulcerative Colitis (UC)	0.3	0.5	0.9	-0.8	-0.2	-1.0
Major Depression (MDD)	0.7	0.8	1.7	0.8	0.0	-1.3
Reaction Time	0.1	0.2	0.5	0.1	-0.3	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-0.4	1.1	-0.1
Breast Cancer	0.3	0.7	1.6	-1.2	-0.6	-0.3
Ovarian Cancer	0.1	0.1	0.3	0.1	0.5	-0.0
Prostate Cancer	1.5	2.2	3.4	-1.8	0.0	-1.8
Age at First Birth	1.0	1.4	4.1	-0.3	-2.0	-0.4
Bipolar Disorder (2011)	1.0	1.0	2.7	1.6	0.5	-0.1
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.4	0.0	-0.6
Coronary Artery Disease (CAD)	1.6	1.9	2.6	1.2	1.6	1.3
Crohns Disease (2012)	0.1	0.2	0.3	0.6	-0.2	0.5
Mean Putamen Volume	0.1	0.1	0.1	-0.3	0.4	-0.3
Fasting Glucose	0.3	0.4	0.7	0.9	-0.5	-0.4
HbA1C	0.4	0.5	0.8	0.7	-0.1	0.9
HDL Cholesterol	0.4	0.6	0.9	-0.7	-0.7	0.9
LDL Cholesterol	0.8	1.2	2.8	-1.7	0.0	-0.9
Lupus	0.7	1.1	2.9	-0.3	-1.7	-0.5
Neuroticism (2016)	0.6	0.8	2.4	0.3	1.6	0.2
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.1	-0.1	0.3
Rheumatoid Arthritis	0.5	0.7	1.0	-0.4	-1.0	-1.0
Schizophrenia (2014)	0.3	0.7	1.2	-0.1	-1.0	1.1
Triglycerides	0.4	0.6	1.4	0.6	0.3	1.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.8	-0.3	0.1
Ulcerative Colitis	0.3	0.4	0.9	-0.9	-0.0	-0.7
Blood Eosinophil Count	0.5	4.1	8.2	1.9	2.9	0.5
Blood Platelet Count	0.4	4.4	5.5	-1.9	-2.0	-2.4
Blood Red Count	0.3	2.8	5.2	2.3	0.6	1.7
Blood White Count	0.4	2.9	6.3	-2.5	0.4	-1.5
Heel T-Score	0.4	2.9	6.8	-1.2	-0.6	-2.6
BMI	1.2	7.2	9.5	-2.3	3.1	-2.6
Height	1.0	19.5	45.0	6.7	1.9	3.2
Waist Hip Ratio (WHR)	0.0	0.1	0.1	0.3	-0.3	-0.0
Systolic Blood Pressure	0.2	1.0	1.9	0.8	-0.6	1.4
Smoking Status	1.5	3.6	6.9	2.6	0.8	1.8
Allergy or Eczema	1.7	4.5	11.6	1.4	-3.4	-0.1
Cardiovascular Disease	0.2	0.8	1.4	-0.9	1.2	-0.3
Hypothyroidism (self reported)	0.8	1.8	3.5	0.4	1.9	1.2
Respiratory disease	0.7	1.5	2.6	-0.1	1.4	-1.6
Type 2 Diabetes (T2D) (2018)	0.8	1.5	2.5	-1.6	-0.7	-1.3
Lung FEV1/FVC ratio	0.6	3.2	9.1	-3.0	0.2	-0.7
Lung FVC	0.8	3.9	10.8	-0.4	-3.3	-0.9
Neuroticism	0.1	0.2	0.6	0.2	0.2	0.7
Chronotype (morning person)	0.6	1.4	2.2	-1.5	0.8	-1.1
Hair Pigment	0.0	0.9	2.4	-0.0	-1.5	0.5
Tanning	0.1	1.3	3.1	-0.0	0.9	-1.8
Hand grip strength (left)	0.8	2.2	4.3	0.9	-2.1	-1.2
Number of treatments/medications taken	1.0	1.8	5.2	2.3	0.3	0.4
Average weekly spirits intake	2.1	2.6	4.2	-1.7	1.0	-2.0
Sensitivity / hurt feelings	0.0	0.1	0.1	0.1	-0.4	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.5	0.3	-0.7	-0.1
Hearing difficulty/problems: Yes	0.5	0.7	1.7	-0.2	1.3	0.7
Relative age of first facial hair	0.2	0.4	1.0	-0.2	-0.5	1.0
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.8	1.2	1.3	0.1
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.6	-0.6	1.6	0.0
Ever had hysterectomy (womb removed)	0.6	0.7	1.7	0.6	0.1	1.3
Systolic blood pressure, automated reading	0.1	0.2	0.6	-0.2	-0.2	-0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.6	-0.4	-1.3	-0.4
Angina	1.0	1.3	2.6	-0.2	1.6	-1.2
Medication for hormone replacement therapy	1.4	1.6	2.9	0.2	-1.7	1.4
Vitamin and mineral supplements	3.3	4.5	10.5	-3.2	0.1	-1.7
Supplements: Zinc	3.5	3.8	7.8	2.8	0.7	1.8
Medication: Co-codamol	0.9	1.1	2.6	0.3	1.6	-0.8
Medication: Metformin	0.2	0.3	0.6	-0.5	0.8	-0.3
Diabetes (father)	0.6	0.8	2.2	-1.5	0.2	-0.4
Diabetes (mother)	0.3	0.4	0.9	-1.0	-0.4	-0.2
Severe depression (siblings)	1.8	2.1	4.9	2.2	-0.9	0.6
Pack years adult smoking proportion	1.1	1.6	4.3	0.8	2.1	-0.1
Impedance of leg (right)	0.2	1.0	1.8	1.0	0.3	1.4
Leg fat-free mass (left)	0.3	1.3	2.9	0.9	1.7	-0.6
Trunk fat percentage	0.8	3.0	5.4	-1.2	2.3	-1.5
Hand grip strength (right)	1.0	2.8	6.7	1.0	-2.6	-0.8
Townsend deprivation index at recruitment	0.2	0.3	0.9	1.0	0.2	0.2
Current tobacco smoking	0.4	0.6	1.0	0.8	1.0	-0.3
Average weekly fortified wine intake	0.1	0.2	0.4	0.6	0.1	0.3
Maternal smoking around birth	1.5	2.2	6.5	0.1	2.5	-0.2
Fed-up feelings	0.3	0.6	1.0	0.7	1.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.0	1.0	0.5	0.6
Relative age voice broke	1.2	1.8	5.4	-0.1	0.3	2.3
Taking other prescription medications	0.5	0.8	2.2	1.5	0.4	-0.0
Age when periods started (menarche)	0.4	0.9	2.6	-0.3	-1.6	-0.2
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	0.5	0.2	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.5	4.5	-1.7	-0.2	-2.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.7	-0.2	1.0	1.6
Qualifications: CSEs or equivalent	0.1	0.1	0.3	-0.1	-0.2	-0.6
Serious illness, injury or assault to yourself	1.3	1.5	3.6	-1.0	-0.2	-1.9
High blood pressure	0.2	0.6	1.0	-1.0	0.2	-0.9
Hayfever, allergic rhinitis or eczema	2.4	5.2	11.9	1.7	-3.5	0.8
Multivitamins +/- minerals	1.0	1.3	3.2	1.8	-0.7	-0.3
Stomach or abdominal pain in last month	0.4	0.4	0.7	-0.8	0.2	-0.8
Supplements: Glucosamine	0.5	0.6	1.6	0.4	0.2	1.3
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	9.2	-0.6	-3.0	-0.2
Medication: Atenolol	0.1	0.1	0.3	0.1	0.0	-0.6
Medication: Levothyroxine sodium	1.3	2.3	3.2	1.8	1.0	1.6
Sitting height	1.7	12.1	23.4	4.8	2.2	2.9
Chronic bronchitis/emphysema (father)	0.3	0.4	0.9	-0.4	0.3	-0.9
High blood pressure (mother)	0.3	0.4	1.1	-0.1	0.2	1.1
Body mass index (BMI)	1.4	6.1	8.7	-2.2	2.2	-3.0
Impedance of leg (left)	0.1	0.7	1.3	0.8	0.3	1.1
Leg predicted mass (left)	0.2	1.2	2.4	0.9	1.6	-0.6
Trunk fat mass	0.7	3.1	6.2	-0.7	2.5	-1.6
Waist circumference	0.8	3.1	4.4	-1.4	1.7	-2.1
Number of incorrect matches in round	0.1	0.1	0.3	0.2	-0.6	-0.1
Past tobacco smoking	0.4	0.8	0.9	-0.7	1.0	-0.9
Alcohol usually taken with meals	0.1	0.2	0.5	0.7	-0.2	0.2
Nervous feelings	0.4	0.8	1.8	-0.2	0.7	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.1	0.7	-0.3
Hearing difficulty/problems with background noise	0.7	1.1	2.2	0.2	1.5	1.0
Hair/balding pattern: Pattern 2	0.3	0.4	1.2	1.1	-0.2	0.1
Had menopause	0.2	0.2	0.6	-0.8	0.2	-0.3
Had other major operations	0.2	0.2	0.6	-0.2	0.3	0.8
Forced vital capacity (FVC)	0.9	3.4	7.1	2.7	-0.6	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	2.5	-1.6	-0.3	-1.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.5	-0.6	-0.3
Qualifications: None of the above	0.4	0.9	1.4	-0.9	0.6	-1.2
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.2	-0.2	-0.5
Mouth/teeth dental problems	0.6	0.9	2.2	0.5	1.5	0.4
Heart attack	0.2	0.2	0.4	-0.4	0.6	0.3
Allergy	0.8	1.9	4.5	-0.8	2.1	0.7
Pain all over the body in last month	1.1	1.2	2.5	0.9	-0.4	1.6
Diabetes (self-reported)	0.3	0.4	1.1	0.3	0.4	1.0
Hayfever/allergic rhinitis (self-reported)	2.2	2.9	6.2	2.5	-1.0	1.2
Medication: Ramipril	0.7	0.9	1.6	-0.6	-1.3	-0.7
Medication: Simvastatin	0.3	0.4	1.2	-0.3	-0.1	-1.1
Fluid intelligence score	0.1	0.2	0.4	-0.5	0.3	-0.6
Illnesses of siblings	0.4	0.5	1.6	0.0	-1.3	0.1
Neuroticism score	0.6	1.2	3.1	0.7	0.0	1.8
Weight	0.7	3.7	8.0	-0.0	2.8	-1.7
Impedance of arm (right)	0.6	2.6	5.5	1.4	-0.6	2.3
Arm fat percentage (right)	1.2	4.7	5.4	-2.0	2.3	-2.1
Trunk fat-free mass	0.3	1.9	2.9	1.6	1.7	-0.2
Hip circumference	0.6	2.7	4.9	-0.4	2.2	-1.8
Time employed in main current job	0.2	0.2	0.5	0.0	-0.4	-0.7
Alcohol intake versus 10 years previously	0.7	1.1	1.6	-0.4	1.2	-1.2
Father’s age at death	0.3	0.4	1.1	0.0	-1.1	0.0
Worrier / anxious feelings	1.0	1.8	5.3	0.3	0.3	2.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	3.5	1.9	0.3	0.4
Falls in the last year	0.9	1.2	2.2	-1.5	0.3	-1.2
Hair/balding pattern: Pattern 3	3.3	4.9	11.2	-3.4	-0.2	-1.9
Number of live births	0.6	0.8	2.4	-0.1	1.6	0.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.3	1.1	-0.8	1.0
Pulse rate	0.9	1.5	2.2	-1.1	-1.5	-1.0
Happiness	0.0	0.1	0.1	0.3	-0.0	-0.2
Noisy workplace	0.1	0.2	0.4	0.3	-0.6	-0.1
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.5	-1.9	-0.2	0.0
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.8	0.3	-1.7	-1.2
Mouth/teeth dental problems: Dentures	0.3	0.6	0.9	-1.0	0.8	0.3
Asthma	1.1	2.1	4.7	-1.3	-0.0	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.0	0.2	0.1	-0.1
Medication: Cholesterol lowering	0.5	0.8	1.8	-0.8	0.2	-1.4
Depression (self-reported)	0.4	0.5	0.7	0.8	0.3	0.8
Medication: Lansoprazole	0.3	0.3	0.7	0.8	-0.4	-0.4
Prospective memory result	0.3	0.4	1.0	-1.0	0.5	-0.1
Lung cancer (father)	1.2	1.4	2.9	1.2	-0.2	1.7
Illnesses of mother	1.4	1.7	3.1	-1.4	0.0	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.5	1.2	-0.6	1.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	1.3	0.1	-0.2
Impedance of arm (left)	0.7	3.4	6.7	1.7	-0.9	2.6
Arm fat mass (right)	1.1	4.7	7.2	-1.4	2.7	-2.2
Trunk predicted mass	0.3	1.9	3.0	1.7	1.7	-0.2
Standing height	1.0	9.5	21.3	4.6	1.6	2.2
Length of working week for main job	0.3	0.3	0.7	-0.5	0.3	-0.8
Exposure to tobacco smoke at home	1.2	1.3	2.0	-1.3	-1.4	0.4
Breastfed as a baby	0.9	1.1	2.3	1.1	-0.1	1.5
Tense / ‘highly strung’	2.0	3.3	4.9	2.2	0.2	2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	0.4	-1.2	0.5
Hair/balding pattern: Pattern 4	1.1	2.6	5.6	-1.5	-2.4	-0.3
Birth weight of first child	0.8	1.4	2.5	0.4	1.3	1.6
Peak expiratory flow (PEF)	0.1	0.3	0.9	-0.1	-0.9	0.1
Pulse wave reflection index	0.8	1.0	2.4	1.6	0.5	0.7
Ever highly irritable/argumentative for 2 days	1.2	1.4	2.9	0.5	-1.7	1.1
Loud music exposure frequency	0.3	0.3	0.7	-0.2	0.5	-0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.1	-1.1	0.6	-0.8
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.4	-0.9	-1.6	-1.2
Blood clot in the leg (DVT)	1.0	1.3	2.4	-1.0	-0.7	-1.6
Medication: Paracetamol	0.9	1.5	4.3	0.1	-0.5	-2.1
Headache pain in last month	0.4	0.7	1.3	0.1	-0.9	-1.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	2.4	0.7	-0.1	1.6
Glaucoma (self-reported)	0.2	0.2	0.5	0.7	-0.4	0.2
Gout (self-reported)	0.1	0.1	0.2	0.2	-0.3	0.4
Hypothyroidism/myxoedema (self-reported)	1.4	2.7	3.2	1.5	1.8	1.6
Medication: Amlodipine	0.7	1.0	3.1	0.0	-0.0	-1.8
Medication: Ventolin 100micrograms inhaler	2.5	3.2	5.2	-1.4	-2.3	-1.6
Birth weight	0.6	1.4	3.8	0.7	-1.9	-0.1
Chronic bronchitis/emphysema (mother)	0.9	1.0	2.8	-0.0	-1.7	-0.6
High blood pressure (siblings)	0.6	0.9	1.4	-0.5	1.2	-1.0
Forced vital capacity (FVC), Best measure	0.6	2.1	5.2	2.3	-0.4	0.9
Body fat percentage	1.2	4.7	6.2	-1.9	2.5	-2.1
Leg fat percentage (right)	2.0	7.2	9.2	-2.7	2.2	-3.0
Arm fat-free mass (right)	0.5	2.5	6.3	1.0	2.5	-0.6
Exposure to tobacco smoke outside home	0.5	0.7	1.1	-1.0	-0.8	-0.7
Comparative body size at age 10	0.2	0.6	1.4	0.4	0.5	-1.2
Number of full brothers	1.3	1.7	3.8	-0.3	-1.9	1.0
Worry too long after embarrassment	0.1	0.1	0.2	-0.3	-0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.1	0.6	0.0
Wheeze or whistling in the chest in last year	0.5	0.9	2.5	-0.1	-0.5	-1.6
Number of children fathered	1.0	1.1	1.8	-0.9	1.3	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	1.9	1.4	0.7	1.3
Age at first live birth	0.4	0.7	1.3	0.9	0.0	1.2
Pulse wave peak to peak time	0.3	0.3	0.8	-0.9	-0.2	0.4
Health satisfaction	2.0	2.6	4.4	-1.6	1.0	-2.1
Shortness of breath walking on level ground	3.6	4.3	5.3	-2.0	1.9	-2.3
Qualifications: College or University degree	0.1	0.2	0.5	0.2	-0.2	0.7
Eye problems/disorders: None of the above	0.6	0.7	1.2	-0.8	1.1	0.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	-1.2	0.6	-0.1
Emphysema/chronic bronchitis	0.1	0.1	0.4	0.6	0.0	-0.0
Medication for pain relief, constipation, heartburn	0.7	1.2	3.1	0.3	0.7	1.8
Neck or shoulder pain in last month	1.4	2.1	4.1	-1.4	0.3	-2.0
Medication: Blood pressure	0.5	0.8	1.5	-0.9	0.2	-1.2
Angina (self-reported)	1.1	1.5	3.3	0.1	1.8	-1.1
Migraine (self-reported)	0.5	0.7	0.8	0.9	-0.9	-0.7
Medication: Ibuprofen	0.1	0.2	0.5	0.1	0.1	0.7
Medication: Allopurinol	0.1	0.1	0.1	0.3	0.0	-0.3
Medication: Omeprazole	0.1	0.1	0.2	-0.3	-0.4	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.3	0.3	-0.5	-0.4
Mean time to correctly identify matches	0.4	0.7	1.8	-0.4	0.3	-1.4
Heart disease (mother)	0.5	0.6	1.0	0.4	1.0	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.2	0.0	-0.4	-0.3
Whole body fat mass	1.1	4.7	7.6	-1.2	2.8	-2.2
Leg fat mass (right)	1.7	6.6	8.7	-2.0	2.6	-3.0
Arm predicted mass (right)	0.5	2.7	6.5	1.2	2.5	-0.4
Pulse rate, automated reading	0.6	1.9	2.7	-1.5	-1.6	-0.8
Alcohol intake frequency.	0.1	0.3	0.8	-0.0	0.9	-0.4
Comparative height size at age 10	0.9	4.8	13.0	3.6	0.2	1.1
Number of full sisters	0.5	0.6	1.4	0.1	-0.7	1.2
Suffer from ‘nerves’	0.7	1.1	1.7	-0.8	1.3	1.0
Overall health rating	0.7	1.5	2.8	-0.4	1.3	-1.7
Chest pain or discomfort	0.5	0.7	1.3	-0.1	0.9	-1.2
Had major operations	0.2	0.3	0.8	0.9	0.1	-0.2
Age at last live birth	0.4	0.6	0.9	0.9	0.2	0.9
Family relationship satisfaction	0.1	0.1	0.3	-0.0	0.1	0.6
Leg pain on walking	2.2	2.7	4.6	-1.5	-1.1	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	2.6	-0.1	-1.6	-0.3
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.3	0.8	-1.2	-0.1
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	6.5	0.4	1.8	2.5
Medication: Aspirin	0.6	0.9	1.7	-0.5	-0.8	-1.3
Supplements: Vitamin C	2.6	3.1	6.6	1.6	-0.4	2.6
Knee pain experienced in last month	0.6	1.0	1.8	-1.0	-1.3	0.5
Hypertension (Self-reported)	0.3	0.9	1.6	-1.3	-0.3	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	-0.3	-0.1	-0.3
Illnesses of father: Heart disease	1.2	1.7	4.1	-0.1	2.0	1.0
Illnesses of siblings: Diabetes	1.0	1.2	3.1	-0.3	1.8	-0.7
Smoking status: Previous	1.1	1.7	2.9	1.1	-1.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.3	0.5	1.8	0.2
Whole body fat-free mass	0.3	1.7	3.1	1.3	1.8	-0.5
Leg fat-free mass (right)	0.2	1.1	2.1	0.9	1.5	-0.6
Arm fat percentage (left)	0.9	3.8	5.2	-1.6	2.3	-1.9
Average weekly red wine intake	0.2	0.3	0.5	0.6	0.2	-0.7
Handedness (chirality/laterality): Left-handed	1.4	1.7	3.7	-0.1	-1.2	-1.9
Mood swings	0.0	0.0	0.1	0.1	-0.2	0.3
Loneliness, isolation	0.1	0.1	0.2	0.3	0.2	0.4
Long-standing illness, disability or infirmity	0.6	1.0	2.7	0.2	0.4	-1.6
Ever had bowel cancer screening	0.5	0.5	1.3	-0.3	-0.5	-1.2
Diabetes diagnosed by doctor	0.1	0.2	0.3	-0.4	0.6	0.5
Ever had stillbirth, spontaneous miscarriage or termination	4.0	4.3	6.8	2.6	-0.3	2.5
Friendships satisfaction	0.3	0.4	0.6	-0.5	0.5	-0.8
Qualifications: nursing, teaching	0.1	0.1	0.2	-0.3	0.4	0.4
Commuting to job workplace: Walk	0.9	1.0	1.8	-1.3	0.4	-1.0
Eye problems/disorders: Cataract	0.0	0.1	0.1	0.2	0.0	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.1	1.1	-1.0	-0.5
Medication for cholesterol	0.6	0.9	1.4	-1.2	0.7	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.4	1.0	-0.4	1.6
Back pain experienced in last month	0.8	1.1	1.4	1.2	0.8	-1.2
Mineral and other dietary supplements	1.9	2.5	6.3	-2.5	-0.5	-1.0
Breast cancer (self-reported)	0.5	0.6	1.2	0.8	0.3	1.1
Asthma (self-reported)	1.1	2.2	4.9	-1.3	0.3	-2.2
Osteoporosis (self-reported)	0.8	1.0	2.4	-0.7	-0.5	-1.5
Osteoarthritis (self-reported)	0.4	0.5	1.0	-0.5	0.5	-1.0
Medication: Aspirin	0.7	0.9	1.7	-0.3	-0.9	-1.3
Medication: Gliclazide	0.5	0.6	1.5	-0.5	0.2	-1.2
Illnesses of father: None of the above (group 1)	0.7	0.9	1.0	0.9	-1.0	-0.9
Smoking status: Current	0.4	0.7	1.3	1.1	0.8	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	6.2	-0.2	-2.5	-0.3
Whole body water mass	0.3	1.9	3.6	1.3	1.9	-0.5
Leg predicted mass (right)	0.2	1.2	2.4	1.0	1.5	-0.6
Arm fat mass (left)	1.0	4.0	6.8	-1.1	2.6	-2.0
Number of self-reported non-cancer illnesses	0.7	1.3	3.6	-0.4	0.1	-1.9
Average weekly champagne plus white wine intake	0.7	1.0	2.1	1.4	-0.4	0.9
Miserableness	0.1	0.2	0.4	-0.3	0.7	0.2
Guilty feelings	0.7	1.1	2.8	-0.5	-1.7	-0.5
Wears glasses or contact lenses	0.1	0.1	0.2	-0.0	0.3	-0.4
Ever taken oral contraceptive pill	0.9	1.0	1.7	-0.1	1.2	1.3
Hearing aid user	0.5	0.6	0.8	-0.3	0.9	-0.9
Mother’s age at death	0.9	1.1	1.8	-0.3	-1.2	1.3
Financial situation satisfaction	0.7	0.9	2.4	-0.4	0.2	-1.5
Tinnitus: Yes, now most or all of the time	0.5	0.6	0.9	0.4	0.9	-0.9
Commuting to job workplace: Public transport	0.1	0.1	0.3	0.5	0.2	0.0
Eye problems/disorders: Glaucoma	0.7	0.9	1.7	1.3	-0.1	1.0
Medication: Blood pressure	0.1	0.1	0.2	0.5	0.0	-0.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.9	-0.6	0.6	-1.4
Supplements: Fish oil (including cod liver oil)	2.7	3.5	8.8	3.0	0.8	1.0
High cholesterol (Self-reported)	0.5	0.8	2.2	0.5	1.5	0.0
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.3	0.9	-0.0
Medication: Paracetamol	0.3	0.4	0.7	0.6	0.2	-0.9
Medication: Lisinopril	0.6	0.8	1.3	0.7	1.1	0.7
Medication: Atorvastatin	1.4	1.7	3.6	-0.9	-0.9	-1.9
Illnesses of father: High blood pressure	0.5	0.6	1.5	-0.5	-1.2	0.4
Alcohol drinker status: Never	1.3	1.5	4.3	2.1	0.5	0.1
Ever smoked	0.4	0.7	1.5	0.8	-1.2	0.3
Basal metabolic rate	0.4	2.1	4.5	1.1	2.1	-0.8
Leg fat percentage (left)	2.1	7.7	10.1	-2.8	2.3	-3.2
Arm fat-free mass (left)	0.6	2.8	7.5	0.7	2.7	-0.7
Number of operations (self-reported)	0.2	0.3	0.5	0.7	0.7	0.2
Average weekly beer plus cider intake	0.5	0.7	1.3	1.1	-0.6	0.8
Irritability	0.8	1.3	2.4	0.7	-1.5	1.0
Risk taking	2.1	3.0	6.9	2.6	-0.7	1.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	0.7	-0.1	1.0
Fractured/broken bones in last 5 years	0.3	0.3	0.7	-0.1	0.6	0.8
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	0.3	0.5
Diastolic blood pressure, automated reading	0.1	0.2	0.4	-0.4	0.6	-0.2
Ever depressed for a whole week	0.9	1.1	1.4	-0.7	-1.2	-1.2
Unable to work because of sickness or disability	1.9	2.5	3.7	-1.8	-0.7	-1.9
Commuting to job workplace: Cycle	0.8	1.0	2.7	0.5	1.6	-0.0
Myopia	0.7	1.0	2.4	-0.7	1.6	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.3	-0.8	0.5
Cholesterol lowering medication	0.1	0.2	0.6	0.8	0.1	-0.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.6	0.8	-0.8	0.7
Pain experienced in last month	0.6	1.0	2.5	0.6	0.4	1.6
Supplements: Calcium	0.8	0.9	1.7	1.3	0.9	0.6
Basal cell carcinoma (self-reported)	0.9	1.0	1.5	-1.1	0.7	-1.2
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.5	0.7	0.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.1	-0.4	-0.7	-1.0
Heart disease (siblings)	0.0	0.0	0.1	0.3	0.2	-0.0
Alcohol drinker status: Previous	0.5	0.5	1.4	-0.3	-0.4	-1.2
Pack years of smoking	0.8	1.1	3.1	0.4	1.8	-0.3
Impedance of whole body	0.4	1.9	4.0	1.2	-0.5	2.0
Leg fat mass (left)	1.8	6.9	8.9	-1.9	2.8	-3.0
Arm predicted mass (left)	0.6	3.3	8.6	0.6	2.9	-0.9