Hub : Genes

RIN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0920 0.0340 0.00490 0.012 0.011 0.004 0.011 0.013 0.013 0.01500 0.0970 0.0150 0.0078
2 GTEx Artery Aorta 0.1440 0.0540 0.00650 0.010 NA 0.010 NA 0.008 0.090 NA 0.0850 NA 0.1100
3 GTEx Esophagus Mucosa 0.1170 0.0450 0.00820 0.000 NA 0.009 NA 0.004 0.310 NA 0.0780 NA 0.1700
4 YFS Blood 0.0473 0.0148 0.00013 -0.001 0.005 0.007 0.005 0.000 0.760 0.00780 0.0023 0.0084 0.5100
5 TCGA Breast Invasive Carcinoma 0.0382 0.0150 0.00190 -0.001 0.018 0.006 NA 0.000 0.650 0.00012 0.0190 NA 0.2500
6 TCGA Prostate Adenocarcinoma 0.0530 0.0233 0.00900 0.003 0.020 -0.002 NA 0.000 0.150 0.00280 0.6500 NA 0.3300

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.6 1.0 2.5 -0.3 1.0 -0.9 0.9 -1.0 1.6
Bipolar Disorder or Schizophrenia 0.2 0.5 1.0 0.7 -1.0 0.1 0.1 -1.0 0.6
Depressed Affect (Nagel 2018) 0.1 0.2 0.7 -0.0 -0.3 -0.5 -0.0 0.8 0.2
Depression (Nagel 2018) 0.3 0.5 1.1 0.5 -1.0 -1.1 0.5 0.5 -0.4
Intelligence (Savage-Jansen 2018) 0.2 0.7 3.1 -1.8 -0.2 -0.8 0.4 -0.1 0.3
Neuroticism (Nagel 2018) 0.2 0.5 1.7 -0.2 0.0 0.0 0.4 1.3 1.0
Schizophrenia (2018) 0.5 1.1 4.0 1.1 -2.0 0.8 -0.5 -0.5 -0.5
Schizophrenia vs Biploar Disorder 0.3 0.4 1.2 0.8 -1.1 0.0 -0.0 -0.7 0.4
Worry (Nagel 2018) 0.7 1.4 2.5 -0.2 1.5 1.3 1.1 0.9 1.6
Alzheimer’s Disease (in mother) 0.5 0.6 1.7 -0.0 -0.6 1.3 -1.2 0.3 -0.4
Alzheimer’s Disease (in father) 0.4 0.4 1.7 -0.4 0.1 0.7 -0.3 -0.4 -1.3
Alzheimer’s Disease (including proxy) 0.8 1.1 2.6 1.2 -0.6 1.6 -1.3 0.3 -0.8
Crohns Disease (2017) 0.3 0.6 1.2 -1.1 -0.4 -0.2 -0.7 -0.9 -1.0
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 -0.5 -0.1 0.3 0.1 -0.4 -0.7
Ulcerative Colitis (UC) 0.0 0.1 0.2 -0.2 0.4 0.0 0.4 0.2 -0.4
Major Depression (MDD) 0.5 0.7 1.1 -1.1 0.6 0.2 0.8 0.9 1.0
Reaction Time 1.0 1.8 4.2 -0.6 2.0 1.0 1.2 -0.2 2.0
Verbal and Numeric Reasoning (VNR) 0.5 1.3 4.3 -1.3 -0.1 -1.0 2.1 0.2 0.8
Breast Cancer 0.6 1.4 3.0 1.0 -0.1 -1.6 1.7 -0.2 1.3
Ovarian Cancer 0.7 0.9 3.6 0.4 -0.5 0.8 -0.5 0.7 -1.9
Prostate Cancer 0.1 0.1 0.2 -0.4 -0.3 -0.3 -0.2 0.2 0.4
Age at First Birth 1.2 1.7 3.7 1.6 1.2 -1.9 0.0 -1.4 0.6
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.2 0.3 -0.5 -0.2 0.0 0.0
Body Mass Index (BMI) (2010) 0.7 1.0 2.8 -0.5 -0.1 0.7 -1.7 0.0 -1.5
Coronary Artery Disease (CAD) 0.5 0.6 1.6 1.3 0.1 0.9 1.0 0.0 -0.6
Crohns Disease (2012) 0.4 0.7 2.0 -0.5 -0.5 -0.9 -0.1 -0.9 -1.4
Mean Putamen Volume 1.3 1.5 4.2 -1.6 1.4 0.2 0.4 0.5 -2.0
Fasting Glucose 0.3 0.3 0.9 -1.0 0.6 -0.7 0.4 -0.1 0.0
HbA1C 1.1 1.2 3.6 -1.0 0.7 -1.3 1.9 0.2 0.7
HDL Cholesterol 0.2 0.3 1.3 0.3 -1.2 -0.2 -0.3 -0.1 -0.2
LDL Cholesterol 0.4 0.6 1.4 1.2 0.0 0.5 0.9 -0.9 -0.1
Lupus 0.6 0.9 3.8 -0.3 0.0 -0.7 -0.0 -1.9 -0.9
Neuroticism (2016) 0.4 0.6 1.7 1.3 -0.5 -0.3 0.8 0.2 0.9
Primary Biliary Cirrhosis 0.5 0.8 2.3 -0.8 0.5 -0.6 0.2 -1.1 -1.5
Rheumatoid Arthritis 0.1 0.1 0.3 0.0 0.1 0.6 -0.4 -0.3 -0.0
Schizophrenia (2014) 0.4 0.8 1.9 0.9 -1.4 0.3 -0.1 -1.2 -0.5
Triglycerides 0.1 0.2 0.9 -0.2 0.2 0.1 0.0 -0.0 1.0
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.7 -0.5 -1.3 -1.0 -0.3 -0.3 0.4
Ulcerative Colitis 0.3 0.5 1.5 -0.1 -0.7 -0.3 0.6 0.7 -1.2
Blood Eosinophil Count 0.4 2.8 8.6 0.7 -2.9 0.3 -2.2 0.4 -1.6
Blood Platelet Count 0.5 5.5 20.2 4.5 -0.5 3.4 -0.2 1.1 0.1
Blood Red Count 0.0 0.3 0.7 0.8 -0.2 -0.3 -0.1 -0.4 0.8
Blood White Count 0.0 0.3 1.0 -1.0 -0.0 -0.1 0.1 0.8 0.5
Heel T-Score 0.2 1.3 3.4 1.8 0.7 1.3 -0.3 1.0 1.0
BMI 0.2 1.3 5.0 -0.5 -0.0 -0.5 -0.2 -1.5 -2.2
Height 0.3 6.3 14.2 3.1 3.8 -0.4 0.4 -2.5 2.7
Waist Hip Ratio (WHR) 0.6 2.8 5.1 2.1 -1.5 -1.2 -0.1 -2.3 -2.0
Systolic Blood Pressure 0.3 1.4 2.9 1.6 -1.7 -1.5 0.8 0.6 0.1
Smoking Status 1.2 2.8 5.1 -0.8 -1.7 -1.8 -2.2 -0.4 -2.3
Allergy or Eczema 0.5 1.2 6.1 2.5 0.8 -0.3 0.3 -0.6 0.2
Cardiovascular Disease 1.0 3.3 8.1 2.2 -1.4 -2.8 1.6 1.0 1.4
Hypothyroidism (self reported) 0.1 0.3 1.1 -0.6 0.2 1.0 -0.3 0.0 0.4
Respiratory disease 0.1 0.2 0.5 -0.7 0.3 -0.1 0.6 -0.2 -0.5
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.1 -1.0 0.9 0.3 0.9 1.1 1.0
Lung FEV1/FVC ratio 0.8 4.0 10.2 3.0 -0.0 3.2 -2.1 -0.8 -0.3
Lung FVC 0.3 1.4 3.6 -1.6 1.3 -1.9 -0.3 -0.3 0.5
Neuroticism 0.3 0.7 1.9 -0.2 0.9 0.9 0.7 1.4 0.2
Chronotype (morning person) 0.5 1.2 3.3 -0.8 1.8 -0.5 -0.0 -0.6 -1.6
Hair Pigment 0.0 0.6 1.4 0.9 -0.0 -1.2 0.2 -0.2 -1.0
Tanning 0.1 0.7 1.8 -1.2 -0.0 -0.7 -0.6 -1.3 -0.2
Hand grip strength (left) 0.8 2.2 3.8 1.7 2.0 -1.7 1.5 -0.9 -0.8
Number of treatments/medications taken 0.5 1.0 2.8 -0.3 0.5 0.2 1.5 1.7 -0.5
Average weekly spirits intake 0.9 1.1 4.3 0.8 0.1 0.4 0.5 -1.0 -2.1
Sensitivity / hurt feelings 0.4 0.6 1.6 -0.8 0.7 -0.8 0.1 -0.6 -1.3
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.9 -0.1 -0.1 0.5 0.4 0.9 -0.2
Hearing difficulty/problems: Yes 0.7 1.1 4.3 -0.5 -2.1 0.0 -1.1 0.5 -0.8
Relative age of first facial hair 1.1 2.3 7.2 -0.1 -2.7 -0.0 -0.9 2.1 1.2
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 1.7 0.8 -0.0 1.0 0.3 1.3 0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.5 -0.2 1.1 0.5 0.8 1.1 1.2
Ever had hysterectomy (womb removed) 0.5 0.6 2.4 1.6 -0.5 0.3 0.4 0.1 0.7
Systolic blood pressure, automated reading 0.2 0.6 1.3 0.1 -1.2 0.0 1.0 -0.1 -1.0
Eye problems/disorders: Diabetes related eye disease 2.2 2.4 10.1 -0.3 3.2 0.6 1.9 -0.7 0.5
Angina 1.0 1.3 3.9 2.0 -1.1 1.6 0.1 0.3 0.0
Medication for hormone replacement therapy 1.3 1.4 4.4 0.2 2.1 2.0 0.2 -0.2 -0.0
Vitamin and mineral supplements 1.0 1.3 5.5 -1.0 -0.9 -2.4 -0.4 -0.6 0.4
Supplements: Zinc 0.5 0.6 1.7 -0.3 0.2 -1.0 0.5 -1.3 -0.5
Medication: Co-codamol 1.2 1.4 4.7 -0.5 -0.5 1.2 -0.4 -1.2 -2.2
Medication: Metformin 1.6 2.3 4.9 -2.2 1.4 0.9 1.6 -0.1 -1.9
Diabetes (father) 0.8 1.0 1.8 -0.1 -1.3 -0.5 1.2 -0.5 -1.4
Diabetes (mother) 0.4 0.5 1.3 0.3 0.3 0.2 1.1 1.1 0.1
Severe depression (siblings) 0.5 0.6 1.4 1.0 0.6 0.6 1.2 -0.5 0.3
Pack years adult smoking proportion 0.4 0.6 1.3 -0.7 -0.8 -1.2 1.1 -0.3 0.0
Impedance of leg (right) 0.8 3.8 12.9 -0.3 -3.6 1.9 -2.2 1.2 0.4
Leg fat-free mass (left) 0.7 3.5 9.1 1.5 2.9 -1.1 0.7 -3.0 -0.1
Trunk fat percentage 1.0 3.8 13.7 -0.1 -3.7 1.2 -2.2 -0.3 -1.7
Hand grip strength (right) 1.0 2.6 5.9 0.9 1.7 -2.4 2.3 -0.7 -0.2
Townsend deprivation index at recruitment 0.1 0.2 0.8 -0.3 0.0 0.9 -0.4 -0.1 -0.0
Current tobacco smoking 0.8 1.4 2.3 -1.2 -1.1 -1.5 -0.9 -1.1 -1.1
Average weekly fortified wine intake 1.6 1.9 5.3 0.1 2.3 -0.5 -1.8 -0.5 -1.5
Maternal smoking around birth 0.8 1.1 3.8 -1.3 1.9 1.0 -0.2 -0.1 0.1
Fed-up feelings 0.3 0.5 1.3 0.7 -0.5 0.5 -0.3 1.1 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 2.5 0.9 -0.4 -1.6 0.5 -0.7 -0.2
Relative age voice broke 0.6 0.8 3.0 -0.5 -1.1 0.6 -1.7 0.3 0.0
Taking other prescription medications 0.8 1.2 3.0 -0.3 0.2 1.7 0.0 1.4 -1.4
Age when periods started (menarche) 0.5 1.2 3.1 1.4 0.4 -1.8 -1.5 0.3 -0.1
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 1.2 0.6 1.0 1.1 0.7 -0.1 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.1 0.4 -0.0 -1.0 -0.9 0.4 -0.3
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 1.9 0.3 0.5 0.9 -0.5 -0.7 -1.4
Qualifications: CSEs or equivalent 0.5 0.6 1.0 -1.0 -0.8 -0.4 0.9 -0.9 -0.0
Serious illness, injury or assault to yourself 0.9 1.1 1.4 1.2 1.2 1.1 -0.5 -1.2 -1.0
High blood pressure 0.2 0.6 1.9 1.1 -0.7 -1.4 0.4 0.2 0.3
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.8 1.7 1.0 -0.9 0.6 0.1 0.7
Multivitamins +/- minerals 0.4 0.5 2.4 0.1 0.2 1.6 -0.2 0.3 0.4
Stomach or abdominal pain in last month 0.9 1.1 2.1 -1.0 1.1 1.3 -0.9 -0.1 -1.4
Supplements: Glucosamine 0.3 0.3 1.3 0.1 -0.5 1.2 0.5 -0.0 -0.4
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.1 0.2 1.0 1.0 0.9 -1.2 -2.0
Medication: Atenolol 0.3 0.4 0.6 -0.5 -0.0 -0.8 0.7 0.7 -0.7
Medication: Levothyroxine sodium 0.5 0.8 1.8 0.7 0.5 1.4 -0.4 1.4 -0.5
Sitting height 0.4 2.9 6.2 1.5 2.5 -1.0 -0.2 -2.5 1.4
Chronic bronchitis/emphysema (father) 1.1 1.3 2.9 -0.8 -0.7 1.2 -1.6 0.3 -1.7
High blood pressure (mother) 1.4 2.0 8.3 0.8 -0.1 -0.0 2.9 0.3 1.7
Body mass index (BMI) 0.2 0.9 3.4 -0.2 -0.4 -0.4 -0.3 -1.2 -1.8
Impedance of leg (left) 0.9 4.3 11.8 -0.7 -3.4 1.7 -2.7 1.7 0.4
Leg predicted mass (left) 0.6 3.4 8.6 1.4 2.7 -1.2 0.7 -2.9 -0.1
Trunk fat mass 0.4 1.6 3.6 0.1 -1.9 0.5 -1.6 -1.1 -1.4
Waist circumference 0.6 2.1 5.3 0.3 -1.1 -0.8 -1.1 -2.0 -2.3
Number of incorrect matches in round 0.5 0.9 3.4 -0.9 -0.6 0.3 -0.6 0.6 -1.8
Past tobacco smoking 0.6 1.1 2.1 -0.5 1.4 -0.6 1.0 -1.0 1.4
Alcohol usually taken with meals 1.2 1.9 4.3 2.1 1.5 1.9 -0.0 0.9 -0.6
Nervous feelings 0.9 1.7 6.3 0.3 2.5 0.9 0.8 -0.4 1.5
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.9 0.9 0.2 -0.4 0.3 0.1 0.2
Hearing difficulty/problems with background noise 0.4 0.7 2.9 -0.1 -0.4 -0.1 0.5 -0.9 -1.7
Hair/balding pattern: Pattern 2 0.5 0.7 2.3 -0.5 -1.0 -1.5 -0.5 -0.4 0.3
Had menopause 0.5 0.6 2.0 -0.4 -0.9 1.4 0.1 0.2 -0.9
Had other major operations 1.0 1.3 2.9 -0.2 0.8 1.6 -1.2 0.0 -1.7
Forced vital capacity (FVC) 0.6 2.5 7.0 0.6 1.0 -2.6 -1.0 -2.2 0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.4 0.8 -0.9 -0.7 -0.6 1.2 0.7
Ever unenthusiastic/disinterested for a whole week 0.3 0.3 0.8 -0.9 0.7 -0.5 0.0 0.5 -0.3
Qualifications: None of the above 0.8 1.7 3.6 -0.1 0.0 1.7 -1.9 -1.5 1.2
Financial difficulties in last 2 years 0.2 0.3 0.8 -0.8 0.9 0.5 -0.2 -0.5 0.1
Mouth/teeth dental problems 0.3 0.4 2.3 -0.2 -0.1 -1.5 -0.5 -0.1 -0.3
Heart attack 0.6 0.8 1.5 0.7 0.7 1.2 -0.4 -1.0 -1.0
Allergy 0.3 0.6 1.5 -1.2 0.2 0.9 -1.0 0.2 -0.2
Pain all over the body in last month 1.3 1.4 3.9 1.6 0.7 0.1 2.0 0.3 1.2
Diabetes (self-reported) 0.5 0.7 3.2 -1.8 0.5 0.1 0.7 -0.5 0.2
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 3.1 1.8 1.3 0.6 0.9 0.5 0.0
Medication: Ramipril 0.5 0.7 2.2 -1.5 0.5 0.8 0.9 -0.3 0.0
Medication: Simvastatin 0.6 0.8 2.1 -0.3 0.2 1.4 0.1 1.5 0.8
Fluid intelligence score 0.8 1.7 3.7 -1.9 1.3 -0.7 1.7 0.9 0.7
Illnesses of siblings 1.0 1.5 4.1 -0.2 2.0 -0.2 -1.8 -1.0 -0.5
Neuroticism score 0.1 0.2 0.6 -0.6 0.1 0.2 0.5 0.8 -0.4
Weight 0.2 0.9 3.4 0.7 0.5 -0.8 -0.7 -1.8 -0.7
Impedance of arm (right) 1.5 7.0 26.0 0.3 -5.1 2.5 -2.3 1.9 0.6
Arm fat percentage (right) 0.7 2.7 7.8 -0.2 -2.8 0.9 -1.5 -1.0 -2.1
Trunk fat-free mass 1.2 7.1 23.8 1.3 4.9 -1.6 1.3 -3.4 0.7
Hip circumference 0.3 1.1 3.2 -0.5 0.0 0.3 -1.4 -1.8 -1.2
Time employed in main current job 1.4 1.7 3.3 1.3 1.8 0.9 -0.3 -1.7 1.1
Alcohol intake versus 10 years previously 0.2 0.3 1.4 0.3 -0.4 -0.4 0.3 -1.2 -0.3
Father’s age at death 1.0 1.3 3.0 1.7 0.9 1.2 -0.5 1.5 -0.4
Worrier / anxious feelings 0.2 0.4 1.5 -1.2 0.9 0.5 0.1 0.3 -0.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 1.1 -0.1 0.0 0.5 0.2 -0.3 -1.1
Falls in the last year 0.6 0.7 3.0 0.7 1.7 0.5 -0.2 0.8 0.4
Hair/balding pattern: Pattern 3 0.7 1.1 2.3 1.5 -1.3 1.1 1.2 0.0 0.1
Number of live births 0.8 1.2 2.5 -0.1 -0.2 1.4 0.1 -1.5 -1.6
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.9 1.7 0.9 -1.3 -1.0 -2.0 0.8
Pulse rate 1.7 2.9 6.1 1.6 -1.3 2.1 -1.4 -2.5 -0.7
Happiness 0.3 0.3 0.8 0.1 -0.1 0.9 -0.7 -0.1 0.9
Noisy workplace 1.3 1.6 4.1 1.7 -0.8 -0.4 -1.1 -2.0 -1.1
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.7 -0.7 0.4 1.2 0.2 0.1 -1.3
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.7 -0.4 -0.8 -0.0 -0.1 -0.1 -0.7
Mouth/teeth dental problems: Dentures 0.7 1.1 3.9 -0.5 0.9 2.0 0.6 -1.0 0.8
Asthma 0.4 0.8 2.8 -1.7 0.1 -0.3 1.1 0.7 -0.6
Medication: Ibuprofen (e.g. Nurofen) 0.1 0.1 0.3 0.4 -0.5 0.6 0.1 0.3 -0.0
Medication: Cholesterol lowering 1.2 1.9 5.1 -0.2 0.2 -0.4 1.6 2.3 1.8
Depression (self-reported) 0.9 1.1 3.2 -0.5 1.6 0.0 1.8 0.7 0.5
Medication: Lansoprazole 0.4 0.5 1.5 -0.7 0.5 -0.1 -0.6 0.6 -1.2
Prospective memory result 1.0 1.3 3.8 0.4 0.2 1.4 -1.0 -2.0 -0.8
Lung cancer (father) 0.8 1.0 3.2 -1.8 1.3 -0.5 -0.2 -0.6 0.4
Illnesses of mother 0.5 0.6 2.6 -0.2 0.7 -0.4 -1.6 -0.2 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 5.3 2.3 0.5 -2.0 -1.0 -2.2 1.1
Pulse wave Arterial Stiffness index 2.8 3.3 8.1 2.9 -1.2 -1.9 -1.6 -1.3 1.5
Impedance of arm (left) 1.4 6.7 26.3 0.3 -5.1 1.9 -2.8 1.5 0.4
Arm fat mass (right) 0.4 1.5 3.2 0.4 -1.2 0.0 -1.0 -1.8 -1.8
Trunk predicted mass 1.2 7.0 22.8 1.3 4.8 -1.7 1.3 -3.5 0.8
Standing height 0.3 3.3 6.5 2.2 2.1 -1.0 -0.5 -1.7 2.6
Length of working week for main job 0.3 0.4 1.4 0.4 0.0 -0.3 -0.7 -1.2 -0.3
Exposure to tobacco smoke at home 1.0 1.1 4.1 0.5 2.0 -0.1 -1.2 -0.6 0.5
Breastfed as a baby 0.6 0.8 2.7 -0.5 -0.5 0.8 -0.6 1.6 0.5
Tense / ‘highly strung’ 0.4 0.6 1.4 -0.6 1.2 0.6 -0.6 0.9 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.8 -0.8 0.2 -0.4 0.8 -0.1 -0.9
Hair/balding pattern: Pattern 4 0.3 0.8 3.3 -0.0 1.8 0.6 0.7 -0.7 0.4
Birth weight of first child 0.4 0.7 1.8 -0.2 1.0 0.2 1.0 -0.6 -1.4
Peak expiratory flow (PEF) 0.3 0.8 3.7 1.9 0.2 0.1 -1.0 0.3 -0.2
Pulse wave reflection index 1.2 1.5 6.4 1.1 -0.5 -2.5 -0.6 0.0 1.0
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.1 0.3 1.0 1.0 -0.3 0.3 0.9
Loud music exposure frequency 1.2 1.4 3.6 -0.7 -1.9 0.7 -1.6 0.4 0.9
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 4.7 -2.2 -0.1 -1.6 1.1 0.5 -1.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.0 -0.1 -0.7 0.3 0.2 -1.0 -0.8
Blood clot in the leg (DVT) 1.0 1.3 2.8 1.7 -1.2 0.7 1.5 0.6 0.5
Medication: Paracetamol 0.2 0.3 1.4 0.1 -1.2 0.4 -0.5 0.1 0.1
Headache pain in last month 0.9 1.6 2.8 -0.7 -1.1 0.0 -1.7 1.4 -1.7
Medication for cholesterol, blood pressure or diabetes 1.6 2.6 6.1 0.4 0.2 2.0 -2.5 -1.7 -1.6
Glaucoma (self-reported) 1.2 1.4 4.6 -0.1 0.6 -2.1 0.6 -1.7 -0.3
Gout (self-reported) 0.7 0.9 2.9 1.7 -0.3 0.5 -1.0 -0.0 -1.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 2.2 -0.7 0.8 1.5 -0.8 0.8 -0.4
Medication: Amlodipine 0.7 1.0 5.0 2.2 -0.6 -0.4 0.7 -0.1 0.4
Medication: Ventolin 100micrograms inhaler 0.4 0.6 1.2 0.5 -0.1 0.3 1.1 -0.8 -1.1
Birth weight 0.3 0.7 2.0 -1.0 0.3 0.0 -0.9 -1.4 -0.7
Chronic bronchitis/emphysema (mother) 0.6 0.7 2.7 0.3 0.8 0.7 1.6 0.7 0.5
High blood pressure (siblings) 1.0 1.5 3.7 0.2 -1.6 -0.6 1.9 1.5 -0.2
Forced vital capacity (FVC), Best measure 0.8 3.0 9.7 0.9 0.8 -3.1 -0.6 -2.2 1.2
Body fat percentage 0.9 3.7 11.8 -0.1 -3.4 1.1 -2.2 -0.7 -2.0
Leg fat percentage (right) 0.6 2.0 5.0 -0.4 -2.2 0.9 -1.4 -0.8 -1.9
Arm fat-free mass (right) 0.9 4.6 14.2 1.0 3.8 -1.6 0.6 -3.0 0.1
Exposure to tobacco smoke outside home 2.1 2.8 7.2 -2.1 0.7 -1.8 2.7 -0.2 0.9
Comparative body size at age 10 0.7 1.8 5.6 2.4 1.7 -0.1 1.2 -0.8 -0.6
Number of full brothers 0.1 0.1 0.1 -0.4 0.3 0.1 0.2 -0.3 0.3
Worry too long after embarrassment 0.4 0.7 1.5 0.2 -1.0 -0.5 1.2 1.0 -0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 4.0 -2.0 0.4 0.1 1.2 -0.5 0.1
Wheeze or whistling in the chest in last year 0.4 0.7 3.4 -0.8 -1.9 0.1 0.5 0.1 -0.1
Number of children fathered 0.5 0.5 1.7 0.6 1.3 0.2 -0.3 -0.1 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.2 0.7 0.6 0.1 0.9 1.1 2.0
Age at first live birth 0.4 0.7 2.3 -0.5 0.5 -1.3 1.5 0.1 0.2
Pulse wave peak to peak time 2.5 3.0 6.8 -2.6 1.6 1.7 1.7 1.3 -1.1
Health satisfaction 1.8 2.3 4.2 -1.2 -2.0 1.6 -1.8 -1.3 -0.9
Shortness of breath walking on level ground 0.5 0.6 1.3 -0.9 -0.4 1.1 -0.7 0.2 -0.7
Qualifications: College or University degree 0.2 0.7 2.2 1.5 0.1 0.7 -0.3 1.0 -0.7
Eye problems/disorders: None of the above 1.7 1.9 4.9 -0.6 -2.2 1.0 -1.0 1.1 1.7
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.0 -1.7 -1.2 0.8 0.1 1.5 -0.5
Emphysema/chronic bronchitis 1.3 1.4 3.8 -1.5 -0.6 0.2 1.0 -1.9 1.0
Medication for pain relief, constipation, heartburn 0.9 1.5 3.5 -0.4 1.7 -1.3 -0.7 -1.9 0.5
Neck or shoulder pain in last month 1.9 2.7 4.6 0.5 -1.8 2.1 -2.1 -1.0 -1.7
Medication: Blood pressure 0.8 1.3 5.1 0.1 -0.3 -0.9 2.3 1.4 0.1
Angina (self-reported) 0.9 1.2 3.7 1.9 -0.9 1.5 0.1 0.6 0.3
Migraine (self-reported) 1.4 1.7 4.1 -1.1 0.1 -1.9 -1.1 0.0 -2.0
Medication: Ibuprofen 0.3 0.3 1.0 0.3 0.4 0.8 0.2 1.0 0.1
Medication: Allopurinol 1.1 1.4 5.8 2.4 -0.2 -0.2 0.1 -0.6 -1.5
Medication: Omeprazole 0.9 1.0 1.7 0.1 -1.2 1.3 1.1 1.1 -0.9
Medication: Seretide 50 evohaler 0.3 0.3 0.9 0.9 -0.3 0.4 -0.8 0.1 -0.5
Mean time to correctly identify matches 0.8 1.4 2.5 -1.0 1.1 1.6 1.3 0.2 1.5
Heart disease (mother) 1.6 1.9 4.8 0.2 -2.2 -1.3 -1.8 0.5 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 3.5 1.9 -0.8 1.1 1.2 1.2 -0.9
Whole body fat mass 0.3 1.5 2.6 0.4 -1.4 0.4 -1.4 -1.6 -1.5
Leg fat mass (right) 0.4 1.5 3.7 0.4 -0.8 -0.1 -1.2 -1.9 -1.8
Arm predicted mass (right) 1.0 5.0 15.4 0.9 3.9 -1.9 0.7 -3.1 0.2
Pulse rate, automated reading 0.3 1.0 3.5 -0.5 -1.2 0.8 -0.3 -1.9 -0.1
Alcohol intake frequency. 0.1 0.3 0.8 -0.9 0.6 0.3 0.7 0.4 -0.2
Comparative height size at age 10 0.3 1.7 5.1 1.2 1.1 -0.3 -0.4 -2.2 1.4
Number of full sisters 0.9 1.1 3.5 -0.1 -0.8 1.2 1.9 0.8 0.6
Suffer from ‘nerves’ 0.7 1.1 3.1 1.3 0.7 0.7 1.8 -0.2 1.0
Overall health rating 1.2 2.7 6.8 -1.3 -2.5 0.6 -2.6 -0.9 -0.2
Chest pain or discomfort 0.6 0.8 1.7 0.6 -0.6 -0.8 -1.2 -0.6 -1.3
Had major operations 2.2 2.6 6.7 1.7 2.6 -0.5 2.0 -1.2 0.8
Age at last live birth 0.7 1.1 2.1 -0.5 1.0 -1.4 1.0 -1.0 -1.0
Family relationship satisfaction 0.3 0.3 0.9 -0.5 0.2 -1.0 0.4 -0.8 0.3
Leg pain on walking 0.7 0.9 2.4 1.5 -0.2 1.6 -0.6 0.2 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.4 -0.3 -1.0 -1.2 0.2 -0.2 -0.7
Commuting to job workplace: Car/motor vehicle 1.0 1.1 3.5 -1.9 -0.2 0.5 -1.3 -0.0 -1.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.4 -0.4 -0.1 -0.8 0.5 1.6 0.9
Medication: Aspirin 0.9 1.2 5.6 -0.8 -0.7 -0.2 0.6 2.4 0.3
Supplements: Vitamin C 0.7 0.8 2.0 1.4 0.0 1.4 0.7 0.5 0.2
Knee pain experienced in last month 0.8 1.3 7.3 0.4 -0.2 2.7 -0.3 -0.5 0.1
Hypertension (Self-reported) 0.3 0.8 2.3 1.1 -0.5 -1.5 0.7 0.6 0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.7 0.8 1.9 0.4 -0.6 1.4 -1.1 -0.6 -1.0
Illnesses of father: Heart disease 0.6 0.8 2.4 0.8 0.2 0.2 -1.1 0.5 -1.5
Illnesses of siblings: Diabetes 1.6 1.9 6.2 0.9 -1.2 1.2 2.5 0.5 1.2
Smoking status: Previous 0.8 1.2 2.6 0.8 -1.2 1.4 -0.4 1.6 -0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.9 5.4 2.3 1.5 -0.3 0.2 -1.8 -0.5
Whole body fat-free mass 1.0 5.6 17.3 1.3 4.2 -1.5 1.0 -3.3 0.2
Leg fat-free mass (right) 0.6 3.4 8.9 1.3 3.0 -1.4 0.7 -2.7 0.1
Arm fat percentage (left) 0.7 2.8 7.6 -0.3 -2.8 0.5 -1.6 -1.2 -2.3
Average weekly red wine intake 0.6 0.8 2.1 0.8 1.4 1.3 -0.1 -0.8 -0.2
Handedness (chirality/laterality): Left-handed 1.5 1.9 5.6 0.2 -0.3 0.3 -0.4 2.4 -2.3
Mood swings 0.1 0.2 0.7 -0.1 -0.6 -0.8 -0.3 -0.1 -0.4
Loneliness, isolation 0.4 0.6 1.0 -0.7 -0.4 1.0 0.6 -0.9 -0.9
Long-standing illness, disability or infirmity 0.2 0.3 0.9 0.3 0.6 0.9 0.5 0.2 0.2
Ever had bowel cancer screening 0.3 0.4 1.2 0.4 -0.5 0.6 -0.2 1.1 0.4
Diabetes diagnosed by doctor 0.4 0.6 2.6 -1.6 0.7 0.4 0.5 0.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 6.0 -2.4 -0.1 1.1 0.3 0.0 -0.1
Friendships satisfaction 0.7 0.9 2.1 -0.8 -0.0 -0.9 -0.6 1.2 1.5
Qualifications: nursing, teaching 0.9 1.3 4.9 0.8 0.6 1.1 0.5 2.2 -0.7
Commuting to job workplace: Walk 0.1 0.1 0.3 -0.0 -0.4 -0.3 0.3 0.5 0.6
Eye problems/disorders: Cataract 0.3 0.4 1.1 -0.2 0.1 -1.0 0.1 0.4 -1.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.7 2.2 0.1 -0.7 0.1 0.4 1.1
Medication for cholesterol 0.4 0.6 1.7 -1.3 0.0 -0.9 0.1 0.6 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.4 1.6 5.9 1.1 -0.5 2.4 -1.0 -1.1 -0.2
Back pain experienced in last month 0.8 1.1 2.5 -1.6 -0.2 1.2 -1.3 -1.0 -0.0
Mineral and other dietary supplements 0.4 0.5 1.9 -0.1 -0.6 -1.4 0.2 0.2 0.8
Breast cancer (self-reported) 1.2 1.4 4.2 -0.3 0.5 0.4 -2.1 -1.2 -1.4
Asthma (self-reported) 0.4 0.8 2.2 -1.5 0.1 -0.7 1.1 0.4 -0.7
Osteoporosis (self-reported) 0.7 0.9 1.9 0.3 -1.4 0.9 -1.2 0.8 0.5
Osteoarthritis (self-reported) 0.4 0.5 1.6 0.1 1.3 0.8 -0.1 -0.4 -0.8
Medication: Aspirin 0.6 0.8 3.6 0.2 -0.7 0.1 0.7 1.9 0.5
Medication: Gliclazide 0.5 0.6 1.6 -0.8 1.0 -0.1 1.3 -0.5 0.1
Illnesses of father: None of the above (group 1) 1.4 1.7 6.6 -0.3 1.1 -0.7 1.3 -0.6 2.6
Smoking status: Current 0.9 1.5 2.3 -1.1 -0.8 -1.5 -1.0 -1.2 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 3.5 -0.0 0.8 -1.3 -1.0 -1.9 1.2
Whole body water mass 1.0 5.5 17.1 1.4 4.1 -1.5 1.1 -3.3 0.2
Leg predicted mass (right) 0.7 3.5 9.3 1.4 3.0 -1.4 0.7 -2.8 -0.0
Arm fat mass (left) 0.3 1.4 3.6 0.2 -1.0 -0.2 -1.0 -1.9 -1.7
Number of self-reported non-cancer illnesses 0.3 0.6 2.0 0.5 -0.2 0.5 0.8 1.4 0.3
Average weekly champagne plus white wine intake 0.2 0.3 1.1 0.6 0.3 0.1 0.4 1.1 0.1
Miserableness 0.1 0.2 0.5 -0.2 0.1 0.6 0.3 0.5 -0.7
Guilty feelings 0.8 1.2 3.9 -0.9 2.0 0.2 1.0 1.2 -0.5
Wears glasses or contact lenses 0.4 0.4 1.3 0.2 1.1 -0.1 -0.5 0.7 0.7
Ever taken oral contraceptive pill 0.7 0.8 1.8 -1.3 -0.4 -0.4 -1.0 -1.3 -0.3
Hearing aid user 0.9 1.0 3.4 0.0 1.8 -0.1 0.9 0.7 1.2
Mother’s age at death 0.2 0.3 1.5 1.2 -0.1 -0.2 0.4 -0.2 -0.1
Financial situation satisfaction 0.8 1.0 4.5 0.4 0.1 2.1 -1.1 0.5 0.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 1.1 0.3 -0.8 -1.0 -0.2 0.0 0.4
Commuting to job workplace: Public transport 0.2 0.3 1.0 0.5 0.1 -1.0 0.5 0.2 0.2
Eye problems/disorders: Glaucoma 0.9 1.0 3.0 0.6 1.4 -1.7 0.8 -0.6 0.4
Medication: Blood pressure 0.6 1.1 2.6 0.5 -1.2 -0.7 -1.2 -0.6 -1.6
Pain type(s) experienced in last month: Hip pain 1.0 1.2 5.1 0.4 1.4 2.3 -0.1 -0.3 0.3
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.6 0.3 -0.1 1.6 -0.8 -0.6 -1.1
High cholesterol (Self-reported) 0.8 1.4 3.8 -0.3 -0.1 -0.2 1.1 1.7 2.0
Medication: Bendroflumethiazide 0.5 0.7 2.4 -0.5 -0.1 -1.5 -0.0 0.9 0.9
Medication: Paracetamol 0.3 0.4 2.3 -0.0 -1.5 0.2 0.1 0.3 0.1
Medication: Lisinopril 0.7 0.9 1.7 0.0 -0.6 -1.3 1.1 0.9 -1.2
Medication: Atorvastatin 1.8 2.2 6.1 1.5 0.7 2.5 1.5 0.3 -1.4
Illnesses of father: High blood pressure 1.4 1.7 3.6 -1.7 -1.9 -0.1 -1.2 1.0 -1.2
Alcohol drinker status: Never 0.6 0.7 2.1 1.0 1.4 -1.0 0.4 0.3 -0.4
Ever smoked 0.8 1.5 3.8 0.4 -2.0 -0.1 -0.9 0.8 -1.8
Basal metabolic rate 0.8 4.2 11.2 1.3 3.3 -1.5 0.6 -3.2 0.1
Leg fat percentage (left) 0.6 2.0 3.9 -0.7 -2.0 0.7 -1.8 -0.6 -1.9
Arm fat-free mass (left) 0.9 4.5 13.2 1.0 3.6 -1.6 0.5 -3.1 -0.3
Number of operations (self-reported) 1.2 1.8 6.8 0.1 2.6 0.7 1.4 0.8 -0.8
Average weekly beer plus cider intake 1.5 2.2 4.3 -1.8 0.9 -2.1 0.3 1.5 1.6
Irritability 0.2 0.4 0.6 -0.8 -0.7 -0.2 -0.2 0.8 -0.7
Risk taking 1.2 1.8 3.0 1.3 -0.8 1.6 -1.7 -1.7 -0.4
Ever had prostate specific antigen (PSA) test 0.9 1.1 2.6 0.5 0.1 -0.6 1.0 1.4 1.6
Fractured/broken bones in last 5 years 0.6 0.8 2.1 0.5 1.4 1.4 -0.2 0.6 0.1
Age started oral contraceptive pill 0.1 0.2 0.8 0.9 -0.2 0.6 -0.1 -0.1 -0.0
Diastolic blood pressure, automated reading 0.2 0.8 2.2 -0.0 -1.3 0.4 0.2 -0.5 -1.5
Ever depressed for a whole week 0.6 0.7 3.0 -1.7 0.5 -1.0 0.1 0.1 0.1
Unable to work because of sickness or disability 0.3 0.4 1.3 0.2 1.0 1.1 0.1 -0.0 0.6
Commuting to job workplace: Cycle 1.6 1.9 5.2 1.2 1.7 2.3 0.3 0.3 1.4
Myopia 1.0 1.4 2.9 0.8 -0.7 1.0 -1.0 1.6 1.7
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.3 -1.0 1.1 1.1 0.0 0.2 0.3
Cholesterol lowering medication 0.8 1.2 4.6 1.2 0.5 2.1 0.2 -0.7 -0.5
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.2 0.3 -0.3 1.6 1.0 0.8 -1.8
Pain experienced in last month 0.5 0.9 4.2 -0.2 -0.1 -2.0 1.0 0.3 -0.0
Supplements: Calcium 0.5 0.6 1.9 0.5 -0.6 -0.4 0.7 0.5 1.4
Basal cell carcinoma (self-reported) 1.3 1.6 6.5 2.6 -1.5 -0.6 -0.2 0.2 -0.5
Heart attack/myocardial infarction (self-reported) 0.7 0.9 1.5 0.7 0.5 1.2 -0.6 -1.2 -1.2
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 3.0 1.4 -1.3 0.4 1.7 0.6 0.2
Heart disease (siblings) 0.3 0.4 1.0 -0.1 -1.0 0.5 0.1 -0.3 -0.9
Alcohol drinker status: Previous 0.6 0.7 2.1 -0.7 0.5 0.7 -0.7 1.5 0.7
Pack years of smoking 0.3 0.5 1.0 -0.7 -1.0 -0.8 0.9 -0.3 -0.1
Impedance of whole body 1.3 6.7 24.0 0.1 -4.9 1.9 -2.8 2.1 0.5
Leg fat mass (left) 0.3 1.3 2.9 0.2 -0.5 -0.2 -1.3 -1.7 -1.7
Arm predicted mass (left) 0.9 4.4 13.8 1.2 3.7 -1.5 0.5 -3.0 -0.1