TWAS hub - RIN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0920	0.0340	0.00490	0.012	0.011	0.004	0.011	0.013	0.013	0.01500	0.0970	0.0150	0.0078
2	GTEx	Artery Aorta	0.1440	0.0540	0.00650	0.010	NA	0.010	NA	0.008	0.090	NA	0.0850	NA	0.1100
3	GTEx	Esophagus Mucosa	0.1170	0.0450	0.00820	0.000	NA	0.009	NA	0.004	0.310	NA	0.0780	NA	0.1700
4	YFS	Blood	0.0473	0.0148	0.00013	-0.001	0.005	0.007	0.005	0.000	0.760	0.00780	0.0023	0.0084	0.5100
5	TCGA	Breast Invasive Carcinoma	0.0382	0.0150	0.00190	-0.001	0.018	0.006	NA	0.000	0.650	0.00012	0.0190	NA	0.2500
6	TCGA	Prostate Adenocarcinoma	0.0530	0.0233	0.00900	0.003	0.020	-0.002	NA	0.000	0.150	0.00280	0.6500	NA	0.3300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Pulse wave Arterial Stiffness index	2.8	3.3	8.1	2.9	-1.2	-1.9	-1.6	-1.3	1.5
Pulse wave peak to peak time	2.5	3.0	6.8	-2.6	1.6	1.7	1.7	1.3	-1.1
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	10.1	-0.3	3.2	0.6	1.9	-0.7	0.5
Had major operations	2.2	2.6	6.7	1.7	2.6	-0.5	2.0	-1.2	0.8
Exposure to tobacco smoke outside home	2.1	2.8	7.2	-2.1	0.7	-1.8	2.7	-0.2	0.9
Neck or shoulder pain in last month	1.9	2.7	4.6	0.5	-1.8	2.1	-2.1	-1.0	-1.7
Health satisfaction	1.8	2.3	4.2	-1.2	-2.0	1.6	-1.8	-1.3	-0.9
Medication: Atorvastatin	1.8	2.2	6.1	1.5	0.7	2.5	1.5	0.3	-1.4
Pulse rate	1.7	2.9	6.1	1.6	-1.3	2.1	-1.4	-2.5	-0.7
Eye problems/disorders: None of the above	1.7	1.9	4.9	-0.6	-2.2	1.0	-1.0	1.1	1.7
Medication: Metformin	1.6	2.3	4.9	-2.2	1.4	0.9	1.6	-0.1	-1.9
Average weekly fortified wine intake	1.6	1.9	5.3	0.1	2.3	-0.5	-1.8	-0.5	-1.5
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	6.1	0.4	0.2	2.0	-2.5	-1.7	-1.6
Heart disease (mother)	1.6	1.9	4.8	0.2	-2.2	-1.3	-1.8	0.5	-1.1
Illnesses of siblings: Diabetes	1.6	1.9	6.2	0.9	-1.2	1.2	2.5	0.5	1.2
Commuting to job workplace: Cycle	1.6	1.9	5.2	1.2	1.7	2.3	0.3	0.3	1.4
Impedance of arm (right)	1.5	7.0	26.0	0.3	-5.1	2.5	-2.3	1.9	0.6
Handedness (chirality/laterality): Left-handed	1.5	1.9	5.6	0.2	-0.3	0.3	-0.4	2.4	-2.3
Average weekly beer plus cider intake	1.5	2.2	4.3	-1.8	0.9	-2.1	0.3	1.5	1.6
High blood pressure (mother)	1.4	2.0	8.3	0.8	-0.1	-0.0	2.9	0.3	1.7
Time employed in main current job	1.4	1.7	3.3	1.3	1.8	0.9	-0.3	-1.7	1.1
Impedance of arm (left)	1.4	6.7	26.3	0.3	-5.1	1.9	-2.8	1.5	0.4
Migraine (self-reported)	1.4	1.7	4.1	-1.1	0.1	-1.9	-1.1	0.0	-2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	5.9	1.1	-0.5	2.4	-1.0	-1.1	-0.2
Illnesses of father: None of the above (group 1)	1.4	1.7	6.6	-0.3	1.1	-0.7	1.3	-0.6	2.6
Illnesses of father: High blood pressure	1.4	1.7	3.6	-1.7	-1.9	-0.1	-1.2	1.0	-1.2
Mean Putamen Volume	1.3	1.5	4.2	-1.6	1.4	0.2	0.4	0.5	-2.0
Medication for hormone replacement therapy	1.3	1.4	4.4	0.2	2.1	2.0	0.2	-0.2	-0.0
Pain all over the body in last month	1.3	1.4	3.9	1.6	0.7	0.1	2.0	0.3	1.2
Noisy workplace	1.3	1.6	4.1	1.7	-0.8	-0.4	-1.1	-2.0	-1.1
Emphysema/chronic bronchitis	1.3	1.4	3.8	-1.5	-0.6	0.2	1.0	-1.9	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.5	1.9	-0.8	1.1	1.2	1.2	-0.9
Basal cell carcinoma (self-reported)	1.3	1.6	6.5	2.6	-1.5	-0.6	-0.2	0.2	-0.5
Impedance of whole body	1.3	6.7	24.0	0.1	-4.9	1.9	-2.8	2.1	0.5
Age at First Birth	1.2	1.7	3.7	1.6	1.2	-1.9	0.0	-1.4	0.6
Smoking Status	1.2	2.8	5.1	-0.8	-1.7	-1.8	-2.2	-0.4	-2.3
Medication: Co-codamol	1.2	1.4	4.7	-0.5	-0.5	1.2	-0.4	-1.2	-2.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.1	0.2	1.0	1.0	0.9	-1.2	-2.0
Alcohol usually taken with meals	1.2	1.9	4.3	2.1	1.5	1.9	-0.0	0.9	-0.6
Trunk fat-free mass	1.2	7.1	23.8	1.3	4.9	-1.6	1.3	-3.4	0.7
Medication: Cholesterol lowering	1.2	1.9	5.1	-0.2	0.2	-0.4	1.6	2.3	1.8
Trunk predicted mass	1.2	7.0	22.8	1.3	4.8	-1.7	1.3	-3.5	0.8
Pulse wave reflection index	1.2	1.5	6.4	1.1	-0.5	-2.5	-0.6	0.0	1.0
Loud music exposure frequency	1.2	1.4	3.6	-0.7	-1.9	0.7	-1.6	0.4	0.9
Glaucoma (self-reported)	1.2	1.4	4.6	-0.1	0.6	-2.1	0.6	-1.7	-0.3
Overall health rating	1.2	2.7	6.8	-1.3	-2.5	0.6	-2.6	-0.9	-0.2
Breast cancer (self-reported)	1.2	1.4	4.2	-0.3	0.5	0.4	-2.1	-1.2	-1.4
Number of operations (self-reported)	1.2	1.8	6.8	0.1	2.6	0.7	1.4	0.8	-0.8
Risk taking	1.2	1.8	3.0	1.3	-0.8	1.6	-1.7	-1.7	-0.4
HbA1C	1.1	1.2	3.6	-1.0	0.7	-1.3	1.9	0.2	0.7
Relative age of first facial hair	1.1	2.3	7.2	-0.1	-2.7	-0.0	-0.9	2.1	1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	2.9	-0.8	-0.7	1.2	-1.6	0.3	-1.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.0	-1.7	-1.2	0.8	0.1	1.5	-0.5
Medication: Allopurinol	1.1	1.4	5.8	2.4	-0.2	-0.2	0.1	-0.6	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	6.0	-2.4	-0.1	1.1	0.3	0.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.2	0.3	-0.3	1.6	1.0	0.8	-1.8
Reaction Time	1.0	1.8	4.2	-0.6	2.0	1.0	1.2	-0.2	2.0
Cardiovascular Disease	1.0	3.3	8.1	2.2	-1.4	-2.8	1.6	1.0	1.4
Angina	1.0	1.3	3.9	2.0	-1.1	1.6	0.1	0.3	0.0
Vitamin and mineral supplements	1.0	1.3	5.5	-1.0	-0.9	-2.4	-0.4	-0.6	0.4
Trunk fat percentage	1.0	3.8	13.7	-0.1	-3.7	1.2	-2.2	-0.3	-1.7
Hand grip strength (right)	1.0	2.6	5.9	0.9	1.7	-2.4	2.3	-0.7	-0.2
Had other major operations	1.0	1.3	2.9	-0.2	0.8	1.6	-1.2	0.0	-1.7
Illnesses of siblings	1.0	1.5	4.1	-0.2	2.0	-0.2	-1.8	-1.0	-0.5
Father’s age at death	1.0	1.3	3.0	1.7	0.9	1.2	-0.5	1.5	-0.4
Prospective memory result	1.0	1.3	3.8	0.4	0.2	1.4	-1.0	-2.0	-0.8
Exposure to tobacco smoke at home	1.0	1.1	4.1	0.5	2.0	-0.1	-1.2	-0.6	0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.7	-2.2	-0.1	-1.6	1.1	0.5	-1.0
Blood clot in the leg (DVT)	1.0	1.3	2.8	1.7	-1.2	0.7	1.5	0.6	0.5
High blood pressure (siblings)	1.0	1.5	3.7	0.2	-1.6	-0.6	1.9	1.5	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.2	0.7	0.6	0.1	0.9	1.1	2.0
Arm predicted mass (right)	1.0	5.0	15.4	0.9	3.9	-1.9	0.7	-3.1	0.2
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.5	-1.9	-0.2	0.5	-1.3	-0.0	-1.1
Whole body fat-free mass	1.0	5.6	17.3	1.3	4.2	-1.5	1.0	-3.3	0.2
Whole body water mass	1.0	5.5	17.1	1.4	4.1	-1.5	1.1	-3.3	0.2
Pain type(s) experienced in last month: Hip pain	1.0	1.2	5.1	0.4	1.4	2.3	-0.1	-0.3	0.3
Myopia	1.0	1.4	2.9	0.8	-0.7	1.0	-1.0	1.6	1.7
Average weekly spirits intake	0.9	1.1	4.3	0.8	0.1	0.4	0.5	-1.0	-2.1
Serious illness, injury or assault to yourself	0.9	1.1	1.4	1.2	1.2	1.1	-0.5	-1.2	-1.0
Stomach or abdominal pain in last month	0.9	1.1	2.1	-1.0	1.1	1.3	-0.9	-0.1	-1.4
Impedance of leg (left)	0.9	4.3	11.8	-0.7	-3.4	1.7	-2.7	1.7	0.4
Nervous feelings	0.9	1.7	6.3	0.3	2.5	0.9	0.8	-0.4	1.5
Depression (self-reported)	0.9	1.1	3.2	-0.5	1.6	0.0	1.8	0.7	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.3	2.3	0.5	-2.0	-1.0	-2.2	1.1
Headache pain in last month	0.9	1.6	2.8	-0.7	-1.1	0.0	-1.7	1.4	-1.7
Body fat percentage	0.9	3.7	11.8	-0.1	-3.4	1.1	-2.2	-0.7	-2.0
Arm fat-free mass (right)	0.9	4.6	14.2	1.0	3.8	-1.6	0.6	-3.0	0.1
Medication for pain relief, constipation, heartburn	0.9	1.5	3.5	-0.4	1.7	-1.3	-0.7	-1.9	0.5
Angina (self-reported)	0.9	1.2	3.7	1.9	-0.9	1.5	0.1	0.6	0.3
Medication: Omeprazole	0.9	1.0	1.7	0.1	-1.2	1.3	1.1	1.1	-0.9
Number of full sisters	0.9	1.1	3.5	-0.1	-0.8	1.2	1.9	0.8	0.6
Medication: Aspirin	0.9	1.2	5.6	-0.8	-0.7	-0.2	0.6	2.4	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.4	2.3	1.5	-0.3	0.2	-1.8	-0.5
Qualifications: nursing, teaching	0.9	1.3	4.9	0.8	0.6	1.1	0.5	2.2	-0.7
Smoking status: Current	0.9	1.5	2.3	-1.1	-0.8	-1.5	-1.0	-1.2	-1.4
Hearing aid user	0.9	1.0	3.4	0.0	1.8	-0.1	0.9	0.7	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	3.0	0.6	1.4	-1.7	0.8	-0.6	0.4
Arm fat-free mass (left)	0.9	4.5	13.2	1.0	3.6	-1.6	0.5	-3.1	-0.3
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.6	0.5	0.1	-0.6	1.0	1.4	1.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.0	1.4	-1.3	0.4	1.7	0.6	0.2
Arm predicted mass (left)	0.9	4.4	13.8	1.2	3.7	-1.5	0.5	-3.0	-0.1
Alzheimer’s Disease (including proxy)	0.8	1.1	2.6	1.2	-0.6	1.6	-1.3	0.3	-0.8
Lung FEV1/FVC ratio	0.8	4.0	10.2	3.0	-0.0	3.2	-2.1	-0.8	-0.3
Hand grip strength (left)	0.8	2.2	3.8	1.7	2.0	-1.7	1.5	-0.9	-0.8
Diabetes (father)	0.8	1.0	1.8	-0.1	-1.3	-0.5	1.2	-0.5	-1.4
Impedance of leg (right)	0.8	3.8	12.9	-0.3	-3.6	1.9	-2.2	1.2	0.4
Current tobacco smoking	0.8	1.4	2.3	-1.2	-1.1	-1.5	-0.9	-1.1	-1.1
Maternal smoking around birth	0.8	1.1	3.8	-1.3	1.9	1.0	-0.2	-0.1	0.1
Taking other prescription medications	0.8	1.2	3.0	-0.3	0.2	1.7	0.0	1.4	-1.4
Qualifications: None of the above	0.8	1.7	3.6	-0.1	0.0	1.7	-1.9	-1.5	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.1	1.8	1.3	0.6	0.9	0.5	0.0
Fluid intelligence score	0.8	1.7	3.7	-1.9	1.3	-0.7	1.7	0.9	0.7
Number of live births	0.8	1.2	2.5	-0.1	-0.2	1.4	0.1	-1.5	-1.6
Lung cancer (father)	0.8	1.0	3.2	-1.8	1.3	-0.5	-0.2	-0.6	0.4
Forced vital capacity (FVC), Best measure	0.8	3.0	9.7	0.9	0.8	-3.1	-0.6	-2.2	1.2
Medication: Blood pressure	0.8	1.3	5.1	0.1	-0.3	-0.9	2.3	1.4	0.1
Mean time to correctly identify matches	0.8	1.4	2.5	-1.0	1.1	1.6	1.3	0.2	1.5
Knee pain experienced in last month	0.8	1.3	7.3	0.4	-0.2	2.7	-0.3	-0.5	0.1
Smoking status: Previous	0.8	1.2	2.6	0.8	-1.2	1.4	-0.4	1.6	-0.5
Back pain experienced in last month	0.8	1.1	2.5	-1.6	-0.2	1.2	-1.3	-1.0	-0.0
Guilty feelings	0.8	1.2	3.9	-0.9	2.0	0.2	1.0	1.2	-0.5
Financial situation satisfaction	0.8	1.0	4.5	0.4	0.1	2.1	-1.1	0.5	0.1
High cholesterol (Self-reported)	0.8	1.4	3.8	-0.3	-0.1	-0.2	1.1	1.7	2.0
Ever smoked	0.8	1.5	3.8	0.4	-2.0	-0.1	-0.9	0.8	-1.8
Basal metabolic rate	0.8	4.2	11.2	1.3	3.3	-1.5	0.6	-3.2	0.1
Cholesterol lowering medication	0.8	1.2	4.6	1.2	0.5	2.1	0.2	-0.7	-0.5
Worry (Nagel 2018)	0.7	1.4	2.5	-0.2	1.5	1.3	1.1	0.9	1.6
Ovarian Cancer	0.7	0.9	3.6	0.4	-0.5	0.8	-0.5	0.7	-1.9
Body Mass Index (BMI) (2010)	0.7	1.0	2.8	-0.5	-0.1	0.7	-1.7	0.0	-1.5
Hearing difficulty/problems: Yes	0.7	1.1	4.3	-0.5	-2.1	0.0	-1.1	0.5	-0.8
Leg fat-free mass (left)	0.7	3.5	9.1	1.5	2.9	-1.1	0.7	-3.0	-0.1
Arm fat percentage (right)	0.7	2.7	7.8	-0.2	-2.8	0.9	-1.5	-1.0	-2.1
Hair/balding pattern: Pattern 3	0.7	1.1	2.3	1.5	-1.3	1.1	1.2	0.0	0.1
Mouth/teeth dental problems: Dentures	0.7	1.1	3.9	-0.5	0.9	2.0	0.6	-1.0	0.8
Gout (self-reported)	0.7	0.9	2.9	1.7	-0.3	0.5	-1.0	-0.0	-1.0
Medication: Amlodipine	0.7	1.0	5.0	2.2	-0.6	-0.4	0.7	-0.1	0.4
Comparative body size at age 10	0.7	1.8	5.6	2.4	1.7	-0.1	1.2	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	4.0	-2.0	0.4	0.1	1.2	-0.5	0.1
Suffer from ‘nerves’	0.7	1.1	3.1	1.3	0.7	0.7	1.8	-0.2	1.0
Age at last live birth	0.7	1.1	2.1	-0.5	1.0	-1.4	1.0	-1.0	-1.0
Leg pain on walking	0.7	0.9	2.4	1.5	-0.2	1.6	-0.6	0.2	0.3
Supplements: Vitamin C	0.7	0.8	2.0	1.4	0.0	1.4	0.7	0.5	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	0.4	-0.6	1.4	-1.1	-0.6	-1.0
Arm fat percentage (left)	0.7	2.8	7.6	-0.3	-2.8	0.5	-1.6	-1.2	-2.3
Friendships satisfaction	0.7	0.9	2.1	-0.8	-0.0	-0.9	-0.6	1.2	1.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.7	2.2	0.1	-0.7	0.1	0.4	1.1
Osteoporosis (self-reported)	0.7	0.9	1.9	0.3	-1.4	0.9	-1.2	0.8	0.5
Leg predicted mass (right)	0.7	3.5	9.3	1.4	3.0	-1.4	0.7	-2.8	-0.0
Ever taken oral contraceptive pill	0.7	0.8	1.8	-1.3	-0.4	-0.4	-1.0	-1.3	-0.3
Medication: Lisinopril	0.7	0.9	1.7	0.0	-0.6	-1.3	1.1	0.9	-1.2
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.5	0.7	0.5	1.2	-0.6	-1.2	-1.2
Bipolar Disorder (2018)	0.6	1.0	2.5	-0.3	1.0	-0.9	0.9	-1.0	1.6
Breast Cancer	0.6	1.4	3.0	1.0	-0.1	-1.6	1.7	-0.2	1.3
Lupus	0.6	0.9	3.8	-0.3	0.0	-0.7	-0.0	-1.9	-0.9
Waist Hip Ratio (WHR)	0.6	2.8	5.1	2.1	-1.5	-1.2	-0.1	-2.3	-2.0
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	-0.2	1.1	0.5	0.8	1.1	1.2
Relative age voice broke	0.6	0.8	3.0	-0.5	-1.1	0.6	-1.7	0.3	0.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	0.6	1.0	1.1	0.7	-0.1	1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	0.3	0.5	0.9	-0.5	-0.7	-1.4
Leg predicted mass (left)	0.6	3.4	8.6	1.4	2.7	-1.2	0.7	-2.9	-0.1
Waist circumference	0.6	2.1	5.3	0.3	-1.1	-0.8	-1.1	-2.0	-2.3
Past tobacco smoking	0.6	1.1	2.1	-0.5	1.4	-0.6	1.0	-1.0	1.4
Forced vital capacity (FVC)	0.6	2.5	7.0	0.6	1.0	-2.6	-1.0	-2.2	0.8
Heart attack	0.6	0.8	1.5	0.7	0.7	1.2	-0.4	-1.0	-1.0
Medication: Simvastatin	0.6	0.8	2.1	-0.3	0.2	1.4	0.1	1.5	0.8
Falls in the last year	0.6	0.7	3.0	0.7	1.7	0.5	-0.2	0.8	0.4
Breastfed as a baby	0.6	0.8	2.7	-0.5	-0.5	0.8	-0.6	1.6	0.5
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.7	0.3	0.8	0.7	1.6	0.7	0.5
Leg fat percentage (right)	0.6	2.0	5.0	-0.4	-2.2	0.9	-1.4	-0.8	-1.9
Chest pain or discomfort	0.6	0.8	1.7	0.6	-0.6	-0.8	-1.2	-0.6	-1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	-0.4	-0.1	-0.8	0.5	1.6	0.9
Illnesses of father: Heart disease	0.6	0.8	2.4	0.8	0.2	0.2	-1.1	0.5	-1.5
Leg fat-free mass (right)	0.6	3.4	8.9	1.3	3.0	-1.4	0.7	-2.7	0.1
Average weekly red wine intake	0.6	0.8	2.1	0.8	1.4	1.3	-0.1	-0.8	-0.2
Medication: Aspirin	0.6	0.8	3.6	0.2	-0.7	0.1	0.7	1.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.5	-0.0	0.8	-1.3	-1.0	-1.9	1.2
Medication: Blood pressure	0.6	1.1	2.6	0.5	-1.2	-0.7	-1.2	-0.6	-1.6
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	0.3	-0.1	1.6	-0.8	-0.6	-1.1
Alcohol drinker status: Never	0.6	0.7	2.1	1.0	1.4	-1.0	0.4	0.3	-0.4
Leg fat percentage (left)	0.6	2.0	3.9	-0.7	-2.0	0.7	-1.8	-0.6	-1.9
Fractured/broken bones in last 5 years	0.6	0.8	2.1	0.5	1.4	1.4	-0.2	0.6	0.1
Ever depressed for a whole week	0.6	0.7	3.0	-1.7	0.5	-1.0	0.1	0.1	0.1
Alcohol drinker status: Previous	0.6	0.7	2.1	-0.7	0.5	0.7	-0.7	1.5	0.7
Schizophrenia (2018)	0.5	1.1	4.0	1.1	-2.0	0.8	-0.5	-0.5	-0.5
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.0	-0.6	1.3	-1.2	0.3	-0.4
Major Depression (MDD)	0.5	0.7	1.1	-1.1	0.6	0.2	0.8	0.9	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.3	-1.3	-0.1	-1.0	2.1	0.2	0.8
Coronary Artery Disease (CAD)	0.5	0.6	1.6	1.3	0.1	0.9	1.0	0.0	-0.6
Primary Biliary Cirrhosis	0.5	0.8	2.3	-0.8	0.5	-0.6	0.2	-1.1	-1.5
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	-0.5	-1.3	-1.0	-0.3	-0.3	0.4
Blood Platelet Count	0.5	5.5	20.2	4.5	-0.5	3.4	-0.2	1.1	0.1
Allergy or Eczema	0.5	1.2	6.1	2.5	0.8	-0.3	0.3	-0.6	0.2
Chronotype (morning person)	0.5	1.2	3.3	-0.8	1.8	-0.5	-0.0	-0.6	-1.6
Number of treatments/medications taken	0.5	1.0	2.8	-0.3	0.5	0.2	1.5	1.7	-0.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	0.8	-0.0	1.0	0.3	1.3	0.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.4	1.6	-0.5	0.3	0.4	0.1	0.7
Supplements: Zinc	0.5	0.6	1.7	-0.3	0.2	-1.0	0.5	-1.3	-0.5
Severe depression (siblings)	0.5	0.6	1.4	1.0	0.6	0.6	1.2	-0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.5	0.9	-0.4	-1.6	0.5	-0.7	-0.2
Age when periods started (menarche)	0.5	1.2	3.1	1.4	0.4	-1.8	-1.5	0.3	-0.1
Qualifications: CSEs or equivalent	0.5	0.6	1.0	-1.0	-0.8	-0.4	0.9	-0.9	-0.0
Medication: Levothyroxine sodium	0.5	0.8	1.8	0.7	0.5	1.4	-0.4	1.4	-0.5
Number of incorrect matches in round	0.5	0.9	3.4	-0.9	-0.6	0.3	-0.6	0.6	-1.8
Hair/balding pattern: Pattern 2	0.5	0.7	2.3	-0.5	-1.0	-1.5	-0.5	-0.4	0.3
Had menopause	0.5	0.6	2.0	-0.4	-0.9	1.4	0.1	0.2	-0.9
Diabetes (self-reported)	0.5	0.7	3.2	-1.8	0.5	0.1	0.7	-0.5	0.2
Medication: Ramipril	0.5	0.7	2.2	-1.5	0.5	0.8	0.9	-0.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.9	1.7	0.9	-1.3	-1.0	-2.0	0.8
Illnesses of mother	0.5	0.6	2.6	-0.2	0.7	-0.4	-1.6	-0.2	-0.4
Number of children fathered	0.5	0.5	1.7	0.6	1.3	0.2	-0.3	-0.1	0.9
Shortness of breath walking on level ground	0.5	0.6	1.3	-0.9	-0.4	1.1	-0.7	0.2	-0.7
Medication: Gliclazide	0.5	0.6	1.6	-0.8	1.0	-0.1	1.3	-0.5	0.1
Medication: Bendroflumethiazide	0.5	0.7	2.4	-0.5	-0.1	-1.5	-0.0	0.9	0.9
Pain experienced in last month	0.5	0.9	4.2	-0.2	-0.1	-2.0	1.0	0.3	-0.0
Supplements: Calcium	0.5	0.6	1.9	0.5	-0.6	-0.4	0.7	0.5	1.4
Alzheimer’s Disease (in father)	0.4	0.4	1.7	-0.4	0.1	0.7	-0.3	-0.4	-1.3
Crohns Disease (2012)	0.4	0.7	2.0	-0.5	-0.5	-0.9	-0.1	-0.9	-1.4
LDL Cholesterol	0.4	0.6	1.4	1.2	0.0	0.5	0.9	-0.9	-0.1
Neuroticism (2016)	0.4	0.6	1.7	1.3	-0.5	-0.3	0.8	0.2	0.9
Schizophrenia (2014)	0.4	0.8	1.9	0.9	-1.4	0.3	-0.1	-1.2	-0.5
Blood Eosinophil Count	0.4	2.8	8.6	0.7	-2.9	0.3	-2.2	0.4	-1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.1	-1.0	0.9	0.3	0.9	1.1	1.0
Sensitivity / hurt feelings	0.4	0.6	1.6	-0.8	0.7	-0.8	0.1	-0.6	-1.3
Diabetes (mother)	0.4	0.5	1.3	0.3	0.3	0.2	1.1	1.1	0.1
Pack years adult smoking proportion	0.4	0.6	1.3	-0.7	-0.8	-1.2	1.1	-0.3	0.0
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.8	1.7	1.0	-0.9	0.6	0.1	0.7
Multivitamins +/- minerals	0.4	0.5	2.4	0.1	0.2	1.6	-0.2	0.3	0.4
Sitting height	0.4	2.9	6.2	1.5	2.5	-1.0	-0.2	-2.5	1.4
Trunk fat mass	0.4	1.6	3.6	0.1	-1.9	0.5	-1.6	-1.1	-1.4
Hearing difficulty/problems with background noise	0.4	0.7	2.9	-0.1	-0.4	-0.1	0.5	-0.9	-1.7
Asthma	0.4	0.8	2.8	-1.7	0.1	-0.3	1.1	0.7	-0.6
Medication: Lansoprazole	0.4	0.5	1.5	-0.7	0.5	-0.1	-0.6	0.6	-1.2
Arm fat mass (right)	0.4	1.5	3.2	0.4	-1.2	0.0	-1.0	-1.8	-1.8
Tense / ‘highly strung’	0.4	0.6	1.4	-0.6	1.2	0.6	-0.6	0.9	-0.6
Birth weight of first child	0.4	0.7	1.8	-0.2	1.0	0.2	1.0	-0.6	-1.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	0.3	1.0	1.0	-0.3	0.3	0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	-0.7	0.8	1.5	-0.8	0.8	-0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	0.5	-0.1	0.3	1.1	-0.8	-1.1
Worry too long after embarrassment	0.4	0.7	1.5	0.2	-1.0	-0.5	1.2	1.0	-0.2
Wheeze or whistling in the chest in last year	0.4	0.7	3.4	-0.8	-1.9	0.1	0.5	0.1	-0.1
Age at first live birth	0.4	0.7	2.3	-0.5	0.5	-1.3	1.5	0.1	0.2
Leg fat mass (right)	0.4	1.5	3.7	0.4	-0.8	-0.1	-1.2	-1.9	-1.8
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	-0.3	-1.0	-1.2	0.2	-0.2	-0.7
Loneliness, isolation	0.4	0.6	1.0	-0.7	-0.4	1.0	0.6	-0.9	-0.9
Diabetes diagnosed by doctor	0.4	0.6	2.6	-1.6	0.7	0.4	0.5	0.1	-0.6
Medication for cholesterol	0.4	0.6	1.7	-1.3	0.0	-0.9	0.1	0.6	0.8
Mineral and other dietary supplements	0.4	0.5	1.9	-0.1	-0.6	-1.4	0.2	0.2	0.8
Asthma (self-reported)	0.4	0.8	2.2	-1.5	0.1	-0.7	1.1	0.4	-0.7
Osteoarthritis (self-reported)	0.4	0.5	1.6	0.1	1.3	0.8	-0.1	-0.4	-0.8
Wears glasses or contact lenses	0.4	0.4	1.3	0.2	1.1	-0.1	-0.5	0.7	0.7
Depression (Nagel 2018)	0.3	0.5	1.1	0.5	-1.0	-1.1	0.5	0.5	-0.4
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.8	-1.1	0.0	-0.0	-0.7	0.4
Crohns Disease (2017)	0.3	0.6	1.2	-1.1	-0.4	-0.2	-0.7	-0.9	-1.0
Fasting Glucose	0.3	0.3	0.9	-1.0	0.6	-0.7	0.4	-0.1	0.0
Ulcerative Colitis	0.3	0.5	1.5	-0.1	-0.7	-0.3	0.6	0.7	-1.2
Height	0.3	6.3	14.2	3.1	3.8	-0.4	0.4	-2.5	2.7
Systolic Blood Pressure	0.3	1.4	2.9	1.6	-1.7	-1.5	0.8	0.6	0.1
Lung FVC	0.3	1.4	3.6	-1.6	1.3	-1.9	-0.3	-0.3	0.5
Neuroticism	0.3	0.7	1.9	-0.2	0.9	0.9	0.7	1.4	0.2
Fed-up feelings	0.3	0.5	1.3	0.7	-0.5	0.5	-0.3	1.1	0.8
Supplements: Glucosamine	0.3	0.3	1.3	0.1	-0.5	1.2	0.5	-0.0	-0.4
Medication: Atenolol	0.3	0.4	0.6	-0.5	-0.0	-0.8	0.7	0.7	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	0.8	-0.9	-0.7	-0.6	1.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.9	0.7	-0.5	0.0	0.5	-0.3
Mouth/teeth dental problems	0.3	0.4	2.3	-0.2	-0.1	-1.5	-0.5	-0.1	-0.3
Allergy	0.3	0.6	1.5	-1.2	0.2	0.9	-1.0	0.2	-0.2
Hip circumference	0.3	1.1	3.2	-0.5	0.0	0.3	-1.4	-1.8	-1.2
Happiness	0.3	0.3	0.8	0.1	-0.1	0.9	-0.7	-0.1	0.9
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	-0.7	0.4	1.2	0.2	0.1	-1.3
Standing height	0.3	3.3	6.5	2.2	2.1	-1.0	-0.5	-1.7	2.6
Length of working week for main job	0.3	0.4	1.4	0.4	0.0	-0.3	-0.7	-1.2	-0.3
Hair/balding pattern: Pattern 4	0.3	0.8	3.3	-0.0	1.8	0.6	0.7	-0.7	0.4
Peak expiratory flow (PEF)	0.3	0.8	3.7	1.9	0.2	0.1	-1.0	0.3	-0.2
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	-0.1	-0.7	0.3	0.2	-1.0	-0.8
Birth weight	0.3	0.7	2.0	-1.0	0.3	0.0	-0.9	-1.4	-0.7
Medication: Ibuprofen	0.3	0.3	1.0	0.3	0.4	0.8	0.2	1.0	0.1
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.9	-0.3	0.4	-0.8	0.1	-0.5
Whole body fat mass	0.3	1.5	2.6	0.4	-1.4	0.4	-1.4	-1.6	-1.5
Pulse rate, automated reading	0.3	1.0	3.5	-0.5	-1.2	0.8	-0.3	-1.9	-0.1
Comparative height size at age 10	0.3	1.7	5.1	1.2	1.1	-0.3	-0.4	-2.2	1.4
Family relationship satisfaction	0.3	0.3	0.9	-0.5	0.2	-1.0	0.4	-0.8	0.3
Hypertension (Self-reported)	0.3	0.8	2.3	1.1	-0.5	-1.5	0.7	0.6	0.4
Ever had bowel cancer screening	0.3	0.4	1.2	0.4	-0.5	0.6	-0.2	1.1	0.4
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.2	0.1	-1.0	0.1	0.4	-1.1
Arm fat mass (left)	0.3	1.4	3.6	0.2	-1.0	-0.2	-1.0	-1.9	-1.7
Number of self-reported non-cancer illnesses	0.3	0.6	2.0	0.5	-0.2	0.5	0.8	1.4	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.3	-0.8	-1.0	-0.2	0.0	0.4
Medication: Paracetamol	0.3	0.4	2.3	-0.0	-1.5	0.2	0.1	0.3	0.1
Unable to work because of sickness or disability	0.3	0.4	1.3	0.2	1.0	1.1	0.1	-0.0	0.6
Heart disease (siblings)	0.3	0.4	1.0	-0.1	-1.0	0.5	0.1	-0.3	-0.9
Pack years of smoking	0.3	0.5	1.0	-0.7	-1.0	-0.8	0.9	-0.3	-0.1
Leg fat mass (left)	0.3	1.3	2.9	0.2	-0.5	-0.2	-1.3	-1.7	-1.7
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.7	-1.0	0.1	0.1	-1.0	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.1	-1.8	-0.2	-0.8	0.4	-0.1	0.3
Neuroticism (Nagel 2018)	0.2	0.5	1.7	-0.2	0.0	0.0	0.4	1.3	1.0
HDL Cholesterol	0.2	0.3	1.3	0.3	-1.2	-0.2	-0.3	-0.1	-0.2
Heel T-Score	0.2	1.3	3.4	1.8	0.7	1.3	-0.3	1.0	1.0
BMI	0.2	1.3	5.0	-0.5	-0.0	-0.5	-0.2	-1.5	-2.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	-0.1	-0.1	0.5	0.4	0.9	-0.2
Systolic blood pressure, automated reading	0.2	0.6	1.3	0.1	-1.2	0.0	1.0	-0.1	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	0.4	-0.0	-1.0	-0.9	0.4	-0.3
High blood pressure	0.2	0.6	1.9	1.1	-0.7	-1.4	0.4	0.2	0.3
Body mass index (BMI)	0.2	0.9	3.4	-0.2	-0.4	-0.4	-0.3	-1.2	-1.8
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.8	0.9	0.5	-0.2	-0.5	0.1
Weight	0.2	0.9	3.4	0.7	0.5	-0.8	-0.7	-1.8	-0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.4	0.3	-0.4	-0.4	0.3	-1.2	-0.3
Worrier / anxious feelings	0.2	0.4	1.5	-1.2	0.9	0.5	0.1	0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.1	0.0	0.5	0.2	-0.3	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	-0.4	-0.8	-0.0	-0.1	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.8	0.2	-0.4	0.8	-0.1	-0.9
Medication: Paracetamol	0.2	0.3	1.4	0.1	-1.2	0.4	-0.5	0.1	0.1
Qualifications: College or University degree	0.2	0.7	2.2	1.5	0.1	0.7	-0.3	1.0	-0.7
Long-standing illness, disability or infirmity	0.2	0.3	0.9	0.3	0.6	0.9	0.5	0.2	0.2
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.6	0.3	0.1	0.4	1.1	0.1
Mother’s age at death	0.2	0.3	1.5	1.2	-0.1	-0.2	0.4	-0.2	-0.1
Commuting to job workplace: Public transport	0.2	0.3	1.0	0.5	0.1	-1.0	0.5	0.2	0.2
Irritability	0.2	0.4	0.6	-0.8	-0.7	-0.2	-0.2	0.8	-0.7
Diastolic blood pressure, automated reading	0.2	0.8	2.2	-0.0	-1.3	0.4	0.2	-0.5	-1.5
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	-1.0	1.1	1.1	0.0	0.2	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.0	-0.3	-0.5	-0.0	0.8	0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.5	-0.1	0.3	0.1	-0.4	-0.7
Prostate Cancer	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.2	0.2	0.4
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.2	0.3	-0.5	-0.2	0.0	0.0
Rheumatoid Arthritis	0.1	0.1	0.3	0.0	0.1	0.6	-0.4	-0.3	-0.0
Triglycerides	0.1	0.2	0.9	-0.2	0.2	0.1	0.0	-0.0	1.0
Hypothyroidism (self reported)	0.1	0.3	1.1	-0.6	0.2	1.0	-0.3	0.0	0.4
Respiratory disease	0.1	0.2	0.5	-0.7	0.3	-0.1	0.6	-0.2	-0.5
Tanning	0.1	0.7	1.8	-1.2	-0.0	-0.7	-0.6	-1.3	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.8	-0.3	0.0	0.9	-0.4	-0.1	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	0.9	0.2	-0.4	0.3	0.1	0.2
Neuroticism score	0.1	0.2	0.6	-0.6	0.1	0.2	0.5	0.8	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.4	-0.5	0.6	0.1	0.3	-0.0
Number of full brothers	0.1	0.1	0.1	-0.4	0.3	0.1	0.2	-0.3	0.3
Alcohol intake frequency.	0.1	0.3	0.8	-0.9	0.6	0.3	0.7	0.4	-0.2
Mood swings	0.1	0.2	0.7	-0.1	-0.6	-0.8	-0.3	-0.1	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.0	-0.4	-0.3	0.3	0.5	0.6
Miserableness	0.1	0.2	0.5	-0.2	0.1	0.6	0.3	0.5	-0.7
Age started oral contraceptive pill	0.1	0.2	0.8	0.9	-0.2	0.6	-0.1	-0.1	-0.0
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.2	0.4	0.0	0.4	0.2	-0.4
Blood Red Count	0.0	0.3	0.7	0.8	-0.2	-0.3	-0.1	-0.4	0.8
Blood White Count	0.0	0.3	1.0	-1.0	-0.0	-0.1	0.1	0.8	0.5
Hair Pigment	0.0	0.6	1.4	0.9	-0.0	-1.2	0.2	-0.2	-1.0

Hub : Genes

RIN2

Models

Trait associations