Hub : Genes

RIN2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0920	0.0340	0.00490	0.012	0.011	0.004	0.011	0.013	0.013	0.01500	0.0970	0.0150	0.0078
2	GTEx	Artery Aorta	0.1440	0.0540	0.00650	0.010	NA	0.010	NA	0.008	0.090	NA	0.0850	NA	0.1100
3	GTEx	Esophagus Mucosa	0.1170	0.0450	0.00820	0.000	NA	0.009	NA	0.004	0.310	NA	0.0780	NA	0.1700
4	YFS	Blood	0.0473	0.0148	0.00013	-0.001	0.005	0.007	0.005	0.000	0.760	0.00780	0.0023	0.0084	0.5100
5	TCGA	Breast Invasive Carcinoma	0.0382	0.0150	0.00190	-0.001	0.018	0.006	NA	0.000	0.650	0.00012	0.0190	NA	0.2500
6	TCGA	Prostate Adenocarcinoma	0.0530	0.0233	0.00900	0.003	0.020	-0.002	NA	0.000	0.150	0.00280	0.6500	NA	0.3300

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.6	1.0	2.5	-0.3	1.0	-0.9	0.9	-1.0	1.6
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.7	-1.0	0.1	0.1	-1.0	0.6
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.0	-0.3	-0.5	-0.0	0.8	0.2
Depression (Nagel 2018)	0.3	0.5	1.1	0.5	-1.0	-1.1	0.5	0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.2	0.7	3.1	-1.8	-0.2	-0.8	0.4	-0.1	0.3
Neuroticism (Nagel 2018)	0.2	0.5	1.7	-0.2	0.0	0.0	0.4	1.3	1.0
Schizophrenia (2018)	0.5	1.1	4.0	1.1	-2.0	0.8	-0.5	-0.5	-0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	1.2	0.8	-1.1	0.0	-0.0	-0.7	0.4
Worry (Nagel 2018)	0.7	1.4	2.5	-0.2	1.5	1.3	1.1	0.9	1.6
Alzheimer’s Disease (in mother)	0.5	0.6	1.7	-0.0	-0.6	1.3	-1.2	0.3	-0.4
Alzheimer’s Disease (in father)	0.4	0.4	1.7	-0.4	0.1	0.7	-0.3	-0.4	-1.3
Alzheimer’s Disease (including proxy)	0.8	1.1	2.6	1.2	-0.6	1.6	-1.3	0.3	-0.8
Crohns Disease (2017)	0.3	0.6	1.2	-1.1	-0.4	-0.2	-0.7	-0.9	-1.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.5	-0.1	0.3	0.1	-0.4	-0.7
Ulcerative Colitis (UC)	0.0	0.1	0.2	-0.2	0.4	0.0	0.4	0.2	-0.4
Major Depression (MDD)	0.5	0.7	1.1	-1.1	0.6	0.2	0.8	0.9	1.0
Reaction Time	1.0	1.8	4.2	-0.6	2.0	1.0	1.2	-0.2	2.0
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.3	-1.3	-0.1	-1.0	2.1	0.2	0.8
Breast Cancer	0.6	1.4	3.0	1.0	-0.1	-1.6	1.7	-0.2	1.3
Ovarian Cancer	0.7	0.9	3.6	0.4	-0.5	0.8	-0.5	0.7	-1.9
Prostate Cancer	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.2	0.2	0.4
Age at First Birth	1.2	1.7	3.7	1.6	1.2	-1.9	0.0	-1.4	0.6
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.2	0.3	-0.5	-0.2	0.0	0.0
Body Mass Index (BMI) (2010)	0.7	1.0	2.8	-0.5	-0.1	0.7	-1.7	0.0	-1.5
Coronary Artery Disease (CAD)	0.5	0.6	1.6	1.3	0.1	0.9	1.0	0.0	-0.6
Crohns Disease (2012)	0.4	0.7	2.0	-0.5	-0.5	-0.9	-0.1	-0.9	-1.4
Mean Putamen Volume	1.3	1.5	4.2	-1.6	1.4	0.2	0.4	0.5	-2.0
Fasting Glucose	0.3	0.3	0.9	-1.0	0.6	-0.7	0.4	-0.1	0.0
HbA1C	1.1	1.2	3.6	-1.0	0.7	-1.3	1.9	0.2	0.7
HDL Cholesterol	0.2	0.3	1.3	0.3	-1.2	-0.2	-0.3	-0.1	-0.2
LDL Cholesterol	0.4	0.6	1.4	1.2	0.0	0.5	0.9	-0.9	-0.1
Lupus	0.6	0.9	3.8	-0.3	0.0	-0.7	-0.0	-1.9	-0.9
Neuroticism (2016)	0.4	0.6	1.7	1.3	-0.5	-0.3	0.8	0.2	0.9
Primary Biliary Cirrhosis	0.5	0.8	2.3	-0.8	0.5	-0.6	0.2	-1.1	-1.5
Rheumatoid Arthritis	0.1	0.1	0.3	0.0	0.1	0.6	-0.4	-0.3	-0.0
Schizophrenia (2014)	0.4	0.8	1.9	0.9	-1.4	0.3	-0.1	-1.2	-0.5
Triglycerides	0.1	0.2	0.9	-0.2	0.2	0.1	0.0	-0.0	1.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.7	-0.5	-1.3	-1.0	-0.3	-0.3	0.4
Ulcerative Colitis	0.3	0.5	1.5	-0.1	-0.7	-0.3	0.6	0.7	-1.2
Blood Eosinophil Count	0.4	2.8	8.6	0.7	-2.9	0.3	-2.2	0.4	-1.6
Blood Platelet Count	0.5	5.5	20.2	4.5	-0.5	3.4	-0.2	1.1	0.1
Blood Red Count	0.0	0.3	0.7	0.8	-0.2	-0.3	-0.1	-0.4	0.8
Blood White Count	0.0	0.3	1.0	-1.0	-0.0	-0.1	0.1	0.8	0.5
Heel T-Score	0.2	1.3	3.4	1.8	0.7	1.3	-0.3	1.0	1.0
BMI	0.2	1.3	5.0	-0.5	-0.0	-0.5	-0.2	-1.5	-2.2
Height	0.3	6.3	14.2	3.1	3.8	-0.4	0.4	-2.5	2.7
Waist Hip Ratio (WHR)	0.6	2.8	5.1	2.1	-1.5	-1.2	-0.1	-2.3	-2.0
Systolic Blood Pressure	0.3	1.4	2.9	1.6	-1.7	-1.5	0.8	0.6	0.1
Smoking Status	1.2	2.8	5.1	-0.8	-1.7	-1.8	-2.2	-0.4	-2.3
Allergy or Eczema	0.5	1.2	6.1	2.5	0.8	-0.3	0.3	-0.6	0.2
Cardiovascular Disease	1.0	3.3	8.1	2.2	-1.4	-2.8	1.6	1.0	1.4
Hypothyroidism (self reported)	0.1	0.3	1.1	-0.6	0.2	1.0	-0.3	0.0	0.4
Respiratory disease	0.1	0.2	0.5	-0.7	0.3	-0.1	0.6	-0.2	-0.5
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.1	-1.0	0.9	0.3	0.9	1.1	1.0
Lung FEV1/FVC ratio	0.8	4.0	10.2	3.0	-0.0	3.2	-2.1	-0.8	-0.3
Lung FVC	0.3	1.4	3.6	-1.6	1.3	-1.9	-0.3	-0.3	0.5
Neuroticism	0.3	0.7	1.9	-0.2	0.9	0.9	0.7	1.4	0.2
Chronotype (morning person)	0.5	1.2	3.3	-0.8	1.8	-0.5	-0.0	-0.6	-1.6
Hair Pigment	0.0	0.6	1.4	0.9	-0.0	-1.2	0.2	-0.2	-1.0
Tanning	0.1	0.7	1.8	-1.2	-0.0	-0.7	-0.6	-1.3	-0.2
Hand grip strength (left)	0.8	2.2	3.8	1.7	2.0	-1.7	1.5	-0.9	-0.8
Number of treatments/medications taken	0.5	1.0	2.8	-0.3	0.5	0.2	1.5	1.7	-0.5
Average weekly spirits intake	0.9	1.1	4.3	0.8	0.1	0.4	0.5	-1.0	-2.1
Sensitivity / hurt feelings	0.4	0.6	1.6	-0.8	0.7	-0.8	0.1	-0.6	-1.3
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.9	-0.1	-0.1	0.5	0.4	0.9	-0.2
Hearing difficulty/problems: Yes	0.7	1.1	4.3	-0.5	-2.1	0.0	-1.1	0.5	-0.8
Relative age of first facial hair	1.1	2.3	7.2	-0.1	-2.7	-0.0	-0.9	2.1	1.2
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.7	0.8	-0.0	1.0	0.3	1.3	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.5	-0.2	1.1	0.5	0.8	1.1	1.2
Ever had hysterectomy (womb removed)	0.5	0.6	2.4	1.6	-0.5	0.3	0.4	0.1	0.7
Systolic blood pressure, automated reading	0.2	0.6	1.3	0.1	-1.2	0.0	1.0	-0.1	-1.0
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	10.1	-0.3	3.2	0.6	1.9	-0.7	0.5
Angina	1.0	1.3	3.9	2.0	-1.1	1.6	0.1	0.3	0.0
Medication for hormone replacement therapy	1.3	1.4	4.4	0.2	2.1	2.0	0.2	-0.2	-0.0
Vitamin and mineral supplements	1.0	1.3	5.5	-1.0	-0.9	-2.4	-0.4	-0.6	0.4
Supplements: Zinc	0.5	0.6	1.7	-0.3	0.2	-1.0	0.5	-1.3	-0.5
Medication: Co-codamol	1.2	1.4	4.7	-0.5	-0.5	1.2	-0.4	-1.2	-2.2
Medication: Metformin	1.6	2.3	4.9	-2.2	1.4	0.9	1.6	-0.1	-1.9
Diabetes (father)	0.8	1.0	1.8	-0.1	-1.3	-0.5	1.2	-0.5	-1.4
Diabetes (mother)	0.4	0.5	1.3	0.3	0.3	0.2	1.1	1.1	0.1
Severe depression (siblings)	0.5	0.6	1.4	1.0	0.6	0.6	1.2	-0.5	0.3
Pack years adult smoking proportion	0.4	0.6	1.3	-0.7	-0.8	-1.2	1.1	-0.3	0.0
Impedance of leg (right)	0.8	3.8	12.9	-0.3	-3.6	1.9	-2.2	1.2	0.4
Leg fat-free mass (left)	0.7	3.5	9.1	1.5	2.9	-1.1	0.7	-3.0	-0.1
Trunk fat percentage	1.0	3.8	13.7	-0.1	-3.7	1.2	-2.2	-0.3	-1.7
Hand grip strength (right)	1.0	2.6	5.9	0.9	1.7	-2.4	2.3	-0.7	-0.2
Townsend deprivation index at recruitment	0.1	0.2	0.8	-0.3	0.0	0.9	-0.4	-0.1	-0.0
Current tobacco smoking	0.8	1.4	2.3	-1.2	-1.1	-1.5	-0.9	-1.1	-1.1
Average weekly fortified wine intake	1.6	1.9	5.3	0.1	2.3	-0.5	-1.8	-0.5	-1.5
Maternal smoking around birth	0.8	1.1	3.8	-1.3	1.9	1.0	-0.2	-0.1	0.1
Fed-up feelings	0.3	0.5	1.3	0.7	-0.5	0.5	-0.3	1.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.5	0.9	-0.4	-1.6	0.5	-0.7	-0.2
Relative age voice broke	0.6	0.8	3.0	-0.5	-1.1	0.6	-1.7	0.3	0.0
Taking other prescription medications	0.8	1.2	3.0	-0.3	0.2	1.7	0.0	1.4	-1.4
Age when periods started (menarche)	0.5	1.2	3.1	1.4	0.4	-1.8	-1.5	0.3	-0.1
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.2	0.6	1.0	1.1	0.7	-0.1	1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.1	0.4	-0.0	-1.0	-0.9	0.4	-0.3
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.9	0.3	0.5	0.9	-0.5	-0.7	-1.4
Qualifications: CSEs or equivalent	0.5	0.6	1.0	-1.0	-0.8	-0.4	0.9	-0.9	-0.0
Serious illness, injury or assault to yourself	0.9	1.1	1.4	1.2	1.2	1.1	-0.5	-1.2	-1.0
High blood pressure	0.2	0.6	1.9	1.1	-0.7	-1.4	0.4	0.2	0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.8	1.7	1.0	-0.9	0.6	0.1	0.7
Multivitamins +/- minerals	0.4	0.5	2.4	0.1	0.2	1.6	-0.2	0.3	0.4
Stomach or abdominal pain in last month	0.9	1.1	2.1	-1.0	1.1	1.3	-0.9	-0.1	-1.4
Supplements: Glucosamine	0.3	0.3	1.3	0.1	-0.5	1.2	0.5	-0.0	-0.4
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.1	0.2	1.0	1.0	0.9	-1.2	-2.0
Medication: Atenolol	0.3	0.4	0.6	-0.5	-0.0	-0.8	0.7	0.7	-0.7
Medication: Levothyroxine sodium	0.5	0.8	1.8	0.7	0.5	1.4	-0.4	1.4	-0.5
Sitting height	0.4	2.9	6.2	1.5	2.5	-1.0	-0.2	-2.5	1.4
Chronic bronchitis/emphysema (father)	1.1	1.3	2.9	-0.8	-0.7	1.2	-1.6	0.3	-1.7
High blood pressure (mother)	1.4	2.0	8.3	0.8	-0.1	-0.0	2.9	0.3	1.7
Body mass index (BMI)	0.2	0.9	3.4	-0.2	-0.4	-0.4	-0.3	-1.2	-1.8
Impedance of leg (left)	0.9	4.3	11.8	-0.7	-3.4	1.7	-2.7	1.7	0.4
Leg predicted mass (left)	0.6	3.4	8.6	1.4	2.7	-1.2	0.7	-2.9	-0.1
Trunk fat mass	0.4	1.6	3.6	0.1	-1.9	0.5	-1.6	-1.1	-1.4
Waist circumference	0.6	2.1	5.3	0.3	-1.1	-0.8	-1.1	-2.0	-2.3
Number of incorrect matches in round	0.5	0.9	3.4	-0.9	-0.6	0.3	-0.6	0.6	-1.8
Past tobacco smoking	0.6	1.1	2.1	-0.5	1.4	-0.6	1.0	-1.0	1.4
Alcohol usually taken with meals	1.2	1.9	4.3	2.1	1.5	1.9	-0.0	0.9	-0.6
Nervous feelings	0.9	1.7	6.3	0.3	2.5	0.9	0.8	-0.4	1.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.9	0.9	0.2	-0.4	0.3	0.1	0.2
Hearing difficulty/problems with background noise	0.4	0.7	2.9	-0.1	-0.4	-0.1	0.5	-0.9	-1.7
Hair/balding pattern: Pattern 2	0.5	0.7	2.3	-0.5	-1.0	-1.5	-0.5	-0.4	0.3
Had menopause	0.5	0.6	2.0	-0.4	-0.9	1.4	0.1	0.2	-0.9
Had other major operations	1.0	1.3	2.9	-0.2	0.8	1.6	-1.2	0.0	-1.7
Forced vital capacity (FVC)	0.6	2.5	7.0	0.6	1.0	-2.6	-1.0	-2.2	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.4	0.8	-0.9	-0.7	-0.6	1.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.8	-0.9	0.7	-0.5	0.0	0.5	-0.3
Qualifications: None of the above	0.8	1.7	3.6	-0.1	0.0	1.7	-1.9	-1.5	1.2
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.8	0.9	0.5	-0.2	-0.5	0.1
Mouth/teeth dental problems	0.3	0.4	2.3	-0.2	-0.1	-1.5	-0.5	-0.1	-0.3
Heart attack	0.6	0.8	1.5	0.7	0.7	1.2	-0.4	-1.0	-1.0
Allergy	0.3	0.6	1.5	-1.2	0.2	0.9	-1.0	0.2	-0.2
Pain all over the body in last month	1.3	1.4	3.9	1.6	0.7	0.1	2.0	0.3	1.2
Diabetes (self-reported)	0.5	0.7	3.2	-1.8	0.5	0.1	0.7	-0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	3.1	1.8	1.3	0.6	0.9	0.5	0.0
Medication: Ramipril	0.5	0.7	2.2	-1.5	0.5	0.8	0.9	-0.3	0.0
Medication: Simvastatin	0.6	0.8	2.1	-0.3	0.2	1.4	0.1	1.5	0.8
Fluid intelligence score	0.8	1.7	3.7	-1.9	1.3	-0.7	1.7	0.9	0.7
Illnesses of siblings	1.0	1.5	4.1	-0.2	2.0	-0.2	-1.8	-1.0	-0.5
Neuroticism score	0.1	0.2	0.6	-0.6	0.1	0.2	0.5	0.8	-0.4
Weight	0.2	0.9	3.4	0.7	0.5	-0.8	-0.7	-1.8	-0.7
Impedance of arm (right)	1.5	7.0	26.0	0.3	-5.1	2.5	-2.3	1.9	0.6
Arm fat percentage (right)	0.7	2.7	7.8	-0.2	-2.8	0.9	-1.5	-1.0	-2.1
Trunk fat-free mass	1.2	7.1	23.8	1.3	4.9	-1.6	1.3	-3.4	0.7
Hip circumference	0.3	1.1	3.2	-0.5	0.0	0.3	-1.4	-1.8	-1.2
Time employed in main current job	1.4	1.7	3.3	1.3	1.8	0.9	-0.3	-1.7	1.1
Alcohol intake versus 10 years previously	0.2	0.3	1.4	0.3	-0.4	-0.4	0.3	-1.2	-0.3
Father’s age at death	1.0	1.3	3.0	1.7	0.9	1.2	-0.5	1.5	-0.4
Worrier / anxious feelings	0.2	0.4	1.5	-1.2	0.9	0.5	0.1	0.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	-0.1	0.0	0.5	0.2	-0.3	-1.1
Falls in the last year	0.6	0.7	3.0	0.7	1.7	0.5	-0.2	0.8	0.4
Hair/balding pattern: Pattern 3	0.7	1.1	2.3	1.5	-1.3	1.1	1.2	0.0	0.1
Number of live births	0.8	1.2	2.5	-0.1	-0.2	1.4	0.1	-1.5	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	3.9	1.7	0.9	-1.3	-1.0	-2.0	0.8
Pulse rate	1.7	2.9	6.1	1.6	-1.3	2.1	-1.4	-2.5	-0.7
Happiness	0.3	0.3	0.8	0.1	-0.1	0.9	-0.7	-0.1	0.9
Noisy workplace	1.3	1.6	4.1	1.7	-0.8	-0.4	-1.1	-2.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.3	0.6	1.7	-0.7	0.4	1.2	0.2	0.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	-0.4	-0.8	-0.0	-0.1	-0.1	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.1	3.9	-0.5	0.9	2.0	0.6	-1.0	0.8
Asthma	0.4	0.8	2.8	-1.7	0.1	-0.3	1.1	0.7	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.4	-0.5	0.6	0.1	0.3	-0.0
Medication: Cholesterol lowering	1.2	1.9	5.1	-0.2	0.2	-0.4	1.6	2.3	1.8
Depression (self-reported)	0.9	1.1	3.2	-0.5	1.6	0.0	1.8	0.7	0.5
Medication: Lansoprazole	0.4	0.5	1.5	-0.7	0.5	-0.1	-0.6	0.6	-1.2
Prospective memory result	1.0	1.3	3.8	0.4	0.2	1.4	-1.0	-2.0	-0.8
Lung cancer (father)	0.8	1.0	3.2	-1.8	1.3	-0.5	-0.2	-0.6	0.4
Illnesses of mother	0.5	0.6	2.6	-0.2	0.7	-0.4	-1.6	-0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	5.3	2.3	0.5	-2.0	-1.0	-2.2	1.1
Pulse wave Arterial Stiffness index	2.8	3.3	8.1	2.9	-1.2	-1.9	-1.6	-1.3	1.5
Impedance of arm (left)	1.4	6.7	26.3	0.3	-5.1	1.9	-2.8	1.5	0.4
Arm fat mass (right)	0.4	1.5	3.2	0.4	-1.2	0.0	-1.0	-1.8	-1.8
Trunk predicted mass	1.2	7.0	22.8	1.3	4.8	-1.7	1.3	-3.5	0.8
Standing height	0.3	3.3	6.5	2.2	2.1	-1.0	-0.5	-1.7	2.6
Length of working week for main job	0.3	0.4	1.4	0.4	0.0	-0.3	-0.7	-1.2	-0.3
Exposure to tobacco smoke at home	1.0	1.1	4.1	0.5	2.0	-0.1	-1.2	-0.6	0.5
Breastfed as a baby	0.6	0.8	2.7	-0.5	-0.5	0.8	-0.6	1.6	0.5
Tense / ‘highly strung’	0.4	0.6	1.4	-0.6	1.2	0.6	-0.6	0.9	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.8	0.2	-0.4	0.8	-0.1	-0.9
Hair/balding pattern: Pattern 4	0.3	0.8	3.3	-0.0	1.8	0.6	0.7	-0.7	0.4
Birth weight of first child	0.4	0.7	1.8	-0.2	1.0	0.2	1.0	-0.6	-1.4
Peak expiratory flow (PEF)	0.3	0.8	3.7	1.9	0.2	0.1	-1.0	0.3	-0.2
Pulse wave reflection index	1.2	1.5	6.4	1.1	-0.5	-2.5	-0.6	0.0	1.0
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.1	0.3	1.0	1.0	-0.3	0.3	0.9
Loud music exposure frequency	1.2	1.4	3.6	-0.7	-1.9	0.7	-1.6	0.4	0.9
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.7	-2.2	-0.1	-1.6	1.1	0.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	-0.1	-0.7	0.3	0.2	-1.0	-0.8
Blood clot in the leg (DVT)	1.0	1.3	2.8	1.7	-1.2	0.7	1.5	0.6	0.5
Medication: Paracetamol	0.2	0.3	1.4	0.1	-1.2	0.4	-0.5	0.1	0.1
Headache pain in last month	0.9	1.6	2.8	-0.7	-1.1	0.0	-1.7	1.4	-1.7
Medication for cholesterol, blood pressure or diabetes	1.6	2.6	6.1	0.4	0.2	2.0	-2.5	-1.7	-1.6
Glaucoma (self-reported)	1.2	1.4	4.6	-0.1	0.6	-2.1	0.6	-1.7	-0.3
Gout (self-reported)	0.7	0.9	2.9	1.7	-0.3	0.5	-1.0	-0.0	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	-0.7	0.8	1.5	-0.8	0.8	-0.4
Medication: Amlodipine	0.7	1.0	5.0	2.2	-0.6	-0.4	0.7	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.4	0.6	1.2	0.5	-0.1	0.3	1.1	-0.8	-1.1
Birth weight	0.3	0.7	2.0	-1.0	0.3	0.0	-0.9	-1.4	-0.7
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.7	0.3	0.8	0.7	1.6	0.7	0.5
High blood pressure (siblings)	1.0	1.5	3.7	0.2	-1.6	-0.6	1.9	1.5	-0.2
Forced vital capacity (FVC), Best measure	0.8	3.0	9.7	0.9	0.8	-3.1	-0.6	-2.2	1.2
Body fat percentage	0.9	3.7	11.8	-0.1	-3.4	1.1	-2.2	-0.7	-2.0
Leg fat percentage (right)	0.6	2.0	5.0	-0.4	-2.2	0.9	-1.4	-0.8	-1.9
Arm fat-free mass (right)	0.9	4.6	14.2	1.0	3.8	-1.6	0.6	-3.0	0.1
Exposure to tobacco smoke outside home	2.1	2.8	7.2	-2.1	0.7	-1.8	2.7	-0.2	0.9
Comparative body size at age 10	0.7	1.8	5.6	2.4	1.7	-0.1	1.2	-0.8	-0.6
Number of full brothers	0.1	0.1	0.1	-0.4	0.3	0.1	0.2	-0.3	0.3
Worry too long after embarrassment	0.4	0.7	1.5	0.2	-1.0	-0.5	1.2	1.0	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	4.0	-2.0	0.4	0.1	1.2	-0.5	0.1
Wheeze or whistling in the chest in last year	0.4	0.7	3.4	-0.8	-1.9	0.1	0.5	0.1	-0.1
Number of children fathered	0.5	0.5	1.7	0.6	1.3	0.2	-0.3	-0.1	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.2	0.7	0.6	0.1	0.9	1.1	2.0
Age at first live birth	0.4	0.7	2.3	-0.5	0.5	-1.3	1.5	0.1	0.2
Pulse wave peak to peak time	2.5	3.0	6.8	-2.6	1.6	1.7	1.7	1.3	-1.1
Health satisfaction	1.8	2.3	4.2	-1.2	-2.0	1.6	-1.8	-1.3	-0.9
Shortness of breath walking on level ground	0.5	0.6	1.3	-0.9	-0.4	1.1	-0.7	0.2	-0.7
Qualifications: College or University degree	0.2	0.7	2.2	1.5	0.1	0.7	-0.3	1.0	-0.7
Eye problems/disorders: None of the above	1.7	1.9	4.9	-0.6	-2.2	1.0	-1.0	1.1	1.7
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.0	-1.7	-1.2	0.8	0.1	1.5	-0.5
Emphysema/chronic bronchitis	1.3	1.4	3.8	-1.5	-0.6	0.2	1.0	-1.9	1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	3.5	-0.4	1.7	-1.3	-0.7	-1.9	0.5
Neck or shoulder pain in last month	1.9	2.7	4.6	0.5	-1.8	2.1	-2.1	-1.0	-1.7
Medication: Blood pressure	0.8	1.3	5.1	0.1	-0.3	-0.9	2.3	1.4	0.1
Angina (self-reported)	0.9	1.2	3.7	1.9	-0.9	1.5	0.1	0.6	0.3
Migraine (self-reported)	1.4	1.7	4.1	-1.1	0.1	-1.9	-1.1	0.0	-2.0
Medication: Ibuprofen	0.3	0.3	1.0	0.3	0.4	0.8	0.2	1.0	0.1
Medication: Allopurinol	1.1	1.4	5.8	2.4	-0.2	-0.2	0.1	-0.6	-1.5
Medication: Omeprazole	0.9	1.0	1.7	0.1	-1.2	1.3	1.1	1.1	-0.9
Medication: Seretide 50 evohaler	0.3	0.3	0.9	0.9	-0.3	0.4	-0.8	0.1	-0.5
Mean time to correctly identify matches	0.8	1.4	2.5	-1.0	1.1	1.6	1.3	0.2	1.5
Heart disease (mother)	1.6	1.9	4.8	0.2	-2.2	-1.3	-1.8	0.5	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	3.5	1.9	-0.8	1.1	1.2	1.2	-0.9
Whole body fat mass	0.3	1.5	2.6	0.4	-1.4	0.4	-1.4	-1.6	-1.5
Leg fat mass (right)	0.4	1.5	3.7	0.4	-0.8	-0.1	-1.2	-1.9	-1.8
Arm predicted mass (right)	1.0	5.0	15.4	0.9	3.9	-1.9	0.7	-3.1	0.2
Pulse rate, automated reading	0.3	1.0	3.5	-0.5	-1.2	0.8	-0.3	-1.9	-0.1
Alcohol intake frequency.	0.1	0.3	0.8	-0.9	0.6	0.3	0.7	0.4	-0.2
Comparative height size at age 10	0.3	1.7	5.1	1.2	1.1	-0.3	-0.4	-2.2	1.4
Number of full sisters	0.9	1.1	3.5	-0.1	-0.8	1.2	1.9	0.8	0.6
Suffer from ‘nerves’	0.7	1.1	3.1	1.3	0.7	0.7	1.8	-0.2	1.0
Overall health rating	1.2	2.7	6.8	-1.3	-2.5	0.6	-2.6	-0.9	-0.2
Chest pain or discomfort	0.6	0.8	1.7	0.6	-0.6	-0.8	-1.2	-0.6	-1.3
Had major operations	2.2	2.6	6.7	1.7	2.6	-0.5	2.0	-1.2	0.8
Age at last live birth	0.7	1.1	2.1	-0.5	1.0	-1.4	1.0	-1.0	-1.0
Family relationship satisfaction	0.3	0.3	0.9	-0.5	0.2	-1.0	0.4	-0.8	0.3
Leg pain on walking	0.7	0.9	2.4	1.5	-0.2	1.6	-0.6	0.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	-0.3	-1.0	-1.2	0.2	-0.2	-0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	3.5	-1.9	-0.2	0.5	-1.3	-0.0	-1.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	-0.4	-0.1	-0.8	0.5	1.6	0.9
Medication: Aspirin	0.9	1.2	5.6	-0.8	-0.7	-0.2	0.6	2.4	0.3
Supplements: Vitamin C	0.7	0.8	2.0	1.4	0.0	1.4	0.7	0.5	0.2
Knee pain experienced in last month	0.8	1.3	7.3	0.4	-0.2	2.7	-0.3	-0.5	0.1
Hypertension (Self-reported)	0.3	0.8	2.3	1.1	-0.5	-1.5	0.7	0.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	1.9	0.4	-0.6	1.4	-1.1	-0.6	-1.0
Illnesses of father: Heart disease	0.6	0.8	2.4	0.8	0.2	0.2	-1.1	0.5	-1.5
Illnesses of siblings: Diabetes	1.6	1.9	6.2	0.9	-1.2	1.2	2.5	0.5	1.2
Smoking status: Previous	0.8	1.2	2.6	0.8	-1.2	1.4	-0.4	1.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	5.4	2.3	1.5	-0.3	0.2	-1.8	-0.5
Whole body fat-free mass	1.0	5.6	17.3	1.3	4.2	-1.5	1.0	-3.3	0.2
Leg fat-free mass (right)	0.6	3.4	8.9	1.3	3.0	-1.4	0.7	-2.7	0.1
Arm fat percentage (left)	0.7	2.8	7.6	-0.3	-2.8	0.5	-1.6	-1.2	-2.3
Average weekly red wine intake	0.6	0.8	2.1	0.8	1.4	1.3	-0.1	-0.8	-0.2
Handedness (chirality/laterality): Left-handed	1.5	1.9	5.6	0.2	-0.3	0.3	-0.4	2.4	-2.3
Mood swings	0.1	0.2	0.7	-0.1	-0.6	-0.8	-0.3	-0.1	-0.4
Loneliness, isolation	0.4	0.6	1.0	-0.7	-0.4	1.0	0.6	-0.9	-0.9
Long-standing illness, disability or infirmity	0.2	0.3	0.9	0.3	0.6	0.9	0.5	0.2	0.2
Ever had bowel cancer screening	0.3	0.4	1.2	0.4	-0.5	0.6	-0.2	1.1	0.4
Diabetes diagnosed by doctor	0.4	0.6	2.6	-1.6	0.7	0.4	0.5	0.1	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	6.0	-2.4	-0.1	1.1	0.3	0.0	-0.1
Friendships satisfaction	0.7	0.9	2.1	-0.8	-0.0	-0.9	-0.6	1.2	1.5
Qualifications: nursing, teaching	0.9	1.3	4.9	0.8	0.6	1.1	0.5	2.2	-0.7
Commuting to job workplace: Walk	0.1	0.1	0.3	-0.0	-0.4	-0.3	0.3	0.5	0.6
Eye problems/disorders: Cataract	0.3	0.4	1.1	-0.2	0.1	-1.0	0.1	0.4	-1.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.7	2.2	0.1	-0.7	0.1	0.4	1.1
Medication for cholesterol	0.4	0.6	1.7	-1.3	0.0	-0.9	0.1	0.6	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	5.9	1.1	-0.5	2.4	-1.0	-1.1	-0.2
Back pain experienced in last month	0.8	1.1	2.5	-1.6	-0.2	1.2	-1.3	-1.0	-0.0
Mineral and other dietary supplements	0.4	0.5	1.9	-0.1	-0.6	-1.4	0.2	0.2	0.8
Breast cancer (self-reported)	1.2	1.4	4.2	-0.3	0.5	0.4	-2.1	-1.2	-1.4
Asthma (self-reported)	0.4	0.8	2.2	-1.5	0.1	-0.7	1.1	0.4	-0.7
Osteoporosis (self-reported)	0.7	0.9	1.9	0.3	-1.4	0.9	-1.2	0.8	0.5
Osteoarthritis (self-reported)	0.4	0.5	1.6	0.1	1.3	0.8	-0.1	-0.4	-0.8
Medication: Aspirin	0.6	0.8	3.6	0.2	-0.7	0.1	0.7	1.9	0.5
Medication: Gliclazide	0.5	0.6	1.6	-0.8	1.0	-0.1	1.3	-0.5	0.1
Illnesses of father: None of the above (group 1)	1.4	1.7	6.6	-0.3	1.1	-0.7	1.3	-0.6	2.6
Smoking status: Current	0.9	1.5	2.3	-1.1	-0.8	-1.5	-1.0	-1.2	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.5	-0.0	0.8	-1.3	-1.0	-1.9	1.2
Whole body water mass	1.0	5.5	17.1	1.4	4.1	-1.5	1.1	-3.3	0.2
Leg predicted mass (right)	0.7	3.5	9.3	1.4	3.0	-1.4	0.7	-2.8	-0.0
Arm fat mass (left)	0.3	1.4	3.6	0.2	-1.0	-0.2	-1.0	-1.9	-1.7
Number of self-reported non-cancer illnesses	0.3	0.6	2.0	0.5	-0.2	0.5	0.8	1.4	0.3
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.6	0.3	0.1	0.4	1.1	0.1
Miserableness	0.1	0.2	0.5	-0.2	0.1	0.6	0.3	0.5	-0.7
Guilty feelings	0.8	1.2	3.9	-0.9	2.0	0.2	1.0	1.2	-0.5
Wears glasses or contact lenses	0.4	0.4	1.3	0.2	1.1	-0.1	-0.5	0.7	0.7
Ever taken oral contraceptive pill	0.7	0.8	1.8	-1.3	-0.4	-0.4	-1.0	-1.3	-0.3
Hearing aid user	0.9	1.0	3.4	0.0	1.8	-0.1	0.9	0.7	1.2
Mother’s age at death	0.2	0.3	1.5	1.2	-0.1	-0.2	0.4	-0.2	-0.1
Financial situation satisfaction	0.8	1.0	4.5	0.4	0.1	2.1	-1.1	0.5	0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	1.1	0.3	-0.8	-1.0	-0.2	0.0	0.4
Commuting to job workplace: Public transport	0.2	0.3	1.0	0.5	0.1	-1.0	0.5	0.2	0.2
Eye problems/disorders: Glaucoma	0.9	1.0	3.0	0.6	1.4	-1.7	0.8	-0.6	0.4
Medication: Blood pressure	0.6	1.1	2.6	0.5	-1.2	-0.7	-1.2	-0.6	-1.6
Pain type(s) experienced in last month: Hip pain	1.0	1.2	5.1	0.4	1.4	2.3	-0.1	-0.3	0.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.6	0.3	-0.1	1.6	-0.8	-0.6	-1.1
High cholesterol (Self-reported)	0.8	1.4	3.8	-0.3	-0.1	-0.2	1.1	1.7	2.0
Medication: Bendroflumethiazide	0.5	0.7	2.4	-0.5	-0.1	-1.5	-0.0	0.9	0.9
Medication: Paracetamol	0.3	0.4	2.3	-0.0	-1.5	0.2	0.1	0.3	0.1
Medication: Lisinopril	0.7	0.9	1.7	0.0	-0.6	-1.3	1.1	0.9	-1.2
Medication: Atorvastatin	1.8	2.2	6.1	1.5	0.7	2.5	1.5	0.3	-1.4
Illnesses of father: High blood pressure	1.4	1.7	3.6	-1.7	-1.9	-0.1	-1.2	1.0	-1.2
Alcohol drinker status: Never	0.6	0.7	2.1	1.0	1.4	-1.0	0.4	0.3	-0.4
Ever smoked	0.8	1.5	3.8	0.4	-2.0	-0.1	-0.9	0.8	-1.8
Basal metabolic rate	0.8	4.2	11.2	1.3	3.3	-1.5	0.6	-3.2	0.1
Leg fat percentage (left)	0.6	2.0	3.9	-0.7	-2.0	0.7	-1.8	-0.6	-1.9
Arm fat-free mass (left)	0.9	4.5	13.2	1.0	3.6	-1.6	0.5	-3.1	-0.3
Number of operations (self-reported)	1.2	1.8	6.8	0.1	2.6	0.7	1.4	0.8	-0.8
Average weekly beer plus cider intake	1.5	2.2	4.3	-1.8	0.9	-2.1	0.3	1.5	1.6
Irritability	0.2	0.4	0.6	-0.8	-0.7	-0.2	-0.2	0.8	-0.7
Risk taking	1.2	1.8	3.0	1.3	-0.8	1.6	-1.7	-1.7	-0.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.6	0.5	0.1	-0.6	1.0	1.4	1.6
Fractured/broken bones in last 5 years	0.6	0.8	2.1	0.5	1.4	1.4	-0.2	0.6	0.1
Age started oral contraceptive pill	0.1	0.2	0.8	0.9	-0.2	0.6	-0.1	-0.1	-0.0
Diastolic blood pressure, automated reading	0.2	0.8	2.2	-0.0	-1.3	0.4	0.2	-0.5	-1.5
Ever depressed for a whole week	0.6	0.7	3.0	-1.7	0.5	-1.0	0.1	0.1	0.1
Unable to work because of sickness or disability	0.3	0.4	1.3	0.2	1.0	1.1	0.1	-0.0	0.6
Commuting to job workplace: Cycle	1.6	1.9	5.2	1.2	1.7	2.3	0.3	0.3	1.4
Myopia	1.0	1.4	2.9	0.8	-0.7	1.0	-1.0	1.6	1.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	-1.0	1.1	1.1	0.0	0.2	0.3
Cholesterol lowering medication	0.8	1.2	4.6	1.2	0.5	2.1	0.2	-0.7	-0.5
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.2	0.3	-0.3	1.6	1.0	0.8	-1.8
Pain experienced in last month	0.5	0.9	4.2	-0.2	-0.1	-2.0	1.0	0.3	-0.0
Supplements: Calcium	0.5	0.6	1.9	0.5	-0.6	-0.4	0.7	0.5	1.4
Basal cell carcinoma (self-reported)	1.3	1.6	6.5	2.6	-1.5	-0.6	-0.2	0.2	-0.5
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.5	0.7	0.5	1.2	-0.6	-1.2	-1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.0	1.4	-1.3	0.4	1.7	0.6	0.2
Heart disease (siblings)	0.3	0.4	1.0	-0.1	-1.0	0.5	0.1	-0.3	-0.9
Alcohol drinker status: Previous	0.6	0.7	2.1	-0.7	0.5	0.7	-0.7	1.5	0.7
Pack years of smoking	0.3	0.5	1.0	-0.7	-1.0	-0.8	0.9	-0.3	-0.1
Impedance of whole body	1.3	6.7	24.0	0.1	-4.9	1.9	-2.8	2.1	0.5
Leg fat mass (left)	0.3	1.3	2.9	0.2	-0.5	-0.2	-1.3	-1.7	-1.7
Arm predicted mass (left)	0.9	4.4	13.8	1.2	3.7	-1.5	0.5	-3.0	-0.1