Hub : Genes

RINL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1050 0.0310 2.9e-05 0.069 0.056 0.072 0.063 0.075 9.1e-09 2.0e-07 3.7e-09 3.4e-08 2.1e-09
2 GTEx Artery Aorta 0.1780 0.0530 3.2e-04 0.089 NA 0.110 NA 0.112 1.3e-05 NA 1.2e-06 NA 1.0e-06
3 GTEx Esophagus Mucosa 0.2400 0.0620 1.5e-05 0.117 NA 0.126 NA 0.128 3.1e-08 NA 8.9e-09 NA 6.8e-09
4 GTEx Skin Sun Exposed Lower leg 0.1000 0.0410 7.3e-03 -0.002 NA -0.003 NA 0.001 4.9e-01 NA 9.9e-01 NA 2.8e-01
5 GTEx Spleen 0.2970 0.1090 6.2e-03 0.156 NA 0.064 NA 0.085 8.2e-05 NA 1.0e-02 NA 3.3e-03
6 YFS Blood 0.0362 0.0105 1.1e-07 0.036 0.022 0.033 0.028 0.040 5.2e-12 5.9e-08 3.9e-11 1.4e-09 3.4e-13
7 TCGA Kidney Renal Clear Cell Carcinoma 0.0667 0.0349 2.1e-04 0.013 0.038 0.042 NA 0.021 1.1e-02 3.4e-05 1.5e-05 NA 1.9e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.9 2.8 -0.9 1.1 0.2 -0.8 0.3 0.7 1.7
Bipolar Disorder or Schizophrenia 0.8 1.9 7.9 -0.8 0.9 1.2 -2.8 0.8 0.3 1.2
Depressed Affect (Nagel 2018) 1.9 4.0 6.4 2.3 -2.5 2.2 -1.7 0.4 -2.5 -1.3
Depression (Nagel 2018) 2.2 3.3 5.7 2.2 -2.3 1.4 -1.6 0.3 -2.4 -1.6
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.3 1.5 -1.4 1.1 0.2 0.1 -1.2 -1.0
Neuroticism (Nagel 2018) 0.5 1.3 2.3 1.1 -1.2 1.5 -1.5 0.3 -1.1 -0.7
Schizophrenia (2018) 0.8 1.7 8.9 -0.3 0.1 1.5 -3.0 0.8 -0.5 0.3
Schizophrenia vs Biploar Disorder 1.8 2.3 7.0 1.2 -1.2 2.6 -0.5 0.7 -1.8 -1.6
Worry (Nagel 2018) 0.2 0.5 1.4 -0.8 1.2 -0.5 -0.2 -0.2 0.8 0.7
Alzheimer’s Disease (in mother) 0.8 1.0 4.5 0.0 -0.3 -0.3 2.1 1.2 0.6 -0.7
Alzheimer’s Disease (in father) 0.8 0.9 3.3 -0.8 1.1 -0.4 -0.8 1.8 -0.2 0.7
Alzheimer’s Disease (including proxy) 1.0 1.4 3.5 0.9 -1.0 0.0 1.7 1.9 -0.2 -1.3
Crohns Disease (2017) 1.2 2.5 3.9 -2.0 2.0 -1.4 0.8 1.2 1.5 1.9
Irritable Bowel Disease (IBD) 1.1 2.6 3.7 -1.6 1.7 -1.9 0.5 1.8 1.5 1.9
Ulcerative Colitis (UC) 0.4 0.7 2.2 -0.1 0.3 -1.5 -0.3 1.3 0.5 0.8
Major Depression (MDD) 0.5 0.6 1.4 0.6 -0.7 0.3 1.1 -1.2 0.0 -0.8
Reaction Time 2.1 4.1 8.1 2.8 -2.7 0.6 1.5 0.6 -1.6 -2.8
Verbal and Numeric Reasoning (VNR) 0.7 1.8 3.6 1.9 -1.9 0.8 -0.2 0.6 -1.4 -1.6
Breast Cancer 0.3 0.7 2.5 0.1 -0.1 -0.8 1.6 0.4 -0.2 -1.3
Ovarian Cancer 0.5 0.7 1.2 -0.8 0.8 -1.0 -0.9 1.1 0.4 0.2
Prostate Cancer 0.6 0.9 4.2 0.6 -1.0 0.1 -2.1 0.1 -0.8 0.0
Age at First Birth 0.5 0.8 2.0 -0.8 1.1 -1.4 0.8 -0.1 0.9 0.6
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.3 1.8 3.2 -1.6 1.8 -0.9 -1.7 0.4 1.0 1.6
Coronary Artery Disease (CAD) 0.8 1.0 4.1 0.4 0.0 0.3 2.0 1.6 0.0 0.0
Crohns Disease (2012) 1.3 2.1 3.4 -1.8 1.8 -1.3 1.1 0.3 1.7 1.4
Mean Putamen Volume 0.1 0.1 0.5 -0.1 0.1 -0.2 -0.2 0.5 0.2 -0.7
Fasting Glucose 0.4 0.5 1.0 0.5 -0.4 -0.8 -0.6 -0.7 -1.0 0.7
HbA1C 0.3 0.3 0.7 0.5 -0.2 -0.8 -0.5 -0.6 -0.7 0.5
HDL Cholesterol 0.5 0.8 2.4 0.6 -0.4 -0.1 1.6 0.5 -0.4 -1.4
LDL Cholesterol 0.4 0.6 1.3 0.7 -0.8 1.1 -0.3 -0.6 -0.7 -0.7
Lupus 1.1 1.7 3.5 1.9 -1.7 0.5 -0.1 1.3 -1.6 -0.8
Neuroticism (2016) 0.2 0.4 1.1 -0.3 0.6 0.0 -0.9 -0.3 0.1 1.0
Primary Biliary Cirrhosis 0.9 1.3 2.5 -1.3 1.6 -1.1 -0.2 0.9 0.9 1.3
Rheumatoid Arthritis 1.6 2.3 4.6 -1.5 1.4 -2.0 -0.6 1.1 2.1 1.2
Schizophrenia (2014) 0.7 1.4 5.1 -0.3 0.2 2.2 -2.3 0.0 -0.4 -0.0
Triglycerides 0.5 0.9 1.4 -1.1 1.0 -0.9 0.6 0.4 1.2 1.0
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.5 -0.2 0.0 -0.1 -0.7 0.3 0.0 0.0
Ulcerative Colitis 0.4 0.6 1.9 0.2 -0.1 -0.8 -1.1 1.4 -0.4 0.3
Blood Eosinophil Count 0.9 6.6 12.7 -3.5 3.6 -2.9 -0.5 -0.6 2.6 2.4
Blood Platelet Count 2.0 23.4 45.0 -6.7 6.6 -4.3 -0.4 -0.4 6.3 4.1
Blood Red Count 0.3 3.2 8.9 -2.0 2.0 -3.0 1.5 0.9 1.5 0.5
Blood White Count 0.9 6.6 12.7 -3.1 2.9 -3.6 -0.4 -1.0 3.2 2.0
Heel T-Score 0.1 1.1 3.3 -0.4 0.7 -1.8 -0.7 1.6 -0.4 0.8
BMI 0.1 0.9 2.1 0.4 -0.6 1.4 -0.5 0.9 -1.2 -1.0
Height 0.3 6.3 21.7 0.5 0.5 -0.2 3.4 4.7 -2.4 2.0
Waist Hip Ratio (WHR) 1.1 5.1 8.5 -2.9 2.9 -2.5 -1.1 1.4 1.8 2.4
Systolic Blood Pressure 0.7 3.7 9.4 -2.0 2.1 -3.1 -1.1 -0.5 2.1 1.2
Smoking Status 0.7 1.6 4.3 1.0 -1.2 1.5 2.1 0.7 -0.3 -1.3
Allergy or Eczema 0.8 2.0 5.6 -1.0 0.8 -2.4 1.4 -0.9 1.9 0.8
Cardiovascular Disease 0.1 0.4 0.8 0.5 -0.4 0.7 -0.7 0.5 -0.8 -0.9
Hypothyroidism (self reported) 0.2 0.4 1.5 0.4 -0.1 -0.0 0.9 1.2 -0.3 -0.2
Respiratory disease 0.1 0.3 1.2 0.1 0.1 0.7 0.7 -1.1 0.2 -0.1
Type 2 Diabetes (T2D) (2018) 0.0 0.0 0.2 0.1 -0.4 0.0 -0.1 0.0 -0.0 -0.2
Lung FEV1/FVC ratio 0.1 0.7 1.6 -0.7 0.5 0.5 1.3 -1.0 1.0 -0.4
Lung FVC 0.1 0.5 1.7 0.5 -0.3 0.0 -0.9 -1.3 -0.6 -0.7
Neuroticism 0.4 0.9 2.8 0.5 -0.6 1.7 -1.1 0.5 -1.1 -0.4
Chronotype (morning person) 0.2 0.5 2.5 -0.4 0.3 -1.6 0.5 -0.8 0.5 -0.1
Hair Pigment 0.0 0.5 0.8 -0.8 0.8 0.6 -0.9 -0.8 0.6 0.6
Tanning 0.2 3.0 6.5 2.4 -2.5 1.5 -0.9 0.2 -2.1 -1.0
Hand grip strength (left) 0.2 0.6 1.9 0.5 -0.2 -0.3 -0.7 1.4 -1.2 0.2
Number of treatments/medications taken 0.5 1.0 4.7 -0.7 0.8 -0.9 0.2 2.2 -0.1 0.2
Average weekly spirits intake 0.3 0.4 1.0 -0.5 1.0 0.1 0.4 0.7 0.1 0.7
Sensitivity / hurt feelings 0.5 0.8 2.3 -0.7 0.5 -0.5 -1.5 -0.2 1.1 1.1
Frequency of depressed mood in last 2 weeks 1.5 2.1 4.5 1.6 -1.7 0.3 -2.1 -0.3 -1.7 -1.4
Hearing difficulty/problems: Yes 0.1 0.2 0.7 0.4 -0.3 0.8 -0.4 -0.2 -0.2 -0.2
Relative age of first facial hair 0.4 0.9 2.4 -1.2 1.0 -0.1 0.3 0.9 1.6 0.8
Other serious medical condition/disability diagnosed by doctor 0.0 0.1 0.2 0.2 -0.2 -0.5 0.0 -0.1 -0.1 0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.8 2.2 -0.2 0.4 -1.5 1.1 1.0 0.4 0.9
Ever had hysterectomy (womb removed) 1.2 1.3 4.7 0.8 -0.7 0.8 2.2 -0.3 -0.1 -1.6
Systolic blood pressure, automated reading 0.6 1.9 4.3 -1.7 1.8 -2.1 -0.2 0.1 1.3 1.0
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.4 0.3 -0.2 0.4 -0.1 0.3 0.4 -0.6
Angina 1.6 2.1 3.6 -1.7 1.9 -0.8 -0.4 -1.7 1.3 1.6
Medication for hormone replacement therapy 0.8 0.9 2.2 -1.4 1.5 -0.4 -0.9 -0.0 0.7 0.7
Vitamin and mineral supplements 0.9 1.2 3.6 -1.7 1.9 0.1 0.2 0.2 0.5 1.2
Supplements: Zinc 0.1 0.1 0.2 -0.0 0.0 0.4 -0.0 0.4 -0.5 -0.4
Medication: Co-codamol 0.8 0.9 1.5 -1.2 1.2 -0.5 0.6 1.2 1.2 0.3
Medication: Metformin 0.7 1.0 2.1 1.1 -1.2 0.2 1.4 0.7 -1.2 -0.5
Diabetes (father) 2.1 2.6 7.1 -1.3 1.9 -1.4 -0.8 1.4 1.1 2.7
Diabetes (mother) 0.4 0.5 1.7 -0.4 0.6 -0.5 0.9 0.4 0.1 1.3
Severe depression (siblings) 0.2 0.3 0.6 -0.5 0.7 0.1 -0.8 -0.1 0.1 0.7
Pack years adult smoking proportion 0.6 0.9 2.8 -0.9 1.0 0.6 0.4 1.7 0.5 0.9
Impedance of leg (right) 0.2 1.0 3.0 -1.1 1.3 -0.5 0.5 -0.6 0.4 1.7
Leg fat-free mass (left) 0.1 0.5 1.4 0.6 -0.5 0.1 0.3 1.0 -1.2 -0.4
Trunk fat percentage 0.2 0.7 2.2 -1.5 1.4 0.4 0.1 0.3 0.2 0.6
Hand grip strength (right) 0.1 0.3 1.0 0.5 -0.0 -0.7 0.6 0.2 -1.0 0.4
Townsend deprivation index at recruitment 1.0 1.4 3.6 0.8 -0.6 -0.1 -1.3 -1.9 -0.8 -1.8
Current tobacco smoking 1.1 1.8 6.9 -1.4 1.2 0.8 2.6 0.6 1.1 0.3
Average weekly fortified wine intake 0.3 0.4 0.8 -0.9 0.6 -0.8 -0.2 -0.6 0.7 0.5
Maternal smoking around birth 0.7 1.1 2.6 -1.1 1.1 0.1 -1.6 0.4 -0.2 1.6
Fed-up feelings 0.5 1.0 2.4 0.9 -0.6 1.2 -1.0 0.7 -1.6 -0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.9 0.6 -0.7 1.1 -1.7 0.1 -1.0 -0.4
Relative age voice broke 0.9 1.4 3.8 -1.4 1.1 -0.7 0.3 1.4 1.9 0.7
Taking other prescription medications 0.3 0.4 2.4 0.3 -0.4 -0.5 1.6 -0.0 0.1 0.2
Age when periods started (menarche) 1.1 2.7 8.5 0.8 -1.0 1.9 1.9 -0.4 -1.0 -2.9
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 3.3 0.9 -0.8 -0.4 1.8 0.9 -1.0 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 4.3 0.3 -0.0 -0.8 0.2 2.1 -0.3 -0.3
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.5 0.3 -0.3 -0.7 0.0 -0.5 0.3 -0.2
Qualifications: CSEs or equivalent 1.5 2.0 3.5 -1.5 1.3 -1.6 -0.8 -0.5 1.9 1.8
Serious illness, injury or assault to yourself 0.3 0.3 1.1 -0.6 0.3 -0.6 0.4 -0.1 1.1 0.3
High blood pressure 0.1 0.4 0.9 -0.1 0.4 -1.0 0.9 0.2 0.3 -0.8
Hayfever, allergic rhinitis or eczema 0.9 2.0 5.7 -1.1 1.1 -2.4 1.4 -0.7 1.6 0.7
Multivitamins +/- minerals 0.5 0.6 1.8 0.9 -1.2 0.2 0.2 -0.3 0.2 -1.3
Stomach or abdominal pain in last month 1.0 1.3 1.9 -1.0 0.9 -1.4 -0.2 1.3 1.4 1.2
Supplements: Glucosamine 0.9 1.2 2.1 -0.8 0.8 -1.5 -1.4 0.4 0.9 1.3
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 2.3 0.1 -0.2 -0.4 1.5 -0.9 0.4 0.5
Medication: Atenolol 0.1 0.1 0.2 -0.1 -0.4 0.5 -0.4 0.2 0.1 -0.3
Medication: Levothyroxine sodium 1.6 2.8 3.7 -1.9 1.6 -1.6 1.9 1.6 1.7 1.3
Sitting height 0.4 2.7 8.1 1.5 -1.1 0.5 2.9 1.6 -2.2 -0.5
Chronic bronchitis/emphysema (father) 1.5 1.8 3.2 1.3 -1.1 1.3 1.2 1.8 -1.8 -0.0
High blood pressure (mother) 0.4 0.5 1.4 0.3 -0.3 0.9 0.1 -0.8 -0.8 -1.2
Body mass index (BMI) 0.1 0.2 0.6 -0.3 0.0 0.8 -0.5 0.7 -0.2 -0.4
Impedance of leg (left) 0.2 1.2 3.0 -1.3 1.5 -0.4 0.2 -0.6 0.7 1.7
Leg predicted mass (left) 0.1 0.5 1.5 0.7 -0.5 0.2 0.2 1.1 -1.2 -0.3
Trunk fat mass 0.1 0.5 1.1 -1.1 1.0 0.6 0.3 0.8 -0.3 0.5
Waist circumference 0.2 0.6 1.5 -1.2 1.0 0.0 0.0 1.1 0.1 0.4
Number of incorrect matches in round 0.4 0.7 2.6 0.7 -0.9 -1.0 1.6 -0.2 -0.2 0.1
Past tobacco smoking 1.1 2.0 5.7 -1.2 1.3 -1.5 -1.5 0.4 0.7 2.4
Alcohol usually taken with meals 0.4 0.6 2.9 0.1 -0.4 -1.1 -1.7 0.1 0.1 -0.0
Nervous feelings 0.2 0.3 1.0 -0.4 0.7 -1.0 0.2 0.0 0.7 -0.5
Frequency of tenseness / restlessness in last 2 weeks 1.5 2.3 5.4 1.4 -1.4 0.9 -2.3 -0.6 -1.6 -1.7
Hearing difficulty/problems with background noise 0.2 0.4 0.7 0.9 -0.8 0.3 0.5 0.7 -0.6 -0.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.7 -0.1 -0.0 0.5 0.6 0.4 0.7 -0.8
Had menopause 0.3 0.3 0.7 0.7 -0.5 0.1 0.6 0.7 -0.8 0.1
Had other major operations 0.6 0.7 2.1 0.7 -1.0 0.8 -0.1 -1.4 -0.3 -0.9
Forced vital capacity (FVC) 0.2 0.8 3.1 1.1 -0.7 -0.1 0.0 0.5 -1.8 -0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 4.5 0.3 -0.0 -0.8 -0.8 2.1 -1.0 0.1
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.7 -0.9 1.0 1.0 0.8 -1.6 -0.4 0.3
Qualifications: None of the above 0.1 0.3 0.6 -0.6 0.7 -0.6 -0.4 -0.8 0.2 0.2
Financial difficulties in last 2 years 0.3 0.4 1.7 -0.4 0.0 -0.8 0.4 1.3 0.6 0.0
Mouth/teeth dental problems 0.8 1.2 3.9 -1.2 1.3 0.0 -0.5 0.9 0.7 2.0
Heart attack 0.4 0.6 2.1 0.2 0.1 0.8 0.9 -0.2 -1.4 -0.5
Allergy 0.2 0.5 1.4 0.2 -0.0 1.1 -0.3 1.2 -0.9 -0.1
Pain all over the body in last month 2.6 2.8 3.7 1.9 -1.9 1.5 0.5 1.9 -1.8 -1.8
Diabetes (self-reported) 0.1 0.1 0.3 0.4 -0.6 -0.0 -0.2 0.4 -0.1 0.1
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.4 -1.1 0.8 -1.6 0.4 1.2 1.0 0.8
Medication: Ramipril 1.5 2.0 3.9 -2.0 1.8 -1.3 1.0 1.3 1.0 1.0
Medication: Simvastatin 0.5 0.8 1.3 -1.0 0.8 -0.5 -0.4 1.1 1.0 1.1
Fluid intelligence score 0.2 0.4 1.3 0.7 -0.7 0.0 -0.2 1.1 0.2 -0.6
Illnesses of siblings 0.4 0.6 3.5 0.4 -0.4 -0.2 -0.2 1.9 -0.0 0.5
Neuroticism score 0.1 0.1 0.2 -0.4 0.4 0.0 -0.4 0.3 0.1 0.2
Weight 0.1 0.5 2.3 -0.2 0.2 0.4 0.4 1.5 -0.7 0.3
Impedance of arm (right) 0.4 2.0 3.7 -1.5 1.5 -1.5 0.7 -1.9 1.6 0.6
Arm fat percentage (right) 0.1 0.3 1.2 -1.1 0.7 0.4 -0.2 -0.1 0.5 -0.1
Trunk fat-free mass 0.2 1.2 4.5 0.7 -0.4 0.0 0.6 2.1 -1.6 0.4
Hip circumference 0.1 0.6 2.1 0.1 -0.1 1.4 0.2 0.9 -1.1 -0.4
Time employed in main current job 0.8 0.9 2.4 0.9 -1.1 1.6 0.3 0.8 -0.6 -0.9
Alcohol intake versus 10 years previously 0.2 0.3 0.8 -0.2 -0.1 -0.9 -0.5 -0.8 0.4 -0.3
Father’s age at death 0.8 1.0 5.8 -0.3 0.6 0.5 0.0 2.4 -0.3 0.8
Worrier / anxious feelings 0.5 1.0 2.5 -1.1 1.6 -0.7 0.3 1.2 0.4 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.7 1.3 1.1 -1.1 0.4 -0.9 0.5 -0.9 -0.8
Falls in the last year 1.5 2.0 5.2 1.5 -1.8 1.4 1.0 0.3 -0.7 -2.3
Hair/balding pattern: Pattern 3 0.5 0.8 2.1 -0.8 0.4 -0.6 -0.1 1.1 1.1 1.4
Number of live births 0.1 0.1 0.2 -0.2 0.0 0.5 0.4 -0.3 0.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.1 0.4 1.0 0.8 -0.5 -0.4 0.1 -0.1 -1.0 -0.9
Pulse rate 0.5 0.9 3.8 0.3 -0.2 1.1 1.9 -0.8 0.3 -0.6
Happiness 1.4 1.7 4.6 -1.2 1.1 -0.5 1.1 2.1 0.8 1.5
Noisy workplace 0.3 0.3 0.6 0.3 -0.4 0.6 0.6 -0.7 0.5 -0.8
Qualifications: A levels/AS levels or equivalent 0.6 1.2 2.5 -1.3 1.4 -1.0 -1.6 -0.8 0.6 0.9
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 2.9 0.0 0.3 -0.5 -0.1 -1.7 -0.4 -0.0
Mouth/teeth dental problems: Dentures 0.9 1.5 3.8 -1.2 1.1 -1.7 -0.1 -0.2 2.0 1.1
Asthma 0.4 0.8 4.4 0.6 -0.6 0.2 -0.7 -2.1 -0.1 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.8 0.3 -0.2 1.1 1.1 -1.3 -1.3 -0.7
Medication: Cholesterol lowering 0.8 1.2 2.9 -1.3 1.4 -0.5 -0.7 1.2 0.3 1.7
Depression (self-reported) 0.3 0.4 2.4 -0.0 -0.1 1.6 -0.1 -0.4 -0.2 -0.4
Medication: Lansoprazole 0.2 0.2 0.6 0.2 -0.2 -0.2 -0.5 0.5 -0.7 0.7
Prospective memory result 0.9 1.1 2.9 -0.2 0.3 -1.6 -0.5 -1.2 0.7 1.7
Lung cancer (father) 1.3 1.6 2.1 1.2 -1.5 1.3 -1.4 0.6 -1.0 -1.4
Illnesses of mother 0.3 0.4 1.2 -0.3 0.1 -0.6 -0.5 -0.5 1.1 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 1.7 0.9 -0.7 -1.0 0.0 -0.4 -1.0 -1.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.3 -0.9 1.1 -0.4 -0.4 -0.9 0.3 0.5
Impedance of arm (left) 0.3 1.3 3.3 -1.3 1.3 -0.5 0.9 -1.8 0.8 0.8
Arm fat mass (right) 0.0 0.2 0.4 -0.6 0.4 0.4 0.2 0.6 -0.2 0.1
Trunk predicted mass 0.2 1.2 4.3 0.7 -0.5 -0.0 0.6 2.1 -1.6 0.4
Standing height 0.2 2.0 4.6 0.1 0.5 -0.9 2.1 2.0 -1.5 1.5
Length of working week for main job 0.8 0.9 2.4 0.9 -1.2 1.0 0.2 0.5 -0.4 -1.5
Exposure to tobacco smoke at home 1.6 1.8 3.1 1.7 -1.7 1.8 0.8 -0.8 -0.9 -1.3
Breastfed as a baby 0.1 0.2 0.3 -0.3 0.3 0.2 0.5 0.5 0.4 -0.5
Tense / ‘highly strung’ 0.1 0.1 0.3 0.4 -0.4 -0.3 0.3 -0.2 -0.4 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.4 -0.1 0.1 0.4 -0.5 0.7 -0.3 -0.5
Hair/balding pattern: Pattern 4 1.4 3.4 6.6 2.2 -2.2 2.6 1.4 -0.6 -2.0 -1.1
Birth weight of first child 0.3 0.6 1.8 1.3 -0.9 -0.3 -0.9 -0.4 -0.8 0.1
Peak expiratory flow (PEF) 0.2 0.4 1.4 0.4 -0.2 -0.5 -0.0 -0.8 -0.3 -1.2
Pulse wave reflection index 0.3 0.3 1.0 -0.5 0.4 -0.8 -1.0 -0.3 0.2 0.5
Ever highly irritable/argumentative for 2 days 1.6 1.9 3.0 1.6 -1.7 0.9 1.1 -0.5 -1.6 -1.7
Loud music exposure frequency 0.9 1.0 2.1 1.4 -1.5 1.2 1.1 0.4 -0.7 0.0
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 5.4 -1.1 1.3 -0.9 -2.3 -0.2 0.1 1.2
Mouth/teeth dental problems: Bleeding gums 3.3 4.3 10.7 2.0 -1.9 1.0 0.6 -2.6 -2.0 -3.3
Blood clot in the leg (DVT) 0.6 0.7 2.1 0.9 -0.5 1.5 -0.5 0.2 -1.1 -0.7
Medication: Paracetamol 0.0 0.0 0.2 -0.2 0.1 -0.2 0.1 -0.4 -0.2 0.1
Headache pain in last month 1.0 1.7 3.3 1.3 -1.4 0.1 1.6 1.2 -1.2 -1.8
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.6 0.8 -1.1 0.8 0.6 -1.3 -0.1 -1.2
Glaucoma (self-reported) 0.3 0.4 0.8 -0.6 0.2 -0.9 -0.2 0.3 0.9 0.8
Gout (self-reported) 0.3 0.4 2.2 0.2 0.3 -0.5 0.2 1.5 -0.4 0.3
Hypothyroidism/myxoedema (self-reported) 0.2 0.5 1.6 -0.0 0.0 -0.7 0.8 1.3 0.4 -0.6
Medication: Amlodipine 1.5 2.1 4.2 -1.8 1.7 -1.2 -0.5 2.1 1.7 0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.7 -0.1 0.2 0.1 -0.8 0.1 0.2 -0.5
Birth weight 1.6 3.5 5.8 -2.1 2.1 -0.9 -2.0 0.3 2.2 2.4
Chronic bronchitis/emphysema (mother) 1.2 1.4 3.5 0.8 -0.5 0.8 1.9 -0.8 -1.4 -1.6
High blood pressure (siblings) 0.8 1.2 5.9 0.2 -0.3 0.5 0.4 -2.4 -0.6 -1.3
Forced vital capacity (FVC), Best measure 0.4 1.4 3.8 1.6 -1.2 -0.4 0.3 0.1 -1.9 -1.3
Body fat percentage 0.1 0.4 1.3 -1.1 1.0 0.7 -0.1 0.3 -0.0 0.3
Leg fat percentage (right) 0.2 0.8 1.5 -1.2 1.1 0.6 -0.7 1.1 0.1 0.9
Arm fat-free mass (right) 0.3 1.4 4.0 0.8 -0.5 0.8 0.1 2.0 -2.0 0.4
Exposure to tobacco smoke outside home 1.0 1.3 5.7 0.7 -0.9 2.4 -1.3 0.2 -0.5 -0.6
Comparative body size at age 10 0.1 0.3 1.3 0.5 -0.1 -1.1 -0.0 0.5 -0.0 -0.3
Number of full brothers 1.2 1.6 8.6 0.5 -0.8 0.5 0.3 -2.9 -0.1 -1.0
Worry too long after embarrassment 0.4 0.7 1.8 -0.3 0.3 -1.2 -0.9 0.8 0.6 1.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 3.5 1.6 -1.9 1.6 0.5 -0.5 -1.7 -1.9
Wheeze or whistling in the chest in last year 0.1 0.2 0.6 0.1 -0.3 0.2 0.7 0.5 0.2 -0.8
Number of children fathered 0.2 0.2 0.9 -0.3 0.2 -0.4 0.9 0.5 0.4 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.6 0.7 1.4 1.2 -1.1 0.8 -0.4 0.3 -0.7 -1.0
Age at first live birth 0.3 0.5 1.1 0.5 -0.6 -0.6 0.9 -1.0 -0.6 -0.5
Pulse wave peak to peak time 0.4 0.4 1.0 0.8 -1.0 0.2 0.4 0.9 -0.4 -0.4
Health satisfaction 0.3 0.4 1.2 0.3 -0.6 1.1 1.0 -0.6 0.0 -0.1
Shortness of breath walking on level ground 1.3 1.5 4.6 1.0 -1.1 2.1 -0.7 -1.3 -0.7 -1.0
Qualifications: College or University degree 0.5 1.5 2.3 1.4 -1.3 1.2 0.9 1.5 -0.9 -1.4
Eye problems/disorders: None of the above 0.1 0.1 0.3 0.2 -0.1 -0.5 0.6 0.0 0.2 -0.2
Mouth/teeth dental problems: Loose teeth 2.4 2.8 5.8 2.4 -2.4 1.2 1.5 0.2 -0.9 -2.0
Emphysema/chronic bronchitis 0.4 0.4 1.8 -0.3 0.5 0.2 0.5 1.3 -0.3 0.8
Medication for pain relief, constipation, heartburn 0.3 0.4 1.7 -0.4 0.3 -0.9 -0.1 -0.4 1.3 0.5
Neck or shoulder pain in last month 0.3 0.5 2.6 -0.4 0.5 -0.3 0.0 -1.6 0.3 0.5
Medication: Blood pressure 0.5 0.9 2.1 -1.1 1.2 -0.7 0.0 1.4 0.6 0.8
Angina (self-reported) 1.2 1.5 3.0 -1.3 1.5 -0.6 -0.3 -1.7 0.9 1.5
Migraine (self-reported) 0.7 0.9 5.1 0.6 -0.4 0.7 0.0 -0.0 -2.3 -0.1
Medication: Ibuprofen 0.4 0.5 1.2 0.4 -0.3 0.8 0.8 -0.7 -1.1 -0.4
Medication: Allopurinol 0.4 0.5 2.0 0.6 -0.2 -0.1 1.4 0.8 -0.5 -0.1
Medication: Omeprazole 0.9 1.1 6.1 -0.6 0.7 -0.5 -0.0 2.5 0.5 0.3
Medication: Seretide 50 evohaler 2.4 2.8 5.1 -2.3 2.2 -1.2 1.1 1.0 1.5 1.9
Mean time to correctly identify matches 1.9 3.6 7.7 2.8 -2.5 -0.2 1.1 1.2 -1.9 -2.3
Heart disease (mother) 0.4 0.5 1.1 0.9 -0.4 -0.2 -0.9 0.8 -1.1 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.8 -0.8 0.7 0.2 -0.6 0.4 0.9 0.5
Whole body fat mass 0.1 0.3 0.6 -0.7 0.6 0.6 0.1 0.8 -0.6 0.3
Leg fat mass (right) 0.1 0.4 0.9 -0.6 0.5 0.7 0.1 1.0 -0.4 0.5
Arm predicted mass (right) 0.2 1.2 4.0 0.5 -0.3 0.6 0.2 2.0 -1.8 0.6
Pulse rate, automated reading 0.3 1.0 2.2 -0.8 1.0 0.6 1.5 -1.3 0.8 0.3
Alcohol intake frequency. 0.3 0.7 3.5 -0.2 -0.1 -0.2 0.2 -1.9 1.0 -0.4
Comparative height size at age 10 0.5 2.9 13.2 -1.0 1.6 -1.2 0.3 1.4 -0.5 3.6
Number of full sisters 0.3 0.4 1.3 0.1 -0.6 0.3 -0.4 -1.1 0.8 -0.5
Suffer from ‘nerves’ 0.4 0.6 2.1 -0.5 0.7 -0.8 -1.4 -0.7 0.5 0.5
Overall health rating 1.3 2.7 6.5 1.6 -1.8 2.1 0.1 -1.0 -1.1 -2.5
Chest pain or discomfort 0.9 1.4 7.1 0.5 -0.5 0.3 -2.7 1.1 -0.7 -0.2
Had major operations 0.5 0.6 2.2 -0.8 0.6 0.4 1.5 0.9 0.5 0.0
Age at last live birth 1.2 1.8 4.0 1.9 -2.0 0.5 -0.4 -0.7 -1.3 -1.5
Family relationship satisfaction 0.6 0.7 2.9 0.4 -0.5 0.3 1.7 -0.8 -0.7 -0.7
Leg pain on walking 1.2 1.5 2.3 1.5 -1.5 1.1 -0.8 -1.5 -0.9 -0.9
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.5 -0.8 0.6 -0.4 1.2 0.2 0.5 -0.0
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.5 0.2 -0.4 1.6 -0.7 0.1 -1.2 -0.7
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.8 -0.5 0.4 -0.1 -0.1 0.9 0.6 0.1
Medication: Aspirin 0.3 0.4 1.5 0.3 -0.1 0.4 -1.2 -0.2 -0.8 0.4
Supplements: Vitamin C 0.2 0.2 0.6 0.7 -0.5 -0.6 -0.2 -0.0 -0.7 -0.1
Knee pain experienced in last month 0.2 0.3 0.9 0.2 -0.2 1.0 0.0 0.4 -0.7 -0.4
Hypertension (Self-reported) 0.2 0.5 2.6 -0.0 0.2 -1.6 0.7 0.6 0.4 -0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.2 -0.1 0.1 0.1 -0.6 1.1 0.3 -0.5
Illnesses of father: Heart disease 0.7 0.9 2.0 1.0 -0.7 0.8 -1.4 0.9 -1.3 -0.2
Illnesses of siblings: Diabetes 0.5 0.6 2.1 0.6 -0.4 -1.5 -0.8 0.4 -0.6 0.5
Smoking status: Previous 1.1 1.6 4.8 1.4 -1.5 0.9 0.7 -0.6 -0.5 -2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.7 2.5 1.2 -0.7 0.2 0.4 0.2 -1.6 -0.6
Whole body fat-free mass 0.2 1.0 3.6 0.7 -0.5 0.2 0.3 1.9 -1.6 0.1
Leg fat-free mass (right) 0.1 0.6 1.5 0.7 -0.6 0.1 0.5 1.2 -1.1 -0.5
Arm fat percentage (left) 0.1 0.3 1.1 -1.1 0.8 0.6 -0.1 0.0 0.3 0.1
Average weekly red wine intake 1.3 1.9 4.6 0.8 -0.5 0.9 -1.7 2.1 -1.9 -0.8
Handedness (chirality/laterality): Left-handed 1.0 1.2 2.8 -1.2 1.1 0.0 1.4 1.7 0.9 0.7
Mood swings 0.1 0.3 1.1 0.4 -0.3 0.2 -1.1 0.1 -0.6 0.3
Loneliness, isolation 0.6 0.9 3.1 0.4 -0.7 0.2 -1.1 1.8 -0.4 -1.0
Long-standing illness, disability or infirmity 0.8 1.2 2.5 1.4 -1.6 1.2 0.2 -0.2 -1.5 -0.3
Ever had bowel cancer screening 0.5 0.6 1.4 -0.7 0.8 -1.2 -0.3 1.1 0.2 0.6
Diabetes diagnosed by doctor 0.2 0.4 2.2 0.4 -0.5 -0.1 0.2 1.5 0.1 0.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.6 0.6 -0.7 0.0 -1.3 0.3 -0.3 -0.4
Friendships satisfaction 0.1 0.1 0.6 -0.2 -0.2 0.8 0.3 0.2 -0.3 -0.3
Qualifications: nursing, teaching 0.9 1.3 2.8 1.2 -1.2 1.1 1.7 0.9 -0.4 -1.1
Commuting to job workplace: Walk 0.4 0.4 1.4 -0.1 -0.3 1.2 0.3 -0.7 1.0 -0.1
Eye problems/disorders: Cataract 1.2 1.3 3.5 -1.9 1.7 -0.8 0.7 -0.4 1.1 0.7
Mouth/teeth dental problems: Mouth ulcers 0.7 1.2 2.0 1.4 -1.3 -0.0 1.1 0.7 -1.4 -1.1
Medication for cholesterol 1.2 1.9 4.6 1.5 -1.6 2.1 0.9 -0.5 -1.3 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.7 -0.2 0.1 -0.8 0.0 0.9 0.2 -0.2
Back pain experienced in last month 1.0 1.4 3.5 1.4 -1.2 0.9 -1.1 -0.7 -1.9 -0.6
Mineral and other dietary supplements 1.5 2.1 4.2 -2.1 1.8 0.1 1.9 -1.3 1.3 0.2
Breast cancer (self-reported) 1.0 1.2 4.9 -0.9 1.1 -0.8 0.6 2.2 0.3 0.7
Asthma (self-reported) 0.3 0.7 3.1 0.7 -0.7 0.2 -0.6 -1.8 -0.4 -0.4
Osteoporosis (self-reported) 0.2 0.2 0.5 0.6 0.0 -0.6 0.7 0.1 -0.4 -0.2
Osteoarthritis (self-reported) 0.4 0.6 1.3 -0.3 0.4 0.4 -1.1 1.0 -0.0 1.2
Medication: Aspirin 0.2 0.3 1.0 0.3 -0.1 0.4 -1.0 -0.4 -0.6 0.3
Medication: Gliclazide 2.5 2.9 5.7 2.3 -2.4 0.8 0.5 2.0 -1.4 -1.5
Illnesses of father: None of the above (group 1) 0.8 1.0 4.2 -0.6 0.2 -1.2 0.2 -2.1 0.8 0.4
Smoking status: Current 1.1 1.7 5.0 -1.5 1.3 1.1 2.2 0.5 1.1 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 2.7 1.2 -1.1 -0.1 0.1 -1.6 -1.1 -1.5
Whole body water mass 0.2 1.0 3.5 0.8 -0.6 0.2 0.3 1.9 -1.6 0.1
Leg predicted mass (right) 0.1 0.5 1.6 0.5 -0.4 0.0 0.4 1.3 -1.0 -0.4
Arm fat mass (left) 0.0 0.2 0.5 -0.7 0.6 0.3 -0.1 0.6 -0.2 0.2
Number of self-reported non-cancer illnesses 0.1 0.2 0.5 0.3 -0.3 -0.7 0.5 0.7 -0.2 -0.5
Average weekly champagne plus white wine intake 0.4 0.6 1.8 -0.9 0.5 0.7 0.0 1.3 0.1 0.9
Miserableness 0.9 1.5 4.6 1.1 -1.3 1.3 0.4 -0.8 -0.7 -2.1
Guilty feelings 0.2 0.3 0.9 -0.4 0.3 0.3 -0.2 0.9 -0.1 -0.7
Wears glasses or contact lenses 1.8 2.1 3.6 -1.6 1.7 -1.9 0.2 1.0 1.5 1.6
Ever taken oral contraceptive pill 0.4 0.4 2.4 0.0 0.0 -0.5 1.5 -0.1 -0.3 -0.4
Hearing aid user 0.5 0.6 1.5 -0.4 0.4 -0.8 1.2 1.1 0.7 -0.4
Mother’s age at death 0.4 0.5 1.7 -0.2 0.6 -0.7 -0.1 -1.3 -0.5 0.8
Financial situation satisfaction 0.4 0.4 1.5 -0.2 -0.1 -0.0 1.2 -0.7 0.6 -0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.6 -0.4 0.2 -0.7 -0.8 -0.7 0.5 0.4
Commuting to job workplace: Public transport 0.2 0.2 0.7 0.6 -0.5 0.0 -0.3 0.9 0.1 -0.5
Eye problems/disorders: Glaucoma 0.4 0.4 1.4 -0.5 0.2 -0.7 0.3 0.5 0.7 1.2
Medication: Blood pressure 0.3 0.6 3.1 0.2 -0.2 -1.8 -0.1 1.0 0.2 -0.1
Pain type(s) experienced in last month: Hip pain 0.2 0.3 1.2 -0.0 0.5 0.4 0.1 -0.0 -1.1 0.7
Supplements: Fish oil (including cod liver oil) 2.8 3.6 9.4 2.2 -2.0 0.4 -3.1 1.4 -2.2 -0.1
High cholesterol (Self-reported) 1.3 2.2 4.1 -1.8 1.8 0.3 -2.0 1.9 0.3 1.1
Medication: Bendroflumethiazide 0.3 0.4 1.3 -0.3 0.4 -0.9 -1.1 -0.1 -0.4 -0.2
Medication: Paracetamol 0.2 0.3 1.2 0.3 -0.6 0.6 0.1 -1.1 -0.5 -0.1
Medication: Lisinopril 1.1 1.4 3.3 -1.1 0.9 -1.8 -0.4 0.6 1.8 1.1
Medication: Atorvastatin 1.7 2.1 5.6 -1.4 1.8 -1.0 -0.5 1.7 -0.0 2.4
Illnesses of father: High blood pressure 0.4 0.5 1.8 -0.1 0.5 1.0 -0.2 -1.3 -0.5 -0.4
Alcohol drinker status: Never 0.8 0.9 1.9 -1.0 0.7 0.2 1.4 -1.2 0.8 1.0
Ever smoked 0.8 1.5 5.0 0.4 -0.5 0.9 2.2 -0.6 0.0 -2.0
Basal metabolic rate 0.1 0.8 2.8 0.6 -0.4 0.2 0.3 1.7 -1.4 0.1
Leg fat percentage (left) 0.3 0.9 1.8 -1.3 1.2 0.5 -1.0 1.1 0.3 0.8
Arm fat-free mass (left) 0.2 1.0 4.1 0.6 -0.5 0.1 -0.3 2.0 -1.5 0.3
Number of operations (self-reported) 0.3 0.5 1.5 -0.9 0.6 -0.4 1.2 -0.6 0.4 -0.0
Average weekly beer plus cider intake 0.2 0.2 0.7 0.4 -0.3 0.8 -0.2 -0.4 -0.6 0.1
Irritability 0.6 1.0 2.0 1.3 -1.4 1.1 -0.5 0.3 -1.0 -0.8
Risk taking 0.5 0.8 2.8 -0.8 0.3 1.0 0.4 1.7 0.8 0.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 1.5 -1.2 0.9 0.1 0.6 1.1 1.0 0.6
Fractured/broken bones in last 5 years 1.4 1.7 3.2 1.4 -1.4 1.8 0.8 0.3 -1.5 -1.5
Age started oral contraceptive pill 0.6 0.8 2.9 0.8 -0.7 -0.3 0.7 1.7 -0.9 -0.2
Diastolic blood pressure, automated reading 0.3 1.0 1.7 -1.1 1.3 -1.1 1.2 -0.5 1.0 -0.1
Ever depressed for a whole week 0.7 0.9 2.8 0.4 -0.3 1.3 1.7 0.2 -0.9 -0.7
Unable to work because of sickness or disability 1.7 2.3 4.5 1.5 -1.5 1.8 0.1 -1.3 -1.5 -2.1
Commuting to job workplace: Cycle 0.5 0.6 1.4 0.4 -0.2 1.0 -0.2 -1.1 -0.4 -1.2
Myopia 0.5 0.7 2.7 -0.2 0.4 -0.8 -0.6 -1.6 -0.1 -1.0
Vascular/heart problems diagnosed by doctor 0.0 0.1 0.4 -0.1 -0.1 0.3 -0.6 0.0 0.3 0.6
Cholesterol lowering medication 0.9 1.4 2.9 -1.0 0.9 -0.7 -1.4 1.5 0.5 1.7
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 5.6 -0.2 0.4 -0.5 0.2 2.4 0.2 -0.2
Pain experienced in last month 0.4 0.6 2.9 -0.0 0.1 0.5 -0.8 -1.7 -0.3 -0.7
Supplements: Calcium 0.7 0.7 1.9 0.3 0.0 -1.2 -1.3 -0.1 -0.2 1.4
Basal cell carcinoma (self-reported) 0.3 0.3 1.9 0.3 -0.2 -0.4 -0.1 1.4 -0.3 0.1
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.1 0.3 0.0 0.9 0.9 -0.3 -1.5 -0.7
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.8 0.8 -0.5 1.3 -0.4 0.5 -1.0 -0.7
Heart disease (siblings) 0.3 0.4 0.9 0.8 -0.6 0.4 0.3 0.1 -0.9 -0.9
Alcohol drinker status: Previous 0.4 0.5 2.2 -0.5 0.7 0.1 0.6 -1.5 0.2 -0.2
Pack years of smoking 0.9 1.3 4.2 -1.1 1.3 0.4 0.6 2.1 0.4 1.1
Impedance of whole body 0.3 1.4 2.7 -1.5 1.6 -0.6 0.5 -1.4 0.9 1.3
Leg fat mass (left) 0.1 0.4 1.1 -0.6 0.5 0.7 -0.1 1.1 -0.3 0.3
Arm predicted mass (left) 0.2 1.2 4.9 0.6 -0.4 0.2 0.0 2.2 -1.6 0.5