Hub : Genes

RINL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1050	0.0310	2.9e-05	0.069	0.056	0.072	0.063	0.075	9.1e-09	2.0e-07	3.7e-09	3.4e-08	2.1e-09
2	GTEx	Artery Aorta	0.1780	0.0530	3.2e-04	0.089	NA	0.110	NA	0.112	1.3e-05	NA	1.2e-06	NA	1.0e-06
3	GTEx	Esophagus Mucosa	0.2400	0.0620	1.5e-05	0.117	NA	0.126	NA	0.128	3.1e-08	NA	8.9e-09	NA	6.8e-09
4	GTEx	Skin Sun Exposed Lower leg	0.1000	0.0410	7.3e-03	-0.002	NA	-0.003	NA	0.001	4.9e-01	NA	9.9e-01	NA	2.8e-01
5	GTEx	Spleen	0.2970	0.1090	6.2e-03	0.156	NA	0.064	NA	0.085	8.2e-05	NA	1.0e-02	NA	3.3e-03
6	YFS	Blood	0.0362	0.0105	1.1e-07	0.036	0.022	0.033	0.028	0.040	5.2e-12	5.9e-08	3.9e-11	1.4e-09	3.4e-13
7	TCGA	Kidney Renal Clear Cell Carcinoma	0.0667	0.0349	2.1e-04	0.013	0.038	0.042	NA	0.021	1.1e-02	3.4e-05	1.5e-05	NA	1.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.9	2.8	-0.9	1.1	0.2	-0.8	0.3	0.7	1.7
Bipolar Disorder or Schizophrenia	0.8	1.9	7.9	-0.8	0.9	1.2	-2.8	0.8	0.3	1.2
Depressed Affect (Nagel 2018)	1.9	4.0	6.4	2.3	-2.5	2.2	-1.7	0.4	-2.5	-1.3
Depression (Nagel 2018)	2.2	3.3	5.7	2.2	-2.3	1.4	-1.6	0.3	-2.4	-1.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.3	1.5	-1.4	1.1	0.2	0.1	-1.2	-1.0
Neuroticism (Nagel 2018)	0.5	1.3	2.3	1.1	-1.2	1.5	-1.5	0.3	-1.1	-0.7
Schizophrenia (2018)	0.8	1.7	8.9	-0.3	0.1	1.5	-3.0	0.8	-0.5	0.3
Schizophrenia vs Biploar Disorder	1.8	2.3	7.0	1.2	-1.2	2.6	-0.5	0.7	-1.8	-1.6
Worry (Nagel 2018)	0.2	0.5	1.4	-0.8	1.2	-0.5	-0.2	-0.2	0.8	0.7
Alzheimer’s Disease (in mother)	0.8	1.0	4.5	0.0	-0.3	-0.3	2.1	1.2	0.6	-0.7
Alzheimer’s Disease (in father)	0.8	0.9	3.3	-0.8	1.1	-0.4	-0.8	1.8	-0.2	0.7
Alzheimer’s Disease (including proxy)	1.0	1.4	3.5	0.9	-1.0	0.0	1.7	1.9	-0.2	-1.3
Crohns Disease (2017)	1.2	2.5	3.9	-2.0	2.0	-1.4	0.8	1.2	1.5	1.9
Irritable Bowel Disease (IBD)	1.1	2.6	3.7	-1.6	1.7	-1.9	0.5	1.8	1.5	1.9
Ulcerative Colitis (UC)	0.4	0.7	2.2	-0.1	0.3	-1.5	-0.3	1.3	0.5	0.8
Major Depression (MDD)	0.5	0.6	1.4	0.6	-0.7	0.3	1.1	-1.2	0.0	-0.8
Reaction Time	2.1	4.1	8.1	2.8	-2.7	0.6	1.5	0.6	-1.6	-2.8
Verbal and Numeric Reasoning (VNR)	0.7	1.8	3.6	1.9	-1.9	0.8	-0.2	0.6	-1.4	-1.6
Breast Cancer	0.3	0.7	2.5	0.1	-0.1	-0.8	1.6	0.4	-0.2	-1.3
Ovarian Cancer	0.5	0.7	1.2	-0.8	0.8	-1.0	-0.9	1.1	0.4	0.2
Prostate Cancer	0.6	0.9	4.2	0.6	-1.0	0.1	-2.1	0.1	-0.8	0.0
Age at First Birth	0.5	0.8	2.0	-0.8	1.1	-1.4	0.8	-0.1	0.9	0.6
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.3	1.8	3.2	-1.6	1.8	-0.9	-1.7	0.4	1.0	1.6
Coronary Artery Disease (CAD)	0.8	1.0	4.1	0.4	0.0	0.3	2.0	1.6	0.0	0.0
Crohns Disease (2012)	1.3	2.1	3.4	-1.8	1.8	-1.3	1.1	0.3	1.7	1.4
Mean Putamen Volume	0.1	0.1	0.5	-0.1	0.1	-0.2	-0.2	0.5	0.2	-0.7
Fasting Glucose	0.4	0.5	1.0	0.5	-0.4	-0.8	-0.6	-0.7	-1.0	0.7
HbA1C	0.3	0.3	0.7	0.5	-0.2	-0.8	-0.5	-0.6	-0.7	0.5
HDL Cholesterol	0.5	0.8	2.4	0.6	-0.4	-0.1	1.6	0.5	-0.4	-1.4
LDL Cholesterol	0.4	0.6	1.3	0.7	-0.8	1.1	-0.3	-0.6	-0.7	-0.7
Lupus	1.1	1.7	3.5	1.9	-1.7	0.5	-0.1	1.3	-1.6	-0.8
Neuroticism (2016)	0.2	0.4	1.1	-0.3	0.6	0.0	-0.9	-0.3	0.1	1.0
Primary Biliary Cirrhosis	0.9	1.3	2.5	-1.3	1.6	-1.1	-0.2	0.9	0.9	1.3
Rheumatoid Arthritis	1.6	2.3	4.6	-1.5	1.4	-2.0	-0.6	1.1	2.1	1.2
Schizophrenia (2014)	0.7	1.4	5.1	-0.3	0.2	2.2	-2.3	0.0	-0.4	-0.0
Triglycerides	0.5	0.9	1.4	-1.1	1.0	-0.9	0.6	0.4	1.2	1.0
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.5	-0.2	0.0	-0.1	-0.7	0.3	0.0	0.0
Ulcerative Colitis	0.4	0.6	1.9	0.2	-0.1	-0.8	-1.1	1.4	-0.4	0.3
Blood Eosinophil Count	0.9	6.6	12.7	-3.5	3.6	-2.9	-0.5	-0.6	2.6	2.4
Blood Platelet Count	2.0	23.4	45.0	-6.7	6.6	-4.3	-0.4	-0.4	6.3	4.1
Blood Red Count	0.3	3.2	8.9	-2.0	2.0	-3.0	1.5	0.9	1.5	0.5
Blood White Count	0.9	6.6	12.7	-3.1	2.9	-3.6	-0.4	-1.0	3.2	2.0
Heel T-Score	0.1	1.1	3.3	-0.4	0.7	-1.8	-0.7	1.6	-0.4	0.8
BMI	0.1	0.9	2.1	0.4	-0.6	1.4	-0.5	0.9	-1.2	-1.0
Height	0.3	6.3	21.7	0.5	0.5	-0.2	3.4	4.7	-2.4	2.0
Waist Hip Ratio (WHR)	1.1	5.1	8.5	-2.9	2.9	-2.5	-1.1	1.4	1.8	2.4
Systolic Blood Pressure	0.7	3.7	9.4	-2.0	2.1	-3.1	-1.1	-0.5	2.1	1.2
Smoking Status	0.7	1.6	4.3	1.0	-1.2	1.5	2.1	0.7	-0.3	-1.3
Allergy or Eczema	0.8	2.0	5.6	-1.0	0.8	-2.4	1.4	-0.9	1.9	0.8
Cardiovascular Disease	0.1	0.4	0.8	0.5	-0.4	0.7	-0.7	0.5	-0.8	-0.9
Hypothyroidism (self reported)	0.2	0.4	1.5	0.4	-0.1	-0.0	0.9	1.2	-0.3	-0.2
Respiratory disease	0.1	0.3	1.2	0.1	0.1	0.7	0.7	-1.1	0.2	-0.1
Type 2 Diabetes (T2D) (2018)	0.0	0.0	0.2	0.1	-0.4	0.0	-0.1	0.0	-0.0	-0.2
Lung FEV1/FVC ratio	0.1	0.7	1.6	-0.7	0.5	0.5	1.3	-1.0	1.0	-0.4
Lung FVC	0.1	0.5	1.7	0.5	-0.3	0.0	-0.9	-1.3	-0.6	-0.7
Neuroticism	0.4	0.9	2.8	0.5	-0.6	1.7	-1.1	0.5	-1.1	-0.4
Chronotype (morning person)	0.2	0.5	2.5	-0.4	0.3	-1.6	0.5	-0.8	0.5	-0.1
Hair Pigment	0.0	0.5	0.8	-0.8	0.8	0.6	-0.9	-0.8	0.6	0.6
Tanning	0.2	3.0	6.5	2.4	-2.5	1.5	-0.9	0.2	-2.1	-1.0
Hand grip strength (left)	0.2	0.6	1.9	0.5	-0.2	-0.3	-0.7	1.4	-1.2	0.2
Number of treatments/medications taken	0.5	1.0	4.7	-0.7	0.8	-0.9	0.2	2.2	-0.1	0.2
Average weekly spirits intake	0.3	0.4	1.0	-0.5	1.0	0.1	0.4	0.7	0.1	0.7
Sensitivity / hurt feelings	0.5	0.8	2.3	-0.7	0.5	-0.5	-1.5	-0.2	1.1	1.1
Frequency of depressed mood in last 2 weeks	1.5	2.1	4.5	1.6	-1.7	0.3	-2.1	-0.3	-1.7	-1.4
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.4	-0.3	0.8	-0.4	-0.2	-0.2	-0.2
Relative age of first facial hair	0.4	0.9	2.4	-1.2	1.0	-0.1	0.3	0.9	1.6	0.8
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.2	0.2	-0.2	-0.5	0.0	-0.1	-0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.2	-0.2	0.4	-1.5	1.1	1.0	0.4	0.9
Ever had hysterectomy (womb removed)	1.2	1.3	4.7	0.8	-0.7	0.8	2.2	-0.3	-0.1	-1.6
Systolic blood pressure, automated reading	0.6	1.9	4.3	-1.7	1.8	-2.1	-0.2	0.1	1.3	1.0
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.4	0.3	-0.2	0.4	-0.1	0.3	0.4	-0.6
Angina	1.6	2.1	3.6	-1.7	1.9	-0.8	-0.4	-1.7	1.3	1.6
Medication for hormone replacement therapy	0.8	0.9	2.2	-1.4	1.5	-0.4	-0.9	-0.0	0.7	0.7
Vitamin and mineral supplements	0.9	1.2	3.6	-1.7	1.9	0.1	0.2	0.2	0.5	1.2
Supplements: Zinc	0.1	0.1	0.2	-0.0	0.0	0.4	-0.0	0.4	-0.5	-0.4
Medication: Co-codamol	0.8	0.9	1.5	-1.2	1.2	-0.5	0.6	1.2	1.2	0.3
Medication: Metformin	0.7	1.0	2.1	1.1	-1.2	0.2	1.4	0.7	-1.2	-0.5
Diabetes (father)	2.1	2.6	7.1	-1.3	1.9	-1.4	-0.8	1.4	1.1	2.7
Diabetes (mother)	0.4	0.5	1.7	-0.4	0.6	-0.5	0.9	0.4	0.1	1.3
Severe depression (siblings)	0.2	0.3	0.6	-0.5	0.7	0.1	-0.8	-0.1	0.1	0.7
Pack years adult smoking proportion	0.6	0.9	2.8	-0.9	1.0	0.6	0.4	1.7	0.5	0.9
Impedance of leg (right)	0.2	1.0	3.0	-1.1	1.3	-0.5	0.5	-0.6	0.4	1.7
Leg fat-free mass (left)	0.1	0.5	1.4	0.6	-0.5	0.1	0.3	1.0	-1.2	-0.4
Trunk fat percentage	0.2	0.7	2.2	-1.5	1.4	0.4	0.1	0.3	0.2	0.6
Hand grip strength (right)	0.1	0.3	1.0	0.5	-0.0	-0.7	0.6	0.2	-1.0	0.4
Townsend deprivation index at recruitment	1.0	1.4	3.6	0.8	-0.6	-0.1	-1.3	-1.9	-0.8	-1.8
Current tobacco smoking	1.1	1.8	6.9	-1.4	1.2	0.8	2.6	0.6	1.1	0.3
Average weekly fortified wine intake	0.3	0.4	0.8	-0.9	0.6	-0.8	-0.2	-0.6	0.7	0.5
Maternal smoking around birth	0.7	1.1	2.6	-1.1	1.1	0.1	-1.6	0.4	-0.2	1.6
Fed-up feelings	0.5	1.0	2.4	0.9	-0.6	1.2	-1.0	0.7	-1.6	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.9	0.6	-0.7	1.1	-1.7	0.1	-1.0	-0.4
Relative age voice broke	0.9	1.4	3.8	-1.4	1.1	-0.7	0.3	1.4	1.9	0.7
Taking other prescription medications	0.3	0.4	2.4	0.3	-0.4	-0.5	1.6	-0.0	0.1	0.2
Age when periods started (menarche)	1.1	2.7	8.5	0.8	-1.0	1.9	1.9	-0.4	-1.0	-2.9
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	3.3	0.9	-0.8	-0.4	1.8	0.9	-1.0	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	4.3	0.3	-0.0	-0.8	0.2	2.1	-0.3	-0.3
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	0.3	-0.3	-0.7	0.0	-0.5	0.3	-0.2
Qualifications: CSEs or equivalent	1.5	2.0	3.5	-1.5	1.3	-1.6	-0.8	-0.5	1.9	1.8
Serious illness, injury or assault to yourself	0.3	0.3	1.1	-0.6	0.3	-0.6	0.4	-0.1	1.1	0.3
High blood pressure	0.1	0.4	0.9	-0.1	0.4	-1.0	0.9	0.2	0.3	-0.8
Hayfever, allergic rhinitis or eczema	0.9	2.0	5.7	-1.1	1.1	-2.4	1.4	-0.7	1.6	0.7
Multivitamins +/- minerals	0.5	0.6	1.8	0.9	-1.2	0.2	0.2	-0.3	0.2	-1.3
Stomach or abdominal pain in last month	1.0	1.3	1.9	-1.0	0.9	-1.4	-0.2	1.3	1.4	1.2
Supplements: Glucosamine	0.9	1.2	2.1	-0.8	0.8	-1.5	-1.4	0.4	0.9	1.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	2.3	0.1	-0.2	-0.4	1.5	-0.9	0.4	0.5
Medication: Atenolol	0.1	0.1	0.2	-0.1	-0.4	0.5	-0.4	0.2	0.1	-0.3
Medication: Levothyroxine sodium	1.6	2.8	3.7	-1.9	1.6	-1.6	1.9	1.6	1.7	1.3
Sitting height	0.4	2.7	8.1	1.5	-1.1	0.5	2.9	1.6	-2.2	-0.5
Chronic bronchitis/emphysema (father)	1.5	1.8	3.2	1.3	-1.1	1.3	1.2	1.8	-1.8	-0.0
High blood pressure (mother)	0.4	0.5	1.4	0.3	-0.3	0.9	0.1	-0.8	-0.8	-1.2
Body mass index (BMI)	0.1	0.2	0.6	-0.3	0.0	0.8	-0.5	0.7	-0.2	-0.4
Impedance of leg (left)	0.2	1.2	3.0	-1.3	1.5	-0.4	0.2	-0.6	0.7	1.7
Leg predicted mass (left)	0.1	0.5	1.5	0.7	-0.5	0.2	0.2	1.1	-1.2	-0.3
Trunk fat mass	0.1	0.5	1.1	-1.1	1.0	0.6	0.3	0.8	-0.3	0.5
Waist circumference	0.2	0.6	1.5	-1.2	1.0	0.0	0.0	1.1	0.1	0.4
Number of incorrect matches in round	0.4	0.7	2.6	0.7	-0.9	-1.0	1.6	-0.2	-0.2	0.1
Past tobacco smoking	1.1	2.0	5.7	-1.2	1.3	-1.5	-1.5	0.4	0.7	2.4
Alcohol usually taken with meals	0.4	0.6	2.9	0.1	-0.4	-1.1	-1.7	0.1	0.1	-0.0
Nervous feelings	0.2	0.3	1.0	-0.4	0.7	-1.0	0.2	0.0	0.7	-0.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	5.4	1.4	-1.4	0.9	-2.3	-0.6	-1.6	-1.7
Hearing difficulty/problems with background noise	0.2	0.4	0.7	0.9	-0.8	0.3	0.5	0.7	-0.6	-0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.7	-0.1	-0.0	0.5	0.6	0.4	0.7	-0.8
Had menopause	0.3	0.3	0.7	0.7	-0.5	0.1	0.6	0.7	-0.8	0.1
Had other major operations	0.6	0.7	2.1	0.7	-1.0	0.8	-0.1	-1.4	-0.3	-0.9
Forced vital capacity (FVC)	0.2	0.8	3.1	1.1	-0.7	-0.1	0.0	0.5	-1.8	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.5	0.3	-0.0	-0.8	-0.8	2.1	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.7	-0.9	1.0	1.0	0.8	-1.6	-0.4	0.3
Qualifications: None of the above	0.1	0.3	0.6	-0.6	0.7	-0.6	-0.4	-0.8	0.2	0.2
Financial difficulties in last 2 years	0.3	0.4	1.7	-0.4	0.0	-0.8	0.4	1.3	0.6	0.0
Mouth/teeth dental problems	0.8	1.2	3.9	-1.2	1.3	0.0	-0.5	0.9	0.7	2.0
Heart attack	0.4	0.6	2.1	0.2	0.1	0.8	0.9	-0.2	-1.4	-0.5
Allergy	0.2	0.5	1.4	0.2	-0.0	1.1	-0.3	1.2	-0.9	-0.1
Pain all over the body in last month	2.6	2.8	3.7	1.9	-1.9	1.5	0.5	1.9	-1.8	-1.8
Diabetes (self-reported)	0.1	0.1	0.3	0.4	-0.6	-0.0	-0.2	0.4	-0.1	0.1
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.4	-1.1	0.8	-1.6	0.4	1.2	1.0	0.8
Medication: Ramipril	1.5	2.0	3.9	-2.0	1.8	-1.3	1.0	1.3	1.0	1.0
Medication: Simvastatin	0.5	0.8	1.3	-1.0	0.8	-0.5	-0.4	1.1	1.0	1.1
Fluid intelligence score	0.2	0.4	1.3	0.7	-0.7	0.0	-0.2	1.1	0.2	-0.6
Illnesses of siblings	0.4	0.6	3.5	0.4	-0.4	-0.2	-0.2	1.9	-0.0	0.5
Neuroticism score	0.1	0.1	0.2	-0.4	0.4	0.0	-0.4	0.3	0.1	0.2
Weight	0.1	0.5	2.3	-0.2	0.2	0.4	0.4	1.5	-0.7	0.3
Impedance of arm (right)	0.4	2.0	3.7	-1.5	1.5	-1.5	0.7	-1.9	1.6	0.6
Arm fat percentage (right)	0.1	0.3	1.2	-1.1	0.7	0.4	-0.2	-0.1	0.5	-0.1
Trunk fat-free mass	0.2	1.2	4.5	0.7	-0.4	0.0	0.6	2.1	-1.6	0.4
Hip circumference	0.1	0.6	2.1	0.1	-0.1	1.4	0.2	0.9	-1.1	-0.4
Time employed in main current job	0.8	0.9	2.4	0.9	-1.1	1.6	0.3	0.8	-0.6	-0.9
Alcohol intake versus 10 years previously	0.2	0.3	0.8	-0.2	-0.1	-0.9	-0.5	-0.8	0.4	-0.3
Father’s age at death	0.8	1.0	5.8	-0.3	0.6	0.5	0.0	2.4	-0.3	0.8
Worrier / anxious feelings	0.5	1.0	2.5	-1.1	1.6	-0.7	0.3	1.2	0.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.7	1.3	1.1	-1.1	0.4	-0.9	0.5	-0.9	-0.8
Falls in the last year	1.5	2.0	5.2	1.5	-1.8	1.4	1.0	0.3	-0.7	-2.3
Hair/balding pattern: Pattern 3	0.5	0.8	2.1	-0.8	0.4	-0.6	-0.1	1.1	1.1	1.4
Number of live births	0.1	0.1	0.2	-0.2	0.0	0.5	0.4	-0.3	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.0	0.8	-0.5	-0.4	0.1	-0.1	-1.0	-0.9
Pulse rate	0.5	0.9	3.8	0.3	-0.2	1.1	1.9	-0.8	0.3	-0.6
Happiness	1.4	1.7	4.6	-1.2	1.1	-0.5	1.1	2.1	0.8	1.5
Noisy workplace	0.3	0.3	0.6	0.3	-0.4	0.6	0.6	-0.7	0.5	-0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.2	2.5	-1.3	1.4	-1.0	-1.6	-0.8	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	2.9	0.0	0.3	-0.5	-0.1	-1.7	-0.4	-0.0
Mouth/teeth dental problems: Dentures	0.9	1.5	3.8	-1.2	1.1	-1.7	-0.1	-0.2	2.0	1.1
Asthma	0.4	0.8	4.4	0.6	-0.6	0.2	-0.7	-2.1	-0.1	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.8	0.3	-0.2	1.1	1.1	-1.3	-1.3	-0.7
Medication: Cholesterol lowering	0.8	1.2	2.9	-1.3	1.4	-0.5	-0.7	1.2	0.3	1.7
Depression (self-reported)	0.3	0.4	2.4	-0.0	-0.1	1.6	-0.1	-0.4	-0.2	-0.4
Medication: Lansoprazole	0.2	0.2	0.6	0.2	-0.2	-0.2	-0.5	0.5	-0.7	0.7
Prospective memory result	0.9	1.1	2.9	-0.2	0.3	-1.6	-0.5	-1.2	0.7	1.7
Lung cancer (father)	1.3	1.6	2.1	1.2	-1.5	1.3	-1.4	0.6	-1.0	-1.4
Illnesses of mother	0.3	0.4	1.2	-0.3	0.1	-0.6	-0.5	-0.5	1.1	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.7	0.9	-0.7	-1.0	0.0	-0.4	-1.0	-1.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.3	-0.9	1.1	-0.4	-0.4	-0.9	0.3	0.5
Impedance of arm (left)	0.3	1.3	3.3	-1.3	1.3	-0.5	0.9	-1.8	0.8	0.8
Arm fat mass (right)	0.0	0.2	0.4	-0.6	0.4	0.4	0.2	0.6	-0.2	0.1
Trunk predicted mass	0.2	1.2	4.3	0.7	-0.5	-0.0	0.6	2.1	-1.6	0.4
Standing height	0.2	2.0	4.6	0.1	0.5	-0.9	2.1	2.0	-1.5	1.5
Length of working week for main job	0.8	0.9	2.4	0.9	-1.2	1.0	0.2	0.5	-0.4	-1.5
Exposure to tobacco smoke at home	1.6	1.8	3.1	1.7	-1.7	1.8	0.8	-0.8	-0.9	-1.3
Breastfed as a baby	0.1	0.2	0.3	-0.3	0.3	0.2	0.5	0.5	0.4	-0.5
Tense / ‘highly strung’	0.1	0.1	0.3	0.4	-0.4	-0.3	0.3	-0.2	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.4	-0.1	0.1	0.4	-0.5	0.7	-0.3	-0.5
Hair/balding pattern: Pattern 4	1.4	3.4	6.6	2.2	-2.2	2.6	1.4	-0.6	-2.0	-1.1
Birth weight of first child	0.3	0.6	1.8	1.3	-0.9	-0.3	-0.9	-0.4	-0.8	0.1
Peak expiratory flow (PEF)	0.2	0.4	1.4	0.4	-0.2	-0.5	-0.0	-0.8	-0.3	-1.2
Pulse wave reflection index	0.3	0.3	1.0	-0.5	0.4	-0.8	-1.0	-0.3	0.2	0.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.0	1.6	-1.7	0.9	1.1	-0.5	-1.6	-1.7
Loud music exposure frequency	0.9	1.0	2.1	1.4	-1.5	1.2	1.1	0.4	-0.7	0.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	5.4	-1.1	1.3	-0.9	-2.3	-0.2	0.1	1.2
Mouth/teeth dental problems: Bleeding gums	3.3	4.3	10.7	2.0	-1.9	1.0	0.6	-2.6	-2.0	-3.3
Blood clot in the leg (DVT)	0.6	0.7	2.1	0.9	-0.5	1.5	-0.5	0.2	-1.1	-0.7
Medication: Paracetamol	0.0	0.0	0.2	-0.2	0.1	-0.2	0.1	-0.4	-0.2	0.1
Headache pain in last month	1.0	1.7	3.3	1.3	-1.4	0.1	1.6	1.2	-1.2	-1.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.6	0.8	-1.1	0.8	0.6	-1.3	-0.1	-1.2
Glaucoma (self-reported)	0.3	0.4	0.8	-0.6	0.2	-0.9	-0.2	0.3	0.9	0.8
Gout (self-reported)	0.3	0.4	2.2	0.2	0.3	-0.5	0.2	1.5	-0.4	0.3
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	1.6	-0.0	0.0	-0.7	0.8	1.3	0.4	-0.6
Medication: Amlodipine	1.5	2.1	4.2	-1.8	1.7	-1.2	-0.5	2.1	1.7	0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.7	-0.1	0.2	0.1	-0.8	0.1	0.2	-0.5
Birth weight	1.6	3.5	5.8	-2.1	2.1	-0.9	-2.0	0.3	2.2	2.4
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.5	0.8	-0.5	0.8	1.9	-0.8	-1.4	-1.6
High blood pressure (siblings)	0.8	1.2	5.9	0.2	-0.3	0.5	0.4	-2.4	-0.6	-1.3
Forced vital capacity (FVC), Best measure	0.4	1.4	3.8	1.6	-1.2	-0.4	0.3	0.1	-1.9	-1.3
Body fat percentage	0.1	0.4	1.3	-1.1	1.0	0.7	-0.1	0.3	-0.0	0.3
Leg fat percentage (right)	0.2	0.8	1.5	-1.2	1.1	0.6	-0.7	1.1	0.1	0.9
Arm fat-free mass (right)	0.3	1.4	4.0	0.8	-0.5	0.8	0.1	2.0	-2.0	0.4
Exposure to tobacco smoke outside home	1.0	1.3	5.7	0.7	-0.9	2.4	-1.3	0.2	-0.5	-0.6
Comparative body size at age 10	0.1	0.3	1.3	0.5	-0.1	-1.1	-0.0	0.5	-0.0	-0.3
Number of full brothers	1.2	1.6	8.6	0.5	-0.8	0.5	0.3	-2.9	-0.1	-1.0
Worry too long after embarrassment	0.4	0.7	1.8	-0.3	0.3	-1.2	-0.9	0.8	0.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	3.5	1.6	-1.9	1.6	0.5	-0.5	-1.7	-1.9
Wheeze or whistling in the chest in last year	0.1	0.2	0.6	0.1	-0.3	0.2	0.7	0.5	0.2	-0.8
Number of children fathered	0.2	0.2	0.9	-0.3	0.2	-0.4	0.9	0.5	0.4	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.4	1.2	-1.1	0.8	-0.4	0.3	-0.7	-1.0
Age at first live birth	0.3	0.5	1.1	0.5	-0.6	-0.6	0.9	-1.0	-0.6	-0.5
Pulse wave peak to peak time	0.4	0.4	1.0	0.8	-1.0	0.2	0.4	0.9	-0.4	-0.4
Health satisfaction	0.3	0.4	1.2	0.3	-0.6	1.1	1.0	-0.6	0.0	-0.1
Shortness of breath walking on level ground	1.3	1.5	4.6	1.0	-1.1	2.1	-0.7	-1.3	-0.7	-1.0
Qualifications: College or University degree	0.5	1.5	2.3	1.4	-1.3	1.2	0.9	1.5	-0.9	-1.4
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.2	-0.1	-0.5	0.6	0.0	0.2	-0.2
Mouth/teeth dental problems: Loose teeth	2.4	2.8	5.8	2.4	-2.4	1.2	1.5	0.2	-0.9	-2.0
Emphysema/chronic bronchitis	0.4	0.4	1.8	-0.3	0.5	0.2	0.5	1.3	-0.3	0.8
Medication for pain relief, constipation, heartburn	0.3	0.4	1.7	-0.4	0.3	-0.9	-0.1	-0.4	1.3	0.5
Neck or shoulder pain in last month	0.3	0.5	2.6	-0.4	0.5	-0.3	0.0	-1.6	0.3	0.5
Medication: Blood pressure	0.5	0.9	2.1	-1.1	1.2	-0.7	0.0	1.4	0.6	0.8
Angina (self-reported)	1.2	1.5	3.0	-1.3	1.5	-0.6	-0.3	-1.7	0.9	1.5
Migraine (self-reported)	0.7	0.9	5.1	0.6	-0.4	0.7	0.0	-0.0	-2.3	-0.1
Medication: Ibuprofen	0.4	0.5	1.2	0.4	-0.3	0.8	0.8	-0.7	-1.1	-0.4
Medication: Allopurinol	0.4	0.5	2.0	0.6	-0.2	-0.1	1.4	0.8	-0.5	-0.1
Medication: Omeprazole	0.9	1.1	6.1	-0.6	0.7	-0.5	-0.0	2.5	0.5	0.3
Medication: Seretide 50 evohaler	2.4	2.8	5.1	-2.3	2.2	-1.2	1.1	1.0	1.5	1.9
Mean time to correctly identify matches	1.9	3.6	7.7	2.8	-2.5	-0.2	1.1	1.2	-1.9	-2.3
Heart disease (mother)	0.4	0.5	1.1	0.9	-0.4	-0.2	-0.9	0.8	-1.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.8	-0.8	0.7	0.2	-0.6	0.4	0.9	0.5
Whole body fat mass	0.1	0.3	0.6	-0.7	0.6	0.6	0.1	0.8	-0.6	0.3
Leg fat mass (right)	0.1	0.4	0.9	-0.6	0.5	0.7	0.1	1.0	-0.4	0.5
Arm predicted mass (right)	0.2	1.2	4.0	0.5	-0.3	0.6	0.2	2.0	-1.8	0.6
Pulse rate, automated reading	0.3	1.0	2.2	-0.8	1.0	0.6	1.5	-1.3	0.8	0.3
Alcohol intake frequency.	0.3	0.7	3.5	-0.2	-0.1	-0.2	0.2	-1.9	1.0	-0.4
Comparative height size at age 10	0.5	2.9	13.2	-1.0	1.6	-1.2	0.3	1.4	-0.5	3.6
Number of full sisters	0.3	0.4	1.3	0.1	-0.6	0.3	-0.4	-1.1	0.8	-0.5
Suffer from ‘nerves’	0.4	0.6	2.1	-0.5	0.7	-0.8	-1.4	-0.7	0.5	0.5
Overall health rating	1.3	2.7	6.5	1.6	-1.8	2.1	0.1	-1.0	-1.1	-2.5
Chest pain or discomfort	0.9	1.4	7.1	0.5	-0.5	0.3	-2.7	1.1	-0.7	-0.2
Had major operations	0.5	0.6	2.2	-0.8	0.6	0.4	1.5	0.9	0.5	0.0
Age at last live birth	1.2	1.8	4.0	1.9	-2.0	0.5	-0.4	-0.7	-1.3	-1.5
Family relationship satisfaction	0.6	0.7	2.9	0.4	-0.5	0.3	1.7	-0.8	-0.7	-0.7
Leg pain on walking	1.2	1.5	2.3	1.5	-1.5	1.1	-0.8	-1.5	-0.9	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.5	-0.8	0.6	-0.4	1.2	0.2	0.5	-0.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.5	0.2	-0.4	1.6	-0.7	0.1	-1.2	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.8	-0.5	0.4	-0.1	-0.1	0.9	0.6	0.1
Medication: Aspirin	0.3	0.4	1.5	0.3	-0.1	0.4	-1.2	-0.2	-0.8	0.4
Supplements: Vitamin C	0.2	0.2	0.6	0.7	-0.5	-0.6	-0.2	-0.0	-0.7	-0.1
Knee pain experienced in last month	0.2	0.3	0.9	0.2	-0.2	1.0	0.0	0.4	-0.7	-0.4
Hypertension (Self-reported)	0.2	0.5	2.6	-0.0	0.2	-1.6	0.7	0.6	0.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	1.2	-0.1	0.1	0.1	-0.6	1.1	0.3	-0.5
Illnesses of father: Heart disease	0.7	0.9	2.0	1.0	-0.7	0.8	-1.4	0.9	-1.3	-0.2
Illnesses of siblings: Diabetes	0.5	0.6	2.1	0.6	-0.4	-1.5	-0.8	0.4	-0.6	0.5
Smoking status: Previous	1.1	1.6	4.8	1.4	-1.5	0.9	0.7	-0.6	-0.5	-2.2
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.5	1.2	-0.7	0.2	0.4	0.2	-1.6	-0.6
Whole body fat-free mass	0.2	1.0	3.6	0.7	-0.5	0.2	0.3	1.9	-1.6	0.1
Leg fat-free mass (right)	0.1	0.6	1.5	0.7	-0.6	0.1	0.5	1.2	-1.1	-0.5
Arm fat percentage (left)	0.1	0.3	1.1	-1.1	0.8	0.6	-0.1	0.0	0.3	0.1
Average weekly red wine intake	1.3	1.9	4.6	0.8	-0.5	0.9	-1.7	2.1	-1.9	-0.8
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.8	-1.2	1.1	0.0	1.4	1.7	0.9	0.7
Mood swings	0.1	0.3	1.1	0.4	-0.3	0.2	-1.1	0.1	-0.6	0.3
Loneliness, isolation	0.6	0.9	3.1	0.4	-0.7	0.2	-1.1	1.8	-0.4	-1.0
Long-standing illness, disability or infirmity	0.8	1.2	2.5	1.4	-1.6	1.2	0.2	-0.2	-1.5	-0.3
Ever had bowel cancer screening	0.5	0.6	1.4	-0.7	0.8	-1.2	-0.3	1.1	0.2	0.6
Diabetes diagnosed by doctor	0.2	0.4	2.2	0.4	-0.5	-0.1	0.2	1.5	0.1	0.0
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.6	0.6	-0.7	0.0	-1.3	0.3	-0.3	-0.4
Friendships satisfaction	0.1	0.1	0.6	-0.2	-0.2	0.8	0.3	0.2	-0.3	-0.3
Qualifications: nursing, teaching	0.9	1.3	2.8	1.2	-1.2	1.1	1.7	0.9	-0.4	-1.1
Commuting to job workplace: Walk	0.4	0.4	1.4	-0.1	-0.3	1.2	0.3	-0.7	1.0	-0.1
Eye problems/disorders: Cataract	1.2	1.3	3.5	-1.9	1.7	-0.8	0.7	-0.4	1.1	0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.0	1.4	-1.3	-0.0	1.1	0.7	-1.4	-1.1
Medication for cholesterol	1.2	1.9	4.6	1.5	-1.6	2.1	0.9	-0.5	-1.3	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.7	-0.2	0.1	-0.8	0.0	0.9	0.2	-0.2
Back pain experienced in last month	1.0	1.4	3.5	1.4	-1.2	0.9	-1.1	-0.7	-1.9	-0.6
Mineral and other dietary supplements	1.5	2.1	4.2	-2.1	1.8	0.1	1.9	-1.3	1.3	0.2
Breast cancer (self-reported)	1.0	1.2	4.9	-0.9	1.1	-0.8	0.6	2.2	0.3	0.7
Asthma (self-reported)	0.3	0.7	3.1	0.7	-0.7	0.2	-0.6	-1.8	-0.4	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.5	0.6	0.0	-0.6	0.7	0.1	-0.4	-0.2
Osteoarthritis (self-reported)	0.4	0.6	1.3	-0.3	0.4	0.4	-1.1	1.0	-0.0	1.2
Medication: Aspirin	0.2	0.3	1.0	0.3	-0.1	0.4	-1.0	-0.4	-0.6	0.3
Medication: Gliclazide	2.5	2.9	5.7	2.3	-2.4	0.8	0.5	2.0	-1.4	-1.5
Illnesses of father: None of the above (group 1)	0.8	1.0	4.2	-0.6	0.2	-1.2	0.2	-2.1	0.8	0.4
Smoking status: Current	1.1	1.7	5.0	-1.5	1.3	1.1	2.2	0.5	1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.7	1.2	-1.1	-0.1	0.1	-1.6	-1.1	-1.5
Whole body water mass	0.2	1.0	3.5	0.8	-0.6	0.2	0.3	1.9	-1.6	0.1
Leg predicted mass (right)	0.1	0.5	1.6	0.5	-0.4	0.0	0.4	1.3	-1.0	-0.4
Arm fat mass (left)	0.0	0.2	0.5	-0.7	0.6	0.3	-0.1	0.6	-0.2	0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.3	-0.3	-0.7	0.5	0.7	-0.2	-0.5
Average weekly champagne plus white wine intake	0.4	0.6	1.8	-0.9	0.5	0.7	0.0	1.3	0.1	0.9
Miserableness	0.9	1.5	4.6	1.1	-1.3	1.3	0.4	-0.8	-0.7	-2.1
Guilty feelings	0.2	0.3	0.9	-0.4	0.3	0.3	-0.2	0.9	-0.1	-0.7
Wears glasses or contact lenses	1.8	2.1	3.6	-1.6	1.7	-1.9	0.2	1.0	1.5	1.6
Ever taken oral contraceptive pill	0.4	0.4	2.4	0.0	0.0	-0.5	1.5	-0.1	-0.3	-0.4
Hearing aid user	0.5	0.6	1.5	-0.4	0.4	-0.8	1.2	1.1	0.7	-0.4
Mother’s age at death	0.4	0.5	1.7	-0.2	0.6	-0.7	-0.1	-1.3	-0.5	0.8
Financial situation satisfaction	0.4	0.4	1.5	-0.2	-0.1	-0.0	1.2	-0.7	0.6	-0.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.4	0.2	-0.7	-0.8	-0.7	0.5	0.4
Commuting to job workplace: Public transport	0.2	0.2	0.7	0.6	-0.5	0.0	-0.3	0.9	0.1	-0.5
Eye problems/disorders: Glaucoma	0.4	0.4	1.4	-0.5	0.2	-0.7	0.3	0.5	0.7	1.2
Medication: Blood pressure	0.3	0.6	3.1	0.2	-0.2	-1.8	-0.1	1.0	0.2	-0.1
Pain type(s) experienced in last month: Hip pain	0.2	0.3	1.2	-0.0	0.5	0.4	0.1	-0.0	-1.1	0.7
Supplements: Fish oil (including cod liver oil)	2.8	3.6	9.4	2.2	-2.0	0.4	-3.1	1.4	-2.2	-0.1
High cholesterol (Self-reported)	1.3	2.2	4.1	-1.8	1.8	0.3	-2.0	1.9	0.3	1.1
Medication: Bendroflumethiazide	0.3	0.4	1.3	-0.3	0.4	-0.9	-1.1	-0.1	-0.4	-0.2
Medication: Paracetamol	0.2	0.3	1.2	0.3	-0.6	0.6	0.1	-1.1	-0.5	-0.1
Medication: Lisinopril	1.1	1.4	3.3	-1.1	0.9	-1.8	-0.4	0.6	1.8	1.1
Medication: Atorvastatin	1.7	2.1	5.6	-1.4	1.8	-1.0	-0.5	1.7	-0.0	2.4
Illnesses of father: High blood pressure	0.4	0.5	1.8	-0.1	0.5	1.0	-0.2	-1.3	-0.5	-0.4
Alcohol drinker status: Never	0.8	0.9	1.9	-1.0	0.7	0.2	1.4	-1.2	0.8	1.0
Ever smoked	0.8	1.5	5.0	0.4	-0.5	0.9	2.2	-0.6	0.0	-2.0
Basal metabolic rate	0.1	0.8	2.8	0.6	-0.4	0.2	0.3	1.7	-1.4	0.1
Leg fat percentage (left)	0.3	0.9	1.8	-1.3	1.2	0.5	-1.0	1.1	0.3	0.8
Arm fat-free mass (left)	0.2	1.0	4.1	0.6	-0.5	0.1	-0.3	2.0	-1.5	0.3
Number of operations (self-reported)	0.3	0.5	1.5	-0.9	0.6	-0.4	1.2	-0.6	0.4	-0.0
Average weekly beer plus cider intake	0.2	0.2	0.7	0.4	-0.3	0.8	-0.2	-0.4	-0.6	0.1
Irritability	0.6	1.0	2.0	1.3	-1.4	1.1	-0.5	0.3	-1.0	-0.8
Risk taking	0.5	0.8	2.8	-0.8	0.3	1.0	0.4	1.7	0.8	0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.5	-1.2	0.9	0.1	0.6	1.1	1.0	0.6
Fractured/broken bones in last 5 years	1.4	1.7	3.2	1.4	-1.4	1.8	0.8	0.3	-1.5	-1.5
Age started oral contraceptive pill	0.6	0.8	2.9	0.8	-0.7	-0.3	0.7	1.7	-0.9	-0.2
Diastolic blood pressure, automated reading	0.3	1.0	1.7	-1.1	1.3	-1.1	1.2	-0.5	1.0	-0.1
Ever depressed for a whole week	0.7	0.9	2.8	0.4	-0.3	1.3	1.7	0.2	-0.9	-0.7
Unable to work because of sickness or disability	1.7	2.3	4.5	1.5	-1.5	1.8	0.1	-1.3	-1.5	-2.1
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.4	-0.2	1.0	-0.2	-1.1	-0.4	-1.2
Myopia	0.5	0.7	2.7	-0.2	0.4	-0.8	-0.6	-1.6	-0.1	-1.0
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.4	-0.1	-0.1	0.3	-0.6	0.0	0.3	0.6
Cholesterol lowering medication	0.9	1.4	2.9	-1.0	0.9	-0.7	-1.4	1.5	0.5	1.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	5.6	-0.2	0.4	-0.5	0.2	2.4	0.2	-0.2
Pain experienced in last month	0.4	0.6	2.9	-0.0	0.1	0.5	-0.8	-1.7	-0.3	-0.7
Supplements: Calcium	0.7	0.7	1.9	0.3	0.0	-1.2	-1.3	-0.1	-0.2	1.4
Basal cell carcinoma (self-reported)	0.3	0.3	1.9	0.3	-0.2	-0.4	-0.1	1.4	-0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.1	0.3	0.0	0.9	0.9	-0.3	-1.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.8	0.8	-0.5	1.3	-0.4	0.5	-1.0	-0.7
Heart disease (siblings)	0.3	0.4	0.9	0.8	-0.6	0.4	0.3	0.1	-0.9	-0.9
Alcohol drinker status: Previous	0.4	0.5	2.2	-0.5	0.7	0.1	0.6	-1.5	0.2	-0.2
Pack years of smoking	0.9	1.3	4.2	-1.1	1.3	0.4	0.6	2.1	0.4	1.1
Impedance of whole body	0.3	1.4	2.7	-1.5	1.6	-0.6	0.5	-1.4	0.9	1.3
Leg fat mass (left)	0.1	0.4	1.1	-0.6	0.5	0.7	-0.1	1.1	-0.3	0.3
Arm predicted mass (left)	0.2	1.2	4.9	0.6	-0.4	0.2	0.0	2.2	-1.6	0.5