TWAS hub - RLN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Colon Adenocarcinoma	0.0780	0.0400	0.0030	-0.005	0.027	-0.003	NA	-0.005	0.86000	0.01100	0.5800	NA	0.91000
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0544	0.0321	0.0074	0.027	0.007	0.018	NA	0.014	0.00049	0.05200	0.0039	NA	0.00980
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0800	0.0380	0.0015	0.058	0.059	0.047	NA	0.055	0.00031	0.00027	0.0011	NA	0.00044
4	TCGA	Brain Lower Grade Glioma	0.0284	0.0157	0.0080	0.022	0.009	0.010	NA	0.016	0.00130	0.02700	0.0220	NA	0.00570
5	TCGA	Prostate Adenocarcinoma	0.0470	0.0280	0.0073	0.015	0.013	0.014	NA	0.013	0.00930	0.01400	0.0110	NA	0.01400

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Osteoporosis (self-reported)	4.5	5.6	9.2	-1.7	-1.6	-3.0	-2.2	-2.9
Blood Platelet Count	4.1	48.0	104.0	-4.6	0.1	-9.2	-5.5	-10.2
Medication: Omeprazole (e.g. Zanprol)	3.9	4.8	6.8	-1.8	-1.8	-2.4	-2.6	-2.2
Ulcerative Colitis (UC)	3.6	6.8	15.3	-0.3	0.3	3.9	2.3	3.6
Chronic bronchitis/emphysema (father)	3.6	4.2	5.2	-2.3	-2.3	-1.6	-2.2	-1.8
Heel bone mineral density (BMD) T-score, automated (right)	3.5	8.1	9.7	-2.6	-3.1	-2.9	-3.1	-2.4
Allergy	3.5	8.0	13.9	-2.6	-0.5	-3.7	-2.5	-3.6
Medication: Lisinopril	3.5	4.6	7.5	-1.9	-2.0	-2.7	-2.3	-1.6
Alzheimer’s Disease (in mother)	3.2	3.7	5.2	-2.2	-1.0	-2.3	-1.6	-2.2
Qualifications: O levels/GCSEs or equivalent	3.2	5.1	6.5	2.1	2.5	2.5	2.2	1.9
Average weekly fortified wine intake	3.1	3.7	4.4	2.1	1.8	2.1	2.0	1.7
Shortness of breath walking on level ground	3.0	3.6	5.5	-2.1	-0.9	-2.3	-1.7	-2.1
Medication: Gliclazide	3.0	3.3	7.1	-1.4	-0.9	-2.7	-1.9	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.9	6.5	9.4	-1.9	-2.6	-3.1	-2.6	-2.3
Tense / ‘highly strung’	2.9	4.9	6.7	2.3	1.8	2.6	2.2	2.1
Cholesterol lowering medication	2.9	4.2	7.1	-2.7	-1.0	-2.3	-1.8	-2.1
Ever highly irritable/argumentative for 2 days	2.8	3.3	7.8	-1.1	-1.5	-2.8	-1.7	-1.5
Medication for hormone replacement therapy	2.7	3.0	3.7	1.5	1.9	1.8	1.7	1.7
Alcohol usually taken with meals	2.7	4.4	8.2	1.7	1.1	2.3	2.1	2.9
Breastfed as a baby	2.5	3.2	5.4	2.3	1.8	1.4	1.8	1.4
Frequency of tiredness / lethargy in last 2 weeks	2.4	3.8	6.1	-1.5	-2.1	-2.5	-1.9	-1.6
Illnesses of father: None of the above (group 1)	2.3	2.8	4.3	1.8	2.1	1.6	1.7	1.2
Breast Cancer	2.2	5.2	7.4	2.7	1.1	2.3	2.4	2.5
Had menopause	2.2	2.8	4.0	-1.6	-0.5	-2.0	-1.8	-2.0
Illnesses of mother	2.2	2.8	4.2	2.0	0.9	2.0	1.3	1.8
Commuting to job workplace: Walk	2.2	2.4	5.6	2.4	1.4	0.4	1.2	1.6
Falls in the last year	2.1	2.9	4.2	1.8	0.9	1.6	1.9	2.0
Leg fat percentage (right)	2.1	7.5	10.1	-3.2	-2.4	-2.9	-2.6	-2.5
Number of children fathered	2.1	2.3	3.7	-1.6	-1.9	-1.3	-1.8	-0.4
Age at first live birth	2.1	3.8	7.7	2.8	0.3	1.0	1.6	2.7
Body Mass Index (BMI) (2010)	2.0	2.7	3.4	1.6	1.7	1.3	1.8	1.9
Pulse wave reflection index	2.0	2.4	7.1	-1.4	-2.7	-0.8	-1.5	-0.5
Severe depression (siblings)	1.9	2.2	3.1	-1.8	-1.3	-1.2	-1.7	-1.3
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.4	-1.8	-0.9	-2.1	-1.2	-1.0
Pulse wave peak to peak time	1.9	2.2	4.5	1.4	2.1	1.3	1.4	1.0
Irritable Bowel Disease (IBD)	1.8	4.4	11.4	-0.3	-1.1	3.4	1.1	2.9
Ulcerative Colitis	1.8	2.6	7.4	-0.8	-0.2	2.7	1.2	1.9
Blood Eosinophil Count	1.8	14.0	29.8	0.9	-3.2	5.1	1.7	5.5
Hypothyroidism (self reported)	1.8	4.1	7.0	-2.6	-1.5	-1.9	-2.1	-1.9
Hearing difficulty/problems: Yes	1.8	2.7	5.1	-1.1	-1.4	-2.2	-1.7	-1.5
Hayfever, allergic rhinitis or eczema	1.8	3.9	8.4	1.4	-0.4	2.5	1.6	2.9
Leg fat percentage (left)	1.8	6.6	9.5	-3.1	-2.2	-2.7	-2.5	-2.3
Qualifications: A levels/AS levels or equivalent	1.7	3.8	4.2	1.9	2.1	1.9	2.0	2.0
Medication: Amlodipine	1.7	2.4	4.9	1.1	2.2	0.7	1.9	1.3
Eye problems/disorders: Glaucoma	1.7	2.0	4.3	-1.4	0.6	-1.4	-1.1	-2.1
Primary Biliary Cirrhosis	1.6	2.3	3.7	-0.9	-1.3	-1.5	-1.9	-1.7
High blood pressure (mother)	1.6	2.2	4.4	-1.4	-0.6	-2.1	-1.2	-1.6
Had other major operations	1.6	1.9	2.8	-0.8	-1.1	-1.6	-1.7	-1.6
Hayfever/allergic rhinitis (self-reported)	1.6	2.2	6.6	-1.6	-2.6	0.2	-1.2	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.6	1.8	3.4	1.4	1.8	0.9	1.3	1.2
Medication: Blood pressure	1.6	3.0	4.3	-2.0	-0.8	-2.1	-1.6	-1.8
Lupus	1.5	2.2	3.8	1.3	0.6	1.3	1.9	1.9
Schizophrenia (2014)	1.5	3.3	4.0	-1.8	-1.6	-2.0	-1.9	-1.9
Qualifications: CSEs or equivalent	1.5	1.9	3.8	1.1	0.2	1.9	1.3	1.7
Nervous feelings	1.5	2.8	6.0	2.5	1.6	1.7	1.2	0.9
Pulse wave Arterial Stiffness index	1.5	1.7	3.7	-1.3	-1.9	-1.0	-1.2	-0.8
Alzheimer’s Disease (including proxy)	1.4	2.0	4.1	-1.5	-1.1	-2.0	-0.9	-1.3
Angina	1.4	1.8	3.3	-0.8	-0.7	-1.8	-1.5	-1.6
Overall health rating	1.4	3.0	3.7	-1.4	-1.9	-1.5	-1.9	-1.8
Asthma (self-reported)	1.4	2.9	5.3	1.7	-0.1	2.3	1.5	2.0
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.8	-1.6	-2.0	-0.4	-0.9	-1.1
Alcohol drinker status: Never	1.4	1.6	3.4	-1.3	-0.5	-1.9	-1.0	-1.4
HbA1C	1.3	1.4	3.0	0.9	1.7	0.9	1.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.4	1.8	1.4	0.3	1.2	0.7
Medication: Ventolin 100micrograms inhaler	1.3	1.6	2.1	1.0	1.0	1.5	1.4	1.4
Medication: Omeprazole	1.3	1.5	2.8	-1.2	-0.9	-1.1	-1.7	-1.2
Leg pain on walking	1.3	1.7	3.2	-1.8	-1.7	-1.1	-1.0	-0.6
Long-standing illness, disability or infirmity	1.3	2.0	3.5	-1.3	-1.9	-1.3	-1.6	-0.9
Tinnitus: Yes, now most or all of the time	1.3	1.5	1.8	1.3	1.3	1.1	1.1	1.3
Schizophrenia (2018)	1.2	2.5	3.6	-1.1	-0.7	-1.9	-1.8	-1.9
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	3.4	1.0	1.8	0.8	1.2	0.6
Medication: Co-codamol	1.2	1.4	3.1	-0.7	-0.3	-1.4	-1.2	-1.8
Medication: Metformin	1.2	1.6	2.4	-1.6	-0.4	-1.4	-1.2	-1.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	5.7	-2.4	0.1	-0.5	-0.7	-0.9
Father’s age at death	1.2	1.6	3.3	1.8	1.3	0.5	1.3	1.1
Mouth/teeth dental problems: Dentures	1.2	2.1	5.8	-1.4	-0.2	-1.0	-1.3	-2.4
Exposure to tobacco smoke outside home	1.2	1.5	2.1	-1.3	-1.2	-1.1	-1.4	-1.2
Mouth/teeth dental problems: Loose teeth	1.2	1.4	3.2	-1.8	-0.8	-0.8	-1.3	-0.9
Migraine (self-reported)	1.2	1.5	2.5	0.8	1.0	1.2	1.6	1.4
Number of full sisters	1.2	1.5	2.7	-1.6	-0.8	-1.1	-1.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.2	1.5	2.6	0.4	1.6	0.9	1.5	1.3
Body mass index (BMI)	1.1	4.7	6.6	-2.6	-1.7	-2.5	-1.9	-1.9
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.8	3.9	2.0	1.2	1.0	1.2	1.0
Asthma	1.1	2.2	4.0	1.4	-0.4	2.0	1.2	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.0	-1.3	-0.9	-1.4	-1.0	-1.1
Angina (self-reported)	1.1	1.4	2.9	-0.7	-0.6	-1.7	-1.3	-1.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	2.2	-0.8	-1.3	-1.5	-1.2	-1.0
Friendships satisfaction	1.1	1.3	3.2	-1.8	0.1	-1.4	-0.7	-0.9
Back pain experienced in last month	1.1	1.6	3.0	-0.9	-1.7	-1.3	-1.0	-1.2
Average weekly champagne plus white wine intake	1.1	1.5	3.4	0.6	0.9	0.7	1.5	1.8
Ever taken oral contraceptive pill	1.1	1.2	2.5	0.6	0.7	1.6	1.2	1.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	1.6	0.8	1.0	1.0	1.2	1.0
Impedance of arm (right)	1.0	4.4	8.1	1.6	0.5	2.8	2.1	2.6
Worrier / anxious feelings	1.0	1.9	4.5	2.1	1.3	0.8	1.2	1.1
Impedance of arm (left)	1.0	4.5	7.6	1.7	0.5	2.7	2.1	2.8
Supplements: Vitamin C	1.0	1.2	2.1	0.9	0.3	1.4	1.2	1.2
Hypertension (Self-reported)	1.0	2.7	5.0	-1.5	-1.0	-2.2	-1.6	-1.6
Average weekly red wine intake	1.0	1.4	2.3	1.1	1.5	1.0	1.0	1.3
Qualifications: nursing, teaching	1.0	1.6	2.1	1.5	1.4	1.3	1.0	1.0
Bipolar Disorder or Schizophrenia	0.9	2.1	3.6	-1.3	-1.0	-1.9	-1.5	-1.4
Major Depression (MDD)	0.9	1.1	2.5	-1.2	-0.2	-0.7	-0.9	-1.6
Fasting Glucose	0.9	1.1	2.7	-0.4	-1.6	-0.8	-1.3	-0.7
High blood pressure	0.9	2.5	5.1	-1.4	-1.0	-2.2	-1.5	-1.6
Emphysema/chronic bronchitis	0.9	1.0	2.0	1.4	1.2	1.1	0.8	0.2
Leg fat mass (right)	0.9	3.6	6.4	-2.5	-1.5	-2.0	-1.7	-1.6
Mother’s age at death	0.9	1.2	1.8	1.0	1.3	1.2	0.9	1.0
Medication: Bendroflumethiazide	0.9	1.4	2.6	-1.6	-0.5	-1.4	-1.0	-0.9
Worry (Nagel 2018)	0.8	1.7	5.7	2.4	1.1	0.8	0.8	0.6
Allergy or Eczema	0.8	2.2	5.4	0.8	-0.7	1.8	1.0	2.3
Supplements: Zinc	0.8	0.9	1.3	0.9	0.6	0.9	1.1	1.0
Current tobacco smoking	0.8	1.3	3.0	-0.9	-0.7	-0.9	-1.3	-1.7
Maternal smoking around birth	0.8	1.2	1.8	-1.3	-0.6	-1.3	-1.1	-1.0
Waist circumference	0.8	3.1	5.4	-2.3	-1.0	-1.7	-1.6	-1.8
Pulse rate	0.8	1.4	2.3	-1.3	-0.8	-1.1	-1.1	-1.5
Blood clot in the leg (DVT)	0.8	1.1	1.7	0.2	1.3	0.7	1.3	1.2
Gout (self-reported)	0.8	1.1	2.2	-0.8	-1.5	-1.2	-0.9	-0.7
Health satisfaction	0.8	1.0	1.9	-1.3	-0.3	-1.4	-0.9	-0.8
Commuting to job workplace: Car/motor vehicle	0.8	1.0	1.8	-1.3	-0.9	-0.8	-0.9	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	2.0	0.2	0.6	-1.0	-0.9	-1.4
Smoking status: Current	0.8	1.2	2.9	-0.8	-0.4	-1.0	-1.2	-1.7
Diastolic blood pressure, automated reading	0.8	2.6	3.1	-1.6	-1.6	-1.8	-1.7	-1.4
Commuting to job workplace: Cycle	0.8	1.0	1.8	0.2	0.7	1.0	1.3	1.3
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-0.8	-0.8	-1.2	-0.8	-0.6
Respiratory disease	0.7	1.5	3.3	1.4	0.3	1.8	0.9	1.1
Ever had hysterectomy (womb removed)	0.7	0.8	2.6	-0.3	1.6	0.7	0.9	0.4
Pain all over the body in last month	0.7	0.8	1.3	-1.0	-1.0	-0.7	-1.1	-0.3
Hair/balding pattern: Pattern 3	0.7	1.1	1.6	-1.0	-1.3	-0.0	-1.2	-1.1
Happiness	0.7	0.8	1.2	-0.7	-0.5	-1.1	-1.1	-1.0
Prospective memory result	0.7	0.9	2.4	1.1	-0.0	0.6	0.8	1.6
Body fat percentage	0.7	2.6	5.2	-2.3	-1.7	-1.5	-1.3	-1.0
Illnesses of father: Heart disease	0.7	1.0	2.0	-1.1	-1.1	-1.4	-0.7	-0.4
Commuting to job workplace: Public transport	0.7	0.9	2.3	0.7	0.8	1.5	0.7	0.7
Basal cell carcinoma (self-reported)	0.7	0.9	1.8	0.1	1.4	-0.4	1.3	0.8
Leg fat mass (left)	0.7	2.8	5.6	-2.4	-1.2	-1.8	-1.5	-1.4
Crohns Disease (2017)	0.6	1.4	3.0	0.3	-1.4	1.7	-0.2	1.3
Bipolar Disorder (2011)	0.6	0.5	2.1	0.7	0.0	-1.4	-0.5	0.0
LDL Cholesterol	0.6	0.9	3.1	0.6	1.8	0.9	0.6	0.2
Lung FEV1/FVC ratio	0.6	3.1	5.8	-2.3	-0.5	-2.4	-1.4	-1.5
Pack years adult smoking proportion	0.6	0.9	1.3	-1.1	0.3	-1.1	-0.7	-1.1
Diabetes (self-reported)	0.6	0.9	1.4	-0.6	1.0	-1.1	-0.4	-1.2
Medication: Simvastatin	0.6	0.9	1.5	-0.6	1.2	-0.9	-0.7	-1.1
Arm fat mass (right)	0.6	2.4	4.7	-2.2	-1.5	-1.6	-1.2	-1.1
Medication: Seretide 50 evohaler	0.6	0.7	1.6	1.3	0.8	1.0	0.5	0.4
Chest pain or discomfort	0.6	0.8	1.3	-1.1	-0.5	-1.1	-1.0	-0.5
Loneliness, isolation	0.6	0.9	1.5	1.2	1.1	0.3	0.8	0.9
Diabetes diagnosed by doctor	0.6	1.0	2.0	-0.8	0.3	-1.2	-0.7	-1.4
Medication for cholesterol	0.6	0.9	2.0	1.4	0.3	1.0	0.9	0.9
Unable to work because of sickness or disability	0.6	0.8	2.6	1.0	-0.5	1.6	-0.1	0.6
Reaction Time	0.5	0.9	2.0	-0.4	0.8	1.1	0.8	1.4
Mean Putamen Volume	0.5	0.6	1.1	0.7	-0.1	-1.1	-0.6	-0.9
Neuroticism (2016)	0.5	0.7	1.3	-0.6	-1.1	-0.4	-0.8	-1.0
Rheumatoid Arthritis	0.5	0.7	2.2	-1.5	-0.6	-0.3	-0.7	-0.6
Relative age voice broke	0.5	0.8	1.8	1.3	0.4	1.0	0.8	0.7
Stomach or abdominal pain in last month	0.5	0.6	0.8	0.7	0.9	0.8	0.7	0.6
Hip circumference	0.5	2.0	5.0	-2.2	-0.8	-1.3	-1.0	-1.3
Noisy workplace	0.5	0.6	1.5	-0.5	-0.6	-1.2	-0.7	-0.6
Exposure to tobacco smoke at home	0.5	0.6	1.1	1.0	1.0	0.6	0.9	-0.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	3.1	-1.8	-0.5	-0.6	-0.9	-0.7
Eye problems/disorders: None of the above	0.5	0.6	1.5	0.2	-1.0	-0.2	0.4	1.2
Whole body fat mass	0.5	2.0	4.8	-2.2	-1.2	-1.3	-1.2	-0.9
Handedness (chirality/laterality): Left-handed	0.5	0.6	2.3	0.1	1.5	-0.3	0.5	-0.6
Eye problems/disorders: Cataract	0.5	0.6	2.2	-0.0	0.0	1.5	0.5	0.7
Arm fat mass (left)	0.5	2.1	4.0	-2.0	-1.3	-1.6	-1.1	-0.9
Wears glasses or contact lenses	0.5	0.6	1.6	0.0	-0.8	-1.3	-0.7	-0.2
Illnesses of father: High blood pressure	0.5	0.7	1.1	-0.6	-0.4	-1.1	-0.8	-0.9
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.5	-0.3	1.6	-0.0	0.7	0.3
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.3	1.0	0.3	1.8	1.0	1.1
Pain experienced in last month	0.5	0.8	1.4	0.8	1.2	1.1	0.6	0.4
Pack years of smoking	0.5	0.7	1.0	-1.0	0.4	-1.0	-0.6	-1.0
Systolic blood pressure, automated reading	0.4	1.2	1.6	-1.3	-0.7	-1.2	-1.2	-1.1
Trunk fat percentage	0.4	1.8	4.0	-2.0	-1.6	-1.1	-1.0	-0.5
Supplements: Glucosamine	0.4	0.6	2.3	-1.5	-0.4	-0.7	-0.1	-0.1
Medication: Levothyroxine sodium	0.4	0.6	2.3	-1.5	-0.2	-0.6	-0.6	-0.5
Neuroticism score	0.4	0.8	2.0	1.4	1.2	0.5	0.6	0.2
Weight	0.4	2.0	4.2	-2.1	-0.9	-1.6	-1.2	-1.0
Arm fat percentage (right)	0.4	1.5	3.2	-1.8	-1.6	-1.0	-0.9	-0.6
Medication: Lansoprazole	0.4	0.4	1.0	-0.7	-0.1	-1.0	-0.6	-0.5
Length of working week for main job	0.4	0.4	0.7	-0.7	-0.1	-0.7	-0.6	-0.8
Medication: Paracetamol	0.4	0.6	1.3	1.0	1.1	0.4	0.5	-0.4
Wheeze or whistling in the chest in last year	0.4	0.7	1.4	0.8	-0.0	0.9	0.6	1.2
Qualifications: College or University degree	0.4	1.4	2.7	0.1	0.6	1.6	1.3	1.4
Neck or shoulder pain in last month	0.4	0.6	2.0	0.2	-0.1	0.5	1.0	1.4
Medication: Allopurinol	0.4	0.5	1.2	-0.9	-1.1	-0.5	-0.4	-0.2
Age at last live birth	0.4	0.6	1.7	1.3	0.2	-0.0	0.5	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	1.2	-0.8	-1.1	-0.3	-0.5	0.1
Smoking status: Previous	0.4	0.5	1.0	0.5	0.6	1.0	0.7	0.8
Medication: Aspirin	0.4	0.5	1.2	0.4	1.1	0.7	0.6	0.3
High cholesterol (Self-reported)	0.4	0.8	2.0	-0.7	-0.5	-1.4	-0.8	-0.8
Heart disease (siblings)	0.4	0.5	1.1	-0.9	-1.0	-0.8	-0.4	0.1
Impedance of whole body	0.4	2.3	5.0	1.1	0.2	2.2	1.3	1.8
Depressed Affect (Nagel 2018)	0.3	0.6	1.6	0.1	-0.1	-1.3	-0.7	-0.8
Depression (Nagel 2018)	0.3	0.4	0.7	0.2	-0.7	-0.8	-0.7	-0.6
Schizophrenia vs Biploar Disorder	0.3	0.3	0.7	-0.8	0.5	-0.1	-0.6	-0.6
Ovarian Cancer	0.3	0.4	1.1	-0.6	1.0	-0.3	-0.1	-0.5
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.4	0.4	1.6	-0.2	0.6	-0.2
Average weekly spirits intake	0.3	0.4	0.8	0.5	-0.7	-0.9	-0.6	-0.4
Relative age of first facial hair	0.3	0.6	1.5	1.2	0.3	0.6	0.5	1.0
Diabetes (father)	0.3	0.4	1.7	-0.0	-0.4	-1.3	-0.1	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	0.9	1.0	0.7	-0.3	0.5	0.0
Trunk fat mass	0.3	1.4	3.6	-1.9	-1.1	-1.0	-0.9	-0.6
Number of incorrect matches in round	0.3	0.4	1.3	-0.7	-1.1	0.4	-0.3	0.4
Mouth/teeth dental problems	0.3	0.5	1.3	0.9	0.1	-0.3	0.4	1.1
Heart attack	0.3	0.3	1.3	-0.1	0.4	-1.1	-0.4	-0.3
Number of live births	0.3	0.4	1.2	-0.2	0.4	1.1	0.7	0.5
Birth weight of first child	0.3	0.5	1.2	0.7	-1.1	0.5	0.1	0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.6	0.8	-0.4	0.7	0.5	0.6
Glaucoma (self-reported)	0.3	0.4	1.1	-1.1	-0.1	-0.5	-0.3	-0.7
Forced vital capacity (FVC), Best measure	0.3	0.9	1.4	1.1	0.8	1.2	1.0	0.7
Comparative body size at age 10	0.3	0.9	1.9	-1.3	0.0	-0.6	-0.6	-1.4
Medication for pain relief, constipation, heartburn	0.3	0.5	1.5	0.1	-0.3	0.8	0.4	1.2
Heart disease (mother)	0.3	0.3	0.6	-0.5	-0.5	-0.8	-0.4	-0.5
Illnesses of siblings: Diabetes	0.3	0.4	1.1	-0.4	-0.6	-1.0	0.3	0.6
Arm fat percentage (left)	0.3	1.2	2.5	-1.6	-1.3	-1.0	-0.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	-0.9	-0.2	0.5	-0.3	-0.9
Mineral and other dietary supplements	0.3	0.4	0.8	0.5	-0.1	0.9	0.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.2	-0.9	0.3	-1.0	-0.4	-1.1
Hearing aid user	0.3	0.4	0.9	-0.2	-0.2	-1.0	-0.4	-0.8
Medication: Paracetamol	0.3	0.4	1.0	0.9	1.0	0.1	0.1	-0.5
Arm fat-free mass (left)	0.3	1.4	2.1	-1.5	-0.6	-1.4	-1.1	-1.3
Average weekly beer plus cider intake	0.3	0.4	1.3	0.3	-0.1	-0.0	-0.6	-1.2
Risk taking	0.3	0.5	1.4	-0.4	-0.1	-0.8	-0.6	-1.2
Fractured/broken bones in last 5 years	0.3	0.4	1.2	-0.4	-1.1	-0.1	-0.5	-0.5
Myopia	0.3	0.5	2.0	-0.1	-0.2	-0.2	0.5	1.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.5	0.2	0.5	-1.2	-0.2	-0.2
Alcohol drinker status: Previous	0.3	0.3	1.0	1.0	0.4	0.5	0.2	0.2
Arm predicted mass (left)	0.3	1.3	2.2	-1.3	-0.5	-1.5	-1.0	-1.2
Bipolar Disorder (2018)	0.2	0.3	0.6	-0.6	-0.8	-0.6	-0.1	-0.0
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.8	-0.5	-0.9	-0.6	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	1.0	1.1	-0.1	0.6	0.2
Age at First Birth	0.2	0.3	0.7	-0.2	-0.0	0.3	0.8	0.8
Crohns Disease (2012)	0.2	0.3	0.8	0.0	0.0	0.9	-0.6	0.6
HDL Cholesterol	0.2	0.3	0.4	0.5	-0.7	0.6	0.4	0.4
Blood Red Count	0.2	1.9	4.7	-1.6	-2.2	1.2	-0.7	0.6
Blood White Count	0.2	1.8	3.2	0.3	-1.6	1.7	0.6	1.8
Heel T-Score	0.2	1.5	3.5	-0.5	-1.3	-1.9	-1.0	-1.1
Systolic Blood Pressure	0.2	1.2	1.7	-0.9	-0.9	-1.3	-1.2	-1.0
Smoking Status	0.2	0.4	1.3	-0.4	0.2	-0.5	-0.6	-1.2
Neuroticism	0.2	0.4	0.7	0.8	0.4	-0.6	-0.5	-0.7
Tanning	0.2	2.5	3.3	-1.8	-1.6	-1.4	-1.4	-1.6
Sensitivity / hurt feelings	0.2	0.3	0.8	0.3	0.1	-0.5	-0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	-0.3	-0.3	0.7	0.1	0.6
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.5	-0.2	-0.7	-0.4	-0.6	-0.3
Diabetes (mother)	0.2	0.2	0.7	-0.0	0.2	0.8	0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.7	-0.1	-0.4	-0.4	-0.5
Taking other prescription medications	0.2	0.3	1.1	-1.1	-0.3	-0.2	-0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.3	0.5	0.4	0.5	0.6
Hearing difficulty/problems with background noise	0.2	0.3	0.5	0.1	-0.5	-0.6	0.4	0.7
Qualifications: None of the above	0.2	0.3	0.4	-0.1	-0.6	-0.6	-0.6	-0.7
Fluid intelligence score	0.2	0.5	0.8	0.7	0.9	0.7	0.7	0.3
Medication: Cholesterol lowering	0.2	0.3	1.0	0.1	1.0	-0.4	0.1	-0.4
Depression (self-reported)	0.2	0.2	0.5	-0.2	0.7	0.7	0.4	0.2
Standing height	0.2	2.2	3.0	1.0	1.5	1.7	1.4	1.7
Loud music exposure frequency	0.2	0.3	0.9	0.4	0.2	-0.5	-0.2	-0.9
Headache pain in last month	0.2	0.4	1.2	0.5	-0.2	0.3	0.5	1.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	0.0	-1.1	0.2	-0.3	0.3
Worry too long after embarrassment	0.2	0.3	0.4	0.7	0.5	0.4	0.6	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	-0.2	-0.6	0.4	-0.6	-0.2
Medication: Blood pressure	0.2	0.4	0.6	-0.7	0.2	-0.7	-0.5	-0.8
Medication: Ibuprofen	0.2	0.2	0.9	0.0	0.5	-0.0	-0.3	-1.0
Mean time to correctly identify matches	0.2	0.3	0.8	-0.9	0.5	0.1	0.1	0.7
Suffer from ‘nerves’	0.2	0.4	0.9	0.9	0.6	0.7	0.2	-0.3
Had major operations	0.2	0.3	0.6	0.6	0.1	0.1	0.8	0.6
Family relationship satisfaction	0.2	0.2	0.3	-0.5	0.6	-0.5	-0.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.2	0.0	0.1	1.1	0.6	0.5
Ever had bowel cancer screening	0.2	0.2	0.5	0.2	0.7	0.4	0.4	0.6
Breast cancer (self-reported)	0.2	0.2	0.7	0.3	-0.2	-0.8	-0.3	-0.1
Medication: Atorvastatin	0.2	0.3	0.6	-0.8	-0.2	-0.5	0.1	-0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	0.6	0.7	0.4	0.6	0.1
Prostate Cancer	0.1	0.2	0.6	-0.4	-0.8	0.0	-0.3	-0.2
Coronary Artery Disease (CAD)	0.1	0.2	0.5	-0.2	0.5	-0.1	0.2	-0.7
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.2	0.4	0.0	0.3	-0.3
BMI	0.1	0.6	1.7	-0.6	-0.4	-1.3	-0.6	-0.7
Waist Hip Ratio (WHR)	0.1	0.6	1.0	-0.8	-0.2	-0.7	-1.0	-0.9
Cardiovascular Disease	0.1	0.4	1.3	0.1	0.6	-1.1	0.4	0.0
Lung FVC	0.1	0.3	1.4	0.1	0.3	-0.0	0.0	-1.2
Chronotype (morning person)	0.1	0.3	0.6	-0.8	-0.7	0.1	-0.7	0.1
Number of treatments/medications taken	0.1	0.2	0.7	0.2	0.8	0.2	0.2	-0.1
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.6	-0.2	-0.4	-0.4	-0.3
Impedance of leg (right)	0.1	0.3	1.3	0.3	-0.2	1.1	0.2	0.2
Hand grip strength (right)	0.1	0.3	0.6	-0.3	-0.8	-0.0	-0.6	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.3	-0.1	-0.6	-0.2	-0.7
Age when periods started (menarche)	0.1	0.2	0.3	-0.3	-0.3	0.3	0.4	0.6
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	0.3	-0.3	-0.1	0.1
Medication: Atenolol	0.1	0.1	0.2	-0.2	0.3	-0.3	-0.0	-0.4
Impedance of leg (left)	0.1	0.6	2.1	0.5	0.1	1.4	0.5	0.5
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.3	0.6	-0.3	0.0	-0.3
Forced vital capacity (FVC)	0.1	0.4	1.0	0.5	0.5	1.0	0.7	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.1	0.4	-0.6	0.3	0.5	0.1	-0.1
Financial difficulties in last 2 years	0.1	0.1	0.3	-0.2	0.3	0.0	-0.3	-0.6
Medication: Ramipril	0.1	0.2	0.6	-0.8	-0.2	0.4	-0.2	-0.3
Illnesses of siblings	0.1	0.2	0.5	0.5	0.1	0.7	-0.1	-0.2
Trunk fat-free mass	0.1	0.3	0.7	-0.4	0.3	-0.8	-0.4	-0.7
Time employed in main current job	0.1	0.1	0.4	0.6	0.1	0.4	-0.1	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.6	0.7	0.1	0.2	0.2	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.8	-0.2	0.2	-0.2	-0.1	-0.9
Lung cancer (father)	0.1	0.1	0.3	-0.0	-0.5	-0.2	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.4	-0.4	-0.3	-0.6	-0.5	-0.6
Trunk predicted mass	0.1	0.3	0.6	-0.5	0.3	-0.8	-0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.3	0.2	-0.7	-0.2	-0.0
Hair/balding pattern: Pattern 4	0.1	0.3	0.9	-0.3	0.5	-1.0	-0.2	-0.7
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.2	0.0	0.6	0.6	0.8
High blood pressure (siblings)	0.1	0.2	0.8	-0.1	0.9	-0.2	0.3	-0.1
Arm fat-free mass (right)	0.1	0.4	1.0	-0.7	0.2	-1.0	-0.5	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.5	-0.1	0.7	-0.3	-0.1	-0.5
Arm predicted mass (right)	0.1	0.3	0.8	-0.5	0.3	-0.9	-0.4	-0.5
Pulse rate, automated reading	0.1	0.3	0.7	-0.7	-0.4	-0.4	-0.4	-0.8
Alcohol intake frequency.	0.1	0.3	1.2	-0.4	1.1	-0.4	0.2	-0.1
Medication: Aspirin	0.1	0.2	0.3	0.2	0.4	0.6	0.4	0.2
Knee pain experienced in last month	0.1	0.2	0.6	0.4	-0.1	-0.5	0.3	0.7
Mood swings	0.1	0.3	0.6	0.5	-0.3	-0.8	-0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.3	-0.5	-0.0	0.5	0.4	0.4
Osteoarthritis (self-reported)	0.1	0.1	0.1	0.3	0.1	0.2	-0.3	-0.4
Miserableness	0.1	0.1	0.3	-0.1	0.6	-0.1	-0.1	-0.5
Guilty feelings	0.1	0.1	0.3	-0.2	-0.3	-0.6	-0.4	-0.4
Financial situation satisfaction	0.1	0.1	0.2	-0.1	-0.2	0.4	-0.5	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	-0.1	0.5	0.2	0.3	0.1
Ever smoked	0.1	0.2	0.3	0.2	-0.4	-0.4	-0.4	-0.5
Basal metabolic rate	0.1	0.5	1.0	-1.0	-0.2	-1.0	-0.5	-0.5
Number of operations (self-reported)	0.1	0.1	0.1	-0.2	0.4	-0.3	0.3	0.0
Age started oral contraceptive pill	0.1	0.1	0.6	-0.1	-0.1	0.8	0.1	0.2
Ever depressed for a whole week	0.1	0.1	0.2	-0.2	-0.5	-0.2	-0.3	0.4
Triglycerides	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1
Height	0.0	0.2	0.3	-0.3	-0.5	-0.3	-0.1	0.6
Hair Pigment	0.0	0.5	1.7	0.8	0.1	1.3	0.5	0.2
Hand grip strength (left)	0.0	0.1	0.2	0.3	-0.5	-0.1	0.0	0.1
Vitamin and mineral supplements	0.0	0.1	0.2	-0.4	-0.3	0.2	-0.0	-0.0
Leg fat-free mass (left)	0.0	0.2	0.5	-0.7	-0.2	-0.6	-0.3	-0.1
Fed-up feelings	0.0	0.1	0.2	0.5	0.3	-0.3	0.1	-0.0
Sitting height	0.0	0.1	0.1	-0.3	0.3	0.1	-0.1	0.3
Leg predicted mass (left)	0.0	0.2	0.4	-0.6	-0.2	-0.6	-0.2	-0.0
Past tobacco smoking	0.0	0.1	0.2	0.2	0.3	0.0	0.3	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.3	-0.6	-0.3	-0.3	-0.3	-0.4
Birth weight	0.0	0.1	0.3	-0.6	0.2	-0.3	-0.1	0.2
Number of full brothers	0.0	0.1	0.1	0.3	-0.4	-0.0	-0.1	0.2
Comparative height size at age 10	0.0	0.2	0.5	-0.1	0.4	0.7	0.5	0.5
Whole body fat-free mass	0.0	0.2	0.5	-0.5	0.2	-0.7	-0.3	-0.4
Leg fat-free mass (right)	0.0	0.1	0.2	-0.5	0.1	-0.3	0.0	0.2
Whole body water mass	0.0	0.2	0.6	-0.6	0.1	-0.7	-0.3	-0.4
Leg predicted mass (right)	0.0	0.1	0.2	-0.4	0.1	-0.3	0.1	0.3
Number of self-reported non-cancer illnesses	0.0	0.1	0.2	-0.3	-0.2	-0.5	-0.1	-0.0
Irritability	0.0	0.1	0.4	-0.1	-0.6	-0.1	-0.0	0.1
Supplements: Calcium	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.2

Hub : Genes

RLN2

Models

Trait associations