Hub : Genes

RNF141

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.320	0.0450	0.0e+00	0.235	0.267	0.287	0.295	0.297	2.9e-28	2.1e-32	3.9e-35	3.2e-36	1.5e-36
2	GTEx	Cells Transformed fibroblasts	0.142	0.0360	3.7e-07	0.080	NA	0.131	NA	0.126	1.3e-06	NA	4.8e-10	NA	1.2e-09
3	GTEx	Muscle Skeletal	0.113	0.0351	8.0e-05	0.026	NA	0.045	NA	0.046	1.4e-03	NA	2.7e-05	NA	2.2e-05
4	ROSMAP	Brain Pre-frontal Cortex	0.142	0.0344	2.5e-08	0.027	0.082	0.043	0.076	0.024	1.9e-04	1.0e-10	2.7e-06	4.6e-10	3.7e-04
5	YFS	Blood	0.190	0.0353	0.0e+00	0.045	0.090	0.099	0.091	0.073	1.3e-14	6.4e-28	8.7e-31	4.3e-28	1.0e-22

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	2.2	3.5	6.9	1.6	-2.6	2.4	1.3	0.5
Bipolar Disorder or Schizophrenia	1.9	4.6	7.7	2.2	-2.5	2.8	1.8	-0.9
Depressed Affect (Nagel 2018)	1.1	2.3	5.6	-1.6	2.4	-1.5	1.1	0.3
Depression (Nagel 2018)	0.8	1.3	1.7	-1.3	0.9	-1.0	1.2	1.1
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	0.0	0.7	-0.7	0.2	0.5
Neuroticism (Nagel 2018)	1.1	2.6	5.9	-1.8	2.4	-2.0	-0.1	-0.2
Schizophrenia (2018)	0.9	1.9	2.6	1.5	-1.1	1.6	1.2	-1.4
Schizophrenia vs Biploar Disorder	0.5	0.7	1.3	-1.1	0.4	-0.9	0.9	-0.4
Worry (Nagel 2018)	0.5	1.1	2.4	0.0	1.5	-0.9	0.1	-1.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.5	-0.5	0.6	-0.2	-0.7	-0.5
Alzheimer’s Disease (in father)	2.4	2.6	5.3	-2.0	1.8	-2.3	0.6	0.7
Alzheimer’s Disease (including proxy)	1.4	2.0	3.6	-1.7	1.9	-1.8	-0.3	0.5
Crohns Disease (2017)	0.3	0.6	1.5	-0.7	0.5	-0.7	-1.2	-0.5
Irritable Bowel Disease (IBD)	1.5	3.5	6.3	-2.5	1.8	-2.3	-1.4	1.0
Ulcerative Colitis (UC)	2.2	4.2	8.0	-2.8	1.8	-2.6	-1.0	1.5
Major Depression (MDD)	0.1	0.1	0.3	-0.3	-0.2	-0.1	0.3	0.5
Reaction Time	1.8	3.5	6.5	-2.5	2.2	-2.2	-0.8	0.6
Verbal and Numeric Reasoning (VNR)	0.8	2.0	3.5	-1.4	1.2	-1.9	-1.8	-0.1
Breast Cancer	0.1	0.3	0.5	0.5	0.4	-0.5	-0.7	0.1
Ovarian Cancer	0.3	0.4	1.2	0.5	-0.6	0.2	-0.1	-1.1
Prostate Cancer	0.3	0.5	1.2	-0.1	0.2	0.2	-1.1	-1.0
Age at First Birth	0.4	0.5	1.3	0.6	-0.5	0.9	-0.3	-1.1
Bipolar Disorder (2011)	1.5	1.5	2.7	0.8	-1.6	1.5	0.5	-1.2
Body Mass Index (BMI) (2010)	0.9	1.2	1.9	1.3	-1.0	1.4	1.2	0.3
Coronary Artery Disease (CAD)	1.6	1.9	3.0	1.6	-1.0	1.7	0.3	-1.7
Crohns Disease (2012)	0.3	0.5	1.7	-0.7	0.3	-0.5	-0.2	-1.3
Mean Putamen Volume	0.6	0.7	1.4	0.9	-0.6	1.2	-0.6	-0.7
Fasting Glucose	0.0	0.1	0.2	0.0	-0.5	0.1	-0.0	-0.2
HbA1C	0.2	0.2	0.6	0.8	-0.2	0.5	0.5	-0.0
HDL Cholesterol	1.1	1.8	4.7	0.8	-2.2	0.9	1.7	0.2
LDL Cholesterol	0.1	0.2	0.3	-0.4	0.5	-0.4	0.5	0.1
Lupus	0.5	0.7	2.0	-0.2	-1.4	0.3	-0.8	0.8
Neuroticism (2016)	0.8	1.1	3.6	-0.7	1.9	-0.8	-0.4	-0.8
Primary Biliary Cirrhosis	0.9	1.4	4.0	0.7	-0.2	1.5	-0.2	-2.0
Rheumatoid Arthritis	1.0	1.4	2.5	-0.3	1.5	-1.2	-1.6	-1.0
Schizophrenia (2014)	1.3	2.9	4.4	1.7	-1.7	2.1	1.5	-1.5
Triglycerides	0.4	0.6	1.8	-0.4	1.4	-0.8	0.5	-0.1
Type 2 Diabetes (T2D) (2012)	1.2	1.4	2.6	-1.6	1.0	-1.3	-0.6	1.2
Ulcerative Colitis	1.8	2.6	5.2	-2.3	1.6	-2.1	-0.2	0.9
Blood Eosinophil Count	0.1	1.1	3.0	0.5	-1.2	0.6	1.7	0.4
Blood Platelet Count	0.3	3.0	5.2	-1.5	1.5	-1.4	2.3	-1.9
Blood Red Count	0.5	4.7	7.1	1.9	-2.7	2.4	2.3	-1.2
Blood White Count	0.6	4.8	9.1	-2.8	2.6	-3.0	-0.5	0.6
Heel T-Score	0.8	6.1	17.0	-2.1	2.0	-2.0	-4.1	1.2
BMI	2.6	15.3	26.8	-4.7	3.2	-5.2	-1.6	3.8
Height	0.2	3.3	8.8	-1.9	-0.3	-1.4	-3.0	1.4
Waist Hip Ratio (WHR)	0.0	0.2	0.3	0.1	0.4	0.6	-0.1	-0.5
Systolic Blood Pressure	2.7	13.4	34.7	-2.3	4.3	-2.8	-5.9	0.6
Smoking Status	0.5	1.1	4.2	0.0	-0.9	0.2	0.5	2.0
Allergy or Eczema	0.3	0.8	1.9	1.4	-0.9	0.9	0.7	-0.3
Cardiovascular Disease	2.7	9.0	11.8	-3.4	3.4	-3.2	-3.0	1.6
Hypothyroidism (self reported)	1.4	3.1	5.8	2.3	-1.2	1.8	0.3	-2.4
Respiratory disease	0.9	2.0	7.7	-0.5	1.3	-0.5	-2.8	-0.5
Type 2 Diabetes (T2D) (2018)	4.6	8.7	12.4	-3.4	2.8	-3.5	-3.1	1.5
Lung FEV1/FVC ratio	0.5	2.6	5.3	-1.3	-1.3	-0.7	2.0	2.3
Lung FVC	1.2	5.9	10.0	2.6	-2.7	3.2	2.1	0.8
Neuroticism	0.5	1.3	3.6	-0.6	1.9	-0.8	0.1	-1.3
Chronotype (morning person)	0.5	1.1	3.3	-0.9	1.8	-0.6	-0.0	-1.0
Hair Pigment	0.0	0.3	0.7	0.4	0.0	0.6	0.8	0.6
Tanning	0.2	2.3	5.7	1.9	-0.5	1.3	2.4	-0.3
Hand grip strength (left)	0.8	2.0	4.5	-1.5	0.6	-1.2	-2.1	1.3
Number of treatments/medications taken	0.7	1.3	2.2	-1.1	1.5	-1.0	-1.4	0.1
Average weekly spirits intake	0.1	0.1	0.3	-0.0	0.6	-0.3	-0.5	0.3
Sensitivity / hurt feelings	0.1	0.3	0.6	-0.2	0.1	-0.4	0.6	-0.8
Frequency of depressed mood in last 2 weeks	1.1	1.6	2.5	-1.6	1.0	-1.3	1.4	0.9
Hearing difficulty/problems: Yes	1.3	1.9	4.2	-0.8	2.0	-1.2	-1.3	-1.3
Relative age of first facial hair	0.3	0.6	1.4	-0.2	0.2	-0.4	-1.2	-1.0
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.5	-0.1	0.4	-0.3	0.0	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	0.6	0.2	0.7	0.2	0.6
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	-0.0	0.8	0.7	-0.1	-1.0
Systolic blood pressure, automated reading	1.9	5.5	17.6	-1.1	2.4	-1.6	-4.2	-0.4
Eye problems/disorders: Diabetes related eye disease	2.0	2.2	3.5	-1.7	1.6	-1.3	-1.9	0.2
Angina	2.2	2.9	11.8	0.9	-1.2	0.5	0.6	-3.4
Medication for hormone replacement therapy	0.1	0.2	0.6	0.2	-0.2	0.3	-0.8	-0.1
Vitamin and mineral supplements	0.8	1.1	2.2	-0.8	1.2	-0.9	-1.5	-0.7
Supplements: Zinc	2.7	2.9	5.9	1.6	-2.4	2.2	1.1	0.3
Medication: Co-codamol	0.9	1.0	2.9	-0.4	-0.5	-0.3	1.3	1.7
Medication: Metformin	5.7	8.0	11.2	-3.3	2.5	-3.2	-2.6	2.5
Diabetes (father)	0.4	0.5	0.8	-0.0	-0.9	0.9	0.8	0.6
Diabetes (mother)	0.7	0.9	3.7	0.8	-0.0	0.1	0.1	-1.9
Severe depression (siblings)	0.3	0.3	0.9	-0.3	0.6	-0.4	-0.9	-0.2
Pack years adult smoking proportion	0.5	0.8	1.3	-0.8	1.1	-0.8	-0.4	-1.1
Impedance of leg (right)	0.2	1.2	2.2	0.7	-0.6	1.4	1.5	-0.9
Leg fat-free mass (left)	1.3	6.7	10.1	-2.9	1.9	-3.2	-2.7	2.0
Trunk fat percentage	1.3	5.2	8.2	-2.9	2.5	-2.9	-1.5	1.2
Hand grip strength (right)	0.9	2.3	4.7	-1.7	0.4	-0.9	-2.2	1.8
Townsend deprivation index at recruitment	0.8	1.1	2.1	1.3	-1.1	1.5	0.6	-0.3
Current tobacco smoking	1.2	1.9	5.8	0.0	-0.9	-0.0	1.8	2.4
Average weekly fortified wine intake	1.3	1.5	3.0	1.4	-1.7	1.1	1.0	-0.6
Maternal smoking around birth	0.3	0.4	1.0	0.2	0.0	-0.5	0.9	1.0
Fed-up feelings	0.8	1.4	2.6	-1.4	1.6	-1.1	0.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.3	0.7	-0.6	0.6	2.1	1.4
Relative age voice broke	0.3	0.4	0.9	0.3	-1.0	0.6	0.7	0.3
Taking other prescription medications	1.3	1.9	3.2	-1.0	1.7	-1.1	-1.8	-1.2
Age when periods started (menarche)	0.1	0.3	1.0	0.6	0.2	-0.1	1.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.1	-0.1	0.7	0.3	1.0	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.9	-1.1	0.5	-0.4	-1.7	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.6	-1.1	0.6	-1.3	0.3	-0.3
Qualifications: CSEs or equivalent	0.5	0.6	1.6	-0.0	0.2	0.5	-1.2	-1.2
Serious illness, injury or assault to yourself	1.0	1.2	2.9	-1.1	0.7	-1.1	-1.7	-0.7
High blood pressure	1.2	3.3	4.8	-1.8	1.9	-2.2	-2.0	0.9
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.6	1.3	-1.1	1.0	0.3	0.1
Multivitamins +/- minerals	0.7	0.9	1.8	-0.7	0.3	-0.6	1.4	1.2
Stomach or abdominal pain in last month	0.2	0.2	0.4	-0.6	-0.3	-0.7	-0.3	-0.4
Supplements: Glucosamine	1.0	1.2	4.8	0.4	-0.4	0.0	2.2	1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.0	0.5	-0.8	1.4	0.8	-0.7
Medication: Atenolol	0.5	0.6	0.8	0.9	-0.6	0.7	0.6	-0.9
Medication: Levothyroxine sodium	0.5	0.8	1.8	1.1	-0.1	0.4	-0.9	-1.3
Sitting height	0.4	3.2	4.4	-2.1	0.9	-2.1	-2.0	1.6
Chronic bronchitis/emphysema (father)	3.6	4.2	6.6	-2.1	2.6	-2.1	-2.3	0.8
High blood pressure (mother)	0.2	0.3	1.0	-0.1	-0.5	-0.2	-1.0	-0.3
Body mass index (BMI)	1.7	7.2	13.9	-3.3	2.5	-3.7	-1.7	1.4
Impedance of leg (left)	0.6	2.8	4.2	1.2	-1.2	2.0	2.1	-1.7
Leg predicted mass (left)	1.3	6.8	10.0	-2.9	1.9	-3.2	-2.8	2.1
Trunk fat mass	1.6	6.9	11.3	-3.2	2.6	-3.4	-2.0	1.4
Waist circumference	2.2	7.9	14.2	-3.4	2.9	-3.8	-2.0	1.1
Number of incorrect matches in round	1.0	1.7	3.4	1.8	-1.1	1.8	0.4	-0.8
Past tobacco smoking	1.4	2.6	4.8	1.7	-1.3	1.3	1.4	-2.2
Alcohol usually taken with meals	0.4	0.7	1.8	0.9	-1.3	0.8	0.2	-0.1
Nervous feelings	0.6	1.1	4.2	0.6	0.3	0.4	0.9	-2.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.2	-1.0	1.2	-0.8	1.5	0.8
Hearing difficulty/problems with background noise	2.4	3.9	7.3	-2.0	2.7	-2.5	-1.2	-0.0
Hair/balding pattern: Pattern 2	0.4	0.5	0.6	-0.6	0.5	-0.8	-0.8	0.6
Had menopause	0.5	0.6	2.1	1.0	-0.1	0.2	1.4	-0.2
Had other major operations	0.9	1.1	2.7	1.0	-1.6	1.4	-0.0	-0.4
Forced vital capacity (FVC)	0.9	3.5	6.2	1.1	-2.5	2.0	0.8	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	-0.7	0.0	-0.3	-1.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.3	0.7	-1.4	0.7	1.5	0.2
Qualifications: None of the above	0.1	0.3	0.5	0.6	0.3	0.3	0.6	-0.7
Financial difficulties in last 2 years	0.5	0.7	2.5	-0.5	-0.5	-0.6	-0.2	1.6
Mouth/teeth dental problems	2.6	3.9	6.0	2.5	-2.3	2.5	-0.6	-1.5
Heart attack	0.2	0.3	1.0	0.4	0.2	-0.2	1.0	-0.6
Allergy	0.5	1.2	2.7	-1.6	1.1	-1.4	-0.1	0.6
Pain all over the body in last month	1.1	1.2	4.2	-0.7	0.8	-0.6	-2.1	-0.1
Diabetes (self-reported)	5.1	7.9	11.6	-3.1	3.4	-3.4	-2.3	1.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.8	3.1	1.4	-1.8	1.6	0.7	-0.9
Medication: Ramipril	1.1	1.4	3.4	-1.3	1.2	-0.7	-1.8	-0.3
Medication: Simvastatin	1.3	2.0	3.9	-2.0	1.3	-1.5	-1.3	-0.2
Fluid intelligence score	0.4	0.9	1.9	-0.8	0.7	-1.4	-0.0	1.2
Illnesses of siblings	0.8	1.1	2.2	0.4	-1.5	1.5	0.8	-0.6
Neuroticism score	0.5	1.1	2.3	-0.1	1.0	-0.1	1.5	-1.5
Weight	2.0	9.7	16.5	-3.8	2.6	-4.1	-2.6	2.0
Impedance of arm (right)	0.6	2.6	7.9	1.9	-0.8	2.8	0.6	-0.7
Arm fat percentage (right)	1.2	4.7	7.4	-2.6	2.2	-2.7	-1.6	1.2
Trunk fat-free mass	0.7	4.1	7.1	-2.3	0.9	-2.7	-2.3	1.3
Hip circumference	2.5	10.9	19.1	-3.9	3.3	-4.4	-2.5	1.5
Time employed in main current job	0.4	0.4	0.9	0.7	0.2	1.0	-0.1	-0.8
Alcohol intake versus 10 years previously	0.7	1.0	2.8	0.6	-1.7	0.9	1.0	0.5
Father’s age at death	0.5	0.6	1.3	0.7	-1.1	0.8	-0.4	-0.8
Worrier / anxious feelings	0.9	1.6	3.6	-1.3	1.9	-1.6	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.3	-0.8	1.5	-0.5	0.3	0.5
Falls in the last year	0.2	0.2	0.5	-0.4	0.2	0.2	-0.7	-0.5
Hair/balding pattern: Pattern 3	0.5	0.8	3.3	-0.4	0.4	-0.5	0.2	1.8
Number of live births	0.4	0.5	0.9	-0.9	0.6	-1.0	0.5	0.4
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	7.7	0.9	-2.8	2.0	1.6	2.4
Pulse rate	0.6	1.0	2.1	1.0	-0.2	1.4	1.1	-0.6
Happiness	0.7	0.8	2.1	-1.4	0.7	-1.2	-0.3	-0.1
Noisy workplace	1.6	1.9	4.8	-0.6	1.5	-1.0	-1.2	-2.2
Qualifications: A levels/AS levels or equivalent	0.2	0.3	0.8	0.0	-0.9	0.5	0.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	-1.4	0.0	-1.0	-1.0	0.6
Mouth/teeth dental problems: Dentures	1.3	2.3	3.4	-1.8	1.5	-1.8	-0.4	1.5
Asthma	0.6	1.2	5.6	-0.2	0.2	-0.3	-2.4	-0.6
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.2	6.0	2.4	-1.6	2.2	2.4	-1.4
Medication: Cholesterol lowering	4.0	6.2	9.6	-2.9	3.0	-3.1	-1.6	1.0
Depression (self-reported)	1.5	1.8	2.5	-0.9	1.6	-1.0	-1.5	1.5
Medication: Lansoprazole	0.3	0.4	0.8	-0.2	0.3	-0.3	0.8	-0.9
Prospective memory result	0.5	0.6	1.5	0.8	-0.5	1.2	0.5	-0.6
Lung cancer (father)	0.1	0.1	0.6	0.1	-0.2	-0.2	0.8	0.1
Illnesses of mother	0.1	0.1	0.2	0.5	0.2	0.1	0.3	-0.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	6.7	1.6	-2.6	2.2	2.2	1.7
Pulse wave Arterial Stiffness index	0.2	0.3	0.6	0.8	-0.2	0.6	-0.4	-0.3
Impedance of arm (left)	0.6	2.9	8.4	2.2	-0.6	2.9	0.7	-0.7
Arm fat mass (right)	1.3	5.5	10.2	-2.9	2.1	-3.2	-1.5	1.5
Trunk predicted mass	0.7	4.0	7.1	-2.3	0.9	-2.7	-2.3	1.1
Standing height	0.2	1.5	3.2	-1.2	-0.0	-0.8	-1.8	1.6
Length of working week for main job	0.9	0.9	3.0	0.9	-0.1	0.5	-0.8	-1.7
Exposure to tobacco smoke at home	0.1	0.1	0.4	0.0	0.5	-0.1	0.1	0.6
Breastfed as a baby	2.6	3.2	9.0	1.3	-3.0	2.2	-0.1	-0.7
Tense / ‘highly strung’	0.7	1.2	2.5	-0.4	1.6	-1.0	1.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.6	2.4	3.9	-2.0	1.0	-1.9	-1.0	1.6
Hair/balding pattern: Pattern 4	0.5	1.3	2.1	1.2	-1.3	1.5	-0.0	-0.9
Birth weight of first child	0.8	1.5	2.9	0.9	-1.7	1.6	1.0	-0.4
Peak expiratory flow (PEF)	2.3	5.4	11.8	1.5	-3.4	3.0	1.8	0.9
Pulse wave reflection index	0.0	0.0	0.0	0.2	-0.0	-0.2	-0.2	0.1
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.3	-0.5	0.5	-0.1	-0.5	-0.4
Loud music exposure frequency	0.8	0.8	2.3	-0.0	0.3	-1.2	1.5	0.5
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	4.1	0.6	-1.4	1.1	2.0	0.7
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	-0.2	-0.2	0.0	0.1	-0.2
Blood clot in the leg (DVT)	0.2	0.2	0.4	-0.5	-0.6	0.2	-0.2	-0.6
Medication: Paracetamol	0.7	1.2	4.4	0.3	-0.9	0.7	2.1	-0.0
Headache pain in last month	0.7	1.2	2.3	-1.5	1.4	-1.3	-0.1	0.0
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	6.8	2.6	-2.6	2.5	1.6	-0.8
Glaucoma (self-reported)	0.5	0.5	1.9	0.0	-1.4	0.2	0.5	0.7
Gout (self-reported)	0.6	0.8	2.2	-0.5	1.3	-1.5	-0.4	-0.3
Hypothyroidism/myxoedema (self-reported)	1.0	1.9	3.7	1.9	-0.8	1.6	0.4	-1.7
Medication: Amlodipine	0.5	0.7	2.2	0.6	-0.2	0.4	1.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.0	-0.3	-0.0	-0.4	-0.5
Birth weight	0.9	2.0	4.7	0.4	-1.9	0.2	2.2	1.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.4	-0.8	1.0	-0.4	-1.5	0.0
High blood pressure (siblings)	1.0	1.4	3.2	-0.3	1.6	-1.8	-0.9	0.5
Forced vital capacity (FVC), Best measure	1.1	4.0	6.6	1.9	-2.6	2.3	1.4	1.5
Body fat percentage	1.3	5.1	8.9	-2.8	2.4	-3.0	-1.2	1.0
Leg fat percentage (right)	1.6	6.0	11.0	-3.1	2.5	-3.3	-1.2	1.1
Arm fat-free mass (right)	0.9	4.7	10.2	-2.7	1.3	-3.2	-1.8	1.0
Exposure to tobacco smoke outside home	0.9	1.3	2.3	-1.5	1.0	-1.1	-1.3	0.2
Comparative body size at age 10	0.4	1.1	2.1	-1.4	0.0	-0.9	-1.4	0.7
Number of full brothers	0.2	0.3	1.0	0.6	-0.2	0.0	-1.0	-0.3
Worry too long after embarrassment	0.8	1.3	6.4	0.1	0.1	0.2	0.3	-2.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.7	-0.4	0.5	-0.3	-1.0	-1.3
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	0.2	0.5	0.3	-0.9	-0.1
Number of children fathered	0.5	0.6	1.9	-0.6	0.4	-1.4	-0.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	0.4	-0.1	0.6	-0.2	0.0
Age at first live birth	0.4	0.6	1.4	0.8	-1.2	0.3	0.9	-0.5
Pulse wave peak to peak time	0.3	0.4	0.9	-0.9	0.1	-0.8	0.2	0.5
Health satisfaction	0.8	1.1	3.9	-0.6	0.5	-0.2	-0.9	-2.0
Shortness of breath walking on level ground	0.5	0.6	1.9	0.1	0.9	-0.3	-0.3	-1.4
Qualifications: College or University degree	0.3	0.9	1.8	-1.1	0.1	-1.2	-1.4	-0.2
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.6	-0.5	0.6	0.3	-0.1
Mouth/teeth dental problems: Loose teeth	2.1	2.5	3.9	-1.8	2.0	-1.7	-1.6	-0.0
Emphysema/chronic bronchitis	0.2	0.3	0.8	-0.4	0.2	-0.1	-0.9	0.6
Medication for pain relief, constipation, heartburn	0.6	1.0	4.1	-0.4	0.4	-0.1	-2.0	0.8
Neck or shoulder pain in last month	0.5	0.7	1.4	0.1	-0.4	0.9	-1.2	-1.0
Medication: Blood pressure	0.7	1.3	2.2	-1.3	1.4	-1.5	-0.2	-0.5
Angina (self-reported)	2.3	3.1	12.8	0.9	-1.0	0.6	0.5	-3.6
Migraine (self-reported)	0.5	0.6	2.5	-0.1	0.1	0.5	0.3	-1.6
Medication: Ibuprofen	3.5	4.2	7.3	2.5	-1.2	2.1	2.7	-1.3
Medication: Allopurinol	0.9	1.2	3.0	-0.8	1.5	-1.7	-0.5	-0.0
Medication: Omeprazole	0.5	0.6	1.4	-0.8	-0.4	-0.8	0.2	1.2
Medication: Seretide 50 evohaler	0.7	0.8	2.0	0.4	0.6	0.4	-1.4	-1.2
Mean time to correctly identify matches	1.8	3.5	6.0	-2.2	2.2	-2.5	-1.1	0.6
Heart disease (mother)	0.7	0.8	3.6	0.3	-0.3	0.6	1.9	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.0	-1.3	1.7	-1.1	-0.2	1.1
Whole body fat mass	1.7	7.2	12.5	-3.4	2.5	-3.5	-1.9	1.4
Leg fat mass (right)	2.0	7.8	14.4	-3.6	2.6	-3.8	-1.6	1.5
Arm predicted mass (right)	0.9	4.8	9.7	-2.8	1.3	-3.1	-1.8	1.1
Pulse rate, automated reading	0.1	0.3	0.4	-0.5	0.6	0.3	-0.4	-0.6
Alcohol intake frequency.	0.6	1.4	2.9	1.2	-0.9	1.0	0.8	-1.7
Comparative height size at age 10	0.2	0.9	3.5	-0.3	-0.2	0.1	-1.0	1.9
Number of full sisters	0.5	0.7	1.5	-1.0	1.2	-0.9	0.1	0.0
Suffer from ‘nerves’	0.4	0.7	1.4	0.9	0.3	0.8	1.2	-0.5
Overall health rating	1.0	2.2	3.4	-1.7	1.8	-1.9	-1.1	-0.2
Chest pain or discomfort	0.5	0.6	1.5	-1.0	1.2	-0.8	0.1	-0.5
Had major operations	0.4	0.5	1.6	-0.2	-0.9	0.1	-0.3	1.3
Age at last live birth	1.4	2.0	3.9	1.4	-1.7	0.9	2.0	-0.7
Family relationship satisfaction	1.8	2.2	2.5	-1.6	1.5	-1.4	-1.6	-1.3
Leg pain on walking	0.3	0.4	1.0	0.1	0.2	-0.6	1.0	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.9	0.8	-0.8	1.4	0.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.7	-0.9	0.9	-1.3	-0.3	-0.0
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.5	1.4	0.0	1.5	0.7	-1.9
Medication: Aspirin	1.3	1.7	3.0	-1.0	1.1	-1.4	-1.2	-1.7
Supplements: Vitamin C	4.0	4.8	7.1	2.4	-2.4	2.1	2.7	0.9
Knee pain experienced in last month	0.4	0.5	1.5	1.2	0.0	0.9	0.2	-0.6
Hypertension (Self-reported)	1.0	2.9	4.1	-1.7	1.8	-2.0	-1.7	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	0.2	0.7	0.4	-0.2	0.4
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.1	0.6	-0.0	0.9	1.0
Illnesses of siblings: Diabetes	0.5	0.6	2.3	0.1	0.1	-0.0	0.9	1.5
Smoking status: Previous	0.8	1.1	3.2	-0.9	0.8	-0.5	-1.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.8	0.2	-0.3	0.3	-0.4	0.9
Whole body fat-free mass	0.9	5.1	8.8	-2.6	1.3	-3.0	-2.4	1.4
Leg fat-free mass (right)	0.9	5.0	7.4	-2.6	1.5	-2.7	-2.5	1.6
Arm fat percentage (left)	1.2	4.7	7.4	-2.6	2.4	-2.7	-1.5	1.2
Average weekly red wine intake	0.6	0.9	1.6	-1.3	1.2	-1.3	0.1	-0.1
Handedness (chirality/laterality): Left-handed	7.3	8.8	14.0	-3.7	3.3	-3.2	-2.9	0.7
Mood swings	0.5	0.8	1.7	-1.3	1.1	-1.0	0.5	0.0
Loneliness, isolation	0.5	0.7	2.5	-0.0	0.6	0.3	0.8	-1.6
Long-standing illness, disability or infirmity	0.4	0.6	1.3	-0.5	0.9	-1.2	-0.6	-0.0
Ever had bowel cancer screening	3.2	3.7	9.5	1.9	-3.1	1.9	0.9	-0.9
Diabetes diagnosed by doctor	5.8	9.6	12.1	-3.4	3.2	-3.5	-3.0	2.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.8	-0.5	0.4	-0.6	-0.3	-0.9
Friendships satisfaction	1.7	2.1	3.9	-1.6	0.8	-2.0	-1.5	-1.0
Qualifications: nursing, teaching	0.4	0.7	1.6	-0.5	-0.2	-1.0	-1.3	0.7
Commuting to job workplace: Walk	1.5	1.6	2.8	1.7	-1.3	1.4	1.2	0.4
Eye problems/disorders: Cataract	0.0	0.0	0.1	0.0	-0.3	-0.1	-0.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	4.7	-1.9	2.2	-1.6	-0.3	1.0
Medication for cholesterol	0.3	0.5	1.2	-0.5	0.3	-0.6	1.1	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	3.6	-1.9	1.5	-1.9	-0.0	1.7
Back pain experienced in last month	0.3	0.4	0.6	-0.6	0.6	-0.6	0.8	-0.7
Mineral and other dietary supplements	2.0	2.6	4.5	-1.4	2.1	-1.4	-2.1	-0.1
Breast cancer (self-reported)	0.7	0.8	2.3	0.7	-1.5	0.8	-0.7	-0.1
Asthma (self-reported)	0.7	1.4	6.3	-0.3	0.3	-0.4	-2.5	-0.4
Osteoporosis (self-reported)	0.4	0.4	1.4	0.7	0.1	0.4	0.3	-1.2
Osteoarthritis (self-reported)	0.8	1.0	1.5	1.1	-0.6	0.8	1.2	1.2
Medication: Aspirin	1.6	2.1	2.7	-1.2	1.3	-1.6	-1.6	-1.4
Medication: Gliclazide	2.5	2.8	5.3	-1.8	1.3	-1.9	-0.1	2.3
Illnesses of father: None of the above (group 1)	1.4	1.7	4.8	0.7	-2.2	1.3	-0.1	-1.3
Smoking status: Current	1.4	2.3	8.0	-0.4	-0.5	-0.6	1.6	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.5	7.2	1.9	-2.7	2.0	2.7	-0.4
Whole body water mass	0.9	5.3	9.3	-2.7	1.3	-3.0	-2.5	1.4
Leg predicted mass (right)	1.0	5.2	7.7	-2.6	1.6	-2.8	-2.6	1.5
Arm fat mass (left)	1.5	6.0	10.5	-3.0	2.4	-3.2	-1.6	1.5
Number of self-reported non-cancer illnesses	2.0	3.4	4.9	-1.7	2.2	-2.2	-1.8	1.2
Average weekly champagne plus white wine intake	0.1	0.2	0.3	0.6	-0.2	0.3	-0.2	0.5
Miserableness	1.2	2.0	6.2	-0.2	0.7	0.1	1.8	2.5
Guilty feelings	1.4	2.1	4.0	-2.0	1.5	-1.7	-0.9	-0.7
Wears glasses or contact lenses	1.1	1.2	3.5	-0.9	1.9	-1.2	0.2	-0.5
Ever taken oral contraceptive pill	0.2	0.3	0.7	0.1	-0.4	0.7	-0.1	-0.8
Hearing aid user	0.3	0.3	1.2	1.1	0.5	0.4	0.1	-0.3
Mother’s age at death	0.6	0.8	1.5	0.5	-0.9	1.1	-1.2	0.4
Financial situation satisfaction	0.9	1.1	1.4	-1.2	1.1	-1.1	-0.6	-1.1
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.7	1.1	-0.8	1.6	0.0	-0.8
Commuting to job workplace: Public transport	0.4	0.5	1.0	0.4	-0.6	0.4	1.0	0.8
Eye problems/disorders: Glaucoma	0.4	0.4	1.1	0.5	-1.1	0.4	0.8	-0.1
Medication: Blood pressure	0.2	0.5	1.3	0.5	0.3	-0.0	-1.1	0.8
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.8	0.1	0.3	-0.6	-0.9	-1.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.1	0.9	-1.1	0.7	2.0	0.7
High cholesterol (Self-reported)	1.2	2.1	4.3	-1.7	1.5	-2.1	-1.0	-0.3
Medication: Bendroflumethiazide	0.7	1.1	4.0	-0.5	0.9	-0.7	0.4	2.0
Medication: Paracetamol	0.9	1.4	5.8	0.5	-0.4	0.7	2.4	-0.3
Medication: Lisinopril	0.5	0.6	1.2	-0.9	1.1	-0.8	-0.2	0.6
Medication: Atorvastatin	1.0	1.3	2.3	-1.5	0.7	-1.2	0.1	1.4
Illnesses of father: High blood pressure	0.5	0.7	1.2	-0.2	1.1	-0.6	-0.7	-1.1
Alcohol drinker status: Never	0.6	0.7	1.7	0.6	-1.0	0.5	0.5	-1.3
Ever smoked	0.9	1.6	4.7	-1.3	0.5	-0.7	-1.1	2.2
Basal metabolic rate	1.2	6.7	11.6	-3.1	1.7	-3.4	-2.6	1.7
Leg fat percentage (left)	1.4	4.9	9.6	-2.9	2.3	-3.1	-0.9	0.8
Arm fat-free mass (left)	1.3	6.4	12.5	-3.2	1.4	-3.5	-2.2	1.5
Number of operations (self-reported)	0.9	1.4	3.1	1.2	-1.7	1.4	-0.5	0.4
Average weekly beer plus cider intake	0.4	0.5	2.1	0.1	0.3	0.4	-1.5	-0.6
Irritability	0.2	0.3	0.5	-0.5	0.7	-0.6	-0.3	0.4
Risk taking	3.2	4.7	6.2	2.4	-2.4	2.2	2.5	-1.0
Ever had prostate specific antigen (PSA) test	2.6	3.0	5.2	-1.9	1.9	-1.4	-2.3	-0.8
Fractured/broken bones in last 5 years	1.1	1.4	3.4	1.2	-1.8	1.3	0.4	-0.1
Age started oral contraceptive pill	0.1	0.1	0.5	0.0	0.4	0.1	-0.7	-0.1
Diastolic blood pressure, automated reading	2.0	6.2	21.3	-0.8	2.4	-1.5	-4.6	-1.0
Ever depressed for a whole week	0.1	0.1	0.3	0.0	0.1	-0.3	-0.2	0.6
Unable to work because of sickness or disability	0.4	0.5	1.5	-0.2	1.2	-0.2	-0.9	0.4
Commuting to job workplace: Cycle	0.3	0.4	1.3	-0.1	-1.2	0.6	0.1	-0.3
Myopia	0.3	0.5	1.6	-0.0	-1.3	0.7	0.6	-0.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	3.4	1.5	-1.7	1.8	1.8	-0.0
Cholesterol lowering medication	0.2	0.3	0.6	-0.7	0.1	-0.5	-0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	3.0	-1.3	0.1	-1.2	-0.8	1.7
Pain experienced in last month	0.4	0.6	2.5	0.2	-0.7	0.2	0.3	1.6
Supplements: Calcium	1.4	1.5	2.5	1.2	-1.6	1.1	1.5	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.6	0.8	-0.2	0.4	0.1	-0.2
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	0.1	0.4	-0.4	0.8	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.6	-0.4	-0.4	0.0	-0.3	-0.8
Heart disease (siblings)	0.9	1.1	2.8	-0.8	1.7	-0.9	-0.9	0.5
Alcohol drinker status: Previous	1.1	1.3	3.3	-0.9	1.8	-1.1	-1.0	-0.1
Pack years of smoking	0.5	0.8	1.6	-0.7	1.3	-0.7	-0.5	-1.0
Impedance of whole body	0.6	3.2	7.4	1.9	-1.1	2.7	1.5	-1.3
Leg fat mass (left)	2.0	7.8	14.9	-3.6	2.6	-3.9	-1.6	1.2
Arm predicted mass (left)	1.3	6.4	12.8	-3.1	1.5	-3.6	-2.3	1.4