Hub : Genes

RNF141

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.320 0.0450 0.0e+00 0.235 0.267 0.287 0.295 0.297 2.9e-28 2.1e-32 3.9e-35 3.2e-36 1.5e-36
2 GTEx Cells Transformed fibroblasts 0.142 0.0360 3.7e-07 0.080 NA 0.131 NA 0.126 1.3e-06 NA 4.8e-10 NA 1.2e-09
3 GTEx Muscle Skeletal 0.113 0.0351 8.0e-05 0.026 NA 0.045 NA 0.046 1.4e-03 NA 2.7e-05 NA 2.2e-05
4 ROSMAP Brain Pre-frontal Cortex 0.142 0.0344 2.5e-08 0.027 0.082 0.043 0.076 0.024 1.9e-04 1.0e-10 2.7e-06 4.6e-10 3.7e-04
5 YFS Blood 0.190 0.0353 0.0e+00 0.045 0.090 0.099 0.091 0.073 1.3e-14 6.4e-28 8.7e-31 4.3e-28 1.0e-22

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 2.2 3.5 6.9 1.6 -2.6 2.4 1.3 0.5
Bipolar Disorder or Schizophrenia 1.9 4.6 7.7 2.2 -2.5 2.8 1.8 -0.9
Depressed Affect (Nagel 2018) 1.1 2.3 5.6 -1.6 2.4 -1.5 1.1 0.3
Depression (Nagel 2018) 0.8 1.3 1.7 -1.3 0.9 -1.0 1.2 1.1
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.6 0.0 0.7 -0.7 0.2 0.5
Neuroticism (Nagel 2018) 1.1 2.6 5.9 -1.8 2.4 -2.0 -0.1 -0.2
Schizophrenia (2018) 0.9 1.9 2.6 1.5 -1.1 1.6 1.2 -1.4
Schizophrenia vs Biploar Disorder 0.5 0.7 1.3 -1.1 0.4 -0.9 0.9 -0.4
Worry (Nagel 2018) 0.5 1.1 2.4 0.0 1.5 -0.9 0.1 -1.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.5 -0.5 0.6 -0.2 -0.7 -0.5
Alzheimer’s Disease (in father) 2.4 2.6 5.3 -2.0 1.8 -2.3 0.6 0.7
Alzheimer’s Disease (including proxy) 1.4 2.0 3.6 -1.7 1.9 -1.8 -0.3 0.5
Crohns Disease (2017) 0.3 0.6 1.5 -0.7 0.5 -0.7 -1.2 -0.5
Irritable Bowel Disease (IBD) 1.5 3.5 6.3 -2.5 1.8 -2.3 -1.4 1.0
Ulcerative Colitis (UC) 2.2 4.2 8.0 -2.8 1.8 -2.6 -1.0 1.5
Major Depression (MDD) 0.1 0.1 0.3 -0.3 -0.2 -0.1 0.3 0.5
Reaction Time 1.8 3.5 6.5 -2.5 2.2 -2.2 -0.8 0.6
Verbal and Numeric Reasoning (VNR) 0.8 2.0 3.5 -1.4 1.2 -1.9 -1.8 -0.1
Breast Cancer 0.1 0.3 0.5 0.5 0.4 -0.5 -0.7 0.1
Ovarian Cancer 0.3 0.4 1.2 0.5 -0.6 0.2 -0.1 -1.1
Prostate Cancer 0.3 0.5 1.2 -0.1 0.2 0.2 -1.1 -1.0
Age at First Birth 0.4 0.5 1.3 0.6 -0.5 0.9 -0.3 -1.1
Bipolar Disorder (2011) 1.5 1.5 2.7 0.8 -1.6 1.5 0.5 -1.2
Body Mass Index (BMI) (2010) 0.9 1.2 1.9 1.3 -1.0 1.4 1.2 0.3
Coronary Artery Disease (CAD) 1.6 1.9 3.0 1.6 -1.0 1.7 0.3 -1.7
Crohns Disease (2012) 0.3 0.5 1.7 -0.7 0.3 -0.5 -0.2 -1.3
Mean Putamen Volume 0.6 0.7 1.4 0.9 -0.6 1.2 -0.6 -0.7
Fasting Glucose 0.0 0.1 0.2 0.0 -0.5 0.1 -0.0 -0.2
HbA1C 0.2 0.2 0.6 0.8 -0.2 0.5 0.5 -0.0
HDL Cholesterol 1.1 1.8 4.7 0.8 -2.2 0.9 1.7 0.2
LDL Cholesterol 0.1 0.2 0.3 -0.4 0.5 -0.4 0.5 0.1
Lupus 0.5 0.7 2.0 -0.2 -1.4 0.3 -0.8 0.8
Neuroticism (2016) 0.8 1.1 3.6 -0.7 1.9 -0.8 -0.4 -0.8
Primary Biliary Cirrhosis 0.9 1.4 4.0 0.7 -0.2 1.5 -0.2 -2.0
Rheumatoid Arthritis 1.0 1.4 2.5 -0.3 1.5 -1.2 -1.6 -1.0
Schizophrenia (2014) 1.3 2.9 4.4 1.7 -1.7 2.1 1.5 -1.5
Triglycerides 0.4 0.6 1.8 -0.4 1.4 -0.8 0.5 -0.1
Type 2 Diabetes (T2D) (2012) 1.2 1.4 2.6 -1.6 1.0 -1.3 -0.6 1.2
Ulcerative Colitis 1.8 2.6 5.2 -2.3 1.6 -2.1 -0.2 0.9
Blood Eosinophil Count 0.1 1.1 3.0 0.5 -1.2 0.6 1.7 0.4
Blood Platelet Count 0.3 3.0 5.2 -1.5 1.5 -1.4 2.3 -1.9
Blood Red Count 0.5 4.7 7.1 1.9 -2.7 2.4 2.3 -1.2
Blood White Count 0.6 4.8 9.1 -2.8 2.6 -3.0 -0.5 0.6
Heel T-Score 0.8 6.1 17.0 -2.1 2.0 -2.0 -4.1 1.2
BMI 2.6 15.3 26.8 -4.7 3.2 -5.2 -1.6 3.8
Height 0.2 3.3 8.8 -1.9 -0.3 -1.4 -3.0 1.4
Waist Hip Ratio (WHR) 0.0 0.2 0.3 0.1 0.4 0.6 -0.1 -0.5
Systolic Blood Pressure 2.7 13.4 34.7 -2.3 4.3 -2.8 -5.9 0.6
Smoking Status 0.5 1.1 4.2 0.0 -0.9 0.2 0.5 2.0
Allergy or Eczema 0.3 0.8 1.9 1.4 -0.9 0.9 0.7 -0.3
Cardiovascular Disease 2.7 9.0 11.8 -3.4 3.4 -3.2 -3.0 1.6
Hypothyroidism (self reported) 1.4 3.1 5.8 2.3 -1.2 1.8 0.3 -2.4
Respiratory disease 0.9 2.0 7.7 -0.5 1.3 -0.5 -2.8 -0.5
Type 2 Diabetes (T2D) (2018) 4.6 8.7 12.4 -3.4 2.8 -3.5 -3.1 1.5
Lung FEV1/FVC ratio 0.5 2.6 5.3 -1.3 -1.3 -0.7 2.0 2.3
Lung FVC 1.2 5.9 10.0 2.6 -2.7 3.2 2.1 0.8
Neuroticism 0.5 1.3 3.6 -0.6 1.9 -0.8 0.1 -1.3
Chronotype (morning person) 0.5 1.1 3.3 -0.9 1.8 -0.6 -0.0 -1.0
Hair Pigment 0.0 0.3 0.7 0.4 0.0 0.6 0.8 0.6
Tanning 0.2 2.3 5.7 1.9 -0.5 1.3 2.4 -0.3
Hand grip strength (left) 0.8 2.0 4.5 -1.5 0.6 -1.2 -2.1 1.3
Number of treatments/medications taken 0.7 1.3 2.2 -1.1 1.5 -1.0 -1.4 0.1
Average weekly spirits intake 0.1 0.1 0.3 -0.0 0.6 -0.3 -0.5 0.3
Sensitivity / hurt feelings 0.1 0.3 0.6 -0.2 0.1 -0.4 0.6 -0.8
Frequency of depressed mood in last 2 weeks 1.1 1.6 2.5 -1.6 1.0 -1.3 1.4 0.9
Hearing difficulty/problems: Yes 1.3 1.9 4.2 -0.8 2.0 -1.2 -1.3 -1.3
Relative age of first facial hair 0.3 0.6 1.4 -0.2 0.2 -0.4 -1.2 -1.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.5 -0.1 0.4 -0.3 0.0 -0.7
Ever used hormone-replacement therapy (HRT) 0.2 0.3 0.5 0.6 0.2 0.7 0.2 0.6
Ever had hysterectomy (womb removed) 0.4 0.4 0.9 -0.0 0.8 0.7 -0.1 -1.0
Systolic blood pressure, automated reading 1.9 5.5 17.6 -1.1 2.4 -1.6 -4.2 -0.4
Eye problems/disorders: Diabetes related eye disease 2.0 2.2 3.5 -1.7 1.6 -1.3 -1.9 0.2
Angina 2.2 2.9 11.8 0.9 -1.2 0.5 0.6 -3.4
Medication for hormone replacement therapy 0.1 0.2 0.6 0.2 -0.2 0.3 -0.8 -0.1
Vitamin and mineral supplements 0.8 1.1 2.2 -0.8 1.2 -0.9 -1.5 -0.7
Supplements: Zinc 2.7 2.9 5.9 1.6 -2.4 2.2 1.1 0.3
Medication: Co-codamol 0.9 1.0 2.9 -0.4 -0.5 -0.3 1.3 1.7
Medication: Metformin 5.7 8.0 11.2 -3.3 2.5 -3.2 -2.6 2.5
Diabetes (father) 0.4 0.5 0.8 -0.0 -0.9 0.9 0.8 0.6
Diabetes (mother) 0.7 0.9 3.7 0.8 -0.0 0.1 0.1 -1.9
Severe depression (siblings) 0.3 0.3 0.9 -0.3 0.6 -0.4 -0.9 -0.2
Pack years adult smoking proportion 0.5 0.8 1.3 -0.8 1.1 -0.8 -0.4 -1.1
Impedance of leg (right) 0.2 1.2 2.2 0.7 -0.6 1.4 1.5 -0.9
Leg fat-free mass (left) 1.3 6.7 10.1 -2.9 1.9 -3.2 -2.7 2.0
Trunk fat percentage 1.3 5.2 8.2 -2.9 2.5 -2.9 -1.5 1.2
Hand grip strength (right) 0.9 2.3 4.7 -1.7 0.4 -0.9 -2.2 1.8
Townsend deprivation index at recruitment 0.8 1.1 2.1 1.3 -1.1 1.5 0.6 -0.3
Current tobacco smoking 1.2 1.9 5.8 0.0 -0.9 -0.0 1.8 2.4
Average weekly fortified wine intake 1.3 1.5 3.0 1.4 -1.7 1.1 1.0 -0.6
Maternal smoking around birth 0.3 0.4 1.0 0.2 0.0 -0.5 0.9 1.0
Fed-up feelings 0.8 1.4 2.6 -1.4 1.6 -1.1 0.3 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.5 4.3 0.7 -0.6 0.6 2.1 1.4
Relative age voice broke 0.3 0.4 0.9 0.3 -1.0 0.6 0.7 0.3
Taking other prescription medications 1.3 1.9 3.2 -1.0 1.7 -1.1 -1.8 -1.2
Age when periods started (menarche) 0.1 0.3 1.0 0.6 0.2 -0.1 1.0 -0.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 1.1 -0.1 0.7 0.3 1.0 -0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 2.9 -1.1 0.5 -0.4 -1.7 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.6 -1.1 0.6 -1.3 0.3 -0.3
Qualifications: CSEs or equivalent 0.5 0.6 1.6 -0.0 0.2 0.5 -1.2 -1.2
Serious illness, injury or assault to yourself 1.0 1.2 2.9 -1.1 0.7 -1.1 -1.7 -0.7
High blood pressure 1.2 3.3 4.8 -1.8 1.9 -2.2 -2.0 0.9
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.6 1.3 -1.1 1.0 0.3 0.1
Multivitamins +/- minerals 0.7 0.9 1.8 -0.7 0.3 -0.6 1.4 1.2
Stomach or abdominal pain in last month 0.2 0.2 0.4 -0.6 -0.3 -0.7 -0.3 -0.4
Supplements: Glucosamine 1.0 1.2 4.8 0.4 -0.4 0.0 2.2 1.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.0 0.5 -0.8 1.4 0.8 -0.7
Medication: Atenolol 0.5 0.6 0.8 0.9 -0.6 0.7 0.6 -0.9
Medication: Levothyroxine sodium 0.5 0.8 1.8 1.1 -0.1 0.4 -0.9 -1.3
Sitting height 0.4 3.2 4.4 -2.1 0.9 -2.1 -2.0 1.6
Chronic bronchitis/emphysema (father) 3.6 4.2 6.6 -2.1 2.6 -2.1 -2.3 0.8
High blood pressure (mother) 0.2 0.3 1.0 -0.1 -0.5 -0.2 -1.0 -0.3
Body mass index (BMI) 1.7 7.2 13.9 -3.3 2.5 -3.7 -1.7 1.4
Impedance of leg (left) 0.6 2.8 4.2 1.2 -1.2 2.0 2.1 -1.7
Leg predicted mass (left) 1.3 6.8 10.0 -2.9 1.9 -3.2 -2.8 2.1
Trunk fat mass 1.6 6.9 11.3 -3.2 2.6 -3.4 -2.0 1.4
Waist circumference 2.2 7.9 14.2 -3.4 2.9 -3.8 -2.0 1.1
Number of incorrect matches in round 1.0 1.7 3.4 1.8 -1.1 1.8 0.4 -0.8
Past tobacco smoking 1.4 2.6 4.8 1.7 -1.3 1.3 1.4 -2.2
Alcohol usually taken with meals 0.4 0.7 1.8 0.9 -1.3 0.8 0.2 -0.1
Nervous feelings 0.6 1.1 4.2 0.6 0.3 0.4 0.9 -2.1
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.2 -1.0 1.2 -0.8 1.5 0.8
Hearing difficulty/problems with background noise 2.4 3.9 7.3 -2.0 2.7 -2.5 -1.2 -0.0
Hair/balding pattern: Pattern 2 0.4 0.5 0.6 -0.6 0.5 -0.8 -0.8 0.6
Had menopause 0.5 0.6 2.1 1.0 -0.1 0.2 1.4 -0.2
Had other major operations 0.9 1.1 2.7 1.0 -1.6 1.4 -0.0 -0.4
Forced vital capacity (FVC) 0.9 3.5 6.2 1.1 -2.5 2.0 0.8 2.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.5 -0.7 0.0 -0.3 -1.2 0.7
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 2.3 0.7 -1.4 0.7 1.5 0.2
Qualifications: None of the above 0.1 0.3 0.5 0.6 0.3 0.3 0.6 -0.7
Financial difficulties in last 2 years 0.5 0.7 2.5 -0.5 -0.5 -0.6 -0.2 1.6
Mouth/teeth dental problems 2.6 3.9 6.0 2.5 -2.3 2.5 -0.6 -1.5
Heart attack 0.2 0.3 1.0 0.4 0.2 -0.2 1.0 -0.6
Allergy 0.5 1.2 2.7 -1.6 1.1 -1.4 -0.1 0.6
Pain all over the body in last month 1.1 1.2 4.2 -0.7 0.8 -0.6 -2.1 -0.1
Diabetes (self-reported) 5.1 7.9 11.6 -3.1 3.4 -3.4 -2.3 1.3
Hayfever/allergic rhinitis (self-reported) 1.3 1.8 3.1 1.4 -1.8 1.6 0.7 -0.9
Medication: Ramipril 1.1 1.4 3.4 -1.3 1.2 -0.7 -1.8 -0.3
Medication: Simvastatin 1.3 2.0 3.9 -2.0 1.3 -1.5 -1.3 -0.2
Fluid intelligence score 0.4 0.9 1.9 -0.8 0.7 -1.4 -0.0 1.2
Illnesses of siblings 0.8 1.1 2.2 0.4 -1.5 1.5 0.8 -0.6
Neuroticism score 0.5 1.1 2.3 -0.1 1.0 -0.1 1.5 -1.5
Weight 2.0 9.7 16.5 -3.8 2.6 -4.1 -2.6 2.0
Impedance of arm (right) 0.6 2.6 7.9 1.9 -0.8 2.8 0.6 -0.7
Arm fat percentage (right) 1.2 4.7 7.4 -2.6 2.2 -2.7 -1.6 1.2
Trunk fat-free mass 0.7 4.1 7.1 -2.3 0.9 -2.7 -2.3 1.3
Hip circumference 2.5 10.9 19.1 -3.9 3.3 -4.4 -2.5 1.5
Time employed in main current job 0.4 0.4 0.9 0.7 0.2 1.0 -0.1 -0.8
Alcohol intake versus 10 years previously 0.7 1.0 2.8 0.6 -1.7 0.9 1.0 0.5
Father’s age at death 0.5 0.6 1.3 0.7 -1.1 0.8 -0.4 -0.8
Worrier / anxious feelings 0.9 1.6 3.6 -1.3 1.9 -1.6 -0.2 -0.5
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.3 -0.8 1.5 -0.5 0.3 0.5
Falls in the last year 0.2 0.2 0.5 -0.4 0.2 0.2 -0.7 -0.5
Hair/balding pattern: Pattern 3 0.5 0.8 3.3 -0.4 0.4 -0.5 0.2 1.8
Number of live births 0.4 0.5 0.9 -0.9 0.6 -1.0 0.5 0.4
Forced expiratory volume in 1-second (FEV1) 1.2 4.2 7.7 0.9 -2.8 2.0 1.6 2.4
Pulse rate 0.6 1.0 2.1 1.0 -0.2 1.4 1.1 -0.6
Happiness 0.7 0.8 2.1 -1.4 0.7 -1.2 -0.3 -0.1
Noisy workplace 1.6 1.9 4.8 -0.6 1.5 -1.0 -1.2 -2.2
Qualifications: A levels/AS levels or equivalent 0.2 0.3 0.8 0.0 -0.9 0.5 0.5 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 1.8 -1.4 0.0 -1.0 -1.0 0.6
Mouth/teeth dental problems: Dentures 1.3 2.3 3.4 -1.8 1.5 -1.8 -0.4 1.5
Asthma 0.6 1.2 5.6 -0.2 0.2 -0.3 -2.4 -0.6
Medication: Ibuprofen (e.g. Nurofen) 3.3 4.2 6.0 2.4 -1.6 2.2 2.4 -1.4
Medication: Cholesterol lowering 4.0 6.2 9.6 -2.9 3.0 -3.1 -1.6 1.0
Depression (self-reported) 1.5 1.8 2.5 -0.9 1.6 -1.0 -1.5 1.5
Medication: Lansoprazole 0.3 0.4 0.8 -0.2 0.3 -0.3 0.8 -0.9
Prospective memory result 0.5 0.6 1.5 0.8 -0.5 1.2 0.5 -0.6
Lung cancer (father) 0.1 0.1 0.6 0.1 -0.2 -0.2 0.8 0.1
Illnesses of mother 0.1 0.1 0.2 0.5 0.2 0.1 0.3 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.4 6.7 1.6 -2.6 2.2 2.2 1.7
Pulse wave Arterial Stiffness index 0.2 0.3 0.6 0.8 -0.2 0.6 -0.4 -0.3
Impedance of arm (left) 0.6 2.9 8.4 2.2 -0.6 2.9 0.7 -0.7
Arm fat mass (right) 1.3 5.5 10.2 -2.9 2.1 -3.2 -1.5 1.5
Trunk predicted mass 0.7 4.0 7.1 -2.3 0.9 -2.7 -2.3 1.1
Standing height 0.2 1.5 3.2 -1.2 -0.0 -0.8 -1.8 1.6
Length of working week for main job 0.9 0.9 3.0 0.9 -0.1 0.5 -0.8 -1.7
Exposure to tobacco smoke at home 0.1 0.1 0.4 0.0 0.5 -0.1 0.1 0.6
Breastfed as a baby 2.6 3.2 9.0 1.3 -3.0 2.2 -0.1 -0.7
Tense / ‘highly strung’ 0.7 1.2 2.5 -0.4 1.6 -1.0 1.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 3.9 -2.0 1.0 -1.9 -1.0 1.6
Hair/balding pattern: Pattern 4 0.5 1.3 2.1 1.2 -1.3 1.5 -0.0 -0.9
Birth weight of first child 0.8 1.5 2.9 0.9 -1.7 1.6 1.0 -0.4
Peak expiratory flow (PEF) 2.3 5.4 11.8 1.5 -3.4 3.0 1.8 0.9
Pulse wave reflection index 0.0 0.0 0.0 0.2 -0.0 -0.2 -0.2 0.1
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.3 -0.5 0.5 -0.1 -0.5 -0.4
Loud music exposure frequency 0.8 0.8 2.3 -0.0 0.3 -1.2 1.5 0.5
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 4.1 0.6 -1.4 1.1 2.0 0.7
Mouth/teeth dental problems: Bleeding gums 0.0 0.0 0.1 -0.2 -0.2 0.0 0.1 -0.2
Blood clot in the leg (DVT) 0.2 0.2 0.4 -0.5 -0.6 0.2 -0.2 -0.6
Medication: Paracetamol 0.7 1.2 4.4 0.3 -0.9 0.7 2.1 -0.0
Headache pain in last month 0.7 1.2 2.3 -1.5 1.4 -1.3 -0.1 0.0
Medication for cholesterol, blood pressure or diabetes 2.7 4.5 6.8 2.6 -2.6 2.5 1.6 -0.8
Glaucoma (self-reported) 0.5 0.5 1.9 0.0 -1.4 0.2 0.5 0.7
Gout (self-reported) 0.6 0.8 2.2 -0.5 1.3 -1.5 -0.4 -0.3
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 3.7 1.9 -0.8 1.6 0.4 -1.7
Medication: Amlodipine 0.5 0.7 2.2 0.6 -0.2 0.4 1.5 -1.0
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 0.0 -0.3 -0.0 -0.4 -0.5
Birth weight 0.9 2.0 4.7 0.4 -1.9 0.2 2.2 1.4
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.4 -0.8 1.0 -0.4 -1.5 0.0
High blood pressure (siblings) 1.0 1.4 3.2 -0.3 1.6 -1.8 -0.9 0.5
Forced vital capacity (FVC), Best measure 1.1 4.0 6.6 1.9 -2.6 2.3 1.4 1.5
Body fat percentage 1.3 5.1 8.9 -2.8 2.4 -3.0 -1.2 1.0
Leg fat percentage (right) 1.6 6.0 11.0 -3.1 2.5 -3.3 -1.2 1.1
Arm fat-free mass (right) 0.9 4.7 10.2 -2.7 1.3 -3.2 -1.8 1.0
Exposure to tobacco smoke outside home 0.9 1.3 2.3 -1.5 1.0 -1.1 -1.3 0.2
Comparative body size at age 10 0.4 1.1 2.1 -1.4 0.0 -0.9 -1.4 0.7
Number of full brothers 0.2 0.3 1.0 0.6 -0.2 0.0 -1.0 -0.3
Worry too long after embarrassment 0.8 1.3 6.4 0.1 0.1 0.2 0.3 -2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.7 -0.4 0.5 -0.3 -1.0 -1.3
Wheeze or whistling in the chest in last year 0.1 0.2 0.8 0.2 0.5 0.3 -0.9 -0.1
Number of children fathered 0.5 0.6 1.9 -0.6 0.4 -1.4 -0.3 0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.4 0.4 -0.1 0.6 -0.2 0.0
Age at first live birth 0.4 0.6 1.4 0.8 -1.2 0.3 0.9 -0.5
Pulse wave peak to peak time 0.3 0.4 0.9 -0.9 0.1 -0.8 0.2 0.5
Health satisfaction 0.8 1.1 3.9 -0.6 0.5 -0.2 -0.9 -2.0
Shortness of breath walking on level ground 0.5 0.6 1.9 0.1 0.9 -0.3 -0.3 -1.4
Qualifications: College or University degree 0.3 0.9 1.8 -1.1 0.1 -1.2 -1.4 -0.2
Eye problems/disorders: None of the above 0.2 0.2 0.3 0.6 -0.5 0.6 0.3 -0.1
Mouth/teeth dental problems: Loose teeth 2.1 2.5 3.9 -1.8 2.0 -1.7 -1.6 -0.0
Emphysema/chronic bronchitis 0.2 0.3 0.8 -0.4 0.2 -0.1 -0.9 0.6
Medication for pain relief, constipation, heartburn 0.6 1.0 4.1 -0.4 0.4 -0.1 -2.0 0.8
Neck or shoulder pain in last month 0.5 0.7 1.4 0.1 -0.4 0.9 -1.2 -1.0
Medication: Blood pressure 0.7 1.3 2.2 -1.3 1.4 -1.5 -0.2 -0.5
Angina (self-reported) 2.3 3.1 12.8 0.9 -1.0 0.6 0.5 -3.6
Migraine (self-reported) 0.5 0.6 2.5 -0.1 0.1 0.5 0.3 -1.6
Medication: Ibuprofen 3.5 4.2 7.3 2.5 -1.2 2.1 2.7 -1.3
Medication: Allopurinol 0.9 1.2 3.0 -0.8 1.5 -1.7 -0.5 -0.0
Medication: Omeprazole 0.5 0.6 1.4 -0.8 -0.4 -0.8 0.2 1.2
Medication: Seretide 50 evohaler 0.7 0.8 2.0 0.4 0.6 0.4 -1.4 -1.2
Mean time to correctly identify matches 1.8 3.5 6.0 -2.2 2.2 -2.5 -1.1 0.6
Heart disease (mother) 0.7 0.8 3.6 0.3 -0.3 0.6 1.9 0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.4 3.0 -1.3 1.7 -1.1 -0.2 1.1
Whole body fat mass 1.7 7.2 12.5 -3.4 2.5 -3.5 -1.9 1.4
Leg fat mass (right) 2.0 7.8 14.4 -3.6 2.6 -3.8 -1.6 1.5
Arm predicted mass (right) 0.9 4.8 9.7 -2.8 1.3 -3.1 -1.8 1.1
Pulse rate, automated reading 0.1 0.3 0.4 -0.5 0.6 0.3 -0.4 -0.6
Alcohol intake frequency. 0.6 1.4 2.9 1.2 -0.9 1.0 0.8 -1.7
Comparative height size at age 10 0.2 0.9 3.5 -0.3 -0.2 0.1 -1.0 1.9
Number of full sisters 0.5 0.7 1.5 -1.0 1.2 -0.9 0.1 0.0
Suffer from ‘nerves’ 0.4 0.7 1.4 0.9 0.3 0.8 1.2 -0.5
Overall health rating 1.0 2.2 3.4 -1.7 1.8 -1.9 -1.1 -0.2
Chest pain or discomfort 0.5 0.6 1.5 -1.0 1.2 -0.8 0.1 -0.5
Had major operations 0.4 0.5 1.6 -0.2 -0.9 0.1 -0.3 1.3
Age at last live birth 1.4 2.0 3.9 1.4 -1.7 0.9 2.0 -0.7
Family relationship satisfaction 1.8 2.2 2.5 -1.6 1.5 -1.4 -1.6 -1.3
Leg pain on walking 0.3 0.4 1.0 0.1 0.2 -0.6 1.0 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.8 1.9 0.8 -0.8 1.4 0.6 -0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.7 -0.9 0.9 -1.3 -0.3 -0.0
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.5 1.4 0.0 1.5 0.7 -1.9
Medication: Aspirin 1.3 1.7 3.0 -1.0 1.1 -1.4 -1.2 -1.7
Supplements: Vitamin C 4.0 4.8 7.1 2.4 -2.4 2.1 2.7 0.9
Knee pain experienced in last month 0.4 0.5 1.5 1.2 0.0 0.9 0.2 -0.6
Hypertension (Self-reported) 1.0 2.9 4.1 -1.7 1.8 -2.0 -1.7 1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.2 0.5 0.2 0.7 0.4 -0.2 0.4
Illnesses of father: Heart disease 0.3 0.4 1.0 -0.1 0.6 -0.0 0.9 1.0
Illnesses of siblings: Diabetes 0.5 0.6 2.3 0.1 0.1 -0.0 0.9 1.5
Smoking status: Previous 0.8 1.1 3.2 -0.9 0.8 -0.5 -1.8 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.2 0.8 0.2 -0.3 0.3 -0.4 0.9
Whole body fat-free mass 0.9 5.1 8.8 -2.6 1.3 -3.0 -2.4 1.4
Leg fat-free mass (right) 0.9 5.0 7.4 -2.6 1.5 -2.7 -2.5 1.6
Arm fat percentage (left) 1.2 4.7 7.4 -2.6 2.4 -2.7 -1.5 1.2
Average weekly red wine intake 0.6 0.9 1.6 -1.3 1.2 -1.3 0.1 -0.1
Handedness (chirality/laterality): Left-handed 7.3 8.8 14.0 -3.7 3.3 -3.2 -2.9 0.7
Mood swings 0.5 0.8 1.7 -1.3 1.1 -1.0 0.5 0.0
Loneliness, isolation 0.5 0.7 2.5 -0.0 0.6 0.3 0.8 -1.6
Long-standing illness, disability or infirmity 0.4 0.6 1.3 -0.5 0.9 -1.2 -0.6 -0.0
Ever had bowel cancer screening 3.2 3.7 9.5 1.9 -3.1 1.9 0.9 -0.9
Diabetes diagnosed by doctor 5.8 9.6 12.1 -3.4 3.2 -3.5 -3.0 2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.8 -0.5 0.4 -0.6 -0.3 -0.9
Friendships satisfaction 1.7 2.1 3.9 -1.6 0.8 -2.0 -1.5 -1.0
Qualifications: nursing, teaching 0.4 0.7 1.6 -0.5 -0.2 -1.0 -1.3 0.7
Commuting to job workplace: Walk 1.5 1.6 2.8 1.7 -1.3 1.4 1.2 0.4
Eye problems/disorders: Cataract 0.0 0.0 0.1 0.0 -0.3 -0.1 -0.0 -0.1
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 4.7 -1.9 2.2 -1.6 -0.3 1.0
Medication for cholesterol 0.3 0.5 1.2 -0.5 0.3 -0.6 1.1 -0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.1 2.5 3.6 -1.9 1.5 -1.9 -0.0 1.7
Back pain experienced in last month 0.3 0.4 0.6 -0.6 0.6 -0.6 0.8 -0.7
Mineral and other dietary supplements 2.0 2.6 4.5 -1.4 2.1 -1.4 -2.1 -0.1
Breast cancer (self-reported) 0.7 0.8 2.3 0.7 -1.5 0.8 -0.7 -0.1
Asthma (self-reported) 0.7 1.4 6.3 -0.3 0.3 -0.4 -2.5 -0.4
Osteoporosis (self-reported) 0.4 0.4 1.4 0.7 0.1 0.4 0.3 -1.2
Osteoarthritis (self-reported) 0.8 1.0 1.5 1.1 -0.6 0.8 1.2 1.2
Medication: Aspirin 1.6 2.1 2.7 -1.2 1.3 -1.6 -1.6 -1.4
Medication: Gliclazide 2.5 2.8 5.3 -1.8 1.3 -1.9 -0.1 2.3
Illnesses of father: None of the above (group 1) 1.4 1.7 4.8 0.7 -2.2 1.3 -0.1 -1.3
Smoking status: Current 1.4 2.3 8.0 -0.4 -0.5 -0.6 1.6 2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.1 4.5 7.2 1.9 -2.7 2.0 2.7 -0.4
Whole body water mass 0.9 5.3 9.3 -2.7 1.3 -3.0 -2.5 1.4
Leg predicted mass (right) 1.0 5.2 7.7 -2.6 1.6 -2.8 -2.6 1.5
Arm fat mass (left) 1.5 6.0 10.5 -3.0 2.4 -3.2 -1.6 1.5
Number of self-reported non-cancer illnesses 2.0 3.4 4.9 -1.7 2.2 -2.2 -1.8 1.2
Average weekly champagne plus white wine intake 0.1 0.2 0.3 0.6 -0.2 0.3 -0.2 0.5
Miserableness 1.2 2.0 6.2 -0.2 0.7 0.1 1.8 2.5
Guilty feelings 1.4 2.1 4.0 -2.0 1.5 -1.7 -0.9 -0.7
Wears glasses or contact lenses 1.1 1.2 3.5 -0.9 1.9 -1.2 0.2 -0.5
Ever taken oral contraceptive pill 0.2 0.3 0.7 0.1 -0.4 0.7 -0.1 -0.8
Hearing aid user 0.3 0.3 1.2 1.1 0.5 0.4 0.1 -0.3
Mother’s age at death 0.6 0.8 1.5 0.5 -0.9 1.1 -1.2 0.4
Financial situation satisfaction 0.9 1.1 1.4 -1.2 1.1 -1.1 -0.6 -1.1
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.7 1.1 -0.8 1.6 0.0 -0.8
Commuting to job workplace: Public transport 0.4 0.5 1.0 0.4 -0.6 0.4 1.0 0.8
Eye problems/disorders: Glaucoma 0.4 0.4 1.1 0.5 -1.1 0.4 0.8 -0.1
Medication: Blood pressure 0.2 0.5 1.3 0.5 0.3 -0.0 -1.1 0.8
Pain type(s) experienced in last month: Hip pain 0.5 0.6 1.8 0.1 0.3 -0.6 -0.9 -1.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 4.1 0.9 -1.1 0.7 2.0 0.7
High cholesterol (Self-reported) 1.2 2.1 4.3 -1.7 1.5 -2.1 -1.0 -0.3
Medication: Bendroflumethiazide 0.7 1.1 4.0 -0.5 0.9 -0.7 0.4 2.0
Medication: Paracetamol 0.9 1.4 5.8 0.5 -0.4 0.7 2.4 -0.3
Medication: Lisinopril 0.5 0.6 1.2 -0.9 1.1 -0.8 -0.2 0.6
Medication: Atorvastatin 1.0 1.3 2.3 -1.5 0.7 -1.2 0.1 1.4
Illnesses of father: High blood pressure 0.5 0.7 1.2 -0.2 1.1 -0.6 -0.7 -1.1
Alcohol drinker status: Never 0.6 0.7 1.7 0.6 -1.0 0.5 0.5 -1.3
Ever smoked 0.9 1.6 4.7 -1.3 0.5 -0.7 -1.1 2.2
Basal metabolic rate 1.2 6.7 11.6 -3.1 1.7 -3.4 -2.6 1.7
Leg fat percentage (left) 1.4 4.9 9.6 -2.9 2.3 -3.1 -0.9 0.8
Arm fat-free mass (left) 1.3 6.4 12.5 -3.2 1.4 -3.5 -2.2 1.5
Number of operations (self-reported) 0.9 1.4 3.1 1.2 -1.7 1.4 -0.5 0.4
Average weekly beer plus cider intake 0.4 0.5 2.1 0.1 0.3 0.4 -1.5 -0.6
Irritability 0.2 0.3 0.5 -0.5 0.7 -0.6 -0.3 0.4
Risk taking 3.2 4.7 6.2 2.4 -2.4 2.2 2.5 -1.0
Ever had prostate specific antigen (PSA) test 2.6 3.0 5.2 -1.9 1.9 -1.4 -2.3 -0.8
Fractured/broken bones in last 5 years 1.1 1.4 3.4 1.2 -1.8 1.3 0.4 -0.1
Age started oral contraceptive pill 0.1 0.1 0.5 0.0 0.4 0.1 -0.7 -0.1
Diastolic blood pressure, automated reading 2.0 6.2 21.3 -0.8 2.4 -1.5 -4.6 -1.0
Ever depressed for a whole week 0.1 0.1 0.3 0.0 0.1 -0.3 -0.2 0.6
Unable to work because of sickness or disability 0.4 0.5 1.5 -0.2 1.2 -0.2 -0.9 0.4
Commuting to job workplace: Cycle 0.3 0.4 1.3 -0.1 -1.2 0.6 0.1 -0.3
Myopia 0.3 0.5 1.6 -0.0 -1.3 0.7 0.6 -0.1
Vascular/heart problems diagnosed by doctor 0.9 2.4 3.4 1.5 -1.7 1.8 1.8 -0.0
Cholesterol lowering medication 0.2 0.3 0.6 -0.7 0.1 -0.5 -0.8 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.1 1.4 3.0 -1.3 0.1 -1.2 -0.8 1.7
Pain experienced in last month 0.4 0.6 2.5 0.2 -0.7 0.2 0.3 1.6
Supplements: Calcium 1.4 1.5 2.5 1.2 -1.6 1.1 1.5 0.1
Basal cell carcinoma (self-reported) 0.1 0.2 0.6 0.8 -0.2 0.4 0.1 -0.2
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.6 0.1 0.4 -0.4 0.8 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.6 -0.4 -0.4 0.0 -0.3 -0.8
Heart disease (siblings) 0.9 1.1 2.8 -0.8 1.7 -0.9 -0.9 0.5
Alcohol drinker status: Previous 1.1 1.3 3.3 -0.9 1.8 -1.1 -1.0 -0.1
Pack years of smoking 0.5 0.8 1.6 -0.7 1.3 -0.7 -0.5 -1.0
Impedance of whole body 0.6 3.2 7.4 1.9 -1.1 2.7 1.5 -1.3
Leg fat mass (left) 2.0 7.8 14.9 -3.6 2.6 -3.9 -1.6 1.2
Arm predicted mass (left) 1.3 6.4 12.8 -3.1 1.5 -3.6 -2.3 1.4