Hub : Genes

RNF167

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0620	0.0240	7.2e-04	0.020	0.015	0.026	0.016	0.021	1.4e-03	5.8e-03	3.1e-04	4.1e-03	1.2e-03
2	GTEx	Adipose Subcutaneous	0.1360	0.0420	5.6e-04	0.071	NA	0.029	NA	0.040	1.9e-06	NA	1.8e-03	NA	3.2e-04
3	GTEx	Artery Aorta	0.1290	0.0460	1.8e-03	0.076	NA	0.028	NA	0.039	5.4e-05	NA	1.1e-02	NA	3.4e-03
4	GTEx	Artery Tibial	0.1074	0.0368	1.2e-03	0.018	NA	0.045	NA	0.035	1.3e-02	NA	1.8e-04	NA	8.4e-04
5	GTEx	Cells Transformed fibroblasts	0.1110	0.0440	4.7e-03	0.074	NA	0.036	NA	0.064	3.2e-06	NA	9.7e-04	NA	1.4e-05
6	GTEx	Esophagus Muscularis	0.1820	0.0540	8.6e-05	0.020	NA	0.024	NA	0.029	2.0e-02	NA	1.3e-02	NA	6.8e-03
7	GTEx	Muscle Skeletal	0.0834	0.0331	3.2e-03	0.006	NA	0.000	NA	0.002	7.1e-02	NA	2.8e-01	NA	1.8e-01
8	METSIM	Adipose	0.0663	0.0262	4.9e-04	0.008	0.012	0.002	0.011	0.010	1.9e-02	5.0e-03	1.2e-01	6.3e-03	1.1e-02
9	NTR	Blood	0.0332	0.0108	1.4e-04	0.010	0.007	0.006	0.008	0.007	1.9e-04	1.6e-03	3.5e-03	1.3e-03	1.5e-03
10	YFS	Blood	0.2457	0.0299	0.0e+00	0.336	0.307	0.345	0.336	0.338	2.7e-114	7.3e-103	2.5e-118	1.4e-114	2.1e-115
11	TCGA	Pheochromocytoma and Paraganglioma	0.1870	0.0790	1.2e-03	0.114	0.084	0.068	NA	0.081	2.8e-05	3.2e-04	1.1e-03	NA	4.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.4	0.7	2.1	1.4	-0.6	-0.2	-0.5	-0.9	-0.2	-0.8	0.6	0.8	-1.2	-1.0
Bipolar Disorder or Schizophrenia	0.2	0.4	1.3	-0.5	0.9	1.1	0.5	0.6	1.1	0.1	-0.3	0.4	-0.2	0.4
Depressed Affect (Nagel 2018)	1.3	2.6	7.2	2.2	1.0	1.1	2.7	1.6	1.6	-1.5	2.0	0.8	-1.3	0.9
Depression (Nagel 2018)	4.6	6.9	11.8	3.4	2.8	2.9	3.1	2.8	2.3	-2.1	3.3	1.6	-1.9	1.8
Intelligence (Savage-Jansen 2018)	0.5	1.4	3.8	-2.0	0.5	0.5	-0.8	0.4	0.0	1.9	-1.6	-0.9	1.9	0.1
Neuroticism (Nagel 2018)	0.8	1.8	3.8	2.0	0.7	0.8	1.7	1.3	1.9	-1.4	1.2	0.6	-1.3	0.9
Schizophrenia (2018)	0.8	1.6	3.4	-1.8	1.6	1.7	1.0	1.5	1.6	0.7	-0.8	-0.1	0.7	1.2
Schizophrenia vs Biploar Disorder	1.9	2.4	5.3	2.0	1.5	1.6	0.9	1.2	0.4	-2.3	1.1	2.0	-2.0	1.2
Worry (Nagel 2018)	1.3	2.7	9.4	3.1	-0.2	0.5	0.3	0.3	1.1	-2.9	1.6	1.5	-2.3	0.2
Alzheimer’s Disease (in mother)	1.1	1.3	7.1	-0.8	0.8	-0.0	1.8	0.9	2.7	0.2	0.3	0.2	0.3	1.3
Alzheimer’s Disease (in father)	2.7	2.9	8.4	0.8	1.5	1.5	2.9	1.4	2.4	-1.2	1.9	1.7	-1.3	0.9
Alzheimer’s Disease (including proxy)	2.4	3.4	13.9	-0.8	1.3	0.6	3.5	1.3	3.7	-0.3	1.1	2.0	-0.6	1.0
Crohns Disease (2017)	0.4	0.9	5.9	-0.4	0.1	-0.9	0.1	0.5	2.4	0.9	1.1	0.9	0.0	0.5
Irritable Bowel Disease (IBD)	0.6	1.5	6.7	1.3	0.2	-0.2	0.9	0.8	1.6	-0.5	2.6	1.3	-1.0	1.3
Ulcerative Colitis (UC)	1.5	2.8	9.0	3.0	-0.2	0.3	0.9	0.1	-0.3	-2.2	3.0	1.4	-2.1	0.8
Major Depression (MDD)	0.5	0.6	2.0	0.0	-0.8	-1.2	-0.9	-0.8	0.0	-0.4	-0.7	0.2	-0.2	-1.4
Reaction Time	1.1	2.1	6.2	1.4	0.6	-0.1	1.0	0.4	0.9	-1.7	2.2	2.5	-2.2	-0.5
Verbal and Numeric Reasoning (VNR)	1.5	3.7	8.9	-3.0	-1.2	-0.9	-1.7	-1.4	-1.2	2.2	-2.7	-1.6	2.4	-1.6
Breast Cancer	1.0	2.4	5.2	-0.5	-2.3	-1.9	-1.7	-1.9	-2.1	0.8	-1.9	-1.0	0.5	-0.9
Ovarian Cancer	1.5	2.0	4.4	-0.2	-1.9	-1.9	-0.3	-2.1	-1.1	-1.7	-0.8	1.2	-1.1	-1.4
Prostate Cancer	2.2	3.1	8.1	-0.1	2.1	2.2	2.5	2.1	2.8	-0.3	0.5	1.1	0.5	1.9
Age at First Birth	0.4	0.6	3.1	0.1	-0.4	-0.7	0.6	-0.3	-0.2	-0.7	-0.4	1.8	-1.1	-0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	-1.3	-1.3	-1.9	-0.6	-1.2	-0.7	0.9	0.5	0.5	0.9	-0.8
Coronary Artery Disease (CAD)	0.3	0.3	0.9	0.8	-0.7	-0.4	-0.3	-0.2	-0.2	-0.7	0.2	0.9	-0.2	0.8
Crohns Disease (2012)	0.6	0.9	5.7	-0.3	0.4	-0.2	1.2	0.5	2.4	0.5	1.1	0.7	-0.1	0.4
Mean Putamen Volume	0.6	0.7	4.0	-0.5	-0.4	-0.2	-2.0	-0.8	-1.0	0.5	-0.3	0.5	0.5	-0.9
Fasting Glucose	1.2	1.5	4.0	-0.1	1.5	1.2	1.9	1.2	2.0	-0.0	0.7	0.6	0.5	1.4
HbA1C	3.4	3.8	11.3	-1.4	1.8	1.7	-1.0	1.5	0.9	3.3	-0.6	-2.3	3.4	1.3
HDL Cholesterol	0.3	0.6	1.3	0.2	-1.0	-0.8	-0.7	-0.8	0.3	-0.4	0.9	-0.2	-1.0	-1.1
LDL Cholesterol	0.2	0.3	1.1	0.7	-0.3	0.1	-0.1	0.2	0.7	-1.0	0.9	-0.4	-0.0	0.7
Lupus	2.3	3.5	8.9	-2.7	-0.2	-0.0	-1.8	0.5	-0.7	2.9	-1.8	-3.0	2.5	-0.8
Neuroticism (2016)	1.5	2.2	6.7	2.3	-0.3	-0.6	1.6	0.1	-0.5	-2.5	1.0	1.2	-2.6	-0.0
Primary Biliary Cirrhosis	0.4	0.5	1.6	1.3	0.5	0.5	-0.9	0.6	-0.2	-0.3	1.1	-0.7	-0.3	0.8
Rheumatoid Arthritis	2.5	3.4	9.4	-3.1	1.4	1.1	-0.8	1.3	0.7	2.4	-2.0	-1.7	2.8	1.3
Schizophrenia (2014)	0.8	1.9	3.5	0.4	1.8	1.8	1.5	1.8	1.9	-0.8	0.3	1.1	-0.5	1.6
Triglycerides	0.6	1.0	2.7	-0.7	1.1	1.0	0.8	1.0	1.0	-0.6	-0.4	0.2	1.3	1.6
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.2	-0.6	0.6	0.2	0.6	0.6	1.5	-0.1	-0.2	0.4	0.3	0.6
Ulcerative Colitis	2.3	3.4	9.5	3.1	0.6	1.2	1.1	0.6	0.2	-2.3	2.8	2.0	-2.3	1.4
Blood Eosinophil Count	0.5	4.1	17.4	-4.2	0.2	-0.1	0.2	0.4	1.4	2.3	-2.1	-3.1	2.4	0.1
Blood Platelet Count	2.5	28.9	80.5	6.1	5.2	0.1	3.4	1.8	1.0	-6.5	9.0	6.2	-7.6	-4.4
Blood Red Count	0.4	4.2	17.5	-0.7	-2.1	-1.9	1.0	-1.7	1.8	-2.1	0.4	4.2	-2.6	-1.5
Blood White Count	1.1	7.9	26.2	-5.1	-1.6	-2.4	-2.5	-2.4	1.0	1.0	3.0	2.2	1.3	-4.7
Heel T-Score	0.3	2.8	11.2	-1.7	1.1	1.6	1.7	1.4	3.4	0.1	-0.6	2.0	0.5	1.7
BMI	1.0	5.7	21.3	-3.1	2.0	0.3	3.2	1.7	4.6	0.7	3.0	1.9	1.3	0.3
Height	0.4	8.1	15.5	3.4	-2.9	-2.6	-0.4	-2.6	-3.1	-3.8	3.1	2.4	-3.9	-1.1
Waist Hip Ratio (WHR)	0.1	0.3	0.9	0.1	-0.9	0.1	0.6	-0.5	0.0	-0.5	0.4	0.3	-0.8	-0.3
Systolic Blood Pressure	0.2	1.1	3.1	-1.6	-1.8	-1.3	-0.5	-1.1	-0.1	1.0	-1.2	0.1	0.1	-0.6
Smoking Status	2.5	6.1	16.0	-3.1	1.8	1.7	0.5	1.9	2.0	3.6	-0.9	-3.1	4.0	2.0
Allergy or Eczema	0.7	1.8	6.0	-0.5	1.8	1.0	2.2	1.5	2.4	0.0	1.1	0.4	0.4	1.2
Cardiovascular Disease	0.6	1.9	6.9	-2.6	-1.2	-1.0	-0.8	-0.8	0.2	1.9	-1.2	-1.2	1.9	-0.5
Hypothyroidism (self reported)	1.7	4.0	7.9	-1.6	-1.9	-2.8	-2.2	-2.3	-1.8	1.8	-1.9	-1.2	2.0	-2.0
Respiratory disease	0.3	0.6	2.2	-0.5	-0.1	-0.6	-1.5	-0.3	-0.4	0.9	1.0	-1.1	0.7	-0.2
Type 2 Diabetes (T2D) (2018)	1.0	1.9	5.8	-2.4	0.4	0.4	0.1	0.3	1.8	1.7	-1.4	-1.2	2.3	-0.3
Lung FEV1/FVC ratio	0.8	4.0	13.0	0.5	2.4	3.6	2.3	2.4	2.8	-0.6	1.4	0.8	0.1	1.8
Lung FVC	0.2	1.1	3.3	-1.5	-0.1	-0.4	-0.4	-0.3	1.1	1.8	-1.3	-0.8	1.4	-0.7
Neuroticism	0.3	0.7	1.9	0.8	0.2	0.9	0.7	1.0	1.4	-0.9	1.3	0.3	-0.7	0.1
Chronotype (morning person)	0.8	1.8	6.1	1.4	2.0	2.5	0.7	1.4	-0.3	-0.5	1.8	-1.0	-0.5	0.9
Hair Pigment	0.0	0.6	2.1	-0.5	-0.4	-0.2	-0.1	-0.4	0.7	1.3	-0.6	-1.5	1.2	-0.2
Tanning	0.0	0.4	1.2	-1.1	0.6	0.2	1.0	0.5	0.9	0.6	-0.4	0.4	0.3	0.3
Hand grip strength (left)	0.2	0.6	1.4	-0.5	-1.2	-1.1	-1.0	-0.9	-0.7	0.7	-0.3	0.8	0.3	-0.5
Number of treatments/medications taken	1.2	2.1	3.4	-1.3	-0.7	-1.8	-1.7	-1.4	-1.6	1.5	-0.6	-1.7	1.3	-1.8
Average weekly spirits intake	1.1	1.4	4.4	0.3	1.9	0.4	0.6	1.6	2.1	0.6	0.8	1.4	0.2	1.2
Sensitivity / hurt feelings	0.1	0.2	0.4	-0.4	0.4	0.6	-0.6	0.5	0.4	0.3	-0.4	0.0	0.3	0.2
Frequency of depressed mood in last 2 weeks	1.0	1.4	4.6	2.1	0.9	1.2	1.0	1.2	1.1	-0.4	1.4	1.3	-0.6	0.6
Hearing difficulty/problems: Yes	1.7	2.6	11.7	0.9	2.0	1.5	1.7	1.7	0.8	-0.5	3.4	0.4	-0.1	1.6
Relative age of first facial hair	0.2	0.5	2.1	-1.5	-0.7	-0.3	-1.0	-0.3	-0.0	0.4	-1.2	-0.1	0.5	0.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.0	-2.0	1.7	0.2	1.7	1.1	1.3	1.3	-0.9	0.1	1.4	0.8
Ever used hormone-replacement therapy (HRT)	2.0	2.5	5.0	-0.6	2.1	2.1	1.0	2.2	1.9	1.4	0.7	-1.1	1.3	1.8
Ever had hysterectomy (womb removed)	0.6	0.7	2.1	1.5	0.7	0.4	-0.1	0.5	0.7	-1.0	1.0	1.0	-1.0	0.6
Systolic blood pressure, automated reading	0.5	1.5	4.7	-2.2	0.9	0.9	-0.1	1.2	1.5	1.8	0.4	-0.1	1.6	0.7
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	7.0	-1.1	-1.8	-1.5	-0.4	-1.9	-0.5	-0.3	-0.4	0.1	0.1	-2.6
Angina	0.3	0.4	1.9	0.5	-0.6	-0.2	-0.6	-0.9	-0.4	-0.5	0.4	0.5	-0.3	-1.4
Medication for hormone replacement therapy	2.2	2.5	4.5	-1.5	-1.5	-1.1	-2.1	-2.0	-1.8	1.0	-1.8	-0.8	1.6	-1.7
Vitamin and mineral supplements	0.5	0.7	2.2	-1.5	-0.4	-0.5	0.9	-0.1	1.1	1.1	-0.8	0.1	0.9	-0.5
Supplements: Zinc	0.4	0.4	0.9	0.8	0.7	0.6	-0.9	0.1	-0.8	-0.2	0.8	-0.7	-0.3	-0.5
Medication: Co-codamol	1.4	1.7	7.7	1.4	1.7	1.6	0.6	1.3	0.3	-0.4	2.8	0.6	-0.4	0.7
Medication: Metformin	1.2	1.6	5.9	-2.4	-0.3	-0.1	-0.7	-0.7	0.4	0.8	-1.4	-1.8	1.3	-1.8
Diabetes (father)	1.2	1.4	3.9	-0.1	-1.9	-1.2	-1.2	-2.0	-1.3	0.1	-0.4	-0.7	-0.3	-1.7
Diabetes (mother)	0.2	0.2	0.8	0.3	-0.5	-0.3	-0.8	-0.2	-0.9	0.1	-0.1	-0.3	0.1	-0.5
Severe depression (siblings)	0.2	0.3	1.3	0.6	0.4	0.6	0.3	0.3	1.1	-0.4	0.3	0.3	-0.2	0.1
Pack years adult smoking proportion	0.3	0.5	1.9	-0.8	-0.5	-0.3	-1.4	-0.3	0.6	0.9	-0.9	-0.0	0.2	-0.2
Impedance of leg (right)	0.3	1.7	6.8	1.9	-1.2	-0.1	-1.1	-0.8	-2.6	-0.9	-1.1	-0.8	-1.5	-0.2
Leg fat-free mass (left)	0.4	2.0	6.8	-1.4	0.4	-1.0	2.0	0.1	2.6	0.2	2.0	1.8	0.6	0.2
Trunk fat percentage	0.4	1.6	5.0	-2.2	0.5	-0.3	1.1	0.0	2.0	0.6	1.9	0.7	0.8	-1.3
Hand grip strength (right)	0.3	0.8	5.0	0.4	0.0	-0.1	1.1	-0.1	1.0	-0.6	0.7	2.2	-0.8	0.4
Townsend deprivation index at recruitment	0.3	0.4	1.4	-0.4	-0.8	-0.1	-0.1	-0.6	-0.4	0.5	-0.3	-1.2	0.3	-0.8
Current tobacco smoking	2.2	3.6	11.4	-2.1	1.4	1.2	0.2	1.2	1.4	2.6	-1.2	-3.4	2.8	0.9
Average weekly fortified wine intake	1.7	2.0	4.7	1.8	-0.0	0.1	0.5	-0.8	-0.6	-2.2	1.4	1.9	-2.0	-1.6
Maternal smoking around birth	0.9	1.2	4.2	-1.6	0.6	0.6	0.6	1.1	2.1	1.3	0.3	-0.9	1.2	0.7
Fed-up feelings	0.9	1.7	5.1	0.6	0.4	0.5	2.3	1.0	2.0	-1.1	1.7	1.5	-1.2	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.8	3.8	8.9	1.4	2.4	2.3	3.0	2.6	1.5	-1.2	2.1	0.7	-0.9	1.7
Relative age voice broke	0.1	0.1	0.7	-0.8	-0.6	0.5	0.2	0.1	0.2	0.1	0.1	-0.1	0.0	0.1
Taking other prescription medications	2.4	3.7	8.4	-2.1	-0.5	-1.5	-2.2	-0.9	-1.7	2.6	-1.9	-2.9	2.4	-1.1
Age when periods started (menarche)	0.5	1.2	4.8	-0.5	-0.9	0.1	-1.8	-0.2	-1.4	1.0	-0.5	-2.2	0.9	-0.2
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.5	0.7	0.3	0.9	0.8	0.3	1.2	-1.6	1.0	1.5	-1.1	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	4.5	-0.8	1.2	2.1	1.7	1.6	2.0	0.7	0.3	-0.2	0.8	1.3
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	2.5	-0.4	-0.0	-0.6	1.6	0.1	1.1	-0.7	-0.1	0.1	-0.6	0.3
Qualifications: CSEs or equivalent	1.9	2.5	6.9	-2.0	-0.7	-1.3	-1.7	-0.9	-0.4	1.8	-1.6	-2.6	1.4	-1.9
Serious illness, injury or assault to yourself	0.5	0.6	1.2	-1.1	0.9	0.6	0.5	1.0	0.9	0.3	0.8	0.0	0.9	0.4
High blood pressure	0.3	0.9	2.7	-1.6	-0.4	-0.8	-0.5	-0.3	-0.3	1.1	-1.1	-1.5	0.8	-0.2
Hayfever, allergic rhinitis or eczema	1.1	2.4	6.0	0.6	2.1	1.3	2.3	1.6	2.4	-0.9	1.7	0.9	-0.4	1.0
Multivitamins +/- minerals	1.7	2.2	9.3	3.0	0.4	0.5	-0.2	-0.2	-1.0	-2.4	1.2	1.1	-2.2	0.1
Stomach or abdominal pain in last month	0.2	0.2	0.8	-0.9	-0.1	-0.1	0.2	0.0	0.7	-0.2	-0.0	-0.3	0.5	-0.8
Supplements: Glucosamine	0.5	0.7	1.7	1.3	0.3	-0.3	0.4	-0.1	-0.6	-1.2	1.3	1.3	-0.6	-0.2
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	-0.8	-1.3	-1.5	-0.9	-1.3	-1.2	0.7	-1.1	-0.5	0.1	-1.4
Medication: Atenolol	2.0	2.6	7.8	2.8	-0.0	0.3	0.8	-0.2	-0.4	-2.5	2.2	1.0	-2.7	-0.4
Medication: Levothyroxine sodium	2.7	4.6	7.8	-2.0	-2.0	-2.8	-2.6	-2.3	-1.8	2.0	-1.9	-1.4	2.5	-2.1
Sitting height	0.4	2.5	7.1	1.7	0.5	0.1	2.4	0.6	1.0	-1.6	2.7	1.8	-1.0	1.9
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	0.9	1.4	0.4	0.7	1.3	0.4	0.3	1.4	-0.7	-0.4	0.9
High blood pressure (mother)	1.0	1.4	4.1	-0.2	1.7	2.0	0.8	1.7	1.0	0.8	-0.2	-0.4	0.6	1.5
Body mass index (BMI)	1.0	4.3	16.2	-3.3	1.8	0.5	2.1	1.3	4.0	1.3	2.1	1.3	1.8	0.1
Impedance of leg (left)	0.3	1.6	5.9	1.9	-1.1	0.1	-0.6	-0.7	-2.4	-1.2	-0.9	-0.6	-1.7	-0.2
Leg predicted mass (left)	0.4	2.0	7.0	-1.6	0.4	-1.0	1.9	0.1	2.6	0.3	1.9	1.8	0.7	0.2
Trunk fat mass	0.4	1.9	5.9	-2.1	0.5	-0.6	1.5	0.0	2.4	0.4	2.2	1.2	0.7	-0.9
Waist circumference	0.7	2.5	11.4	-2.4	1.0	0.1	1.7	0.6	3.4	0.7	1.7	1.3	1.1	-0.1
Number of incorrect matches in round	0.5	0.8	2.3	0.9	1.2	1.5	0.0	1.2	0.4	-0.6	0.3	0.0	-0.7	1.0
Past tobacco smoking	2.4	4.4	12.4	3.2	-0.9	-0.8	1.0	-1.4	-0.4	-3.3	1.5	2.3	-3.5	-1.5
Alcohol usually taken with meals	1.1	1.8	4.6	1.6	-0.6	-0.7	-0.3	-0.6	-1.8	-1.6	1.6	2.1	-1.9	-0.1
Nervous feelings	0.5	1.0	3.8	1.9	-0.8	-0.7	-1.1	-0.6	-0.5	-1.2	-0.1	-0.7	-1.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.1	3.3	10.2	2.7	0.4	-0.1	2.0	0.4	0.1	-3.2	2.4	1.5	-2.5	0.2
Hearing difficulty/problems with background noise	2.0	3.1	9.1	1.6	1.9	1.4	2.1	1.8	2.0	-0.8	3.0	0.8	-1.0	1.8
Hair/balding pattern: Pattern 2	1.6	2.1	7.4	-0.8	1.6	1.4	1.9	1.7	2.7	0.6	-0.1	0.6	0.7	1.7
Had menopause	0.4	0.4	1.5	-0.5	1.2	0.9	0.5	1.1	0.2	0.2	-0.6	-0.3	0.1	0.7
Had other major operations	0.6	0.7	2.3	0.6	1.1	1.3	-0.4	1.0	0.0	0.2	1.5	0.3	0.6	0.7
Forced vital capacity (FVC)	0.2	0.7	1.8	0.5	-0.7	-0.7	1.3	-0.3	1.2	0.2	0.2	1.4	-0.2	1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	6.8	0.0	1.4	2.1	2.2	1.8	2.6	0.3	1.2	0.3	0.4	1.8
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.0	1.0	-1.1	-0.8	0.1	-0.9	0.1	-0.8	0.5	-0.1	-1.4	-1.4
Qualifications: None of the above	0.7	1.5	5.5	-0.5	-0.9	-0.8	-1.3	-0.5	-1.3	1.4	-1.6	-2.4	0.7	-0.9
Financial difficulties in last 2 years	0.9	1.3	3.3	0.0	1.0	0.6	1.8	1.0	1.2	-1.1	1.4	1.1	-0.5	1.5
Mouth/teeth dental problems	0.6	0.9	4.2	-0.6	-1.2	-1.1	-0.9	-1.1	-0.7	0.7	-2.0	-0.0	0.5	0.0
Heart attack	1.4	1.8	4.8	0.6	-1.9	-1.2	-1.5	-1.8	-1.5	-0.3	-1.0	-0.5	-0.4	-2.2
Allergy	0.2	0.4	2.2	-0.1	-1.5	-0.2	-0.7	-0.8	-0.6	0.2	-0.7	-0.3	0.0	0.2
Pain all over the body in last month	1.2	1.3	3.4	1.1	0.6	0.5	0.6	-0.2	0.4	-1.6	1.8	1.6	-1.4	-1.0
Diabetes (self-reported)	1.4	2.1	7.0	-2.6	-1.4	-0.7	-1.2	-1.3	-0.1	1.2	-1.4	-0.7	1.4	-2.1
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.4	-1.2	-0.3	-0.6	-0.5	-0.5	-0.6	-0.2	-1.0	-0.6	-0.1	-0.7
Medication: Ramipril	1.0	1.2	2.7	-0.4	-1.0	-1.1	-1.4	-1.3	-1.5	0.3	-0.8	-1.3	0.6	-1.6
Medication: Simvastatin	0.1	0.1	0.3	-0.5	0.0	-0.1	-0.6	0.2	0.1	-0.3	-0.2	-0.3	0.4	0.2
Fluid intelligence score	0.1	0.3	0.9	-0.7	-0.3	-0.1	0.1	-0.6	0.1	0.2	0.1	0.8	0.4	-1.0
Illnesses of siblings	1.1	1.5	4.6	1.2	0.6	0.5	1.9	0.8	2.1	-0.6	0.6	1.7	-0.5	1.5
Neuroticism score	0.2	0.3	2.1	-0.1	-0.3	0.1	0.5	0.7	1.5	-0.5	0.5	0.2	-0.5	-0.1
Weight	0.6	2.8	9.7	-1.6	0.7	-0.7	2.4	0.5	3.1	0.0	2.5	2.2	0.4	0.2
Impedance of arm (right)	1.0	4.9	17.0	2.6	-2.1	-1.3	-2.3	-2.3	-4.1	-1.7	-0.7	-1.1	-2.1	-2.1
Arm fat percentage (right)	0.5	2.1	8.6	-2.9	0.4	-0.7	0.7	-0.2	2.3	1.0	1.4	0.5	1.3	-1.6
Trunk fat-free mass	0.4	2.2	6.7	-0.2	0.2	-0.9	2.4	0.3	2.5	-0.3	1.9	2.6	-0.2	1.2
Hip circumference	0.6	2.5	11.3	-1.9	1.1	-0.2	1.8	0.8	3.4	0.5	1.7	1.9	0.8	0.1
Time employed in main current job	0.8	0.9	2.5	-1.0	0.7	1.1	0.0	1.3	1.6	0.1	0.3	1.2	0.4	1.2
Alcohol intake versus 10 years previously	0.6	0.8	2.7	0.6	-1.0	-0.9	-0.8	-0.6	-0.5	-0.9	0.2	1.6	-1.2	-0.7
Father’s age at death	1.7	2.3	7.0	2.6	0.1	0.4	1.0	0.4	1.1	-2.0	1.6	1.9	-2.2	0.8
Worrier / anxious feelings	0.9	1.8	5.0	1.2	0.7	0.6	0.7	1.0	1.7	-1.8	1.0	2.2	-1.4	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.7	0.1	0.5	0.4	0.5	0.4	0.6	-0.7	0.7	0.8	-0.5	0.1
Falls in the last year	1.1	1.5	2.6	-0.7	1.6	0.7	1.4	1.4	0.9	1.1	1.3	-1.6	1.2	1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.4	0.5	-1.0	-1.2	-0.3	-1.1	-0.8	-0.4	-0.4	0.7	-0.3	-0.5
Number of live births	0.9	1.3	6.4	-2.5	-0.8	-1.3	0.2	-0.7	-0.3	1.4	-0.5	-1.0	1.4	-0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.2	0.5	-0.3	0.2	1.9	0.0	2.0	0.2	0.7	2.0	-0.2	1.5
Pulse rate	1.3	2.1	7.1	1.3	1.8	1.2	1.7	1.4	0.7	-1.5	2.7	0.5	-1.3	0.6
Happiness	0.4	0.5	3.6	0.5	-0.5	-0.4	-0.2	-0.1	-0.8	0.1	-1.9	-0.3	-0.2	0.0
Noisy workplace	0.7	0.8	4.1	2.0	-0.4	-0.4	0.4	-0.1	-0.8	-1.2	-0.0	0.6	-1.2	0.6
Qualifications: A levels/AS levels or equivalent	0.5	1.1	4.4	-0.9	0.9	0.5	1.4	1.2	0.5	-0.4	0.4	1.4	0.1	2.1
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	3.9	-1.2	0.8	0.3	0.7	1.0	1.7	2.0	-0.9	0.5	1.5	1.8
Mouth/teeth dental problems: Dentures	0.8	1.4	4.5	0.9	2.1	1.4	0.5	1.5	0.3	-0.5	1.9	-1.0	-0.7	-0.2
Asthma	1.0	2.0	4.2	-2.0	-0.4	-1.0	-2.0	-0.6	-0.9	1.8	-1.0	-2.0	1.7	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	3.3	0.4	1.2	0.9	1.1	1.4	1.1	0.9	0.8	0.5	0.5	1.8
Medication: Cholesterol lowering	0.7	1.1	2.9	-0.7	-0.7	-0.2	-1.4	-1.1	-1.2	0.6	-0.7	-1.7	0.6	-1.5
Depression (self-reported)	0.9	1.0	2.3	1.5	0.8	0.9	1.3	0.8	0.9	-1.4	0.0	1.3	-0.9	0.3
Medication: Lansoprazole	0.2	0.2	0.8	-0.4	-0.3	-0.2	-0.9	-0.4	-0.4	0.5	-0.8	-0.0	0.4	-0.0
Prospective memory result	1.4	1.7	4.1	-0.8	1.9	1.8	0.5	2.0	1.2	0.8	-0.0	-1.1	0.7	1.6
Lung cancer (father)	3.7	4.3	10.6	-0.4	2.5	3.0	1.7	3.3	2.5	1.0	1.4	-0.8	1.3	2.7
Illnesses of mother	1.1	1.3	3.8	1.6	0.1	-0.4	1.0	-0.3	0.7	-1.9	0.6	1.5	-1.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	3.1	-0.1	-1.0	-0.5	1.1	-0.6	0.9	-0.2	-0.1	1.8	-0.7	0.5
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	-0.4	-0.4	-0.2	-0.6	-0.6	-0.5	-0.2	-0.4	0.3	-0.2	-0.7
Impedance of arm (left)	0.8	3.8	15.0	2.4	-1.7	-0.7	-2.0	-1.9	-3.9	-1.4	-0.8	-1.2	-1.8	-1.8
Arm fat mass (right)	0.6	2.3	7.6	-2.5	0.7	-0.7	1.6	0.1	2.8	0.7	2.0	1.1	1.1	-0.9
Trunk predicted mass	0.4	2.2	6.4	-0.1	0.3	-0.9	2.4	0.3	2.5	-0.3	1.9	2.5	-0.1	1.2
Standing height	0.4	4.5	10.4	3.2	-2.1	-2.5	1.1	-1.7	-1.6	-2.6	1.3	2.3	-2.8	0.2
Length of working week for main job	0.8	0.9	2.7	-0.5	1.0	0.6	0.1	0.9	0.8	1.6	1.1	-0.5	1.4	0.8
Exposure to tobacco smoke at home	0.9	1.0	4.8	1.2	0.8	0.8	0.8	0.6	0.6	-1.1	2.2	-0.1	-1.0	-0.3
Breastfed as a baby	0.5	0.6	1.2	0.6	0.9	0.3	0.4	1.1	0.1	-1.0	0.9	0.5	-0.8	0.8
Tense / ‘highly strung’	1.0	1.7	3.8	1.9	0.7	1.2	1.4	1.3	1.5	-1.7	1.1	0.6	-1.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.9	1.0	-0.5	-1.0	-0.6	-0.8	-0.1	-1.1	0.2	0.5	-1.4	-1.2
Hair/balding pattern: Pattern 4	0.5	1.2	3.2	-1.4	0.1	0.6	-1.4	0.1	-1.2	1.8	-0.6	-1.0	1.6	0.2
Birth weight of first child	1.0	1.8	5.7	1.5	1.0	0.6	2.4	0.9	0.5	-1.4	2.0	1.0	-1.4	0.2
Peak expiratory flow (PEF)	0.5	1.1	3.3	0.8	0.2	1.1	1.8	0.5	1.3	0.2	1.5	1.1	-0.1	1.1
Pulse wave reflection index	1.2	1.4	4.9	-1.1	-0.1	0.6	-1.0	-0.3	-0.6	2.0	-1.4	-1.3	2.2	-0.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.2	-1.3	-1.3	1.0	-1.0	1.0	-0.6	0.0	1.2	-0.9	-0.5
Loud music exposure frequency	0.4	0.4	1.1	-0.9	-1.1	-0.8	0.5	-0.8	0.2	0.1	-0.6	-0.8	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.8	-1.2	0.1	-0.5	0.2	-0.2	0.6	0.0	-0.3	1.3	0.2	0.2
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.8	-0.3	-0.7	-0.9	-0.0	-0.5	-0.5	0.2	-0.3	-0.2	0.2	-0.5
Blood clot in the leg (DVT)	0.4	0.5	1.4	-0.0	1.2	0.2	0.1	0.9	0.5	0.7	-0.6	1.1	0.8	0.3
Medication: Paracetamol	0.2	0.3	1.2	-0.9	-0.0	-0.2	0.1	0.2	1.1	0.6	0.7	0.2	0.7	-0.2
Headache pain in last month	0.9	1.5	3.4	-0.3	1.1	0.3	1.2	1.5	0.8	1.6	-1.2	-0.9	1.7	1.8
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.2	0.9	0.1	-0.5	0.5	0.4	1.0	-0.8	0.9	1.8	-0.9	0.5
Glaucoma (self-reported)	1.5	1.8	4.6	-2.2	0.0	0.4	-0.9	-0.1	-0.0	1.9	-1.8	-2.1	1.7	0.3
Gout (self-reported)	2.7	3.8	8.5	-0.9	-2.1	-2.1	-2.9	-2.1	-2.1	2.2	-1.0	-2.2	0.9	-1.6
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	8.6	-1.2	-1.9	-2.9	-2.0	-2.3	-1.2	1.1	-2.0	-0.3	1.2	-2.1
Medication: Amlodipine	0.7	1.0	2.8	-0.2	1.1	0.9	1.4	1.6	1.0	0.2	-0.4	-0.7	0.5	1.7
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.7	0.5	-0.5	-1.1	-0.1	-0.4	0.1	-0.9	1.6	0.5	-0.6	-0.3
Birth weight	1.2	2.6	6.1	2.3	0.7	0.1	1.6	0.8	-0.3	-1.4	2.5	2.3	-2.2	1.1
Chronic bronchitis/emphysema (mother)	4.0	4.6	11.5	-0.7	-2.9	-2.6	-2.5	-2.6	-2.4	0.7	-2.0	-0.5	0.2	-3.4
High blood pressure (siblings)	2.2	3.2	6.5	-1.9	-1.4	-1.5	-1.8	-1.9	-2.5	1.1	-1.6	-2.2	0.5	-2.4
Forced vital capacity (FVC), Best measure	0.1	0.5	1.7	0.2	-0.7	-0.4	1.0	-0.2	0.6	-0.2	-0.2	1.3	-0.6	1.1
Body fat percentage	0.5	2.1	7.8	-2.8	0.8	-0.1	1.3	0.3	2.6	0.8	1.6	0.7	1.2	-0.9
Leg fat percentage (right)	1.0	3.8	13.3	-3.4	1.8	0.7	1.7	1.4	3.6	1.4	1.5	0.7	1.8	0.2
Arm fat-free mass (right)	0.7	3.6	13.4	-1.2	1.1	-0.2	3.0	1.2	3.7	0.3	1.9	2.5	0.5	1.8
Exposure to tobacco smoke outside home	1.0	1.3	2.6	-0.1	1.4	0.6	1.5	1.4	1.1	1.1	1.6	0.7	0.9	1.4
Comparative body size at age 10	0.1	0.2	0.7	0.8	0.1	-0.1	0.1	-0.4	-0.7	-0.1	0.8	-0.3	-0.1	-0.4
Number of full brothers	0.5	0.6	1.9	0.8	1.0	0.3	1.1	0.7	0.9	0.1	1.4	-0.2	-0.2	0.4
Worry too long after embarrassment	0.4	0.6	2.4	0.4	-1.5	-1.6	-0.1	-0.6	0.1	-0.7	0.4	-0.0	-0.7	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.8	1.4	-0.0	-0.1	0.1	-0.4	1.1	-1.5	1.7	0.8	-1.2	-0.6
Wheeze or whistling in the chest in last year	0.6	1.0	3.6	-0.5	1.1	0.5	1.1	1.2	0.7	0.4	1.5	-1.9	0.2	0.3
Number of children fathered	2.0	2.2	7.0	-2.7	0.9	1.0	0.3	1.4	2.2	1.8	0.0	-0.2	2.1	1.2
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	2.5	0.9	-1.2	-1.0	-1.5	-1.3	-1.6	-0.6	-0.2	0.7	-1.3	-1.2
Age at first live birth	0.6	1.1	3.0	-0.3	0.4	1.1	0.9	1.0	1.2	-0.2	0.9	1.7	0.1	1.7
Pulse wave peak to peak time	0.1	0.1	0.5	0.7	-0.0	-0.1	0.5	0.3	0.2	-0.1	0.3	0.0	-0.1	0.6
Health satisfaction	1.5	1.9	5.7	2.4	1.2	1.1	1.2	1.2	0.4	-1.9	1.6	0.8	-1.6	0.8
Shortness of breath walking on level ground	0.5	0.6	1.5	-0.0	0.9	0.2	1.2	1.0	1.1	-1.2	-0.2	0.9	-0.6	0.3
Qualifications: College or University degree	0.3	1.0	3.7	0.3	0.3	0.4	1.0	0.9	0.2	-0.5	1.4	1.9	-0.2	1.5
Eye problems/disorders: None of the above	1.4	1.6	4.8	2.2	-0.5	-0.9	-0.1	-0.4	-0.2	-1.9	0.5	2.1	-1.9	0.4
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.6	1.7	1.0	0.8	0.9	0.7	0.7	-1.9	0.9	0.9	-1.4	1.0
Emphysema/chronic bronchitis	0.2	0.2	0.9	-0.5	0.1	-0.6	-0.3	0.2	-0.4	0.6	0.9	-0.1	-0.1	-0.5
Medication for pain relief, constipation, heartburn	0.3	0.5	1.6	1.0	-0.4	0.0	0.2	-0.5	-0.5	-1.3	-0.4	0.7	-1.1	0.0
Neck or shoulder pain in last month	1.2	1.7	3.4	-0.8	-0.9	-1.6	-1.7	-0.8	-1.7	1.0	-1.9	-1.1	1.7	-0.0
Medication: Blood pressure	0.3	0.5	2.9	-0.5	0.0	0.2	0.0	-0.0	-0.4	0.7	-0.9	-1.7	0.8	-0.0
Angina (self-reported)	0.6	0.8	2.9	0.4	-1.0	-0.5	-0.9	-1.3	-0.8	-0.6	0.1	0.6	-0.3	-1.7
Migraine (self-reported)	0.9	1.1	4.7	0.2	-0.5	-0.3	-0.9	-0.5	-1.9	1.0	-2.2	-0.6	0.7	-0.1
Medication: Ibuprofen	0.7	0.8	2.7	0.4	0.7	0.6	1.1	0.9	1.2	0.5	0.8	0.9	0.4	1.6
Medication: Allopurinol	3.0	4.0	8.6	-1.7	-2.1	-1.8	-2.4	-1.7	-1.4	2.9	-1.5	-2.9	1.6	-1.1
Medication: Omeprazole	0.2	0.3	1.6	-0.0	0.1	0.4	0.3	0.1	0.1	0.8	-0.6	-1.3	0.2	-0.4
Medication: Seretide 50 evohaler	0.4	0.5	1.5	0.4	-0.4	-0.7	-0.8	-0.5	-1.2	0.9	-0.8	-0.0	0.8	-0.1
Mean time to correctly identify matches	1.1	2.2	5.3	1.8	1.1	0.4	0.8	0.8	0.6	-1.8	2.3	2.0	-2.2	-0.4
Heart disease (mother)	0.8	1.0	2.7	-1.5	-0.3	0.2	-0.6	0.1	-1.1	1.6	-0.6	-1.3	1.5	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	1.3	-0.9	-0.5	-0.2	-1.2	-0.4	0.4	0.6	-0.5	-0.3	0.6	0.0
Whole body fat mass	0.5	2.1	7.2	-2.3	0.7	-0.5	1.5	0.3	2.7	0.6	2.0	1.1	1.1	-0.6
Leg fat mass (right)	1.0	3.8	13.9	-3.4	1.5	0.0	2.1	1.1	3.7	1.1	1.7	1.2	1.7	0.1
Arm predicted mass (right)	0.6	3.0	10.6	-1.2	1.0	-0.3	2.8	1.1	3.3	0.4	2.0	2.1	0.5	1.5
Pulse rate, automated reading	2.1	6.9	18.3	4.2	0.4	-0.5	1.6	0.2	-0.4	-4.3	3.8	2.3	-4.2	-0.5
Alcohol intake frequency.	0.7	1.6	5.1	0.0	-2.2	-2.1	-0.5	-2.1	-0.6	-0.5	-0.3	-0.1	-0.7	-1.6
Comparative height size at age 10	0.4	2.4	8.4	2.9	-0.1	-0.1	2.5	-0.1	-0.7	-1.8	1.0	0.6	-2.4	0.8
Number of full sisters	1.3	1.6	4.5	0.5	-1.2	-1.8	-1.8	-1.5	-2.1	-0.3	-0.4	0.9	-0.2	-1.3
Suffer from ‘nerves’	1.1	1.7	4.0	1.8	-0.2	0.0	0.5	0.4	1.5	-1.7	1.8	1.6	-2.0	0.1
Overall health rating	0.2	0.4	1.8	0.5	0.5	0.1	0.1	0.3	-0.1	-0.1	1.1	-1.4	0.5	0.2
Chest pain or discomfort	0.2	0.2	0.9	0.3	-0.4	-0.6	-0.4	-0.4	-0.3	-0.4	-0.1	1.0	-0.5	-0.3
Had major operations	0.2	0.3	0.9	0.2	0.6	0.2	-0.2	0.9	0.5	0.5	-0.2	-0.6	0.7	0.8
Age at last live birth	2.0	2.9	8.8	-0.7	1.4	1.7	2.3	2.0	3.0	0.3	0.4	0.5	0.8	2.8
Family relationship satisfaction	0.4	0.5	2.3	1.5	-0.1	0.1	-0.2	-0.2	-0.6	-0.6	-0.2	1.1	-1.0	-0.4
Leg pain on walking	0.6	0.7	2.2	1.5	0.9	-0.0	0.9	0.8	0.6	-1.0	0.6	0.9	-0.3	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.3	-0.5	1.3	1.4	1.6	1.1	1.8	-0.7	1.7	0.3	-0.2	1.0
Commuting to job workplace: Car/motor vehicle	1.5	1.7	5.6	-2.4	0.4	-0.2	0.1	0.5	1.4	1.7	-2.1	-0.2	1.7	0.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	5.2	1.0	-1.3	-0.5	-1.7	-1.4	-2.3	-0.1	-1.0	-1.5	-0.5	-1.3
Medication: Aspirin	0.2	0.3	1.1	-0.3	0.6	0.6	-0.1	0.5	-0.4	0.4	1.0	-0.6	0.2	-0.5
Supplements: Vitamin C	0.3	0.4	3.2	-0.7	-0.2	-0.4	-1.8	-0.4	-0.0	0.2	0.5	-0.2	0.0	-0.0
Knee pain experienced in last month	0.3	0.5	1.3	0.3	0.5	-0.2	0.4	0.5	-0.0	1.2	1.1	-0.7	1.1	0.7
Hypertension (Self-reported)	0.5	1.3	5.6	-2.4	-0.2	-0.8	-0.4	-0.3	-0.0	1.4	-1.4	-1.5	1.2	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.4	-0.1	-0.2	-0.1	-0.6	-0.1	-0.2	0.5	-0.6	0.0	-0.1	-0.4
Illnesses of father: Heart disease	0.6	0.8	4.9	0.5	1.0	1.2	0.8	0.8	0.2	-0.4	2.2	-0.1	0.1	0.3
Illnesses of siblings: Diabetes	3.8	4.6	7.2	-1.9	-1.7	-1.4	-2.6	-1.7	-2.7	2.1	-2.6	-2.5	1.8	-2.3
Smoking status: Previous	1.5	2.2	7.1	-2.7	0.1	-0.1	-1.2	0.6	-0.4	2.2	-1.5	-1.1	2.4	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.7	1.4	-1.2	-1.3	0.9	-1.1	-0.9	-1.9	0.8	1.0	-1.8	-0.5
Whole body fat-free mass	0.4	2.4	8.0	-0.9	0.5	-0.8	2.4	0.3	2.8	-0.0	2.0	2.4	0.3	0.9
Leg fat-free mass (right)	0.4	2.0	6.9	-1.3	0.4	-1.0	2.0	0.1	2.6	0.1	2.0	2.0	0.5	0.2
Arm fat percentage (left)	0.5	2.1	7.5	-2.7	0.7	-0.4	1.0	0.1	2.6	0.9	1.7	0.7	1.2	-1.4
Average weekly red wine intake	2.1	3.1	11.1	1.8	0.6	-0.2	1.2	0.3	-1.1	-2.4	3.3	2.2	-2.5	0.2
Handedness (chirality/laterality): Left-handed	1.0	1.2	4.2	-0.2	-0.9	-0.7	-1.9	-0.9	-2.0	0.3	-0.3	-1.1	0.7	-1.3
Mood swings	0.6	1.0	3.0	0.9	0.7	0.9	1.7	1.5	1.1	-0.7	0.3	0.7	-0.4	1.3
Loneliness, isolation	0.7	1.0	4.3	2.1	-0.7	-0.5	0.9	-0.0	-0.1	-0.8	1.0	1.1	-1.4	0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.3	-0.2	1.1	0.3	-0.2	0.8	0.2	0.7	0.8	-1.1	0.8	0.6
Ever had bowel cancer screening	0.6	0.7	2.6	-0.7	0.9	0.6	-0.6	0.8	-0.1	0.9	0.5	-1.6	1.1	-0.0
Diabetes diagnosed by doctor	1.2	2.0	7.8	-2.8	-0.9	-0.5	-0.7	-1.1	0.4	1.4	-1.4	-1.4	1.7	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.5	0.9	1.0	1.0	1.0	1.2	-0.7	-0.1	0.2	-1.2	-0.0	0.7
Friendships satisfaction	0.2	0.3	1.1	0.5	-0.6	-1.0	-0.1	-0.1	-0.3	0.6	-0.1	-0.6	-0.5	-0.3
Qualifications: nursing, teaching	1.6	2.5	4.9	1.3	2.0	2.2	1.7	1.6	1.2	-1.5	2.2	1.4	-0.6	0.9
Commuting to job workplace: Walk	1.6	1.8	3.3	1.8	-1.6	-0.7	-0.3	-1.5	-1.5	-1.6	-1.2	-1.0	-1.1	-1.5
Eye problems/disorders: Cataract	0.6	0.6	4.3	0.4	0.6	2.1	0.1	0.2	0.5	-0.4	1.4	0.3	0.2	0.0
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	5.5	0.1	1.3	1.5	0.8	1.6	1.9	-0.0	2.3	0.7	0.3	1.4
Medication for cholesterol	0.5	0.8	1.8	1.3	1.2	0.9	1.1	1.1	0.1	-0.6	0.9	0.4	-1.2	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.9	2.0	-0.6	1.3	1.4	1.4	1.2	0.6	-0.2	0.6	-0.3	-0.2	1.0
Back pain experienced in last month	0.6	0.9	1.8	-0.6	-1.0	-1.1	-0.4	-1.2	-0.7	0.9	-1.3	-0.8	1.1	-0.9
Mineral and other dietary supplements	2.5	3.4	11.6	-2.7	-1.3	-0.7	-0.4	-0.5	0.6	2.5	-3.4	-2.0	2.4	0.0
Breast cancer (self-reported)	0.6	0.7	4.1	-0.4	-0.2	0.4	-2.0	0.1	-0.9	1.1	1.0	-0.6	0.5	0.3
Asthma (self-reported)	0.8	1.6	3.7	-1.8	-0.2	-1.0	-1.8	-0.5	-0.7	1.6	-0.9	-1.9	1.5	-0.4
Osteoporosis (self-reported)	1.9	2.4	5.7	-0.4	-1.5	-1.6	-2.2	-1.7	-2.4	-0.0	-1.0	-1.7	-0.0	-2.0
Osteoarthritis (self-reported)	0.2	0.3	1.0	-0.7	0.5	-0.1	0.6	0.1	1.0	0.5	-0.8	-0.1	0.2	-0.4
Medication: Aspirin	0.3	0.4	1.5	-0.0	0.9	1.0	0.5	0.8	0.3	0.1	1.2	-0.2	0.0	-0.1
Medication: Gliclazide	0.6	0.7	2.5	-1.1	0.3	-1.1	-0.2	-0.0	-0.2	1.1	-0.8	-0.9	1.6	-0.1
Illnesses of father: None of the above (group 1)	1.2	1.5	2.9	0.5	-1.3	-1.7	-0.6	-1.3	-1.6	-1.4	-0.0	1.2	-1.4	-1.4
Smoking status: Current	2.0	3.1	9.4	-1.7	1.4	1.4	0.3	1.2	1.4	2.4	-0.7	-3.1	2.6	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	8.2	0.1	1.5	1.5	1.6	1.8	2.9	0.2	0.5	1.1	-0.2	1.9
Whole body water mass	0.4	2.4	8.1	-0.8	0.5	-0.8	2.4	0.4	2.9	-0.1	2.0	2.4	0.2	1.0
Leg predicted mass (right)	0.4	2.2	7.6	-1.3	0.5	-0.8	2.2	0.2	2.8	0.0	2.1	2.1	0.5	0.3
Arm fat mass (left)	0.6	2.4	8.3	-2.5	0.7	-0.5	1.6	0.2	2.9	0.8	1.9	1.3	1.1	-0.7
Number of self-reported non-cancer illnesses	1.0	1.7	3.7	-1.9	-0.3	-1.0	-1.3	-0.5	-0.8	1.7	-1.0	-1.8	1.4	-1.5
Average weekly champagne plus white wine intake	0.7	1.0	2.9	0.2	1.0	1.1	0.4	1.0	-0.2	0.9	-0.5	-1.2	1.3	1.7
Miserableness	0.2	0.4	1.1	0.3	-0.0	-0.1	1.0	0.5	0.7	-0.6	1.0	-0.1	-0.8	-0.1
Guilty feelings	0.8	1.2	2.7	-1.0	-1.7	-1.7	-1.1	-1.0	-0.3	0.2	-1.2	-1.2	0.5	-1.3
Wears glasses or contact lenses	0.5	0.5	1.2	1.0	0.7	-0.4	-1.0	0.3	-0.4	-0.4	1.1	0.3	-0.9	-0.8
Ever taken oral contraceptive pill	0.9	1.0	3.0	-0.4	0.4	0.9	1.3	0.4	1.6	-0.1	1.7	1.4	-0.0	0.2
Hearing aid user	1.1	1.2	4.9	0.4	-0.7	-0.8	-1.3	-1.1	-2.2	-1.1	0.2	0.4	-1.1	-1.3
Mother’s age at death	0.3	0.3	0.7	0.4	0.2	-0.4	-0.9	0.2	0.6	-0.9	0.7	0.4	-0.8	-0.2
Financial situation satisfaction	2.3	2.8	8.1	2.8	0.4	0.6	1.4	0.6	0.7	-2.5	1.8	2.0	-2.4	0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	3.2	1.2	0.1	0.0	0.3	-0.2	-0.2	-1.4	1.6	0.6	-1.8	-0.4
Commuting to job workplace: Public transport	0.3	0.3	1.1	0.9	-0.1	-0.1	-0.5	-0.1	-1.0	0.2	0.9	-0.3	-0.2	-0.6
Eye problems/disorders: Glaucoma	1.8	2.1	6.2	-2.4	0.3	0.7	-0.2	0.3	0.3	2.2	-1.1	-2.5	2.0	0.4
Medication: Blood pressure	0.1	0.2	0.8	-0.8	0.0	-0.3	-0.4	0.0	0.2	0.9	-0.2	-0.7	0.4	0.2
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.1	0.6	0.1	-0.8	-0.1	-0.3	-0.1	-0.9	0.8	1.0	-0.1	-0.2
Supplements: Fish oil (including cod liver oil)	1.7	2.2	6.4	2.5	1.4	1.1	-0.5	0.6	-0.7	-1.9	2.3	1.2	-1.7	0.3
High cholesterol (Self-reported)	0.3	0.5	1.9	-1.4	-0.6	-0.2	-0.9	-0.2	0.4	0.6	-0.4	-0.5	1.2	-0.3
Medication: Bendroflumethiazide	0.4	0.6	2.1	-0.5	-0.2	-0.5	-1.1	-0.1	-0.3	1.3	-0.5	-1.4	1.0	-0.1
Medication: Paracetamol	0.3	0.5	1.9	-0.0	0.4	0.2	0.7	0.5	1.2	-0.3	1.4	0.9	0.1	0.0
Medication: Lisinopril	0.4	0.6	2.6	0.5	0.6	0.9	1.2	0.6	1.6	-0.3	0.6	-0.3	-0.1	0.2
Medication: Atorvastatin	0.8	1.0	3.5	-1.5	-0.5	-0.0	-0.5	-0.6	-0.6	1.2	-0.3	-1.9	1.1	-0.9
Illnesses of father: High blood pressure	0.5	0.6	2.2	0.7	-0.3	0.2	0.9	-0.8	-0.7	-0.5	0.2	-1.5	-0.8	-0.8
Alcohol drinker status: Never	0.5	0.7	2.4	1.1	-0.1	0.1	-0.3	-0.8	-0.4	-1.6	0.3	0.5	-0.9	-1.2
Ever smoked	3.2	5.6	15.0	-3.4	1.5	1.6	-1.3	1.7	0.7	3.7	-1.5	-2.6	3.9	1.7
Basal metabolic rate	0.4	2.3	7.7	-1.1	0.3	-1.0	2.3	0.1	2.8	0.0	2.0	2.3	0.4	0.6
Leg fat percentage (left)	1.2	4.3	15.5	-3.4	1.9	0.9	2.1	1.6	3.9	1.2	1.8	0.7	1.7	0.3
Arm fat-free mass (left)	0.6	2.9	10.3	-1.3	0.8	-0.4	2.7	0.8	3.2	0.4	2.0	2.2	0.5	1.3
Number of operations (self-reported)	1.1	1.7	3.7	0.7	1.8	1.9	1.1	1.9	1.7	0.2	0.7	0.6	0.6	1.5
Average weekly beer plus cider intake	0.1	0.2	0.6	-0.4	0.3	0.5	0.5	0.2	0.7	-0.1	0.3	0.6	0.5	-0.2
Irritability	0.8	1.4	5.1	-1.2	0.8	1.3	1.5	1.5	2.3	0.3	-0.1	1.1	0.4	0.8
Risk taking	2.1	3.1	6.8	-1.5	1.9	1.8	1.1	2.1	2.6	1.9	-0.0	-0.4	2.1	2.1
Ever had prostate specific antigen (PSA) test	0.8	0.9	4.1	0.6	0.8	0.4	0.5	0.8	0.4	-1.2	0.9	2.0	-0.9	0.5
Fractured/broken bones in last 5 years	1.1	1.4	3.6	-1.9	-0.4	-0.7	-1.2	-0.5	-0.9	1.6	-1.9	-1.2	1.1	-0.3
Age started oral contraceptive pill	2.4	3.0	5.7	1.7	1.4	1.8	2.3	2.1	1.7	-0.9	2.4	0.6	-0.9	2.2
Diastolic blood pressure, automated reading	0.3	0.8	2.7	-1.4	0.4	-0.0	-0.4	0.5	1.6	0.5	1.6	0.2	0.6	0.0
Ever depressed for a whole week	1.0	1.3	3.2	-0.6	-1.6	-1.4	-0.8	-1.2	-0.4	1.2	-1.3	-0.8	0.4	-1.8
Unable to work because of sickness or disability	0.9	1.1	3.3	0.5	-0.8	-1.3	1.2	-1.0	-0.1	-1.8	0.7	1.3	-1.3	-0.6
Commuting to job workplace: Cycle	0.8	1.0	6.2	-1.0	-0.8	-0.8	-0.2	-0.3	-0.8	1.1	-0.3	-2.5	0.2	-0.5
Myopia	0.7	1.1	3.0	1.3	1.3	1.0	-0.4	1.5	-0.2	0.0	-0.3	-1.1	0.6	1.7
Vascular/heart problems diagnosed by doctor	0.5	1.3	3.2	1.8	0.8	1.0	0.8	0.7	0.2	-1.5	1.4	1.8	-1.1	0.4
Cholesterol lowering medication	0.4	0.5	2.3	-1.0	0.2	0.3	0.3	0.7	1.5	-0.0	0.2	0.4	0.9	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.7	-0.0	0.2	0.3	0.2	0.4	0.3	0.8	-0.8	-0.8	0.3	0.2
Pain experienced in last month	0.7	1.1	5.4	0.5	-0.2	-0.0	0.6	-0.3	-0.1	-1.6	0.7	1.5	-2.3	-1.0
Supplements: Calcium	1.3	1.4	4.8	1.1	-0.7	-0.6	-0.4	-0.5	-0.9	-2.0	0.8	1.7	-2.2	-0.7
Basal cell carcinoma (self-reported)	0.5	0.6	2.4	-0.1	0.1	0.4	-0.2	0.4	1.1	1.2	-0.8	-0.1	1.5	0.7
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.5	0.6	-1.9	-1.2	-1.5	-1.8	-1.6	-0.2	-1.1	-0.7	-0.4	-2.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.4	-0.3	1.2	0.3	0.1	0.9	0.6	0.8	-1.0	1.1	1.0	0.4
Heart disease (siblings)	1.0	1.3	4.0	-1.2	0.3	-0.2	-1.1	0.4	-0.9	1.5	-1.4	-2.0	1.5	-0.2
Alcohol drinker status: Previous	1.4	1.5	4.5	-0.5	-2.1	-2.0	-0.4	-1.7	-1.0	-0.4	-0.8	-0.3	-0.4	-1.7
Pack years of smoking	0.3	0.4	1.9	-0.5	-0.5	-0.3	-1.4	-0.4	0.4	0.5	-0.7	0.4	-0.1	-0.5
Impedance of whole body	0.6	2.8	11.2	2.5	-1.4	-0.3	-1.4	-1.2	-3.3	-1.3	-0.8	-0.9	-2.0	-1.0
Leg fat mass (left)	1.0	3.9	14.5	-3.1	1.5	0.1	2.3	1.2	3.8	1.0	2.0	1.3	1.6	0.2
Arm predicted mass (left)	0.6	3.1	11.8	-1.3	0.7	-0.4	2.7	0.8	3.4	0.4	2.0	2.5	0.5	1.4