Hub : Genes

RNF167

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0620 0.0240 7.2e-04 0.020 0.015 0.026 0.016 0.021 1.4e-03 5.8e-03 3.1e-04 4.1e-03 1.2e-03
2 GTEx Adipose Subcutaneous 0.1360 0.0420 5.6e-04 0.071 NA 0.029 NA 0.040 1.9e-06 NA 1.8e-03 NA 3.2e-04
3 GTEx Artery Aorta 0.1290 0.0460 1.8e-03 0.076 NA 0.028 NA 0.039 5.4e-05 NA 1.1e-02 NA 3.4e-03
4 GTEx Artery Tibial 0.1074 0.0368 1.2e-03 0.018 NA 0.045 NA 0.035 1.3e-02 NA 1.8e-04 NA 8.4e-04
5 GTEx Cells Transformed fibroblasts 0.1110 0.0440 4.7e-03 0.074 NA 0.036 NA 0.064 3.2e-06 NA 9.7e-04 NA 1.4e-05
6 GTEx Esophagus Muscularis 0.1820 0.0540 8.6e-05 0.020 NA 0.024 NA 0.029 2.0e-02 NA 1.3e-02 NA 6.8e-03
7 GTEx Muscle Skeletal 0.0834 0.0331 3.2e-03 0.006 NA 0.000 NA 0.002 7.1e-02 NA 2.8e-01 NA 1.8e-01
8 METSIM Adipose 0.0663 0.0262 4.9e-04 0.008 0.012 0.002 0.011 0.010 1.9e-02 5.0e-03 1.2e-01 6.3e-03 1.1e-02
9 NTR Blood 0.0332 0.0108 1.4e-04 0.010 0.007 0.006 0.008 0.007 1.9e-04 1.6e-03 3.5e-03 1.3e-03 1.5e-03
10 YFS Blood 0.2457 0.0299 0.0e+00 0.336 0.307 0.345 0.336 0.338 2.7e-114 7.3e-103 2.5e-118 1.4e-114 2.1e-115
11 TCGA Pheochromocytoma and Paraganglioma 0.1870 0.0790 1.2e-03 0.114 0.084 0.068 NA 0.081 2.8e-05 3.2e-04 1.1e-03 NA 4.0e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.4 0.7 2.1 1.4 -0.6 -0.2 -0.5 -0.9 -0.2 -0.8 0.6 0.8 -1.2 -1.0
Bipolar Disorder or Schizophrenia 0.2 0.4 1.3 -0.5 0.9 1.1 0.5 0.6 1.1 0.1 -0.3 0.4 -0.2 0.4
Depressed Affect (Nagel 2018) 1.3 2.6 7.2 2.2 1.0 1.1 2.7 1.6 1.6 -1.5 2.0 0.8 -1.3 0.9
Depression (Nagel 2018) 4.6 6.9 11.8 3.4 2.8 2.9 3.1 2.8 2.3 -2.1 3.3 1.6 -1.9 1.8
Intelligence (Savage-Jansen 2018) 0.5 1.4 3.8 -2.0 0.5 0.5 -0.8 0.4 0.0 1.9 -1.6 -0.9 1.9 0.1
Neuroticism (Nagel 2018) 0.8 1.8 3.8 2.0 0.7 0.8 1.7 1.3 1.9 -1.4 1.2 0.6 -1.3 0.9
Schizophrenia (2018) 0.8 1.6 3.4 -1.8 1.6 1.7 1.0 1.5 1.6 0.7 -0.8 -0.1 0.7 1.2
Schizophrenia vs Biploar Disorder 1.9 2.4 5.3 2.0 1.5 1.6 0.9 1.2 0.4 -2.3 1.1 2.0 -2.0 1.2
Worry (Nagel 2018) 1.3 2.7 9.4 3.1 -0.2 0.5 0.3 0.3 1.1 -2.9 1.6 1.5 -2.3 0.2
Alzheimer’s Disease (in mother) 1.1 1.3 7.1 -0.8 0.8 -0.0 1.8 0.9 2.7 0.2 0.3 0.2 0.3 1.3
Alzheimer’s Disease (in father) 2.7 2.9 8.4 0.8 1.5 1.5 2.9 1.4 2.4 -1.2 1.9 1.7 -1.3 0.9
Alzheimer’s Disease (including proxy) 2.4 3.4 13.9 -0.8 1.3 0.6 3.5 1.3 3.7 -0.3 1.1 2.0 -0.6 1.0
Crohns Disease (2017) 0.4 0.9 5.9 -0.4 0.1 -0.9 0.1 0.5 2.4 0.9 1.1 0.9 0.0 0.5
Irritable Bowel Disease (IBD) 0.6 1.5 6.7 1.3 0.2 -0.2 0.9 0.8 1.6 -0.5 2.6 1.3 -1.0 1.3
Ulcerative Colitis (UC) 1.5 2.8 9.0 3.0 -0.2 0.3 0.9 0.1 -0.3 -2.2 3.0 1.4 -2.1 0.8
Major Depression (MDD) 0.5 0.6 2.0 0.0 -0.8 -1.2 -0.9 -0.8 0.0 -0.4 -0.7 0.2 -0.2 -1.4
Reaction Time 1.1 2.1 6.2 1.4 0.6 -0.1 1.0 0.4 0.9 -1.7 2.2 2.5 -2.2 -0.5
Verbal and Numeric Reasoning (VNR) 1.5 3.7 8.9 -3.0 -1.2 -0.9 -1.7 -1.4 -1.2 2.2 -2.7 -1.6 2.4 -1.6
Breast Cancer 1.0 2.4 5.2 -0.5 -2.3 -1.9 -1.7 -1.9 -2.1 0.8 -1.9 -1.0 0.5 -0.9
Ovarian Cancer 1.5 2.0 4.4 -0.2 -1.9 -1.9 -0.3 -2.1 -1.1 -1.7 -0.8 1.2 -1.1 -1.4
Prostate Cancer 2.2 3.1 8.1 -0.1 2.1 2.2 2.5 2.1 2.8 -0.3 0.5 1.1 0.5 1.9
Age at First Birth 0.4 0.6 3.1 0.1 -0.4 -0.7 0.6 -0.3 -0.2 -0.7 -0.4 1.8 -1.1 -0.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 3.5 -1.3 -1.3 -1.9 -0.6 -1.2 -0.7 0.9 0.5 0.5 0.9 -0.8
Coronary Artery Disease (CAD) 0.3 0.3 0.9 0.8 -0.7 -0.4 -0.3 -0.2 -0.2 -0.7 0.2 0.9 -0.2 0.8
Crohns Disease (2012) 0.6 0.9 5.7 -0.3 0.4 -0.2 1.2 0.5 2.4 0.5 1.1 0.7 -0.1 0.4
Mean Putamen Volume 0.6 0.7 4.0 -0.5 -0.4 -0.2 -2.0 -0.8 -1.0 0.5 -0.3 0.5 0.5 -0.9
Fasting Glucose 1.2 1.5 4.0 -0.1 1.5 1.2 1.9 1.2 2.0 -0.0 0.7 0.6 0.5 1.4
HbA1C 3.4 3.8 11.3 -1.4 1.8 1.7 -1.0 1.5 0.9 3.3 -0.6 -2.3 3.4 1.3
HDL Cholesterol 0.3 0.6 1.3 0.2 -1.0 -0.8 -0.7 -0.8 0.3 -0.4 0.9 -0.2 -1.0 -1.1
LDL Cholesterol 0.2 0.3 1.1 0.7 -0.3 0.1 -0.1 0.2 0.7 -1.0 0.9 -0.4 -0.0 0.7
Lupus 2.3 3.5 8.9 -2.7 -0.2 -0.0 -1.8 0.5 -0.7 2.9 -1.8 -3.0 2.5 -0.8
Neuroticism (2016) 1.5 2.2 6.7 2.3 -0.3 -0.6 1.6 0.1 -0.5 -2.5 1.0 1.2 -2.6 -0.0
Primary Biliary Cirrhosis 0.4 0.5 1.6 1.3 0.5 0.5 -0.9 0.6 -0.2 -0.3 1.1 -0.7 -0.3 0.8
Rheumatoid Arthritis 2.5 3.4 9.4 -3.1 1.4 1.1 -0.8 1.3 0.7 2.4 -2.0 -1.7 2.8 1.3
Schizophrenia (2014) 0.8 1.9 3.5 0.4 1.8 1.8 1.5 1.8 1.9 -0.8 0.3 1.1 -0.5 1.6
Triglycerides 0.6 1.0 2.7 -0.7 1.1 1.0 0.8 1.0 1.0 -0.6 -0.4 0.2 1.3 1.6
Type 2 Diabetes (T2D) (2012) 0.4 0.4 2.2 -0.6 0.6 0.2 0.6 0.6 1.5 -0.1 -0.2 0.4 0.3 0.6
Ulcerative Colitis 2.3 3.4 9.5 3.1 0.6 1.2 1.1 0.6 0.2 -2.3 2.8 2.0 -2.3 1.4
Blood Eosinophil Count 0.5 4.1 17.4 -4.2 0.2 -0.1 0.2 0.4 1.4 2.3 -2.1 -3.1 2.4 0.1
Blood Platelet Count 2.5 28.9 80.5 6.1 5.2 0.1 3.4 1.8 1.0 -6.5 9.0 6.2 -7.6 -4.4
Blood Red Count 0.4 4.2 17.5 -0.7 -2.1 -1.9 1.0 -1.7 1.8 -2.1 0.4 4.2 -2.6 -1.5
Blood White Count 1.1 7.9 26.2 -5.1 -1.6 -2.4 -2.5 -2.4 1.0 1.0 3.0 2.2 1.3 -4.7
Heel T-Score 0.3 2.8 11.2 -1.7 1.1 1.6 1.7 1.4 3.4 0.1 -0.6 2.0 0.5 1.7
BMI 1.0 5.7 21.3 -3.1 2.0 0.3 3.2 1.7 4.6 0.7 3.0 1.9 1.3 0.3
Height 0.4 8.1 15.5 3.4 -2.9 -2.6 -0.4 -2.6 -3.1 -3.8 3.1 2.4 -3.9 -1.1
Waist Hip Ratio (WHR) 0.1 0.3 0.9 0.1 -0.9 0.1 0.6 -0.5 0.0 -0.5 0.4 0.3 -0.8 -0.3
Systolic Blood Pressure 0.2 1.1 3.1 -1.6 -1.8 -1.3 -0.5 -1.1 -0.1 1.0 -1.2 0.1 0.1 -0.6
Smoking Status 2.5 6.1 16.0 -3.1 1.8 1.7 0.5 1.9 2.0 3.6 -0.9 -3.1 4.0 2.0
Allergy or Eczema 0.7 1.8 6.0 -0.5 1.8 1.0 2.2 1.5 2.4 0.0 1.1 0.4 0.4 1.2
Cardiovascular Disease 0.6 1.9 6.9 -2.6 -1.2 -1.0 -0.8 -0.8 0.2 1.9 -1.2 -1.2 1.9 -0.5
Hypothyroidism (self reported) 1.7 4.0 7.9 -1.6 -1.9 -2.8 -2.2 -2.3 -1.8 1.8 -1.9 -1.2 2.0 -2.0
Respiratory disease 0.3 0.6 2.2 -0.5 -0.1 -0.6 -1.5 -0.3 -0.4 0.9 1.0 -1.1 0.7 -0.2
Type 2 Diabetes (T2D) (2018) 1.0 1.9 5.8 -2.4 0.4 0.4 0.1 0.3 1.8 1.7 -1.4 -1.2 2.3 -0.3
Lung FEV1/FVC ratio 0.8 4.0 13.0 0.5 2.4 3.6 2.3 2.4 2.8 -0.6 1.4 0.8 0.1 1.8
Lung FVC 0.2 1.1 3.3 -1.5 -0.1 -0.4 -0.4 -0.3 1.1 1.8 -1.3 -0.8 1.4 -0.7
Neuroticism 0.3 0.7 1.9 0.8 0.2 0.9 0.7 1.0 1.4 -0.9 1.3 0.3 -0.7 0.1
Chronotype (morning person) 0.8 1.8 6.1 1.4 2.0 2.5 0.7 1.4 -0.3 -0.5 1.8 -1.0 -0.5 0.9
Hair Pigment 0.0 0.6 2.1 -0.5 -0.4 -0.2 -0.1 -0.4 0.7 1.3 -0.6 -1.5 1.2 -0.2
Tanning 0.0 0.4 1.2 -1.1 0.6 0.2 1.0 0.5 0.9 0.6 -0.4 0.4 0.3 0.3
Hand grip strength (left) 0.2 0.6 1.4 -0.5 -1.2 -1.1 -1.0 -0.9 -0.7 0.7 -0.3 0.8 0.3 -0.5
Number of treatments/medications taken 1.2 2.1 3.4 -1.3 -0.7 -1.8 -1.7 -1.4 -1.6 1.5 -0.6 -1.7 1.3 -1.8
Average weekly spirits intake 1.1 1.4 4.4 0.3 1.9 0.4 0.6 1.6 2.1 0.6 0.8 1.4 0.2 1.2
Sensitivity / hurt feelings 0.1 0.2 0.4 -0.4 0.4 0.6 -0.6 0.5 0.4 0.3 -0.4 0.0 0.3 0.2
Frequency of depressed mood in last 2 weeks 1.0 1.4 4.6 2.1 0.9 1.2 1.0 1.2 1.1 -0.4 1.4 1.3 -0.6 0.6
Hearing difficulty/problems: Yes 1.7 2.6 11.7 0.9 2.0 1.5 1.7 1.7 0.8 -0.5 3.4 0.4 -0.1 1.6
Relative age of first facial hair 0.2 0.5 2.1 -1.5 -0.7 -0.3 -1.0 -0.3 -0.0 0.4 -1.2 -0.1 0.5 0.0
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 4.0 -2.0 1.7 0.2 1.7 1.1 1.3 1.3 -0.9 0.1 1.4 0.8
Ever used hormone-replacement therapy (HRT) 2.0 2.5 5.0 -0.6 2.1 2.1 1.0 2.2 1.9 1.4 0.7 -1.1 1.3 1.8
Ever had hysterectomy (womb removed) 0.6 0.7 2.1 1.5 0.7 0.4 -0.1 0.5 0.7 -1.0 1.0 1.0 -1.0 0.6
Systolic blood pressure, automated reading 0.5 1.5 4.7 -2.2 0.9 0.9 -0.1 1.2 1.5 1.8 0.4 -0.1 1.6 0.7
Eye problems/disorders: Diabetes related eye disease 1.5 1.6 7.0 -1.1 -1.8 -1.5 -0.4 -1.9 -0.5 -0.3 -0.4 0.1 0.1 -2.6
Angina 0.3 0.4 1.9 0.5 -0.6 -0.2 -0.6 -0.9 -0.4 -0.5 0.4 0.5 -0.3 -1.4
Medication for hormone replacement therapy 2.2 2.5 4.5 -1.5 -1.5 -1.1 -2.1 -2.0 -1.8 1.0 -1.8 -0.8 1.6 -1.7
Vitamin and mineral supplements 0.5 0.7 2.2 -1.5 -0.4 -0.5 0.9 -0.1 1.1 1.1 -0.8 0.1 0.9 -0.5
Supplements: Zinc 0.4 0.4 0.9 0.8 0.7 0.6 -0.9 0.1 -0.8 -0.2 0.8 -0.7 -0.3 -0.5
Medication: Co-codamol 1.4 1.7 7.7 1.4 1.7 1.6 0.6 1.3 0.3 -0.4 2.8 0.6 -0.4 0.7
Medication: Metformin 1.2 1.6 5.9 -2.4 -0.3 -0.1 -0.7 -0.7 0.4 0.8 -1.4 -1.8 1.3 -1.8
Diabetes (father) 1.2 1.4 3.9 -0.1 -1.9 -1.2 -1.2 -2.0 -1.3 0.1 -0.4 -0.7 -0.3 -1.7
Diabetes (mother) 0.2 0.2 0.8 0.3 -0.5 -0.3 -0.8 -0.2 -0.9 0.1 -0.1 -0.3 0.1 -0.5
Severe depression (siblings) 0.2 0.3 1.3 0.6 0.4 0.6 0.3 0.3 1.1 -0.4 0.3 0.3 -0.2 0.1
Pack years adult smoking proportion 0.3 0.5 1.9 -0.8 -0.5 -0.3 -1.4 -0.3 0.6 0.9 -0.9 -0.0 0.2 -0.2
Impedance of leg (right) 0.3 1.7 6.8 1.9 -1.2 -0.1 -1.1 -0.8 -2.6 -0.9 -1.1 -0.8 -1.5 -0.2
Leg fat-free mass (left) 0.4 2.0 6.8 -1.4 0.4 -1.0 2.0 0.1 2.6 0.2 2.0 1.8 0.6 0.2
Trunk fat percentage 0.4 1.6 5.0 -2.2 0.5 -0.3 1.1 0.0 2.0 0.6 1.9 0.7 0.8 -1.3
Hand grip strength (right) 0.3 0.8 5.0 0.4 0.0 -0.1 1.1 -0.1 1.0 -0.6 0.7 2.2 -0.8 0.4
Townsend deprivation index at recruitment 0.3 0.4 1.4 -0.4 -0.8 -0.1 -0.1 -0.6 -0.4 0.5 -0.3 -1.2 0.3 -0.8
Current tobacco smoking 2.2 3.6 11.4 -2.1 1.4 1.2 0.2 1.2 1.4 2.6 -1.2 -3.4 2.8 0.9
Average weekly fortified wine intake 1.7 2.0 4.7 1.8 -0.0 0.1 0.5 -0.8 -0.6 -2.2 1.4 1.9 -2.0 -1.6
Maternal smoking around birth 0.9 1.2 4.2 -1.6 0.6 0.6 0.6 1.1 2.1 1.3 0.3 -0.9 1.2 0.7
Fed-up feelings 0.9 1.7 5.1 0.6 0.4 0.5 2.3 1.0 2.0 -1.1 1.7 1.5 -1.2 0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 2.8 3.8 8.9 1.4 2.4 2.3 3.0 2.6 1.5 -1.2 2.1 0.7 -0.9 1.7
Relative age voice broke 0.1 0.1 0.7 -0.8 -0.6 0.5 0.2 0.1 0.2 0.1 0.1 -0.1 0.0 0.1
Taking other prescription medications 2.4 3.7 8.4 -2.1 -0.5 -1.5 -2.2 -0.9 -1.7 2.6 -1.9 -2.9 2.4 -1.1
Age when periods started (menarche) 0.5 1.2 4.8 -0.5 -0.9 0.1 -1.8 -0.2 -1.4 1.0 -0.5 -2.2 0.9 -0.2
Bilateral oophorectomy (both ovaries removed) 0.9 1.0 2.5 0.7 0.3 0.9 0.8 0.3 1.2 -1.6 1.0 1.5 -1.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.7 4.5 -0.8 1.2 2.1 1.7 1.6 2.0 0.7 0.3 -0.2 0.8 1.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 2.5 -0.4 -0.0 -0.6 1.6 0.1 1.1 -0.7 -0.1 0.1 -0.6 0.3
Qualifications: CSEs or equivalent 1.9 2.5 6.9 -2.0 -0.7 -1.3 -1.7 -0.9 -0.4 1.8 -1.6 -2.6 1.4 -1.9
Serious illness, injury or assault to yourself 0.5 0.6 1.2 -1.1 0.9 0.6 0.5 1.0 0.9 0.3 0.8 0.0 0.9 0.4
High blood pressure 0.3 0.9 2.7 -1.6 -0.4 -0.8 -0.5 -0.3 -0.3 1.1 -1.1 -1.5 0.8 -0.2
Hayfever, allergic rhinitis or eczema 1.1 2.4 6.0 0.6 2.1 1.3 2.3 1.6 2.4 -0.9 1.7 0.9 -0.4 1.0
Multivitamins +/- minerals 1.7 2.2 9.3 3.0 0.4 0.5 -0.2 -0.2 -1.0 -2.4 1.2 1.1 -2.2 0.1
Stomach or abdominal pain in last month 0.2 0.2 0.8 -0.9 -0.1 -0.1 0.2 0.0 0.7 -0.2 -0.0 -0.3 0.5 -0.8
Supplements: Glucosamine 0.5 0.7 1.7 1.3 0.3 -0.3 0.4 -0.1 -0.6 -1.2 1.3 1.3 -0.6 -0.2
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 -0.8 -1.3 -1.5 -0.9 -1.3 -1.2 0.7 -1.1 -0.5 0.1 -1.4
Medication: Atenolol 2.0 2.6 7.8 2.8 -0.0 0.3 0.8 -0.2 -0.4 -2.5 2.2 1.0 -2.7 -0.4
Medication: Levothyroxine sodium 2.7 4.6 7.8 -2.0 -2.0 -2.8 -2.6 -2.3 -1.8 2.0 -1.9 -1.4 2.5 -2.1
Sitting height 0.4 2.5 7.1 1.7 0.5 0.1 2.4 0.6 1.0 -1.6 2.7 1.8 -1.0 1.9
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 0.9 1.4 0.4 0.7 1.3 0.4 0.3 1.4 -0.7 -0.4 0.9
High blood pressure (mother) 1.0 1.4 4.1 -0.2 1.7 2.0 0.8 1.7 1.0 0.8 -0.2 -0.4 0.6 1.5
Body mass index (BMI) 1.0 4.3 16.2 -3.3 1.8 0.5 2.1 1.3 4.0 1.3 2.1 1.3 1.8 0.1
Impedance of leg (left) 0.3 1.6 5.9 1.9 -1.1 0.1 -0.6 -0.7 -2.4 -1.2 -0.9 -0.6 -1.7 -0.2
Leg predicted mass (left) 0.4 2.0 7.0 -1.6 0.4 -1.0 1.9 0.1 2.6 0.3 1.9 1.8 0.7 0.2
Trunk fat mass 0.4 1.9 5.9 -2.1 0.5 -0.6 1.5 0.0 2.4 0.4 2.2 1.2 0.7 -0.9
Waist circumference 0.7 2.5 11.4 -2.4 1.0 0.1 1.7 0.6 3.4 0.7 1.7 1.3 1.1 -0.1
Number of incorrect matches in round 0.5 0.8 2.3 0.9 1.2 1.5 0.0 1.2 0.4 -0.6 0.3 0.0 -0.7 1.0
Past tobacco smoking 2.4 4.4 12.4 3.2 -0.9 -0.8 1.0 -1.4 -0.4 -3.3 1.5 2.3 -3.5 -1.5
Alcohol usually taken with meals 1.1 1.8 4.6 1.6 -0.6 -0.7 -0.3 -0.6 -1.8 -1.6 1.6 2.1 -1.9 -0.1
Nervous feelings 0.5 1.0 3.8 1.9 -0.8 -0.7 -1.1 -0.6 -0.5 -1.2 -0.1 -0.7 -1.3 -0.7
Frequency of tenseness / restlessness in last 2 weeks 2.1 3.3 10.2 2.7 0.4 -0.1 2.0 0.4 0.1 -3.2 2.4 1.5 -2.5 0.2
Hearing difficulty/problems with background noise 2.0 3.1 9.1 1.6 1.9 1.4 2.1 1.8 2.0 -0.8 3.0 0.8 -1.0 1.8
Hair/balding pattern: Pattern 2 1.6 2.1 7.4 -0.8 1.6 1.4 1.9 1.7 2.7 0.6 -0.1 0.6 0.7 1.7
Had menopause 0.4 0.4 1.5 -0.5 1.2 0.9 0.5 1.1 0.2 0.2 -0.6 -0.3 0.1 0.7
Had other major operations 0.6 0.7 2.3 0.6 1.1 1.3 -0.4 1.0 0.0 0.2 1.5 0.3 0.6 0.7
Forced vital capacity (FVC) 0.2 0.7 1.8 0.5 -0.7 -0.7 1.3 -0.3 1.2 0.2 0.2 1.4 -0.2 1.3
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 6.8 0.0 1.4 2.1 2.2 1.8 2.6 0.3 1.2 0.3 0.4 1.8
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.0 1.0 -1.1 -0.8 0.1 -0.9 0.1 -0.8 0.5 -0.1 -1.4 -1.4
Qualifications: None of the above 0.7 1.5 5.5 -0.5 -0.9 -0.8 -1.3 -0.5 -1.3 1.4 -1.6 -2.4 0.7 -0.9
Financial difficulties in last 2 years 0.9 1.3 3.3 0.0 1.0 0.6 1.8 1.0 1.2 -1.1 1.4 1.1 -0.5 1.5
Mouth/teeth dental problems 0.6 0.9 4.2 -0.6 -1.2 -1.1 -0.9 -1.1 -0.7 0.7 -2.0 -0.0 0.5 0.0
Heart attack 1.4 1.8 4.8 0.6 -1.9 -1.2 -1.5 -1.8 -1.5 -0.3 -1.0 -0.5 -0.4 -2.2
Allergy 0.2 0.4 2.2 -0.1 -1.5 -0.2 -0.7 -0.8 -0.6 0.2 -0.7 -0.3 0.0 0.2
Pain all over the body in last month 1.2 1.3 3.4 1.1 0.6 0.5 0.6 -0.2 0.4 -1.6 1.8 1.6 -1.4 -1.0
Diabetes (self-reported) 1.4 2.1 7.0 -2.6 -1.4 -0.7 -1.2 -1.3 -0.1 1.2 -1.4 -0.7 1.4 -2.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 1.4 -1.2 -0.3 -0.6 -0.5 -0.5 -0.6 -0.2 -1.0 -0.6 -0.1 -0.7
Medication: Ramipril 1.0 1.2 2.7 -0.4 -1.0 -1.1 -1.4 -1.3 -1.5 0.3 -0.8 -1.3 0.6 -1.6
Medication: Simvastatin 0.1 0.1 0.3 -0.5 0.0 -0.1 -0.6 0.2 0.1 -0.3 -0.2 -0.3 0.4 0.2
Fluid intelligence score 0.1 0.3 0.9 -0.7 -0.3 -0.1 0.1 -0.6 0.1 0.2 0.1 0.8 0.4 -1.0
Illnesses of siblings 1.1 1.5 4.6 1.2 0.6 0.5 1.9 0.8 2.1 -0.6 0.6 1.7 -0.5 1.5
Neuroticism score 0.2 0.3 2.1 -0.1 -0.3 0.1 0.5 0.7 1.5 -0.5 0.5 0.2 -0.5 -0.1
Weight 0.6 2.8 9.7 -1.6 0.7 -0.7 2.4 0.5 3.1 0.0 2.5 2.2 0.4 0.2
Impedance of arm (right) 1.0 4.9 17.0 2.6 -2.1 -1.3 -2.3 -2.3 -4.1 -1.7 -0.7 -1.1 -2.1 -2.1
Arm fat percentage (right) 0.5 2.1 8.6 -2.9 0.4 -0.7 0.7 -0.2 2.3 1.0 1.4 0.5 1.3 -1.6
Trunk fat-free mass 0.4 2.2 6.7 -0.2 0.2 -0.9 2.4 0.3 2.5 -0.3 1.9 2.6 -0.2 1.2
Hip circumference 0.6 2.5 11.3 -1.9 1.1 -0.2 1.8 0.8 3.4 0.5 1.7 1.9 0.8 0.1
Time employed in main current job 0.8 0.9 2.5 -1.0 0.7 1.1 0.0 1.3 1.6 0.1 0.3 1.2 0.4 1.2
Alcohol intake versus 10 years previously 0.6 0.8 2.7 0.6 -1.0 -0.9 -0.8 -0.6 -0.5 -0.9 0.2 1.6 -1.2 -0.7
Father’s age at death 1.7 2.3 7.0 2.6 0.1 0.4 1.0 0.4 1.1 -2.0 1.6 1.9 -2.2 0.8
Worrier / anxious feelings 0.9 1.8 5.0 1.2 0.7 0.6 0.7 1.0 1.7 -1.8 1.0 2.2 -1.4 1.1
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.3 0.7 0.1 0.5 0.4 0.5 0.4 0.6 -0.7 0.7 0.8 -0.5 0.1
Falls in the last year 1.1 1.5 2.6 -0.7 1.6 0.7 1.4 1.4 0.9 1.1 1.3 -1.6 1.2 1.0
Hair/balding pattern: Pattern 3 0.4 0.6 1.4 0.5 -1.0 -1.2 -0.3 -1.1 -0.8 -0.4 -0.4 0.7 -0.3 -0.5
Number of live births 0.9 1.3 6.4 -2.5 -0.8 -1.3 0.2 -0.7 -0.3 1.4 -0.5 -1.0 1.4 -0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.3 4.2 0.5 -0.3 0.2 1.9 0.0 2.0 0.2 0.7 2.0 -0.2 1.5
Pulse rate 1.3 2.1 7.1 1.3 1.8 1.2 1.7 1.4 0.7 -1.5 2.7 0.5 -1.3 0.6
Happiness 0.4 0.5 3.6 0.5 -0.5 -0.4 -0.2 -0.1 -0.8 0.1 -1.9 -0.3 -0.2 0.0
Noisy workplace 0.7 0.8 4.1 2.0 -0.4 -0.4 0.4 -0.1 -0.8 -1.2 -0.0 0.6 -1.2 0.6
Qualifications: A levels/AS levels or equivalent 0.5 1.1 4.4 -0.9 0.9 0.5 1.4 1.2 0.5 -0.4 0.4 1.4 0.1 2.1
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 3.9 -1.2 0.8 0.3 0.7 1.0 1.7 2.0 -0.9 0.5 1.5 1.8
Mouth/teeth dental problems: Dentures 0.8 1.4 4.5 0.9 2.1 1.4 0.5 1.5 0.3 -0.5 1.9 -1.0 -0.7 -0.2
Asthma 1.0 2.0 4.2 -2.0 -0.4 -1.0 -2.0 -0.6 -0.9 1.8 -1.0 -2.0 1.7 -0.5
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 3.3 0.4 1.2 0.9 1.1 1.4 1.1 0.9 0.8 0.5 0.5 1.8
Medication: Cholesterol lowering 0.7 1.1 2.9 -0.7 -0.7 -0.2 -1.4 -1.1 -1.2 0.6 -0.7 -1.7 0.6 -1.5
Depression (self-reported) 0.9 1.0 2.3 1.5 0.8 0.9 1.3 0.8 0.9 -1.4 0.0 1.3 -0.9 0.3
Medication: Lansoprazole 0.2 0.2 0.8 -0.4 -0.3 -0.2 -0.9 -0.4 -0.4 0.5 -0.8 -0.0 0.4 -0.0
Prospective memory result 1.4 1.7 4.1 -0.8 1.9 1.8 0.5 2.0 1.2 0.8 -0.0 -1.1 0.7 1.6
Lung cancer (father) 3.7 4.3 10.6 -0.4 2.5 3.0 1.7 3.3 2.5 1.0 1.4 -0.8 1.3 2.7
Illnesses of mother 1.1 1.3 3.8 1.6 0.1 -0.4 1.0 -0.3 0.7 -1.9 0.6 1.5 -1.9 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.2 0.7 3.1 -0.1 -1.0 -0.5 1.1 -0.6 0.9 -0.2 -0.1 1.8 -0.7 0.5
Pulse wave Arterial Stiffness index 0.2 0.2 0.6 -0.4 -0.4 -0.2 -0.6 -0.6 -0.5 -0.2 -0.4 0.3 -0.2 -0.7
Impedance of arm (left) 0.8 3.8 15.0 2.4 -1.7 -0.7 -2.0 -1.9 -3.9 -1.4 -0.8 -1.2 -1.8 -1.8
Arm fat mass (right) 0.6 2.3 7.6 -2.5 0.7 -0.7 1.6 0.1 2.8 0.7 2.0 1.1 1.1 -0.9
Trunk predicted mass 0.4 2.2 6.4 -0.1 0.3 -0.9 2.4 0.3 2.5 -0.3 1.9 2.5 -0.1 1.2
Standing height 0.4 4.5 10.4 3.2 -2.1 -2.5 1.1 -1.7 -1.6 -2.6 1.3 2.3 -2.8 0.2
Length of working week for main job 0.8 0.9 2.7 -0.5 1.0 0.6 0.1 0.9 0.8 1.6 1.1 -0.5 1.4 0.8
Exposure to tobacco smoke at home 0.9 1.0 4.8 1.2 0.8 0.8 0.8 0.6 0.6 -1.1 2.2 -0.1 -1.0 -0.3
Breastfed as a baby 0.5 0.6 1.2 0.6 0.9 0.3 0.4 1.1 0.1 -1.0 0.9 0.5 -0.8 0.8
Tense / ‘highly strung’ 1.0 1.7 3.8 1.9 0.7 1.2 1.4 1.3 1.5 -1.7 1.1 0.6 -1.2 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.7 1.9 1.0 -0.5 -1.0 -0.6 -0.8 -0.1 -1.1 0.2 0.5 -1.4 -1.2
Hair/balding pattern: Pattern 4 0.5 1.2 3.2 -1.4 0.1 0.6 -1.4 0.1 -1.2 1.8 -0.6 -1.0 1.6 0.2
Birth weight of first child 1.0 1.8 5.7 1.5 1.0 0.6 2.4 0.9 0.5 -1.4 2.0 1.0 -1.4 0.2
Peak expiratory flow (PEF) 0.5 1.1 3.3 0.8 0.2 1.1 1.8 0.5 1.3 0.2 1.5 1.1 -0.1 1.1
Pulse wave reflection index 1.2 1.4 4.9 -1.1 -0.1 0.6 -1.0 -0.3 -0.6 2.0 -1.4 -1.3 2.2 -0.2
Ever highly irritable/argumentative for 2 days 0.7 0.8 1.7 0.2 -1.3 -1.3 1.0 -1.0 1.0 -0.6 0.0 1.2 -0.9 -0.5
Loud music exposure frequency 0.4 0.4 1.1 -0.9 -1.1 -0.8 0.5 -0.8 0.2 0.1 -0.6 -0.8 -0.1 -0.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 1.8 -1.2 0.1 -0.5 0.2 -0.2 0.6 0.0 -0.3 1.3 0.2 0.2
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.8 -0.3 -0.7 -0.9 -0.0 -0.5 -0.5 0.2 -0.3 -0.2 0.2 -0.5
Blood clot in the leg (DVT) 0.4 0.5 1.4 -0.0 1.2 0.2 0.1 0.9 0.5 0.7 -0.6 1.1 0.8 0.3
Medication: Paracetamol 0.2 0.3 1.2 -0.9 -0.0 -0.2 0.1 0.2 1.1 0.6 0.7 0.2 0.7 -0.2
Headache pain in last month 0.9 1.5 3.4 -0.3 1.1 0.3 1.2 1.5 0.8 1.6 -1.2 -0.9 1.7 1.8
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 3.2 0.9 0.1 -0.5 0.5 0.4 1.0 -0.8 0.9 1.8 -0.9 0.5
Glaucoma (self-reported) 1.5 1.8 4.6 -2.2 0.0 0.4 -0.9 -0.1 -0.0 1.9 -1.8 -2.1 1.7 0.3
Gout (self-reported) 2.7 3.8 8.5 -0.9 -2.1 -2.1 -2.9 -2.1 -2.1 2.2 -1.0 -2.2 0.9 -1.6
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 8.6 -1.2 -1.9 -2.9 -2.0 -2.3 -1.2 1.1 -2.0 -0.3 1.2 -2.1
Medication: Amlodipine 0.7 1.0 2.8 -0.2 1.1 0.9 1.4 1.6 1.0 0.2 -0.4 -0.7 0.5 1.7
Medication: Ventolin 100micrograms inhaler 0.4 0.6 2.7 0.5 -0.5 -1.1 -0.1 -0.4 0.1 -0.9 1.6 0.5 -0.6 -0.3
Birth weight 1.2 2.6 6.1 2.3 0.7 0.1 1.6 0.8 -0.3 -1.4 2.5 2.3 -2.2 1.1
Chronic bronchitis/emphysema (mother) 4.0 4.6 11.5 -0.7 -2.9 -2.6 -2.5 -2.6 -2.4 0.7 -2.0 -0.5 0.2 -3.4
High blood pressure (siblings) 2.2 3.2 6.5 -1.9 -1.4 -1.5 -1.8 -1.9 -2.5 1.1 -1.6 -2.2 0.5 -2.4
Forced vital capacity (FVC), Best measure 0.1 0.5 1.7 0.2 -0.7 -0.4 1.0 -0.2 0.6 -0.2 -0.2 1.3 -0.6 1.1
Body fat percentage 0.5 2.1 7.8 -2.8 0.8 -0.1 1.3 0.3 2.6 0.8 1.6 0.7 1.2 -0.9
Leg fat percentage (right) 1.0 3.8 13.3 -3.4 1.8 0.7 1.7 1.4 3.6 1.4 1.5 0.7 1.8 0.2
Arm fat-free mass (right) 0.7 3.6 13.4 -1.2 1.1 -0.2 3.0 1.2 3.7 0.3 1.9 2.5 0.5 1.8
Exposure to tobacco smoke outside home 1.0 1.3 2.6 -0.1 1.4 0.6 1.5 1.4 1.1 1.1 1.6 0.7 0.9 1.4
Comparative body size at age 10 0.1 0.2 0.7 0.8 0.1 -0.1 0.1 -0.4 -0.7 -0.1 0.8 -0.3 -0.1 -0.4
Number of full brothers 0.5 0.6 1.9 0.8 1.0 0.3 1.1 0.7 0.9 0.1 1.4 -0.2 -0.2 0.4
Worry too long after embarrassment 0.4 0.6 2.4 0.4 -1.5 -1.6 -0.1 -0.6 0.1 -0.7 0.4 -0.0 -0.7 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 2.8 1.4 -0.0 -0.1 0.1 -0.4 1.1 -1.5 1.7 0.8 -1.2 -0.6
Wheeze or whistling in the chest in last year 0.6 1.0 3.6 -0.5 1.1 0.5 1.1 1.2 0.7 0.4 1.5 -1.9 0.2 0.3
Number of children fathered 2.0 2.2 7.0 -2.7 0.9 1.0 0.3 1.4 2.2 1.8 0.0 -0.2 2.1 1.2
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 2.5 0.9 -1.2 -1.0 -1.5 -1.3 -1.6 -0.6 -0.2 0.7 -1.3 -1.2
Age at first live birth 0.6 1.1 3.0 -0.3 0.4 1.1 0.9 1.0 1.2 -0.2 0.9 1.7 0.1 1.7
Pulse wave peak to peak time 0.1 0.1 0.5 0.7 -0.0 -0.1 0.5 0.3 0.2 -0.1 0.3 0.0 -0.1 0.6
Health satisfaction 1.5 1.9 5.7 2.4 1.2 1.1 1.2 1.2 0.4 -1.9 1.6 0.8 -1.6 0.8
Shortness of breath walking on level ground 0.5 0.6 1.5 -0.0 0.9 0.2 1.2 1.0 1.1 -1.2 -0.2 0.9 -0.6 0.3
Qualifications: College or University degree 0.3 1.0 3.7 0.3 0.3 0.4 1.0 0.9 0.2 -0.5 1.4 1.9 -0.2 1.5
Eye problems/disorders: None of the above 1.4 1.6 4.8 2.2 -0.5 -0.9 -0.1 -0.4 -0.2 -1.9 0.5 2.1 -1.9 0.4
Mouth/teeth dental problems: Loose teeth 1.1 1.3 3.6 1.7 1.0 0.8 0.9 0.7 0.7 -1.9 0.9 0.9 -1.4 1.0
Emphysema/chronic bronchitis 0.2 0.2 0.9 -0.5 0.1 -0.6 -0.3 0.2 -0.4 0.6 0.9 -0.1 -0.1 -0.5
Medication for pain relief, constipation, heartburn 0.3 0.5 1.6 1.0 -0.4 0.0 0.2 -0.5 -0.5 -1.3 -0.4 0.7 -1.1 0.0
Neck or shoulder pain in last month 1.2 1.7 3.4 -0.8 -0.9 -1.6 -1.7 -0.8 -1.7 1.0 -1.9 -1.1 1.7 -0.0
Medication: Blood pressure 0.3 0.5 2.9 -0.5 0.0 0.2 0.0 -0.0 -0.4 0.7 -0.9 -1.7 0.8 -0.0
Angina (self-reported) 0.6 0.8 2.9 0.4 -1.0 -0.5 -0.9 -1.3 -0.8 -0.6 0.1 0.6 -0.3 -1.7
Migraine (self-reported) 0.9 1.1 4.7 0.2 -0.5 -0.3 -0.9 -0.5 -1.9 1.0 -2.2 -0.6 0.7 -0.1
Medication: Ibuprofen 0.7 0.8 2.7 0.4 0.7 0.6 1.1 0.9 1.2 0.5 0.8 0.9 0.4 1.6
Medication: Allopurinol 3.0 4.0 8.6 -1.7 -2.1 -1.8 -2.4 -1.7 -1.4 2.9 -1.5 -2.9 1.6 -1.1
Medication: Omeprazole 0.2 0.3 1.6 -0.0 0.1 0.4 0.3 0.1 0.1 0.8 -0.6 -1.3 0.2 -0.4
Medication: Seretide 50 evohaler 0.4 0.5 1.5 0.4 -0.4 -0.7 -0.8 -0.5 -1.2 0.9 -0.8 -0.0 0.8 -0.1
Mean time to correctly identify matches 1.1 2.2 5.3 1.8 1.1 0.4 0.8 0.8 0.6 -1.8 2.3 2.0 -2.2 -0.4
Heart disease (mother) 0.8 1.0 2.7 -1.5 -0.3 0.2 -0.6 0.1 -1.1 1.6 -0.6 -1.3 1.5 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.3 1.3 -0.9 -0.5 -0.2 -1.2 -0.4 0.4 0.6 -0.5 -0.3 0.6 0.0
Whole body fat mass 0.5 2.1 7.2 -2.3 0.7 -0.5 1.5 0.3 2.7 0.6 2.0 1.1 1.1 -0.6
Leg fat mass (right) 1.0 3.8 13.9 -3.4 1.5 0.0 2.1 1.1 3.7 1.1 1.7 1.2 1.7 0.1
Arm predicted mass (right) 0.6 3.0 10.6 -1.2 1.0 -0.3 2.8 1.1 3.3 0.4 2.0 2.1 0.5 1.5
Pulse rate, automated reading 2.1 6.9 18.3 4.2 0.4 -0.5 1.6 0.2 -0.4 -4.3 3.8 2.3 -4.2 -0.5
Alcohol intake frequency. 0.7 1.6 5.1 0.0 -2.2 -2.1 -0.5 -2.1 -0.6 -0.5 -0.3 -0.1 -0.7 -1.6
Comparative height size at age 10 0.4 2.4 8.4 2.9 -0.1 -0.1 2.5 -0.1 -0.7 -1.8 1.0 0.6 -2.4 0.8
Number of full sisters 1.3 1.6 4.5 0.5 -1.2 -1.8 -1.8 -1.5 -2.1 -0.3 -0.4 0.9 -0.2 -1.3
Suffer from ‘nerves’ 1.1 1.7 4.0 1.8 -0.2 0.0 0.5 0.4 1.5 -1.7 1.8 1.6 -2.0 0.1
Overall health rating 0.2 0.4 1.8 0.5 0.5 0.1 0.1 0.3 -0.1 -0.1 1.1 -1.4 0.5 0.2
Chest pain or discomfort 0.2 0.2 0.9 0.3 -0.4 -0.6 -0.4 -0.4 -0.3 -0.4 -0.1 1.0 -0.5 -0.3
Had major operations 0.2 0.3 0.9 0.2 0.6 0.2 -0.2 0.9 0.5 0.5 -0.2 -0.6 0.7 0.8
Age at last live birth 2.0 2.9 8.8 -0.7 1.4 1.7 2.3 2.0 3.0 0.3 0.4 0.5 0.8 2.8
Family relationship satisfaction 0.4 0.5 2.3 1.5 -0.1 0.1 -0.2 -0.2 -0.6 -0.6 -0.2 1.1 -1.0 -0.4
Leg pain on walking 0.6 0.7 2.2 1.5 0.9 -0.0 0.9 0.8 0.6 -1.0 0.6 0.9 -0.3 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 3.3 -0.5 1.3 1.4 1.6 1.1 1.8 -0.7 1.7 0.3 -0.2 1.0
Commuting to job workplace: Car/motor vehicle 1.5 1.7 5.6 -2.4 0.4 -0.2 0.1 0.5 1.4 1.7 -2.1 -0.2 1.7 0.6
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 5.2 1.0 -1.3 -0.5 -1.7 -1.4 -2.3 -0.1 -1.0 -1.5 -0.5 -1.3
Medication: Aspirin 0.2 0.3 1.1 -0.3 0.6 0.6 -0.1 0.5 -0.4 0.4 1.0 -0.6 0.2 -0.5
Supplements: Vitamin C 0.3 0.4 3.2 -0.7 -0.2 -0.4 -1.8 -0.4 -0.0 0.2 0.5 -0.2 0.0 -0.0
Knee pain experienced in last month 0.3 0.5 1.3 0.3 0.5 -0.2 0.4 0.5 -0.0 1.2 1.1 -0.7 1.1 0.7
Hypertension (Self-reported) 0.5 1.3 5.6 -2.4 -0.2 -0.8 -0.4 -0.3 -0.0 1.4 -1.4 -1.5 1.2 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 -0.1 -0.2 -0.1 -0.6 -0.1 -0.2 0.5 -0.6 0.0 -0.1 -0.4
Illnesses of father: Heart disease 0.6 0.8 4.9 0.5 1.0 1.2 0.8 0.8 0.2 -0.4 2.2 -0.1 0.1 0.3
Illnesses of siblings: Diabetes 3.8 4.6 7.2 -1.9 -1.7 -1.4 -2.6 -1.7 -2.7 2.1 -2.6 -2.5 1.8 -2.3
Smoking status: Previous 1.5 2.2 7.1 -2.7 0.1 -0.1 -1.2 0.6 -0.4 2.2 -1.5 -1.1 2.4 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 3.7 1.4 -1.2 -1.3 0.9 -1.1 -0.9 -1.9 0.8 1.0 -1.8 -0.5
Whole body fat-free mass 0.4 2.4 8.0 -0.9 0.5 -0.8 2.4 0.3 2.8 -0.0 2.0 2.4 0.3 0.9
Leg fat-free mass (right) 0.4 2.0 6.9 -1.3 0.4 -1.0 2.0 0.1 2.6 0.1 2.0 2.0 0.5 0.2
Arm fat percentage (left) 0.5 2.1 7.5 -2.7 0.7 -0.4 1.0 0.1 2.6 0.9 1.7 0.7 1.2 -1.4
Average weekly red wine intake 2.1 3.1 11.1 1.8 0.6 -0.2 1.2 0.3 -1.1 -2.4 3.3 2.2 -2.5 0.2
Handedness (chirality/laterality): Left-handed 1.0 1.2 4.2 -0.2 -0.9 -0.7 -1.9 -0.9 -2.0 0.3 -0.3 -1.1 0.7 -1.3
Mood swings 0.6 1.0 3.0 0.9 0.7 0.9 1.7 1.5 1.1 -0.7 0.3 0.7 -0.4 1.3
Loneliness, isolation 0.7 1.0 4.3 2.1 -0.7 -0.5 0.9 -0.0 -0.1 -0.8 1.0 1.1 -1.4 0.2
Long-standing illness, disability or infirmity 0.3 0.5 1.3 -0.2 1.1 0.3 -0.2 0.8 0.2 0.7 0.8 -1.1 0.8 0.6
Ever had bowel cancer screening 0.6 0.7 2.6 -0.7 0.9 0.6 -0.6 0.8 -0.1 0.9 0.5 -1.6 1.1 -0.0
Diabetes diagnosed by doctor 1.2 2.0 7.8 -2.8 -0.9 -0.5 -0.7 -1.1 0.4 1.4 -1.4 -1.4 1.7 -1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.7 1.5 0.9 1.0 1.0 1.0 1.2 -0.7 -0.1 0.2 -1.2 -0.0 0.7
Friendships satisfaction 0.2 0.3 1.1 0.5 -0.6 -1.0 -0.1 -0.1 -0.3 0.6 -0.1 -0.6 -0.5 -0.3
Qualifications: nursing, teaching 1.6 2.5 4.9 1.3 2.0 2.2 1.7 1.6 1.2 -1.5 2.2 1.4 -0.6 0.9
Commuting to job workplace: Walk 1.6 1.8 3.3 1.8 -1.6 -0.7 -0.3 -1.5 -1.5 -1.6 -1.2 -1.0 -1.1 -1.5
Eye problems/disorders: Cataract 0.6 0.6 4.3 0.4 0.6 2.1 0.1 0.2 0.5 -0.4 1.4 0.3 0.2 0.0
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 5.5 0.1 1.3 1.5 0.8 1.6 1.9 -0.0 2.3 0.7 0.3 1.4
Medication for cholesterol 0.5 0.8 1.8 1.3 1.2 0.9 1.1 1.1 0.1 -0.6 0.9 0.4 -1.2 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.9 2.0 -0.6 1.3 1.4 1.4 1.2 0.6 -0.2 0.6 -0.3 -0.2 1.0
Back pain experienced in last month 0.6 0.9 1.8 -0.6 -1.0 -1.1 -0.4 -1.2 -0.7 0.9 -1.3 -0.8 1.1 -0.9
Mineral and other dietary supplements 2.5 3.4 11.6 -2.7 -1.3 -0.7 -0.4 -0.5 0.6 2.5 -3.4 -2.0 2.4 0.0
Breast cancer (self-reported) 0.6 0.7 4.1 -0.4 -0.2 0.4 -2.0 0.1 -0.9 1.1 1.0 -0.6 0.5 0.3
Asthma (self-reported) 0.8 1.6 3.7 -1.8 -0.2 -1.0 -1.8 -0.5 -0.7 1.6 -0.9 -1.9 1.5 -0.4
Osteoporosis (self-reported) 1.9 2.4 5.7 -0.4 -1.5 -1.6 -2.2 -1.7 -2.4 -0.0 -1.0 -1.7 -0.0 -2.0
Osteoarthritis (self-reported) 0.2 0.3 1.0 -0.7 0.5 -0.1 0.6 0.1 1.0 0.5 -0.8 -0.1 0.2 -0.4
Medication: Aspirin 0.3 0.4 1.5 -0.0 0.9 1.0 0.5 0.8 0.3 0.1 1.2 -0.2 0.0 -0.1
Medication: Gliclazide 0.6 0.7 2.5 -1.1 0.3 -1.1 -0.2 -0.0 -0.2 1.1 -0.8 -0.9 1.6 -0.1
Illnesses of father: None of the above (group 1) 1.2 1.5 2.9 0.5 -1.3 -1.7 -0.6 -1.3 -1.6 -1.4 -0.0 1.2 -1.4 -1.4
Smoking status: Current 2.0 3.1 9.4 -1.7 1.4 1.4 0.3 1.2 1.4 2.4 -0.7 -3.1 2.6 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 8.2 0.1 1.5 1.5 1.6 1.8 2.9 0.2 0.5 1.1 -0.2 1.9
Whole body water mass 0.4 2.4 8.1 -0.8 0.5 -0.8 2.4 0.4 2.9 -0.1 2.0 2.4 0.2 1.0
Leg predicted mass (right) 0.4 2.2 7.6 -1.3 0.5 -0.8 2.2 0.2 2.8 0.0 2.1 2.1 0.5 0.3
Arm fat mass (left) 0.6 2.4 8.3 -2.5 0.7 -0.5 1.6 0.2 2.9 0.8 1.9 1.3 1.1 -0.7
Number of self-reported non-cancer illnesses 1.0 1.7 3.7 -1.9 -0.3 -1.0 -1.3 -0.5 -0.8 1.7 -1.0 -1.8 1.4 -1.5
Average weekly champagne plus white wine intake 0.7 1.0 2.9 0.2 1.0 1.1 0.4 1.0 -0.2 0.9 -0.5 -1.2 1.3 1.7
Miserableness 0.2 0.4 1.1 0.3 -0.0 -0.1 1.0 0.5 0.7 -0.6 1.0 -0.1 -0.8 -0.1
Guilty feelings 0.8 1.2 2.7 -1.0 -1.7 -1.7 -1.1 -1.0 -0.3 0.2 -1.2 -1.2 0.5 -1.3
Wears glasses or contact lenses 0.5 0.5 1.2 1.0 0.7 -0.4 -1.0 0.3 -0.4 -0.4 1.1 0.3 -0.9 -0.8
Ever taken oral contraceptive pill 0.9 1.0 3.0 -0.4 0.4 0.9 1.3 0.4 1.6 -0.1 1.7 1.4 -0.0 0.2
Hearing aid user 1.1 1.2 4.9 0.4 -0.7 -0.8 -1.3 -1.1 -2.2 -1.1 0.2 0.4 -1.1 -1.3
Mother’s age at death 0.3 0.3 0.7 0.4 0.2 -0.4 -0.9 0.2 0.6 -0.9 0.7 0.4 -0.8 -0.2
Financial situation satisfaction 2.3 2.8 8.1 2.8 0.4 0.6 1.4 0.6 0.7 -2.5 1.8 2.0 -2.4 0.6
Tinnitus: Yes, now most or all of the time 0.8 0.9 3.2 1.2 0.1 0.0 0.3 -0.2 -0.2 -1.4 1.6 0.6 -1.8 -0.4
Commuting to job workplace: Public transport 0.3 0.3 1.1 0.9 -0.1 -0.1 -0.5 -0.1 -1.0 0.2 0.9 -0.3 -0.2 -0.6
Eye problems/disorders: Glaucoma 1.8 2.1 6.2 -2.4 0.3 0.7 -0.2 0.3 0.3 2.2 -1.1 -2.5 2.0 0.4
Medication: Blood pressure 0.1 0.2 0.8 -0.8 0.0 -0.3 -0.4 0.0 0.2 0.9 -0.2 -0.7 0.4 0.2
Pain type(s) experienced in last month: Hip pain 0.3 0.3 1.1 0.6 0.1 -0.8 -0.1 -0.3 -0.1 -0.9 0.8 1.0 -0.1 -0.2
Supplements: Fish oil (including cod liver oil) 1.7 2.2 6.4 2.5 1.4 1.1 -0.5 0.6 -0.7 -1.9 2.3 1.2 -1.7 0.3
High cholesterol (Self-reported) 0.3 0.5 1.9 -1.4 -0.6 -0.2 -0.9 -0.2 0.4 0.6 -0.4 -0.5 1.2 -0.3
Medication: Bendroflumethiazide 0.4 0.6 2.1 -0.5 -0.2 -0.5 -1.1 -0.1 -0.3 1.3 -0.5 -1.4 1.0 -0.1
Medication: Paracetamol 0.3 0.5 1.9 -0.0 0.4 0.2 0.7 0.5 1.2 -0.3 1.4 0.9 0.1 0.0
Medication: Lisinopril 0.4 0.6 2.6 0.5 0.6 0.9 1.2 0.6 1.6 -0.3 0.6 -0.3 -0.1 0.2
Medication: Atorvastatin 0.8 1.0 3.5 -1.5 -0.5 -0.0 -0.5 -0.6 -0.6 1.2 -0.3 -1.9 1.1 -0.9
Illnesses of father: High blood pressure 0.5 0.6 2.2 0.7 -0.3 0.2 0.9 -0.8 -0.7 -0.5 0.2 -1.5 -0.8 -0.8
Alcohol drinker status: Never 0.5 0.7 2.4 1.1 -0.1 0.1 -0.3 -0.8 -0.4 -1.6 0.3 0.5 -0.9 -1.2
Ever smoked 3.2 5.6 15.0 -3.4 1.5 1.6 -1.3 1.7 0.7 3.7 -1.5 -2.6 3.9 1.7
Basal metabolic rate 0.4 2.3 7.7 -1.1 0.3 -1.0 2.3 0.1 2.8 0.0 2.0 2.3 0.4 0.6
Leg fat percentage (left) 1.2 4.3 15.5 -3.4 1.9 0.9 2.1 1.6 3.9 1.2 1.8 0.7 1.7 0.3
Arm fat-free mass (left) 0.6 2.9 10.3 -1.3 0.8 -0.4 2.7 0.8 3.2 0.4 2.0 2.2 0.5 1.3
Number of operations (self-reported) 1.1 1.7 3.7 0.7 1.8 1.9 1.1 1.9 1.7 0.2 0.7 0.6 0.6 1.5
Average weekly beer plus cider intake 0.1 0.2 0.6 -0.4 0.3 0.5 0.5 0.2 0.7 -0.1 0.3 0.6 0.5 -0.2
Irritability 0.8 1.4 5.1 -1.2 0.8 1.3 1.5 1.5 2.3 0.3 -0.1 1.1 0.4 0.8
Risk taking 2.1 3.1 6.8 -1.5 1.9 1.8 1.1 2.1 2.6 1.9 -0.0 -0.4 2.1 2.1
Ever had prostate specific antigen (PSA) test 0.8 0.9 4.1 0.6 0.8 0.4 0.5 0.8 0.4 -1.2 0.9 2.0 -0.9 0.5
Fractured/broken bones in last 5 years 1.1 1.4 3.6 -1.9 -0.4 -0.7 -1.2 -0.5 -0.9 1.6 -1.9 -1.2 1.1 -0.3
Age started oral contraceptive pill 2.4 3.0 5.7 1.7 1.4 1.8 2.3 2.1 1.7 -0.9 2.4 0.6 -0.9 2.2
Diastolic blood pressure, automated reading 0.3 0.8 2.7 -1.4 0.4 -0.0 -0.4 0.5 1.6 0.5 1.6 0.2 0.6 0.0
Ever depressed for a whole week 1.0 1.3 3.2 -0.6 -1.6 -1.4 -0.8 -1.2 -0.4 1.2 -1.3 -0.8 0.4 -1.8
Unable to work because of sickness or disability 0.9 1.1 3.3 0.5 -0.8 -1.3 1.2 -1.0 -0.1 -1.8 0.7 1.3 -1.3 -0.6
Commuting to job workplace: Cycle 0.8 1.0 6.2 -1.0 -0.8 -0.8 -0.2 -0.3 -0.8 1.1 -0.3 -2.5 0.2 -0.5
Myopia 0.7 1.1 3.0 1.3 1.3 1.0 -0.4 1.5 -0.2 0.0 -0.3 -1.1 0.6 1.7
Vascular/heart problems diagnosed by doctor 0.5 1.3 3.2 1.8 0.8 1.0 0.8 0.7 0.2 -1.5 1.4 1.8 -1.1 0.4
Cholesterol lowering medication 0.4 0.5 2.3 -1.0 0.2 0.3 0.3 0.7 1.5 -0.0 0.2 0.4 0.9 1.0
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.7 -0.0 0.2 0.3 0.2 0.4 0.3 0.8 -0.8 -0.8 0.3 0.2
Pain experienced in last month 0.7 1.1 5.4 0.5 -0.2 -0.0 0.6 -0.3 -0.1 -1.6 0.7 1.5 -2.3 -1.0
Supplements: Calcium 1.3 1.4 4.8 1.1 -0.7 -0.6 -0.4 -0.5 -0.9 -2.0 0.8 1.7 -2.2 -0.7
Basal cell carcinoma (self-reported) 0.5 0.6 2.4 -0.1 0.1 0.4 -0.2 0.4 1.1 1.2 -0.8 -0.1 1.5 0.7
Heart attack/myocardial infarction (self-reported) 1.4 1.8 4.5 0.6 -1.9 -1.2 -1.5 -1.8 -1.6 -0.2 -1.1 -0.7 -0.4 -2.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.4 -0.3 1.2 0.3 0.1 0.9 0.6 0.8 -1.0 1.1 1.0 0.4
Heart disease (siblings) 1.0 1.3 4.0 -1.2 0.3 -0.2 -1.1 0.4 -0.9 1.5 -1.4 -2.0 1.5 -0.2
Alcohol drinker status: Previous 1.4 1.5 4.5 -0.5 -2.1 -2.0 -0.4 -1.7 -1.0 -0.4 -0.8 -0.3 -0.4 -1.7
Pack years of smoking 0.3 0.4 1.9 -0.5 -0.5 -0.3 -1.4 -0.4 0.4 0.5 -0.7 0.4 -0.1 -0.5
Impedance of whole body 0.6 2.8 11.2 2.5 -1.4 -0.3 -1.4 -1.2 -3.3 -1.3 -0.8 -0.9 -2.0 -1.0
Leg fat mass (left) 1.0 3.9 14.5 -3.1 1.5 0.1 2.3 1.2 3.8 1.0 2.0 1.3 1.6 0.2
Arm predicted mass (left) 0.6 3.1 11.8 -1.3 0.7 -0.4 2.7 0.8 3.4 0.4 2.0 2.5 0.5 1.4