Hub : Genes

RNF219

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.084	0.0350	0.00490	0.025	NA	0.021	NA	0.012	3.8e-03	NA	7.2e-03	NA	0.03600
2	GTEx	Adipose Visceral Omentum	0.156	0.0610	0.00510	0.026	NA	0.006	NA	0.013	1.6e-02	NA	1.4e-01	NA	0.06400
3	GTEx	Brain Cerebellar Hemisphere	0.367	0.1010	0.00022	0.015	NA	0.067	NA	0.100	1.3e-01	NA	8.5e-03	NA	0.00160
4	GTEx	Heart Left Ventricle	0.128	0.0435	0.00110	0.052	NA	0.018	NA	0.048	8.9e-04	NA	3.8e-02	NA	0.00140
5	YFS	Blood	0.018	0.0078	0.00520	0.014	0.011	0.014	0.011	0.011	1.6e-05	0.00013	1.5e-05	1e-04	0.00012
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.067	0.0350	0.00078	0.008	0.033	0.029	NA	0.014	9.1e-02	0.00260	4.4e-03	NA	0.03600

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	1.2	-1.1	1.1	-0.1	0.4	-0.4	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	-0.6	1.3	0.3	-0.3	0.7	0.8
Depressed Affect (Nagel 2018)	0.9	1.8	5.9	-1.9	-0.2	0.9	0.0	-2.4	0.6
Depression (Nagel 2018)	0.7	1.0	2.2	-1.5	1.3	1.2	-0.1	-0.9	-0.4
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.5	-0.0	-0.7	0.7	-0.2	0.5	0.6
Neuroticism (Nagel 2018)	0.4	0.9	3.3	-0.7	-0.7	0.4	0.9	-1.8	-0.1
Schizophrenia (2018)	0.4	0.8	2.2	0.1	0.8	0.4	-0.6	1.2	1.5
Schizophrenia vs Biploar Disorder	0.7	1.0	2.3	-0.3	-0.6	0.7	-1.5	1.3	0.9
Worry (Nagel 2018)	0.5	1.0	3.5	-0.0	-0.8	-1.2	0.8	-1.9	0.3
Alzheimer’s Disease (in mother)	0.5	0.6	2.3	0.5	-0.3	0.2	0.2	0.8	-1.5
Alzheimer’s Disease (in father)	0.4	0.4	1.8	0.3	-0.0	0.2	0.5	0.4	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.0	2.9	1.2	-0.4	0.3	0.2	1.3	-1.7
Crohns Disease (2017)	0.6	1.4	1.9	1.4	0.0	1.4	-1.2	1.3	-1.1
Irritable Bowel Disease (IBD)	0.9	2.0	5.4	1.9	0.2	0.6	-1.5	2.3	-0.6
Ulcerative Colitis (UC)	1.2	2.3	7.9	1.8	-0.1	-0.5	-1.5	2.8	-0.6
Major Depression (MDD)	1.6	2.0	5.1	-2.3	0.1	1.9	-0.1	-1.7	0.1
Reaction Time	0.4	0.8	1.2	0.9	-1.1	-1.0	0.8	-0.6	0.9
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.9	0.3	0.1	-0.1	0.9	-0.8	1.7
Breast Cancer	0.3	0.7	1.2	-0.9	1.1	0.4	-1.0	-0.2	1.1
Ovarian Cancer	0.8	1.1	4.2	-0.3	-0.0	2.0	-0.8	1.2	0.2
Prostate Cancer	0.4	0.6	1.7	-0.3	-1.3	0.4	0.2	-0.4	1.2
Age at First Birth	0.3	0.4	1.2	0.2	0.6	-0.4	0.5	-1.1	0.5
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.8	0.3	-0.1	0.4	-0.6	-0.8
Body Mass Index (BMI) (2010)	0.4	0.5	1.3	-0.6	-0.9	0.6	-1.2	0.4	-0.1
Coronary Artery Disease (CAD)	2.7	3.2	7.1	2.7	-0.7	-1.1	-0.6	2.5	-2.0
Crohns Disease (2012)	0.4	0.7	1.7	0.1	0.2	1.0	-1.0	-1.3	-0.4
Mean Putamen Volume	2.3	2.7	5.6	-2.3	1.1	0.8	-0.7	-1.7	2.4
Fasting Glucose	0.5	0.6	1.4	-0.3	-0.9	-0.2	-1.2	0.5	-1.0
HbA1C	0.2	0.3	0.7	-0.5	-0.1	0.6	-0.4	-0.8	0.4
HDL Cholesterol	0.4	0.7	1.3	-1.0	-0.3	0.8	-0.6	-1.1	0.8
LDL Cholesterol	1.0	1.5	4.0	0.7	-1.4	-2.0	1.1	0.2	-1.2
Lupus	0.3	0.4	1.8	0.2	0.7	-0.0	1.4	-0.3	0.2
Neuroticism (2016)	0.9	1.3	3.5	-1.1	0.4	0.8	-0.5	-1.4	-1.9
Primary Biliary Cirrhosis	0.6	0.9	2.4	0.0	1.3	-0.4	1.6	0.1	0.9
Rheumatoid Arthritis	0.2	0.3	1.1	-0.3	1.0	-0.1	-0.0	-0.5	0.8
Schizophrenia (2014)	0.7	1.4	3.6	-0.5	1.0	0.8	-1.3	1.2	1.9
Triglycerides	0.4	0.6	2.5	0.3	0.5	-0.6	1.6	-0.3	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.7	0.3	-0.3	0.4	-0.4	1.3	-0.3
Ulcerative Colitis	0.5	0.7	1.9	0.3	0.2	-1.0	-1.0	0.6	1.4
Blood Eosinophil Count	0.1	0.9	1.9	-0.9	0.9	0.8	1.1	-1.4	-0.6
Blood Platelet Count	0.1	1.5	6.0	1.1	-0.0	0.4	-1.2	0.7	2.4
Blood Red Count	0.6	6.0	14.4	-3.5	1.9	-0.8	2.1	-3.8	1.1
Blood White Count	0.2	1.3	4.3	-0.3	-0.6	0.9	1.2	-1.0	2.1
Heel T-Score	0.3	2.6	8.1	-2.9	0.2	1.1	-1.1	-1.9	1.0
BMI	1.4	8.3	30.3	-5.5	0.8	0.7	1.1	-3.3	2.5
Height	0.2	4.1	8.5	-1.6	2.4	-1.9	2.9	-1.7	-1.2
Waist Hip Ratio (WHR)	0.4	1.8	3.8	1.4	-1.2	-0.4	0.1	-2.0	1.8
Systolic Blood Pressure	0.3	1.3	3.2	-0.0	1.8	-1.2	-1.1	0.9	1.1
Smoking Status	0.5	1.3	4.9	-0.7	-2.2	0.7	-1.0	0.3	0.8
Allergy or Eczema	0.8	2.2	6.3	-1.3	1.5	0.2	2.5	-1.0	1.4
Cardiovascular Disease	0.3	0.9	2.4	-1.2	1.0	-0.5	1.6	-0.4	0.4
Hypothyroidism (self reported)	0.4	1.0	1.9	0.6	0.0	-1.1	1.4	-1.1	-1.1
Respiratory disease	1.7	3.8	11.3	-3.4	-1.0	1.7	0.3	-2.3	1.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.4	-1.8	1.2	1.0	-0.2	-0.2	-0.9
Lung FEV1/FVC ratio	0.4	2.2	7.8	1.4	-0.0	-2.8	0.8	-0.0	-1.6
Lung FVC	0.8	4.0	12.3	-1.3	2.2	3.5	-1.2	1.7	-1.0
Neuroticism	1.0	2.5	9.6	-1.4	-1.7	0.1	0.7	-3.1	-0.1
Chronotype (morning person)	0.5	1.2	2.9	0.8	0.6	0.3	-1.5	1.7	0.9
Hair Pigment	0.3	7.9	33.3	-5.8	1.5	2.6	-1.1	1.3	-1.6
Tanning	0.0	0.3	0.7	-0.8	-0.4	0.1	-0.4	-0.8	-0.6
Hand grip strength (left)	0.9	2.3	6.2	-1.5	0.8	1.3	-1.1	-2.5	-1.2
Number of treatments/medications taken	0.4	0.7	3.1	-1.8	0.4	0.7	0.7	-0.2	-0.3
Average weekly spirits intake	1.1	1.3	2.8	-1.2	-0.8	1.4	-1.7	-1.0	-0.3
Sensitivity / hurt feelings	0.5	0.8	2.4	-0.3	0.6	0.1	1.6	-1.0	-1.0
Frequency of depressed mood in last 2 weeks	1.0	1.3	4.3	-2.1	0.5	0.9	-1.2	-0.9	-0.5
Hearing difficulty/problems: Yes	0.9	1.4	3.3	-1.2	0.1	0.4	1.8	-1.7	0.6
Relative age of first facial hair	0.6	1.2	3.1	0.5	0.6	1.0	0.1	-1.7	-1.8
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.6	0.3	-0.0	1.0	1.2	-1.3	0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	4.1	0.4	-1.3	0.3	0.8	-0.5	2.0
Ever had hysterectomy (womb removed)	1.7	2.0	5.5	-1.3	1.6	-0.2	2.4	-0.5	1.3
Systolic blood pressure, automated reading	0.8	2.2	6.2	0.3	1.4	-2.5	-0.3	0.4	2.2
Eye problems/disorders: Diabetes related eye disease	1.7	1.8	4.4	2.1	-0.1	-1.2	1.2	1.7	-0.9
Angina	0.2	0.2	0.8	-0.2	-0.7	-0.9	0.2	-0.0	-0.4
Medication for hormone replacement therapy	1.9	2.2	4.7	-0.4	-1.8	0.2	2.2	-2.1	-0.5
Vitamin and mineral supplements	0.9	1.3	3.2	0.8	-1.6	-1.1	-0.4	-0.1	-1.8
Supplements: Zinc	0.3	0.3	0.7	-0.0	0.2	-0.5	-0.8	-0.6	-0.8
Medication: Co-codamol	0.3	0.3	0.8	-0.1	0.2	0.9	-0.8	-0.7	0.2
Medication: Metformin	1.5	2.1	4.6	-2.1	-1.2	1.9	-1.3	1.0	-0.5
Diabetes (father)	1.4	1.8	3.6	-1.9	-0.5	0.9	-0.5	-1.6	1.8
Diabetes (mother)	1.1	1.3	3.7	-1.0	0.1	0.5	1.2	-1.3	1.9
Severe depression (siblings)	0.4	0.5	1.9	0.5	0.2	1.4	0.2	-0.1	0.8
Pack years adult smoking proportion	0.4	0.6	3.2	0.1	0.0	-0.1	1.8	-0.4	0.0
Impedance of leg (right)	0.5	2.3	10.6	3.3	0.7	0.8	-0.9	0.7	-0.7
Leg fat-free mass (left)	1.1	5.9	26.9	-5.2	0.0	0.3	1.5	-2.4	0.6
Trunk fat percentage	1.6	6.4	19.2	-4.4	-0.8	3.3	-0.6	-1.9	1.9
Hand grip strength (right)	0.7	1.8	7.7	-1.6	0.5	-0.0	-0.4	-2.8	-0.4
Townsend deprivation index at recruitment	0.6	0.8	1.8	0.2	-1.4	0.9	-1.2	0.7	-0.2
Current tobacco smoking	0.6	1.0	3.7	0.7	-1.9	0.4	0.0	-0.2	-1.1
Average weekly fortified wine intake	4.2	4.9	17.0	-4.1	0.0	1.3	-0.9	-3.0	0.8
Maternal smoking around birth	1.6	2.4	6.5	-1.1	-1.1	2.5	-1.8	0.4	-1.3
Fed-up feelings	1.5	2.8	8.8	-2.2	0.6	1.3	0.9	-3.0	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	6.3	-2.5	-0.0	2.5	-1.1	-0.9	0.8
Relative age voice broke	0.6	0.9	2.8	1.0	-0.1	-0.4	0.8	-1.7	-1.0
Taking other prescription medications	0.7	1.1	3.6	-0.9	-0.2	0.8	1.9	-0.9	-0.8
Age when periods started (menarche)	0.5	1.2	5.4	0.0	2.3	0.5	1.2	0.2	-0.5
Bilateral oophorectomy (both ovaries removed)	1.3	1.4	4.1	-0.7	2.0	0.2	1.8	-0.9	0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.6	9.0	-3.0	-0.6	1.7	-0.9	-1.6	0.6
Tinnitus: Yes, but not now, but have in the past	1.3	1.4	4.1	-0.4	-0.2	-1.7	-2.0	1.2	0.1
Qualifications: CSEs or equivalent	2.7	3.5	10.5	-1.6	0.5	3.2	-2.7	-0.4	-0.6
Serious illness, injury or assault to yourself	1.0	1.3	3.1	-1.2	1.8	-0.0	1.6	-0.6	0.3
High blood pressure	0.3	0.8	2.0	-1.3	0.5	-0.8	-0.4	0.5	1.4
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.2	-1.2	0.7	1.0	2.0	-1.3	0.7
Multivitamins +/- minerals	1.1	1.4	3.4	-1.0	1.6	-0.0	1.2	0.1	1.8
Stomach or abdominal pain in last month	0.7	0.9	2.5	-1.6	-1.0	0.9	-0.4	-0.8	0.6
Supplements: Glucosamine	0.1	0.2	0.8	-0.5	0.9	-0.1	-0.1	0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.8	-0.9	0.6	0.4	0.6	0.1
Medication: Atenolol	0.6	0.7	3.5	-0.3	0.1	-0.7	-0.0	1.9	0.5
Medication: Levothyroxine sodium	0.6	0.9	5.1	-0.2	0.0	0.4	0.3	-2.3	0.5
Sitting height	0.2	1.7	6.1	-2.5	0.1	0.1	0.8	-0.5	-1.7
Chronic bronchitis/emphysema (father)	1.1	1.3	3.3	-1.0	-1.5	0.3	0.4	-1.0	1.8
High blood pressure (mother)	0.7	1.0	5.9	0.2	0.2	-0.4	0.2	0.0	2.4
Body mass index (BMI)	1.6	6.8	22.2	-4.7	0.0	1.3	1.2	-2.7	2.9
Impedance of leg (left)	0.6	3.1	14.4	3.8	0.5	0.6	-1.2	1.1	-0.9
Leg predicted mass (left)	1.1	5.7	25.9	-5.1	-0.1	0.2	1.5	-2.4	0.7
Trunk fat mass	1.6	7.0	25.6	-5.1	-0.6	2.4	0.3	-2.5	2.1
Waist circumference	1.3	4.7	12.7	-3.6	-0.6	0.9	0.8	-2.5	2.7
Number of incorrect matches in round	1.8	3.0	8.7	-1.7	0.9	1.2	-0.6	-1.9	2.9
Past tobacco smoking	0.4	0.7	2.3	0.7	1.5	-0.4	0.7	-0.2	-0.7
Alcohol usually taken with meals	1.7	2.8	6.9	1.9	2.1	-1.4	2.6	0.0	0.2
Nervous feelings	0.2	0.4	0.7	0.7	-0.6	-0.7	-0.8	-0.1	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	6.2	-1.6	1.5	-0.6	1.8	-2.5	1.1
Hearing difficulty/problems with background noise	1.2	1.8	4.7	-0.8	-0.6	-0.6	2.2	-2.1	0.6
Hair/balding pattern: Pattern 2	0.6	0.7	2.0	-1.4	0.2	-1.3	-0.0	-0.7	0.0
Had menopause	1.0	1.3	3.3	1.3	-0.1	-0.7	1.3	1.8	0.8
Had other major operations	0.9	1.1	5.2	-0.6	2.3	0.2	0.5	0.9	-0.2
Forced vital capacity (FVC)	0.6	2.1	5.8	-2.4	1.2	1.4	-1.3	0.6	-1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	8.6	-2.9	0.1	1.3	-1.0	-0.8	0.8
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.3	-1.4	1.1	-1.0	1.8	-1.7	1.4
Qualifications: None of the above	1.1	2.3	8.9	-0.1	-1.6	-0.1	-1.3	3.0	-0.6
Financial difficulties in last 2 years	0.4	0.6	1.2	-0.2	-1.1	0.4	0.3	-1.0	0.9
Mouth/teeth dental problems	0.3	0.5	1.5	0.0	1.2	-0.3	0.0	0.6	-0.9
Heart attack	0.9	1.2	2.7	-1.3	0.0	0.1	0.4	-1.6	1.6
Allergy	1.0	2.3	5.7	1.6	-0.6	-1.5	-2.4	1.4	-1.0
Pain all over the body in last month	0.7	0.7	1.4	-0.6	-0.3	1.0	-0.4	1.2	1.1
Diabetes (self-reported)	0.9	1.4	5.7	-2.4	-0.2	1.5	-0.2	-0.4	-0.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	1.6	1.0	0.4	-0.1	1.3	0.7	-0.5
Medication: Ramipril	0.4	0.6	1.5	0.5	0.9	0.3	0.8	1.2	0.2
Medication: Simvastatin	0.7	1.1	5.0	0.1	1.0	-0.7	2.2	0.2	-0.0
Fluid intelligence score	0.3	0.7	1.3	-0.5	-0.1	0.3	1.1	-1.1	1.2
Illnesses of siblings	0.3	0.5	1.3	0.5	1.1	-1.0	-0.2	-0.5	0.1
Neuroticism score	0.9	1.9	6.7	-1.9	-0.8	0.6	0.5	-2.6	0.2
Weight	1.4	6.9	26.9	-5.2	0.4	0.7	1.7	-2.9	1.7
Impedance of arm (right)	1.0	4.8	7.8	2.1	1.0	2.7	-2.8	2.2	-1.8
Arm fat percentage (right)	1.8	7.3	23.0	-4.8	-0.1	2.8	-0.4	-2.2	2.8
Trunk fat-free mass	0.9	5.0	13.4	-3.7	0.7	-1.6	2.7	-2.5	0.1
Hip circumference	1.1	4.9	21.8	-4.7	0.2	1.1	0.6	-1.7	1.7
Time employed in main current job	0.4	0.4	1.4	-0.2	0.6	-0.2	-0.8	-0.5	1.2
Alcohol intake versus 10 years previously	0.7	1.1	2.9	-1.4	-0.8	1.7	-0.8	-0.7	0.3
Father’s age at death	0.8	1.1	3.5	-1.9	0.0	0.5	-0.8	-1.3	0.6
Worrier / anxious feelings	1.0	1.9	6.4	-1.0	-1.2	-0.4	1.3	-2.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.8	2.9	9.0	-3.0	-0.1	2.2	0.5	-1.8	0.3
Falls in the last year	0.8	1.1	2.6	-0.2	-1.1	0.8	1.4	-1.6	0.1
Hair/balding pattern: Pattern 3	0.3	0.4	1.0	0.3	-1.0	-0.8	-0.7	-0.2	0.1
Number of live births	0.5	0.7	1.6	-0.6	1.0	-0.6	1.3	0.1	0.8
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.7	-1.9	1.5	0.5	-0.7	0.1	-1.5
Pulse rate	0.8	1.3	4.2	-0.5	1.4	2.1	0.5	-0.9	-0.1
Happiness	0.6	0.8	2.4	0.2	-0.3	-0.6	1.6	-1.3	-0.1
Noisy workplace	0.7	0.9	2.2	-1.4	-0.1	0.3	-0.8	-0.7	1.5
Qualifications: A levels/AS levels or equivalent	1.5	3.4	5.8	-1.4	1.7	-2.0	1.3	-2.4	1.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	0.2	0.9	-0.1	-0.2	-0.6	1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	3.8	-0.7	-1.9	-0.2	-0.4	-0.9	-0.8
Asthma	1.1	2.1	4.1	-2.0	0.1	2.0	1.0	-1.8	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	3.4	-0.8	0.7	1.8	1.0	-0.7	-0.5
Medication: Cholesterol lowering	0.7	1.1	2.7	-1.0	1.5	0.3	1.6	-0.7	-0.4
Depression (self-reported)	0.4	0.5	1.6	-1.3	0.8	-0.5	-0.4	0.1	0.2
Medication: Lansoprazole	0.7	0.8	2.9	0.3	1.7	-0.3	0.4	-0.5	1.1
Prospective memory result	0.6	0.7	1.6	1.0	-0.9	-0.1	0.9	0.5	-1.3
Lung cancer (father)	0.8	0.9	2.5	0.5	0.8	-0.8	-1.1	1.6	-0.1
Illnesses of mother	0.7	0.9	3.1	-1.8	0.9	0.5	-0.4	-0.7	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	3.3	-1.1	1.5	0.5	-0.3	0.4	-1.8
Pulse wave Arterial Stiffness index	1.5	1.7	4.5	2.1	-1.0	0.0	1.5	0.5	-1.5
Impedance of arm (left)	1.3	6.1	12.6	2.2	0.4	3.2	-3.5	2.5	-1.5
Arm fat mass (right)	2.0	8.0	28.7	-5.4	-0.1	1.8	0.7	-3.0	2.7
Trunk predicted mass	0.9	4.9	13.2	-3.6	0.7	-1.7	2.6	-2.5	0.0
Standing height	0.2	2.0	4.6	-1.6	0.6	-1.1	1.3	-1.0	-2.1
Length of working week for main job	0.6	0.6	2.7	0.2	-0.6	-1.6	-0.1	-0.1	0.8
Exposure to tobacco smoke at home	1.4	1.6	3.2	-1.8	-0.7	1.1	-0.8	-0.9	1.8
Breastfed as a baby	0.3	0.3	0.9	0.6	0.6	-0.5	0.3	-0.1	-1.0
Tense / ‘highly strung’	0.9	1.5	5.4	-1.8	0.3	-0.3	0.1	-2.3	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	5.4	-0.8	0.1	0.5	2.3	-2.3	-0.2
Hair/balding pattern: Pattern 4	0.7	1.6	5.7	1.0	-1.5	0.5	-0.5	2.4	-0.4
Birth weight of first child	0.5	0.9	2.1	1.1	0.1	-0.0	0.8	1.3	-1.4
Peak expiratory flow (PEF)	0.4	0.9	1.6	-1.0	1.1	-1.2	-0.1	0.4	-1.3
Pulse wave reflection index	0.6	0.8	2.7	0.7	-1.6	-0.9	0.7	-0.1	-0.3
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.6	-0.6	0.5	-1.1	-0.6	0.1	-1.3
Loud music exposure frequency	0.4	0.4	1.2	-0.9	0.2	-0.1	1.1	-0.3	0.7
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.0	0.3	0.7	-0.9	1.7	-1.7	1.2
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	8.6	0.3	0.6	1.0	0.5	0.2	2.9
Blood clot in the leg (DVT)	0.7	0.8	2.3	0.0	1.5	-0.8	0.6	1.0	0.7
Medication: Paracetamol	0.8	1.3	2.8	-1.7	0.9	1.0	0.7	-1.5	0.4
Headache pain in last month	0.4	0.8	2.3	-0.7	1.5	-0.0	1.3	-0.3	0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	2.0	1.2	-1.3	-0.3	-1.4	1.0	0.5
Glaucoma (self-reported)	0.9	1.1	3.1	0.2	1.5	-0.4	0.9	0.1	1.8
Gout (self-reported)	0.5	0.7	2.8	0.5	0.2	0.5	1.7	-0.5	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.5	0.1	0.9	-0.1	0.4	-1.6	-0.3
Medication: Amlodipine	0.1	0.1	0.7	0.2	0.0	-0.1	0.9	0.1	0.3
Medication: Ventolin 100micrograms inhaler	0.4	0.6	2.3	-0.7	-0.6	1.5	-0.1	-0.3	0.1
Birth weight	0.2	0.5	0.8	-0.7	0.7	0.9	0.7	0.4	-0.8
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.2	-0.1	-0.2	1.1	0.3	-0.7	0.5
High blood pressure (siblings)	1.1	1.6	4.2	1.6	-0.5	-0.3	1.2	2.0	-1.0
Forced vital capacity (FVC), Best measure	0.3	1.2	2.0	-1.3	1.3	0.9	-0.6	0.6	-1.4
Body fat percentage	1.7	6.6	20.1	-4.5	-0.4	3.0	-0.2	-2.2	2.4
Leg fat percentage (right)	1.5	5.3	11.2	-3.3	0.2	1.8	0.7	-2.6	3.2
Arm fat-free mass (right)	1.0	5.2	15.7	-4.0	-0.5	-1.5	2.4	-2.6	0.8
Exposure to tobacco smoke outside home	1.0	1.3	3.1	-1.3	0.0	0.5	-1.8	1.5	-0.8
Comparative body size at age 10	0.4	1.1	2.3	-0.2	-1.0	0.8	-1.5	0.7	1.4
Number of full brothers	0.4	0.5	1.3	0.7	-0.7	0.7	-1.1	0.5	-0.3
Worry too long after embarrassment	0.5	0.8	2.1	1.2	-1.5	0.1	0.6	-0.8	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.4	-1.6	-0.3	-0.5	0.1	-1.0	-1.9
Wheeze or whistling in the chest in last year	1.6	2.8	8.1	-2.8	0.8	2.4	-0.0	-1.5	-0.2
Number of children fathered	0.4	0.5	1.7	-0.3	-0.2	-0.5	1.3	-0.6	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	8.2	0.3	2.9	-0.7	1.0	-0.4	0.6
Age at first live birth	0.5	0.9	1.9	0.2	1.4	-1.3	-0.7	1.0	-0.1
Pulse wave peak to peak time	1.4	1.7	5.1	-2.3	1.2	-0.0	-1.3	-0.6	1.3
Health satisfaction	0.8	1.0	2.5	-1.6	0.0	0.7	-0.8	-1.3	0.8
Shortness of breath walking on level ground	0.8	1.0	2.2	-1.5	0.4	0.9	-0.7	0.1	-1.5
Qualifications: College or University degree	1.9	6.0	16.2	1.5	2.7	-4.0	3.1	-0.1	0.5
Eye problems/disorders: None of the above	1.5	1.7	4.2	-0.3	-1.1	2.1	-1.5	0.7	-1.4
Mouth/teeth dental problems: Loose teeth	1.0	1.1	3.3	-0.3	-1.7	0.6	-1.8	-0.0	0.6
Emphysema/chronic bronchitis	1.3	1.5	4.8	-1.0	-1.5	2.2	-0.1	-0.8	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	2.0	0.3	-0.7	-0.6	-1.3	-0.6	1.4
Neck or shoulder pain in last month	2.3	3.3	9.4	-2.6	1.0	1.0	1.1	-3.1	0.8
Medication: Blood pressure	0.8	1.5	3.7	-1.9	0.9	0.9	0.1	-1.8	0.7
Angina (self-reported)	0.2	0.3	0.6	-0.5	-0.6	-0.8	0.1	-0.3	-0.5
Migraine (self-reported)	0.8	0.9	2.4	0.6	0.7	-0.8	-0.3	1.3	-1.6
Medication: Ibuprofen	0.8	0.9	2.9	-0.5	0.5	0.9	1.7	-0.5	-1.0
Medication: Allopurinol	0.5	0.7	1.7	-0.9	-0.3	1.3	-0.8	-0.3	-0.9
Medication: Omeprazole	1.1	1.3	3.5	-1.2	0.2	1.6	-1.9	-0.5	0.3
Medication: Seretide 50 evohaler	0.5	0.6	2.7	-0.2	-1.6	0.9	0.3	-0.3	-0.1
Mean time to correctly identify matches	0.3	0.5	1.3	0.3	-1.1	-0.9	0.4	-0.2	0.8
Heart disease (mother)	1.7	2.1	4.7	2.2	-2.2	0.2	-0.8	1.6	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.2	-0.3	-1.0	-1.0	-0.4	-1.5	-0.8
Whole body fat mass	1.8	7.7	27.6	-5.3	-0.0	2.0	0.7	-2.9	2.4
Leg fat mass (right)	2.0	7.9	25.1	-5.0	-0.1	1.5	1.1	-3.1	3.0
Arm predicted mass (right)	1.0	5.4	15.9	-4.0	-0.5	-1.4	2.4	-2.7	0.8
Pulse rate, automated reading	0.5	1.7	3.9	-0.1	-0.0	1.5	1.0	-1.7	2.0
Alcohol intake frequency.	0.9	2.1	4.0	0.2	-1.6	1.6	-0.7	2.0	-1.7
Comparative height size at age 10	0.3	1.4	4.4	-0.3	-0.5	-1.4	1.1	0.7	-2.1
Number of full sisters	1.4	1.7	4.3	1.2	0.2	-0.4	-0.5	2.0	-2.1
Suffer from ‘nerves’	0.4	0.6	1.7	0.1	-0.4	-0.5	0.8	-0.7	-1.3
Overall health rating	0.9	1.9	5.5	-2.3	0.5	1.9	-0.1	-1.1	1.1
Chest pain or discomfort	1.5	2.1	7.4	-2.0	0.9	2.7	0.2	-0.5	0.0
Had major operations	0.7	0.8	2.3	-1.5	0.2	0.3	1.1	-1.1	0.1
Age at last live birth	1.3	1.9	5.2	-0.0	2.3	-1.1	-0.9	2.0	0.1
Family relationship satisfaction	0.9	1.2	3.9	-0.7	-1.0	-0.2	1.1	-2.0	0.5
Leg pain on walking	1.0	1.2	4.4	0.8	0.2	1.1	-0.4	1.0	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.6	-0.1	0.4	-0.5	-0.6	-0.8	0.0
Commuting to job workplace: Car/motor vehicle	1.1	1.3	4.7	0.3	2.2	-0.3	1.7	-0.4	-0.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	0.5	-0.9	-0.4	1.3	-0.2	-0.3
Medication: Aspirin	0.6	0.8	2.9	0.3	-0.5	0.1	1.7	0.6	-1.1
Supplements: Vitamin C	0.8	1.0	3.5	-1.1	0.9	0.1	-0.3	-0.3	1.9
Knee pain experienced in last month	0.9	1.4	3.8	-1.9	0.4	2.0	-0.2	-0.2	0.6
Hypertension (Self-reported)	0.2	0.5	1.3	-1.1	0.5	-0.6	0.2	0.3	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.2	3.4	-1.4	1.9	-1.8	-0.7	-1.8	1.1
Illnesses of father: Heart disease	2.4	3.4	10.2	3.2	-1.6	-0.1	1.8	0.8	-1.9
Illnesses of siblings: Diabetes	3.5	4.3	12.2	-3.5	0.0	1.3	0.9	-3.0	1.5
Smoking status: Previous	0.4	0.6	1.2	-1.1	-0.9	0.4	-0.6	0.1	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.3	-0.4	-0.8	0.1	-0.0	-0.5	-1.1
Whole body fat-free mass	1.0	5.5	19.5	-4.4	0.3	-1.0	2.3	-2.6	0.4
Leg fat-free mass (right)	0.9	4.7	21.3	-4.6	-0.2	-0.2	1.5	-2.1	0.3
Arm fat percentage (left)	2.0	7.8	23.8	-4.9	-0.3	3.0	-0.7	-2.1	3.0
Average weekly red wine intake	0.2	0.4	0.7	0.5	0.2	-0.8	-0.8	0.6	-0.4
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.5	-0.2	-0.3	0.4	-1.6	-1.0	-1.2
Mood swings	2.4	4.4	12.0	-3.5	0.1	1.9	-1.6	-2.4	1.5
Loneliness, isolation	1.6	2.2	5.9	-1.2	-1.8	2.4	0.4	-1.5	0.2
Long-standing illness, disability or infirmity	1.0	1.6	3.6	-1.6	-0.7	1.9	0.5	0.0	-1.6
Ever had bowel cancer screening	0.8	0.9	1.9	0.9	-0.7	1.1	-1.4	1.1	0.3
Diabetes diagnosed by doctor	0.7	1.1	4.8	-2.2	0.7	1.1	0.0	-0.2	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.9	-1.1	1.0	1.4	0.2	-0.7	-0.3
Friendships satisfaction	2.2	2.7	12.4	-1.6	-0.5	0.3	0.7	-3.5	0.9
Qualifications: nursing, teaching	1.1	1.7	4.0	-0.1	0.1	-1.0	2.0	-2.0	-1.1
Commuting to job workplace: Walk	0.4	0.4	0.9	0.0	1.0	-0.8	-0.7	0.6	-0.0
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.0	0.5	-0.9	-0.6	-0.9	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.0	-0.2	-1.4	0.0	-0.7	0.6	-0.4
Medication for cholesterol	0.7	1.0	2.0	-1.0	0.6	1.0	-1.4	-1.3	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.6	3.0	6.5	1.4	0.5	-2.6	1.5	0.7	-2.5
Back pain experienced in last month	1.8	2.6	8.3	-1.5	0.6	1.0	2.9	-1.8	0.7
Mineral and other dietary supplements	0.7	0.9	3.9	-0.5	0.1	-1.0	-0.1	-2.0	-0.6
Breast cancer (self-reported)	0.3	0.3	0.9	-0.9	0.3	-0.4	0.3	0.6	0.6
Asthma (self-reported)	0.8	1.7	3.9	-1.7	0.1	2.0	0.8	-1.5	0.5
Osteoporosis (self-reported)	1.3	1.6	4.9	2.2	1.2	-0.2	1.1	1.3	-0.7
Osteoarthritis (self-reported)	1.0	1.4	2.6	-1.6	0.8	1.6	-0.0	-0.4	1.5
Medication: Aspirin	0.5	0.6	2.0	0.3	-0.9	-0.4	1.4	0.6	-0.7
Medication: Gliclazide	0.9	1.0	3.2	-1.8	0.4	-0.1	-1.0	1.1	0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.9	-1.4	1.1	0.1	-0.6	-0.4	0.3
Smoking status: Current	0.5	0.8	3.4	0.6	-1.9	0.5	0.1	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.9	-0.6	-0.5	0.9	-1.0	1.4	-0.1
Whole body water mass	0.9	5.4	19.6	-4.4	0.1	-1.0	2.2	-2.6	0.3
Leg predicted mass (right)	0.9	4.6	21.4	-4.6	-0.2	-0.2	1.4	-2.1	0.2
Arm fat mass (left)	1.8	7.6	27.7	-5.3	-0.4	1.9	0.5	-2.7	2.6
Number of self-reported non-cancer illnesses	0.7	1.2	2.8	-0.8	1.2	0.0	1.7	-0.7	1.2
Average weekly champagne plus white wine intake	2.4	3.3	8.1	0.1	2.8	-1.9	2.9	-0.2	-0.3
Miserableness	0.9	1.5	4.0	-2.0	-0.9	-0.7	-0.9	-1.7	0.4
Guilty feelings	0.4	0.6	3.0	0.5	-1.7	0.7	0.2	-0.0	0.0
Wears glasses or contact lenses	1.5	1.7	4.5	0.7	-0.4	-1.8	2.1	-1.0	0.6
Ever taken oral contraceptive pill	1.4	1.5	4.6	-0.2	-2.1	0.5	0.1	-1.6	1.3
Hearing aid user	0.3	0.4	1.1	0.7	0.2	-1.1	0.0	-0.6	-0.4
Mother’s age at death	0.8	1.1	2.1	1.0	1.3	-1.4	1.0	-0.0	-0.8
Financial situation satisfaction	0.8	1.0	2.8	-0.6	-0.8	1.3	-1.7	0.9	0.3
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	0.5	-0.7	-1.2	1.2	0.8	0.5
Commuting to job workplace: Public transport	1.1	1.3	6.8	-0.4	-2.6	-0.1	-0.1	-0.4	-0.8
Eye problems/disorders: Glaucoma	1.6	1.9	5.5	-0.0	1.6	-0.9	1.6	-0.3	2.3
Medication: Blood pressure	0.6	1.2	2.9	1.1	-0.1	-0.8	1.3	1.7	0.8
Pain type(s) experienced in last month: Hip pain	1.2	1.5	4.4	-0.8	0.9	2.1	1.2	-0.5	1.1
Supplements: Fish oil (including cod liver oil)	0.6	0.8	4.4	0.1	-0.0	0.7	-0.1	2.1	0.1
High cholesterol (Self-reported)	0.9	1.6	5.8	-0.3	1.9	-0.2	2.4	-0.2	0.6
Medication: Bendroflumethiazide	2.1	3.3	10.0	-3.2	0.9	0.9	-1.5	-1.0	2.2
Medication: Paracetamol	0.5	0.8	1.9	-1.3	-0.1	0.5	0.8	-1.4	-0.1
Medication: Lisinopril	0.3	0.4	0.7	0.0	0.8	-0.6	-0.4	0.6	0.8
Medication: Atorvastatin	0.4	0.5	0.8	-0.0	-0.4	0.6	-0.9	0.9	-0.8
Illnesses of father: High blood pressure	0.9	1.2	3.7	1.4	0.6	0.4	-0.6	1.9	-0.6
Alcohol drinker status: Never	1.1	1.3	5.7	0.5	0.3	-0.0	-1.0	1.0	-2.4
Ever smoked	0.3	0.6	2.5	-0.9	-1.6	0.1	0.2	-0.3	0.4
Basal metabolic rate	1.1	5.9	22.6	-4.8	0.1	-0.5	2.1	-2.8	0.7
Leg fat percentage (left)	1.3	4.6	10.5	-3.0	0.3	1.6	0.7	-2.2	3.2
Arm fat-free mass (left)	1.1	5.5	14.3	-3.8	-0.1	-1.4	2.9	-2.8	0.7
Number of operations (self-reported)	1.1	1.6	6.4	-2.5	0.3	0.7	1.4	-0.5	0.5
Average weekly beer plus cider intake	1.3	1.8	4.2	-0.5	-1.8	2.1	-0.2	-1.1	1.5
Irritability	4.8	8.2	23.1	-4.8	-0.1	3.5	-0.8	-3.6	-0.4
Risk taking	1.0	1.5	2.3	-1.1	0.4	1.4	1.4	-1.3	-1.5
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-0.7	0.8	1.1	0.7	0.6	-0.2
Fractured/broken bones in last 5 years	1.4	1.8	7.3	-1.1	2.7	0.4	0.9	-1.0	-0.2
Age started oral contraceptive pill	1.4	1.8	3.1	1.7	1.5	-0.7	0.0	1.5	1.8
Diastolic blood pressure, automated reading	0.5	1.7	8.1	-1.1	0.7	-0.4	-0.4	-0.1	2.9
Ever depressed for a whole week	1.6	2.0	4.8	-0.8	2.2	0.5	1.1	-1.5	1.6
Unable to work because of sickness or disability	0.6	0.8	2.7	-0.1	-0.6	1.1	1.6	0.7	0.1
Commuting to job workplace: Cycle	2.2	2.7	7.8	-0.6	-2.8	1.2	-2.2	0.9	-1.0
Myopia	0.3	0.4	1.1	1.0	0.1	-0.3	-0.1	-0.9	-0.7
Vascular/heart problems diagnosed by doctor	0.3	0.8	2.0	1.4	-0.7	1.1	-0.1	-0.1	-1.2
Cholesterol lowering medication	0.6	0.8	2.0	0.8	0.3	-1.0	1.4	1.1	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	5.4	-1.6	-0.7	1.4	-2.3	-0.9	0.5
Pain experienced in last month	1.4	2.3	5.7	2.4	-0.1	-1.7	-1.9	1.1	-0.4
Supplements: Calcium	1.6	1.8	6.7	2.6	0.5	-0.6	0.9	0.8	-1.3
Basal cell carcinoma (self-reported)	0.5	0.6	2.1	-0.8	-0.9	-0.1	0.0	-1.5	0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.5	-1.4	-0.1	0.0	0.3	-1.5	1.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.3	-0.1	1.5	-0.7	0.6	1.1	0.9
Heart disease (siblings)	1.6	2.0	4.3	-0.6	-1.3	1.7	-2.1	1.0	-1.3
Alcohol drinker status: Previous	1.4	1.5	4.1	-1.4	-2.0	1.4	0.3	0.5	-1.0
Pack years of smoking	0.3	0.4	2.5	-0.1	-0.1	-0.1	1.6	0.0	0.0
Impedance of whole body	0.8	4.3	10.1	3.2	0.2	2.0	-2.3	2.0	-1.4
Leg fat mass (left)	1.9	7.3	22.7	-4.8	0.0	1.3	1.2	-2.9	3.0
Arm predicted mass (left)	1.1	5.5	16.6	-4.1	-0.0	-1.3	2.7	-2.6	0.9