TWAS hub - RNF38

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.195	0.0570	9.2e-05	0.167	NA	0.125	NA	0.161	1.6e-09	NA	2.2e-07	NA	3.2e-09
2	GTEx	Artery Tibial	0.102	0.0318	2.5e-04	0.029	NA	0.074	NA	0.057	2.2e-03	NA	2.1e-06	NA	3.0e-05
3	GTEx	Cells Transformed fibroblasts	0.199	0.0460	2.3e-08	0.215	NA	0.170	NA	0.197	4.8e-16	NA	9.7e-13	NA	1.0e-14

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Number of treatments/medications taken	9.2	16.5	20.3	4.3	3.2	4.5
Medication: Bendroflumethiazide	8.6	13.0	15.8	3.7	3.1	4.0
Medication: Seretide 50 evohaler	7.5	8.6	13.8	2.3	3.7	2.6
Ever had bowel cancer screening	6.8	8.0	9.2	2.7	3.0	2.8
Schizophrenia (2018)	6.5	13.4	16.6	3.3	4.1	3.6
Had menopause	6.2	7.8	9.7	2.5	3.1	2.7
Number of self-reported non-cancer illnesses	5.8	10.0	11.0	3.1	3.3	3.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.2	6.2	7.2	2.7	2.3	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	5.1	16.1	16.5	-4.0	-4.0	-4.1
Medication for cholesterol	5.1	7.7	9.7	-2.8	-2.4	-3.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.0	10.6	11.1	-3.2	-3.3	-3.2
Average weekly beer plus cider intake	5.0	7.2	11.6	2.2	3.4	2.3
High blood pressure	4.8	13.5	15.7	3.3	4.0	3.7
Forced expiratory volume in 1-second (FEV1)	4.8	16.2	18.6	-3.8	-4.3	-3.9
Lung FEV1/FVC ratio	4.7	24.0	26.8	-5.0	-4.5	-5.2
Osteoarthritis (self-reported)	4.6	6.0	8.3	2.9	1.6	2.6
Bipolar Disorder or Schizophrenia	4.5	10.9	11.6	3.1	3.4	3.4
Cholesterol lowering medication	4.4	6.5	7.5	2.7	2.2	2.7
Taking other prescription medications	4.2	6.5	7.6	2.6	2.3	2.8
Asthma (self-reported)	4.2	8.3	10.2	2.6	3.2	2.8
Medication: Blood pressure	4.2	8.0	10.1	2.5	3.2	2.8
Diverticular disease/diverticulitis (self-reported)	4.1	4.8	5.3	2.1	2.3	2.2
Hypertension (Self-reported)	4.1	11.4	12.7	3.0	3.6	3.5
Vascular/heart problems diagnosed by doctor	3.9	10.6	14.1	-2.7	-3.8	-3.2
Primary Biliary Cirrhosis	3.7	5.3	7.1	2.7	1.7	2.4
Ever had hysterectomy (womb removed)	3.5	4.0	4.4	2.0	1.9	2.1
Wheeze or whistling in the chest in last year	3.5	6.3	6.8	2.5	2.6	2.5
Schizophrenia (2014)	3.4	7.5	9.0	2.5	3.0	2.7
Asthma	3.4	6.7	8.6	2.3	2.9	2.5
Medication: Simvastatin	3.3	4.8	6.3	2.4	1.6	2.5
Schizophrenia vs Biploar Disorder	3.2	4.2	4.3	2.0	2.1	2.1
Respiratory disease	3.2	7.1	7.8	2.6	2.6	2.8
Systolic blood pressure, automated reading	3.2	9.4	10.2	3.2	2.9	3.1
Illnesses of father: Heart disease	3.2	4.4	5.1	-2.1	-2.0	-2.3
Supplements: Fish oil (including cod liver oil)	3.2	4.2	4.5	2.1	2.1	2.0
Medication: Lisinopril	3.2	4.2	6.4	1.7	2.5	1.8
Peak expiratory flow (PEF)	3.1	7.1	7.6	-2.5	-2.7	-2.7
High cholesterol (Self-reported)	3.1	5.4	6.2	2.3	2.2	2.5
Age started oral contraceptive pill	3.1	3.9	5.3	2.2	1.1	2.3
High blood pressure (siblings)	3.0	4.3	5.4	2.3	1.9	2.0
Illnesses of siblings: Diabetes	2.9	3.6	4.2	1.9	1.7	2.0
Medication: Aspirin	2.8	3.6	5.3	1.7	2.3	1.7
Prospective memory result	2.7	3.4	3.6	1.8	1.9	1.8
Long-standing illness, disability or infirmity	2.7	4.1	5.1	2.0	1.7	2.3
Tinnitus: Yes, now most or all of the time	2.7	3.1	3.7	-1.9	-1.7	-1.7
Chronic bronchitis/emphysema (father)	2.6	3.1	4.6	1.3	2.1	1.7
Unable to work because of sickness or disability	2.6	3.4	5.0	2.2	0.6	2.2
Exposure to tobacco smoke outside home	2.5	3.4	5.1	2.0	1.0	2.2
Falls in the last year	2.4	3.2	5.0	2.1	0.5	2.2
Medication: Blood pressure	2.4	4.3	5.2	2.0	2.0	2.3
Osteoporosis (self-reported)	2.3	2.9	4.3	-1.3	-2.1	-1.7
Illnesses of siblings	2.2	3.0	3.5	-1.9	-1.6	-1.7
Medication for cholesterol, blood pressure or diabetes	2.2	3.6	4.5	-1.8	-1.7	-2.1
Medication: Atorvastatin	2.2	2.7	6.2	0.9	2.5	1.1
Average weekly spirits intake	2.1	2.6	2.7	1.6	1.6	1.6
Chest pain or discomfort	2.1	3.0	5.6	1.3	2.4	1.4
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	3.8	-1.9	-0.7	-1.8
Leg pain on walking	2.0	2.5	2.7	-1.7	-1.5	-1.6
Lung cancer (father)	1.9	2.2	2.7	1.4	1.4	1.6
Breastfed as a baby	1.9	2.4	3.1	1.8	1.1	1.7
Glaucoma (self-reported)	1.9	2.3	4.4	-1.1	-2.1	-1.1
Forced vital capacity (FVC), Best measure	1.9	7.1	7.4	-2.6	-2.7	-2.7
Number of full sisters	1.9	2.3	2.7	1.5	1.4	1.6
Type 2 Diabetes (T2D) (2012)	1.8	2.1	2.4	1.3	1.4	1.6
Systolic Blood Pressure	1.8	9.0	9.3	3.0	3.0	3.0
Medication: Co-codamol	1.8	2.1	2.6	1.4	1.3	1.6
Forced vital capacity (FVC)	1.8	7.0	7.8	-2.5	-2.8	-2.6
Leg fat percentage (right)	1.8	6.4	6.8	2.6	2.3	2.6
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.0	1.7	0.6	1.7
Medication: Aspirin	1.8	2.3	3.0	1.4	1.7	1.4
Happiness	1.7	2.0	2.2	-1.5	-1.3	-1.4
Diabetes (father)	1.6	2.0	2.7	-1.4	-1.7	-1.2
Alcohol usually taken with meals	1.6	2.7	3.8	-2.0	-1.2	-1.7
Diabetes diagnosed by doctor	1.6	2.6	3.2	1.3	1.8	1.7
Leg fat percentage (left)	1.6	5.9	6.2	2.5	2.3	2.5
Body mass index (BMI)	1.5	6.5	7.4	2.7	2.2	2.7
Ever highly irritable/argumentative for 2 days	1.5	1.9	2.4	-1.6	-1.0	-1.5
Average weekly red wine intake	1.5	2.2	3.1	-1.8	-1.1	-1.5
Mouth/teeth dental problems: Dentures	1.4	2.3	3.8	1.0	2.0	1.4
Pulse wave Arterial Stiffness index	1.4	1.6	2.4	1.5	0.9	1.3
Impedance of arm (left)	1.4	6.6	8.0	-2.8	-2.0	-2.8
Shortness of breath walking on level ground	1.4	1.7	2.9	-1.7	0.1	-1.4
Mineral and other dietary supplements	1.4	1.9	2.4	-1.2	-1.5	-1.3
Breast cancer (self-reported)	1.4	1.7	2.2	-1.5	-1.0	-1.4
Average weekly champagne plus white wine intake	1.4	1.9	2.2	-1.4	-1.5	-1.2
Eye problems/disorders: Glaucoma	1.4	1.7	3.3	-0.9	-1.8	-1.0
Reaction Time	1.3	2.6	2.8	-1.7	-1.5	-1.6
Severe depression (siblings)	1.3	1.5	2.3	-1.3	-0.7	-1.5
Waist circumference	1.3	4.6	5.3	2.2	1.9	2.3
Mouth/teeth dental problems	1.3	2.0	3.5	-0.9	-1.9	-1.3
Pulse wave peak to peak time	1.3	1.5	2.3	-1.5	-0.9	-1.2
Medication for pain relief, constipation, heartburn	1.3	2.3	3.3	-1.8	-0.9	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	2.8	1.4	1.3	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	2.0	1.4	0.9	1.4
Pain type(s) experienced in last month: Hip pain	1.3	1.7	2.3	1.4	0.9	1.5
Fractured/broken bones in last 5 years	1.3	1.7	1.8	1.3	1.3	1.3
Ovarian Cancer	1.2	1.6	2.3	-1.2	-1.5	-1.1
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	1.7	1.3	0.9	1.3
Medication: Ramipril	1.2	1.5	2.4	0.8	1.5	1.2
Impedance of arm (right)	1.2	5.6	7.4	-2.7	-1.6	-2.7
Father’s age at death	1.2	1.7	2.7	1.6	-0.1	1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.5	2.4	1.0	1.5	1.1
Medication: Allopurinol	1.2	1.6	2.8	1.1	1.7	0.8
Impedance of whole body	1.2	6.2	7.8	-2.8	-1.8	-2.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.2	1.2	0.8	1.5
Relative age voice broke	1.1	1.7	2.0	-1.2	-1.4	-1.3
Nervous feelings	1.1	2.0	3.1	-1.3	-1.8	-1.1
Had other major operations	1.1	1.4	2.7	0.6	1.6	1.1
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.0	1.3	1.3	1.4
Leg fat mass (right)	1.1	4.3	4.7	2.2	1.9	2.1
Loneliness, isolation	1.1	1.6	2.8	-1.1	-1.7	-0.8
Ever depressed for a whole week	1.1	1.4	1.7	-1.3	-0.9	-1.3
Leg fat mass (left)	1.1	4.4	4.8	2.2	1.9	2.2
Multivitamins +/- minerals	1.0	1.3	3.2	-0.6	-1.8	-0.6
Alcohol intake versus 10 years previously	1.0	1.4	3.5	0.5	1.9	0.7
Wears glasses or contact lenses	1.0	1.2	1.7	1.0	1.3	0.9
Mother’s age at death	1.0	1.2	2.8	0.7	1.7	0.6
Risk taking	1.0	1.4	2.1	1.0	1.5	1.1
Hand grip strength (left)	0.9	2.4	2.7	1.6	1.3	1.6
Impedance of leg (left)	0.9	4.5	5.7	-2.4	-1.5	-2.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.0	1.3	0.7	1.4
Allergy	0.9	2.2	2.8	-1.7	-1.2	-1.5
Diabetes (self-reported)	0.9	1.4	2.0	0.8	1.4	1.2
Body fat percentage	0.9	3.5	3.6	1.9	1.9	1.9
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.5	1.2	0.2	1.2
Eye problems/disorders: Cataract	0.9	1.0	1.5	0.9	1.2	0.9
Alzheimer’s Disease (in mother)	0.8	1.0	1.5	-1.1	-0.5	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	1.4	-1.2	-0.7	-1.1
Cardiovascular Disease	0.8	2.8	3.2	1.5	1.7	1.8
Sitting height	0.8	5.7	6.2	-2.3	-2.5	-2.3
Hearing difficulty/problems with background noise	0.8	1.3	1.8	1.4	0.7	1.3
Birth weight of first child	0.8	1.5	1.8	1.3	1.3	1.0
Pulse wave reflection index	0.8	1.0	1.5	1.2	0.7	1.0
Medication: Amlodipine	0.8	1.1	1.6	-1.0	-1.2	-0.9
Birth weight	0.8	1.8	2.9	1.2	1.7	1.0
Qualifications: College or University degree	0.8	2.5	3.1	-1.5	-1.4	-1.8
Neck or shoulder pain in last month	0.8	1.1	1.8	1.3	0.2	1.2
Medication: Ibuprofen	0.8	1.0	1.6	-0.8	-1.3	-0.8
Guilty feelings	0.8	1.2	1.4	-1.1	-1.2	-1.0
Financial situation satisfaction	0.8	1.0	1.5	0.9	1.2	0.9
Ever smoked	0.8	1.3	2.3	-1.5	0.1	-1.3
Pack years of smoking	0.8	1.2	1.8	1.1	0.8	1.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.0	-1.0	-1.7	-1.1
Age at First Birth	0.7	1.0	2.8	-0.2	-1.7	-0.3
Chronotype (morning person)	0.7	1.6	2.6	-1.0	-1.6	-1.1
Trunk fat mass	0.7	2.9	3.2	1.8	1.5	1.8
Qualifications: None of the above	0.7	1.5	2.2	1.1	1.5	1.1
Weight	0.7	3.2	4.1	2.0	1.3	2.0
Medication: Cholesterol lowering	0.7	1.1	1.5	0.8	1.2	1.1
Depression (self-reported)	0.7	0.8	1.3	1.1	0.3	1.1
Arm fat mass (right)	0.7	2.9	3.3	1.8	1.5	1.8
Tense / ‘highly strung’	0.7	1.2	1.6	1.2	0.7	1.3
Worry too long after embarrassment	0.7	1.2	2.8	-0.7	-1.7	-0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.9	1.3	-1.1	-0.5	-1.0
Heart disease (mother)	0.7	0.8	1.3	-0.9	-0.6	-1.1
Whole body fat mass	0.7	3.0	3.3	1.8	1.6	1.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	2.3	-0.8	-1.5	-1.2
Commuting to job workplace: Walk	0.7	0.7	1.2	-1.1	-0.4	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.3	1.1	-0.3	1.0
Mean Putamen Volume	0.6	0.6	0.9	0.9	0.5	0.9
BMI	0.6	3.7	4.7	2.2	1.3	2.1
Diabetes (mother)	0.6	0.8	1.2	1.1	0.4	1.1
Trunk fat percentage	0.6	2.4	2.6	1.6	1.6	1.5
Neuroticism score	0.6	1.2	1.6	-1.1	-1.3	-0.9
Medication: Lansoprazole	0.6	0.6	0.9	0.9	0.5	0.9
Length of working week for main job	0.6	0.7	0.9	-0.9	-0.6	-0.8
Exposure to tobacco smoke at home	0.6	0.7	1.2	0.6	1.1	0.8
Health satisfaction	0.6	0.8	1.2	-1.1	-0.7	-0.8
Eye problems/disorders: None of the above	0.6	0.7	0.8	-0.9	-0.8	-0.9
Overall health rating	0.6	1.3	1.8	1.2	0.8	1.3
Arm fat mass (left)	0.6	2.6	2.9	1.7	1.4	1.7
Number of operations (self-reported)	0.6	0.9	2.5	0.2	1.6	0.4
Irritable Bowel Disease (IBD)	0.5	1.1	1.3	1.0	1.0	1.2
Coronary Artery Disease (CAD)	0.5	0.6	0.7	-0.7	-0.8	-0.8
Neuroticism (2016)	0.5	0.7	0.9	-0.7	-0.9	-0.8
Rheumatoid Arthritis	0.5	0.6	0.9	0.6	0.9	0.8
Smoking Status	0.5	1.2	1.9	-1.4	-0.4	-1.2
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.5	0.9	0.9	1.2
Sensitivity / hurt feelings	0.5	0.8	1.3	-0.8	-1.1	-0.8
Medication: Metformin	0.5	0.7	1.5	0.5	1.2	0.7
Pack years adult smoking proportion	0.5	0.8	1.2	0.8	0.8	1.1
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.8	0.9	-0.6	0.6
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.1	-0.9	-0.2	-1.0
Fluid intelligence score	0.5	1.1	1.5	-0.9	-1.2	-0.9
Arm fat percentage (right)	0.5	2.1	2.1	1.5	1.5	1.5
Comparative body size at age 10	0.5	1.5	2.2	1.5	0.6	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.4	-0.5	-1.2	-0.4
Angina (self-reported)	0.5	0.7	1.1	0.6	1.1	0.7
Family relationship satisfaction	0.5	0.7	1.2	-1.1	0.2	-0.9
Supplements: Vitamin C	0.5	0.6	0.8	0.6	0.9	0.7
Arm fat percentage (left)	0.5	2.2	2.3	1.5	1.4	1.5
Bipolar Disorder (2018)	0.4	0.7	1.1	1.0	0.1	1.0
Major Depression (MDD)	0.4	0.5	1.0	-0.5	-1.0	-0.5
Neuroticism	0.4	0.9	1.5	-0.9	-1.2	-0.7
Relative age of first facial hair	0.4	0.9	1.0	-1.0	-1.0	-0.8
Vitamin and mineral supplements	0.4	0.6	1.7	-0.2	1.3	-0.2
Supplements: Zinc	0.4	0.4	0.5	-0.6	-0.7	-0.6
Impedance of leg (right)	0.4	2.1	2.8	-1.7	-0.9	-1.6
Maternal smoking around birth	0.4	0.6	0.9	0.9	-0.3	0.9
Hip circumference	0.4	1.7	1.9	1.4	1.1	1.4
Qualifications: A levels/AS levels or equivalent	0.4	0.8	1.4	-1.0	-0.4	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.9	0.7	0.7	0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	0.8	-0.8	-0.7	-0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	1.5	-0.7	-1.2	-0.7
Number of children fathered	0.4	0.4	0.8	-0.9	-0.1	-0.7
Pulse rate, automated reading	0.4	1.5	1.8	-1.3	-1.0	-1.3
Ever taken oral contraceptive pill	0.4	0.4	0.4	-0.6	0.7	-0.6
Commuting to job workplace: Public transport	0.4	0.5	0.6	0.6	0.8	0.7
Medication: Paracetamol	0.4	0.6	0.8	0.9	0.5	0.9
Commuting to job workplace: Cycle	0.4	0.5	0.7	-0.8	-0.6	-0.7
Depressed Affect (Nagel 2018)	0.3	0.5	1.0	0.4	-1.0	0.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.1	-1.0	-0.6	-1.0
Crohns Disease (2017)	0.3	0.8	0.9	0.8	0.9	0.9
Breast Cancer	0.3	0.7	2.1	-0.2	-1.4	-0.3
Prostate Cancer	0.3	0.5	0.9	-0.5	-1.0	-0.5
Bipolar Disorder (2011)	0.3	0.3	0.5	0.3	0.7	0.5
Lupus	0.3	0.4	0.4	0.7	-0.7	0.6
Hypothyroidism (self reported)	0.3	0.6	1.6	-0.3	-1.3	-0.2
Angina	0.3	0.4	1.0	0.4	1.0	0.5
Medication for hormone replacement therapy	0.3	0.3	0.4	0.5	-0.6	0.6
Leg fat-free mass (left)	0.3	1.5	2.1	1.5	0.7	1.4
Average weekly fortified wine intake	0.3	0.4	0.6	-0.7	-0.2	-0.8
Age when periods started (menarche)	0.3	0.6	0.9	-0.9	-0.5	-0.9
Leg predicted mass (left)	0.3	1.7	2.3	1.5	0.7	1.4
Financial difficulties in last 2 years	0.3	0.5	0.8	0.7	-0.2	0.9
Heart attack	0.3	0.4	1.0	-0.4	1.0	-0.3
Time employed in main current job	0.3	0.4	0.6	0.6	-0.4	0.8
Pulse rate	0.3	0.5	0.6	-0.8	-0.7	-0.7
Noisy workplace	0.3	0.4	0.5	-0.7	-0.4	-0.7
Age at last live birth	0.3	0.4	0.5	0.7	0.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.5	-0.6	-0.4	-0.7
Back pain experienced in last month	0.3	0.5	0.8	0.7	0.5	0.9
Illnesses of father: None of the above (group 1)	0.3	0.4	0.8	0.9	0.3	0.6
Alcohol drinker status: Never	0.3	0.3	0.5	0.6	-0.1	0.7
Arm fat-free mass (left)	0.3	1.5	2.3	1.5	0.5	1.4
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.7	0.4	0.8	0.5
Supplements: Calcium	0.3	0.3	0.4	0.6	0.0	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.5	0.8	-0.4
Alzheimer’s Disease (in father)	0.2	0.2	0.6	0.2	0.8	0.3
Alzheimer’s Disease (including proxy)	0.2	0.3	0.5	0.5	0.7	0.4
Crohns Disease (2012)	0.2	0.3	0.9	0.1	-1.0	0.1
LDL Cholesterol	0.2	0.3	0.5	0.5	0.7	0.3
Blood Eosinophil Count	0.2	1.2	1.9	-0.7	-1.4	-1.1
Heel T-Score	0.2	1.2	2.4	-0.8	-1.5	-0.8
Allergy or Eczema	0.2	0.6	1.1	1.0	0.3	0.7
Lung FVC	0.2	0.9	1.0	-0.9	-1.0	-1.0
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.2	0.4	0.5	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.4	0.7	-0.3	0.5
Hand grip strength (right)	0.2	0.6	0.7	0.7	0.8	0.7
Medication: Atenolol	0.2	0.3	0.3	0.5	0.6	0.5
Number of incorrect matches in round	0.2	0.4	0.7	0.9	-0.2	0.6
Past tobacco smoking	0.2	0.4	0.6	0.7	-0.8	0.5
Worrier / anxious feelings	0.2	0.4	0.8	-0.5	-0.9	-0.5
Hair/balding pattern: Pattern 3	0.2	0.4	0.5	-0.6	-0.3	-0.7
Number of live births	0.2	0.3	0.5	-0.6	-0.4	-0.7
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	-0.3	-0.8	-0.3
Standing height	0.2	2.3	3.1	-1.3	-1.8	-1.4
Hair/balding pattern: Pattern 4	0.2	0.5	0.9	-0.6	-1.0	-0.4
Gout (self-reported)	0.2	0.3	0.5	0.7	0.4	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.5	0.3	0.6
Arm fat-free mass (right)	0.2	0.9	1.4	1.2	0.1	1.1
Emphysema/chronic bronchitis	0.2	0.2	0.5	0.2	0.7	0.3
Medication: Omeprazole	0.2	0.2	0.4	0.6	-0.0	0.5
Arm predicted mass (right)	0.2	0.9	1.5	1.2	0.2	1.1
Comparative height size at age 10	0.2	1.1	1.8	1.3	-0.4	1.1
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	-0.5	0.2	-0.7
Leg fat-free mass (right)	0.2	1.0	1.5	1.2	0.5	1.2
Mood swings	0.2	0.3	0.6	0.6	-0.2	0.8
Friendships satisfaction	0.2	0.3	0.5	-0.7	0.1	-0.5
Leg predicted mass (right)	0.2	1.0	1.5	1.2	0.4	1.2
Basal metabolic rate	0.2	1.2	1.8	1.3	0.4	1.2
Irritability	0.2	0.4	0.8	-0.9	-0.2	-0.6
Myopia	0.2	0.3	0.4	0.6	0.6	0.6
Heart disease (siblings)	0.2	0.2	0.3	0.5	0.6	0.3
Alcohol drinker status: Previous	0.2	0.2	0.4	0.6	0.0	0.5
Arm predicted mass (left)	0.2	0.9	1.4	1.2	0.1	1.1
Depression (Nagel 2018)	0.1	0.2	0.4	0.4	-0.2	0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.5	0.2	-0.7	0.3
Ulcerative Colitis (UC)	0.1	0.1	0.2	0.2	0.4	0.3
Fasting Glucose	0.1	0.1	0.2	-0.2	0.1	-0.4
HbA1C	0.1	0.1	0.2	0.1	-0.5	0.1
HDL Cholesterol	0.1	0.1	0.3	-0.2	-0.6	-0.0
Triglycerides	0.1	0.2	0.3	0.3	0.5	0.6
Ulcerative Colitis	0.1	0.1	0.4	0.0	-0.6	-0.1
Blood White Count	0.1	0.6	0.8	-0.8	-0.7	-0.9
Waist Hip Ratio (WHR)	0.1	0.3	0.5	0.7	0.3	0.5
Hair Pigment	0.1	1.8	2.1	-1.4	-1.1	-1.5
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.3	-0.3	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	-0.4	0.4	-0.1
Townsend deprivation index at recruitment	0.1	0.2	0.5	-0.0	0.7	0.2
Current tobacco smoking	0.1	0.1	0.2	-0.5	-0.1	-0.3
Fed-up feelings	0.1	0.2	0.3	0.4	-0.4	0.6
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.3	-0.1	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.3	-0.2	-0.5	0.0
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	-0.4	-0.1
High blood pressure (mother)	0.1	0.1	0.2	0.1	0.5	0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	0.3	0.4	0.3
Pain all over the body in last month	0.1	0.1	0.2	0.5	0.3	0.3
Trunk fat-free mass	0.1	0.4	0.6	0.8	-0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.1	-0.4	0.2	-0.1
Trunk predicted mass	0.1	0.4	0.5	0.7	-0.3	0.7
Loud music exposure frequency	0.1	0.1	0.3	0.2	0.6	0.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.2	0.5	0.4	0.5
Medication: Paracetamol	0.1	0.2	0.3	0.5	-0.6	0.4
Headache pain in last month	0.1	0.1	0.2	-0.2	-0.4	-0.3
Number of full brothers	0.1	0.1	0.2	-0.1	0.5	0.0
Migraine (self-reported)	0.1	0.1	0.2	-0.1	-0.2	-0.4
Mean time to correctly identify matches	0.1	0.1	0.3	-0.2	-0.5	-0.2
Had major operations	0.1	0.1	0.3	-0.0	0.6	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.3	0.3	0.4
Knee pain experienced in last month	0.1	0.2	0.3	0.6	0.2	0.5
Smoking status: Previous	0.1	0.1	0.3	-0.2	0.5	-0.1
Whole body fat-free mass	0.1	0.8	1.2	1.1	0.2	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	-0.2	0.4	0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.2	0.6	-0.2
Medication: Gliclazide	0.1	0.1	0.2	-0.5	-0.0	-0.3
Smoking status: Current	0.1	0.2	0.3	-0.6	-0.1	-0.4
Whole body water mass	0.1	0.6	1.0	1.0	0.0	0.9
Miserableness	0.1	0.2	0.3	-0.4	-0.6	-0.2
Hearing aid user	0.1	0.2	0.4	-0.2	-0.6	-0.2
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.2	-0.6	-0.1
Pain experienced in last month	0.1	0.2	0.6	0.0	0.8	-0.0
Basal cell carcinoma (self-reported)	0.1	0.1	0.2	-0.4	-0.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.2	0.4	0.4	0.4
Worry (Nagel 2018)	0.0	0.1	0.1	0.1	-0.4	0.0
Blood Platelet Count	0.0	0.1	0.1	0.4	-0.4	0.1
Blood Red Count	0.0	0.3	0.5	0.4	0.7	0.3
Height	0.0	0.6	1.7	0.0	-1.3	-0.2
Tanning	0.0	0.1	0.2	0.4	0.3	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.1	0.1	0.1	-0.4	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.0	-0.1	-0.0	-0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.1	0.1	-0.3	0.2
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.1	0.3	-0.1	-0.1
Medication: Levothyroxine sodium	0.0	0.0	0.0	-0.0	0.0	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	0.2	0.3	0.1
Illnesses of mother	0.0	0.0	0.0	0.1	-0.0	0.1
Blood clot in the leg (DVT)	0.0	0.0	0.1	0.1	0.3	0.1
Age at first live birth	0.0	0.0	0.0	0.2	0.0	0.1
Alcohol intake frequency.	0.0	0.1	0.2	0.2	0.2	0.4
Suffer from ‘nerves’	0.0	0.0	0.0	0.2	-0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.1	-0.3	-0.1	-0.3
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.1	-0.5	0.0

Hub : Genes

RNF38

Models

Trait associations