TWAS hub - RNF6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2800	0.0980	7.3e-03	-0.005	NA	-0.007	NA	0.009	4.8e-01	NA	5.9e-01	NA	1.7e-01
2	GTEx	Testis	0.3150	0.0730	1.6e-06	0.077	NA	0.047	NA	0.049	2.7e-04	NA	3.8e-03	NA	3.2e-03
3	TCGA	Breast Invasive Carcinoma	0.0234	0.0114	1.5e-03	0.011	0.013	0.011	NA	0.013	1.9e-03	8.0e-04	1.9e-03	NA	9.7e-04
4	TCGA	Brain Lower Grade Glioma	0.0553	0.0205	5.5e-06	0.067	0.039	0.048	NA	0.059	4.4e-08	2.5e-05	3.6e-06	NA	2.8e-07
5	TCGA	Prostate Adenocarcinoma	0.0504	0.0256	4.2e-03	0.014	0.014	0.030	NA	0.025	1.1e-02	1.2e-02	3.8e-04	NA	1.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Fasting Glucose	4.3	5.2	8.8	1.4	3.0	2.8	1.4	2.3
Reaction Time	3.8	7.2	10.7	3.3	2.9	2.8	3.0	0.5
Medication for hormone replacement therapy	3.4	3.9	6.5	-0.6	-2.0	-2.6	-2.2	1.9
Mean time to correctly identify matches	3.0	5.6	12.3	3.5	2.8	1.6	2.3	0.1
Medication: Bendroflumethiazide	3.0	4.5	9.5	2.0	3.1	2.3	1.9	0.1
Medication: Omeprazole (e.g. Zanprol)	2.7	3.3	6.0	-2.5	-1.0	-1.2	-2.3	-1.7
Mouth/teeth dental problems: Loose teeth	2.6	3.1	6.6	1.0	0.9	1.6	2.6	2.2
Alcohol drinker status: Never	2.6	3.1	6.7	1.7	0.7	2.1	2.6	1.0
Impedance of leg (right)	2.5	12.2	27.0	-5.2	-3.7	-2.9	-3.3	-1.1
Impedance of leg (left)	2.4	11.9	26.2	-5.1	-3.6	-3.0	-3.3	-0.7
Medication: Omeprazole	2.4	2.9	5.3	-2.3	-1.0	-1.1	-2.1	-1.5
Age at last live birth	2.4	3.4	7.9	-1.6	-0.5	-1.7	-2.8	-1.9
Financial situation satisfaction	2.4	3.0	6.2	1.1	2.5	2.1	1.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	3.9	1.9	1.1	1.3	1.9	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	5.6	-1.6	-1.1	-1.8	-2.4	-0.8
Ever used hormone-replacement therapy (HRT)	2.2	2.8	3.9	-1.5	-1.6	-1.9	-1.2	2.0
Vitamin and mineral supplements	2.2	2.9	11.9	3.5	1.0	-0.5	1.1	-0.4
Happiness	2.2	2.6	5.3	0.7	1.5	2.3	2.2	-0.3
Gout (self-reported)	2.2	3.0	6.3	1.4	1.6	2.5	2.0	0.5
Pain experienced in last month	2.2	3.7	8.4	-2.9	-1.3	-0.5	-1.3	-2.6
Serious illness, injury or assault to yourself	2.1	2.5	7.1	0.6	1.2	2.7	1.8	-0.8
Birth weight of first child	2.1	3.8	5.8	-2.3	-2.0	-1.5	-2.4	-1.1
Blood clot in the leg (DVT)	2.1	2.8	5.4	-0.1	2.2	1.8	-0.0	-2.3
Comparative body size at age 10	2.1	5.8	9.1	1.6	1.8	3.0	2.8	2.5
Age at first live birth	2.1	3.7	7.6	-1.8	-1.1	-1.9	-2.8	-1.7
Tinnitus: Yes, now most or all of the time	2.1	2.5	6.5	0.4	-2.2	-2.5	-0.6	-0.8
Depression (Nagel 2018)	2.0	3.0	8.3	1.0	-0.7	1.4	1.8	2.9
Ever had hysterectomy (womb removed)	2.0	2.2	3.6	-1.7	-1.9	-1.3	-1.4	-0.9
Alcohol intake versus 10 years previously	2.0	2.9	7.1	1.1	0.3	1.4	2.1	2.7
Qualifications: O levels/GCSEs or equivalent	2.0	3.1	6.3	-2.5	-1.5	-1.4	-2.1	0.8
Wears glasses or contact lenses	2.0	2.3	5.7	2.4	1.1	1.3	1.7	-0.1
Impedance of whole body	1.9	9.8	21.4	-4.6	-3.1	-2.5	-3.2	-1.1
Body Mass Index (BMI) (2010)	1.8	2.4	4.0	1.7	2.0	1.4	1.1	1.5
Systolic blood pressure, automated reading	1.8	5.2	10.5	3.2	2.8	0.9	2.3	1.2
Supplements: Zinc	1.8	2.0	6.2	-1.0	1.2	2.5	1.1	0.5
Medication: Allopurinol	1.8	2.4	6.7	0.4	1.6	2.6	1.0	-1.3
Number of full sisters	1.8	2.2	6.5	1.1	0.3	1.1	1.5	2.5
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	5.1	0.1	2.0	1.7	-0.0	-2.3
Rheumatoid Arthritis	1.7	2.3	6.1	2.5	2.2	-0.1	0.4	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	6.0	0.8	-0.1	1.7	1.5	2.4
Qualifications: A levels/AS levels or equivalent	1.7	3.7	6.2	-2.5	-1.7	-1.8	-2.1	-1.4
Leg fat-free mass (right)	1.7	9.0	12.9	3.6	3.5	3.2	2.8	1.1
Handedness (chirality/laterality): Left-handed	1.7	2.0	4.4	2.1	-0.2	1.1	1.9	0.9
Guilty feelings	1.7	2.6	3.9	1.0	1.8	2.0	1.8	1.2
Coronary Artery Disease (CAD)	1.6	1.9	5.6	-0.8	0.5	1.2	1.3	2.4
BMI	1.6	9.3	13.0	3.6	3.2	3.1	3.4	1.4
Medication: Metformin	1.6	2.2	6.6	1.7	-0.7	0.4	1.1	2.6
Leg fat-free mass (left)	1.6	8.4	12.3	3.3	3.5	3.2	2.7	0.8
Leg predicted mass (left)	1.6	8.6	12.7	3.3	3.6	3.3	2.7	0.8
Arm fat mass (right)	1.6	6.5	10.7	2.3	3.3	3.0	2.5	1.1
Knee pain experienced in last month	1.6	2.5	8.5	2.9	1.3	0.1	1.3	0.8
Osteoporosis (self-reported)	1.6	1.9	4.3	0.5	-1.6	-2.1	-0.9	1.3
Leg predicted mass (right)	1.6	8.7	12.6	3.6	3.5	3.2	2.7	1.1
Arm fat mass (left)	1.6	6.7	12.2	2.3	3.5	3.1	2.5	0.8
Depressed Affect (Nagel 2018)	1.5	3.2	5.3	0.7	1.6	2.0	2.3	1.8
Multivitamins +/- minerals	1.5	1.9	6.4	-2.5	-0.5	1.4	-0.4	0.9
Body mass index (BMI)	1.5	6.3	10.2	2.5	3.2	2.8	2.6	1.0
Depression (self-reported)	1.5	1.8	4.1	-1.9	0.7	0.3	-0.7	-2.0
Exposure to tobacco smoke at home	1.5	1.7	3.0	1.6	0.0	1.1	1.7	1.4
Basal metabolic rate	1.5	8.4	11.8	3.3	3.4	3.1	2.8	1.2
Unable to work because of sickness or disability	1.5	1.9	4.4	-2.1	-0.8	-1.2	-1.8	0.1
Pack years of smoking	1.5	2.2	7.1	2.7	1.2	0.9	1.2	0.6
Primary Biliary Cirrhosis	1.4	2.0	9.5	-0.4	0.1	0.4	0.5	3.1
Diabetes (father)	1.4	1.8	2.6	1.5	-0.3	1.6	1.2	1.6
Current tobacco smoking	1.4	2.2	3.3	1.8	1.6	1.8	1.0	1.1
Average weekly fortified wine intake	1.4	1.6	5.0	0.1	-2.2	-1.0	-0.8	1.2
Number of incorrect matches in round	1.4	2.4	7.2	1.9	0.9	-0.1	0.5	2.7
Weight	1.4	6.7	11.7	2.4	3.4	3.1	2.4	0.9
Arm fat percentage (right)	1.4	5.4	9.7	1.8	3.1	2.9	2.3	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.2	4.0	-2.0	-1.2	-0.7	-1.9	-1.1
Loud music exposure frequency	1.4	1.6	3.0	-0.9	-0.9	-1.6	-1.7	-0.7
Shortness of breath walking on level ground	1.4	1.7	6.9	0.4	0.3	0.9	0.7	2.6
Whole body fat-free mass	1.4	8.2	12.0	3.5	3.2	3.0	2.8	1.3
Arm fat percentage (left)	1.4	5.8	10.9	1.6	3.3	3.2	2.3	0.5
Qualifications: nursing, teaching	1.4	2.1	8.1	-2.8	0.0	0.5	-1.3	-0.9
Whole body water mass	1.4	8.0	12.1	3.5	3.3	2.9	2.7	1.2
Type 2 Diabetes (T2D) (2012)	1.3	1.5	4.4	-0.4	-2.1	-1.6	-0.4	0.3
Eye problems/disorders: Diabetes related eye disease	1.3	1.4	3.6	1.1	-1.0	-1.0	-0.1	1.9
Trunk fat-free mass	1.3	7.6	12.3	3.5	3.0	2.8	2.8	1.2
Trunk predicted mass	1.3	7.4	12.0	3.5	3.0	2.7	2.7	1.1
Neck or shoulder pain in last month	1.3	1.8	2.3	1.5	1.4	1.2	1.5	1.1
Whole body fat mass	1.3	5.5	11.6	1.4	3.4	3.0	2.1	0.7
Had major operations	1.3	1.5	6.1	-0.7	-2.5	-0.7	-0.4	0.7
Mood swings	1.3	2.4	3.9	0.4	1.4	1.8	2.0	1.6
Osteoarthritis (self-reported)	1.3	1.6	5.8	2.4	0.7	-1.0	0.3	0.8
Leg fat mass (left)	1.3	5.0	10.0	1.5	3.2	2.8	2.2	0.7
Medication: Co-codamol	1.2	1.4	3.7	-0.3	-1.4	-1.1	-0.4	1.9
Relative age voice broke	1.2	1.8	4.9	-1.5	-2.2	-0.8	-1.0	-0.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.5	-0.7	-1.2	-1.9	-1.2	-0.4
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	3.2	1.5	-0.8	0.4	1.8	0.5
Qualifications: CSEs or equivalent	1.2	1.5	6.8	0.4	-0.7	0.1	0.5	2.6
Illnesses of siblings	1.2	1.7	3.0	0.5	0.1	1.6	1.7	1.7
Neuroticism score	1.2	2.6	4.0	0.9	1.3	2.0	1.7	1.9
Father’s age at death	1.2	1.6	4.9	0.5	1.3	2.2	0.9	-0.3
Impedance of arm (left)	1.2	5.8	12.5	-3.5	-2.5	-1.4	-2.6	-1.2
Leg fat mass (right)	1.2	4.6	8.9	1.4	3.0	2.7	2.1	0.6
Arm predicted mass (right)	1.2	6.1	9.8	2.7	3.1	2.5	2.4	1.2
Diabetes diagnosed by doctor	1.2	2.0	4.3	2.1	-1.2	-0.0	0.7	1.9
Arm fat-free mass (left)	1.2	5.9	9.6	2.8	3.1	2.1	2.4	1.3
Arm predicted mass (left)	1.2	6.1	9.8	3.0	3.1	2.1	2.4	1.3
Age at First Birth	1.1	1.6	2.6	-1.6	-0.7	-0.9	-1.5	-1.3
Neuroticism	1.1	2.8	4.3	1.2	1.2	1.9	2.1	1.7
Relative age of first facial hair	1.1	2.4	3.9	-1.5	-1.3	-2.0	-1.9	0.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.4	-0.6	-1.5	-1.5	-1.3	-0.0
Trunk fat mass	1.1	4.7	10.3	1.1	3.2	2.9	1.9	0.5
Waist circumference	1.1	4.0	5.2	2.0	2.3	2.2	2.2	1.0
Impedance of arm (right)	1.1	5.3	10.1	-3.2	-2.5	-1.7	-2.5	-1.1
Headache pain in last month	1.1	1.9	4.3	2.0	-0.6	-0.7	0.5	2.1
Number of children fathered	1.1	1.2	2.5	1.6	0.7	0.9	1.3	0.6
Medication for pain relief, constipation, heartburn	1.1	1.8	5.2	0.4	0.3	1.1	1.6	2.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	1.8	-0.8	-1.4	-1.4	-1.2	-1.0
Leg fat percentage (left)	1.1	4.0	9.5	0.6	3.1	2.5	2.0	0.4
Irritability	1.1	1.9	6.7	0.3	2.6	0.7	1.0	-1.0
Commuting to job workplace: Cycle	1.1	1.3	2.8	0.5	1.1	1.5	1.7	0.3
Schizophrenia (2018)	1.0	2.2	6.1	2.5	0.8	1.2	1.2	-1.2
Neuroticism (2016)	1.0	1.4	6.0	0.5	-0.3	-0.8	-0.0	2.5
Diabetes (self-reported)	1.0	1.5	2.7	1.5	-1.5	-0.4	0.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.5	4.2	0.3	-0.0	2.1	1.3	1.3
Leg fat percentage (right)	1.0	3.6	7.9	0.6	2.8	2.4	2.0	0.2
Wheeze or whistling in the chest in last year	1.0	1.8	4.6	1.1	1.1	0.9	1.1	2.2
Medication: Seretide 50 evohaler	1.0	1.1	3.7	0.9	0.3	-1.0	0.3	1.9
Smoking status: Current	1.0	1.5	2.7	1.6	1.4	1.4	0.6	0.8
Eye problems/disorders: Glaucoma	1.0	1.2	4.4	2.1	0.5	-0.1	1.1	0.0
Alzheimer’s Disease (in mother)	0.9	1.1	2.4	1.5	0.0	1.1	1.1	0.8
Type 2 Diabetes (T2D) (2018)	0.9	1.8	4.0	1.7	-1.2	0.1	0.4	2.0
Hearing difficulty/problems: Yes	0.9	1.3	2.3	1.5	0.1	1.4	1.5	-0.2
Pack years adult smoking proportion	0.9	1.4	5.4	2.3	0.9	0.4	0.6	0.5
Breastfed as a baby	0.9	1.1	4.7	0.0	-0.7	-0.1	0.3	2.2
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.9	1.7	0.6	0.1	1.3	0.8
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.2	-1.0	-1.3	-1.5	-0.7	-0.4
Arm fat-free mass (right)	0.9	4.8	8.1	2.5	2.8	2.3	2.0	0.9
Emphysema/chronic bronchitis	0.9	1.0	2.4	-0.1	0.8	1.5	0.8	1.2
Number of operations (self-reported)	0.9	1.3	2.2	-1.5	-1.0	-0.6	-1.1	-1.4
Supplements: Calcium	0.9	1.0	2.5	-1.6	-1.3	-0.6	-0.6	-0.1
Basal cell carcinoma (self-reported)	0.9	1.1	2.4	-0.0	1.1	0.3	1.4	1.5
Sensitivity / hurt feelings	0.8	1.3	3.6	-1.5	-0.9	0.0	0.1	1.9
Taking other prescription medications	0.8	1.2	2.6	-0.7	-0.7	-1.5	-1.6	-0.0
Medication: Atenolol	0.8	1.0	2.5	0.3	1.6	1.3	0.8	0.3
Financial difficulties in last 2 years	0.8	1.0	1.9	0.5	1.4	0.9	1.1	1.0
Medication: Ramipril	0.8	1.0	2.4	0.1	-0.7	-1.6	-1.1	-0.9
Number of live births	0.8	1.1	2.1	-0.3	-1.2	-1.4	-1.4	0.1
Medication: Lansoprazole	0.8	1.0	3.6	0.8	-0.1	-0.5	-0.5	1.9
Ever highly irritable/argumentative for 2 days	0.8	0.9	1.6	-1.2	0.9	0.2	-0.9	-1.2
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.2	1.5	0.3	-0.0	0.8	1.4
Medication: Paracetamol	0.8	1.3	3.0	1.7	1.2	-0.8	0.4	1.1
Body fat percentage	0.8	3.2	8.1	0.2	2.9	2.4	1.4	0.4
Long-standing illness, disability or infirmity	0.8	1.2	2.6	0.8	0.4	1.5	1.6	0.8
Back pain experienced in last month	0.8	1.1	4.6	0.5	0.6	0.3	0.5	2.2
Medication: Paracetamol	0.8	1.3	3.5	1.1	1.2	-0.1	0.6	1.9
Bipolar Disorder or Schizophrenia	0.7	1.6	5.3	2.3	-0.0	0.5	0.5	-1.5
Alzheimer’s Disease (in father)	0.7	0.7	1.3	-1.1	1.0	1.1	0.1	-0.2
Alzheimer’s Disease (including proxy)	0.7	1.1	3.3	0.4	1.1	1.8	0.8	0.2
Severe depression (siblings)	0.7	0.7	1.5	-1.2	-1.2	-0.1	-0.4	0.8
Fed-up feelings	0.7	1.2	2.1	0.2	1.4	1.1	1.0	1.3
Medication: Levothyroxine sodium	0.7	1.1	2.4	1.2	-0.7	-1.0	-0.6	-1.5
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.6	0.6	0.8	1.6	1.0	-0.2
Pain all over the body in last month	0.7	0.7	1.4	0.1	0.7	1.2	1.1	0.7
Hip circumference	0.7	3.1	7.0	1.2	2.7	2.1	1.6	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	1.4	0.3	-0.7	1.2	0.4
Medication: Cholesterol lowering	0.7	1.1	2.7	1.6	0.5	1.0	1.3	0.1
Heart disease (mother)	0.7	0.9	1.7	1.3	1.2	0.4	1.0	0.1
Alcohol intake frequency.	0.7	1.5	2.8	1.1	0.6	1.7	1.6	0.6
Comparative height size at age 10	0.7	4.0	7.1	2.7	1.4	1.4	2.0	2.3
Overall health rating	0.7	1.5	2.5	1.6	0.8	1.4	1.5	0.1
Leg pain on walking	0.7	0.9	1.7	0.9	-0.1	1.1	0.9	1.3
Average weekly red wine intake	0.7	1.0	3.6	-0.7	1.0	-0.2	-0.0	-1.9
Medication: Atorvastatin	0.7	0.8	1.8	1.3	-0.8	-0.0	0.6	1.2
Cholesterol lowering medication	0.7	1.0	2.7	0.4	-1.6	-0.5	0.2	1.4
Triglycerides	0.6	0.9	2.8	0.1	1.2	0.7	0.2	1.7
Number of treatments/medications taken	0.6	1.1	2.3	-0.9	-0.4	-1.5	-1.5	-0.4
Diabetes (mother)	0.6	0.8	1.7	0.3	-1.3	-1.2	-0.8	0.0
Trunk fat percentage	0.6	2.3	6.0	-0.2	2.4	2.1	1.0	0.2
Hand grip strength (right)	0.6	1.6	2.6	-0.3	-1.3	-1.5	-1.6	-1.3
Age when periods started (menarche)	0.6	1.5	3.0	0.1	1.7	1.6	1.3	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.2	2.4	1.5	-0.4	-1.2	-0.2	-1.5
Hair/balding pattern: Pattern 2	0.6	0.8	2.0	1.4	0.9	0.6	0.6	-0.5
Time employed in main current job	0.6	0.6	2.0	1.4	0.8	0.3	0.5	-0.5
Noisy workplace	0.6	0.7	1.9	0.7	-0.8	-1.4	-0.5	0.4
Lung cancer (father)	0.6	0.7	2.5	1.6	0.4	-0.0	0.7	0.6
Pulse wave Arterial Stiffness index	0.6	0.7	1.4	1.2	0.6	0.8	1.0	-0.6
Pulse wave reflection index	0.6	0.7	1.0	0.9	-0.3	0.9	0.9	-1.0
Pulse wave peak to peak time	0.6	0.7	1.1	-1.0	-0.5	-0.8	-1.0	0.7
Supplements: Vitamin C	0.6	0.8	1.7	-0.9	0.8	1.3	0.4	0.7
Hypertension (Self-reported)	0.6	1.7	3.2	1.8	1.3	0.3	1.3	1.3
Commuting to job workplace: Walk	0.6	0.7	2.2	-0.1	-0.2	1.5	0.6	0.8
Eye problems/disorders: Cataract	0.6	0.7	2.2	-0.9	1.5	0.5	-0.2	-0.6
Medication: Gliclazide	0.6	0.6	1.6	0.6	-0.9	-0.5	0.2	1.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.1	-0.7	0.8	1.1	0.8	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	2.9	-0.6	-0.7	-0.3	-0.5	-1.7
Diastolic blood pressure, automated reading	0.6	1.9	5.0	1.6	2.2	0.8	1.1	0.1
Bipolar Disorder (2011)	0.5	0.5	1.8	0.9	-1.3	-0.3	-0.1	0.0
Crohns Disease (2012)	0.5	0.8	3.1	1.8	0.3	0.0	0.3	0.9
HDL Cholesterol	0.5	0.9	4.2	-0.4	0.0	-0.3	-0.2	-2.1
Lupus	0.5	0.7	3.2	0.0	0.1	-0.2	0.6	1.8
Smoking Status	0.5	1.2	4.8	0.8	2.2	0.5	-0.3	-0.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	-0.0	-0.1	1.5	0.7	1.0
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.6	-1.9	-0.8	-0.2	-0.8	0.6
Supplements: Glucosamine	0.5	0.7	2.3	-0.3	1.5	0.9	0.5	0.1
Alcohol usually taken with meals	0.5	0.7	1.3	-1.2	-0.2	-0.9	-1.2	-0.2
Nervous feelings	0.5	1.0	1.7	0.5	0.3	1.3	1.2	1.2
Fluid intelligence score	0.5	1.0	3.5	-1.9	-0.9	0.6	-0.7	-0.1
Asthma	0.5	0.9	1.9	-0.5	-1.1	-1.4	-0.9	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.8	0.3	1.1	1.4	0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.0	-0.8	-1.0	-0.9	-0.3	-0.4
Illnesses of father: Heart disease	0.5	0.8	1.4	0.0	-1.2	-1.1	-0.3	1.0
Illnesses of siblings: Diabetes	0.5	0.6	1.3	0.6	-0.6	-1.1	-0.9	0.4
Medication for cholesterol	0.5	0.8	1.9	-0.1	0.8	1.1	0.4	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.0	0.1	1.0	0.1	0.1	1.4
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.8	-1.1	-0.3	-0.9	0.9
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.7	-1.3	-0.5	-0.6	-1.0	-0.1
High cholesterol (Self-reported)	0.5	0.9	2.2	1.1	0.4	0.3	1.5	0.8
Illnesses of father: High blood pressure	0.5	0.6	2.4	0.5	-1.6	-0.4	0.3	0.1
Risk taking	0.5	0.7	1.3	-1.1	0.9	0.3	-1.0	-0.6
Bipolar Disorder (2018)	0.4	0.6	1.0	0.6	-1.0	-0.7	-0.7	-0.9
Neuroticism (Nagel 2018)	0.4	0.9	1.8	0.3	0.7	0.8	1.2	1.4
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	-0.9	-0.8	-0.6	-0.9	-0.1
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.2	-1.5	-1.0	1.1	-0.1	0.0
Breast Cancer	0.4	1.0	3.4	-1.8	-0.3	-0.6	0.0	-1.1
Ovarian Cancer	0.4	0.5	1.7	-1.3	0.5	0.3	0.2	-0.6
Mean Putamen Volume	0.4	0.5	1.5	0.6	0.1	0.6	1.2	0.6
HbA1C	0.4	0.4	0.6	0.7	-0.4	-0.5	0.8	0.6
Schizophrenia (2014)	0.4	1.0	2.0	1.4	-0.0	0.9	0.6	-1.3
Cardiovascular Disease	0.4	1.2	3.5	1.9	0.3	-0.7	1.2	0.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.8	0.4	-1.3	0.2	0.8	0.5
High blood pressure	0.4	1.1	2.4	1.6	0.9	-0.0	1.0	1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	-0.9	0.7	-0.1	0.0	-1.2
Mouth/teeth dental problems	0.4	0.6	2.3	-0.1	-0.1	-0.6	-0.6	-1.5
Heart attack	0.4	0.5	1.5	0.3	-1.2	-0.6	-0.5	0.3
Falls in the last year	0.4	0.5	0.9	0.7	-0.9	0.8	-0.0	0.7
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.2	0.6	0.2	-0.2	0.1	-1.5
Peak expiratory flow (PEF)	0.4	0.9	2.0	-0.8	-1.3	-1.4	-0.1	0.0
Glaucoma (self-reported)	0.4	0.4	1.0	1.0	0.2	0.2	0.6	0.8
Worry too long after embarrassment	0.4	0.6	1.8	-0.9	-1.3	-0.2	-0.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	0.6	0.4	1.2	0.7	-0.2
Medication: Ibuprofen	0.4	0.5	2.2	0.3	0.4	-0.2	0.1	-1.5
Loneliness, isolation	0.4	0.5	1.7	-0.3	-0.0	1.3	0.9	0.1
Ever had bowel cancer screening	0.4	0.4	0.9	-0.5	0.9	1.0	0.4	-0.0
Illnesses of father: None of the above (group 1)	0.4	0.4	0.9	0.1	1.0	0.6	0.8	0.6
Hearing aid user	0.4	0.4	0.9	0.0	0.9	-1.0	-0.4	-0.5
Mother’s age at death	0.4	0.5	0.9	0.6	0.7	0.7	1.0	0.5
Commuting to job workplace: Public transport	0.4	0.5	1.1	-0.9	-1.1	-0.4	-0.4	-0.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.5	-0.7	1.2	0.6	0.3	0.3
Prostate Cancer	0.3	0.4	0.8	0.4	0.6	0.6	0.9	-0.7
LDL Cholesterol	0.3	0.5	1.3	-0.8	0.7	-0.5	-1.2	-0.1
Blood White Count	0.3	1.9	3.9	1.4	0.9	1.6	2.0	0.5
Chronotype (morning person)	0.3	0.7	1.8	1.1	-0.0	0.3	1.4	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.6	-0.1	1.3	0.6	0.1	0.2
Hearing difficulty/problems with background noise	0.3	0.5	0.9	-0.2	-0.2	0.9	0.6	-1.0
Had other major operations	0.3	0.4	1.0	-0.8	1.0	-0.5	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.8	1.3	-0.4	-0.3	0.3	-0.9
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	-1.1	0.6	0.2	-0.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.2	-0.5	-0.3	-1.5	-0.8	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.8	1.7	0.4	-0.0	0.5	-0.0
Exposure to tobacco smoke outside home	0.3	0.4	0.8	-0.8	-0.6	0.6	-0.2	0.9
Number of full brothers	0.3	0.3	0.7	-0.0	0.8	0.8	0.3	0.5
Qualifications: College or University degree	0.3	1.1	2.7	-1.6	-1.0	0.2	-0.6	-1.1
Medication: Blood pressure	0.3	0.5	1.3	1.1	1.1	0.2	-0.1	-0.2
Smoking status: Previous	0.3	0.4	0.8	-0.9	0.6	-0.4	-0.6	-0.2
Friendships satisfaction	0.3	0.3	1.2	0.3	-0.1	0.5	1.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.0	-0.9	0.6	1.0	0.3	-0.3
Mineral and other dietary supplements	0.3	0.5	1.2	1.1	-1.0	-0.3	0.0	0.4
Breast cancer (self-reported)	0.3	0.4	0.9	-1.0	-0.5	-0.3	-0.6	-0.5
Asthma (self-reported)	0.3	0.6	1.5	-0.4	-0.8	-1.2	-0.8	0.5
Medication: Aspirin	0.3	0.4	1.4	0.4	-0.3	0.4	-0.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.9	0.5	0.2	-0.7	0.6	1.4
Miserableness	0.3	0.5	0.9	-0.6	0.3	0.8	0.6	1.0
Ever taken oral contraceptive pill	0.3	0.4	0.9	0.6	0.9	0.8	0.3	-0.1
Medication: Lisinopril	0.3	0.4	0.8	0.3	0.6	-0.9	-0.6	0.5
Age started oral contraceptive pill	0.3	0.4	1.7	-0.0	-1.3	-0.5	-0.5	0.2
Myopia	0.3	0.4	1.1	-0.6	0.6	1.0	0.0	-0.3
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.3	-1.5	-0.7	0.4	-0.8	-1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.4	0.2	-1.2	-0.5	-0.6	0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.8	-0.9	-0.8	0.7	0.1	-0.9
Ulcerative Colitis	0.2	0.4	0.6	0.7	0.8	0.6	0.3	0.5
Blood Platelet Count	0.2	2.1	3.8	-1.9	-0.7	-1.9	-1.3	-1.0
Systolic Blood Pressure	0.2	1.0	2.0	1.4	1.0	-0.5	0.9	1.1
Allergy or Eczema	0.2	0.6	2.8	-1.7	0.4	-0.0	-0.4	0.3
Respiratory disease	0.2	0.4	1.2	0.3	0.8	-0.1	0.4	1.1
Lung FVC	0.2	1.2	2.3	-0.9	-0.2	-1.4	-1.0	-1.5
Tanning	0.2	2.1	6.4	1.8	2.5	0.3	0.9	0.4
Maternal smoking around birth	0.2	0.3	0.5	0.7	0.5	-0.7	-0.4	-0.2
Stomach or abdominal pain in last month	0.2	0.3	1.0	0.6	1.0	-0.2	-0.1	0.3
Had menopause	0.2	0.2	0.9	-0.2	0.2	-0.4	-1.0	-0.3
Allergy	0.2	0.6	2.2	1.5	-0.3	-0.5	0.4	-0.3
Medication: Simvastatin	0.2	0.3	0.5	0.7	0.3	0.3	0.6	0.5
Prospective memory result	0.2	0.2	0.6	-0.5	0.3	-0.2	-0.4	-0.8
Hair/balding pattern: Pattern 4	0.2	0.6	2.0	0.4	0.3	0.7	0.4	1.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-1.0	-0.4	-0.0	-0.2	0.7
Medication: Amlodipine	0.2	0.2	0.9	1.0	0.2	0.1	0.3	0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	2.0	-0.4	-0.3	-1.4	-0.6	-0.8
Migraine (self-reported)	0.2	0.3	0.5	0.5	-0.7	-0.0	-0.1	-0.7
Chest pain or discomfort	0.2	0.3	1.1	-1.0	-0.5	0.4	-0.2	0.5
Family relationship satisfaction	0.2	0.3	0.8	-0.6	0.3	-0.0	-0.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.9	0.0	0.9	0.1	0.2	0.5
Medication: Aspirin	0.2	0.2	0.7	0.4	-0.4	0.2	-0.0	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.6	-0.1	0.2	-0.4	-0.8	-0.4
Number of self-reported non-cancer illnesses	0.2	0.4	1.4	1.2	0.4	-0.6	0.0	0.5
Medication: Blood pressure	0.2	0.5	0.9	0.6	0.9	0.3	0.6	0.8
Heart disease (siblings)	0.2	0.3	0.6	-0.1	0.3	-0.7	-0.4	-0.8
Worry (Nagel 2018)	0.1	0.3	1.2	0.5	-0.2	-0.2	0.1	1.1
Crohns Disease (2017)	0.1	0.2	0.3	0.1	0.2	-0.4	-0.5	0.6
Irritable Bowel Disease (IBD)	0.1	0.2	0.4	0.0	0.5	-0.1	-0.3	0.7
Ulcerative Colitis (UC)	0.1	0.3	0.6	0.3	0.8	0.3	0.3	0.6
Major Depression (MDD)	0.1	0.1	0.3	0.2	-0.4	-0.6	-0.0	0.1
Blood Red Count	0.1	1.2	3.5	-0.8	0.6	1.9	1.0	0.5
Heel T-Score	0.1	1.0	2.6	1.6	-0.0	0.5	1.5	0.1
Waist Hip Ratio (WHR)	0.1	0.5	0.9	0.4	-0.6	0.6	0.9	0.9
Hypothyroidism (self reported)	0.1	0.3	1.2	0.5	-0.2	-0.4	-0.2	-1.1
Lung FEV1/FVC ratio	0.1	0.8	2.3	-0.0	1.0	0.5	0.5	1.5
Hair Pigment	0.1	2.0	3.4	-1.7	1.2	1.8	0.9	-1.3
Hand grip strength (left)	0.1	0.2	0.3	0.1	-0.4	-0.5	-0.4	-0.6
Average weekly spirits intake	0.1	0.2	0.3	-0.1	0.6	-0.4	0.6	0.4
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.3	-0.2	0.2	0.3	-0.3
Sitting height	0.1	0.8	2.2	0.6	1.5	0.4	-0.2	-1.1
High blood pressure (mother)	0.1	0.2	0.5	-0.6	-0.2	-0.1	-0.2	-0.7
Past tobacco smoking	0.1	0.3	0.5	0.3	-0.7	0.5	0.7	0.1
Forced vital capacity (FVC)	0.1	0.5	1.0	1.0	0.4	-1.0	0.4	0.0
Qualifications: None of the above	0.1	0.2	0.6	0.4	0.7	-0.2	0.5	-0.3
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.6	-0.1	-0.2	-0.8	0.1	0.5
Worrier / anxious feelings	0.1	0.2	0.4	-0.7	0.3	0.6	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.6	0.6	-0.0	-1.3	0.1	0.1
Pulse rate	0.1	0.1	0.4	-0.6	0.3	0.0	-0.3	0.2
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.1	-0.3	-0.1	-0.6	0.7
Length of working week for main job	0.1	0.1	0.2	0.3	-0.2	0.2	-0.1	-0.4
Tense / ‘highly strung’	0.1	0.2	0.4	0.2	0.1	-0.5	-0.7	-0.5
High blood pressure (siblings)	0.1	0.2	0.5	-0.0	-0.1	-0.4	-0.7	-0.5
Health satisfaction	0.1	0.2	0.5	0.2	-0.5	0.4	-0.1	-0.7
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.4	-0.3	0.0	0.0	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.2	0.7	0.2	0.2	0.3	0.0	0.9
Ever smoked	0.1	0.2	0.5	0.0	0.5	-0.2	-0.7	-0.2
Average weekly beer plus cider intake	0.1	0.1	0.2	0.4	-0.1	-0.3	-0.3	-0.0
Ever depressed for a whole week	0.1	0.1	0.3	-0.2	0.0	-0.6	-0.0	-0.3
Alcohol drinker status: Previous	0.1	0.2	0.3	-0.2	0.2	0.0	-0.6	-0.6
Blood Eosinophil Count	0.0	0.3	0.9	1.0	-0.1	-0.2	0.4	-0.4
Height	0.0	0.7	2.2	1.5	0.8	0.1	0.2	0.6
Angina	0.0	0.0	0.1	-0.2	0.0	0.1	-0.3	-0.0
Illnesses of mother	0.0	0.0	0.1	0.0	0.1	-0.2	-0.0	-0.3
Standing height	0.0	0.3	0.5	0.6	0.7	0.7	0.1	0.2
Birth weight	0.0	0.1	0.2	0.2	-0.4	-0.3	-0.2	0.4
Angina (self-reported)	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2	-0.1
Pulse rate, automated reading	0.0	0.1	0.1	0.2	0.3	0.1	-0.3	-0.2
Suffer from ‘nerves’	0.0	0.0	0.1	0.2	0.1	0.0	-0.0	0.3

Hub : Genes

RNF6

Models

Trait associations