Hub : Genes

ROMO1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 ROSMAP Brain Pre-frontal Cortex 0.0599 0.0294 0.0024 0.023 0.006 0.011 0.011 0.010 5.3e-04 5.4e-02 1.2e-02 1.2e-02 1.7e-02
2 YFS Blood 0.1141 0.0261 0.0000 0.150 0.170 0.173 0.168 0.172 1.1e-46 3.7e-53 2.3e-54 1.4e-52 6.2e-54

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.8 2.8 3.6 1.9 -1.4
Bipolar Disorder or Schizophrenia 0.5 1.3 1.5 1.2 -1.1
Depressed Affect (Nagel 2018) 0.4 0.9 0.9 0.9 -0.9
Depression (Nagel 2018) 0.0 0.0 0.0 0.0 0.0
Intelligence (Savage-Jansen 2018) 0.8 2.4 3.6 -1.1 1.9
Neuroticism (Nagel 2018) 0.0 0.1 0.1 -0.0 0.4
Schizophrenia (2018) 0.0 0.1 0.1 -0.3 -0.2
Schizophrenia vs Biploar Disorder 0.2 0.2 0.4 -0.6 0.2
Worry (Nagel 2018) 0.2 0.4 0.7 -0.4 0.8
Alzheimer’s Disease (in mother) 0.0 0.0 0.1 -0.1 -0.2
Alzheimer’s Disease (in father) 2.2 2.4 2.8 1.4 -1.7
Alzheimer’s Disease (including proxy) 0.7 1.1 1.4 0.8 -1.2
Crohns Disease (2017) 0.6 1.4 1.4 -1.2 1.2
Irritable Bowel Disease (IBD) 0.6 1.5 1.7 -1.1 1.3
Ulcerative Colitis (UC) 0.3 0.6 0.7 -0.7 0.9
Major Depression (MDD) 1.4 1.6 2.1 1.1 -1.4
Reaction Time 5.1 9.8 11.7 2.8 -3.4
Verbal and Numeric Reasoning (VNR) 0.5 1.1 2.0 -0.4 1.4
Breast Cancer 0.2 0.5 1.0 -1.0 0.3
Ovarian Cancer 0.2 0.2 0.4 -0.2 -0.6
Prostate Cancer 0.0 0.1 0.1 -0.0 -0.4
Age at First Birth 3.2 4.7 4.7 -2.2 2.2
Bipolar Disorder (2011) 0.1 0.1 0.2 -0.0 0.4
Body Mass Index (BMI) (2010) 0.3 0.4 0.7 0.3 -0.8
Coronary Artery Disease (CAD) 0.5 0.7 1.1 0.4 -1.1
Crohns Disease (2012) 0.2 0.3 0.6 -0.3 0.8
Mean Putamen Volume 0.7 0.8 0.9 -0.9 0.9
Fasting Glucose 0.6 0.7 1.0 -0.6 1.0
HbA1C 1.0 1.1 1.5 1.2 -0.9
HDL Cholesterol 0.2 0.3 0.5 0.2 -0.7
LDL Cholesterol 0.1 0.1 0.2 0.2 -0.5
Lupus 3.5 5.4 6.3 -2.1 2.5
Neuroticism (2016) 0.0 0.0 0.0 0.1 -0.1
Primary Biliary Cirrhosis 0.2 0.2 0.3 0.4 -0.6
Rheumatoid Arthritis 2.1 2.9 3.7 -1.9 1.4
Schizophrenia (2014) 0.0 0.1 0.1 0.1 -0.4
Triglycerides 0.3 0.5 0.9 -0.2 -1.0
Type 2 Diabetes (T2D) (2012) 1.0 1.1 2.1 -0.3 1.5
Ulcerative Colitis 0.1 0.1 0.2 0.2 0.5
Blood Eosinophil Count 0.7 5.2 5.3 2.3 -2.3
Blood Platelet Count 0.1 1.7 2.9 -0.6 1.7
Blood Red Count 0.3 2.6 3.2 1.4 -1.8
Blood White Count 0.3 2.1 2.6 1.2 -1.6
Heel T-Score 0.4 3.4 4.2 2.0 -1.6
BMI 0.8 4.8 4.9 2.2 -2.2
Height 18.5 356.0 416.2 -17.2 20.4
Waist Hip Ratio (WHR) 0.3 1.2 1.5 0.9 -1.2
Systolic Blood Pressure 0.2 1.2 1.8 -0.8 1.3
Smoking Status 0.1 0.3 0.5 0.4 -0.7
Allergy or Eczema 0.8 2.1 2.5 -1.3 1.6
Cardiovascular Disease 1.5 5.0 5.0 2.2 -2.2
Hypothyroidism (self reported) 0.7 1.5 2.0 1.0 -1.4
Respiratory disease 0.5 1.0 1.8 -0.5 1.3
Type 2 Diabetes (T2D) (2018) 0.6 1.2 1.4 -1.2 1.0
Lung FEV1/FVC ratio 1.7 8.6 11.7 -2.4 3.4
Lung FVC 5.0 25.6 29.6 4.6 -5.4
Neuroticism 0.2 0.4 0.7 0.9 -0.4
Chronotype (morning person) 0.9 2.2 3.0 -1.2 1.7
Hair Pigment 1.9 54.0 63.5 6.7 -8.0
Tanning 6.2 75.3 92.0 -7.7 9.6
Hand grip strength (left) 8.2 21.5 25.3 -4.2 5.0
Number of treatments/medications taken 2.2 3.9 5.2 1.6 -2.3
Average weekly spirits intake 0.3 0.3 0.4 0.5 -0.7
Sensitivity / hurt feelings 0.0 0.1 0.1 -0.0 -0.4
Frequency of depressed mood in last 2 weeks 0.9 1.2 1.6 0.9 -1.3
Hearing difficulty/problems: Yes 1.5 2.3 3.0 -1.2 1.7
Relative age of first facial hair 0.1 0.2 0.3 -0.6 -0.2
Other serious medical condition/disability diagnosed by doctor 2.2 2.9 3.0 1.7 -1.7
Ever used hormone-replacement therapy (HRT) 2.3 2.9 3.3 1.8 -1.6
Ever had hysterectomy (womb removed) 0.0 0.0 0.0 -0.1 0.1
Systolic blood pressure, automated reading 0.1 0.3 0.5 -0.2 0.7
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 2.3 -1.0 1.5
Angina 0.3 0.4 0.8 -0.9 0.2
Medication for hormone replacement therapy 0.4 0.4 0.7 0.8 -0.5
Vitamin and mineral supplements 0.1 0.2 0.3 0.1 -0.5
Supplements: Zinc 0.0 0.0 0.1 -0.1 0.3
Medication: Co-codamol 4.4 5.1 6.1 2.5 -2.0
Medication: Metformin 0.4 0.6 0.7 -0.6 0.9
Diabetes (father) 0.1 0.1 0.1 -0.4 -0.2
Diabetes (mother) 1.1 1.5 2.2 0.9 -1.5
Severe depression (siblings) 0.0 0.0 0.1 0.3 -0.0
Pack years adult smoking proportion 0.3 0.4 0.6 0.8 -0.5
Impedance of leg (right) 3.0 14.6 15.2 3.7 -3.9
Leg fat-free mass (left) 11.3 59.9 67.9 -7.2 8.2
Trunk fat percentage 1.0 4.2 5.2 1.8 -2.3
Hand grip strength (right) 10.9 29.6 36.4 -4.8 6.0
Townsend deprivation index at recruitment 0.1 0.1 0.1 0.3 -0.3
Current tobacco smoking 0.6 0.9 0.9 1.0 -1.0
Average weekly fortified wine intake 0.2 0.2 0.3 -0.1 0.6
Maternal smoking around birth 0.4 0.6 0.9 0.7 -0.9
Fed-up feelings 1.1 1.9 2.6 1.1 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.1 0.2 0.3 0.4 -0.5
Relative age voice broke 0.5 0.7 1.3 -1.1 0.3
Taking other prescription medications 0.5 0.7 0.8 0.7 -0.9
Age when periods started (menarche) 7.6 18.3 18.6 -4.2 4.3
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.1 0.3 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 1.8 1.3 -0.9
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.1 -0.4 -0.0
Qualifications: CSEs or equivalent 1.2 1.6 2.4 0.9 -1.5
Serious illness, injury or assault to yourself 0.1 0.1 0.3 0.1 -0.5
High blood pressure 0.6 1.8 2.1 1.2 -1.4
Hayfever, allergic rhinitis or eczema 1.8 4.0 4.0 -2.0 2.0
Multivitamins +/- minerals 0.7 0.9 1.0 -0.8 1.0
Stomach or abdominal pain in last month 2.7 3.3 4.0 1.6 -2.0
Supplements: Glucosamine 0.0 0.0 0.0 0.1 0.2
Diverticular disease/diverticulitis (self-reported) 3.1 3.7 5.1 2.3 -1.5
Medication: Atenolol 2.0 2.5 3.4 -1.8 1.3
Medication: Levothyroxine sodium 0.4 0.7 0.8 0.8 -0.9
Sitting height 27.6 195.7 225.0 -12.9 15.0
Chronic bronchitis/emphysema (father) 2.1 2.5 4.0 1.0 -2.0
High blood pressure (mother) 0.4 0.5 0.6 -0.8 0.7
Body mass index (BMI) 1.4 5.8 6.8 2.2 -2.6
Impedance of leg (left) 2.9 13.9 14.5 3.8 -3.6
Leg predicted mass (left) 11.4 60.6 68.6 -7.3 8.3
Trunk fat mass 0.2 0.8 0.9 -0.8 0.9
Waist circumference 0.0 0.1 0.1 -0.2 0.3
Number of incorrect matches in round 0.3 0.5 0.8 0.5 -0.9
Past tobacco smoking 0.1 0.1 0.2 0.2 0.4
Alcohol usually taken with meals 1.6 2.6 3.7 -1.2 1.9
Nervous feelings 0.1 0.1 0.3 -0.0 0.5
Frequency of tenseness / restlessness in last 2 weeks 4.4 6.8 7.3 2.7 -2.5
Hearing difficulty/problems with background noise 0.4 0.7 0.7 -0.8 0.8
Hair/balding pattern: Pattern 2 1.6 2.0 2.3 1.3 -1.5
Had menopause 0.3 0.4 0.5 -0.5 0.7
Had other major operations 0.4 0.5 0.8 -0.9 -0.3
Forced vital capacity (FVC) 1.9 7.2 9.2 -2.3 3.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 2.4 1.5 -0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 0.8 0.9 -0.6
Qualifications: None of the above 2.1 4.5 5.5 1.9 -2.4
Financial difficulties in last 2 years 1.8 2.5 2.6 1.5 -1.6
Mouth/teeth dental problems 2.3 3.5 5.0 -1.4 2.2
Heart attack 0.2 0.2 0.4 0.3 -0.6
Allergy 1.3 3.0 4.2 1.3 -2.1
Pain all over the body in last month 0.3 0.3 0.7 0.2 -0.8
Diabetes (self-reported) 0.1 0.1 0.1 -0.3 0.3
Hayfever/allergic rhinitis (self-reported) 2.9 3.9 5.0 -1.6 2.2
Medication: Ramipril 2.7 3.4 4.9 -2.2 1.4
Medication: Simvastatin 0.5 0.7 1.3 -1.2 0.1
Fluid intelligence score 0.1 0.2 0.3 0.2 0.6
Illnesses of siblings 1.6 2.2 2.9 -1.7 1.3
Neuroticism score 0.1 0.2 0.2 0.4 -0.4
Weight 3.7 18.0 21.0 -3.9 4.6
Impedance of arm (right) 1.5 6.8 8.3 2.3 -2.9
Arm fat percentage (right) 3.1 12.2 15.1 3.0 -3.9
Trunk fat-free mass 19.1 109.5 127.7 -9.6 11.3
Hip circumference 1.1 4.7 5.4 -2.0 2.3
Time employed in main current job 0.5 0.6 0.9 0.5 -1.0
Alcohol intake versus 10 years previously 0.7 1.1 1.3 -1.1 0.9
Father’s age at death 0.3 0.5 0.7 -0.5 0.8
Worrier / anxious feelings 0.4 0.7 0.8 -0.7 0.9
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.5 1.6 1.2 -1.3
Falls in the last year 0.2 0.3 0.3 0.6 -0.6
Hair/balding pattern: Pattern 3 1.2 1.8 2.2 -1.5 1.2
Number of live births 1.1 1.6 1.9 1.1 -1.4
Forced expiratory volume in 1-second (FEV1) 2.1 6.9 8.7 -2.3 3.0
Pulse rate 3.3 5.6 6.9 2.6 -2.1
Happiness 0.3 0.3 0.6 0.2 -0.8
Noisy workplace 0.5 0.6 1.2 0.2 -1.1
Qualifications: A levels/AS levels or equivalent 1.1 2.5 2.5 -1.6 1.6
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 0.9 -1.0 0.9
Mouth/teeth dental problems: Dentures 0.6 0.9 1.6 -1.3 0.5
Asthma 0.2 0.4 0.7 0.0 0.8
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.4 -0.6 0.2
Medication: Cholesterol lowering 0.5 0.8 1.4 0.4 -1.2
Depression (self-reported) 0.1 0.1 0.1 0.3 -0.2
Medication: Lansoprazole 0.3 0.3 0.6 -0.1 -0.8
Prospective memory result 0.7 0.9 1.7 -1.3 0.3
Lung cancer (father) 1.0 1.1 1.7 -1.3 0.8
Illnesses of mother 0.8 1.0 1.4 -0.7 1.2
Forced expiratory volume in 1-second (FEV1), Best measure 3.2 10.1 12.1 -2.8 3.5
Pulse wave Arterial Stiffness index 0.0 0.0 0.1 0.3 -0.1
Impedance of arm (left) 1.2 5.8 6.8 2.2 -2.6
Arm fat mass (right) 0.0 0.2 0.2 0.3 -0.5
Trunk predicted mass 19.2 109.8 127.7 -9.6 11.3
Standing height 21.9 216.9 255.8 -13.3 16.0
Length of working week for main job 1.2 1.4 1.8 -1.3 1.0
Exposure to tobacco smoke at home 1.5 1.7 2.3 1.5 -1.1
Breastfed as a baby 1.4 1.7 2.1 -1.5 1.1
Tense / ‘highly strung’ 0.1 0.1 0.1 0.4 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 0.7 0.7 -0.8
Hair/balding pattern: Pattern 4 0.1 0.2 0.3 -0.2 0.5
Birth weight of first child 0.1 0.2 0.2 -0.4 -0.4
Peak expiratory flow (PEF) 3.3 7.7 10.0 -2.3 3.2
Pulse wave reflection index 0.3 0.4 0.5 -0.5 0.7
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.2 -0.4 -0.3
Loud music exposure frequency 0.1 0.1 0.3 -0.0 -0.5
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 1.8 -1.1 1.4
Mouth/teeth dental problems: Bleeding gums 6.0 7.7 7.8 2.8 -2.8
Blood clot in the leg (DVT) 3.2 4.1 5.4 -1.7 2.3
Medication: Paracetamol 0.6 0.9 1.2 0.8 -1.1
Headache pain in last month 0.8 1.3 1.6 -1.3 1.0
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 0.8 -0.3 0.9
Glaucoma (self-reported) 0.1 0.1 0.3 0.5 0.2
Gout (self-reported) 0.0 0.0 0.0 -0.2 0.2
Hypothyroidism/myxoedema (self-reported) 1.1 2.2 2.5 1.4 -1.6
Medication: Amlodipine 0.0 0.0 0.1 -0.1 -0.3
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.4 0.1
Birth weight 2.2 4.8 5.4 -2.3 2.0
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.1 -0.2 -0.4
High blood pressure (siblings) 0.1 0.2 0.3 0.5 0.1
Forced vital capacity (FVC), Best measure 3.1 11.3 13.6 -3.0 3.7
Body fat percentage 2.4 9.3 11.2 2.7 -3.3
Leg fat percentage (right) 5.5 19.8 23.6 4.0 -4.9
Arm fat-free mass (right) 16.0 82.0 96.8 -8.2 9.8
Exposure to tobacco smoke outside home 0.5 0.6 0.8 0.9 -0.7
Comparative body size at age 10 2.6 7.2 7.4 2.6 -2.7
Number of full brothers 0.3 0.4 0.7 0.9 0.3
Worry too long after embarrassment 0.0 0.0 0.0 0.1 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.3 0.3 -0.5
Wheeze or whistling in the chest in last year 0.6 1.2 1.2 -1.0 1.1
Number of children fathered 1.1 1.2 1.8 -1.3 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.6 0.1
Age at first live birth 1.6 2.8 3.7 -1.3 1.9
Pulse wave peak to peak time 0.6 0.8 0.9 -1.0 0.8
Health satisfaction 0.1 0.2 0.3 0.3 -0.6
Shortness of breath walking on level ground 2.3 2.7 2.9 1.6 -1.7
Qualifications: College or University degree 2.3 7.4 9.7 -2.2 3.1
Eye problems/disorders: None of the above 0.1 0.1 0.1 -0.3 0.3
Mouth/teeth dental problems: Loose teeth 0.0 0.0 0.0 0.2 0.1
Emphysema/chronic bronchitis 0.5 0.6 0.7 -0.8 0.7
Medication for pain relief, constipation, heartburn 1.0 1.7 2.7 -0.9 1.6
Neck or shoulder pain in last month 0.6 0.8 0.8 0.9 -0.9
Medication: Blood pressure 0.1 0.2 0.3 0.2 -0.6
Angina (self-reported) 0.3 0.4 0.8 -0.9 0.3
Migraine (self-reported) 0.1 0.2 0.3 0.6 0.2
Medication: Ibuprofen 0.1 0.1 0.2 -0.4 0.2
Medication: Allopurinol 0.2 0.3 0.5 0.7 -0.2
Medication: Omeprazole 0.2 0.2 0.2 0.4 -0.4
Medication: Seretide 50 evohaler 0.2 0.2 0.2 0.5 0.4
Mean time to correctly identify matches 4.0 7.6 8.5 2.6 -2.9
Heart disease (mother) 1.4 1.8 2.8 0.8 -1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 0.3 0.5 -0.6
Whole body fat mass 0.0 0.2 0.2 -0.4 0.4
Leg fat mass (right) 0.3 1.0 1.1 0.9 -1.1
Arm predicted mass (right) 16.0 81.9 96.4 -8.2 9.8
Pulse rate, automated reading 1.8 5.8 7.6 2.8 -2.0
Alcohol intake frequency. 0.2 0.5 0.6 0.6 -0.8
Comparative height size at age 10 9.3 51.5 62.7 -6.3 7.9
Number of full sisters 6.0 7.3 8.0 2.6 -2.8
Suffer from ‘nerves’ 0.1 0.1 0.2 0.4 -0.0
Overall health rating 2.6 5.5 7.4 1.9 -2.7
Chest pain or discomfort 0.0 0.0 0.1 0.2 -0.1
Had major operations 0.7 0.8 1.0 1.0 -0.8
Age at last live birth 1.2 1.8 2.8 -0.8 1.7
Family relationship satisfaction 0.0 0.1 0.1 0.1 -0.3
Leg pain on walking 0.3 0.4 0.6 0.5 -0.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 0.3 -0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 0.7 0.6 -0.8
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.1 0.4
Medication: Aspirin 3.4 4.4 4.9 2.0 -2.2
Supplements: Vitamin C 0.2 0.2 0.3 0.6 -0.2
Knee pain experienced in last month 8.8 13.6 18.4 3.0 -4.3
Hypertension (Self-reported) 0.7 1.9 2.5 1.2 -1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.1 -0.5
Illnesses of father: Heart disease 3.1 4.3 4.6 2.1 -2.0
Illnesses of siblings: Diabetes 1.5 1.8 2.3 1.5 -1.1
Smoking status: Previous 0.0 0.1 0.1 -0.3 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 9.3 19.4 20.1 -4.3 4.5
Whole body fat-free mass 16.7 95.5 110.2 -9.0 10.5
Leg fat-free mass (right) 12.5 66.7 76.9 -7.5 8.8
Arm fat percentage (left) 3.0 12.0 14.9 3.0 -3.9
Average weekly red wine intake 2.2 3.3 3.3 -1.8 1.8
Handedness (chirality/laterality): Left-handed 1.0 1.2 1.3 -1.2 1.1
Mood swings 0.3 0.5 0.6 0.8 -0.6
Loneliness, isolation 4.4 6.1 7.1 2.2 -2.7
Long-standing illness, disability or infirmity 0.1 0.1 0.2 -0.5 0.1
Ever had bowel cancer screening 0.2 0.2 0.2 0.4 -0.5
Diabetes diagnosed by doctor 0.1 0.1 0.2 -0.4 0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 2.3 1.5 -1.2
Friendships satisfaction 2.7 3.4 4.5 1.5 -2.1
Qualifications: nursing, teaching 0.1 0.2 0.3 -0.1 0.6
Commuting to job workplace: Walk 5.4 5.8 7.9 -1.9 2.8
Eye problems/disorders: Cataract 0.2 0.2 0.3 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 1.5 2.4 2.6 1.6 -1.5
Medication for cholesterol 0.1 0.1 0.2 -0.0 0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.6 0.8 -0.8
Back pain experienced in last month 0.2 0.3 0.6 -0.7 0.0
Mineral and other dietary supplements 0.3 0.4 0.7 -0.9 -0.2
Breast cancer (self-reported) 0.2 0.3 0.5 -0.3 0.7
Asthma (self-reported) 0.1 0.2 0.3 0.3 0.6
Osteoporosis (self-reported) 1.9 2.3 2.5 1.6 -1.5
Osteoarthritis (self-reported) 2.8 3.6 3.7 1.9 -1.9
Medication: Aspirin 2.9 3.8 4.3 1.8 -2.1
Medication: Gliclazide 0.1 0.1 0.2 0.4 -0.1
Illnesses of father: None of the above (group 1) 3.0 3.7 4.3 -1.7 2.1
Smoking status: Current 0.4 0.7 0.7 0.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.1 0.2 0.3 0.4 -0.5
Whole body water mass 16.5 93.9 108.2 -8.9 10.4
Leg predicted mass (right) 12.6 67.1 77.1 -7.6 8.8
Arm fat mass (left) 0.0 0.0 0.0 -0.1 -0.0
Number of self-reported non-cancer illnesses 2.6 4.5 4.5 2.1 -2.1
Average weekly champagne plus white wine intake 0.2 0.2 0.5 0.0 0.7
Miserableness 1.8 3.1 3.3 1.8 -1.7
Guilty feelings 0.5 0.8 0.9 -0.8 0.9
Wears glasses or contact lenses 3.5 4.1 4.7 -1.9 2.2
Ever taken oral contraceptive pill 0.3 0.4 0.7 0.9 -0.1
Hearing aid user 1.4 1.6 1.7 -1.3 1.2
Mother’s age at death 0.1 0.1 0.1 -0.4 0.1
Financial situation satisfaction 0.4 0.5 0.9 -0.9 -0.1
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.5 -0.4 0.7
Commuting to job workplace: Public transport 0.8 0.9 0.9 -1.0 1.0
Eye problems/disorders: Glaucoma 0.2 0.2 0.3 0.5 -0.4
Medication: Blood pressure 0.2 0.4 0.7 -0.8 0.3
Pain type(s) experienced in last month: Hip pain 6.6 8.3 8.3 2.9 -2.9
Supplements: Fish oil (including cod liver oil) 0.2 0.3 0.3 0.5 0.5
High cholesterol (Self-reported) 0.7 1.2 2.2 0.4 -1.5
Medication: Bendroflumethiazide 0.1 0.2 0.2 -0.4 0.4
Medication: Paracetamol 0.8 1.3 1.4 1.2 -1.1
Medication: Lisinopril 0.2 0.3 0.6 -0.1 -0.8
Medication: Atorvastatin 0.8 0.9 1.7 0.4 -1.3
Illnesses of father: High blood pressure 0.0 0.0 0.1 0.0 -0.2
Alcohol drinker status: Never 0.4 0.5 0.5 0.7 -0.7
Ever smoked 0.1 0.2 0.2 -0.5 0.4
Basal metabolic rate 13.0 71.8 83.0 -7.8 9.1
Leg fat percentage (left) 5.0 18.1 20.4 4.0 -4.5
Arm fat-free mass (left) 14.8 74.9 86.7 -7.9 9.3
Number of operations (self-reported) 1.6 2.4 2.7 1.5 -1.6
Average weekly beer plus cider intake 1.3 1.9 2.1 1.4 -1.3
Irritability 1.4 2.4 2.9 -1.4 1.7
Risk taking 0.0 0.0 0.0 -0.1 0.1
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.1 0.4 0.2
Fractured/broken bones in last 5 years 0.0 0.0 0.0 0.2 0.0
Age started oral contraceptive pill 5.7 7.2 7.5 -2.7 2.6
Diastolic blood pressure, automated reading 3.0 9.2 10.3 3.2 -2.8
Ever depressed for a whole week 2.1 2.6 2.9 1.5 -1.7
Unable to work because of sickness or disability 1.6 2.1 3.2 1.0 -1.8
Commuting to job workplace: Cycle 0.2 0.3 0.4 -0.4 0.6
Myopia 5.9 8.5 9.3 -2.8 3.0
Vascular/heart problems diagnosed by doctor 1.1 3.1 3.4 -1.7 1.9
Cholesterol lowering medication 0.3 0.5 0.9 -1.0 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 0.7 0.8 -0.7
Pain experienced in last month 1.9 3.2 4.2 -1.5 2.1
Supplements: Calcium 0.5 0.5 0.7 0.6 -0.8
Basal cell carcinoma (self-reported) 2.4 2.8 3.2 1.8 -1.5
Heart attack/myocardial infarction (self-reported) 0.0 0.1 0.1 0.1 -0.3
Deep venous thrombosis (DVT) (self-reported) 3.9 5.0 7.0 -1.7 2.6
Heart disease (siblings) 1.2 1.4 1.5 1.2 -1.2
Alcohol drinker status: Previous 0.7 0.8 1.3 -1.1 0.6
Pack years of smoking 0.2 0.3 0.4 0.7 -0.5
Impedance of whole body 1.8 9.1 9.8 2.9 -3.1
Leg fat mass (left) 0.1 0.5 0.6 0.8 -0.7
Arm predicted mass (left) 13.9 70.8 83.0 -7.7 9.1