TWAS hub - ROMO1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	ROSMAP	Brain Pre-frontal Cortex	0.0599	0.0294	0.0024	0.023	0.006	0.011	0.011	0.010	5.3e-04	5.4e-02	1.2e-02	1.2e-02	1.7e-02
2	YFS	Blood	0.1141	0.0261	0.0000	0.150	0.170	0.173	0.168	0.172	1.1e-46	3.7e-53	2.3e-54	1.4e-52	6.2e-54

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Sitting height	27.6	195.7	225.0	-12.9	15.0
Standing height	21.9	216.9	255.8	-13.3	16.0
Trunk predicted mass	19.2	109.8	127.7	-9.6	11.3
Trunk fat-free mass	19.1	109.5	127.7	-9.6	11.3
Height	18.5	356.0	416.2	-17.2	20.4
Whole body fat-free mass	16.7	95.5	110.2	-9.0	10.5
Whole body water mass	16.5	93.9	108.2	-8.9	10.4
Arm fat-free mass (right)	16.0	82.0	96.8	-8.2	9.8
Arm predicted mass (right)	16.0	81.9	96.4	-8.2	9.8
Arm fat-free mass (left)	14.8	74.9	86.7	-7.9	9.3
Arm predicted mass (left)	13.9	70.8	83.0	-7.7	9.1
Basal metabolic rate	13.0	71.8	83.0	-7.8	9.1
Leg predicted mass (right)	12.6	67.1	77.1	-7.6	8.8
Leg fat-free mass (right)	12.5	66.7	76.9	-7.5	8.8
Leg predicted mass (left)	11.4	60.6	68.6	-7.3	8.3
Leg fat-free mass (left)	11.3	59.9	67.9	-7.2	8.2
Hand grip strength (right)	10.9	29.6	36.4	-4.8	6.0
Comparative height size at age 10	9.3	51.5	62.7	-6.3	7.9
Forced expiratory volume in 1-second (FEV1), predicted	9.3	19.4	20.1	-4.3	4.5
Knee pain experienced in last month	8.8	13.6	18.4	3.0	-4.3
Hand grip strength (left)	8.2	21.5	25.3	-4.2	5.0
Age when periods started (menarche)	7.6	18.3	18.6	-4.2	4.3
Pain type(s) experienced in last month: Hip pain	6.6	8.3	8.3	2.9	-2.9
Tanning	6.2	75.3	92.0	-7.7	9.6
Mouth/teeth dental problems: Bleeding gums	6.0	7.7	7.8	2.8	-2.8
Number of full sisters	6.0	7.3	8.0	2.6	-2.8
Myopia	5.9	8.5	9.3	-2.8	3.0
Age started oral contraceptive pill	5.7	7.2	7.5	-2.7	2.6
Leg fat percentage (right)	5.5	19.8	23.6	4.0	-4.9
Commuting to job workplace: Walk	5.4	5.8	7.9	-1.9	2.8
Reaction Time	5.1	9.8	11.7	2.8	-3.4
Lung FVC	5.0	25.6	29.6	4.6	-5.4
Leg fat percentage (left)	5.0	18.1	20.4	4.0	-4.5
Medication: Co-codamol	4.4	5.1	6.1	2.5	-2.0
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.8	7.3	2.7	-2.5
Loneliness, isolation	4.4	6.1	7.1	2.2	-2.7
Mean time to correctly identify matches	4.0	7.6	8.5	2.6	-2.9
Deep venous thrombosis (DVT) (self-reported)	3.9	5.0	7.0	-1.7	2.6
Weight	3.7	18.0	21.0	-3.9	4.6
Lupus	3.5	5.4	6.3	-2.1	2.5
Wears glasses or contact lenses	3.5	4.1	4.7	-1.9	2.2
Medication: Aspirin	3.4	4.4	4.9	2.0	-2.2
Pulse rate	3.3	5.6	6.9	2.6	-2.1
Peak expiratory flow (PEF)	3.3	7.7	10.0	-2.3	3.2
Age at First Birth	3.2	4.7	4.7	-2.2	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.2	10.1	12.1	-2.8	3.5
Blood clot in the leg (DVT)	3.2	4.1	5.4	-1.7	2.3
Diverticular disease/diverticulitis (self-reported)	3.1	3.7	5.1	2.3	-1.5
Arm fat percentage (right)	3.1	12.2	15.1	3.0	-3.9
Forced vital capacity (FVC), Best measure	3.1	11.3	13.6	-3.0	3.7
Illnesses of father: Heart disease	3.1	4.3	4.6	2.1	-2.0
Impedance of leg (right)	3.0	14.6	15.2	3.7	-3.9
Arm fat percentage (left)	3.0	12.0	14.9	3.0	-3.9
Illnesses of father: None of the above (group 1)	3.0	3.7	4.3	-1.7	2.1
Diastolic blood pressure, automated reading	3.0	9.2	10.3	3.2	-2.8
Impedance of leg (left)	2.9	13.9	14.5	3.8	-3.6
Hayfever/allergic rhinitis (self-reported)	2.9	3.9	5.0	-1.6	2.2
Medication: Aspirin	2.9	3.8	4.3	1.8	-2.1
Osteoarthritis (self-reported)	2.8	3.6	3.7	1.9	-1.9
Stomach or abdominal pain in last month	2.7	3.3	4.0	1.6	-2.0
Medication: Ramipril	2.7	3.4	4.9	-2.2	1.4
Friendships satisfaction	2.7	3.4	4.5	1.5	-2.1
Comparative body size at age 10	2.6	7.2	7.4	2.6	-2.7
Overall health rating	2.6	5.5	7.4	1.9	-2.7
Number of self-reported non-cancer illnesses	2.6	4.5	4.5	2.1	-2.1
Body fat percentage	2.4	9.3	11.2	2.7	-3.3
Basal cell carcinoma (self-reported)	2.4	2.8	3.2	1.8	-1.5
Ever used hormone-replacement therapy (HRT)	2.3	2.9	3.3	1.8	-1.6
Mouth/teeth dental problems	2.3	3.5	5.0	-1.4	2.2
Shortness of breath walking on level ground	2.3	2.7	2.9	1.6	-1.7
Qualifications: College or University degree	2.3	7.4	9.7	-2.2	3.1
Alzheimer’s Disease (in father)	2.2	2.4	2.8	1.4	-1.7
Number of treatments/medications taken	2.2	3.9	5.2	1.6	-2.3
Other serious medical condition/disability diagnosed by doctor	2.2	2.9	3.0	1.7	-1.7
Birth weight	2.2	4.8	5.4	-2.3	2.0
Average weekly red wine intake	2.2	3.3	3.3	-1.8	1.8
Rheumatoid Arthritis	2.1	2.9	3.7	-1.9	1.4
Chronic bronchitis/emphysema (father)	2.1	2.5	4.0	1.0	-2.0
Qualifications: None of the above	2.1	4.5	5.5	1.9	-2.4
Forced expiratory volume in 1-second (FEV1)	2.1	6.9	8.7	-2.3	3.0
Ever depressed for a whole week	2.1	2.6	2.9	1.5	-1.7
Medication: Atenolol	2.0	2.5	3.4	-1.8	1.3
Hair Pigment	1.9	54.0	63.5	6.7	-8.0
Forced vital capacity (FVC)	1.9	7.2	9.2	-2.3	3.0
Osteoporosis (self-reported)	1.9	2.3	2.5	1.6	-1.5
Pain experienced in last month	1.9	3.2	4.2	-1.5	2.1
Bipolar Disorder (2018)	1.8	2.8	3.6	1.9	-1.4
Hayfever, allergic rhinitis or eczema	1.8	4.0	4.0	-2.0	2.0
Financial difficulties in last 2 years	1.8	2.5	2.6	1.5	-1.6
Pulse rate, automated reading	1.8	5.8	7.6	2.8	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	2.3	1.5	-1.2
Miserableness	1.8	3.1	3.3	1.8	-1.7
Impedance of whole body	1.8	9.1	9.8	2.9	-3.1
Lung FEV1/FVC ratio	1.7	8.6	11.7	-2.4	3.4
Alcohol usually taken with meals	1.6	2.6	3.7	-1.2	1.9
Hair/balding pattern: Pattern 2	1.6	2.0	2.3	1.3	-1.5
Illnesses of siblings	1.6	2.2	2.9	-1.7	1.3
Age at first live birth	1.6	2.8	3.7	-1.3	1.9
Number of operations (self-reported)	1.6	2.4	2.7	1.5	-1.6
Unable to work because of sickness or disability	1.6	2.1	3.2	1.0	-1.8
Cardiovascular Disease	1.5	5.0	5.0	2.2	-2.2
Hearing difficulty/problems: Yes	1.5	2.3	3.0	-1.2	1.7
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	2.3	-1.0	1.5
Impedance of arm (right)	1.5	6.8	8.3	2.3	-2.9
Exposure to tobacco smoke at home	1.5	1.7	2.3	1.5	-1.1
Illnesses of siblings: Diabetes	1.5	1.8	2.3	1.5	-1.1
Mouth/teeth dental problems: Mouth ulcers	1.5	2.4	2.6	1.6	-1.5
Major Depression (MDD)	1.4	1.6	2.1	1.1	-1.4
Body mass index (BMI)	1.4	5.8	6.8	2.2	-2.6
Breastfed as a baby	1.4	1.7	2.1	-1.5	1.1
Heart disease (mother)	1.4	1.8	2.8	0.8	-1.7
Hearing aid user	1.4	1.6	1.7	-1.3	1.2
Irritability	1.4	2.4	2.9	-1.4	1.7
Allergy	1.3	3.0	4.2	1.3	-2.1
Average weekly beer plus cider intake	1.3	1.9	2.1	1.4	-1.3
Qualifications: CSEs or equivalent	1.2	1.6	2.4	0.9	-1.5
Hair/balding pattern: Pattern 3	1.2	1.8	2.2	-1.5	1.2
Impedance of arm (left)	1.2	5.8	6.8	2.2	-2.6
Length of working week for main job	1.2	1.4	1.8	-1.3	1.0
Age at last live birth	1.2	1.8	2.8	-0.8	1.7
Heart disease (siblings)	1.2	1.4	1.5	1.2	-1.2
Diabetes (mother)	1.1	1.5	2.2	0.9	-1.5
Fed-up feelings	1.1	1.9	2.6	1.1	-1.6
Hip circumference	1.1	4.7	5.4	-2.0	2.3
Number of live births	1.1	1.6	1.9	1.1	-1.4
Qualifications: A levels/AS levels or equivalent	1.1	2.5	2.5	-1.6	1.6
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	2.5	1.4	-1.6
Number of children fathered	1.1	1.2	1.8	-1.3	0.8
Vascular/heart problems diagnosed by doctor	1.1	3.1	3.4	-1.7	1.9
HbA1C	1.0	1.1	1.5	1.2	-0.9
Type 2 Diabetes (T2D) (2012)	1.0	1.1	2.1	-0.3	1.5
Trunk fat percentage	1.0	4.2	5.2	1.8	-2.3
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.5	1.6	1.2	-1.3
Lung cancer (father)	1.0	1.1	1.7	-1.3	0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	1.8	-1.1	1.4
Medication for pain relief, constipation, heartburn	1.0	1.7	2.7	-0.9	1.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.3	-1.2	1.1
Chronotype (morning person)	0.9	2.2	3.0	-1.2	1.7
Frequency of depressed mood in last 2 weeks	0.9	1.2	1.6	0.9	-1.3
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.6	-1.1	1.9
BMI	0.8	4.8	4.9	2.2	-2.2
Allergy or Eczema	0.8	2.1	2.5	-1.3	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	0.9	-1.0	0.9
Illnesses of mother	0.8	1.0	1.4	-0.7	1.2
Headache pain in last month	0.8	1.3	1.6	-1.3	1.0
Commuting to job workplace: Public transport	0.8	0.9	0.9	-1.0	1.0
Medication: Paracetamol	0.8	1.3	1.4	1.2	-1.1
Medication: Atorvastatin	0.8	0.9	1.7	0.4	-1.3
Alzheimer’s Disease (including proxy)	0.7	1.1	1.4	0.8	-1.2
Mean Putamen Volume	0.7	0.8	0.9	-0.9	0.9
Blood Eosinophil Count	0.7	5.2	5.3	2.3	-2.3
Hypothyroidism (self reported)	0.7	1.5	2.0	1.0	-1.4
Multivitamins +/- minerals	0.7	0.9	1.0	-0.8	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.4	1.5	-0.8
Alcohol intake versus 10 years previously	0.7	1.1	1.3	-1.1	0.9
Prospective memory result	0.7	0.9	1.7	-1.3	0.3
Had major operations	0.7	0.8	1.0	1.0	-0.8
Hypertension (Self-reported)	0.7	1.9	2.5	1.2	-1.6
High cholesterol (Self-reported)	0.7	1.2	2.2	0.4	-1.5
Alcohol drinker status: Previous	0.7	0.8	1.3	-1.1	0.6
Crohns Disease (2017)	0.6	1.4	1.4	-1.2	1.2
Irritable Bowel Disease (IBD)	0.6	1.5	1.7	-1.1	1.3
Fasting Glucose	0.6	0.7	1.0	-0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.2	1.4	-1.2	1.0
Current tobacco smoking	0.6	0.9	0.9	1.0	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	1.8	1.3	-0.9
High blood pressure	0.6	1.8	2.1	1.2	-1.4
Mouth/teeth dental problems: Dentures	0.6	0.9	1.6	-1.3	0.5
Medication: Paracetamol	0.6	0.9	1.2	0.8	-1.1
Wheeze or whistling in the chest in last year	0.6	1.2	1.2	-1.0	1.1
Pulse wave peak to peak time	0.6	0.8	0.9	-1.0	0.8
Neck or shoulder pain in last month	0.6	0.8	0.8	0.9	-0.9
Bipolar Disorder or Schizophrenia	0.5	1.3	1.5	1.2	-1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.1	2.0	-0.4	1.4
Coronary Artery Disease (CAD)	0.5	0.7	1.1	0.4	-1.1
Respiratory disease	0.5	1.0	1.8	-0.5	1.3
Relative age voice broke	0.5	0.7	1.3	-1.1	0.3
Taking other prescription medications	0.5	0.7	0.8	0.7	-0.9
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	0.8	0.9	-0.6
Medication: Simvastatin	0.5	0.7	1.3	-1.2	0.1
Time employed in main current job	0.5	0.6	0.9	0.5	-1.0
Noisy workplace	0.5	0.6	1.2	0.2	-1.1
Medication: Cholesterol lowering	0.5	0.8	1.4	0.4	-1.2
Exposure to tobacco smoke outside home	0.5	0.6	0.8	0.9	-0.7
Emphysema/chronic bronchitis	0.5	0.6	0.7	-0.8	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.6	0.8	-0.8
Guilty feelings	0.5	0.8	0.9	-0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	0.7	0.8	-0.7
Supplements: Calcium	0.5	0.5	0.7	0.6	-0.8
Depressed Affect (Nagel 2018)	0.4	0.9	0.9	0.9	-0.9
Heel T-Score	0.4	3.4	4.2	2.0	-1.6
Medication for hormone replacement therapy	0.4	0.4	0.7	0.8	-0.5
Medication: Metformin	0.4	0.6	0.7	-0.6	0.9
Maternal smoking around birth	0.4	0.6	0.9	0.7	-0.9
Medication: Levothyroxine sodium	0.4	0.7	0.8	0.8	-0.9
High blood pressure (mother)	0.4	0.5	0.6	-0.8	0.7
Hearing difficulty/problems with background noise	0.4	0.7	0.7	-0.8	0.8
Had other major operations	0.4	0.5	0.8	-0.9	-0.3
Worrier / anxious feelings	0.4	0.7	0.8	-0.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	0.7	0.7	-0.8
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.7	0.6	-0.8
Smoking status: Current	0.4	0.7	0.7	0.8	-0.8
Financial situation satisfaction	0.4	0.5	0.9	-0.9	-0.1
Alcohol drinker status: Never	0.4	0.5	0.5	0.7	-0.7
Ulcerative Colitis (UC)	0.3	0.6	0.7	-0.7	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	0.7	0.3	-0.8
Triglycerides	0.3	0.5	0.9	-0.2	-1.0
Blood Red Count	0.3	2.6	3.2	1.4	-1.8
Blood White Count	0.3	2.1	2.6	1.2	-1.6
Waist Hip Ratio (WHR)	0.3	1.2	1.5	0.9	-1.2
Average weekly spirits intake	0.3	0.3	0.4	0.5	-0.7
Angina	0.3	0.4	0.8	-0.9	0.2
Pack years adult smoking proportion	0.3	0.4	0.6	0.8	-0.5
Number of incorrect matches in round	0.3	0.5	0.8	0.5	-0.9
Had menopause	0.3	0.4	0.5	-0.5	0.7
Pain all over the body in last month	0.3	0.3	0.7	0.2	-0.8
Father’s age at death	0.3	0.5	0.7	-0.5	0.8
Happiness	0.3	0.3	0.6	0.2	-0.8
Medication: Lansoprazole	0.3	0.3	0.6	-0.1	-0.8
Pulse wave reflection index	0.3	0.4	0.5	-0.5	0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.8	-0.3	0.9
Number of full brothers	0.3	0.4	0.7	0.9	0.3
Angina (self-reported)	0.3	0.4	0.8	-0.9	0.3
Leg fat mass (right)	0.3	1.0	1.1	0.9	-1.1
Leg pain on walking	0.3	0.4	0.6	0.5	-0.7
Mood swings	0.3	0.5	0.6	0.8	-0.6
Mineral and other dietary supplements	0.3	0.4	0.7	-0.9	-0.2
Ever taken oral contraceptive pill	0.3	0.4	0.7	0.9	-0.1
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.5	-0.4	0.7
Cholesterol lowering medication	0.3	0.5	0.9	-1.0	-0.2
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	-0.6	0.2
Worry (Nagel 2018)	0.2	0.4	0.7	-0.4	0.8
Breast Cancer	0.2	0.5	1.0	-1.0	0.3
Ovarian Cancer	0.2	0.2	0.4	-0.2	-0.6
Crohns Disease (2012)	0.2	0.3	0.6	-0.3	0.8
HDL Cholesterol	0.2	0.3	0.5	0.2	-0.7
Primary Biliary Cirrhosis	0.2	0.2	0.3	0.4	-0.6
Systolic Blood Pressure	0.2	1.2	1.8	-0.8	1.3
Neuroticism	0.2	0.4	0.7	0.9	-0.4
Average weekly fortified wine intake	0.2	0.2	0.3	-0.1	0.6
Trunk fat mass	0.2	0.8	0.9	-0.8	0.9
Heart attack	0.2	0.2	0.4	0.3	-0.6
Falls in the last year	0.2	0.3	0.3	0.6	-0.6
Asthma	0.2	0.4	0.7	0.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.4	-0.6	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.3	0.3	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.6	0.1
Medication: Allopurinol	0.2	0.3	0.5	0.7	-0.2
Medication: Omeprazole	0.2	0.2	0.2	0.4	-0.4
Medication: Seretide 50 evohaler	0.2	0.2	0.2	0.5	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.3	0.5	-0.6
Alcohol intake frequency.	0.2	0.5	0.6	0.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	0.3	-0.6
Supplements: Vitamin C	0.2	0.2	0.3	0.6	-0.2
Ever had bowel cancer screening	0.2	0.2	0.2	0.4	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.3	-0.6	0.2
Back pain experienced in last month	0.2	0.3	0.6	-0.7	0.0
Breast cancer (self-reported)	0.2	0.3	0.5	-0.3	0.7
Average weekly champagne plus white wine intake	0.2	0.2	0.5	0.0	0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.5	-0.4
Medication: Blood pressure	0.2	0.4	0.7	-0.8	0.3
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.3	0.5	0.5
Medication: Lisinopril	0.2	0.3	0.6	-0.1	-0.8
Commuting to job workplace: Cycle	0.2	0.3	0.4	-0.4	0.6
Pack years of smoking	0.2	0.3	0.4	0.7	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.0	0.4
LDL Cholesterol	0.1	0.1	0.2	0.2	-0.5
Ulcerative Colitis	0.1	0.1	0.2	0.2	0.5
Blood Platelet Count	0.1	1.7	2.9	-0.6	1.7
Smoking Status	0.1	0.3	0.5	0.4	-0.7
Relative age of first facial hair	0.1	0.2	0.3	-0.6	-0.2
Systolic blood pressure, automated reading	0.1	0.3	0.5	-0.2	0.7
Vitamin and mineral supplements	0.1	0.2	0.3	0.1	-0.5
Diabetes (father)	0.1	0.1	0.1	-0.4	-0.2
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.3	0.4	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.1	-0.4	-0.0
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.1	-0.5
Past tobacco smoking	0.1	0.1	0.2	0.2	0.4
Nervous feelings	0.1	0.1	0.3	-0.0	0.5
Diabetes (self-reported)	0.1	0.1	0.1	-0.3	0.3
Fluid intelligence score	0.1	0.2	0.3	0.2	0.6
Neuroticism score	0.1	0.2	0.2	0.4	-0.4
Depression (self-reported)	0.1	0.1	0.1	0.3	-0.2
Tense / ‘highly strung’	0.1	0.1	0.1	0.4	-0.3
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.2	0.5
Birth weight of first child	0.1	0.2	0.2	-0.4	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	-0.3
Loud music exposure frequency	0.1	0.1	0.3	-0.0	-0.5
Glaucoma (self-reported)	0.1	0.1	0.3	0.5	0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	-0.4	0.1
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.2	-0.4
High blood pressure (siblings)	0.1	0.2	0.3	0.5	0.1
Health satisfaction	0.1	0.2	0.3	0.3	-0.6
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.3	0.3
Medication: Blood pressure	0.1	0.2	0.3	0.2	-0.6
Migraine (self-reported)	0.1	0.2	0.3	0.6	0.2
Medication: Ibuprofen	0.1	0.1	0.2	-0.4	0.2
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	-0.0
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.1	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.1	-0.5
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.5	0.1
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.4	0.3
Qualifications: nursing, teaching	0.1	0.2	0.3	-0.1	0.6
Medication for cholesterol	0.1	0.1	0.2	-0.0	0.5
Asthma (self-reported)	0.1	0.2	0.3	0.3	0.6
Medication: Gliclazide	0.1	0.1	0.2	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.4	-0.5
Mother’s age at death	0.1	0.1	0.1	-0.4	0.1
Medication: Bendroflumethiazide	0.1	0.2	0.2	-0.4	0.4
Ever smoked	0.1	0.2	0.2	-0.5	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.1	0.4	0.2
Leg fat mass (left)	0.1	0.5	0.6	0.8	-0.7
Depression (Nagel 2018)	0.0	0.0	0.0	0.0	0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.1	-0.0	0.4
Schizophrenia (2018)	0.0	0.1	0.1	-0.3	-0.2
Alzheimer’s Disease (in mother)	0.0	0.0	0.1	-0.1	-0.2
Prostate Cancer	0.0	0.1	0.1	-0.0	-0.4
Neuroticism (2016)	0.0	0.0	0.0	0.1	-0.1
Schizophrenia (2014)	0.0	0.1	0.1	0.1	-0.4
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.0	-0.4
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	-0.1	0.1
Supplements: Zinc	0.0	0.0	0.1	-0.1	0.3
Severe depression (siblings)	0.0	0.0	0.1	0.3	-0.0
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.1	0.3	0.1
Supplements: Glucosamine	0.0	0.0	0.0	0.1	0.2
Waist circumference	0.0	0.1	0.1	-0.2	0.3
Pulse wave Arterial Stiffness index	0.0	0.0	0.1	0.3	-0.1
Arm fat mass (right)	0.0	0.2	0.2	0.3	-0.5
Gout (self-reported)	0.0	0.0	0.0	-0.2	0.2
Medication: Amlodipine	0.0	0.0	0.1	-0.1	-0.3
Worry too long after embarrassment	0.0	0.0	0.0	0.1	0.2
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	0.2	0.1
Whole body fat mass	0.0	0.2	0.2	-0.4	0.4
Chest pain or discomfort	0.0	0.0	0.1	0.2	-0.1
Family relationship satisfaction	0.0	0.1	0.1	0.1	-0.3
Smoking status: Previous	0.0	0.1	0.1	-0.3	-0.2
Arm fat mass (left)	0.0	0.0	0.0	-0.1	-0.0
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.0	-0.2
Risk taking	0.0	0.0	0.0	-0.1	0.1
Fractured/broken bones in last 5 years	0.0	0.0	0.0	0.2	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	0.1	-0.3

Hub : Genes

ROMO1

Models

Trait associations