Hub : Genes

RP11-231C14.6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Coronary 0.166 0.069 0.00640 0.052 NA 0.003 NA 0.030 0.0075 NA 0.2400 NA 0.033
2 GTEx Whole Blood 0.075 0.034 0.00036 -0.003 NA 0.019 NA -0.001 0.9300 NA 0.0069 NA 0.430

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.2 0.3 0.4 -0.3 -0.7
Bipolar Disorder or Schizophrenia 0.0 0.1 0.2 0.4 0.1
Depressed Affect (Nagel 2018) 0.2 0.3 0.5 -0.5 -0.7
Depression (Nagel 2018) 0.0 0.1 0.1 0.1 -0.3
Intelligence (Savage-Jansen 2018) 3.4 10.6 20.9 0.5 4.6
Neuroticism (Nagel 2018) 0.3 0.7 1.2 -1.1 0.5
Schizophrenia (2018) 0.5 1.1 1.7 0.6 1.3
Schizophrenia vs Biploar Disorder 0.0 0.0 0.0 0.0 0.0
Worry (Nagel 2018) 0.3 0.7 1.3 -1.1 0.1
Alzheimer’s Disease (in mother) 1.7 2.0 3.7 1.9 0.6
Alzheimer’s Disease (in father) 0.7 0.7 1.4 -0.2 1.2
Alzheimer’s Disease (including proxy) 1.9 2.7 3.6 1.4 1.9
Crohns Disease (2017) 1.1 2.5 4.6 0.6 -2.1
Irritable Bowel Disease (IBD) 1.8 4.3 8.6 0.1 -2.9
Ulcerative Colitis (UC) 2.0 3.7 6.0 -1.2 -2.5
Major Depression (MDD) 0.3 0.4 0.4 0.6 0.6
Reaction Time 3.0 5.8 8.4 -2.9 1.8
Verbal and Numeric Reasoning (VNR) 2.8 6.7 13.2 0.3 3.6
Breast Cancer 0.6 1.5 2.8 1.7 0.3
Ovarian Cancer 0.7 0.9 1.7 -0.3 1.3
Prostate Cancer 0.2 0.2 0.3 -0.6 -0.4
Age at First Birth 0.3 0.4 0.6 -0.4 -0.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 3.5 4.7 9.1 0.6 -3.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.9 1.4 2.7 1.7 0.0
Mean Putamen Volume 0.2 0.2 0.4 -0.6 0.3
Fasting Glucose 0.6 0.7 1.1 -0.5 1.1
HbA1C 1.2 1.4 2.7 -0.1 -1.6
HDL Cholesterol 1.2 1.9 3.1 1.8 0.9
LDL Cholesterol 1.2 1.9 2.8 -1.7 1.0
Lupus 2.6 3.9 7.2 2.7 0.8
Neuroticism (2016) 1.3 1.8 2.1 -1.2 -1.4
Primary Biliary Cirrhosis 0.8 1.2 1.3 1.2 1.0
Rheumatoid Arthritis 0.3 0.5 1.0 1.0 0.0
Schizophrenia (2014) 0.1 0.1 0.2 -0.4 0.3
Triglycerides 0.8 1.3 1.7 -0.9 -1.3
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.1 0.2 0.4 0.1 -0.6
Blood Eosinophil Count 0.0 0.0 0.0 -0.0 0.2
Blood Platelet Count 4.1 47.6 95.3 -9.8 -0.1
Blood Red Count 0.5 5.3 10.5 0.3 3.2
Blood White Count 0.8 6.2 6.9 -2.6 -2.3
Heel T-Score 0.4 3.3 4.0 -1.6 2.0
BMI 6.0 34.8 57.2 3.5 -7.6
Height 1.1 20.7 21.4 4.5 -4.6
Waist Hip Ratio (WHR) 1.1 5.1 6.9 1.8 -2.6
Systolic Blood Pressure 0.7 3.4 4.5 1.6 -2.1
Smoking Status 0.4 1.0 1.7 1.3 -0.6
Allergy or Eczema 6.9 18.1 18.7 -4.3 4.2
Cardiovascular Disease 1.0 3.4 4.5 1.6 -2.1
Hypothyroidism (self reported) 1.3 3.1 5.7 0.7 -2.4
Respiratory disease 1.8 4.0 6.4 -2.5 1.2
Type 2 Diabetes (T2D) (2018) 0.3 0.5 0.9 -0.2 -1.0
Lung FEV1/FVC ratio 0.1 0.4 0.8 0.1 0.9
Lung FVC 1.2 6.1 6.9 2.6 2.3
Neuroticism 0.5 1.2 2.0 -1.4 0.6
Chronotype (morning person) 0.1 0.3 0.6 -0.8 -0.3
Hair Pigment 0.2 5.5 7.5 -2.7 1.9
Tanning 0.2 2.1 3.3 1.0 1.8
Hand grip strength (left) 0.4 1.0 1.9 1.4 -0.2
Number of treatments/medications taken 0.2 0.3 0.6 -0.2 -0.8
Average weekly spirits intake 0.0 0.0 0.0 -0.1 0.1
Sensitivity / hurt feelings 0.0 0.0 0.1 0.2 -0.1
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.5 -0.7 0.1
Hearing difficulty/problems: Yes 0.0 0.0 0.0 -0.1 0.2
Relative age of first facial hair 0.1 0.3 0.5 -0.7 0.3
Other serious medical condition/disability diagnosed by doctor 0.0 0.0 0.0 0.2 -0.1
Ever used hormone-replacement therapy (HRT) 0.8 1.1 1.9 -0.5 1.4
Ever had hysterectomy (womb removed) 2.2 2.5 4.3 -2.1 -0.8
Systolic blood pressure, automated reading 0.4 1.0 1.4 1.2 -0.8
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.3 -0.4 0.5
Angina 0.4 0.5 0.9 -1.0 -0.2
Medication for hormone replacement therapy 4.4 4.9 7.6 -1.5 2.8
Vitamin and mineral supplements 0.3 0.4 0.8 -0.9 -0.2
Supplements: Zinc 0.4 0.5 1.0 -1.0 -0.1
Medication: Co-codamol 1.5 1.7 3.4 -0.3 -1.8
Medication: Metformin 0.2 0.3 0.5 0.1 -0.7
Diabetes (father) 0.8 1.0 1.1 -1.0 -1.0
Diabetes (mother) 0.5 0.6 1.1 0.2 -1.1
Severe depression (siblings) 0.3 0.4 0.7 0.2 0.8
Pack years adult smoking proportion 4.7 7.2 14.0 -0.6 -3.7
Impedance of leg (right) 1.5 7.4 10.0 -2.2 3.2
Leg fat-free mass (left) 4.4 23.6 35.2 3.5 -5.9
Trunk fat percentage 9.2 37.1 58.8 3.9 -7.7
Hand grip strength (right) 0.1 0.4 0.8 -0.0 0.9
Townsend deprivation index at recruitment 1.3 1.8 3.6 0.4 -1.9
Current tobacco smoking 0.9 1.5 2.7 -0.6 -1.6
Average weekly fortified wine intake 0.5 0.6 1.2 -0.1 1.1
Maternal smoking around birth 1.1 1.6 1.8 -1.2 1.3
Fed-up feelings 0.2 0.3 0.6 -0.8 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 1.0 1.0 -0.5
Relative age voice broke 0.5 0.7 1.1 -0.6 1.0
Taking other prescription medications 0.2 0.2 0.4 -0.7 0.2
Age when periods started (menarche) 3.3 7.9 14.3 -1.2 3.8
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.4 -0.6 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.4 -0.1 0.6
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 2.1 -1.5 -0.5
Qualifications: CSEs or equivalent 0.0 0.0 0.1 -0.3 -0.2
Serious illness, injury or assault to yourself 0.1 0.1 0.3 -0.1 0.5
High blood pressure 2.1 6.0 6.2 2.4 -2.5
Hayfever, allergic rhinitis or eczema 5.4 11.8 12.3 -3.5 3.4
Multivitamins +/- minerals 0.4 0.5 1.1 0.1 1.0
Stomach or abdominal pain in last month 0.1 0.1 0.2 -0.2 -0.4
Supplements: Glucosamine 0.7 1.0 1.8 -0.3 1.3
Diverticular disease/diverticulitis (self-reported) 0.2 0.3 0.4 -0.7 0.4
Medication: Atenolol 0.8 1.0 1.7 0.4 -1.3
Medication: Levothyroxine sodium 0.4 0.7 1.5 -0.0 -1.2
Sitting height 0.7 4.7 7.8 2.8 -1.3
Chronic bronchitis/emphysema (father) 0.8 1.0 1.6 -0.5 1.3
High blood pressure (mother) 1.6 2.2 2.6 -1.6 -1.4
Body mass index (BMI) 5.2 22.3 35.0 3.1 -5.9
Impedance of leg (left) 1.1 5.3 7.8 -1.7 2.8
Leg predicted mass (left) 4.5 23.9 35.8 3.5 -6.0
Trunk fat mass 10.0 43.0 65.9 4.5 -8.1
Waist circumference 10.7 39.1 62.7 3.9 -7.9
Number of incorrect matches in round 0.5 0.8 1.6 0.2 1.3
Past tobacco smoking 0.3 0.5 0.7 -0.8 -0.6
Alcohol usually taken with meals 3.3 5.3 10.2 -0.6 3.2
Nervous feelings 1.6 3.1 6.1 -2.5 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.6 3.2 -1.8 0.3
Hearing difficulty/problems with background noise 0.3 0.4 0.8 -0.1 0.9
Hair/balding pattern: Pattern 2 0.1 0.1 0.1 -0.4 -0.0
Had menopause 0.1 0.1 0.2 -0.0 -0.4
Had other major operations 0.4 0.5 0.6 -0.8 -0.6
Forced vital capacity (FVC) 1.6 6.0 11.6 3.4 0.7
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 4.0 -0.7 2.0
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.0 0.1 -0.1
Qualifications: None of the above 2.1 4.4 8.2 0.8 -2.9
Financial difficulties in last 2 years 0.4 0.5 0.9 0.9 0.3
Mouth/teeth dental problems 0.9 1.4 2.2 -1.5 0.7
Heart attack 0.9 1.1 1.6 1.3 -0.8
Allergy 4.3 10.0 10.4 3.1 -3.2
Pain all over the body in last month 1.5 1.6 3.3 1.8 -0.1
Diabetes (self-reported) 0.5 0.8 1.6 0.1 -1.3
Hayfever/allergic rhinitis (self-reported) 7.4 9.8 9.9 -3.1 3.1
Medication: Ramipril 5.0 6.5 12.0 1.0 -3.5
Medication: Simvastatin 0.2 0.3 0.5 0.1 -0.7
Fluid intelligence score 1.8 3.7 7.0 0.6 2.6
Illnesses of siblings 0.1 0.1 0.1 -0.2 0.3
Neuroticism score 0.2 0.3 0.6 -0.8 0.1
Weight 7.5 36.6 53.6 4.4 -7.3
Impedance of arm (right) 0.2 1.1 2.2 0.0 -1.5
Arm fat percentage (right) 9.3 36.7 56.1 4.2 -7.5
Trunk fat-free mass 1.8 10.3 13.0 2.8 -3.6
Hip circumference 8.8 37.9 60.7 3.9 -7.8
Time employed in main current job 0.4 0.5 0.8 -0.5 0.9
Alcohol intake versus 10 years previously 0.8 1.2 2.3 0.3 -1.5
Father’s age at death 0.2 0.3 0.6 -0.8 0.1
Worrier / anxious feelings 0.3 0.6 1.3 -1.1 -0.0
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 1.9 0.6 -1.4
Falls in the last year 0.0 0.1 0.1 0.2 -0.3
Hair/balding pattern: Pattern 3 0.5 0.7 1.2 0.5 1.1
Number of live births 6.7 9.5 13.9 -3.7 2.3
Forced expiratory volume in 1-second (FEV1) 1.8 6.0 10.2 3.2 1.3
Pulse rate 2.5 4.1 8.1 -2.8 0.5
Happiness 0.7 0.8 1.7 0.0 1.3
Noisy workplace 0.0 0.0 0.0 0.2 -0.1
Qualifications: A levels/AS levels or equivalent 0.3 0.7 1.3 0.2 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 -0.2 0.6
Mouth/teeth dental problems: Dentures 1.4 2.4 4.3 2.1 -0.7
Asthma 1.8 3.5 3.5 -1.9 1.8
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 3.5 -1.9 -0.3
Medication: Cholesterol lowering 0.3 0.4 0.4 0.6 0.7
Depression (self-reported) 0.6 0.7 1.5 0.1 1.2
Medication: Lansoprazole 0.1 0.1 0.1 -0.0 -0.4
Prospective memory result 0.6 0.7 1.4 1.2 0.0
Lung cancer (father) 1.6 1.9 3.7 1.9 -0.4
Illnesses of mother 0.3 0.4 0.5 0.7 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.1 7.5 2.7 0.8
Pulse wave Arterial Stiffness index 0.3 0.4 0.8 -0.9 0.0
Impedance of arm (left) 0.1 0.6 1.2 -0.1 -1.1
Arm fat mass (right) 8.8 36.1 56.6 4.0 -7.5
Trunk predicted mass 1.8 10.0 12.7 2.7 -3.6
Standing height 1.3 12.5 14.0 3.3 -3.7
Length of working week for main job 0.0 0.0 0.0 0.2 -0.2
Exposure to tobacco smoke at home 1.1 1.2 2.3 -1.5 0.4
Breastfed as a baby 1.3 1.7 3.3 -0.0 1.8
Tense / ‘highly strung’ 0.7 1.2 1.6 1.2 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 1.3 0.0 -1.2
Hair/balding pattern: Pattern 4 0.6 1.4 2.4 -1.5 0.6
Birth weight of first child 0.5 0.8 0.9 0.9 -0.9
Peak expiratory flow (PEF) 2.4 5.5 9.1 3.0 1.4
Pulse wave reflection index 0.5 0.7 1.3 -0.2 1.1
Ever highly irritable/argumentative for 2 days 2.9 3.5 4.8 1.5 -2.2
Loud music exposure frequency 1.8 2.0 3.9 2.0 0.4
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 1.3 -0.4 1.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 0.6 0.8 -0.8
Blood clot in the leg (DVT) 1.4 1.9 2.6 -1.6 1.1
Medication: Paracetamol 0.7 1.2 2.1 -0.6 -1.4
Headache pain in last month 0.0 0.0 0.0 0.2 0.2
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.2 -0.4 0.1
Glaucoma (self-reported) 1.6 1.9 1.9 -1.4 1.4
Gout (self-reported) 1.3 1.8 2.1 1.4 1.2
Hypothyroidism/myxoedema (self-reported) 0.2 0.3 0.7 0.2 -0.8
Medication: Amlodipine 1.1 1.6 2.8 1.7 -0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.2 -0.1 0.4
Birth weight 0.5 1.1 2.0 0.4 -1.4
Chronic bronchitis/emphysema (mother) 0.5 0.6 0.9 -0.5 -1.0
High blood pressure (siblings) 0.5 0.7 1.0 -1.0 0.7
Forced vital capacity (FVC), Best measure 1.1 3.9 7.8 2.8 -0.1
Body fat percentage 8.2 32.6 51.0 3.8 -7.1
Leg fat percentage (right) 4.4 15.9 25.9 2.4 -5.1
Arm fat-free mass (right) 2.4 12.0 15.9 2.9 -4.0
Exposure to tobacco smoke outside home 2.0 2.7 4.4 2.1 -1.0
Comparative body size at age 10 2.2 6.1 9.9 1.5 -3.1
Number of full brothers 0.3 0.4 0.6 -0.8 -0.4
Worry too long after embarrassment 2.7 4.6 8.4 -2.9 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 -0.0 0.1
Wheeze or whistling in the chest in last year 1.2 2.2 3.7 -0.8 -1.9
Number of children fathered 4.3 4.8 5.2 -2.1 2.3
Reason for reducing amount of alcohol drunk: Health precaution 1.4 1.6 2.6 -0.8 1.6
Age at first live birth 0.6 1.0 2.1 1.4 -0.0
Pulse wave peak to peak time 0.6 0.7 1.3 1.1 -0.2
Health satisfaction 0.8 1.1 1.4 0.9 -1.2
Shortness of breath walking on level ground 0.5 0.6 1.3 0.0 -1.1
Qualifications: College or University degree 4.3 13.5 23.6 -1.8 4.9
Eye problems/disorders: None of the above 2.7 3.2 5.8 0.7 -2.4
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.3 -0.8 -1.1
Emphysema/chronic bronchitis 0.4 0.5 1.0 1.0 -0.0
Medication for pain relief, constipation, heartburn 1.2 2.1 4.1 0.2 2.0
Neck or shoulder pain in last month 0.1 0.1 0.2 0.2 0.4
Medication: Blood pressure 1.0 1.7 2.2 1.1 -1.5
Angina (self-reported) 0.4 0.5 1.0 -1.0 -0.3
Migraine (self-reported) 0.6 0.7 1.3 -0.4 1.1
Medication: Ibuprofen 1.4 1.7 2.8 -1.7 -0.8
Medication: Allopurinol 0.6 0.8 1.5 0.2 1.2
Medication: Omeprazole 0.2 0.2 0.5 0.7 -0.0
Medication: Seretide 50 evohaler 0.3 0.3 0.7 -0.0 0.8
Mean time to correctly identify matches 3.4 6.4 11.0 -3.3 1.4
Heart disease (mother) 2.7 3.3 6.5 -2.5 -0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 4.7 -0.8 -2.2
Whole body fat mass 8.6 36.0 56.0 4.0 -7.5
Leg fat mass (right) 6.4 24.9 39.2 3.3 -6.3
Arm predicted mass (right) 2.2 11.4 14.8 2.8 -3.9
Pulse rate, automated reading 1.8 5.9 10.5 -3.2 -1.1
Alcohol intake frequency. 7.2 16.8 28.8 2.2 -5.4
Comparative height size at age 10 1.7 9.4 10.4 2.9 -3.2
Number of full sisters 0.3 0.3 0.5 0.7 0.4
Suffer from ‘nerves’ 1.6 2.5 4.9 -0.3 -2.2
Overall health rating 0.9 1.9 3.8 -0.0 -2.0
Chest pain or discomfort 0.5 0.7 1.4 -0.2 -1.2
Had major operations 0.1 0.1 0.2 0.2 -0.4
Age at last live birth 0.0 0.0 0.1 -0.1 -0.2
Family relationship satisfaction 1.0 1.2 2.0 1.4 -0.7
Leg pain on walking 0.3 0.4 0.7 -0.9 0.0
Qualifications: NVQ or HND or HNC or equivalent 2.4 2.9 3.0 1.7 -1.7
Commuting to job workplace: Car/motor vehicle 1.2 1.3 2.6 1.6 0.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 0.0 0.5
Medication: Aspirin 0.4 0.5 0.9 0.2 -0.9
Supplements: Vitamin C 0.8 0.9 0.9 0.9 -1.0
Knee pain experienced in last month 0.1 0.2 0.4 -0.6 -0.2
Hypertension (Self-reported) 2.2 6.1 6.6 2.6 -2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.0 -0.1 0.0
Illnesses of father: Heart disease 2.1 2.8 5.6 0.3 -2.4
Illnesses of siblings: Diabetes 2.0 2.5 4.1 1.0 -2.0
Smoking status: Previous 0.4 0.6 1.0 1.0 0.3
Forced expiratory volume in 1-second (FEV1), predicted 1.4 2.9 4.5 1.1 -2.1
Whole body fat-free mass 2.8 15.9 21.7 3.2 -4.7
Leg fat-free mass (right) 4.7 25.1 35.4 3.9 -6.0
Arm fat percentage (left) 8.8 35.1 54.9 3.9 -7.4
Average weekly red wine intake 1.2 1.8 2.5 1.0 1.6
Handedness (chirality/laterality): Left-handed 2.2 2.6 4.4 0.9 -2.1
Mood swings 0.4 0.7 1.1 -1.1 -0.5
Loneliness, isolation 1.8 2.5 4.3 0.8 -2.1
Long-standing illness, disability or infirmity 0.7 1.0 2.0 -0.2 -1.4
Ever had bowel cancer screening 1.1 1.3 2.0 -0.8 1.4
Diabetes diagnosed by doctor 0.3 0.5 0.7 -0.6 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 0.9 0.3 -0.9
Friendships satisfaction 0.6 0.8 1.0 0.7 1.0
Qualifications: nursing, teaching 0.6 1.0 2.0 -0.0 1.4
Commuting to job workplace: Walk 3.0 3.2 6.2 -2.5 0.6
Eye problems/disorders: Cataract 2.6 3.0 6.0 0.1 2.4
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 3.7 0.5 1.9
Medication for cholesterol 0.4 0.6 0.9 0.9 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.2 0.3 0.6 -0.3
Back pain experienced in last month 0.1 0.2 0.3 0.5 0.2
Mineral and other dietary supplements 0.7 0.9 1.1 -1.1 -0.8
Breast cancer (self-reported) 0.2 0.2 0.4 -0.6 0.3
Asthma (self-reported) 1.5 2.9 3.1 -1.6 1.8
Osteoporosis (self-reported) 1.1 1.3 2.2 1.5 0.7
Osteoarthritis (self-reported) 0.5 0.6 0.6 -0.8 -0.8
Medication: Aspirin 0.4 0.5 0.9 0.2 -1.0
Medication: Gliclazide 0.4 0.4 0.8 -0.9 -0.2
Illnesses of father: None of the above (group 1) 2.1 2.6 3.7 1.9 1.3
Smoking status: Current 0.7 1.2 2.3 -0.1 -1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.9 1.9 3.2 0.8 1.8
Whole body water mass 2.7 15.3 20.4 3.2 -4.5
Leg predicted mass (right) 4.7 24.8 34.9 3.8 -5.9
Arm fat mass (left) 8.7 35.5 54.3 4.1 -7.4
Number of self-reported non-cancer illnesses 0.2 0.3 0.6 -0.3 -0.8
Average weekly champagne plus white wine intake 0.3 0.5 0.8 -0.9 0.4
Miserableness 1.5 2.6 4.5 0.8 -2.1
Guilty feelings 0.7 1.1 1.6 -1.2 0.8
Wears glasses or contact lenses 0.8 0.9 1.2 -0.8 -1.1
Ever taken oral contraceptive pill 3.7 4.1 5.9 -2.4 1.5
Hearing aid user 1.0 1.1 2.2 -1.5 -0.0
Mother’s age at death 1.1 1.4 2.8 1.7 0.1
Financial situation satisfaction 0.3 0.4 0.5 -0.6 -0.7
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.2 0.4
Commuting to job workplace: Public transport 0.2 0.2 0.3 -0.3 -0.6
Eye problems/disorders: Glaucoma 3.2 3.8 5.5 -2.3 1.4
Medication: Blood pressure 0.6 1.2 1.9 0.7 -1.4
Pain type(s) experienced in last month: Hip pain 1.1 1.4 2.0 -1.4 -0.9
Supplements: Fish oil (including cod liver oil) 0.5 0.6 0.6 0.8 0.8
High cholesterol (Self-reported) 0.1 0.2 0.4 -0.6 0.1
Medication: Bendroflumethiazide 0.7 1.0 1.1 0.9 -1.1
Medication: Paracetamol 1.0 1.6 3.1 0.2 -1.8
Medication: Lisinopril 0.7 0.9 1.2 1.1 -0.8
Medication: Atorvastatin 2.2 2.7 3.3 -1.4 1.8
Illnesses of father: High blood pressure 1.3 1.6 2.9 -1.7 -0.5
Alcohol drinker status: Never 1.4 1.6 2.1 1.1 -1.5
Ever smoked 0.1 0.1 0.2 -0.2 0.4
Basal metabolic rate 4.0 22.4 30.9 3.7 -5.6
Leg fat percentage (left) 5.1 18.5 29.5 2.8 -5.4
Arm fat-free mass (left) 2.4 12.0 16.6 2.7 -4.1
Number of operations (self-reported) 1.1 1.6 3.2 -1.8 0.2
Average weekly beer plus cider intake 2.4 3.5 6.7 0.6 -2.6
Irritability 0.2 0.3 0.4 0.4 0.7
Risk taking 0.9 1.3 2.0 1.4 0.8
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.5 0.4 0.7
Fractured/broken bones in last 5 years 0.3 0.4 0.8 0.9 0.2
Age started oral contraceptive pill 0.1 0.2 0.2 -0.4 0.5
Diastolic blood pressure, automated reading 1.1 3.5 6.1 0.9 -2.5
Ever depressed for a whole week 0.3 0.4 0.7 0.8 -0.4
Unable to work because of sickness or disability 4.4 5.7 6.8 2.1 -2.6
Commuting to job workplace: Cycle 0.1 0.2 0.3 0.6 -0.0
Myopia 0.2 0.4 0.6 -0.8 -0.3
Vascular/heart problems diagnosed by doctor 2.2 6.1 6.3 -2.5 2.4
Cholesterol lowering medication 1.3 1.9 3.4 -1.8 -0.7
Medication: Omeprazole (e.g. Zanprol) 0.6 0.7 1.3 1.1 -0.4
Pain experienced in last month 0.2 0.3 0.6 -0.1 -0.8
Supplements: Calcium 0.1 0.1 0.2 0.3 -0.4
Basal cell carcinoma (self-reported) 0.0 0.0 0.0 0.1 0.2
Heart attack/myocardial infarction (self-reported) 0.8 1.1 1.3 1.2 -0.9
Deep venous thrombosis (DVT) (self-reported) 0.7 1.0 1.4 -1.2 0.7
Heart disease (siblings) 0.1 0.2 0.3 -0.1 -0.6
Alcohol drinker status: Previous 0.8 1.0 1.5 0.7 -1.2
Pack years of smoking 4.6 6.7 13.3 -0.4 -3.6
Impedance of whole body 0.1 0.6 0.7 -0.8 0.7
Leg fat mass (left) 6.8 26.7 41.1 3.5 -6.4
Arm predicted mass (left) 2.6 13.3 18.2 2.9 -4.3