Hub : Genes

RP11-244O19.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1540	0.0370	2.7e-07	0.073	NA	0.085	NA	0.091	1.4e-06	NA	1.9e-07	NA	7.0e-08
2	GTEx	Adipose Visceral Omentum	0.1790	0.0670	2.1e-03	-0.005	NA	0.005	NA	-0.002	8.5e-01	NA	1.7e-01	NA	4.5e-01
3	GTEx	Adrenal Gland	0.1814	0.0585	6.9e-04	0.290	NA	0.195	NA	0.258	5.8e-11	NA	1.6e-07	NA	8.7e-10
4	GTEx	Artery Tibial	0.0942	0.0355	1.9e-03	0.052	NA	0.013	NA	0.027	6.1e-05	NA	2.9e-02	NA	3.2e-03
5	GTEx	Brain Cerebellar Hemisphere	0.4100	0.1350	7.0e-03	0.169	NA	0.032	NA	0.083	4.2e-05	NA	5.2e-02	NA	3.8e-03
6	GTEx	Brain Cerebellum	0.3450	0.1010	1.6e-03	0.211	NA	0.138	NA	0.153	7.4e-07	NA	7.3e-05	NA	2.8e-05
7	GTEx	Cells Transformed fibroblasts	0.1360	0.0440	4.0e-04	0.074	NA	0.069	NA	0.056	3.3e-06	NA	6.7e-06	NA	4.9e-05
8	GTEx	Lung	0.0907	0.0347	2.1e-03	0.029	NA	0.028	NA	0.043	2.8e-03	NA	3.2e-03	NA	3.1e-04
9	GTEx	Nerve Tibial	0.1140	0.0437	1.8e-03	0.075	NA	0.060	NA	0.074	5.6e-06	NA	4.6e-05	NA	6.6e-06
10	GTEx	Prostate	0.3640	0.1100	3.3e-04	0.090	NA	0.198	NA	0.053	3.0e-03	NA	1.1e-05	NA	1.8e-02
11	GTEx	Spleen	0.3050	0.0930	1.1e-03	0.282	NA	0.129	NA	0.270	6.0e-08	NA	3.4e-04	NA	1.3e-07

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.6	0.9	4.4	0.2	-1.0	0.2	0.0	2.1	1.4	0.1	-0.1	-0.9	-1.2	0.2
Bipolar Disorder or Schizophrenia	0.7	1.7	4.8	1.7	-0.3	1.3	1.3	1.6	0.7	2.2	1.4	-0.1	0.7	1.3
Depressed Affect (Nagel 2018)	0.9	1.8	4.2	-1.6	-0.3	-2.0	-0.9	-1.0	0.1	-1.0	-1.8	-1.6	-0.4	-2.0
Depression (Nagel 2018)	0.6	0.9	2.3	-0.5	1.0	-0.7	-0.7	-1.5	-0.3	-1.5	-1.0	-1.4	-0.1	-0.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	4.3	-1.1	0.3	-0.7	-1.4	0.2	0.4	-0.3	-0.4	-2.1	0.3	-0.7
Neuroticism (Nagel 2018)	0.7	1.7	4.9	-1.3	-0.5	-2.2	-0.2	-0.8	-0.1	0.1	-1.8	-1.6	0.4	-2.2
Schizophrenia (2018)	1.2	2.4	7.8	2.0	0.4	1.6	1.6	0.4	-0.2	2.8	1.9	0.7	1.7	1.5
Schizophrenia vs Biploar Disorder	2.6	3.4	5.9	2.4	0.9	2.0	2.2	-1.7	-1.4	2.1	2.0	1.8	1.0	2.0
Worry (Nagel 2018)	0.3	0.7	1.8	0.1	0.2	-1.1	0.8	0.4	0.5	1.3	-0.5	-1.0	1.0	-1.1
Alzheimer’s Disease (in mother)	1.0	1.1	3.9	-0.5	-1.0	-0.4	-2.0	-1.3	-1.5	-0.5	-0.3	-1.2	-1.0	-0.4
Alzheimer’s Disease (in father)	2.8	3.0	15.9	-1.4	-4.0	-1.7	-1.4	-0.7	-0.6	-0.1	-1.2	-0.7	-2.2	-1.7
Alzheimer’s Disease (including proxy)	2.0	2.9	11.7	-1.1	-3.4	-1.2	-2.3	-1.6	-1.8	0.3	-0.8	-1.6	-1.4	-1.2
Crohns Disease (2017)	0.4	0.8	3.7	0.5	-0.1	-0.2	1.3	-0.6	-0.9	1.2	0.6	0.2	1.9	-0.2
Irritable Bowel Disease (IBD)	0.5	1.2	4.1	0.6	0.4	0.5	1.6	1.2	1.2	1.4	0.9	-0.1	2.0	0.5
Ulcerative Colitis (UC)	0.9	1.7	7.6	0.1	0.7	0.4	1.1	2.6	2.8	0.7	0.2	-0.5	0.9	0.4
Major Depression (MDD)	1.1	1.3	4.9	-1.1	-0.9	-1.6	-0.6	0.1	-0.3	-0.7	-2.2	-0.5	-1.0	-1.6
Reaction Time	1.7	3.2	5.8	1.4	1.5	2.0	1.9	2.4	2.2	1.8	2.2	0.5	-0.7	2.0
Verbal and Numeric Reasoning (VNR)	0.2	0.5	2.8	-1.2	0.2	-0.4	-0.5	0.8	0.6	-0.2	-0.2	-1.7	0.3	-0.4
Breast Cancer	0.6	1.4	3.6	-1.4	-0.8	-1.2	-1.6	0.0	0.1	-1.4	-1.4	-1.9	-0.1	-1.2
Ovarian Cancer	1.5	2.0	5.9	1.9	0.3	1.7	0.8	-0.1	-0.8	1.6	2.4	1.1	0.9	1.7
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	4.2	-0.4	-0.2	-0.2	-0.7	1.0	1.0	-0.6	0.2	-2.0	-0.6	-0.2
Bipolar Disorder (2011)	3.6	3.5	5.6	2.1	0.8	2.4	1.5	2.2	1.8	2.2	1.9	-1.3	1.3	2.4
Body Mass Index (BMI) (2010)	0.4	0.6	1.7	-0.6	-1.3	-0.7	-0.2	0.6	0.4	-0.1	-1.3	-0.9	-0.6	-0.6
Coronary Artery Disease (CAD)	1.0	1.2	4.1	-1.1	-1.0	-0.5	-1.2	1.6	2.0	-0.3	-0.6	-1.4	0.3	-0.5
Crohns Disease (2012)	0.2	0.4	0.8	0.8	-0.3	0.4	0.9	-0.5	-0.5	0.9	0.7	0.1	0.7	0.4
Mean Putamen Volume	0.5	0.5	2.4	-0.4	-0.1	0.0	-0.2	0.6	0.9	-0.3	-0.0	-1.5	1.5	0.0
Fasting Glucose	0.4	0.5	1.4	-0.5	-0.7	0.3	-0.5	1.1	0.9	-0.1	-0.8	-1.2	-0.2	0.3
HbA1C	0.3	0.3	1.5	-0.3	-0.3	0.4	-1.2	0.3	-0.1	-0.7	0.4	-1.0	-0.2	0.4
HDL Cholesterol	1.4	2.4	3.8	-1.6	-0.2	-2.0	-1.7	-1.7	-1.5	-1.5	-1.3	-0.6	-1.8	-2.0
LDL Cholesterol	0.8	1.3	3.1	1.1	0.9	1.4	1.1	0.1	-0.1	1.8	1.3	0.8	1.1	1.4
Lupus	0.3	0.5	1.6	-0.5	-1.0	-0.6	0.3	0.1	0.3	0.0	-1.2	-0.9	1.0	-0.6
Neuroticism (2016)	0.2	0.3	1.2	-0.0	0.6	-0.1	0.5	-1.1	-0.5	0.7	-0.0	0.5	0.5	-0.1
Primary Biliary Cirrhosis	0.6	0.8	3.6	0.7	-1.2	0.3	1.5	0.9	0.4	1.9	-0.0	0.2	-0.5	0.2
Rheumatoid Arthritis	1.8	2.5	4.9	-1.6	-1.6	-0.7	-2.2	-2.2	-2.1	-2.1	-0.8	-0.3	-1.5	-0.6
Schizophrenia (2014)	1.5	3.4	11.0	2.1	0.1	2.0	1.8	0.4	-0.1	3.3	2.3	0.7	2.0	2.0
Triglycerides	0.2	0.3	1.4	-0.1	-0.4	-0.1	0.4	-0.1	-0.2	0.0	-0.3	1.2	-1.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.7	0.7	0.7	1.3	0.1	0.2	0.7	0.5	1.3	-0.4	0.9	1.3
Ulcerative Colitis	1.5	2.1	7.3	0.8	0.0	1.5	1.2	2.7	2.4	1.0	1.0	-0.4	1.1	1.5
Blood Eosinophil Count	0.2	1.7	4.4	-2.1	0.8	-1.0	-1.7	0.0	0.6	-1.4	-1.2	-1.4	-1.9	-1.0
Blood Platelet Count	1.2	14.1	23.3	4.8	3.1	4.4	4.6	0.7	0.3	4.8	4.5	3.8	1.8	4.4
Blood Red Count	0.3	2.9	5.2	-1.8	0.3	-2.2	0.3	2.1	2.3	-0.7	-1.8	0.0	-2.3	-2.2
Blood White Count	0.2	1.6	11.2	0.4	-1.2	0.0	1.9	-0.3	-0.7	-0.0	-0.1	3.3	0.5	0.0
Heel T-Score	0.3	2.0	6.2	-1.6	-2.5	-1.6	0.4	1.5	0.7	0.0	-1.5	1.8	-0.6	-1.6
BMI	0.4	2.2	5.5	-2.0	-1.8	-1.4	-0.1	0.4	0.8	-1.0	-1.5	2.0	-2.3	-1.4
Height	0.4	8.6	32.0	3.0	1.7	3.6	0.6	0.1	-0.1	2.9	3.8	-1.2	5.7	3.6
Waist Hip Ratio (WHR)	0.4	1.6	7.2	-0.5	-0.4	-0.3	0.6	2.3	1.6	1.4	0.3	0.2	2.7	-0.3
Systolic Blood Pressure	0.2	1.0	2.5	0.5	-0.4	0.7	-0.4	-0.7	-1.4	1.6	1.4	1.6	0.0	0.7
Smoking Status	0.5	1.2	3.6	-1.3	-1.4	-1.2	0.1	-0.5	-0.4	-1.1	-1.9	0.9	-0.5	-1.2
Allergy or Eczema	1.0	2.7	10.6	-1.6	0.7	-1.4	-0.3	2.7	3.3	-0.1	-1.1	-0.1	-1.8	-1.4
Cardiovascular Disease	0.1	0.2	0.6	-0.6	0.6	-0.1	-0.7	0.8	0.2	0.3	-0.1	0.4	0.7	-0.1
Hypothyroidism (self reported)	1.1	2.5	4.9	-1.8	-1.2	-1.8	-1.6	-0.4	-0.1	-2.1	-1.4	-1.6	-2.2	-1.8
Respiratory disease	0.7	1.6	4.8	-1.3	0.1	-1.0	0.0	1.8	2.2	-0.2	-1.2	0.3	-2.0	-1.0
Type 2 Diabetes (T2D) (2018)	0.6	1.0	3.2	-0.6	-1.0	-0.7	0.1	1.7	1.8	0.3	-0.4	-0.9	1.3	-0.7
Lung FEV1/FVC ratio	0.6	3.3	7.4	2.5	1.9	2.6	0.6	0.3	0.2	1.8	2.7	-0.4	1.1	2.6
Lung FVC	0.9	4.4	12.0	-2.3	-1.6	-2.1	-2.8	1.0	0.2	-1.7	-2.1	-3.5	-1.8	-2.1
Neuroticism	0.6	1.5	3.8	-0.6	1.0	-1.4	1.2	1.1	2.0	1.3	-1.2	-0.9	0.7	-1.4
Chronotype (morning person)	1.1	2.4	6.2	-2.0	0.3	-1.8	-1.6	-0.8	-0.7	-1.9	-1.8	-0.1	-2.5	-1.8
Hair Pigment	0.0	1.0	3.5	0.9	1.2	1.4	0.6	-0.3	0.2	-0.7	1.9	-0.1	-0.9	1.4
Tanning	0.1	0.7	2.6	-0.4	0.0	-0.6	-1.0	-1.6	-1.6	-0.2	-0.5	-0.0	0.4	-0.6
Hand grip strength (left)	1.1	2.9	12.7	1.5	0.5	1.7	-0.9	-2.8	-3.6	0.5	1.4	0.7	0.3	1.7
Number of treatments/medications taken	0.9	1.6	7.1	0.1	0.0	0.5	1.7	1.6	1.1	1.3	0.5	2.7	1.4	0.5
Average weekly spirits intake	1.3	1.6	5.5	1.8	1.0	1.4	1.1	-0.7	-0.1	1.3	0.5	0.1	2.3	1.4
Sensitivity / hurt feelings	0.4	0.7	1.5	-0.8	-0.8	-1.2	0.1	-0.4	0.8	-0.5	-1.2	-0.5	0.7	-1.2
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.2	-0.1	1.3	-0.2	0.0	-1.5	-0.6	-1.8	-0.7	0.3	-0.5	-0.2
Hearing difficulty/problems: Yes	1.3	2.0	7.4	-1.7	-2.7	-1.9	-0.5	0.0	0.4	0.0	-1.0	-0.5	1.8	-1.9
Relative age of first facial hair	0.2	0.5	1.3	-0.0	0.6	0.0	-1.1	-1.1	-1.1	-1.0	0.4	0.4	0.3	0.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	4.0	-1.0	-1.5	-0.5	-1.0	0.0	0.1	-2.0	-0.8	-0.2	-1.8	-0.5
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.2	0.7	0.5	0.1	0.3	0.8	-0.7	0.4	0.4	0.6	0.5
Ever had hysterectomy (womb removed)	1.4	1.5	2.4	1.3	1.2	1.4	1.5	1.1	1.2	1.0	1.0	0.9	1.5	1.4
Systolic blood pressure, automated reading	0.3	1.0	2.7	-0.8	-1.6	-0.6	-0.9	-1.1	-1.6	1.3	-0.1	0.4	-0.5	-0.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	5.9	-1.4	0.4	-0.8	-0.9	-0.5	-0.4	-2.4	-0.9	0.4	-0.9	-0.8
Angina	0.5	0.7	3.8	0.1	-0.4	0.5	0.7	0.4	0.2	0.3	0.2	2.0	-1.6	0.5
Medication for hormone replacement therapy	1.0	1.1	2.6	-1.6	1.2	-1.5	-0.5	-0.1	-0.1	-0.7	-1.5	0.5	0.2	-1.5
Vitamin and mineral supplements	0.6	0.9	4.2	0.3	0.7	0.4	-0.1	-2.0	-1.5	-0.4	0.5	0.6	1.2	0.4
Supplements: Zinc	0.9	1.0	4.2	-0.1	-1.4	-0.2	-0.6	-0.7	-1.8	0.3	-0.5	0.4	-2.1	-0.2
Medication: Co-codamol	1.8	2.1	4.3	1.2	-0.4	1.0	2.0	1.6	1.6	2.1	1.3	1.4	1.5	1.0
Medication: Metformin	0.8	1.1	3.5	-1.1	-1.9	-1.4	-0.2	0.9	0.8	-0.4	-1.3	0.1	-0.2	-1.4
Diabetes (father)	0.2	0.2	0.8	-0.3	0.3	-0.4	0.5	0.7	0.9	0.4	0.3	0.4	-0.6	-0.4
Diabetes (mother)	0.3	0.4	0.9	0.3	0.6	0.8	-0.3	0.3	-0.6	0.1	0.9	-0.6	1.0	0.8
Severe depression (siblings)	0.8	0.9	4.2	1.2	0.4	0.3	0.9	0.2	-0.0	2.0	0.3	0.0	1.8	0.3
Pack years adult smoking proportion	1.2	1.9	5.8	-1.8	-1.1	-1.2	-0.9	-0.9	0.2	-2.4	-2.0	0.6	-1.1	-1.2
Impedance of leg (right)	0.3	1.3	3.7	1.0	1.6	0.6	1.9	1.2	1.4	1.4	0.4	0.4	-0.5	0.6
Leg fat-free mass (left)	0.2	1.0	6.4	0.3	-0.3	0.8	0.6	0.1	0.3	1.2	0.9	0.6	2.5	0.9
Trunk fat percentage	0.4	1.7	9.7	0.2	-1.2	0.5	2.1	0.8	1.1	0.5	0.0	3.1	-0.7	0.5
Hand grip strength (right)	1.0	2.6	11.8	1.4	0.2	1.5	-0.7	-2.6	-3.4	0.8	1.3	0.8	0.2	1.5
Townsend deprivation index at recruitment	0.8	1.1	2.3	1.1	-0.3	1.2	1.5	1.0	1.2	0.1	1.3	1.4	0.4	1.2
Current tobacco smoking	1.1	1.8	7.1	-0.7	-0.7	-0.6	0.3	-1.8	-1.8	-1.1	-1.1	2.7	-1.3	-0.6
Average weekly fortified wine intake	0.7	0.8	2.9	0.1	0.1	-0.8	0.5	1.3	1.3	-0.4	-0.4	-1.7	0.7	-0.8
Maternal smoking around birth	0.8	1.1	3.6	1.2	-0.4	0.6	0.3	-1.5	-1.6	-0.1	0.7	1.0	1.9	0.6
Fed-up feelings	0.1	0.2	0.6	-0.2	0.5	-0.7	0.4	-0.8	0.1	-0.3	-0.5	0.3	0.0	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	4.9	1.0	-0.1	0.9	0.0	-2.2	-1.4	-0.7	0.4	0.2	0.7	0.9
Relative age voice broke	1.0	1.5	5.7	0.9	2.4	1.0	0.4	-0.3	-0.5	0.6	1.3	0.7	2.2	1.0
Taking other prescription medications	0.2	0.3	1.2	-0.4	0.3	0.0	0.0	0.8	1.1	-0.2	0.5	1.0	0.1	0.0
Age when periods started (menarche)	0.4	0.9	4.8	-0.3	2.2	0.4	0.4	-0.7	-0.7	0.5	0.8	1.6	0.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	2.6	-0.4	-0.6	0.2	-0.2	0.5	0.5	-1.6	-0.5	0.1	-0.6	0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	5.0	-2.0	-1.3	-2.2	-1.4	-0.2	-0.6	-1.0	-1.5	0.4	-0.8	-2.2
Tinnitus: Yes, but not now, but have in the past	2.8	3.0	5.0	-2.2	-1.5	-1.9	-2.2	0.4	0.3	-1.6	-2.0	-2.0	-1.4	-1.9
Qualifications: CSEs or equivalent	0.5	0.6	2.3	0.1	0.5	0.5	0.6	-1.5	-1.0	0.6	0.7	1.1	0.3	0.5
Serious illness, injury or assault to yourself	0.7	0.9	4.2	-0.3	-0.3	-0.5	0.6	1.1	1.4	-0.2	-1.0	0.4	-2.0	-0.5
High blood pressure	0.2	0.4	1.7	-0.5	0.3	-0.5	-0.1	0.3	-0.0	0.5	-0.6	1.3	1.1	-0.5
Hayfever, allergic rhinitis or eczema	0.8	1.8	6.5	-1.0	0.8	-1.0	-0.1	2.2	2.5	0.3	-0.8	-0.0	-2.2	-1.0
Multivitamins +/- minerals	0.6	0.8	5.7	-0.1	-0.1	-0.6	-0.3	0.6	-0.0	-0.8	-1.0	0.4	-2.4	-0.6
Stomach or abdominal pain in last month	0.5	0.6	2.3	0.1	-0.4	-0.2	1.1	1.5	1.3	0.4	-0.7	-0.2	-0.6	-0.2
Supplements: Glucosamine	1.3	1.7	6.1	-1.9	-0.6	-1.2	-1.9	0.7	0.4	0.4	-1.0	-2.5	1.0	-1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	5.0	-0.4	-1.8	0.1	-0.5	-1.8	-2.1	-1.1	-0.7	1.8	-2.2	0.1
Medication: Atenolol	1.1	1.4	4.8	-1.4	-0.6	-1.0	-2.2	-1.1	-1.4	-0.9	-0.6	-0.7	1.2	-1.0
Medication: Levothyroxine sodium	1.0	1.7	4.0	-1.6	-0.7	-1.6	-1.2	-0.2	0.1	-2.0	-1.5	-1.2	-1.0	-1.6
Sitting height	0.3	1.9	9.9	0.9	1.5	1.2	-0.3	-0.3	-0.3	1.0	1.3	-1.7	3.1	1.2
Chronic bronchitis/emphysema (father)	1.1	1.3	3.8	1.2	0.4	1.5	1.3	-0.8	-0.7	-0.1	1.0	1.9	-0.2	1.5
High blood pressure (mother)	1.4	2.0	4.2	-2.0	-1.3	-1.9	-1.3	-0.1	0.2	-0.8	-1.6	-1.8	-0.9	-1.9
Body mass index (BMI)	0.4	1.8	9.7	-1.1	-1.8	-0.7	0.7	-0.2	0.2	-1.0	-0.9	3.1	-1.6	-0.7
Impedance of leg (left)	0.2	1.2	3.3	1.1	1.6	0.7	1.8	1.0	1.2	1.1	0.6	0.5	-0.7	0.7
Leg predicted mass (left)	0.2	0.9	6.2	0.2	-0.3	0.8	0.5	0.1	0.3	1.2	0.8	0.6	2.5	0.8
Trunk fat mass	0.3	1.4	8.2	-0.0	-1.2	0.5	1.8	0.7	1.1	0.7	0.1	2.9	-0.1	0.5
Waist circumference	0.4	1.6	8.3	-0.6	-1.1	0.0	1.7	1.3	1.6	0.5	0.1	2.9	0.2	0.1
Number of incorrect matches in round	0.3	0.6	1.3	1.1	-0.7	0.5	1.0	0.7	0.8	0.4	0.3	0.6	-1.1	0.5
Past tobacco smoking	0.2	0.3	1.0	0.8	0.2	0.5	0.7	-0.3	-0.3	0.5	1.0	0.4	0.4	0.5
Alcohol usually taken with meals	3.0	4.8	21.2	-2.1	-1.5	-2.1	-2.9	-0.1	-0.2	-1.3	-2.0	-4.6	-1.2	-2.1
Nervous feelings	0.6	1.1	3.5	1.4	-0.2	0.8	1.8	0.0	0.2	1.9	1.0	1.0	0.4	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	-0.1	1.0	-0.3	0.1	-0.0	0.2	0.5	-0.5	-1.1	0.1	-0.3
Hearing difficulty/problems with background noise	0.7	1.0	3.9	-1.1	-2.0	-1.3	-1.0	0.2	0.1	-0.1	-0.9	-0.8	0.6	-1.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.8	-0.3	1.2	0.5	-0.3	-0.1	-0.1	-1.3	-0.0	-0.7	-0.3	0.5
Had menopause	4.1	5.1	11.3	-3.2	-0.9	-2.4	-3.4	-0.1	0.6	-3.2	-2.2	-2.2	-1.5	-2.4
Had other major operations	0.6	0.7	3.7	-0.5	0.3	-0.8	0.5	-0.6	-0.3	-0.4	-0.8	1.9	-0.9	-0.8
Forced vital capacity (FVC)	0.2	0.7	4.2	-0.1	-0.8	-0.0	-0.9	0.9	0.2	1.1	0.3	-2.1	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	7.6	-2.4	-2.5	-2.8	-1.5	-0.1	-0.7	-1.4	-2.3	0.4	-1.8	-2.8
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.5	0.9	0.3	0.1	0.5	-0.5	-0.6	-0.6	-0.3	1.6	0.3	0.1
Qualifications: None of the above	0.6	1.3	7.8	0.6	-0.7	0.3	1.7	0.0	0.3	0.8	0.2	2.8	1.2	0.3
Financial difficulties in last 2 years	1.2	1.6	6.9	-0.5	-2.6	-1.0	0.5	-0.9	-1.0	-0.3	-1.3	1.7	-1.4	-1.0
Mouth/teeth dental problems	1.7	2.6	6.6	1.8	0.8	2.6	1.2	0.9	0.2	1.8	2.4	0.3	0.8	2.6
Heart attack	0.5	0.6	2.1	0.2	-0.6	0.5	0.1	1.4	0.8	-0.7	-0.9	0.7	-1.2	0.5
Allergy	0.6	1.3	4.2	1.0	-0.9	0.9	0.1	-1.7	-2.0	-0.1	0.7	-0.1	1.6	0.9
Pain all over the body in last month	0.9	1.0	2.6	1.2	1.0	1.1	1.2	-0.3	-0.0	0.1	1.6	0.8	-0.9	1.1
Diabetes (self-reported)	0.4	0.7	2.9	-0.3	-0.5	-0.3	0.3	1.7	1.5	-0.2	-0.3	0.7	1.1	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	1.0	2.7	-1.1	-0.6	-1.6	-0.1	0.9	1.2	0.3	-1.1	-0.2	-0.5	-1.6
Medication: Ramipril	0.5	0.7	1.8	-1.1	-1.4	-0.4	0.2	1.2	0.7	1.1	-0.1	0.9	0.1	-0.4
Medication: Simvastatin	0.3	0.4	1.3	-0.2	-1.1	0.7	0.1	0.2	-0.6	-0.7	0.5	0.9	0.4	0.7
Fluid intelligence score	0.7	1.4	4.1	-1.8	-0.4	-1.4	-1.4	0.4	0.2	-0.4	-1.3	-2.0	-0.3	-1.4
Illnesses of siblings	3.4	4.8	8.8	2.8	3.0	2.8	1.9	-1.0	-1.3	2.4	2.4	0.7	1.6	2.8
Neuroticism score	0.3	0.6	2.7	0.5	0.3	-0.4	1.6	0.0	0.7	1.4	-0.5	0.2	0.7	-0.5
Weight	0.2	0.7	4.9	-0.6	-1.2	0.1	0.8	0.2	0.7	0.1	-0.0	2.2	0.5	0.2
Impedance of arm (right)	0.6	2.7	5.4	2.2	1.3	1.3	2.3	2.0	1.9	2.1	0.9	-1.2	0.1	1.3
Arm fat percentage (right)	0.5	1.9	8.4	-0.4	-1.9	-0.3	1.7	0.7	1.0	-0.1	-0.8	2.9	-1.9	-0.3
Trunk fat-free mass	0.1	0.9	7.3	-0.7	-0.2	0.2	-0.9	-0.4	-0.3	0.4	0.5	0.2	2.7	0.2
Hip circumference	0.3	1.4	8.6	-0.1	-0.6	0.2	1.9	0.5	1.2	0.3	-0.0	2.9	-1.1	0.2
Time employed in main current job	0.1	0.1	0.6	-0.1	-0.1	0.3	-0.4	-0.3	-0.6	0.2	0.1	-0.3	0.8	0.3
Alcohol intake versus 10 years previously	0.2	0.4	1.6	-0.7	-0.0	0.1	-0.5	-0.6	-0.6	-1.0	0.3	1.3	-0.2	0.1
Father’s age at death	1.1	1.5	5.5	-0.3	-0.2	-0.8	0.6	2.1	2.4	1.4	-0.2	-1.4	0.6	-0.8
Worrier / anxious feelings	0.3	0.5	2.4	0.1	0.6	-0.3	0.2	-0.1	0.2	0.9	-0.2	-1.4	1.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.6	0.9	3.6	-0.5	-1.9	-1.0	0.5	-0.8	-0.3	-1.3	-1.1	0.6	-0.7	-1.0
Falls in the last year	0.3	0.4	1.0	-0.5	-0.3	-0.7	0.7	0.4	1.0	0.6	-0.6	-0.4	0.7	-0.7
Hair/balding pattern: Pattern 3	0.5	0.7	2.9	-0.4	-1.7	-1.0	-0.9	-0.8	-0.7	-0.4	-0.6	0.4	-0.4	-1.0
Number of live births	0.9	1.2	5.8	-0.2	-2.4	-0.9	0.6	-1.4	-0.9	-0.6	-1.4	0.3	0.3	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.6	0.3	-0.6	0.2	-0.3	1.6	1.1	1.5	0.6	-2.1	-0.2	0.2
Pulse rate	0.9	1.5	3.8	1.9	0.2	1.9	1.0	-0.6	-0.7	-0.1	1.5	1.0	0.2	1.9
Happiness	0.7	0.8	2.3	-0.4	-0.4	-1.1	-1.2	-0.4	-0.2	-1.2	-1.5	-1.0	-0.6	-1.1
Noisy workplace	0.5	0.6	1.8	0.0	-0.1	-0.4	1.1	1.2	1.3	-0.5	-0.4	1.1	-0.0	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	6.9	-0.1	-0.1	-0.4	-0.6	1.3	1.3	0.1	0.2	-2.6	-0.4	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	3.9	0.5	-0.4	0.6	-1.0	-1.6	-2.0	0.0	0.5	0.1	0.1	0.6
Mouth/teeth dental problems: Dentures	1.1	1.9	3.5	-1.7	-0.5	-1.5	-1.6	-1.8	-1.1	-1.9	-1.7	0.0	-0.0	-1.5
Asthma	0.3	0.7	4.1	-0.4	-0.9	-0.5	0.1	0.8	1.0	0.2	0.0	0.3	-2.0	-0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.2	0.4	-0.2	0.5	-0.1	-0.3	-0.4	-0.1	0.2	0.2	0.4	0.5
Medication: Cholesterol lowering	0.4	0.6	2.0	0.3	0.5	1.4	0.3	0.4	-0.3	-0.7	1.1	0.5	0.4	1.4
Depression (self-reported)	0.7	0.9	1.7	1.1	0.7	1.3	0.6	0.4	0.2	1.2	1.0	-0.0	1.1	1.3
Medication: Lansoprazole	1.1	1.2	3.4	-1.2	-1.8	-1.5	-0.3	-0.1	-0.3	0.0	-1.5	-0.7	-0.8	-1.5
Prospective memory result	0.7	0.8	1.7	1.2	0.3	0.8	0.9	-1.3	-1.0	0.9	0.9	1.2	0.5	0.8
Lung cancer (father)	0.4	0.4	1.7	0.1	-0.4	0.1	-0.5	-1.1	-1.3	-0.1	0.1	0.7	1.1	0.1
Illnesses of mother	4.1	5.0	9.2	2.6	2.7	2.5	3.0	0.7	0.4	1.8	2.1	3.0	1.4	2.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	4.1	0.4	-0.3	0.4	-0.2	1.2	0.7	1.2	0.6	-2.0	-0.0	0.4
Pulse wave Arterial Stiffness index	1.7	2.0	7.7	-0.5	0.9	0.0	0.9	2.8	2.6	1.2	0.1	1.8	1.1	0.0
Impedance of arm (left)	0.3	1.2	2.7	1.2	0.5	0.5	1.4	1.6	1.6	1.2	0.1	-1.4	-0.3	0.5
Arm fat mass (right)	0.3	1.4	8.9	-0.6	-1.7	-0.3	1.2	0.1	0.6	-0.2	-0.6	3.0	-1.0	-0.3
Trunk predicted mass	0.1	0.8	6.9	-0.8	-0.3	0.1	-1.0	-0.4	-0.2	0.3	0.4	0.1	2.6	0.1
Standing height	0.4	3.8	22.4	1.0	1.4	1.5	0.1	0.8	0.9	2.1	1.9	-1.6	4.7	1.5
Length of working week for main job	0.9	1.0	3.3	0.8	1.8	1.2	0.1	-0.5	-0.6	0.2	1.1	-0.4	-1.4	1.2
Exposure to tobacco smoke at home	0.7	0.8	3.0	-0.1	0.4	0.1	1.0	0.8	1.7	-1.0	0.5	0.8	-1.4	0.1
Breastfed as a baby	0.6	0.8	2.8	-1.0	-0.5	-1.0	-1.0	1.0	0.2	0.3	-0.6	-1.7	-0.2	-1.0
Tense / ‘highly strung’	1.2	2.0	4.4	1.8	1.6	1.3	1.6	-0.5	-0.7	2.1	1.2	1.1	1.4	1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.1	-0.4	-0.9	-0.5	-1.0	0.4	-0.1	0.8	-0.5	0.5	0.0	-0.5
Hair/balding pattern: Pattern 4	0.9	2.2	5.6	1.2	2.4	1.4	1.8	0.6	0.5	2.1	1.4	0.6	1.7	1.4
Birth weight of first child	0.6	1.2	2.0	1.1	-0.9	1.3	1.2	0.6	0.6	1.4	1.3	0.3	1.3	1.3
Peak expiratory flow (PEF)	0.4	0.8	2.8	-0.1	-1.1	-0.0	-0.6	1.3	1.0	0.7	0.2	-1.7	-1.1	-0.0
Pulse wave reflection index	2.3	2.9	7.1	-2.7	-0.6	-2.5	-1.2	1.3	1.2	-0.9	-2.1	0.7	-0.7	-2.5
Ever highly irritable/argumentative for 2 days	1.1	1.3	3.6	1.9	-0.1	0.9	1.8	0.2	0.2	1.1	1.4	1.4	0.8	0.9
Loud music exposure frequency	0.2	0.3	0.7	0.3	-0.2	0.3	0.1	0.1	-0.2	-0.7	-0.9	0.8	-0.9	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.1	-0.4	-0.5	-0.0	-0.0	-0.2	0.6	0.3	-0.8	0.7	-0.5
Mouth/teeth dental problems: Bleeding gums	0.9	1.2	2.5	-0.4	-0.1	-1.3	-0.7	-1.2	-1.0	-1.6	-1.5	0.6	-1.2	-1.3
Blood clot in the leg (DVT)	1.7	2.2	8.8	0.9	3.0	1.4	0.7	1.2	0.7	1.0	1.7	0.4	2.1	1.4
Medication: Paracetamol	0.6	1.1	3.1	1.1	-0.4	0.7	1.5	0.4	0.0	1.8	0.7	1.4	1.1	0.7
Headache pain in last month	0.5	0.9	2.1	-1.0	0.4	-1.5	0.5	0.5	1.0	-0.7	-1.4	0.5	-0.3	-1.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.3	0.3	-0.1	-0.5	-0.0	-0.7	-0.2	0.6	-0.2	-1.1	-0.7	-0.5
Glaucoma (self-reported)	1.3	1.6	5.2	1.0	1.2	1.3	0.6	0.7	0.6	1.6	1.6	-0.2	2.3	1.3
Gout (self-reported)	1.0	1.3	2.9	1.7	1.4	1.5	1.0	0.6	0.6	-0.2	1.3	-0.4	1.1	1.5
Hypothyroidism/myxoedema (self-reported)	1.5	2.8	5.1	-1.9	-1.7	-1.8	-1.7	-0.0	0.2	-2.1	-1.7	-1.9	-2.2	-1.8
Medication: Amlodipine	0.5	0.7	1.9	-0.7	-1.2	-0.8	0.1	1.0	0.7	-0.1	-0.4	1.4	-0.8	-0.8
Medication: Ventolin 100micrograms inhaler	2.5	3.2	10.0	2.4	0.7	1.8	2.4	0.8	0.9	3.2	1.9	0.5	1.0	1.8
Birth weight	0.3	0.6	5.1	0.5	-0.0	0.2	-0.0	0.4	0.2	1.0	-0.1	-2.3	0.6	0.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.3	1.3	1.0	1.5	-0.1	-2.1	-1.6	-0.1	1.0	0.2	0.6	1.6
High blood pressure (siblings)	2.8	4.0	7.7	-2.5	-2.3	-2.4	-2.6	-1.1	-1.0	-2.8	-1.8	-0.3	-0.9	-2.4
Forced vital capacity (FVC), Best measure	0.1	0.5	4.1	-0.1	-0.4	0.3	-0.8	0.5	-0.0	0.6	0.3	-2.0	-0.2	0.3
Body fat percentage	0.5	2.0	11.3	-0.3	-1.4	0.1	2.1	0.9	1.4	0.2	-0.4	3.4	-1.3	0.1
Leg fat percentage (right)	0.6	2.2	12.3	-1.0	-1.3	-0.4	1.6	0.5	1.4	-0.4	-0.8	3.5	-1.9	-0.4
Arm fat-free mass (right)	0.1	0.6	4.1	-0.9	-0.6	0.0	-0.5	-0.2	-0.0	0.3	0.3	0.9	2.0	0.0
Exposure to tobacco smoke outside home	0.6	0.8	5.3	0.2	0.3	-0.8	1.2	-0.5	-0.0	-0.6	-0.1	2.3	0.1	-0.8
Comparative body size at age 10	0.5	1.4	3.3	1.6	1.3	1.8	1.0	-0.8	-0.3	0.5	1.3	0.9	-0.5	1.8
Number of full brothers	0.2	0.2	0.8	0.2	-0.4	0.3	0.1	-0.3	-0.8	0.9	0.6	0.0	0.4	0.3
Worry too long after embarrassment	0.5	0.9	2.3	-0.3	-0.9	-1.2	0.2	-0.3	0.3	0.6	-1.4	-1.5	0.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.5	2.2	0.2	-0.9	-0.1	0.4	-0.6	-0.3	-0.0	-1.0	1.5	-0.4	-0.1
Wheeze or whistling in the chest in last year	0.3	0.5	2.3	0.4	-0.3	0.2	1.5	0.1	0.2	0.4	0.7	1.2	-0.8	0.2
Number of children fathered	0.5	0.5	1.6	-0.7	-0.6	-0.8	-0.2	1.0	0.8	1.3	-0.4	-0.3	0.0	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	5.8	0.6	1.3	0.6	1.1	1.5	1.3	2.4	1.4	0.8	0.6	0.6
Age at first live birth	0.4	0.7	2.8	-0.1	-0.1	-0.4	-1.0	1.3	0.8	0.9	0.0	-1.7	-0.2	-0.4
Pulse wave peak to peak time	1.6	1.8	7.7	0.5	-0.7	0.0	-0.7	-2.8	-2.6	-1.1	0.1	-1.6	-0.8	0.0
Health satisfaction	0.6	0.8	1.5	1.0	1.0	1.1	1.2	0.3	0.5	0.3	1.0	1.1	-0.6	1.1
Shortness of breath walking on level ground	0.9	1.0	5.2	-0.6	-1.3	-0.3	-0.4	-0.8	-0.6	-1.4	-0.7	0.4	-2.3	-0.3
Qualifications: College or University degree	0.8	2.5	9.9	0.2	0.8	0.0	-0.5	3.2	2.7	0.6	0.0	-2.9	0.2	0.0
Eye problems/disorders: None of the above	0.7	0.9	3.5	0.1	0.8	-0.5	1.1	1.9	1.7	0.6	0.0	0.6	-0.1	-0.5
Mouth/teeth dental problems: Loose teeth	1.1	1.3	5.8	-0.4	0.0	-0.6	-0.7	-2.4	-1.8	-1.5	-0.7	-0.3	-0.9	-0.6
Emphysema/chronic bronchitis	0.5	0.5	1.6	-0.7	-1.0	-0.6	-0.0	-0.5	-0.2	-0.5	-1.3	-0.9	-0.9	-0.6
Medication for pain relief, constipation, heartburn	0.8	1.3	3.4	-1.2	-0.5	-1.4	-1.3	-0.4	-0.2	-0.7	-1.2	-1.8	-1.2	-1.4
Neck or shoulder pain in last month	4.4	6.3	14.9	-3.1	-3.4	-3.2	-1.8	-0.0	0.5	-1.8	-3.9	-0.8	-2.3	-3.2
Medication: Blood pressure	0.4	0.6	2.8	-0.3	-0.2	0.1	-0.1	1.7	1.0	-0.2	0.1	1.2	1.2	0.1
Angina (self-reported)	0.5	0.7	3.3	-0.0	-0.4	0.4	0.7	0.6	0.5	0.3	0.0	1.8	-1.5	0.4
Migraine (self-reported)	0.9	1.1	2.0	1.1	1.1	1.3	1.2	0.3	0.2	0.9	1.4	0.9	1.1	1.3
Medication: Ibuprofen	0.3	0.4	1.6	0.3	-0.2	0.5	-0.3	-1.3	-1.2	-0.8	-0.2	0.2	0.1	0.5
Medication: Allopurinol	1.4	1.9	5.1	2.2	1.4	1.7	1.1	0.3	0.1	0.5	1.4	-0.5	2.0	1.7
Medication: Omeprazole	0.5	0.6	2.2	-0.6	-0.6	-0.8	-0.5	0.0	0.9	-1.5	-0.7	-0.1	-0.8	-0.8
Medication: Seretide 50 evohaler	0.2	0.3	1.1	-0.1	0.1	0.1	0.9	0.4	0.6	1.0	0.0	0.7	0.1	0.1
Mean time to correctly identify matches	1.0	2.0	3.6	0.8	1.5	1.9	1.0	1.7	1.6	1.1	1.9	0.7	-0.4	1.9
Heart disease (mother)	0.9	1.0	2.8	-1.6	-1.7	-1.1	-1.4	0.1	0.1	-0.4	-0.5	-1.0	0.4	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	1.6	0.7	-0.1	-0.2	0.4	-0.7	-0.6	0.8	0.2	-0.4	1.3	-0.2
Whole body fat mass	0.4	1.5	9.4	-0.2	-1.1	0.3	1.8	0.6	1.1	0.5	-0.1	3.1	-0.3	0.3
Leg fat mass (right)	0.4	1.5	9.8	-0.4	-1.1	0.0	1.8	0.6	1.2	0.2	-0.3	3.1	-0.8	0.0
Arm predicted mass (right)	0.1	0.7	4.3	-0.9	-0.3	-0.1	-0.8	-0.7	-0.5	0.0	0.3	0.9	2.1	-0.1
Pulse rate, automated reading	0.1	0.5	1.9	-0.3	-0.8	-0.4	-0.4	0.6	0.7	-0.2	-1.1	-1.4	0.1	-0.4
Alcohol intake frequency.	0.2	0.4	1.3	-0.5	-0.3	-0.6	-0.0	-0.1	0.0	-0.6	-0.5	1.1	1.1	-0.6
Comparative height size at age 10	0.6	3.2	9.1	1.6	1.0	1.9	1.4	1.1	1.3	1.9	2.3	-0.9	3.0	1.9
Number of full sisters	1.3	1.5	6.9	-0.4	-1.0	-0.6	-0.7	-0.7	-0.3	-2.4	-1.1	0.3	-2.6	-0.6
Suffer from ‘nerves’	0.3	0.4	1.0	0.5	0.5	-0.2	0.9	-0.8	-0.4	0.5	0.0	0.9	1.0	-0.2
Overall health rating	0.4	0.8	4.8	-0.3	-1.0	-0.4	1.1	0.7	0.5	-0.1	-0.3	2.2	-0.0	-0.4
Chest pain or discomfort	0.8	1.1	4.4	-0.8	-1.5	-0.7	0.8	0.7	1.1	-0.9	-1.0	-0.3	-2.1	-0.7
Had major operations	0.2	0.2	1.1	-0.3	-0.0	-0.3	0.2	0.1	0.3	1.1	-0.6	0.5	0.2	-0.3
Age at last live birth	0.2	0.4	0.9	-0.2	-0.9	-0.6	-0.8	0.1	-0.4	-0.1	-0.4	-0.9	-0.8	-0.6
Family relationship satisfaction	0.6	0.8	2.8	-0.2	-1.7	-0.8	0.2	1.4	1.0	0.7	-0.6	-0.4	-0.7	-0.8
Leg pain on walking	0.6	0.8	4.1	-0.5	0.5	-0.1	-1.1	0.8	0.8	-0.7	0.4	-0.9	2.0	-0.1
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	7.4	-0.6	-0.7	-0.5	-1.5	-2.7	-2.1	-1.5	-1.0	-0.4	0.7	-0.5
Commuting to job workplace: Car/motor vehicle	1.2	1.3	2.8	1.2	-0.4	0.6	1.0	-1.2	-1.7	1.6	0.7	1.6	1.2	0.6
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.2	0.4	1.6	0.7	-0.2	0.2	0.5	0.1	1.3	-1.9	2.0	0.7
Medication: Aspirin	0.4	0.5	2.2	-0.6	-1.4	0.2	-0.5	-0.0	-0.6	-0.5	0.1	1.5	0.3	0.3
Supplements: Vitamin C	1.0	1.2	3.0	-1.3	-1.0	-1.4	-0.7	1.1	0.7	-0.0	-0.9	-1.7	0.3	-1.4
Knee pain experienced in last month	0.5	0.8	3.1	-0.3	-0.4	0.4	0.3	0.6	1.0	1.7	0.7	0.1	1.8	0.4
Hypertension (Self-reported)	0.2	0.5	1.7	-0.9	0.0	-0.7	-0.3	0.8	0.4	0.3	-0.8	1.3	0.9	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	1.7	-0.8	-0.7	-0.7	-0.9	-1.0	-0.6	-1.3	-0.8	-0.5	0.8	-0.8
Illnesses of father: Heart disease	0.3	0.5	1.3	-0.6	-1.1	-0.9	-0.9	-0.3	-0.4	-0.4	-0.7	-0.3	-0.0	-0.9
Illnesses of siblings: Diabetes	0.8	1.0	3.5	-1.1	-1.3	-1.3	-0.4	0.4	0.4	-0.7	-0.9	-0.2	-1.9	-1.3
Smoking status: Previous	0.4	0.6	1.9	-0.8	0.2	-0.5	-0.8	0.9	0.9	-0.5	-1.0	-1.4	-0.1	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	6.0	1.4	0.8	0.8	1.4	0.4	-0.1	2.0	0.8	0.6	2.4	0.8
Whole body fat-free mass	0.1	0.8	6.9	-0.3	-0.2	0.4	-0.3	-0.1	0.0	0.7	0.7	0.5	2.6	0.4
Leg fat-free mass (right)	0.1	0.8	5.7	0.3	-0.5	0.7	0.3	0.1	0.1	0.9	0.9	0.4	2.4	0.7
Arm fat percentage (left)	0.5	2.1	7.5	-0.9	-2.2	-0.7	1.4	0.7	1.2	-0.4	-1.2	2.7	-2.0	-0.7
Average weekly red wine intake	1.7	2.5	7.2	-1.7	-0.7	-1.8	-2.1	0.6	0.5	-1.0	-2.0	-2.7	-0.7	-1.8
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	-0.2	-0.2	-0.2	-0.3	-0.2	-0.1	-0.3	0.4	-0.7	0.1	-0.2
Mood swings	0.4	0.8	3.5	0.7	1.0	0.4	-0.2	-1.9	-1.6	-0.1	0.2	0.9	0.2	0.4
Loneliness, isolation	0.9	1.2	2.9	-1.1	-0.7	-1.5	-0.7	-0.9	0.2	-1.7	-1.6	-0.5	-0.0	-1.5
Long-standing illness, disability or infirmity	0.3	0.5	1.7	-0.3	0.2	0.5	-0.5	-0.6	-0.4	-1.3	0.4	1.1	-0.8	0.5
Ever had bowel cancer screening	0.5	0.5	2.0	-1.0	-0.2	-0.7	-1.4	-0.1	-0.3	-0.5	-1.1	-0.0	-0.5	-0.7
Diabetes diagnosed by doctor	0.5	0.8	3.8	-0.4	-0.2	0.1	0.1	1.9	1.6	-0.2	-0.0	-0.1	1.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.5	0.5	0.5	0.9	0.7	-0.2	-0.5	0.4	0.3	1.6	-0.5	0.9
Friendships satisfaction	0.8	0.9	2.0	-0.9	-0.8	-1.0	-0.3	1.3	1.0	-0.1	-0.9	-1.1	-1.4	-1.0
Qualifications: nursing, teaching	1.2	1.8	8.1	-1.3	0.2	-1.4	-1.7	0.5	0.0	-0.1	-1.0	-2.9	-1.6	-1.4
Commuting to job workplace: Walk	1.1	1.2	6.5	-0.7	-0.5	-1.2	-0.4	-0.6	-0.5	-1.2	-0.9	0.4	-2.5	-1.2
Eye problems/disorders: Cataract	0.9	1.0	3.3	0.0	-0.7	0.7	-1.1	-1.8	-1.8	-0.0	0.0	-1.4	0.1	0.7
Mouth/teeth dental problems: Mouth ulcers	2.1	3.3	7.2	-2.0	-0.9	-2.7	-0.7	2.1	2.4	-0.1	-2.0	-1.6	-0.2	-2.7
Medication for cholesterol	0.4	0.7	2.6	0.8	-1.2	0.6	-0.1	-0.4	-0.4	-0.4	0.5	-1.1	-1.6	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	5.7	-0.4	-0.0	-0.8	0.6	-0.2	0.2	-1.1	-0.8	2.1	-2.4	-0.8
Back pain experienced in last month	0.5	0.8	2.6	-1.3	-1.6	-0.9	-0.9	-0.2	0.6	-0.6	-0.9	0.1	0.3	-0.9
Mineral and other dietary supplements	2.2	3.0	5.5	2.4	0.2	2.1	1.1	-2.3	-2.0	0.1	2.2	1.4	0.7	2.1
Breast cancer (self-reported)	0.4	0.4	2.3	-0.1	-1.0	0.1	0.2	0.7	0.9	-0.3	0.0	0.1	-1.5	0.1
Asthma (self-reported)	0.4	0.7	4.1	-0.4	-0.6	-0.4	0.0	1.1	1.3	0.2	0.2	0.0	-2.0	-0.4
Osteoporosis (self-reported)	2.4	3.0	6.3	1.9	1.4	2.5	2.0	0.5	0.9	-0.2	2.0	2.1	1.1	2.5
Osteoarthritis (self-reported)	2.2	2.9	5.6	-2.0	-2.1	-1.0	-2.3	-2.4	-1.9	-2.2	-0.9	-0.4	-0.6	-1.0
Medication: Aspirin	0.4	0.5	1.5	-0.9	-0.9	0.1	-0.7	-0.2	-0.5	-1.0	-0.3	1.2	-0.5	0.1
Medication: Gliclazide	0.5	0.5	2.2	-0.2	-1.5	0.2	-0.3	-0.6	-1.3	-0.4	0.2	0.3	1.1	0.2
Illnesses of father: None of the above (group 1)	0.5	0.6	2.2	0.4	1.4	0.7	0.5	0.5	0.8	-1.5	0.1	-0.3	0.6	0.7
Smoking status: Current	1.0	1.6	7.7	-0.5	-0.5	-0.5	0.8	-1.6	-1.5	-0.8	-1.1	2.8	-1.4	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	0.5	1.0	0.3	-0.4	-0.1	-0.3	1.4	0.6	-1.0	0.1	0.3
Whole body water mass	0.1	0.8	6.5	-0.4	-0.4	0.4	-0.3	-0.1	-0.0	0.7	0.6	0.5	2.6	0.4
Leg predicted mass (right)	0.1	0.8	5.8	0.3	-0.5	0.7	0.2	0.1	0.1	0.9	0.8	0.4	2.4	0.7
Arm fat mass (left)	0.3	1.3	7.7	-0.8	-1.8	-0.3	1.1	0.2	0.6	-0.2	-0.7	2.8	-0.9	-0.3
Number of self-reported non-cancer illnesses	0.3	0.5	2.2	-1.5	0.1	-0.4	-1.3	0.0	-0.1	-1.1	-0.5	0.5	-0.4	-0.4
Average weekly champagne plus white wine intake	0.2	0.2	1.1	0.7	0.0	0.1	-0.1	0.2	0.3	0.1	0.3	-1.0	1.0	0.1
Miserableness	0.3	0.6	2.2	-0.8	-0.6	-0.8	-0.2	0.1	0.8	-0.0	-1.0	-1.5	0.3	-0.8
Guilty feelings	0.3	0.4	1.0	-0.6	-0.3	-1.0	0.2	0.4	1.0	0.0	-0.8	-0.6	0.3	-1.0
Wears glasses or contact lenses	0.6	0.6	1.5	-1.2	-1.0	-1.1	-0.9	0.2	0.2	-0.3	-0.9	-0.5	-0.4	-1.1
Ever taken oral contraceptive pill	0.3	0.3	1.4	0.3	-0.1	-0.2	0.7	-0.7	-0.3	-0.1	-1.2	0.6	0.4	-0.2
Hearing aid user	0.7	0.8	3.4	-0.3	-1.1	-0.1	1.1	0.9	1.3	0.7	-0.3	-0.2	1.8	-0.1
Mother’s age at death	1.2	1.5	4.0	-0.2	0.6	0.5	-2.0	-1.9	-1.9	-0.9	0.5	-1.0	1.4	0.5
Financial situation satisfaction	1.2	1.5	3.2	-1.0	-1.0	-1.4	-0.3	-1.5	-1.2	-1.8	-1.2	1.0	-1.4	-1.4
Tinnitus: Yes, now most or all of the time	1.2	1.4	6.1	-0.7	0.1	-0.5	-0.7	2.5	2.1	-0.6	-0.6	-1.4	1.2	-0.5
Commuting to job workplace: Public transport	0.5	0.6	4.0	-0.6	-0.5	-0.3	-0.6	0.5	1.0	-0.7	-0.3	-2.0	-0.1	-0.3
Eye problems/disorders: Glaucoma	1.6	1.9	3.7	1.6	1.5	1.7	0.9	-0.3	-0.1	1.6	1.8	0.1	1.9	1.7
Medication: Blood pressure	0.2	0.4	3.0	-0.5	0.2	-0.3	-0.3	-0.3	-0.3	0.1	-0.1	1.7	1.1	-0.3
Pain type(s) experienced in last month: Hip pain	1.0	1.3	4.0	-1.1	-1.9	-0.7	-1.6	-0.5	-0.4	-0.5	-0.8	-2.0	0.0	-0.7
Supplements: Fish oil (including cod liver oil)	2.7	3.5	7.7	-2.8	-0.2	-2.8	-1.6	1.3	1.1	-0.6	-2.8	-1.2	-1.1	-2.8
High cholesterol (Self-reported)	0.7	1.2	4.1	0.3	0.7	1.7	-0.5	-0.4	-0.6	-0.4	1.0	-0.2	2.0	1.7
Medication: Bendroflumethiazide	1.2	1.8	6.8	-1.4	0.9	-1.3	0.5	1.8	1.6	-0.2	-0.8	2.6	0.7	-1.3
Medication: Paracetamol	0.4	0.6	2.2	0.8	-0.8	0.6	1.4	0.0	-0.1	0.7	0.2	1.5	-0.6	0.6
Medication: Lisinopril	0.4	0.6	1.8	0.8	0.8	0.6	0.5	0.6	0.4	-1.4	0.8	0.8	-0.6	0.6
Medication: Atorvastatin	2.0	2.5	10.6	-0.9	0.5	-0.4	0.1	3.2	3.2	1.1	-0.0	-1.9	0.6	-0.4
Illnesses of father: High blood pressure	1.3	1.6	7.8	0.6	1.1	0.7	-0.3	0.6	-0.1	2.8	1.1	-1.4	1.8	0.7
Alcohol drinker status: Never	0.7	0.9	2.0	1.3	0.9	1.4	1.0	0.8	0.2	-0.4	1.0	0.6	0.4	1.4
Ever smoked	0.5	0.8	2.2	-1.0	-1.5	-1.2	-0.2	0.5	0.2	-0.1	-1.3	0.6	-1.0	-1.2
Basal metabolic rate	0.1	0.7	5.2	-0.3	-0.6	0.4	0.0	-0.1	0.1	0.7	0.6	1.0	2.3	0.4
Leg fat percentage (left)	0.6	2.2	12.0	-0.9	-1.2	-0.3	1.6	0.6	1.3	-0.5	-0.7	3.5	-2.1	-0.3
Arm fat-free mass (left)	0.1	0.6	4.0	-0.4	-0.2	0.4	-0.3	-0.4	-0.1	0.4	0.7	1.2	2.0	0.4
Number of operations (self-reported)	0.2	0.3	0.6	-0.7	-0.7	-0.5	-0.3	-0.3	-0.2	-0.0	-0.7	0.8	-0.2	-0.5
Average weekly beer plus cider intake	4.5	6.5	19.5	2.2	2.0	2.8	2.8	-0.4	-0.5	3.0	3.0	4.4	1.4	2.8
Irritability	0.9	1.5	6.5	1.3	0.2	0.5	1.7	-0.7	-0.9	2.6	0.6	1.7	0.6	0.5
Risk taking	0.7	1.0	3.5	-0.4	0.3	0.5	-1.4	-1.3	-1.4	-1.9	-0.4	-0.7	-0.8	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.2	-0.3	-0.8	0.1	-0.4	0.6	0.2	-0.9	-0.3	-0.9	-1.1	0.1
Fractured/broken bones in last 5 years	1.3	1.6	4.8	1.3	1.2	1.0	2.2	0.3	0.0	2.1	1.2	0.8	1.3	1.0
Age started oral contraceptive pill	2.2	2.8	6.6	-2.1	-0.4	-1.3	-2.6	0.3	0.5	-2.3	-1.6	-2.2	-1.6	-1.3
Diastolic blood pressure, automated reading	0.6	1.8	6.3	-0.5	-1.5	-1.0	-1.0	-2.4	-2.5	0.4	-1.2	0.2	-0.7	-1.0
Ever depressed for a whole week	1.4	1.8	4.0	-0.9	-1.9	-1.4	-1.4	-0.2	-0.2	-1.9	-2.0	-0.6	-1.1	-1.4
Unable to work because of sickness or disability	0.8	1.1	2.5	0.9	-1.6	0.2	1.6	1.3	1.0	0.5	0.7	1.6	-0.4	0.2
Commuting to job workplace: Cycle	1.1	1.4	3.2	-1.4	-1.3	-0.7	-1.8	0.5	1.0	-1.1	-0.6	-1.6	-1.2	-0.7
Myopia	0.6	0.9	2.3	0.6	1.5	0.5	1.2	1.0	1.1	0.7	0.7	1.4	0.5	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.4	2.6	0.8	-0.3	0.6	0.2	-0.3	0.1	-0.1	0.6	-1.6	-0.6	0.6
Cholesterol lowering medication	0.3	0.4	1.1	-0.9	-1.0	-0.2	-0.4	0.9	0.8	0.3	-0.3	0.5	0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	1.9	-0.9	-0.8	-1.4	-0.9	0.8	1.3	-1.3	-1.2	-0.7	-1.0	-1.4
Pain experienced in last month	1.2	1.9	6.6	1.3	1.7	1.2	0.0	-2.0	-2.6	-0.5	1.5	0.8	-0.3	1.2
Supplements: Calcium	0.7	0.8	2.7	-0.6	0.6	-0.4	-0.6	1.0	1.5	-1.6	-0.5	-0.3	-0.7	-0.4
Basal cell carcinoma (self-reported)	1.5	1.7	7.9	-1.0	-2.3	-0.8	-1.1	-0.5	-1.0	-0.1	-0.5	-1.0	-2.8	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.7	0.2	-0.6	0.5	-0.0	1.3	0.6	-0.5	-0.8	0.9	-0.9	0.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.7	7.2	0.7	2.7	1.2	0.5	1.0	0.7	0.9	1.6	0.0	1.9	1.2
Heart disease (siblings)	0.7	0.8	2.5	-1.2	-1.1	-0.7	-0.5	1.4	1.6	-0.0	-0.7	-0.5	0.2	-0.7
Alcohol drinker status: Previous	0.8	1.0	3.5	0.3	-0.2	0.7	0.9	0.9	1.1	1.3	1.1	0.6	1.9	0.7
Pack years of smoking	1.0	1.5	4.8	-1.7	-1.0	-1.0	-0.9	-0.5	0.6	-2.2	-1.7	0.2	-1.2	-1.0
Impedance of whole body	0.2	1.1	3.4	1.3	0.9	0.5	1.8	1.3	1.4	1.3	0.2	-0.5	-0.8	0.5
Leg fat mass (left)	0.4	1.6	10.3	-0.4	-1.1	0.0	1.7	0.8	1.3	0.2	-0.3	3.2	-0.8	0.0
Arm predicted mass (left)	0.1	0.6	3.6	-0.5	-0.6	0.3	-0.1	-0.4	-0.3	0.5	0.4	1.3	1.9	0.3