Hub : Genes

RP11-25K19.1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.0954 0.0387 5.3e-03 0.003 NA 0.000 NA 0.001 1.7e-01 NA 3.3e-01 NA 2.4e-01
2 GTEx Heart Left Ventricle 0.2909 0.0620 1.3e-06 0.100 NA 0.112 NA 0.095 5.5e-06 NA 1.5e-06 NA 9.9e-06
3 ROSMAP Brain Pre-frontal Cortex 0.0780 0.0265 6.1e-04 0.032 0.035 0.044 0.04 0.034 4.7e-05 2.1e-05 2.1e-06 6e-06 2.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.1 0.2 0.3 0.4 -0.5 0.5
Bipolar Disorder or Schizophrenia 0.4 0.9 1.9 0.7 -1.4 0.6
Depressed Affect (Nagel 2018) 0.7 1.4 4.2 -2.1 -0.1 -0.1
Depression (Nagel 2018) 1.7 2.6 3.4 -1.8 -1.5 1.5
Intelligence (Savage-Jansen 2018) 0.5 1.7 2.3 1.5 -0.8 -1.4
Neuroticism (Nagel 2018) 0.5 1.2 2.1 -0.1 1.2 -1.4
Schizophrenia (2018) 0.4 0.8 1.9 0.6 -1.4 0.6
Schizophrenia vs Biploar Disorder 1.3 1.7 2.4 -1.5 -0.9 1.4
Worry (Nagel 2018) 2.1 4.4 7.6 -0.8 2.2 -2.8
Alzheimer’s Disease (in mother) 0.9 1.0 1.6 0.5 1.2 1.1
Alzheimer’s Disease (in father) 0.4 0.4 0.9 0.9 -0.5 -0.3
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 0.4 0.6 0.3
Crohns Disease (2017) 1.2 2.6 4.2 -2.0 1.9 0.3
Irritable Bowel Disease (IBD) 1.2 2.9 7.6 -2.8 0.8 0.6
Ulcerative Colitis (UC) 1.4 2.6 5.6 -2.4 -1.0 1.0
Major Depression (MDD) 0.7 0.9 2.2 -1.5 0.6 0.1
Reaction Time 0.3 0.6 1.8 1.4 -0.2 0.1
Verbal and Numeric Reasoning (VNR) 0.6 1.3 2.5 1.0 0.8 -1.6
Breast Cancer 0.9 2.2 4.3 0.0 1.5 -2.1
Ovarian Cancer 1.3 1.7 2.8 1.3 1.7 -0.7
Prostate Cancer 0.7 1.0 2.3 -0.7 -0.1 1.5
Age at First Birth 0.3 0.4 1.2 1.1 0.0 -0.2
Bipolar Disorder (2011) 0.8 0.8 1.3 0.7 -1.2 0.8
Body Mass Index (BMI) (2010) 2.4 3.3 6.3 0.1 2.5 -1.9
Coronary Artery Disease (CAD) 3.0 3.6 4.8 2.2 -1.9 1.6
Crohns Disease (2012) 0.8 1.3 3.6 -0.6 0.2 1.9
Mean Putamen Volume 0.6 0.6 1.3 1.2 -0.0 0.8
Fasting Glucose 1.2 1.5 2.9 -0.9 0.8 1.7
HbA1C 0.6 0.7 1.9 -1.4 0.0 0.3
HDL Cholesterol 0.2 0.3 0.6 0.5 -0.7 -0.2
LDL Cholesterol 0.3 0.4 1.0 1.0 -0.2 -0.5
Lupus 0.8 1.2 2.9 -0.4 -0.7 1.7
Neuroticism (2016) 2.1 3.0 7.4 -2.7 0.8 -1.1
Primary Biliary Cirrhosis 0.7 1.0 1.6 1.2 -1.0 0.5
Rheumatoid Arthritis 1.9 2.7 7.2 -2.7 0.4 0.8
Schizophrenia (2014) 0.7 1.5 3.5 -0.2 -1.9 1.0
Triglycerides 0.5 0.9 1.6 0.1 -1.3 1.0
Type 2 Diabetes (T2D) (2012) 1.5 1.7 2.0 1.4 1.2 -1.3
Ulcerative Colitis 0.2 0.2 0.7 -0.8 0.1 -0.0
Blood Eosinophil Count 0.5 3.9 7.4 2.7 1.6 -1.4
Blood Platelet Count 0.1 1.4 2.2 -1.4 1.5 0.1
Blood Red Count 0.1 0.5 0.9 0.9 -0.7 -0.5
Blood White Count 0.3 2.5 3.1 -1.8 1.5 -1.5
Heel T-Score 0.1 0.9 1.3 0.8 0.9 1.1
BMI 0.8 4.6 8.0 -2.8 2.4 -0.2
Height 0.2 3.4 7.4 -1.7 2.7 0.0
Waist Hip Ratio (WHR) 1.2 5.3 10.7 -3.3 2.1 -1.0
Systolic Blood Pressure 1.8 8.8 17.5 -0.1 -4.2 3.0
Smoking Status 2.9 7.0 20.7 -4.6 0.4 -0.1
Allergy or Eczema 0.1 0.2 0.6 0.3 -0.8 0.1
Cardiovascular Disease 0.5 1.6 4.3 -2.1 -0.2 0.7
Hypothyroidism (self reported) 0.1 0.1 0.3 -0.3 -0.2 0.6
Respiratory disease 1.1 2.4 4.3 -0.9 -1.4 2.1
Type 2 Diabetes (T2D) (2018) 2.6 4.9 10.0 -3.2 1.6 -1.5
Lung FEV1/FVC ratio 0.5 2.7 4.3 -1.9 2.1 -0.4
Lung FVC 0.8 4.2 6.6 1.4 2.6 -2.0
Neuroticism 0.0 0.1 0.2 -0.0 -0.3 -0.5
Chronotype (morning person) 3.9 9.0 14.6 3.8 -3.4 0.9
Hair Pigment 0.0 0.5 1.1 -0.5 0.3 -1.0
Tanning 0.1 0.7 1.9 1.4 0.3 0.1
Hand grip strength (left) 1.1 2.8 5.3 -2.3 -0.1 1.8
Number of treatments/medications taken 3.2 5.8 13.1 -3.6 1.9 -0.9
Average weekly spirits intake 1.2 1.5 2.0 -1.4 1.4 -0.7
Sensitivity / hurt feelings 1.9 3.2 7.3 2.7 0.9 -1.2
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.2 -0.5 -1.5 0.4
Hearing difficulty/problems: Yes 1.8 2.7 5.9 2.4 -1.2 0.9
Relative age of first facial hair 0.2 0.5 1.1 0.6 0.0 -1.0
Other serious medical condition/disability diagnosed by doctor 2.9 3.8 9.9 -3.2 -1.0 0.6
Ever used hormone-replacement therapy (HRT) 2.0 2.6 3.9 -0.6 1.9 -2.0
Ever had hysterectomy (womb removed) 0.7 0.7 2.0 0.1 1.4 -0.5
Systolic blood pressure, automated reading 0.4 1.0 2.0 -0.2 -1.4 1.0
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.8 -1.3 0.3 1.1
Angina 0.2 0.3 0.6 0.4 -0.4 0.8
Medication for hormone replacement therapy 0.5 0.6 1.1 -1.0 -0.4 -0.7
Vitamin and mineral supplements 0.5 0.7 1.8 1.3 -0.3 0.2
Supplements: Zinc 2.0 2.1 4.0 -0.2 2.0 -1.5
Medication: Co-codamol 3.1 3.6 5.4 -1.7 2.3 -1.5
Medication: Metformin 2.7 3.8 9.5 -3.1 1.3 -0.6
Diabetes (father) 0.8 0.9 2.4 -1.6 0.6 0.2
Diabetes (mother) 1.3 1.6 4.4 -2.1 -0.3 0.6
Severe depression (siblings) 0.3 0.3 0.7 -0.4 0.8 -0.4
Pack years adult smoking proportion 0.1 0.1 0.2 -0.2 0.1 -0.5
Impedance of leg (right) 1.4 6.8 12.3 -2.8 -3.5 0.5
Leg fat-free mass (left) 0.5 2.6 6.7 -1.0 2.6 0.4
Trunk fat percentage 1.4 5.6 16.1 -4.0 0.3 0.9
Hand grip strength (right) 0.5 1.3 2.4 -1.5 -0.1 1.2
Townsend deprivation index at recruitment 0.6 0.9 2.5 -1.6 -0.4 -0.2
Current tobacco smoking 0.9 1.5 3.0 -1.7 0.3 -1.1
Average weekly fortified wine intake 0.8 1.0 2.4 -1.6 0.8 -0.0
Maternal smoking around birth 4.2 6.0 8.9 -3.0 -2.7 1.3
Fed-up feelings 1.3 2.3 5.5 -2.3 0.4 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.8 2.4 3.3 -1.8 -1.4 1.4
Relative age voice broke 0.1 0.1 0.3 -0.6 0.1 0.2
Taking other prescription medications 3.1 4.8 6.4 -2.4 2.5 -1.5
Age when periods started (menarche) 2.1 5.0 6.0 1.8 -2.4 2.5
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 3.0 -0.2 1.7 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 1.0 -0.6 0.2 1.0
Tinnitus: Yes, but not now, but have in the past 0.9 1.0 1.7 -0.2 1.1 -1.3
Qualifications: CSEs or equivalent 0.8 1.0 2.9 0.3 1.7 -0.2
Serious illness, injury or assault to yourself 1.1 1.3 3.8 -2.0 -0.4 0.1
High blood pressure 0.3 0.9 2.6 -1.6 0.1 0.3
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.2 -0.1 -0.1
Multivitamins +/- minerals 1.9 2.4 7.3 -2.7 0.1 0.0
Stomach or abdominal pain in last month 0.8 0.9 2.7 -1.6 0.4 -0.0
Supplements: Glucosamine 2.1 2.7 4.5 0.3 2.1 -1.9
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 1.5 -1.2 -1.1 0.6
Medication: Atenolol 2.0 2.6 4.1 -0.8 -2.0 1.7
Medication: Levothyroxine sodium 0.4 0.7 1.3 0.9 -0.2 1.1
Sitting height 0.0 0.2 0.6 -0.1 0.8 -0.3
Chronic bronchitis/emphysema (father) 2.0 2.3 4.0 -1.3 -2.0 1.1
High blood pressure (mother) 3.2 4.4 7.9 -0.7 -2.8 2.2
Body mass index (BMI) 0.9 3.8 7.9 -2.8 1.9 0.1
Impedance of leg (left) 1.3 6.3 12.5 -2.4 -3.5 0.7
Leg predicted mass (left) 0.5 2.8 7.1 -1.1 2.7 0.4
Trunk fat mass 1.4 6.0 16.4 -4.1 0.9 0.9
Waist circumference 1.5 5.4 10.7 -3.3 2.3 0.0
Number of incorrect matches in round 0.2 0.3 0.8 0.9 -0.2 0.5
Past tobacco smoking 2.1 3.8 11.4 3.4 0.1 -0.2
Alcohol usually taken with meals 2.7 4.4 7.1 1.4 -2.7 2.0
Nervous feelings 2.0 3.7 7.9 0.3 1.8 -2.8
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.9 -1.4 0.2 0.3
Hearing difficulty/problems with background noise 2.3 3.7 10.8 3.3 -0.4 -0.2
Hair/balding pattern: Pattern 2 0.7 0.9 1.4 -0.0 1.2 -1.2
Had menopause 2.0 2.5 4.5 0.1 2.1 -1.7
Had other major operations 0.3 0.4 1.0 0.1 0.3 -1.0
Forced vital capacity (FVC) 0.6 2.3 5.0 1.0 2.2 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.4 -0.4 0.7 0.5
Ever unenthusiastic/disinterested for a whole week 1.4 1.7 3.0 -1.4 0.6 -1.7
Qualifications: None of the above 0.3 0.6 0.9 -0.5 -0.7 0.9
Financial difficulties in last 2 years 0.9 1.2 3.0 -1.7 0.5 -0.4
Mouth/teeth dental problems 1.4 2.1 4.6 1.1 -0.9 2.1
Heart attack 1.0 1.2 2.5 0.1 -1.6 1.1
Allergy 0.1 0.2 0.6 0.8 0.1 -0.2
Pain all over the body in last month 2.7 2.9 4.9 -1.8 0.7 -2.2
Diabetes (self-reported) 3.1 4.8 13.4 -3.7 0.2 -1.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.6 -0.5 -0.3 0.8
Medication: Ramipril 0.6 0.7 1.5 -1.2 -0.6 -0.5
Medication: Simvastatin 1.4 2.0 6.0 -2.5 -0.3 -0.2
Fluid intelligence score 0.8 1.8 3.1 1.4 -1.8 0.6
Illnesses of siblings 0.8 1.2 1.9 1.0 1.4 -0.8
Neuroticism score 0.4 0.9 2.2 -0.3 0.7 -1.5
Weight 1.0 4.7 8.7 -2.9 2.3 0.6
Impedance of arm (right) 0.7 3.3 8.6 -1.0 -2.9 0.4
Arm fat percentage (right) 1.0 4.1 12.2 -3.5 0.4 0.3
Trunk fat-free mass 0.5 3.1 8.9 -0.6 3.0 0.1
Hip circumference 0.7 3.0 5.3 -2.3 1.6 1.1
Time employed in main current job 0.5 0.6 1.6 -0.1 -0.5 -1.2
Alcohol intake versus 10 years previously 0.6 1.0 1.4 -0.9 0.9 -1.2
Father’s age at death 0.9 1.2 3.5 1.9 -0.0 0.4
Worrier / anxious feelings 3.9 7.3 12.0 1.1 3.0 -3.5
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.5 2.8 -1.7 0.9 -0.9
Falls in the last year 1.6 2.2 6.0 -2.5 0.3 0.6
Hair/balding pattern: Pattern 3 0.6 1.0 2.8 -0.1 -0.3 1.7
Number of live births 0.2 0.3 0.6 0.4 -0.3 0.8
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 5.8 0.4 2.4 -0.7
Pulse rate 2.3 3.8 6.7 -2.1 0.6 -2.6
Happiness 0.8 0.9 2.5 0.2 0.5 -1.6
Noisy workplace 0.4 0.4 1.1 -0.3 1.0 -0.4
Qualifications: A levels/AS levels or equivalent 1.0 2.3 3.9 2.0 -1.7 0.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.5 0.8 -0.6 0.9 0.5
Mouth/teeth dental problems: Dentures 0.4 0.7 2.0 -0.1 -0.3 -1.4
Asthma 0.2 0.4 0.7 -0.5 0.4 0.8
Medication: Ibuprofen (e.g. Nurofen) 1.8 2.3 2.8 -1.4 -1.4 1.7
Medication: Cholesterol lowering 2.1 3.3 8.2 -2.9 -1.1 0.6
Depression (self-reported) 1.1 1.3 1.5 -1.2 -1.2 0.9
Medication: Lansoprazole 1.3 1.4 3.0 -0.5 1.0 -1.7
Prospective memory result 1.7 2.0 3.2 -1.0 1.8 -1.4
Lung cancer (father) 0.1 0.2 0.3 -0.5 -0.0 0.5
Illnesses of mother 0.5 0.6 1.5 1.2 -0.4 -0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 3.1 -0.0 1.8 -0.5
Pulse wave Arterial Stiffness index 1.5 1.7 2.2 -1.5 -1.3 1.1
Impedance of arm (left) 0.7 3.4 9.6 -0.5 -3.1 0.6
Arm fat mass (right) 1.2 4.9 12.4 -3.5 1.5 0.2
Trunk predicted mass 0.5 3.1 9.0 -0.5 3.0 0.0
Standing height 0.1 1.1 1.4 -1.0 1.0 1.2
Length of working week for main job 0.8 0.9 1.8 -1.3 0.2 -1.0
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.3 0.1 0.5
Breastfed as a baby 0.6 0.7 1.1 -0.5 1.1 -0.9
Tense / ‘highly strung’ 2.1 3.4 5.3 -1.2 2.3 -1.9
Seen doctor (GP) for nerves, anxiety, tension or depression 1.8 2.7 3.3 -1.8 1.3 -1.8
Hair/balding pattern: Pattern 4 0.3 0.7 1.6 -0.2 0.7 -1.3
Birth weight of first child 0.7 1.3 2.4 -1.6 0.9 -0.7
Peak expiratory flow (PEF) 1.2 2.7 6.5 0.2 2.5 -1.3
Pulse wave reflection index 1.0 1.3 2.0 -1.4 -0.2 1.4
Ever highly irritable/argumentative for 2 days 2.0 2.4 4.1 -1.8 2.0 -0.3
Loud music exposure frequency 0.6 0.7 1.8 -0.4 1.4 0.0
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.8 -0.1 1.3 -0.2
Mouth/teeth dental problems: Bleeding gums 3.6 4.7 7.4 -1.9 1.8 -2.7
Blood clot in the leg (DVT) 2.6 3.3 8.2 -2.9 -1.1 0.7
Medication: Paracetamol 0.9 1.5 2.6 -0.5 1.6 -1.3
Headache pain in last month 0.1 0.1 0.3 0.1 0.1 -0.6
Medication for cholesterol, blood pressure or diabetes 2.5 4.1 8.5 2.9 1.5 -1.2
Glaucoma (self-reported) 0.5 0.6 0.7 0.8 -0.8 0.6
Gout (self-reported) 1.0 1.4 2.6 1.6 0.6 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.5 0.4 0.9
Medication: Amlodipine 0.3 0.5 0.9 -0.9 0.4 -0.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.5 -0.2 0.5 1.2
Birth weight 0.6 1.3 2.9 1.7 -0.9 0.5
Chronic bronchitis/emphysema (mother) 1.2 1.4 2.0 -1.4 0.8 -1.2
High blood pressure (siblings) 1.4 2.0 3.7 -0.2 -1.9 1.5
Forced vital capacity (FVC), Best measure 0.5 2.0 4.0 0.7 2.0 -1.2
Body fat percentage 1.8 6.9 20.1 -4.5 0.1 0.8
Leg fat percentage (right) 2.8 10.1 29.9 -5.5 -0.1 0.6
Arm fat-free mass (right) 0.5 2.7 7.1 -0.8 2.7 0.7
Exposure to tobacco smoke outside home 0.7 1.0 1.7 -1.3 -0.3 1.1
Comparative body size at age 10 0.3 0.9 1.3 0.8 1.1 -0.8
Number of full brothers 1.5 1.9 2.8 -1.7 -0.7 1.6
Worry too long after embarrassment 1.4 2.3 5.2 2.3 1.0 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 1.7 2.2 6.6 -2.6 0.1 -0.0
Wheeze or whistling in the chest in last year 0.1 0.3 0.5 -0.7 0.5 0.3
Number of children fathered 1.5 1.7 2.5 -0.5 -1.5 1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.0 1.4 0.7 -1.1 1.2
Age at first live birth 1.8 3.2 6.0 -0.4 -2.4 1.8
Pulse wave peak to peak time 1.5 1.8 2.4 1.5 1.4 -1.0
Health satisfaction 1.7 2.3 5.1 -2.2 0.7 -1.1
Shortness of breath walking on level ground 0.1 0.1 0.2 0.3 -0.2 -0.5
Qualifications: College or University degree 2.0 6.3 12.6 2.5 -3.6 0.1
Eye problems/disorders: None of the above 3.9 4.5 8.3 1.1 2.0 -2.9
Mouth/teeth dental problems: Loose teeth 0.6 0.7 0.8 0.8 0.9 -0.9
Emphysema/chronic bronchitis 0.1 0.1 0.2 -0.0 0.2 -0.4
Medication for pain relief, constipation, heartburn 1.2 2.1 4.1 2.0 -1.5 -0.1
Neck or shoulder pain in last month 1.0 1.4 1.8 -1.0 1.1 -1.3
Medication: Blood pressure 1.8 3.2 4.8 -1.1 -1.9 2.2
Angina (self-reported) 0.3 0.4 0.6 0.6 -0.6 0.8
Migraine (self-reported) 1.1 1.4 3.6 1.9 -0.6 0.5
Medication: Ibuprofen 2.5 3.0 4.2 -1.6 -1.6 2.1
Medication: Allopurinol 0.3 0.4 0.9 1.0 0.1 -0.6
Medication: Omeprazole 0.1 0.2 0.3 -0.3 -0.6 0.1
Medication: Seretide 50 evohaler 0.1 0.2 0.4 0.1 0.7 -0.3
Mean time to correctly identify matches 0.3 0.6 1.8 1.3 0.3 0.1
Heart disease (mother) 0.4 0.5 1.0 -0.3 0.8 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.3 0.4 -0.5 0.6
Whole body fat mass 1.5 6.2 17.1 -4.1 1.0 0.7
Leg fat mass (right) 2.0 7.9 22.7 -4.8 0.8 0.6
Arm predicted mass (right) 0.6 3.2 8.8 -0.7 3.0 0.5
Pulse rate, automated reading 1.4 4.7 11.1 -1.6 0.6 -3.3
Alcohol intake frequency. 0.9 2.0 4.2 2.1 1.0 -0.9
Comparative height size at age 10 0.4 2.1 5.6 -0.3 2.4 -0.8
Number of full sisters 1.7 2.0 3.0 1.2 -1.7 1.3
Suffer from ‘nerves’ 0.4 0.7 1.7 -1.3 0.3 -0.5
Overall health rating 2.3 4.9 11.1 -3.3 0.9 -1.7
Chest pain or discomfort 0.3 0.4 0.8 0.9 -0.2 -0.6
Had major operations 1.3 1.5 2.6 -0.8 -1.2 1.6
Age at last live birth 2.7 3.9 7.0 -0.5 -2.6 2.2
Family relationship satisfaction 0.8 0.9 2.0 -0.5 0.7 -1.4
Leg pain on walking 0.4 0.5 0.8 0.9 0.7 -0.3
Qualifications: NVQ or HND or HNC or equivalent 1.6 2.0 3.0 -0.4 1.6 -1.7
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.9 -1.7 0.3 -0.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.4 1.6 -0.8 -0.1
Medication: Aspirin 1.7 2.3 5.3 -2.3 1.1 -0.5
Supplements: Vitamin C 0.5 0.5 0.8 0.6 0.7 -0.9
Knee pain experienced in last month 1.3 2.1 3.8 -0.6 2.0 -1.4
Hypertension (Self-reported) 0.4 1.1 3.1 -1.8 0.5 0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.4 -0.2 0.6 0.2
Illnesses of father: Heart disease 0.6 0.8 1.2 1.1 -0.7 0.9
Illnesses of siblings: Diabetes 0.6 0.7 1.8 -1.3 -0.0 0.6
Smoking status: Previous 1.3 1.9 5.1 -2.3 -0.2 0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.4 -1.2 0.4 0.5
Whole body fat-free mass 0.6 3.4 9.8 -0.6 3.1 0.1
Leg fat-free mass (right) 0.5 2.9 8.2 -0.4 2.9 0.4
Arm fat percentage (left) 0.8 3.4 9.7 -3.1 0.1 0.6
Average weekly red wine intake 5.9 8.8 14.6 -1.9 -3.8 2.8
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.5 0.7 0.3 -1.2
Mood swings 1.4 2.5 3.5 -1.3 1.5 -1.9
Loneliness, isolation 1.7 2.4 2.7 -1.6 -1.5 1.6
Long-standing illness, disability or infirmity 2.8 4.3 7.6 -2.7 2.0 -1.1
Ever had bowel cancer screening 0.8 0.9 2.2 -1.5 0.3 -0.7
Diabetes diagnosed by doctor 2.9 4.8 12.5 -3.5 0.9 -1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 1.1 0.2 -0.1 -1.0
Friendships satisfaction 0.3 0.4 0.6 -0.5 -0.5 -0.8
Qualifications: nursing, teaching 0.1 0.1 0.3 0.5 -0.4 0.2
Commuting to job workplace: Walk 0.5 0.6 0.9 0.9 -0.9 -0.1
Eye problems/disorders: Cataract 4.7 5.4 9.6 -0.4 -3.1 2.6
Mouth/teeth dental problems: Mouth ulcers 0.0 0.1 0.1 -0.0 -0.2 0.4
Medication for cholesterol 1.5 2.3 4.7 2.2 -0.7 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 1.9 -0.8 1.0 -1.4
Back pain experienced in last month 0.7 1.0 1.6 -1.3 1.1 -0.3
Mineral and other dietary supplements 5.1 6.9 10.2 1.0 -3.1 3.2
Breast cancer (self-reported) 0.4 0.4 0.7 0.3 0.8 -0.8
Asthma (self-reported) 0.2 0.5 0.8 -0.7 0.3 0.9
Osteoporosis (self-reported) 0.2 0.3 0.6 -0.5 0.7 -0.1
Osteoarthritis (self-reported) 2.6 3.3 6.2 -0.9 2.5 -1.7
Medication: Aspirin 1.8 2.3 5.0 -2.2 1.1 -0.8
Medication: Gliclazide 0.3 0.4 0.8 -0.9 -0.2 0.5
Illnesses of father: None of the above (group 1) 0.4 0.5 0.8 -0.8 0.9 -0.1
Smoking status: Current 0.9 1.4 3.7 -1.9 -0.3 -0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 2.7 -1.6 1.1 -0.3
Whole body water mass 0.6 3.3 9.6 -0.6 3.1 0.2
Leg predicted mass (right) 0.5 2.7 7.7 -0.5 2.8 0.5
Arm fat mass (left) 0.9 3.8 9.5 -3.1 1.4 0.4
Number of self-reported non-cancer illnesses 1.1 1.9 5.2 -2.3 0.0 0.6
Average weekly champagne plus white wine intake 0.3 0.4 1.0 1.0 0.1 -0.4
Miserableness 0.3 0.5 1.3 -0.3 0.4 -1.1
Guilty feelings 0.1 0.1 0.3 0.4 -0.1 -0.5
Wears glasses or contact lenses 1.1 1.3 1.7 1.3 -1.0 1.1
Ever taken oral contraceptive pill 0.5 0.6 1.3 -1.2 -0.2 -0.6
Hearing aid user 0.4 0.5 1.1 -1.0 0.1 0.5
Mother’s age at death 1.2 1.5 4.2 2.1 0.2 -0.3
Financial situation satisfaction 0.5 0.6 1.2 -0.8 0.1 -1.1
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.5 0.9 -0.5 1.9
Commuting to job workplace: Public transport 2.5 3.0 4.9 0.6 -2.2 1.9
Eye problems/disorders: Glaucoma 0.1 0.1 0.2 0.4 0.0 0.3
Medication: Blood pressure 0.3 0.6 0.9 -0.9 0.4 -0.8
Pain type(s) experienced in last month: Hip pain 2.6 3.3 5.5 -0.4 2.0 -2.4
Supplements: Fish oil (including cod liver oil) 5.3 6.9 11.3 -1.7 3.4 -2.5
High cholesterol (Self-reported) 0.9 1.6 4.1 -2.0 -0.6 0.6
Medication: Bendroflumethiazide 2.1 3.2 5.9 -0.4 -2.4 1.9
Medication: Paracetamol 1.2 1.8 2.8 -1.1 1.7 -1.2
Medication: Lisinopril 0.9 1.2 1.7 1.2 -0.8 1.3
Medication: Atorvastatin 0.6 0.8 1.7 -1.3 -0.2 -0.8
Illnesses of father: High blood pressure 1.0 1.3 1.9 -0.3 -1.4 1.3
Alcohol drinker status: Never 2.3 2.8 6.9 2.6 0.8 -0.8
Ever smoked 3.0 5.3 16.0 -4.0 -0.2 -0.1
Basal metabolic rate 0.6 3.4 8.3 -1.4 2.9 0.4
Leg fat percentage (left) 2.4 8.7 25.9 -5.1 0.2 0.5
Arm fat-free mass (left) 0.8 4.2 11.2 -1.2 3.3 0.1
Number of operations (self-reported) 0.6 1.0 2.1 -1.4 -0.7 0.5
Average weekly beer plus cider intake 1.8 2.6 3.6 -1.7 1.9 -1.2
Irritability 0.4 0.6 1.1 0.0 0.8 -1.1
Risk taking 0.8 1.1 2.1 -0.9 -0.7 1.5
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.6 0.3 0.1 0.8
Fractured/broken bones in last 5 years 0.4 0.5 0.8 -0.9 -0.4 0.8
Age started oral contraceptive pill 2.7 3.4 5.6 2.4 1.4 -1.6
Diastolic blood pressure, automated reading 0.4 1.2 2.8 -1.7 -0.3 0.7
Ever depressed for a whole week 2.7 3.4 3.7 -1.9 1.8 -1.8
Unable to work because of sickness or disability 1.1 1.4 3.6 -1.9 -0.7 0.2
Commuting to job workplace: Cycle 1.9 2.4 2.4 1.5 -1.6 1.5
Myopia 11.7 16.9 25.6 0.0 -5.1 5.0
Vascular/heart problems diagnosed by doctor 0.4 1.0 2.4 1.6 0.0 -0.8
Cholesterol lowering medication 0.8 1.1 1.5 -1.1 0.8 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.0 -0.9 -0.8 1.0
Pain experienced in last month 3.5 5.8 9.6 1.5 -3.1 2.3
Supplements: Calcium 3.8 4.2 7.0 -0.2 2.4 -2.6
Basal cell carcinoma (self-reported) 1.2 1.5 4.0 2.0 -0.3 0.6
Heart attack/myocardial infarction (self-reported) 1.1 1.5 3.1 -0.0 -1.7 1.2
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 7.7 -2.8 -1.1 0.6
Heart disease (siblings) 0.2 0.3 0.5 -0.7 -0.4 0.4
Alcohol drinker status: Previous 0.2 0.2 0.5 0.0 -0.2 -0.7
Pack years of smoking 0.1 0.1 0.2 0.0 -0.3 -0.4
Impedance of whole body 1.0 5.1 12.6 -1.5 -3.5 0.7
Leg fat mass (left) 1.9 7.4 20.9 -4.6 1.1 0.6
Arm predicted mass (left) 0.7 3.5 9.1 -1.1 3.0 0.4