Hub : Genes

RPL23AP82

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0720	0.0330	0.0046	0.001	0.007	-0.001	0.013	-0.001	2.0e-01	4.1e-02	3.9e-01	0.0093	0.38000
2	TCGA	Bladder Urothelial Carcinoma	0.1000	0.0460	0.0035	0.023	0.054	0.049	NA	0.028	4.1e-03	2.4e-05	5.2e-05	NA	0.00170
3	TCGA	Breast Invasive Carcinoma	0.0292	0.0163	0.0067	0.017	0.007	0.007	NA	0.013	1.6e-04	1.1e-02	9.6e-03	NA	0.00098
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.0507	0.0263	0.0012	0.038	0.011	0.023	NA	0.024	4.1e-05	1.6e-02	1.2e-03	NA	0.00099
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1260	0.0750	0.0067	0.022	0.021	0.022	NA	0.032	1.9e-02	2.2e-02	1.9e-02	NA	0.00630

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.6	1.7	0.2	-0.9	0.0	1.3	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	2.0	-0.2	-1.4	0.0	-0.0	0.0
Depressed Affect (Nagel 2018)	0.2	0.5	1.9	-0.2	1.4	0.0	-0.3	0.6
Depression (Nagel 2018)	0.2	0.2	0.6	0.6	-0.2	0.0	0.5	0.8
Intelligence (Savage-Jansen 2018)	1.5	4.6	12.3	-0.2	2.5	0.0	2.1	-3.5
Neuroticism (Nagel 2018)	0.3	0.8	2.9	-0.6	1.7	0.0	0.2	-0.8
Schizophrenia (2018)	0.0	0.0	0.0	-0.2	0.0	0.0	0.0	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0
Worry (Nagel 2018)	0.4	0.9	2.5	-1.6	1.0	0.0	0.2	-1.0
Alzheimer’s Disease (in mother)	2.2	2.5	7.2	-2.7	-1.7	-1.0	-1.1	0.7
Alzheimer’s Disease (in father)	3.0	3.3	6.3	-0.5	1.8	1.8	1.8	-2.5
Alzheimer’s Disease (including proxy)	1.1	1.6	6.6	-2.6	0.1	0.2	0.2	-1.1
Crohns Disease (2017)	0.5	1.0	2.6	1.6	-0.3	0.2	0.2	1.5
Irritable Bowel Disease (IBD)	0.6	1.5	3.6	1.9	-1.0	0.6	0.6	1.6
Ulcerative Colitis (UC)	0.7	1.3	3.0	0.9	-1.4	0.6	0.6	1.7
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	3.3	6.3	10.7	0.2	-2.1	-3.3	-3.2	2.4
Verbal and Numeric Reasoning (VNR)	1.6	3.9	18.2	0.3	0.9	0.4	0.5	-4.3
Breast Cancer	0.1	0.2	0.5	-0.7	0.4	0.2	0.2	-0.6
Ovarian Cancer	0.5	0.7	2.5	1.6	0.9	0.3	0.3	0.0
Prostate Cancer	0.6	0.9	3.6	1.9	-0.0	0.5	0.6	-0.6
Age at First Birth	0.7	1.1	2.6	-1.6	0.7	0.0	1.5	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.5	-0.3	0.0	0.0	0.5
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.2	0.3	0.8	0.9	-0.5	0.0	0.5	0.6
Mean Putamen Volume	1.9	2.2	5.2	2.3	-2.1	0.0	-1.0	0.5
Fasting Glucose	0.2	0.3	1.4	1.2	-0.2	0.0	0.1	0.1
HbA1C	0.5	0.5	1.9	1.4	0.2	0.0	0.1	-0.8
HDL Cholesterol	0.1	0.1	0.4	0.6	0.3	0.0	0.0	0.4
LDL Cholesterol	0.5	0.8	3.6	-0.2	-0.8	0.0	0.0	1.9
Lupus	0.1	0.1	0.1	0.2	-0.4	-0.4	-0.4	-0.1
Neuroticism (2016)	0.6	0.9	1.6	0.9	0.8	-0.8	-0.8	-1.2
Primary Biliary Cirrhosis	0.6	0.9	3.3	1.8	0.1	0.0	-1.1	0.3
Rheumatoid Arthritis	0.4	0.5	2.6	0.3	1.6	0.0	0.0	0.1
Schizophrenia (2014)	0.0	0.1	0.3	0.6	0.0	0.0	0.0	0.0
Triglycerides	1.0	1.6	6.3	-2.5	-0.4	0.0	0.0	1.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.2	0.2	1.1	1.0	0.0	0.0	0.0	0.0
Blood Eosinophil Count	0.4	3.4	5.6	2.1	-1.0	-1.7	-1.8	2.4
Blood Platelet Count	0.2	2.3	7.7	2.8	0.8	-1.3	-1.3	0.3
Blood Red Count	4.6	44.7	204.5	14.3	2.1	2.6	2.5	1.5
Blood White Count	0.7	4.9	17.5	0.6	-1.8	-1.3	-1.4	4.2
Heel T-Score	0.4	3.1	4.7	-0.5	1.5	2.1	2.2	-1.9
BMI	0.6	3.8	5.7	-2.4	-1.7	-2.2	-2.2	0.2
Height	0.1	2.3	8.1	0.4	1.5	0.7	0.7	-2.9
Waist Hip Ratio (WHR)	0.4	1.8	5.8	2.4	0.6	1.1	1.1	-0.5
Systolic Blood Pressure	0.1	0.3	0.6	-0.6	0.8	-0.5	-0.5	-0.1
Smoking Status	0.4	0.9	1.8	1.3	0.5	1.0	1.0	0.6
Allergy or Eczema	1.0	2.7	5.5	1.5	-0.4	2.3	2.3	-0.8
Cardiovascular Disease	1.6	5.4	8.8	-3.0	-1.9	-2.6	-2.6	0.8
Hypothyroidism (self reported)	0.5	1.1	2.0	0.6	-1.4	-0.8	-0.8	1.4
Respiratory disease	0.9	2.0	2.9	1.7	-1.0	-1.7	-1.7	0.9
Type 2 Diabetes (T2D) (2018)	0.6	1.0	1.7	-1.3	-0.7	-1.1	-1.1	0.8
Lung FEV1/FVC ratio	0.2	1.2	3.5	-1.9	-0.5	0.8	0.8	-1.1
Lung FVC	0.5	2.5	4.6	-1.5	0.8	-2.1	-2.1	-0.5
Neuroticism	0.4	1.0	3.9	0.1	2.0	0.7	0.7	-0.4
Chronotype (morning person)	0.6	1.5	2.7	1.2	0.7	1.6	1.7	0.1
Hair Pigment	0.0	0.4	0.9	-0.6	0.3	1.0	0.9	-0.0
Tanning	0.1	1.1	1.7	-0.9	1.3	-1.2	-1.2	-0.3
Hand grip strength (left)	0.3	0.7	2.0	0.0	0.8	0.7	0.7	-1.4
Number of treatments/medications taken	2.4	4.4	6.9	-0.4	-1.2	-2.6	-2.6	2.6
Average weekly spirits intake	0.3	0.4	0.8	0.9	0.8	0.0	0.1	0.5
Sensitivity / hurt feelings	0.3	0.5	0.9	0.9	0.7	0.4	0.3	-0.9
Frequency of depressed mood in last 2 weeks	0.2	0.3	1.3	0.5	-1.1	-0.0	0.0	0.3
Hearing difficulty/problems: Yes	0.8	1.2	3.9	0.7	1.1	-0.5	-0.5	-2.0
Relative age of first facial hair	0.9	1.8	4.2	-2.1	0.3	1.5	1.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.7	1.3	-0.0	0.9	0.9	-0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.8	-0.1	-0.3	-0.8	-0.8	0.9
Ever had hysterectomy (womb removed)	0.6	0.6	1.5	-0.2	0.1	-1.2	-1.2	-0.1
Systolic blood pressure, automated reading	0.1	0.4	0.8	0.5	0.6	-0.9	-0.9	-0.1
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.4	0.1	-1.2	0.2	0.2	1.1
Angina	2.7	3.5	6.1	-1.9	-0.7	-2.5	-2.5	1.2
Medication for hormone replacement therapy	2.3	2.6	5.4	1.0	-0.6	-2.3	-2.3	1.0
Vitamin and mineral supplements	0.5	0.6	1.0	0.8	-0.0	-1.0	-1.0	-0.7
Supplements: Zinc	1.6	1.7	2.9	1.2	-0.9	-1.7	-1.7	-0.8
Medication: Co-codamol	3.5	4.0	5.1	-1.1	-2.3	-2.1	-2.1	2.1
Medication: Metformin	2.1	2.9	7.7	-2.2	-1.3	0.4	0.4	2.8
Diabetes (father)	1.1	1.4	2.0	-0.1	-1.2	-1.4	-1.4	1.3
Diabetes (mother)	0.5	0.6	1.5	0.3	-0.3	-1.2	-1.2	-0.1
Severe depression (siblings)	0.1	0.2	0.3	0.5	0.5	0.3	0.3	-0.2
Pack years adult smoking proportion	0.6	1.0	1.8	0.3	0.6	1.2	1.1	-1.3
Impedance of leg (right)	0.3	1.6	3.7	-0.1	0.6	1.9	1.9	-0.2
Leg fat-free mass (left)	0.2	0.9	1.4	-0.8	-0.5	-1.2	-1.2	-0.9
Trunk fat percentage	0.5	1.8	3.8	-1.1	-0.5	-1.4	-1.4	1.9
Hand grip strength (right)	0.2	0.6	1.7	-0.9	0.7	-0.4	-0.4	-1.3
Townsend deprivation index at recruitment	0.7	0.9	1.8	0.8	0.0	-1.0	-1.0	1.3
Current tobacco smoking	0.5	0.8	3.5	0.6	0.3	-0.0	-0.0	1.9
Average weekly fortified wine intake	0.3	0.4	1.5	0.0	0.4	-0.4	-0.4	-1.2
Maternal smoking around birth	1.0	1.4	3.1	0.9	0.1	1.8	1.8	-0.0
Fed-up feelings	0.1	0.2	0.3	0.3	-0.5	-0.4	-0.4	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.4	0.5	0.4	0.2	0.2	0.7
Relative age voice broke	1.4	2.1	4.8	-1.1	-1.7	0.8	0.9	2.2
Taking other prescription medications	5.3	8.1	16.2	0.9	-2.3	-3.0	-3.0	4.0
Age when periods started (menarche)	0.7	1.6	3.2	1.8	0.1	0.9	0.9	-1.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.1	-0.5	-1.3	-1.4	-1.4	0.7
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	8.5	-0.1	2.9	0.9	0.8	-2.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	3.3	-1.8	-0.9	-0.9	-0.9	0.0
Qualifications: CSEs or equivalent	0.7	0.9	1.8	1.1	1.4	0.7	0.7	-0.8
Serious illness, injury or assault to yourself	1.3	1.6	3.4	-0.5	-0.9	-1.9	-1.8	0.3
High blood pressure	0.9	2.4	5.2	-0.7	-1.2	-2.3	-2.2	0.4
Hayfever, allergic rhinitis or eczema	1.4	3.1	7.6	0.5	-0.2	2.7	2.8	-0.3
Multivitamins +/- minerals	0.6	0.7	1.4	-1.2	0.5	0.6	0.5	1.2
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.8	-0.7	0.3	0.3	-0.3
Supplements: Glucosamine	0.7	0.8	1.6	0.9	1.1	-0.5	-0.6	1.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	1.3	0.9	-0.3	-0.3	-0.4
Medication: Atenolol	1.7	2.1	4.0	-0.8	-1.4	-2.0	-2.0	-0.1
Medication: Levothyroxine sodium	2.3	3.9	6.3	-0.5	-1.7	-2.5	-2.5	1.9
Sitting height	0.2	1.1	4.5	-0.7	0.4	0.2	0.3	-2.1
Chronic bronchitis/emphysema (father)	0.6	0.7	1.0	1.0	0.8	0.8	0.8	-0.8
High blood pressure (mother)	0.8	1.1	3.1	0.4	0.1	1.0	1.1	-1.7
Body mass index (BMI)	0.8	3.3	5.0	-1.8	-0.8	-2.2	-2.2	1.6
Impedance of leg (left)	0.3	1.6	3.9	0.1	0.5	2.0	2.0	-0.2
Leg predicted mass (left)	0.2	0.9	1.5	-0.7	-0.5	-1.2	-1.2	-0.9
Trunk fat mass	0.3	1.2	1.8	-1.0	-0.4	-1.3	-1.3	1.2
Waist circumference	0.3	1.1	1.5	-1.2	-0.7	-1.1	-1.1	0.9
Number of incorrect matches in round	0.3	0.4	1.1	-1.0	-0.2	0.0	-0.0	1.0
Past tobacco smoking	0.3	0.6	1.0	-0.9	0.2	1.0	1.0	-0.0
Alcohol usually taken with meals	0.2	0.4	1.1	1.0	-0.2	0.6	0.6	0.3
Nervous feelings	0.2	0.4	1.0	-0.9	0.0	0.2	0.2	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.7	1.3	0.6	-0.5	-0.5	-0.0
Hearing difficulty/problems with background noise	0.7	1.1	1.6	1.1	1.1	0.8	0.8	-1.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	-0.1	0.2	0.6	0.6	-0.3
Had menopause	1.7	2.2	5.0	-0.3	-0.2	-1.7	-1.7	2.2
Had other major operations	1.4	1.7	5.8	1.2	0.5	-0.7	-0.8	2.4
Forced vital capacity (FVC)	0.6	2.4	9.6	-1.0	1.0	-0.2	-0.2	-3.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	4.3	0.4	2.1	0.2	0.2	-1.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.1	1.4	0.8	1.0	1.0	-1.1
Qualifications: None of the above	2.7	5.8	21.7	-0.5	-1.7	-1.4	-1.5	4.7
Financial difficulties in last 2 years	0.4	0.5	2.2	-0.4	-1.5	0.0	0.0	-0.3
Mouth/teeth dental problems	0.3	0.4	0.9	0.0	-0.3	-0.7	-0.7	-1.0
Heart attack	2.8	3.6	5.1	-2.3	-0.9	-2.2	-2.2	1.5
Allergy	0.5	1.0	1.7	-0.5	-0.6	-1.3	-1.3	-1.1
Pain all over the body in last month	1.9	2.1	5.9	-0.6	-0.2	-1.4	-1.5	2.4
Diabetes (self-reported)	0.2	0.2	1.0	-1.0	0.4	-0.2	-0.2	0.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.1	2.4	0.4	-0.5	1.5	1.6	-0.7
Medication: Ramipril	1.9	2.5	4.5	-1.6	-0.6	-1.5	-1.6	2.1
Medication: Simvastatin	0.6	0.9	2.5	-0.6	0.3	-0.8	-0.9	1.6
Fluid intelligence score	0.5	1.1	4.7	-0.7	0.4	0.2	0.2	-2.2
Illnesses of siblings	1.6	2.3	3.5	-0.7	1.3	1.7	1.7	-1.9
Neuroticism score	0.2	0.5	1.7	-0.2	1.3	0.4	0.4	-0.7
Weight	0.3	1.6	2.6	-1.6	-0.4	-1.6	-1.6	0.2
Impedance of arm (right)	0.1	0.3	0.5	0.1	-0.4	0.7	0.7	0.7
Arm fat percentage (right)	0.8	3.2	4.8	-1.3	-0.9	-2.0	-2.1	2.2
Trunk fat-free mass	0.1	0.8	2.6	-0.6	0.2	-0.7	-0.7	-1.6
Hip circumference	0.8	3.6	8.6	-2.9	-1.4	-1.8	-1.8	0.9
Time employed in main current job	0.5	0.6	1.1	-0.7	0.1	1.0	1.0	-0.7
Alcohol intake versus 10 years previously	0.1	0.2	0.4	0.2	-0.2	-0.6	-0.6	-0.5
Father’s age at death	1.2	1.5	7.2	2.7	-0.4	-0.2	-0.1	-0.6
Worrier / anxious feelings	0.3	0.5	1.3	-1.0	-0.3	0.3	0.3	-1.1
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.1	0.3	-1.4	-1.5	-1.4	0.3
Falls in the last year	0.4	0.5	0.7	-0.6	0.7	-0.8	-0.8	0.6
Hair/balding pattern: Pattern 3	0.1	0.1	0.5	-0.3	-0.1	-0.0	-0.1	0.7
Number of live births	0.2	0.3	0.5	-0.1	-0.5	-0.7	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	9.0	-1.4	0.2	-0.2	-0.1	-3.0
Pulse rate	0.1	0.1	0.3	-0.0	0.3	0.2	0.2	0.5
Happiness	0.8	1.0	4.4	2.1	0.4	0.4	0.4	-0.1
Noisy workplace	0.6	0.8	3.2	0.2	1.8	-0.6	-0.6	0.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	4.5	0.1	-0.2	0.2	0.3	-2.1
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.1	-0.3	-1.1	0.6	0.6	0.0
Mouth/teeth dental problems: Dentures	2.1	3.6	11.2	-0.7	-0.4	-1.7	-1.7	3.4
Asthma	0.3	0.6	1.6	0.8	-0.2	-0.7	-0.7	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	2.2	-1.5	0.2	0.6	0.5	0.7
Medication: Cholesterol lowering	2.0	3.1	4.8	-1.4	-1.4	-2.2	-2.2	1.4
Depression (self-reported)	1.3	1.6	2.5	1.2	1.2	-1.5	-1.6	0.5
Medication: Lansoprazole	2.2	2.5	5.0	-1.1	-2.2	-1.4	-1.4	1.5
Prospective memory result	1.0	1.2	1.9	1.1	0.4	-1.4	-1.4	-0.9
Lung cancer (father)	1.2	1.4	3.7	0.8	-0.2	1.1	1.1	-1.9
Illnesses of mother	0.2	0.2	0.7	0.1	0.5	-0.2	-0.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	5.5	-1.8	-0.5	-0.6	-0.5	-2.3
Pulse wave Arterial Stiffness index	2.4	2.8	8.6	-1.0	-0.0	-1.5	-1.5	2.9
Impedance of arm (left)	0.1	0.5	1.2	0.4	-0.2	1.1	1.1	0.4
Arm fat mass (right)	0.7	2.8	3.8	-1.7	-0.8	-1.9	-2.0	1.7
Trunk predicted mass	0.1	0.8	2.3	-0.6	0.1	-0.7	-0.7	-1.5
Standing height	0.2	1.6	6.6	0.3	0.6	0.7	0.7	-2.6
Length of working week for main job	0.1	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.1
Exposure to tobacco smoke at home	0.4	0.5	0.7	-0.8	-0.8	-0.6	-0.6	0.5
Breastfed as a baby	1.4	1.7	4.4	0.7	2.1	0.2	0.3	-1.9
Tense / ‘highly strung’	0.2	0.3	1.3	0.3	-0.4	0.2	0.2	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	3.3	1.8	-0.2	0.5	0.5	-0.7
Hair/balding pattern: Pattern 4	0.1	0.2	0.7	0.9	0.2	0.3	0.3	-0.5
Birth weight of first child	0.9	1.5	3.0	1.3	1.1	0.9	1.0	-1.7
Peak expiratory flow (PEF)	0.9	2.0	9.0	-0.6	0.7	-0.0	0.0	-3.0
Pulse wave reflection index	0.1	0.1	0.4	0.2	0.6	-0.2	-0.2	0.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	1.3	0.3	-0.9	-1.0	0.7
Loud music exposure frequency	0.8	0.9	2.0	-1.4	1.2	0.8	0.7	-0.0
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.4	-1.3	-1.0	1.1	1.2	-1.5
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.1	1.3	1.1	1.8	1.8	-0.8
Blood clot in the leg (DVT)	1.4	1.8	4.4	0.1	0.4	-1.4	-1.5	2.1
Medication: Paracetamol	0.4	0.7	2.1	-1.4	-1.1	-0.1	-0.1	0.5
Headache pain in last month	1.3	2.2	5.0	-1.4	-2.2	-1.4	-1.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.2	0.2	0.9	0.7	0.7	-1.8
Glaucoma (self-reported)	0.2	0.3	0.7	0.2	0.3	-0.8	-0.8	-0.1
Gout (self-reported)	0.5	0.6	1.2	0.3	0.8	-1.1	-1.1	0.0
Hypothyroidism/myxoedema (self-reported)	1.2	2.2	3.1	-0.7	-1.3	-1.8	-1.8	1.7
Medication: Amlodipine	0.7	1.0	2.2	-1.5	-0.5	-1.1	-1.1	0.3
Medication: Ventolin 100micrograms inhaler	1.4	1.8	5.2	-0.2	-1.0	-1.1	-1.1	2.3
Birth weight	0.8	1.8	7.1	-0.2	0.9	0.7	0.7	-2.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.8	0.2	-0.1	-0.1	-0.5
High blood pressure (siblings)	1.5	2.2	4.1	0.3	-2.0	-1.8	-1.8	0.7
Forced vital capacity (FVC), Best measure	0.4	1.5	5.0	-1.3	-0.0	-0.6	-0.5	-2.2
Body fat percentage	0.5	2.1	4.0	-1.2	-0.4	-1.6	-1.6	2.0
Leg fat percentage (right)	0.5	1.8	2.7	-1.4	-0.4	-1.4	-1.4	1.7
Arm fat-free mass (right)	0.1	0.6	1.1	-0.7	0.3	-0.8	-0.8	-1.0
Exposure to tobacco smoke outside home	0.2	0.2	0.4	0.1	0.4	-0.6	-0.7	-0.0
Comparative body size at age 10	0.1	0.2	0.7	0.7	-0.2	0.1	0.1	0.8
Number of full brothers	0.3	0.4	1.0	0.4	0.4	-0.6	-0.6	-1.0
Worry too long after embarrassment	0.1	0.2	0.3	-0.6	-0.1	-0.5	-0.5	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	1.6	0.1	0.4	1.3	1.2	-0.7
Wheeze or whistling in the chest in last year	0.7	1.3	2.4	0.7	0.8	-1.5	-1.6	0.8
Number of children fathered	0.3	0.4	1.5	-0.6	-1.2	0.2	0.2	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.8	2.1	3.2	-1.1	-0.8	-1.7	-1.7	1.8
Age at first live birth	1.6	2.9	5.2	-0.1	-0.2	2.2	2.3	-2.1
Pulse wave peak to peak time	2.3	2.7	8.6	0.9	-0.1	1.4	1.5	-2.9
Health satisfaction	0.8	1.0	1.9	0.4	1.0	-1.3	-1.4	0.4
Shortness of breath walking on level ground	1.0	1.2	2.3	1.1	0.7	-1.0	-1.1	-1.5
Qualifications: College or University degree	1.1	3.5	7.9	1.3	0.9	1.8	1.9	-2.8
Eye problems/disorders: None of the above	0.9	1.1	2.8	-1.7	-0.9	0.8	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	0.1	0.1	1.1	1.1	1.2
Emphysema/chronic bronchitis	0.5	0.6	1.5	0.6	1.2	-0.1	-0.1	1.1
Medication for pain relief, constipation, heartburn	1.0	1.7	4.1	2.0	1.3	0.6	0.6	-1.4
Neck or shoulder pain in last month	0.3	0.5	1.0	1.0	-1.0	0.2	0.2	-0.6
Medication: Blood pressure	0.2	0.4	1.3	-0.8	0.3	-0.2	-0.2	1.1
Angina (self-reported)	2.9	3.8	6.1	-2.1	-0.9	-2.5	-2.5	1.3
Migraine (self-reported)	0.4	0.5	1.6	-1.1	0.1	0.1	0.1	1.3
Medication: Ibuprofen	0.6	0.7	1.0	-0.9	0.7	1.0	1.0	0.7
Medication: Allopurinol	2.4	3.2	7.7	-0.3	-0.4	-2.8	-2.8	0.8
Medication: Omeprazole	0.3	0.4	1.1	-0.9	-1.0	0.2	0.1	0.3
Medication: Seretide 50 evohaler	0.4	0.5	2.0	0.2	1.4	-0.4	-0.4	-0.3
Mean time to correctly identify matches	2.7	5.1	8.0	1.1	-1.5	-2.8	-2.8	2.6
Heart disease (mother)	0.8	0.9	1.3	1.0	-1.2	-0.9	-0.9	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	2.0	1.2	-1.4	-1.1	-1.1	0.3
Whole body fat mass	0.3	1.2	1.8	-1.1	-0.3	-1.3	-1.3	1.2
Leg fat mass (right)	0.4	1.5	2.3	-1.5	-0.3	-1.4	-1.5	0.8
Arm predicted mass (right)	0.1	0.4	1.2	-0.3	0.2	-0.6	-0.6	-1.1
Pulse rate, automated reading	0.4	1.2	2.5	0.1	0.8	-1.2	-1.2	1.6
Alcohol intake frequency.	0.2	0.5	1.6	-1.3	0.1	0.1	0.1	-0.8
Comparative height size at age 10	0.1	0.8	2.9	0.3	1.7	0.5	0.4	0.6
Number of full sisters	0.3	0.4	0.8	-0.3	0.2	-0.7	-0.7	0.9
Suffer from ‘nerves’	0.2	0.3	0.7	0.2	0.3	-0.5	-0.5	-0.9
Overall health rating	2.6	5.7	8.8	-1.2	-1.0	-2.9	-2.9	3.0
Chest pain or discomfort	3.4	4.9	10.2	-1.8	-0.0	-3.2	-3.2	1.0
Had major operations	0.6	0.7	2.7	1.6	0.6	-0.2	-0.2	-0.4
Age at last live birth	0.5	0.8	2.7	0.7	-0.6	0.4	0.4	-1.7
Family relationship satisfaction	0.1	0.1	0.6	-0.8	0.0	-0.1	-0.0	0.4
Leg pain on walking	0.7	0.9	3.4	0.2	-0.1	0.7	0.7	1.8
Qualifications: NVQ or HND or HNC or equivalent	1.8	2.1	5.4	1.6	1.3	0.8	0.8	-2.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.6	-0.3	-0.2	-0.3	-0.4	1.3
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.0	0.2	0.9	1.0	1.0	-0.4
Medication: Aspirin	0.1	0.1	0.5	-0.7	-0.2	-0.0	-0.1	0.1
Supplements: Vitamin C	1.1	1.2	2.6	0.2	-1.6	1.2	1.2	-0.7
Knee pain experienced in last month	0.8	1.3	3.2	-1.8	1.4	-0.8	-0.8	0.2
Hypertension (Self-reported)	1.0	2.8	5.6	-1.0	-1.2	-2.4	-2.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.6	2.6	-1.5	-1.2	-0.9	-0.9	1.6
Illnesses of father: Heart disease	1.6	2.2	5.7	-2.4	0.2	-1.5	-1.5	0.7
Illnesses of siblings: Diabetes	1.5	1.8	5.1	2.2	-0.5	-0.6	-0.6	1.8
Smoking status: Previous	0.3	0.4	1.8	1.4	0.0	0.0	0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	3.2	-1.3	0.2	0.3	0.3	-1.8
Whole body fat-free mass	0.1	0.8	1.6	-0.8	-0.2	-1.0	-1.0	-1.3
Leg fat-free mass (right)	0.2	0.9	1.4	-0.5	-0.5	-1.2	-1.2	-1.2
Arm fat percentage (left)	0.6	2.5	4.4	-1.2	-0.6	-1.7	-1.8	2.1
Average weekly red wine intake	0.5	0.8	1.1	-0.8	-1.0	-1.0	-1.0	0.4
Handedness (chirality/laterality): Left-handed	1.9	2.3	3.5	1.0	1.2	1.9	1.9	-1.4
Mood swings	0.1	0.3	0.8	-0.9	-0.0	0.3	0.2	0.7
Loneliness, isolation	1.5	2.1	2.8	1.4	1.7	1.5	1.5	-1.2
Long-standing illness, disability or infirmity	1.1	1.7	5.0	0.9	-0.0	-1.1	-1.1	2.2
Ever had bowel cancer screening	1.3	1.5	2.7	0.8	1.0	1.7	1.6	0.6
Diabetes diagnosed by doctor	0.1	0.1	0.1	-0.3	0.4	-0.2	-0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.7	-0.7	0.8	0.4	0.4	-0.5
Friendships satisfaction	0.3	0.4	0.7	-0.3	-0.7	0.6	0.7	-0.9
Qualifications: nursing, teaching	1.1	1.8	5.8	-1.3	-0.5	0.8	0.8	-2.4
Commuting to job workplace: Walk	1.2	1.3	4.5	1.2	-0.6	0.2	0.2	-2.1
Eye problems/disorders: Cataract	1.0	1.1	3.9	0.5	2.0	-0.7	-0.7	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.1	-0.2	-0.3	0.3	0.3	-0.2
Medication for cholesterol	3.4	5.1	12.0	0.5	0.8	3.5	3.4	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	2.7	1.4	0.9	-0.7	-0.7	-1.6
Back pain experienced in last month	2.2	3.2	4.3	-2.0	-1.1	-2.0	-2.1	1.6
Mineral and other dietary supplements	0.9	1.3	3.7	0.0	-1.9	-0.9	-0.8	-1.1
Breast cancer (self-reported)	1.1	1.3	2.5	0.5	-0.4	1.5	1.6	1.0
Asthma (self-reported)	0.3	0.7	1.3	0.9	-0.4	-0.7	-0.7	1.1
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.2	-0.3	-0.7	-0.7	-0.3
Osteoarthritis (self-reported)	1.4	1.8	3.0	-0.1	1.6	-1.7	-1.7	0.6
Medication: Aspirin	0.1	0.2	0.6	-0.8	-0.4	0.0	0.0	0.4
Medication: Gliclazide	0.3	0.3	1.2	1.1	0.5	0.1	0.0	0.4
Illnesses of father: None of the above (group 1)	0.8	0.9	2.0	1.4	-0.1	1.0	1.0	-0.8
Smoking status: Current	0.4	0.7	2.3	0.3	0.5	-0.5	-0.5	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	7.8	-2.8	0.4	0.2	0.2	-0.9
Whole body water mass	0.1	0.7	1.5	-0.7	-0.2	-0.9	-0.9	-1.2
Leg predicted mass (right)	0.2	0.8	1.3	-0.5	-0.5	-1.1	-1.1	-1.2
Arm fat mass (left)	0.5	2.1	3.0	-1.5	-0.4	-1.7	-1.7	1.4
Number of self-reported non-cancer illnesses	3.7	6.4	11.3	0.3	-0.5	-3.3	-3.4	3.1
Average weekly champagne plus white wine intake	2.4	3.3	6.2	1.6	-1.1	2.5	2.5	0.8
Miserableness	0.2	0.3	1.0	0.5	1.0	0.0	0.0	-0.4
Guilty feelings	0.7	1.0	2.3	-0.8	1.5	1.1	1.0	-0.2
Wears glasses or contact lenses	0.3	0.4	0.7	-0.0	0.7	-0.8	-0.8	-0.2
Ever taken oral contraceptive pill	0.9	1.0	2.4	0.1	-0.8	0.9	1.0	-1.6
Hearing aid user	0.1	0.1	0.1	0.2	-0.1	-0.4	-0.4	0.2
Mother’s age at death	0.8	1.0	1.5	0.8	1.1	1.2	1.2	-0.4
Financial situation satisfaction	1.0	1.2	4.8	2.2	0.9	0.5	0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	0.3	0.1	0.8	0.8	-0.6
Commuting to job workplace: Public transport	0.3	0.4	0.7	0.1	-0.5	-0.9	-0.8	-0.6
Eye problems/disorders: Glaucoma	0.3	0.3	1.5	1.2	0.2	0.0	0.0	-0.2
Medication: Blood pressure	0.9	1.7	3.4	-1.3	-0.3	-1.9	-1.8	-0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.0	0.9	0.6	0.5	0.9
Supplements: Fish oil (including cod liver oil)	0.9	1.1	4.4	0.1	0.4	0.8	0.7	2.1
High cholesterol (Self-reported)	1.3	2.4	3.5	-1.2	-1.9	-1.4	-1.4	1.7
Medication: Bendroflumethiazide	1.0	1.5	5.1	-2.3	-0.5	1.1	1.1	-0.1
Medication: Paracetamol	0.3	0.4	0.7	-0.8	-0.6	0.7	0.7	0.3
Medication: Lisinopril	0.4	0.6	1.6	0.5	-0.3	-0.6	-0.6	1.3
Medication: Atorvastatin	2.8	3.5	5.7	-1.4	-2.0	-2.4	-2.4	-0.6
Illnesses of father: High blood pressure	0.2	0.3	1.0	-0.3	-1.0	-0.4	-0.4	0.1
Alcohol drinker status: Never	2.4	2.9	8.8	-3.0	-1.0	-1.5	-1.5	-0.0
Ever smoked	0.5	0.9	1.5	1.0	-0.2	-1.2	-1.2	0.7
Basal metabolic rate	0.2	0.9	1.2	-0.9	-0.2	-1.1	-1.1	-1.1
Leg fat percentage (left)	0.5	1.9	3.1	-1.3	-0.6	-1.5	-1.5	1.8
Arm fat-free mass (left)	0.1	0.8	1.4	-1.2	-0.3	-0.9	-0.9	-0.7
Number of operations (self-reported)	0.7	1.1	1.8	0.3	0.0	-1.3	-1.3	1.3
Average weekly beer plus cider intake	0.7	1.0	2.0	-0.2	0.2	-1.4	-1.4	-0.8
Irritability	2.0	3.4	9.5	-0.1	3.1	1.4	1.4	-2.0
Risk taking	0.8	1.1	2.0	1.4	1.2	0.8	0.9	-0.8
Ever had prostate specific antigen (PSA) test	1.6	1.8	5.0	2.2	0.7	1.4	1.3	0.1
Fractured/broken bones in last 5 years	1.6	2.0	4.4	1.2	-0.3	-2.1	-2.1	0.2
Age started oral contraceptive pill	0.4	0.5	1.7	0.8	-1.3	0.4	0.4	-0.1
Diastolic blood pressure, automated reading	0.3	1.0	1.7	-0.9	-0.4	-1.3	-1.3	1.0
Ever depressed for a whole week	0.7	0.8	2.2	1.5	1.0	0.6	0.6	-0.6
Unable to work because of sickness or disability	1.4	1.8	6.6	-0.5	-1.0	-0.7	-0.8	2.6
Commuting to job workplace: Cycle	0.7	0.8	1.8	0.5	-0.4	1.3	1.4	-0.4
Myopia	1.6	2.4	4.0	-1.5	-1.4	-1.4	-1.4	2.0
Vascular/heart problems diagnosed by doctor	1.1	3.0	6.2	1.0	1.2	2.5	2.5	-0.7
Cholesterol lowering medication	0.3	0.4	0.8	-0.7	-0.5	-0.9	-0.9	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.3	-1.5	-1.1	-0.1	-0.1	-0.6
Pain experienced in last month	0.3	0.5	1.1	1.0	0.5	0.5	0.6	-0.8
Supplements: Calcium	0.2	0.2	0.4	0.6	-0.0	0.5	0.5	-0.2
Basal cell carcinoma (self-reported)	0.7	0.8	2.8	0.6	-0.9	-0.3	-0.2	1.7
Heart attack/myocardial infarction (self-reported)	3.7	4.8	6.3	-2.3	-1.4	-2.5	-2.5	2.0
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	5.3	-0.0	0.3	-1.4	-1.5	2.3
Heart disease (siblings)	0.3	0.3	0.8	-0.3	0.1	-0.9	-0.9	-0.2
Alcohol drinker status: Previous	0.7	0.8	1.4	-1.1	0.4	1.2	1.2	-0.2
Pack years of smoking	0.5	0.7	1.8	0.3	0.6	0.8	0.7	-1.3
Impedance of whole body	0.2	1.1	2.7	0.1	0.3	1.6	1.6	0.2
Leg fat mass (left)	0.4	1.5	2.3	-1.3	-0.4	-1.5	-1.5	1.0
Arm predicted mass (left)	0.1	0.7	1.3	-1.2	-0.2	-0.8	-0.8	-0.8